Kinase Subfamily TAK1
From WikiKinome
Kinase Classification: Group TKL: Family MLK: Subfamily TAK1
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Evolution
TAK1 is found in all studied holozoa. It has a single copy in human (TAK1/MAP3K7), with two members in nematodes, three in Drosophila and expanded to 8 in sponge.
Domain Structure
TAK1 proteins have an N-terminal kinase domain and an unannotated conserved region in the C-terminus.
Functions
TAK1 (TGF beta Activated Kinase 1) transduces signals from TGF beta receptors to NFkB, and can also act as a MAP3K to activate JNK MAPK signaling. TAK1 forms complexes with TRAF6 and the pseudophosphatase TAB1. In Drosophilids, where TAB1 is lost, there are some scattered changes in conserved TAK1 residues.
References
- Lawler S, Feng XH, Chen RH, Maruoka EM, Turck CW, Griswold-Prenner I, and Derynck R. The type II transforming growth factor-beta receptor autophosphorylates not only on serine and threonine but also on tyrosine residues. J Biol Chem. 1997 Jun 6;272(23):14850-9. DOI:10.1074/jbc.272.23.14850 |
- Huse M, Chen YG, Massagué J, and Kuriyan J. Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12. Cell. 1999 Feb 5;96(3):425-36. DOI:10.1016/s0092-8674(00)80555-3 |
- Lee MK, Pardoux C, Hall MC, Lee PS, Warburton D, Qing J, Smith SM, and Derynck R. TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA. EMBO J. 2007 Sep 5;26(17):3957-67. DOI:10.1038/sj.emboj.7601818 |
- Manning G, Young SL, Miller WT, and Zhai Y. The protist, Monosiga brevicollis, has a tyrosine kinase signaling network more elaborate and diverse than found in any known metazoan. Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9674-9. DOI:10.1073/pnas.0801314105 |
