Kinase Subfamily ROCK

Kinase Classification: Group AGC: Family DPMK: Subfamily ROCK

This page has not been edited yet.

Evolution

ROCK is an animal specific kinase duplicated in vertebrates (ROCK1, ROCK2), and with homologs in Drosophila (rok) and C. elegans (let-502).

Domain Structure

ROCK kinases are long multidomain proteins of ~1300 AA. They have an N-terminal kinase domain with the AGC-specific kinase domain tail, followed by a central coiled-coil region, HR1 domain, Rho-binding, HR and PH domains. The PH domain is split by an inserted CRD (cysteine-rich Zn finger motif).