CG5790_Dmel FDVHCRIGSGTFSTVLLGTLQRERG----------------------LVETQRRRFAIKH
CG8655_Dmel FDVHSRIGNGTFSTVLLGTLRRESH----------------------LPDSLRRKFAIKH
CDC7_Mmus FKIKDKIGEGTFSSVYLATAQLQ--------------------------EGHEEKIALKH
C34G6.5_Cele ------------------------------------------------------------
CDC7_Scer YKLIDKIGEGTFSSVYKAKDITGKITK--------------KFAS-HFWNYGSNYVALKK
CDC7_Hsap FKIEDKIGEGTFSSVYLATAQLQ--------------------------VGPEEKIALKH
Cdc7_Ddis YRILEKIGQGTFSGVYKSVCIDGP--------------------------NIGLIVALKR
7318_Tthe YLVNKELGRGGYGVVYKAYEYRDGV------------------------VNKKKKFAIKI
Cdc7_Spur FTVLDKIGEGTFSSVYRATLKKT--------------------------PDCNQEFALKH
CC1G_08833_Ccin YKLLDRLGTGTFSSVYKALDLRYHEYDNSPWLGHHPEESSAHFQSVPRPEGSRVFVAIKR
AqueK154_Aque FNVLSKLGEGTFSSVYLASVKTD----------------------------SSVMVALKH
CDC7_b_Smoe YRIEGVEGSGAYSVVFKARRFGDG-----------------------------RLFAIKC
CDC7_a_Smoe YRIEGVEGSGAYSVVFKARRFGDG-----------------------------RLFAIKC
GK046_Glam YKITQHVGKGAFSKVFLAYTPE------------------------------FQRRAIKR
CG5790_Dmel HNP--------------------TNHPERILRELECMYR------------------IGG
CG8655_Dmel HIP--------------------TSHPDRIMKELQCMTK------------------MGG
CDC7_Mmus LIP--------------------TSHPMRIAAELQCLTV------------------AGG
C34G6.5_Cele ---------------------------SMLSIELELLSE------------------LGG
CDC7_Scer IYV--------------------TSSPQRIYNELNLLYI------------------MTG
CDC7_Hsap LIP--------------------TSHPIRIAAELQCLTV------------------AGG
Cdc7_Ddis VAP--------------------TSSPARILNEIHSLLR------------------VGG
7318_Tthe NFQ--------------------TVSPELIFSEIAFLTL------------------LKG
Cdc7_Spur IIP--------------------TSHPSRILSELSCLVR------------------IGG
CC1G_08833_Ccin IYV--------------------TSGPERIRNELFIMET------------------CRG
AqueK154_Aque IIP--------------------TSSTTRIENEIRCLKI------------------MGG
CDC7_b_Smoe ALFLSISFGPGLLLTILTGPLQGDKIAASVDKEIKLLKLFGWAYLYSRKISFDVSALHRG
CDC7_a_Smoe ALFLCIFFGPGLLLTILTGPLQGDKIAASVDKEIKLLKL------------------FGG
GK046_Glam IRL--------------------TAKPHQLLKEIEFLRR------------------LEG
: *: : *
CG5790_Dmel VENVIGINCCIRYND---NVAFIMPYMTHDRFHDIYR--SLNFPEIRDYLRNLLIALRHV
CG8655_Dmel KENVVGIHCCMRYDA---SAAFVMPFMAHDRFQDFYT--RMDVPEIRQYMRNLLVALRHV
CDC7_Mmus QDNVMGLKYCFRKND---HVVIAMPYLEHESFLDILN--SLSFQEVREYMYNLFVALKRI
C34G6.5_Cele HFNIVKLFEFFHFNG---SVAIVLEHFPHCTATELLFHSKRDLSFALSYFRNLLYAVAYL
CDC7_Scer SSRVAPLCDAKRVRD---QVIAVLPYYPHEEFRTFYR--DLPIKGIKKYIWELLRALKFV
CDC7_Hsap QDNVMGVKYCFRKND---HVVIAMPYLEHESFLDILN--SLSFQEVREYMLNLFKALKRI
Cdc7_Ddis HYNVSALFGALRYKD---QVTLILPFFEHDSFKDYFF--QMSNENIKHYLYALFDSLRHI
7318_Tthe QPCTPQMVDLFTQEE---KTHIVIEYFKYEPFIKFFA--ESNMEEIKHYIYQMLLAVKTL
Cdc7_Spur CHNVMGVKLTVREKD---NIVIVMPHFKHNKFQDFYH--DMTVKEVQDYLRALFIALRRV
CC1G_08833_Ccin ARHVSQLITAFRHHD---QVAIVMPYHRNEDFRRPTR--MTD-----------------K
AqueK154_Aque KDNVIPIHASLRFQD---HTVLILPYFSHDRFIDYLP--TLTAEETRQYMHALFLALRNV
CDC7_b_Smoe KHSIIRLEEVIRDGE---KQYLVLEHVEYDSIQSLKK--DISMNDLRSYGFHLFKALNYM
CDC7_a_Smoe KHSIIRLEEVIRDGE---KKYLVLEHVEYDSIQSLKK--DISMNDLRSYGFHLFKALNYM
GK046_Glam KSHIVQIKEI-RFSDATLQTTVITSYSDTDDFKSVIL--DFTPREIQAYMRSILTALSHL
: .
CG5790_Dmel HKF-------------------NVIHRDVKP--SNILYNRRTG--------KFLLCDFGL
CG8655_Dmel HKF-------------------DVIHRDVKP--SNFLYNRRRR--------EFLLVDFGL
CDC7_Mmus HQF-------------------GIVHRDVKP--SNFLYNRRLK--------KYALVDFGL
C34G6.5_Cele HHN-------------------GYVHRDIKL--SNFLYSPQTQ--------RFRLVDFGL
CDC7_Scer HSK-------------------GIIHRDIKP--TNFLFNLELG--------RGVLVDFGL
CDC7_Hsap HQF-------------------GIVHRDVKP--SNFLYNRRLK--------KYALVDFGL
Cdc7_Ddis HQN-------------------NICHRDVKP--TNFLYSIKNN--------SFLLIDFGL
7318_Tthe KSM-------------------GIYHRDVKP--GNFLYNTAEK--------KGILIDYGL
Cdc7_Spur HKF-------------------NVIHRDVKP--GNFLYNRHSR--------KYALVDFGL
CC1G_08833_Ccin HHC-------------------NKIMDDKPPVLGACLHTQPTEQYPHGHIRKKHQYDENL
AqueK154_Aque HMH-------------------HIIHRDIKP--SNFLYHRASK--------RFQLIDFGL
CDC7_b_Smoe HQK-------------------NVIHRDVKP--GNFLYSRKSK--------VGHLVDFNL
CDC7_a_Smoe HQKVGLFFFFFVNTVFTFELLQNIIHRDVKP--GNFLYSRKSK--------VGHLVDFNL
GK046_Glam EKL-------------------KIIHRDIKP--GNFLFERKTG--------KGLLIDFGL
. * *. * .*
CG5790_Dmel AQ-RIAD-----------------------------------------------------
CG8655_Dmel AQ-HVNPP----------------------------------------------------
CDC7_Mmus AQ-GTRDTKIELLKFVQSEAQ-----------QEDCSRNKYHGVVGHKGLLSRPAPKTVD
C34G6.5_Cele AT-VDRSKNECSRSHAVAA-----------------------------------------
CDC7_Scer AE-AQMDY----------------------------------------------------
CDC7_Hsap AQ-GTHDTKIELLKFVQSEAQ-----------QERCSQNKSHIITGNKIPLSGPVPKELD
Cdc7_Ddis AQ-EMPNSNSNSNSNSNSNSN-----------SNSNSNSNSNSNNNNNN-----------
7318_Tthe SE-IDDKFIENL-KEQQRQKK-----------D---------------------------
Cdc7_Spur AQ-AVPTRSSAKTTV-KPSTVGGVLHHDTPRPPQARKNTRRAVSTSE-------------
CC1G_08833_Ccin VKEGQMDA----------------------------------------------------
AqueK154_Aque AH-HESSSGNKSETRSKGDSK---------------------------------------
CDC7_b_Smoe AL-EQDLAGRAK-RRLPNQNR-----------QMQCSLPADITFTEER------------
CDC7_a_Smoe ------------------------------------------------------------
GK046_Glam AQ-TLREVREFPLLRGQSKSR-----------KGVIHINLDRLMRQS-------------
CG5790_Dmel ------------------------------------------------------------
CG8655_Dmel ------------------------------------------------------------
CDC7_Mmus QQCTPKTSV--KRSYT--QVHIKQGKDGK-ERSVGLSVQRSVFGERNFNIHSS-------
C34G6.5_Cele ------------------------------------------------------------
CDC7_Scer ------------------------------------------------------------
CDC7_Hsap QQSTTKASV--KRPYTNAQIQIKQGKDGK-EGSVGLSVQRSVFGERNFNIHSS-------
Cdc7_Ddis NNNNTNNNF--N--GNNSN----------NDFNNFINMNNSNSNNNNNN-NSNNNNNNNN
7318_Tthe ------------------------------------------------------------
Cdc7_Spur NKALTRVEP--KRTQSESHSKV--PKLVELDPNTFHSTDKSSRDRSNHRLDSV------N
CC1G_08833_Ccin ------------------------------------------------------------
AqueK154_Aque ----------------------------------------------LNNIHV-------A
CDC7_b_Smoe -NALLQ-------------------------------CSRLEA----------------D
CDC7_a_Smoe ------------------------------------------------------------
GK046_Glam NQYLTDLTAQGEETYYTARMSLKEGQ----------------------------------
CG5790_Dmel ------------------------------------------------------------
CG8655_Dmel ------------------------------------------------------------
CDC7_Mmus ---ISHESPA----------EKLIKQSKTVDIIS--RK----L-ATKK--TAISTKAMNS
C34G6.5_Cele ------------------------------------------------------------
CDC7_Scer ------------------------------------------------------------
CDC7_Hsap ---ISHESPA----------VKLMKQSKTVDVLS--RK----L-ATKK--KAISTKVMNS
Cdc7_Ddis NNNNNNNNNSNNNNNSNNSQEEIILPS------------------TN---EN--------
7318_Tthe -------------------------------------PEIQ----------KKI------
Cdc7_Spur EDDLKKKVPAMIARGSENTAEVIIAPSKEKKPTKPPKP----VILTRN-CAAIATRGVTR
CC1G_08833_Ccin -------------------RKKS-----------------------K-------------
AqueK154_Aque AE------P----------------------LRK--RK----L-SSKR--SS--------
CDC7_b_Smoe AE------D----------FDKMLKRLRSADYKS--QEHMQPVQMTRKPLREYVTSNIPS
CDC7_a_Smoe ------------------------------------------------------------
GK046_Glam ------TVPA----------AH----------------------VTGS--NAAASTNVVR
CG5790_Dmel ----------------------------------DEMHASRAGTPGYRPPEVLLRYPKQS
CG8655_Dmel -------------------------------AK-KEVHASRAGTPGYRPPEVLLKYPDQT
CDC7_Mmus -VMRETARSCP--AVLTCDCYGSDRVCSVCLSR-RQQVAPRAGTPGFRAPEVLTKCPDQT
C34G6.5_Cele -------MERD--P-ECCSCKGTSSPCMFCRGKPKRENYNVVGTPGVRAPELLFGIGLCH
CDC7_Scer -----------------------------KSTR-RIKRANRAGTRGFRAPEVLMKCGAQS
CDC7_Hsap AVMRKTASSCP--ASLTCDCYATDKVCSICLSR-RQQVAPRAGTPGFRAPEVLTKCPNQT
Cdc7_Ddis GTTTSNASSTS--NTTSSSSSSSNKSKNLRNDP-KPQPAPRAGTRGFRAPEVLLKYNKQT
7318_Tthe ------------------DLYQNIKKC-----E-KIVGKNKIGTESFMPLESILRYRDQG
Cdc7_Spur -RLQDMPK-TP--Q-GICGCYGLPRVCDVCMAK-KNQVAPRAGTPGFRSPEVLLKCPDQT
CC1G_08833_Ccin -----------------MHAHSVGI--LDKDTR-MPMKANRAGTRGFRAPEVLLKCGQQS
AqueK154_Aque RSTDERAVSNS--GLLCPTRHSMSEVCGFCLGR-NGQVAARAGTPGFRAPEVLLKCSHQT
CDC7_b_Smoe NQARKRVGLKP---TLVTDIKPLATIYPSCSLD-RR-RIACVGTKGYGAPEVLLGSP-QT
CDC7_a_Smoe ------------------------------------------------------------
GK046_Glam -PNDDTAERLPIAGYINK---------DHSTFR-PLPPSAHSGTHGYRAPEILVPVRNQD
CG5790_Dmel TAVDVWAAGVIMLSLLSGLHPFFKAP----------------------HDCGALAEIINL
CG8655_Dmel TAVDVWAAGVIFLSIMSTVYPFFKAP----------------------NDFIALAEIVTI
CDC7_Mmus TAIDMWSAGVIFLSLLSGRYPFYKAS----------------------DDLTALAQIMTI
C34G6.5_Cele PSIDIFSCGIVLLSLVSVKHPFFMPK----------------------DETENIMHLAFL
CDC7_Scer TKIDIWSVGVILLSLLGRRFPMFQSL----------------------DDADSLLELCTI
CDC7_Hsap TAIDMWSAGVIFLSLLSGRYPFYKAS----------------------DDLTALAQIMTI
Cdc7_Ddis TAIDIWSVGVILLCMISGRYPFFISP----------------------DDMTSLAEIVSI
7318_Tthe YQVDIWPIGVVFLQFLLKKYNIFNNVRMQNKPNQNKNNHNKSGQIKNTYFITFILELANI
Cdc7_Spur TAVDMWAAGVIFLSILSGRYPFFRAP----------------------DDFTALAQIMSI
CC1G_08833_Ccin GAVDVWSAGIILLFFLTRKFPIFQSN----------------------DDIEALMELAAI
AqueK154_Aque TGKEMV------------------------------------------------------
CDC7_b_Smoe VKVDIWSAAVTLLQIATGRLPFSNGG-----------------------VPKTIQEIAKL
CDC7_a_Smoe ------------------------------------------------------------
GK046_Glam CKIDSWSVGVILIQILTGKTSLFRGNP--------------------TVDIYEILAIRSI
CG5790_Dmel FGDMPVRK----------------------------------------------------
CG8655_Dmel FGDQA-------------------------------------------------------
CDC7_Mmus RGSRETIQAAKAFGKSVLCS-KEVPAQDLR---ALCERLRG-------------------
C34G6.5_Cele LGSETIEKMAHSEGLRVTLS-EKLPPADYY---HLIL-----------------------
CDC7_Scer FGWKELRKCAWSD-----------------------------------------------
CDC7_Hsap RGSRETIQAAKTFGKSILCS-KEVPAQDLR---KLCERLRG-------------------
Cdc7_Ddis IGTKKIVDIAHLLEKKISIS-HSIPPTPWR---DLSRRLRS-------------------
7318_Tthe FGSDAVIELCRKYEYEVSLP-NELPKGPI-------------------------------
Cdc7_Spur MGTEETTEAAKVNGKNLLCN-VKLPAMELK---TMCRQLRL-------------------
CC1G_08833_Ccin FGRKKMESVATLHARKFATNVPDIPQDQVK-WTTMIEKLNPDLLTPPTPKEHFYPYTLPS
AqueK154_Aque ------------------CC-PDVPAADLK---CLCHALRK-------------------
CDC7_b_Smoe CGTRELKELVGTK---KTCF-LEVAVQELK---HDCDGT---------------------
CDC7_a_Smoe ------------------------------------------------------------
GK046_Glam IGTDRFIQGMSRLKADFSLT-AGAPMPQAIALEELAEWY---------------------
CG5790_Dmel ------------------------------------------------------------
CG8655_Dmel ------------------------------------------------------------
CDC7_Mmus -------LD------STTP-RSASGP-PGNASYDP--AASKNTDHKAS-RVQAAQAQHSE
C34G6.5_Cele ------------------------------------------------------------
CDC7_Scer ------------------------------------------------------------
CDC7_Hsap -------MD------SSTP-KLTSDI-QGHASHQP--AISEKTDHKASCLVQTPPGQYSG
Cdc7_Ddis -----------------------------ESS----------------------------
7318_Tthe -------------------------------NFK--------------------------
Cdc7_Spur -------GA-----VQRRQ-SKSSQS-NGESSKRRRRSINQTSPPKE-ETVGSPESQRSV
CC1G_08833_Ccin YRAKLRQEEERRQQRQQDPHRTPTRSSRHEQSQED--DIESDAAPPTSHLTSSSPLLFPR
AqueK154_Aque -------SN------QQTT-SRPTKK-KRPSSPD--------------------------
CDC7_b_Smoe -------------------------------SIS--------------------------
CDC7_a_Smoe ------------------------------------------------------------
GK046_Glam ------------------------------------------------------------
CG5790_Dmel ---------------------------TAPAVAYDLLSRLLEVNPQKRITAEEALKHPFF
CG8655_Dmel ----------------------------IPPSAYDLLDRLLEINPHKRITAEEALKHPFF
CDC7_Mmus DSLY-KRDNDGYWSHPKDCTSNSEGWDSVPDEAYDLLDKLLDLNPASRITAEAALLHAFF
C34G6.5_Cele ---------------------------------------C------LRFGFDHVRRHCSS
CDC7_Scer -----------------------------HYWCFQVLEQCFEMDPQKRSSAEDLLKTPFF
CDC7_Hsap NSFK-KGDSNSCEHCFDEYNTNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFF
Cdc7_Ddis -----------------------CDKQDVPVELYDLLERCLDPNPLTRITASEALLHP-F
7318_Tthe ---------------------EIIKKEEFDDVANDLLTKLIALDQADRISVEDALNHPFF
Cdc7_Spur GSV----------------GSEEGLVDQFPDTAYDLLGRLLELDPHKRITAEQALKHPFL
CC1G_08833_Ccin SSPANNVDEDSPS---PGSDSLQTSWEQGIRDAMDLVTKLLEPESVKRITPAAALAHPFL
AqueK154_Aque ---------------------PEVDPDSFPSSAFDLLYKCLDVNPKTRLTATLALKHPFF
CDC7_b_Smoe ---------------------EWIKSPELPSSFLDLISKCLKANPEERISAREAMQHEFF
CDC7_a_Smoe -----------------------------------------------------------A
GK046_Glam ---------------------NPDLLAVLPASCFDLCRKLLEFDPESRLSATEALSHPFL