Protein (view, download) , Domain (view, download)
BRDT_Mmus        MSLPSRQT----------------------------------------------------
BRD4_Mmus        MSTESGP-----------------------------------------------------
BRD3_Mmus        MSTTAA------------------------------------------------------
BRD2_Mmus        MLQNVTPHK-LP-GE-GNA--G-LLGLG--------------------------------
BRD2_Hsap        MLQNVTPHNKLP-GE-GNA--G-LLGLG--------------------------------
BRD3_Hsap        MSTATTV-----------------------------------------------------
BRD4_Hsap        MSAESGP-----------------------------------------------------
BRDT_Hsap        MSLPSRQT----------------------------------------------------
Y119C1B.8_Cele   MSEGSGDQSQQR-PW---------------------------------------------
DDB0220693_Ddis  MSLEQQDETVV-EEETKTSFETNNSTANNTNNNTDNTYKEEILKSTESIT--------RN
DDB0220694_Ddis  MSNKTLPYCCE-HGL-KDEVIA-LLAKGEDVNQ-------------KDGS----------
BRD_Spur         ------------------------------------------------------------
F13C5.2_Cele     MPTTRSA-----------------------------------------------------
F57C7.1b_Cele    MSDYSAKPSGSLARI-G--DYD-LSSDDSDQND-------------EDETLIASKTIQTG
AqueK041_Aque    MMEQNVSPPRLE-SRSS-SATP-MLNPGLVATQ---------------------------


BRDT_Mmus        ------------------------------------------------------------
BRD4_Mmus        ------------------------------------------------------------
BRD3_Mmus        ------------AP----------------------------------------------
BRD2_Mmus        --------PEAAAP----------------------------------------------
BRD2_Hsap        --------PEAAAP----------------------------------------------
BRD3_Hsap        ------------AP----------------------------------------------
BRD4_Hsap        ------------------------------------------------------------
BRDT_Hsap        ------------------------------------------------------------
Y119C1B.8_Cele   -----------ASPR------------------------------------Q--------
DDB0220693_Ddis  --------DDKVDPTSATALE---------------------------------------
DDB0220694_Ddis  ----------NRYPLHYAAIG---GYIEIVAML----------------LER--------
BRD_Spur         ------------------------------------------------------------
F13C5.2_Cele     ------------------------------------------------------------
F57C7.1b_Cele    AVQVNDIAVAEASPAETD--------------A----------------KSS--------
AqueK041_Aque    -----------ATPTTVPAMLVQSGN------VQNVSFQQQGGGGINSVPTNLTSYTSII


BRDT_Mmus        ------------------------------------------------------------
BRD4_Mmus        ------------------------------------------------------------
BRD3_Mmus        ------------------------------------------------------------
BRD2_Mmus        ------------------------------------------------------------
BRD2_Hsap        ------------------------------------------------------------
BRD3_Hsap        ------------------------------------------------------------
BRD4_Hsap        ------------------------------------------------------------
BRDT_Hsap        ------------------------------------------------------------
Y119C1B.8_Cele   ---------------QP-----IKGIVQP-------------------------------
DDB0220693_Ddis  ---------------KD----I-INNGEYSGS------------------------SSSS
DDB0220694_Ddis  ---------------GA----L-VNCSTPRGA------------------------TPLH
BRD_Spur         ------------------------------------------------------------
F13C5.2_Cele     -----------------------NHPAPK-------------------------------
F57C7.1b_Cele    ---------------AS----PVSGPEPPTSAVVENRDLDEFKKESGSNDDKQEEINEDK
AqueK041_Aque    DPSQLLVKTEGVTSASPLSVGGANRTTPPTL-V----------------------TG---


BRDT_Mmus        ------------------------------------------------------------
BRD4_Mmus        -----------------------------------GTRLRNL------------------
BRD3_Mmus        ------------------------------------------------------------
BRD2_Mmus        -----------------------------------GKRIRKP------------------
BRD2_Hsap        -----------------------------------GKRIRKP------------------
BRD3_Hsap        ------------------------------------------------------------
BRD4_Hsap        -----------------------------------GTRLRNL------------------
BRDT_Hsap        ------------------------------------------------------------
Y119C1B.8_Cele   ------------------------------------------------------------
DDB0220693_Ddis  GN-------------------------------NNINGSNNIKNIV--------------
DDB0220694_Ddis  YA-------------------------------SRGGRIECIQLLIDNKADVNCRD-GAG
BRD_Spur         ------------------------------------------------------------
F13C5.2_Cele     ------------------------------------------------------------
F57C7.1b_Cele    DS-------------------------------NEETVFQQTESGSADVVDKTDVKQKDS
AqueK041_Aque    -TGSITATPTAYTTAVTTSATSTTTVGGVTGGSILGKRIRRT------------------


BRDT_Mmus        ------------------------------------------------------------
BRD4_Mmus        -------------------------------------------------------PVMGD
BRD3_Mmus        ------------------------------------------------------------
BRD2_Mmus        -------------------------------------------------------SLLYE
BRD2_Hsap        -------------------------------------------------------SLLYE
BRD3_Hsap        ------------------------------------------------------------
BRD4_Hsap        -------------------------------------------------------PVMGD
BRDT_Hsap        ------------------------------------------------------------
Y119C1B.8_Cele   ------------------------------------------------------------
DDB0220693_Ddis  ---------IEKVEQ---------------------------------------------
DDB0220694_Ddis  STPLHTALQCNETKCAIALIET---FGADV--NLKTAEGSTALHLASARGLVPVI-----
BRD_Spur         ------------------------------------------------------------
F13C5.2_Cele     ------------------------------------------------------------
F57C7.1b_Cele    DSSADDDH-------------SHSKSGSVHSPQKPQGSTTPCSVQSPASPVGDEQAVKME
AqueK041_Aque    -------------------------------------------------------STKYD


BRDT_Mmus        ------------------------------------------------------------
BRD4_Mmus        GLETSQMSTTQAQA--------------------------------------------QP
BRD3_Mmus        ----------------------------------------------------------TG
BRD2_Mmus        GFESPTM---------------------------------------------------AS
BRD2_Hsap        GFESPTM---------------------------------------------------AS
BRD3_Hsap        ----------------------------------------------------------AG
BRD4_Hsap        GLETSQMSTTQAQA--------------------------------------------QP
BRDT_Hsap        ------------------------------------------------------------
Y119C1B.8_Cele   ------------------------------------------------------------
DDB0220693_Ddis  -----------------------------------------------LERV----VVNNN
DDB0220694_Ddis  --------------------------------------------VALLENG----ARADV
BRD_Spur         ------------------------------------------------------------
F13C5.2_Cele     ------------------------------------------------------------
F57C7.1b_Cele    EVEEPIVASEEVPDKKPESVKESTDSESSGSEHGFEKMDTAEKVEDECNDDEVAASNGTE
AqueK041_Aque    DFEQPLMRPSKVEA----------------------------------------------


BRDT_Mmus        -----A-IVN------PP--------------PPEYI---N-TKKSGRLTN---------
BRD4_Mmus        QPAN-AASTN------PP--------------PPETS---N-PNKPKRQTN---------
BRD3_Mmus        IPAV-PGPVN------PP--------------PPEVS---N-PSKPGRKTN---------
BRD2_Mmus        VPALQLAPAN------PP--------------PPEVS---N-PKKPGRVTN---------
BRD2_Hsap        VPALQLTPAN------PP--------------PPEVS---N-PKKPGRVTN---------
BRD3_Hsap        IPAT-PGPVN------PP--------------PPEVS---N-PSKPGRKTN---------
BRD4_Hsap        QPAN-AASTN------PP--------------PPETS---N-PNKPKRQTN---------
BRDT_Hsap        -----AIIVN------PP--------------PPEYI---N-TKKNGRLTN---------
Y119C1B.8_Cele   ----------------------------------RVL---PPFGKPTRHTN---------
DDB0220693_Ddis  NGDENNKDIHDSSNNTE---------------DIDI---------------------SKS
DDB0220694_Ddis  RDSKENSPFQS-----L---------------PINLT---ENE-KKEKIENSISQDISKL
BRD_Spur         ------------------------------------------------------------
F13C5.2_Cele     ----------------------------------RAI---SP-DSDDGE-----------
F57C7.1b_Cele    EPEPGDKAADT-----VNPWETPRQEPVDGVVQPRTE---PPAGKPTRHTN---------
AqueK041_Aque    KE---SSETRE-----KT--------------PSEKTTEEEGKGGGNRSTN---------


BRDT_Mmus        -------------------------------------------------QLQFLQRVVLK
BRD4_Mmus        -------------------------------------------------QLQYLLRVVLK
BRD3_Mmus        -------------------------------------------------QLQYMQNVVVK
BRD2_Mmus        -------------------------------------------------QLQYLHKVVMK
BRD2_Hsap        -------------------------------------------------QLQYLHKVVMK
BRD3_Hsap        -------------------------------------------------QLQYMQNVVVK
BRD4_Hsap        -------------------------------------------------QLQYLLRVVLK
BRDT_Hsap        -------------------------------------------------QLQYLQKVVLK
Y119C1B.8_Cele   -------------------------------------------------KLDYIMTTVLK
DDB0220693_Ddis  H-IIKYDKDEMSTIST-IHYSD-DESSKEKQ---------DNINSNNNNNKNKNE-----
DDB0220694_Ddis  FNINKN-REFSGVGKKEDDDNNMKIDKQESEQQSTSDKLYSDITFLIENQKVYAHKCILQ
BRD_Spur         ------------------------------------------------------------
F13C5.2_Cele     ------------------------------------------------------------
F57C7.1b_Cele    -------------------------------------------------CLDFVLFTVVK
AqueK041_Aque    -------------------------------------------------QLQYLKN-VHR


BRDT_Mmus        ALWKHGFSWPFQQPVDAVKLKLPDYYTIIKTPMD--------------------------
BRD4_Mmus        TLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMD--------------------------
BRD3_Mmus        TLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMD--------------------------
BRD2_Mmus        ALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMD--------------------------
BRD2_Hsap        ALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMD--------------------------
BRD3_Hsap        TLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMD--------------------------
BRD4_Hsap        TLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMD--------------------------
BRDT_Hsap        DLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMD--------------------------
Y119C1B.8_Cele   EAGKHKHVWPFQKPVDAVALCIPLYHERVARPMD--------------------------
DDB0220693_Ddis  --------------------QIINSENILDTPMTEASDQTTPSDTPPTLTNNTSSTTTTT
DDB0220694_Ddis  A-------------------RCPNFMSSINNKIE--------------------------
BRD_Spur         ------------HPVDPTKLALPDYFKIIKTPMD--------------------------
F13C5.2_Cele     ----------------------EDDFKSKRT-----------------------------
F57C7.1b_Cele    DALKHKHSWPFQLPVDAIKLEIPEYHNIVNTPMD--------------------------
AqueK041_Aque    IIWRHHYAWPFHKPVDPVALNIPDYFNIIKRPMD--------------------------


BRDT_Mmus        ----------LNTIKKRLENKYY----------EKASECIEDFNTMF-------------
BRD4_Mmus        ----------MGTIKKRLENNYY----------WNAQECIQDFNTMF-------------
BRD3_Mmus        ----------MGTIKKRLENNYY----------WSASECMQDFNTMF-------------
BRD2_Mmus        ----------MGTIKRRLENNYY----------WAASECMQDFNTMF-------------
BRD2_Hsap        ----------MGTIKRRLENNYY----------WAASECMQDFNTMF-------------
BRD3_Hsap        ----------MGTIKKRLENNYY----------WSASECMQDFNTMF-------------
BRD4_Hsap        ----------MGTIKKRLENNYY----------WNAQECIQDFNTMF-------------
BRDT_Hsap        ----------LNTIKKRLENKYY----------AKASECIEDFNTMF-------------
Y119C1B.8_Cele   ----------LKTIENRLKSTYY----------TCAQECIDDIETVF-------------
DDB0220693_Ddis  TTNNTTTAATTTTNSRRKRNSLS----------TPSSEMDPVLDSTS-------------
DDB0220694_Ddis  ----------QQQSQKPIEIKDYSFKLFLSFIEWIYTGSIEKFESTSKSIDLSFQFSILL
BRD_Spur         ----------LGTIKKRLESIYY----------HSAKECISDFNLMF-------------
F13C5.2_Cele     ------------------------------------------------------------
F57C7.1b_Cele    ----------LRTIEKRLRNLYY----------WCAEDAIKDLNTLF-------------
AqueK041_Aque    ----------LTLIKKQLDHNGY----------SSAKECIQDFKTMF-------------


BRDT_Mmus        ----------------------------------------SNCYL--------YNKTGDD
BRD4_Mmus        ----------------------------------------TNCYI--------YNKPGDD
BRD3_Mmus        ----------------------------------------TNCYI--------YNKPTDD
BRD2_Mmus        ----------------------------------------TNCYI--------YNKPTDD
BRD2_Hsap        ----------------------------------------TNCYI--------YNKPTDD
BRD3_Hsap        ----------------------------------------TNCYI--------YNKPTDD
BRD4_Hsap        ----------------------------------------TNCYI--------YNKPGDD
BRDT_Hsap        ----------------------------------------SNCYL--------YNKPGDD
Y119C1B.8_Cele   ----------------------------------------QNCYT--------FNGKEDD
DDB0220693_Ddis  ----------------------------------------ENNTTRKTRGSRNSKKEPEE
DDB0220694_Ddis  MGEKFDCKGLVSYCREFIKESIGDSNVGSIWSIIKKLPTSTRSNL--------GNLVRDC
BRD_Spur         ----------------------------------------TNCYV--------YNKPGED
F13C5.2_Cele     ------------------------------------------------------------
F57C7.1b_Cele    ----------------------------------------DNCKK--------FNDRNDD
AqueK041_Aque    ----------------------------------------NNCYT--------YNKPTDD


BRDT_Mmus        IVVMAQALEK--------LFMQKLSQMPQEEQ-VVGG----------------K-ERIKK
BRD4_Mmus        IVLMAEALEK--------LFLQKINELPTEET-EIMIVQA-------------K-GRGRG
BRD3_Mmus        IVLMAQALEK--------IFLQKVAQMPQEEV-ELLPPAP-------------K-GKGRK
BRD2_Mmus        IVLMAQTLEK--------IFLQKVASMPQEEQ-ELVVTIP-------------K-NSHKK
BRD2_Hsap        IVLMAQTLEK--------IFLQKVASMPQEEQ-ELVVTIP-------------K-NSHKK
BRD3_Hsap        IVLMAQALEK--------IFLQKVAQMPQEEV-ELLPPAP-------------K-GKGRK
BRD4_Hsap        IVLMAEALEK--------LFLQKINELPTEET-EIMIVQA-------------K-GRGRG
BRDT_Hsap        IVLMAQALEK--------LFMQKLSQMPQEEQ-VVGV----------------K-ERIKK
Y119C1B.8_Cele   VTIMAQNVHE--------VIKKSLEQAPREEH-DMDVYWG-------------K-NKKK-
DDB0220693_Ddis  LLLTPEQAKELSNKSKKWIYVPIIEAEAKKEE-VLPAKRDRKQVFNENIFSSSRKSTTKG
DDB0220694_Ddis  LITMVRSWNIF--------TMTKTFSTDINKSDIIEIIKSLAPFI----TETPI-SEIKQ
BRD_Spur         VVLMAQALEK--------LFLTKVAQMPQEEI-ELAPPVK--PGMGDDI-SGPG-RKGRK
F13C5.2_Cele     ----------------------------------------------------PS-GRGRG
F57C7.1b_Cele    IYIMCENIEG--------VVQRGLEWMPSEEK-PADLADHHRRGMFSA--STPS-GKTKG
AqueK041_Aque    VVFMCQALER--------LFDQKVTGMPAEEF-EIVPGQ-----------------KGRK
                                                                           :

BRDT_Mmus        ----DIQ-QKI-----AVSSAKEQIP-SK-A-AEN-VFKRQ------EIPSGL-------
BRD4_Mmus        ----R-K-ETGAAKPG-VSTVPNTTQ-AS-T-SPQTQTPQQ------NPPPPVQATT---
BRD3_Mmus        ----P---AAGAQNAG----SQQVAA-VS-S-VSP-ATPFQ------NIPPTVSQTPVIA
BRD2_Mmus        ----G---AKLAALQGSITSAHQVPA-VS-S-VSH--TALY------TPPPEIPTTV--L
BRD2_Hsap        ----G---AKLAALQGSVTSAHQVPA-VS-S-VSH--TALY------TPPPEIPTTV--L
BRD3_Hsap        ----P---AAGAQSAG----TQQVAA-VS-S-VSP-ATPFQ------SVPPTVSQTPVIA
BRD4_Hsap        ----R-K-ETGTAKPG-VSTVPNTTQ-AS-T-PPQTQTPQP------NP-PPVQATP---
BRDT_Hsap        ----GTQ-QNI-----AVSSAKEKSS-PS-A-TEK-VFKQQ------EIPSVF-------
Y119C1B.8_Cele   ----PAK-SDGGSKS---SSSKK----ND-A-RGPSEAPSEAGSEVS-------------
DDB0220693_Ddis  GEKKNDTASTTNTPI---ITAQQNTTPLSPTQTTTTTTTPTTTTAQQ-------------
DDB0220694_Ddis  TRTANANASNSNQSK---TPAKR----TSTT-NTNNNIPQQNITSSN-------------
BRD_Spur         GRVPGRG-ISANSRLG-IQNASP----QP-S------VPNAATTQ-LPGPPAKNAYVAPL
F13C5.2_Cele     GRGRGRG-RGRGGAT---AA-------GATV-EGGES--------TR-------------
F57C7.1b_Cele    PKQRGRK-STRGRKK---TSLPR----GAST-FKDESVDDNNDDESS-------------
AqueK041_Aque    ---PGPK-SNAGRRT---KMAAA----ES-T------VNLDSPGD---------------


BRDT_Mmus        ----PDI----S-----------------------------------LSPLN--------
BRD4_Mmus        -HPFPAVTPDLIAQPPVMTMVPPQPLQTPS----------PV-PPQPPPPPA--------
BRD3_Mmus        ATPVPTITANVT--------------S--V----------PV-PPPAAPPP---------
BRD2_Mmus        NIPHPSVISSPL--------------L--K----------S--LHSAGPPL---------
BRD2_Hsap        NIPHPSVISSPL--------------L--K----------S--LHSAGPPL---------
BRD3_Hsap        ATPVPTITANVT--------------S--V----------PV-PPAAAPPP---------
BRD4_Hsap        -HPFPAVTPDLIVQTPVMTVVPPQPLQTPP----------PV-PPQPQPPPA--------
BRDT_Hsap        ----PKT----S-----------------------------------ISPLN--------
Y119C1B.8_Cele   SVTT---------------------------------------ASA-AAPTVSE------
DDB0220693_Ddis  NTPAQTESKPP----TTISINIKGS-KSPKTTGGKQQKPTPPSPVVISQPVVPSTPVVAT
DDB0220694_Ddis  NTPQ---------------------------------------QNT------SSSSSSST
BRD_Spur         AMKSPTATQPS----TELPVLPPGAASTQA----------TA-AAMSTSPLVSS------
F13C5.2_Cele     GG--------------------------------------------------------GT
F57C7.1b_Cele    KVDS---------------------------------------IN-F-----DDDDDTAT
AqueK041_Aque    -------------------------VSLVS----------ST-SSTVQPPLV--------


BRDT_Mmus        -----------------------------------M--A---------------------
BRD4_Mmus        --------------------PVP-----------QP--V---------------------
BRD3_Mmus        -----------------------------------P--A---------------------
BRD2_Mmus        -----------------------------------L--A---------------------
BRD2_Hsap        -----------------------------------L--A---------------------
BRD3_Hsap        -----------------------------------P--A---------------------
BRD4_Hsap        --------------------PAP-----------QP--V---------------------
BRDT_Hsap        -----------------------------------V--V---------------------
Y119C1B.8_Cele   ----------------------SASVA---------------------------------
DDB0220693_Ddis  TKKTNSRSKRSTANNNSETTQTPEVVISAPTTTTAAITTPINITPSSDSATIQQLQQSIS
DDB0220694_Ddis  TS----------------------------------------------------------
BRD_Spur         --------------------PPPISTP------VEP--VKQNS-----------------
F13C5.2_Cele     -----GRGGR--------------------------------------------------
F57C7.1b_Cele    EKDAESRAES----------VQPEVVN---------------------------------
AqueK041_Aque    --------------------PAPLSTT---------------------------------


BRDT_Mmus        -------------------------------------------------------QEAPP
BRD4_Mmus        -------------------------------------------------------QSHPP
BRD3_Mmus        -------------------------------------------------------TPIVP
BRD2_Mmus        ----------------------------------------------------------VS
BRD2_Hsap        ----------------------------------------------------------VT
BRD3_Hsap        -------------------------------------------------------TPIVP
BRD4_Hsap        -------------------------------------------------------QSHPP
BRDT_Hsap        -------------------------------------------------------QGASV
Y119C1B.8_Cele   ------------------------------------------------------------
DDB0220693_Ddis  MLEDKIRLISSNNKVATEILNNTITTTTTTAATSAIKDEEIIENTELQTTFTKSSTLAPP
DDB0220694_Ddis  ------------------------------------------------------------
BRD_Spur         -------------------------------------------------------LPGPP
F13C5.2_Cele     ------------------------------------------------------------
F57C7.1b_Cele    ------------------------------------------------------------
AqueK041_Aque    ------------------------------------------------------------


BRDT_Mmus        ------------------------------I-CDSQSLVQITK--GVKRRADTTTPTTSI
BRD4_Mmus        ------------------------------IIATTPQPVKTKK--GVKRKADTTTPTTID
BRD3_Mmus        ------------------------------VV-PPTPPVVKKK--GVKRKADTTTPTTSA
BRD2_Mmus        ------------------------------AA-PPAQPLAKKK--GVKRKADTTTPTPTA
BRD2_Hsap        ------------------------------AA-PPAQPLAKKK--GVKRKADTTTPTPTA
BRD3_Hsap        ------------------------------VV-PPTPPVVKKK--GVKRKADTTTPTTSA
BRD4_Hsap        ------------------------------IIAATPQPVKTKK--GVKRKADTTTPTTID
BRDT_Hsap        ------------------------------N-SSSQTAAQVTK--GVKRKADTTTPATSA
Y119C1B.8_Cele   --------------------------------AKPERKVAGKK--TGKRKAESEDDEK--
DDB0220693_Ddis  SSERKYSNLYSDDEDDTEMVDVSVSIPIPIPIPTPTQTTTKKTTLSKKRKSNTSTIIPTT
DDB0220694_Ddis  ---------------------------------------------STPSKSSSSTPSKST
BRD_Spur         ------------------------------KVRS-PAKTKGAR--GVKRKADTTTPTTVI
F13C5.2_Cele     ---------------------------------------------GRPRGSKN-------
F57C7.1b_Cele    --------------------------------EEPKPSTSQPP--SKKRKAENGEPAVAV
AqueK041_Aque    -----------------------------------TQPVIKRK--GVKRQADTTTPHSGQ
                                                                   :..

BRDT_Mmus        AKA-SS------ESPPT---L-----RETKPVNM-PVKENT------VKNVLPDSQ----
BRD4_Mmus        PIHE---------PPSL---A-----PEPKTAKLGPRR-ESSRPVKPPKKDVPDSQ----
BRD3_Mmus        ITASRS------ESPPP---L-----SEPKQAKVVARRESGGRPIKPPKKDLEDGE----
BRD2_Mmus        ILAPGS--P---ASPPG---S-----LEPKAARLPPMRRESGRPIKPPRKDLPDSQ----
BRD2_Hsap        ILAPGS--P---ASPPG---S-----LEPKAARLPPMRRESGRPIKPPRKDLPDSQ----
BRD3_Hsap        ITASRS------ESPPP---L-----SDPKQAKVVARRESGGRPIKPPKKDLEDGE----
BRD4_Hsap        PIHE---------PPSL---P-----PEPKTTKLGQRR-ESSRPVKPPKKDVPDSQ----
BRDT_Hsap        VKA-SS------EFSPT---F-----TE-KSVALPPIKENM------PKNVLPDSQ----
Y119C1B.8_Cele   --------------PEPLR---A------KRE-----V-------AVVKKEV--------
DDB0220693_Ddis  TIQQEQGQEQGQQQPPQQQ---Q-P----PQQ-----Q-------QPPQQQQPPQQQPPQ
DDB0220694_Ddis  STSSSS------SSSSS-------------------------------------SSSS--
BRD_Spur         EP-PE---P-I-VAPSADYHL-----AQAKPAKIPGRRESSRRNIKPPNRELPESD----
F13C5.2_Cele     SD-GG------------AG---G-P----PA------K--------RGRKKKAKSE----
F57C7.1b_Cele    KI-ATP------ATP--VA---A-H----PQ------E-------ETPRRKNPNTLIE--
AqueK041_Aque    PS-PTSGVP-L-DQPPPPAVVVASTPVHILSSAVPTRRES-TRTIKRPKLDLPGES----


BRDT_Mmus        ------------------------------------------------------------
BRD4_Mmus        ------------------------------------------------------------
BRD3_Mmus        ------------------------------------------------------------
BRD2_Mmus        ------------------------------------------------------------
BRD2_Hsap        ------------------------------------------------------------
BRD3_Hsap        ------------------------------------------------------------
BRD4_Hsap        ------------------------------------------------------------
BRDT_Hsap        ------------------------------------------------------------
Y119C1B.8_Cele   ------------------------------------------------------------
DDB0220693_Ddis  QSTSPSKTQQENTSSTTTTTTTTTTTTNTEDTTTVIDKKPKKKPRHSAPLIPQIKPRLPL
DDB0220694_Ddis  ------------------------------------------------------------
BRD_Spur         ------------------------------------------------------------
F13C5.2_Cele     ------------------------------------------------------------
F57C7.1b_Cele    --------W---------------------------------------------------
AqueK041_Aque    ------------------------------------------------------------


BRDT_Mmus        ------QQHK--------VLKTVKVTEQLKHCSEILKEMLAKKHLPYAWPFYNPVDADAL
BRD4_Mmus        ------QHPG--------PEKSSKISEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEAL
BRD3_Mmus        ------VPQH--------AGKKGKLSEHLRHCDSILREMLSKKHAAYAWPFYKPVDAEAL
BRD2_Mmus        ------QQHQ--------SSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASAL
BRD2_Hsap        ------QQHQ--------SSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASAL
BRD3_Hsap        ------VPQH--------AGKKGKLSEHLRYCDSILREMLSKKHAAYAWPFYKPVDAEAL
BRD4_Hsap        ------QHPA--------PEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEAL
BRDT_Hsap        ------QQYN--------VVKTVKVTEQLRHCSEILKEMLAKKHFSYAWPFYNPVDVNAL
Y119C1B.8_Cele   ---------------------HQPLLPSMKPCLKLLNDFSTKKYQEFAWPFNEPVDAEQL
DDB0220693_Ddis  NGGSSERAQRSSRGRMGKAMRDVVLTPVFKRCLDLLEELFEHQHS---PPFLVAVDPYAL
DDB0220694_Ddis  -------SSS--------NYSDSMNEKNLTFCKGLINGMFKKKTS---LAFQRPVDPLAE
BRD_Spur         ------QHQK---------GKKGKLTAQLKYCYGVIKELMSKKHSAYAWPFFKPVDADVL
F13C5.2_Cele     ------SEDE---------AESDHLHDELKKCLSILKEFEKSTHDSFTFPFRKPVDVVLL
F57C7.1b_Cele    ------KHLV--------PRWQGKIPEWQKFCSKLLNEIHSVKNKGFAQVFYLPVDPIKL
AqueK041_Aque    --------SY---------GRKRPLTVQLRYCLSIVKDFFSKKHQASAWPFYNPVDVKGL
                                                *  ::. :           *  .**

BRDT_Mmus        GLHNYYDVVKNPMDLGTIKGKMDNQEYKDAYEFAADVRLMFMNCYKYNPPDHEVVAMART
BRD4_Mmus        GLHDYCDIIKHPMDMSTIKSKLESREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARK
BRD3_Mmus        ELHDYHDIIKHPMDLSTVKRKMDSREYPDAQGFAADIRLMFSNCYKYNPPDHEVVAMARK
BRD2_Mmus        GLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARK
BRD2_Hsap        GLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARK
BRD3_Hsap        ELHDYHDIIKHPMDLSTVKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARK
BRD4_Hsap        GLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARK
BRDT_Hsap        GLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARM
Y119C1B.8_Cele   GLHDYHKIIKEPMDLKSMKAKMESGAYKEPSDFEHDVRLMLRNCFLYNPVGDPVHSFGLR
DDB0220693_Ddis  GILDYFDVIKHPMDLGTIKASLIGGGYDTIDKFAEDCRLVFSNAKTYNPSTNPVHIMAQS
DDB0220694_Ddis  GIPDYFDVIKHPMDLGTIKGKLDNNGYSTIKDFAADVRLMFENALTYNADSSPVWKHAKT
BRD_Spur         GLHDYHEIIKTPMDMGTVKVKLENRDYKNANDFAANVRLIFTNCYKYNPPDHDVVGMARK
F13C5.2_Cele     GLTDYHEVIKKPMDMSTIRKKLIGEEYDTAVEFKEDFKLMINNCLTYNNEGDPVADFALQ
F57C7.1b_Cele    KIYDYLEVITNPMDLQTIKKKLDFKQYAEPEEFVHDINLMVDNCCKYNPKGSPAHSNALE
AqueK041_Aque    GLHDYLDIIKQPMDLTTLKKKLEDREYEDPSQFAADMRLIFTNCYKYNPPEHDVVKMARK
                  : :* .::. ***: ::: .:    *     *  : .*:. *.  **     .   .

BRDT_Mmus        LQDVFELHFAKI-PDEPIE--SMHACHLTT------NSAQALSRESSSEASSG-------
BRD4_Mmus        LQDVFEMRFAKM-PDEPEE--PVVTVSSPAVPPPTKVVAPPSSSDSSSDSSSDS------
BRD3_Mmus        LQDVFEMRFAKM-PDEPME--APALPAPTA-P----IVSKGAESSRSSEESSSD------
BRD2_Mmus        LQDVFEFRYAKM-PDEPLE--PGPLPVSTALP----PGLTKSSSESSSEESSSESSSEEE
BRD2_Hsap        LQDVFEFRYAKM-PDEPLE--PGPLPVSTAMP----PGLAKSSSESSSEESSSESSSEEE
BRD3_Hsap        LQDVFEMRFAKM-PDEPVE--APALPAPAA-P----MVSKGAESSRSSEESSSD------
BRD4_Hsap        LQDVFEMRFAKM-PDEPEE--PVVAVSSPAVPPPTKVVAPPSSSDSSSDSSSDS------
BRDT_Hsap        LQDVFETHFSKI-PIEPVE--SMPLCYIKT------DITETTGRENTNEASSE-------
Y119C1B.8_Cele   FQEVFDRRWAEL-GDSSSR--ASSVAPQSAPIAPTPK-VAKSSAPKEPKESRKEHKKE--
DDB0220693_Ddis  LEDVFEKGFPK-VLIEPPS--PPPKNVD------QE--KIE--K-LSN-----DL-----
DDB0220694_Ddis  LLNAFDQKFLQNFPNEKPPTYKPPPPTP------TP--IPT--Q-QQQQQSTSST-----
BRD_Spur         LQNVFEVKFAKM-PDEPLD--PSDLESDD-E-SK-D--ETKAMD-SPSDASASNS-----
F13C5.2_Cele     FRKKFAAKWKKEFPEDG--------------------------D-SFGQEKGEKE-----
F57C7.1b_Cele    LRSFFEQRWKLF-PRPGVD--PIIADSY--I--NQN--LVVNTD-LIEDERINSY-----
AqueK041_Aque    VQDIFEFKFARM-PEEPPP--APPKKTS--I-KM-K--TGGSSD-SSSSESEDND-----
                 . . *   :

BRDT_Mmus        -----------DASSEDSEDERVQHLAK--LQEQ-----------------LNAVHQQLQ
BRD4_Mmus        -----------DSSTDDSEEERAQRLAE--LQEQ-----------------LKAVHEQLA
BRD3_Mmus        ------------SGSSDSEEERATRLAE--LQEQTGCGAFQDQLLNVSSVQLKAVHEQLA
BRD2_Mmus        EEE-EEDEDEEESESSDSEEERAHRLAE--LQEQ-----------------LRAVHEQLA
BRD2_Hsap        EEEDEEDEEEEESESSDSEEERAHRLAE--LQEQ-----------------LRAVHEQLA
BRD3_Hsap        ------------SGSSDSEEERATRLAE--LQEQ-----------------LKAVHEQLA
BRD4_Hsap        -----------DSSTDDSEEERAQRLAE--LQEQ-----------------LKAVHEQLA
BRDT_Hsap        -----------GNSSDDSEDERVKRLAK--LQEQ-----------------LKAVHQQLQ
Y119C1B.8_Cele   ----------TTFEASGAKS---EDLMQ--INNA-----------------LSMIREREE
DDB0220693_Ddis  ----------------------------------------------------KNVTKELE
DDB0220694_Ddis  ------------------------------------------------------------
BRD_Spur         -----------SSESEDSEEEREKRLSE--LQEQ-----------------LKAVHEQLA
F13C5.2_Cele     -----------GSD-NEDDE---EEVDEKEKEEE-----------------V--------
F57C7.1b_Cele    -----------LSA-VKAEE---KKCAE--KLEQ-----------------LRSMSEGLY
AqueK041_Aque    -----------SSEESDSESERASQLSK--LQEQ-----------------VIMVSKQLA


BRDT_Mmus        VLSQV----------------PLRKLKKK--------NE-KSK-----------------
BRD4_Mmus        ALSQP----------------QQNKPKKK---------E-KDK-----------------
BRD3_Mmus        ALSQA----------------PVNKPKKK--------KE-KKE-----------------
BRD2_Mmus        ALSQG----------------PISKPKRK--------RE-KKE-----------------
BRD2_Hsap        ALSQG----------------PISKPKRK--------RE-KKE-----------------
BRD3_Hsap        ALSQA----------------PVNKPKKK--------KE-KKE-----------------
BRD4_Hsap        ALSQP----------------QQNKPKKK---------E-KDK-----------------
BRDT_Hsap        VLSQV----------------PFRKLNKK--------KE-KSK-----------------
Y119C1B.8_Cele   KLKAE----------------LAAA--------QAI-KDKLTS-----------------
DDB0220693_Ddis  KFKKD----------------DSNSINNNN------------------------------
DDB0220694_Ddis  ---ST----------------PTS-EKKRK------------------------------
BRD_Spur         ALSSQ----------------AHRKKKKK--------DK-DKT-----------------
F13C5.2_Cele     ------------------------------------------------------------
F57C7.1b_Cele    TIAMQ----------------RR-EAKLAGNTAPALAQNQLSQLEGLGISIKSTPMMIPE
AqueK041_Aque    ALSKKGGGGGTPTLGIDANFAPFLSPAPS--------KE-KKK-----------------


BRDT_Mmus        -------------RAP--KRKKVN------------------N-----------------
BRD4_Mmus        -------------KEK--KK---E--------K-HK------K-----------------
BRD3_Mmus        -------------KEK--KKKDKDKDKE----K-EK------H-----------------
BRD2_Mmus        -------------KKK--KRKA-E--------K-HR------G-----------------
BRD2_Hsap        -------------KKK--KRKA-E--------K-HR------G-----------------
BRD3_Hsap        -------------KEK--KKKDKEK--E----K-EK------H-----------------
BRD4_Hsap        -------------KEK--KK---E--------K-HK------R-----------------
BRDT_Hsap        -------------KEK--KKEKVN------------------N-----------------
Y119C1B.8_Cele   -------------VKN--RRED-NPNEPFPEK------LI--------------------
DDB0220693_Ddis  --------NNNNNYNN--NNNN-NNNNS----SSSSS-RS--------------------
DDB0220694_Ddis  ---------HDEHVKV--KEDT-NSAQPTSSSSNHTN-GE--------------------
BRD_Spur         -------------KKK--ERKDIEKEKE----ELEKAKELERQREKEMEEMREKERKLLE
F13C5.2_Cele     ------------------KEDN-AEEKPAEEP----------------------------
F57C7.1b_Cele    LISPALSVRSSSRAPVPKIIDD-IGPSPIKAR------KI--------------------
AqueK041_Aque    -------------KKD--KSSRKGKNKP-----VPS------------------------


BRDT_Mmus        -RDE---N-------PRKK----P--KQMKQKEKA--K-------------------IN-
BRD4_Mmus        -KEEVEEN----KKSKTKEL---P----PKKTKKNNSSNSN--------------VSKK-
BRD3_Mmus        -KAKSEEE----KKAKAAPA---A--KQAQ-QKKAPTKKANST-----------TTASR-
BRD2_Mmus        -RIGIDED----DKGPRAPR---P--PQPKKSKKAGGGGSNATTLSHPGFGTSGGSSNK-
BRD2_Hsap        -RAGADED----DKGPRAPR---P--PQPKKSKKASGSGGGSAALGPSGFGPSGGSGTK-
BRD3_Hsap        -KVKAEEE----KKAKVAPP---A--KQAQ-QKKAPAKKANST-----------TTAGR-
BRD4_Hsap        -KEEVEEN----KKSKAKEP---P----PKKTKKNNSSNSN--------------VSKK-
BRDT_Hsap        -SNE---N-------PRKM----C--EQMRLKEKS--K-------------------RN-
Y119C1B.8_Cele   --------NETRA--L--CTT---------QVGQNAS-SSS-------------ASSAAL
DDB0220693_Ddis  -----SS-RKSHSSGS--SSSHR--SGSSRS-SRGS--SSS--------------SS---
DDB0220694_Ddis  -----NA-SSSS----------S--SSSSKQSNNNNN-NNN--------------NN---
BRD_Spur         EKARDEERSKSASKRPRKPAKSTEDKAKPKKTNRPRK-NAK-------------TAEEKP
F13C5.2_Cele     ----------------------------------------E-------------QPDEKE
F57C7.1b_Cele    --------SKPRA--S--MASNV--SVPY-------T-PTG-------------NPRGRK
AqueK041_Aque    ------------TSTPLLPT------LQPKKSKSA-------------------------


BRDT_Mmus        QP----------KKK-------KPLLKSEEEDN--------------AKPMNYDE-KRQL
BRD4_Mmus        EPV--------PTKTK-----PPPTYESEEEDK--------------CKPMSYEE-KRQL
BRD3_Mmus        QLK--------KGGKQ-----ASASYDSEEEEE--------------GLPMSYDE-KRQL
BRD2_Mmus        LPK--------KSQKT-APPVLPTGYDSEEEEE--------------SRPMSYDE-KRQL
BRD2_Hsap        LPK--------KATKT-APPALPTGYDSEEEEE--------------SRPMSYDE-KRQL
BRD3_Hsap        QLK--------KGGKQ-----ASASYDSEEEEE--------------GLPMSYDE-KRQL
BRD4_Hsap        EPA--------PMKSK-----PPPTYESEEEDK--------------CKPMSYEE-KRQL
BRDT_Hsap        QP----------KKRK-Q---QFIGLKSEDEDN--------------AKPMNYDE-KRQL
Y119C1B.8_Cele   RNG--------RSKKAASARLYGYEFDSDDEDN--------------KMALTYEE-KRNL
DDB0220693_Ddis  --S--------SSSSSS-SSSSSSSSSSSNNKK--------------YPKVTTEE-KTKL
DDB0220694_Ddis  --N--------SN---S-TTNSSS-SSSSTTTT--------------QKKYSDEE-RRSL
BRD_Spur         KPKRTNSRRGGGRKKK-V--PTTGQLESDDEDT--------------AKPMSYDE-KRQL
F13C5.2_Cele     -EE--------DH--ED-EREEQEEEDSSDEEDGL----------------DDDDVRR--
F57C7.1b_Cele    -PK--------KSGRPK-KNIYSPATVSERISQQPPFEVTPYVSIYGRKVVGTND-KIEL
AqueK041_Aque    -------------KKR-T--PLNW-QPSSDEED--------------VKPMTYDE-KRQL
                                            *.                        :: :

BRDT_Mmus        SLDINKLPGDKLGRIVHIIQSREPSL-----RNSNPDEIEIDFETLKASTLRELEKYVLA
BRD4_Mmus        SLDINKLPGEKLGRVVHIIQSREPSL-----KNSNPDEIEIDFETLKPSTLRELERYVTS
BRD3_Mmus        SLDINRLPGEKLGRVVHIIQSREPSL-----RDSNPDEIEIDFETLKPTTLRELERYVKS
BRD2_Mmus        SLDINKLPGEKLGRVVHIIQAREPSL-----RDSNPEEIEIDFETLKPSTLRELERYVLS
BRD2_Hsap        SLDINKLPGEKLGRVVHIIQAREPSL-----RDSNPEEIEIDFETLKPSTLRELERYVLS
BRD3_Hsap        SLDINRLPGEKLGRVVHIIQSREPSL-----RDSNPDEIEIDFETLKPTTLRELERYVKS
BRD4_Hsap        SLDINKLPGEKLGRVVHIIQSREPSL-----KNSNPDEIEIDFETLKPSTLRELERYVTS
BRDT_Hsap        SLNINKLPGDKLGRVVHIIQSREPSL-----SNSNPDEIEIDFETLKASTLRELEKYVSA
Y119C1B.8_Cele   SNLINNLPNNQLNTIISIIQRRERSA--LMQQQLDDSEVELDFESLGDMCLREMGAFIKT
DDB0220693_Ddis  GAEITQLPVDLLPSILQIIHNTN-S----LPEQKPGSEVVIDLMKFDDDILRRLSKFVEQ
DDB0220694_Ddis  MERINELAPDDVQEVLNIIDP---N----AIKQA-DESLEIDMYQIDDKNLSQVESFINE
BRD_Spur         SLDINKLPGDKLGKVVHIIQSREPSL-----KDSTPDEIEIDFETLKPSTLRELEKYVMQ
F13C5.2_Cele     ------------------------------------------------------------
F57C7.1b_Cele    SERMASIPQMYITPILRIIQIGHHNTGKTITSLRSLCEEEIDFNDVSDDLVIELLDYLEM
AqueK041_Aque    SLDINKLPGVTLNRVVHIIQMRERTI-----KDGNPDEIEIDFETLKPATLRELEKYVNS


BRDT_Mmus        CLRKR----SLKPQAK--K--V--------------------------VRSKEELHSEKK
BRD4_Mmus        CLRKK----R-KPQAEK--VDVIAGSSKMKGFSSSESESTSESSSSDSEDSETEMAPKSK
BRD3_Mmus        CLQKK----QRKPLSTSGKKQA--------------------------AKSKEELAQEKK
BRD2_Mmus        CLRKK----PRKPYTI--RKPV--------------------------GKTKEELALEKK
BRD2_Hsap        CLRKK----PRKPYTI--KKPV--------------------------GKTKEELALEKK
BRD3_Hsap        CLQKK----QRKPFSASGKKQA--------------------------AKSKEELAQEKK
BRD4_Hsap        CLRKK----R-KPQAEK--VDVIAGSSKMKGFSSSESESSSESSSSDSEDSETEMAPKSK
BRDT_Hsap        CLRKR----PLKPPAK--K--I--------------------------MMSKEELHSQKK
Y119C1B.8_Cele   IPTLNGNGDDEKPKTS--SNPTSSGA----------------------TGSKGSSSLESK
DDB0220693_Ddis  YKNGEI-PQHALPLSA----PSSTHS----------------------SHSSSHDSSSNI
DDB0220694_Ddis  CFKK--------------------------------------------------------
BRD_Spur         CLRKR-----PKAYNK--GQ----------------------------TKSKQDAQKEKQ
F13C5.2_Cele     ----------HIPA-------------------------------------------STS
F57C7.1b_Cele    IQKDK-----AKAE-------------------------------------------QVR
AqueK041_Aque    VLKKQ-----KRPPTN--KS---------------------------------MDAAKKR


BRDT_Mmus        LEL-ERRLL---DVN-NQLN----CRK-----RQT-KRPAKVEKPPPPPPPPPPPPPPPE
BRD4_Mmus        KKGHTGRDQ---KKH-H-HHHHPQMQP-----APA-PV--PQQPP---------------
BRD3_Mmus        KEL-EKRLQ---DVS-GQLN----S-K-----KPT-KK--E--KS---------------
BRD2_Mmus        REL-EKRLQ---DVS-GQLN----STK-----KPP-KK--ASEKT---------------
BRD2_Hsap        REL-EKRLQ---DVS-GQLN----STK-----KPP-KK--ANEKT---------------
BRD3_Hsap        KEL-EKRLQ---DVS-GQLS----SSK-----KPA-RK--E--KP---------------
BRD4_Hsap        KKGHPGREQ---KKH-H-HHHHQQMQQ-----APA-PV--PQQPP---------------
BRDT_Hsap        QEL-EKRLL---DVN-NQLN----SRK-----RQT-KS----DKT---------------
Y119C1B.8_Cele   NGK-K---KK--------------------------------------------------
DDB0220693_Ddis  REI-EKLQKQLDRLGKGQQN----SSSSSSSSSHSKRI--SKPIS---------------
DDB0220694_Ddis  ------------------------------------------------------------
BRD_Spur         KEL-EDRLK---ELG-GPFP------K-----KAT-KK----AQQ---------------
F13C5.2_Cele     APV-AKH--------------------------PEA------------------------
F57C7.1b_Cele    QEL-EVKAKFYG----FEAY----DNKL-GTIPKTR------------------------
AqueK041_Aque    AEL-EKRLQ---DVS-GKLG----GGSG--MPKLP-KT--KKSKS---------------


BRDT_Mmus        LASGSRLTDSSSSS----------------------------------------------
BRD4_Mmus        ------------------------------------------------------------
BRD3_Mmus        ------------------------------------------------------------
BRD2_Mmus        ------------------------------------------------------------
BRD2_Hsap        ------------------------------------------------------------
BRD3_Hsap        ------------------------------------------------------------
BRD4_Hsap        ------------------------------------------------------------
BRDT_Hsap        --------QPSKAV----------------------------------------------
Y119C1B.8_Cele   ------------------------------------------------------------
DDB0220693_Ddis  --------KARGRKVISTSSSNLNNSSNNINNNNNNINNYNNNNNYNNNNNNNLNNNNNN
DDB0220694_Ddis  ------------------------------------------------------------
BRD_Spur         --------DALMNE----------------------------------------------
F13C5.2_Cele     ------------------------------------------------------------
F57C7.1b_Cele    ------------------------------------------------------------
AqueK041_Aque    --------DAKGSK----------------------------------------------


BRDT_Mmus        -----------------------------------GSGSG--SSSSS-SGSSSSSSSS--
BRD4_Mmus        ------------------------------------------------------------
BRD3_Mmus        ------------------------------------------------------------
BRD2_Mmus        ------------------------------------------------------------
BRD2_Hsap        ------------------------------------------------------------
BRD3_Hsap        ------------------------------------------------------------
BRD4_Hsap        ------------------------------------------------------------
BRDT_Hsap        -----------------------------------ENV----SRLSE-S-SSSSSSSS--
Y119C1B.8_Cele   --------------------------------------NFNMSESSDDE-TSNSRKRRKR
DDB0220693_Ddis  NINSNLNNNLNNNNNKDDIVIDGFKKENFSSIPEKDV-ETDISESS----DSESDSES--
DDB0220694_Ddis  ------------------------------------------------------------
BRD_Spur         -----------------------------------GG-RT--ERPLS-A-SSSSDSES--
F13C5.2_Cele     ------------------------------AMPE--------------------------
F57C7.1b_Cele    ------------------------------NMPP-PL-QHRMRSDS----PSPSASRT--
AqueK041_Aque    -----------------------------------DL-KS--SRLSD-S-SSSSDDDSAN


BRDT_Mmus        GSASSS-SDSSSSDSSDSEPEIFPKFTGVK-Q---N------------------------
BRD4_Mmus        ------------------------PPPQ--------------------------------
BRD3_Mmus        ------------------------------------------------------------
BRD2_Mmus        ------------------------------------------------------------
BRD2_Hsap        ------------------------------------------------------------
BRD3_Hsap        ------------------------------------------------------------
BRD4_Hsap        ------------------------PPPQ--------------------------------
BRDT_Hsap        ESESSS-SDLSSSDSSDSESEMFPKFTEVK-P---N------------------------
Y119C1B.8_Cele   ESSES-QSSSSSDDDSDDED--RPSIPR--------------------------------
DDB0220693_Ddis  GSSDS-SSSYSDSDFSDSDNDRRRNYNNSY-NNNNNNNNNNNSSNNFNNQNNSYNNSNNN
DDB0220694_Ddis  ------------------------------------------------------------
BRD_Spur         DASSST-SASSSSDNSESESGT-PKKMKKGIKVP-PLP----------------------
F13C5.2_Cele     ------------------------------------------------------------
F57C7.1b_Cele    GNQSS-DSDSASDDSSDDEPS--RSNS---------------------------------
AqueK041_Aque    EEESSSGTGSSTSSSSDEEKDVKPVQKART-----P------------------------


BRDT_Mmus        -------------------------------------------------DLPPKENIKQ-
BRD4_Mmus        -------------------------------------------------QPPPPPPPQQQ
BRD3_Mmus        ------------------------------------------------------------
BRD2_Mmus        ------------------------------------------------------------
BRD2_Hsap        ------------------------------------------------------------
BRD3_Hsap        ------------------------------------------------------------
BRD4_Hsap        -------------------------------------------------QPPPPPPPQQ-
BRDT_Hsap        -------------------------------------------------DSPSKENVKKM
Y119C1B.8_Cele   ------------------------------------------------------------
DDB0220693_Ddis  NNNNSSNNNNNNNNNNSNNNNSNNNNNNVNNN----------------------------
DDB0220694_Ddis  ------------------------------------------------------------
BRD_Spur         -------------------------------ANRQEMQRRLSGPGQAPITTPAGFHPETQ
F13C5.2_Cele     ------------------------------------------------------------
F57C7.1b_Cele    ------------------------------------------------------------
AqueK041_Aque    ------------------------------------------------------------


BRDT_Mmus        ------------------------------------------------------------
BRD4_Mmus        QQQPPPPPPPPSMPQQTAPAMKSSPPPFITAQVPVLEPQLPGSVFDPIGHFT-QPILHLP
BRD3_Mmus        ------------------------------------------------------------
BRD2_Mmus        ------------------------------------------------------------
BRD2_Hsap        ------------------------------------------------------------
BRD3_Hsap        ------------------------------------------------------------
BRD4_Hsap        QQQPPPPPPPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFT-QPILHLP
BRDT_Hsap        KNECIPPEGRTGV-T---------------------------------------------
Y119C1B.8_Cele   ------------------------------------------------------------
DDB0220693_Ddis  ------------------------------------------------------------
DDB0220694_Ddis  ------------------------------------------------------------
BRD_Spur         QQQPMSTGPGPS-PFS-------------------LGPQA---TGHPSGHPSGQPVQHPG
F13C5.2_Cele     ------------------------------------------------------------
F57C7.1b_Cele    ------------------------------------------------------------
AqueK041_Aque    ------------------------------------------------------------


BRDT_Mmus        ---------------------------IQSSVQ-----------DITSAEAP--------
BRD4_Mmus        QPELPPHLPQPPEHSTPPHLNQHAVVSPPA---LHNALPQQPSRPSNRAAALPPKPTRPP
BRD3_Mmus        ------------------------------------------------------------
BRD2_Mmus        ------------------------------------------------------------
BRD2_Hsap        ------------------------------------------------------------
BRD3_Hsap        ------------------------------------------------------------
BRD4_Hsap        QPELPPHLPQPPEHSTPPHLNQHAVVSPPA---LHNALPQQPSRPSNRAAALPPKPARPP
BRDT_Hsap        --------------------------QIGYCVQ-----------DTTSANTT--------
Y119C1B.8_Cele   ----------------------------------KSGQPPSTSR----------------
DDB0220693_Ddis  ----------NNNHNNNNHNNN--INNNNNNINNNTTQPSPSQQ----ST----------
DDB0220694_Ddis  ------------------------------------------------------------
BRD_Spur         QPS--PRLTNGQNHIPAP---------------RHSSLPALPDRPSNKAAPLQKRSQRKV
F13C5.2_Cele     ------------------------------------------------------------
F57C7.1b_Cele    -----------------------------------NVAG---------------------
AqueK041_Aque    ---------------------------------QATSKPIAPAYQTTSAASIIGRSQSK-


BRDT_Mmus        ------------------------------------------------------------
BRD4_Mmus        --------------------------AVSPALAQP-PLLPQPPMAQPPQVLLEDEEPPAP
BRD3_Mmus        ------------------------------------------------------------
BRD2_Mmus        ------------------------------------------------------------
BRD2_Hsap        ------------------------------------------------------------
BRD3_Hsap        ------------------------------------------------------------
BRD4_Hsap        --------------------------AVSPALTQT-PLLPQPPMAQPPQVLLEDEEPPAP
BRDT_Hsap        ------------------------------------------------------------
Y119C1B.8_Cele   ------------------------------------------------------------
DDB0220693_Ddis  ------------------------------------------------------------
DDB0220694_Ddis  ------------------------------------------------------------
BRD_Spur         LTSPLTSPGPLTSPANTRGSTTTAFPLPSPTLPQTKPAVVAPPQLQPPAVS---KAPPAT
F13C5.2_Cele     ------------------------------------------------------------
F57C7.1b_Cele    ------------------------------------------------------------
AqueK041_Aque    ------------------------------------------------------------


BRDT_Mmus        -------------------------------LAQQSTA-PCGAPG---------------
BRD4_Mmus        PLT-----SMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPPPPHPSVQQQQLQPQPP
BRD3_Mmus        ------------------------------------------------------------
BRD2_Mmus        ------------------------------------------------------------
BRD2_Hsap        ------------------------------------------------------------
BRD3_Hsap        ------------------------------------------------------------
BRD4_Hsap        PLT-----SMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPPPPHPSVQQ-QLQQQPP
BRDT_Hsap        -------------------------------LVHQTTP-SHVMPP---------------
Y119C1B.8_Cele   ------------------------------------------------------------
DDB0220693_Ddis  ------------------------------------------------------------
DDB0220694_Ddis  ------------------------------------------------------------
BRD_Spur         PPAMAPSAPVAPQPAPVAIPKPKPEPVVKPSKPAPSQTPPAAVPPP--SSTK--------
F13C5.2_Cele     ------------------------------------------------------------
F57C7.1b_Cele    ------------------------------------------------------------
AqueK041_Aque    ------------------------------------------------------------


BRDT_Mmus        -----------------------------------------------------K------
BRD4_Mmus        PPPPPQPQPPPQQQHQPPPRPVHLPSMPFSAHIQ--QPPPPP-GQQPTHPPPGQQPPPPQ
BRD3_Mmus        ------------------------------------------------------------
BRD2_Mmus        ------------------------------------------------------------
BRD2_Hsap        ------------------------------------------------------------
BRD3_Hsap        ------------------------------------------------------------
BRD4_Hsap        PPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTHIQ--QPPPPQ-GQQPPHPPPGQQPPPPQ
BRDT_Hsap        -----------------------------------------------------N------
Y119C1B.8_Cele   ------------------------------EWNQSSAPPPRM-GGMGG------------
DDB0220693_Ddis  ------------------------------SLTNEPIKPPTILQTVKK--PAL--PVTG-
DDB0220694_Ddis  ------------------------------------------------------------
BRD_Spur         ----PLPQHPPPQQHPSRHSPQPLPQQQATSKPQSKPPPPTD--IPKPQPPAAQRPIPAD
F13C5.2_Cele     ------------------------------------------------------------
F57C7.1b_Cele    ------------------------------------------------------------
AqueK041_Aque    ------------------------------------------------------------


BRDT_Mmus        ------------------------------------------------------------
BRD4_Mmus        PAK-----PQQVIQHHPSPR-------------------------------------HHK
BRD3_Mmus        ------------------------------------------------------------
BRD2_Mmus        ------------------------------------------------------------
BRD2_Hsap        ------------------------------------------------------------
BRD3_Hsap        ------------------------------------------------------------
BRD4_Hsap        PAK-----PQQVIQHHHSPR-------------------------------------HHK
BRDT_Hsap        ------------------------------------------------------------
Y119C1B.8_Cele   -----------QP-----------------------------------------------
DDB0220693_Ddis  ----------SVASWSFD------------------------------------------
DDB0220694_Ddis  ------------------------------------------------------------
BRD_Spur         --TKKTAPPRSVTPPSPPPQVKPEVPSLIQQPTLIPKVEDNPMSFMVGDEDLEGEGESPS
F13C5.2_Cele     ------------------------------------------------------------
F57C7.1b_Cele    ------------------------------------------------------------
AqueK041_Aque    ------------------------------------------------------------


BRDT_Mmus        ------------------------------HSQQMLGCQVTQHLQAT-E-----------
BRD4_Mmus        SDPYSAGHLREAPSP------------LMIHSPQMPQFQSLTHQSPPQQNVQPKKQVKGR
BRD3_Mmus        ------------------------------------------------------------
BRD2_Mmus        ------------------------------------------------------------
BRD2_Hsap        ------------------------------------------------------------
BRD3_Hsap        ------------------------------------------------------------
BRD4_Hsap        SDPYSTGHLREAPSP------------LMIHSPQMSQFQSLTHQSPPQQNVQPKK-----
BRDT_Hsap        ------------------------------HHQLAFNYQELEHLQTV-K-----------
Y119C1B.8_Cele   ------------------------------------------------------------
DDB0220693_Ddis  ------------------------------------------------------------
DDB0220694_Ddis  ------------------------------------------------------------
BRD_Spur         TSPVMTGHKTEESNGSSHPEGGMPSSASSENLSKMEQKASSKDKKPPAVSKAPPATP---
F13C5.2_Cele     ------------------------------------------------------------
F57C7.1b_Cele    ------------------------------------------------------------
AqueK041_Aque    ------------------------------------------------------------


BRDT_Mmus        --------------------------------NTA-------------------------
BRD4_Mmus        AEPQPPGPVMGQGQGCPPASPAAVPMLSQELRPPSVVQPQPLVVVKEEKIHSPIIRSEPF
BRD3_Mmus        ------------------------------------------------------------
BRD2_Mmus        ------------------------------------------------------------
BRD2_Hsap        ------------------------------------------------------------
BRD3_Hsap        ------------------------------------------------------------
BRD4_Hsap        ----------------------------QELRAASVVQPQPLVVVKEEKIHSPIIRSEPF
BRDT_Hsap        --------------------------------NIS-------------------------
Y119C1B.8_Cele   ------------------------------------------------------------
DDB0220693_Ddis  ------------------------------------------------------------
DDB0220694_Ddis  ------------------------------------------------------------
BRD_Spur         ----------------------------PAMAPSAPVAPQPAPVAIPKPKPEPVVKPSKP
F13C5.2_Cele     ------------------------------------------------------------
F57C7.1b_Cele    ------------------------------------------------------------
AqueK041_Aque    ------------------------------------------------------------


BRDT_Mmus        ---------------------------------------SVQTQPLSG------------
BRD4_Mmus        STSLR-----------------PEPPKHPENIKAPVHLP---------------------
BRD3_Mmus        ------------------------------------------------------------
BRD2_Mmus        ------------------------------------------------------------
BRD2_Hsap        ------------------------------------------------------------
BRD3_Hsap        ------------------------------------------------------------
BRD4_Hsap        SPSLR-----------------PEPPKHPESIKAPVHLP---------------------
BRDT_Hsap        ---------------------------------------PLQILPPSG------------
Y119C1B.8_Cele   ---------------------------------------PMSRVPASS------------
DDB0220693_Ddis  ---------------------------------------PTNNKESSS------------
DDB0220694_Ddis  ------------------------------------------------------------
BRD_Spur         APSQTPPAAVPPPSSTKPLPQHPPPQQHP-SRHSPQPLPQQQATSKPQSKPPPPTDIPKP
F13C5.2_Cele     ------------------------------------------------------------
F57C7.1b_Cele    ---------------------------------------PRRALELSG------------
AqueK041_Aque    --------------------------------------SSLTTVPAGGAVAPPPTK----


BRDT_Mmus        -----------DCK----------------------------------------------
BRD4_Mmus        --------QRPEMK----------------------------------------------
BRD3_Mmus        ------------------------------------------------------------
BRD2_Mmus        ------------------------------------------------------------
BRD2_Hsap        ------------------------------------------------------------
BRD3_Hsap        ------------------------------------------------------------
BRD4_Hsap        --------QRPEMK----------------------------------------------
BRDT_Hsap        -----------DSE----------------------------------------------
Y119C1B.8_Cele   -----------STSVS--------------------------------------------
DDB0220693_Ddis  -----------SSSTS--------------------------------------------
DDB0220694_Ddis  ------------------------------------------------------------
BRD_Spur         QPPAAQRPIPADTKKTAPPRSVTPPSPPPQVKPEVPSLIQQPTLIPKVEDNPMSFMVGDE
F13C5.2_Cele     ------------------------------------------------------------
F57C7.1b_Cele    -----------NSSSA--------------------------------------------
AqueK041_Aque    --------------------DAAPPSP---------------------------------


BRDT_Mmus        ------------RVLLGPPVVHT------------SA-E-SLTVLE--------------
BRD4_Mmus        ------------PVDIGRPVIRPPEQSAPPPGA----PDKDKQKQE--------------
BRD3_Mmus        --------------------------GSAPSGG----PSRL-------------------
BRD2_Mmus        ------------------------ES-SAQQVA----VSRL-------------------
BRD2_Hsap        ------------------------ESSSAQQVA----VSRL-------------------
BRD3_Hsap        --------------------------GSAPSGG----PSRL-------------------
BRD4_Hsap        ------------PVDVGRPVIRPPEQNAPPPGA----PDKDKQKQE--------------
BRDT_Hsap        ------------QLSNGITVMHP------------SG-DSDTTMLE--------------
Y119C1B.8_Cele   --------------AIGK---------------NNAA--ASSNSYR--------------
DDB0220693_Ddis  ---------------------------------STSS--TSNTTLTPIIQQSSLTHASSP
DDB0220694_Ddis  ------------------------------------------------------------
BRD_Spur         DLEGEGESPSTSPVMTGHKTEESNGSSHPEGGMPSSASSENLSKME--------------
F13C5.2_Cele     ------------------------------------------------------------
F57C7.1b_Cele    ---------------------------------STPA--GPSK-AQ--------------
AqueK041_Aque    -------------------------------GF-----------QE--------------


BRDT_Mmus        ----------PECHAPAQKDIKIKN--ADSWKSLGK--P--VKAS--SVLKSSDELFNQF
BRD4_Mmus        ----------PKTPVAPKKDLKIKN--MGSWASLVQKHP--TTPS--STAKSSSDSFEHF
BRD3_Mmus        ----------------------------SSSS----SSE--SASS--SSSGSSSDS----
BRD2_Mmus        ----------------------------SASS---SSSD--SSSS--SSSSSSSDT----
BRD2_Hsap        ----------------------------SASS---SSSD--SSSS--SSSSSSSDT----
BRD3_Hsap        ----------------------------SSSS----SSE--SGSS--SSSGSSSDS----
BRD4_Hsap        ----------PKTPVAPKKDLKIKN--MGSWASLVQKHP--TTPS--STAKSSSDSFEQF
BRDT_Hsap        ----------SECQAPVQKDIKIKN--ADSWKSLGK--P--VKPS--GVMKSSDELFNQF
Y119C1B.8_Cele   ----------YRCFFVRKLNLKISN--KKKWKSKKN--S--TNLVFRSSKTCTSTSTNII
DDB0220693_Ddis  ISSSTFVSFSSSSSTPPTNNLSPPSPGLPNSPSINS--P--SSPS--ANNNNTDSAWNHF
DDB0220694_Ddis  ------------------------------------------------------------
BRD_Spur         ----------QKASSKDKKDMKLPN--RYSWSNLANT-PSSTKPS-SKPTKTSHHSFELF
F13C5.2_Cele     -------------------------P----------------------------------
F57C7.1b_Cele    -------------------------P----------------------------------
AqueK041_Aque    ----------PIE---------------------M----GGVK-K-R-AIPSADSSFAQF


BRDT_Mmus        RKAAIEKEVKART----QEQMRKHLEHNAK--DPKVSQENQ--REPGSGLTLESLSSKVQ
BRD4_Mmus        RRAAREKEEREKALK-AQAE---HAEKE--KERLRQERMRS--REDEDALEQARRAHEEA
BRD3_Mmus        ------------------------------------------------------------
BRD2_Mmus        ------------------------------------------------------------
BRD2_Hsap        ------------------------------------------------------------
BRD3_Hsap        ------------------------------------------------------------
BRD4_Hsap        RRAAREKEEREKALK-AQAE---HAEKE--KERLRQERMRS--REDEDALEQARRAHEEA
BRDT_Hsap        RKAAIEKEVKART----QELIRKHLEQNTK--ELKASQENQ--RDLGNGLTVESFSNKIQ
Y119C1B.8_Cele   -KTSGSTE---TTVK-TKENGRNQQR------RLRLDHQRK--ANPG---------MVKT
DDB0220693_Ddis  KAKNITLKQKEKERVLQEEVLRKEREEKEE--ELKKEEEKK--RI-----------EMEE
DDB0220694_Ddis  ------------------------------------------------------------
BRD_Spur         KKAAKEKEERTRQIK-QQEEMRKQQKHLQEQERARQERERQ--RE-----------KEED
F13C5.2_Cele     ------------------------------------------------------------
F57C7.1b_Cele    ------------------------------------------------------------
AqueK041_Aque    KKQALENAEREKANK-QQEDLRKQQIMLMQQNKKETESKSNTASP-----------VGGG


BRDT_Mmus        DKSLEEDQSEQQPPSEA-QD------------------VSKLWLLKDRNLAREKEQERRR
BRD4_Mmus        RRRQEQQQQQQQQRQEQQQQQQQAAAVAAASAPQAQSSQPQSMLDQQRELARKREQERRR
BRD3_Mmus        ------------------------------------------------------------
BRD2_Mmus        ------------------------------------------------------------
BRD2_Hsap        ------------------------------------------------------------
BRD3_Hsap        ------------------------------------------------------------
BRD4_Hsap        RRRQEQQQQQRQ--EQQQQQQQQAAAVAAAATPQAQSSQ<