Kinase Subfamily eEF2K

Kinase Classification: Group PKL: Family Alpha: Subfamily eEF2K

Domain Structure

eEF2K has an alpha kinase domain flanked by an N-terminal calmodulin-binding domain and a C-terminal eEF2 binding domain.

Evolution

eEF2K is found in most unikonts, though lost in fungi and insects.

Functions

eE2FK phosphorylates eukaryotic elongation factor 2 and inhibits protein synthesis. It appears to integrate multiple signals. It contains a large number of phosphorylation sites that include targets of AMPK, p38 and RSK family kinases, and is also regulated by Calcium.