Kinase Subfamily ROCK
From WikiKinome
Kinase Classification: Group AGC: Family DPMK: Subfamily ROCK
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Evolution
ROCK is an animal specific kinase duplicated in vertebrates (ROCK1, ROCK2), and with homologs in Drosophila (rok) and C. elegans (let-502).
Domain Structure
ROCK kinases are long multidomain proteins of ~1300 AA. They have an N-terminal kinase domain with the AGC-specific kinase domain tail, followed by a central coiled-coil region, HR1 domain, Rho-binding, HR and PH domains. The PH domain is split by an inserted CRD (cysteine-rich Zn finger motif).