FGFR4_Hsap MRLL----------------------LALLGVLLSV--P---------------------
FGFR3_Hsap MGAPA-------------------CALALCVAVAI--VA---------------------
FGFR2_Hsap MGLTSTWRYGRGPGIGTVTMVSWGRFICLVVVTMATLSL---------------------
FGFR1_Hsap MWSWK-------------------CLLFWAVLVTATLCT---------------------
htl_Dmel MAAAWSWRAS----HSTITMTSG-S-LVVLFLLLSIW-----------------------
btl_Dmel MAKVPIT-------------------LVMIIAIVSAAADLGCDYGHHRCYIDVTVENSPR
FGFR4_Mmus MWLL----------------------LALLSIFQGT------------------------
FGFR3_Mmus MVVPA-------------------CVLVFCVAVVA-------------------------
FGFR2_Mmus MGLPSTWRYGRGPGIGTVTMVSWGRFICLVLVTMATLSL---------------------
FGFR1_Mmus MWGWK-------------------CLLFWAVLVTATLCT---------------------
egl-15_Cele MSYFL-------------------AS-CLGVGLLSTV-----------------------
FGFR_Spur MPEC---------------------TYVQFEMVSASLFD---------------------
*
FGFR4_Hsap --------------GPPV------------------------------------------
FGFR3_Hsap --------------GASS------------------------------------------
FGFR2_Hsap --------------ARPS------------------------------------------
FGFR1_Hsap --------------ARPS------------------------------------------
htl_Dmel ---------------QP-------------------------------------------
btl_Dmel QRHLLSDMDITLQCVRPMAKWFYEDKFQLRATLLRLERAQSGNSGNYGCLDSQNRWYNIS
FGFR4_Mmus ----------------PA------------------------------------------
FGFR3_Mmus --------------GATS------------------------------------------
FGFR2_Mmus --------------ARPS------------------------------------------
FGFR1_Mmus --------------ARPA------------------------------------------
egl-15_Cele -----------------S------------------------------------------
FGFR_Spur --------------LPPP------------------------------------------
FGFR4_Hsap -------------LS---------------------------------------------
FGFR3_Hsap -------------ES---------------------------------------------
FGFR2_Hsap -------------FS---------------------------------------------
FGFR1_Hsap -------------PT---------------------------------------------
htl_Dmel ------------------------------------------------------------
btl_Dmel LVVGHKEPVGNDIAS---------------------------------------------
FGFR4_Mmus -------------LS---------------------------------------------
FGFR3_Mmus -------------EP---------------------------------------------
FGFR2_Mmus -------------FS---------------------------------------------
FGFR1_Mmus -------------PT---------------------------------------------
egl-15_Cele -------------CS---------------------------------------------
FGFR_Spur -------------PPPPFILYEICMRYCACLPDQCMLIVNDACPITMEIFHVGGRPGRPV
FGFR4_Hsap ---LEASEEVELEPCLAPSLE---------------------------------------
FGFR3_Hsap ---LGTEQRVVGRAAEVPGP----------------------------------------
FGFR2_Hsap ---L--VEDTTLEPEEPPTKY---------------------------------------
FGFR1_Hsap ---L--PEQ------AQPWG----------------------------------------
htl_Dmel -----------A-----------VQ-----------------------------------
btl_Dmel ---FVKLEDAPALPESDLFFQPLNESRSLKLLQPLPKTVQRTAGGLFQLNCSPMDPDAKG
FGFR4_Mmus ---LEASEEMEQEPCLAPILE---------------------------------------
FGFR3_Mmus ---PGPEQRVVRRAAEVPGP----------------------------------------
FGFR2_Mmus ---L--VEDTTLEPEEPPTKY---------------------------------------
FGFR1_Mmus ---L--PEQ------AQPWG----------------------------------------
egl-15_Cele ---LQGLT--SHYRENIPRF----------------------------------------
FGFR_Spur HLVLIQAVSFNINPSLPPTLR---------------------------------------
FGFR4_Hsap ------------------------------------------------------------
FGFR3_Hsap ------------------------------------------------------------
FGFR2_Hsap ------------------------------------------------------------
FGFR1_Hsap ------------------------------------------------------------
htl_Dmel -----------V-EG-RRQM----------------------------------------
btl_Dmel VNISWLHNDTQILGGRGRIKLKRWSLTVGQLQPEDAGSYHCELCVEQDCQRSNPTQLEVI
FGFR4_Mmus ------------------------------------------------------------
FGFR3_Mmus ------------------------------------------------------------
FGFR2_Mmus ------------------------------------------------------------
FGFR1_Mmus ------------------------------------------------------------
egl-15_Cele ------------------------------------------------------------
FGFR_Spur ------------------------------------------------------------
FGFR4_Hsap -----------QQEQELTVALGQPVRLCCGRAE----RGGHWYKEGSRLAPAG-------
FGFR3_Hsap ---------EPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSE-------
FGFR2_Hsap ---------QISQPEVYVAAPGESLEVRCLLKDA---AVISWTKDGVHLGPNN-------
FGFR1_Hsap ---------APVEVESFLVHPGDLLQLRCRLRDD--VQSINWLRDGVQLAESN-------
htl_Dmel ------------------------ANSQ------------EMIKDHLGAR----------
btl_Dmel SRKHTVPMLKPGYPRNTSIALGDNVSIECLLEDSALEPKITWLHKGNADNIDD---LLQR
FGFR4_Mmus -----------QQEQVLTVALGQPVRLCCGRTE----RGRHWYKEGSRLASAG-------
FGFR3_Mmus ---------EPSQQEQVAFGSGDTVELSCHPPGGAPTGPTVWAKDGTGLVASH-------
FGFR2_Mmus ---------QISQPEAYVVAPGESLELQCMLKDA---AVISWTKDGVHLGPNN-------
FGFR1_Mmus ---------VPVEVESLLVHPGDLLQLRCRLRDD--VQSINWLRDGVQLVESN-------
egl-15_Cele ---------KHVANERYEVFLGDEIKFDCQTAASKISAFVEWYRNDKLLKNDQIDKD---
FGFR_Spur ----------RNFKGLVEKSLGFEHKIPCPVKAD-PRPYTRWLKNGTDLTPND-PDD---
:.
FGFR4_Hsap ----------RVRG-----WRGRLEIASFLPEDAGRYLCLARG-SMIV------------
FGFR3_Hsap ----------RVLV-----GPQRLQVLNASHEDSGAYSCRQRL-TQRV------------
FGFR2_Hsap ----------RTVL-----IGEYLQIKGATPRDSGLYACTASRTVDSE------------
FGFR1_Hsap ----------RTRI-----TGEEVEVQDSVPADSGLYACVTSSPSGSD------------
htl_Dmel -----------------------------------------------------------S
btl_Dmel LREQSQLPVDVTRLITRMDEPQVLRLGNVLMEDGGWYICIAENQVGRTVAASYVDLYSPS
FGFR4_Mmus ----------RVRG-----WRGRLEIASFLPEDAGRYLCLARG-SMTV------------
FGFR3_Mmus ----------RILV-----GPQRLQVLNASHEDAGVYSCQHRL-TRRV------------
FGFR2_Mmus ----------RTVL-----IGEYLQIKGATPRDSGLYACTAARTVDSE------------
FGFR1_Mmus ----------RTRI-----TGEEVEVRDSIPADSGLYACVTSSPSGSD------------
egl-15_Cele ----------KIRKD---NNRMMLHLKNIDVSDQGLWSCRVHNAYGQI------------
FGFR_Spur ----------NVSF-----TKTSIVFKRLRFSDAGLYTCVASNFFGQPI-----------
FGFR4_Hsap ---L--QNLTLITGDS--------------------------------------------
FGFR3_Hsap ---L--CHFSVRVTDA--------------------------------------------
FGFR2_Hsap ---T--WYFMVNVTDA--------------------------------------------
FGFR1_Hsap ---T--TYFSVNVSDA--------------------------------------------
htl_Dmel QNKT--PAITNNANQS--------------------------------------------
btl_Dmel DTTTVRTTTTTTVASP--------------------------------------------
FGFR4_Mmus ---V--HNLTLLMDDS--------------------------------------------
FGFR3_Mmus ---L--CHFSVRVTDA--------------------------------------------
FGFR2_Mmus ---T--WYFMVNVTDA--------------------------------------------
FGFR1_Mmus ---T--TYFSVNVSDA--------------------------------------------
egl-15_Cele ---S--RNFTVEVIDFCDYFLFPDIHHLNIPMECVCLWKYNKEAKRSDVNYAAVTGEVCS
FGFR_Spur ---H--VNFTLIVVDT--------------------------------------------
.
FGFR4_Hsap ------------------------------------------------------------
FGFR3_Hsap ------------------------------------------------------------
FGFR2_Hsap ------------------------------------------------------------
FGFR1_Hsap ------------------------------------------------------------
htl_Dmel ------------------------------------------------------------
btl_Dmel ---------------------------------------------------------I--
FGFR4_Mmus ------------------------------------------------------------
FGFR3_Mmus ------------------------------------------------------------
FGFR2_Mmus ------------------------------------------------------------
FGFR1_Mmus ------------------------------------------------------------
egl-15_Cele KYASRMINRARKPLPMIPCFGDHCKEFDTTPVSDFGLPGKPEDDPLVKRVVLKKDDVIVP
FGFR_Spur ------------------------------------------------------------
FGFR4_Hsap -------L-------TSSNDDEDPKSH-R--DP----SNR-HSY-----------PQQAP
FGFR3_Hsap -------P-------SSG-DDEDGEDE--AEDT----GV----------------DTGAP
FGFR2_Hsap -------I-------SSG-DDEDDTDG--AEDF----VSE-NSN-----------NKRAP
FGFR1_Hsap -------L-------PSSEDDDDDDDS-SSEEK----ETD-NTK--------PNRMPVAP
htl_Dmel --------------STSSADLDDG-AA-DDDDN----KADLPVN-----------VSSKP
btl_Dmel -------P------TASTGEDNDD-DV---ENP----AAE-ASG-----------GVGPP
FGFR4_Mmus -------L-------TSISNDEDPKTL-S--SS----SSG-HVY-----------PQQAP
FGFR3_Mmus -------P-------SSG-DDEDGEDV--AED------------------------TGAP
FGFR2_Mmus -------I-------SSG-DDEDDTDS--SEDV----VSE-NRS-----------NQRAP
FGFR1_Mmus -------L-------PSSEDDDDDDDS-SSEEK----ETD-NTK--------PNRRPVAP
egl-15_Cele VHDSEESPSESRTEFINADEKENKEDE--EEDY----SVSQPVAPDAGLTELNITAEEPP
FGFR_Spur -------H-------SESYAESSVLESFSSLELETGPYNETEEE-----------ETHFP
. .. . *
FGFR4_Hsap YWTHPQRM--EKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHG-ENRIGGIRLRH
FGFR3_Hsap YWTRPERM--DKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRG-EHRIGGIKLRH
FGFR2_Hsap YWTNTEKM--EKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQ-EHRIGGYKVRN
FGFR1_Hsap YWTSPEKM--EKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKP-DHRIGGYKVRY
htl_Dmel YWRNPKKM---SFLQTRPSGSLLTLNCHALGNPEPNITWYRNGTVDW----TRGYGSLKR
btl_Dmel VFRK--EL---KRLQHSLSGNTVNLACPVYGKA--NITWTKDKKPLN----RELGVYV-Q
FGFR4_Mmus YWTHPQRM--EKKLHAVPAGNTVKFRCPAAGNPMPTIHWLKDGQAFHG-ENRIGGIRLRH
FGFR3_Mmus YWTRPERM--DKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGKEFRG-EHRIGGIKLRH
FGFR2_Mmus YWTNTEKM--EKRLHAVPAANTVKFRCPAGGNPTPTMRWLKNGKEFKQ-EHRIGGYKVRN
FGFR1_Mmus YWTSPEKM--EKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKP-DHRIGGYKVRY
egl-15_Cele YFKSNDNIVLFNETHALPAGRTLKLNCRAKGYPEPQIIWYKNGKMLKKSSARSGGYEFKF
FGFR_Spur RFTDTERM--EPE-KPLPSNTKVRLECGARGTPTPNITWIKDGVQKWK-INVIRPTRVEE
: .: : : : * * . : * :: .
FGFR4_Hsap QHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVG
FGFR3_Hsap QQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLG
FGFR2_Hsap QHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVG
FGFR1_Hsap ATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALG
htl_Dmel NRWTLTMEDLVPGDCGNYTCKVCNSLGCIRHDTQVIVSDRVNHKPILMTG-PLNLTLVVN
btl_Dmel KNWTLRFVEATSEDSGLYNCKVCNAWGCIQFDFSVQINDRTRSAPIIVV--PQNQTVKVN
FGFR4_Mmus QHWSLVMESVVPSDRGTYTCLVENSLGSIRYSYLLDVLERSPHRPILQAGLPANTTAVVG
FGFR3_Mmus QQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAILG
FGFR2_Mmus QHWSLIMESVVPSDKGNYTCLVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVG
FGFR1_Mmus ATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALG
egl-15_Cele NRWSLEVEDAVVADSGEFHCEALNKVGSAKKYFHVIIVNRMRRPPIIVPNILANQSVNIN
FGFR_Spur KGFVLIIRRAIVRDTGKYTCIVSNQYGTIEHTYDVKIRERLPVKPIMSP--MKNVTATVG
: : . * * : * . * * . : : :* **: * : :.
FGFR4_Hsap SDVELLCKVYSDAQPHIQWLKHIVINGSSFGA-DGFPYVQVLKTADI-------------
FGFR3_Hsap SDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP-DGTPYVTVLKSWIS-------------
FGFR2_Hsap GDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGP-DGLPYLKVLKHSGI-------------
FGFR1_Hsap SNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGP-DNLPYVQILKTAGV-------------
htl_Dmel STGSMHCKYLSDLTSKKAWIFV-PCHGMTNCS----------NNRSI-------------
btl_Dmel GSLVMKCTVYSDLHPTVSWKRVVLKNASLDGL----KSVEIQNLNFT-------------
FGFR4_Mmus SDVELLCKVYSDAQPHIQWLKHVVINGSSFGA-DGFPYVQVLKTTDI-------------
FGFR3_Mmus SDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP-DGTPYVTVLKTAGA-------------
FGFR2_Mmus GDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGP-DGLPYLKVLKAAGV-------------
FGFR1_Mmus SNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGP-DNLPYVQILKTAGV-------------
egl-15_Cele DTATFHCKVVSDLLPHIIWVRINKINGSYSYY-NNSAEEYMFNYTEM-------------
FGFR_Spur SNTSFVCRVVSDLTPHFAWMRFNGTNNTKQRLTDIDDHISILQQRWVEEPMLTCDEFLDV
. : * ** . * : :
FGFR4_Hsap --------------------NSS---------EVEVLYLRNVSAEDAGEYTCLAGNSIGL
FGFR3_Hsap --------------------ESVE-------AD-VRLRLANVSERDGGEYLCRATNFIGV
FGFR2_Hsap --------------------NSS---------NAEVLALFNVTEADAGEYICKVSNYIGQ
FGFR1_Hsap --------------------NTTD-------KEMEVLHLRNVSFEDAGEYTCLAGNSIGL
htl_Dmel --------------------IAE---------DKDQLDFVNVRMEQEGWYTCVESNSLGQ
btl_Dmel --------------------VTN---------DSVVLTLRNVTFDQEGWYTCLASSGLGR
FGFR4_Mmus --------------------NSS---------EVEVLYLRNVSAEDAGEYTCLAGNSIGL
FGFR3_Mmus --------------------NTTD-------KELEVLSLHNVTFEDAGEYTCLAGNSIGF
FGFR2_Mmus --------------------NTTD-------KEIEVLYIRNVTFEDAGEYTCLAGNSIGI
FGFR1_Mmus --------------------NTTD-------KEMEVLHLRNVSFEDAGEYTCLAGNSIGL
egl-15_Cele --------------------DTFDKAHVHHVGDESTLTIFNVSLDDQGIYACLSGNSLGM
FGFR_Spur FYQNQSKRMLECLHLIQLETQGGM-------EEANQLKLYNVQYEDEGPYLCVAGNFYGM
: * : ** : * * * . *
FGFR4_Hsap SYQSAWLTVLPEEDP-------TWTAAAPEA----------RYTD--IILYASGSLALAV
FGFR3_Hsap AEKAFWLSVHGPRAAEE----ELVEADEAGS----------VYAG--ILSYGVGFFLFIL
FGFR2_Hsap ANQSAWLTVLPKQQAPG----REKEI-TASP----------DYLE--IAIYCIGVFLIAC
FGFR1_Hsap SHHSAWLTVLEALEE-------RPAV-MTSP----------LYLE--IIIYCTGAFLISC
htl_Dmel SNSTAYLRVVRSLHVLE-----AGVA--SGS----------LHSTSFVYIFVFGGLIFIF
btl_Dmel SNSSVYLRVVSPLPPLE-----IYALLHAHP----------LGFT-LAAITIV--ALFLL
FGFR4_Mmus SYQSAWLTVLPEEDL-------TWTTATPEA----------RYTD--IILYVSGSLVLLV
FGFR3_Mmus SHHSAWLVVLPAE---E----ELMETDEAGS----------VYAG--VLSYGVVFFLFIL
FGFR2_Mmus SFHSAWLTVLPAPVR-------EKEI-TASP----------DYLE--IAIYCIGVFLIAC
FGFR1_Mmus SHHSAWLTVLEALEE-------RPAV-MTSP----------LYLE--IIIYCTGAFLISC
egl-15_Cele SMANATLTVNEFMAIHLLTGDEPKIDRWTTS----------DY--IF--TTILLFLLLAA
FGFR_Spur SWEGAYLDVVEPTTQ-------APVRTNPPAVYIPNNMQPTSKTQ--LIIFSVVGFVVVL
: * * . . .
FGFR4_Hsap LLLLAGLYRGQALHGRHP--RPPAT-VQKLS-RFPL-ARQFS--LESGSSGKSS-S----
FGFR3_Hsap VVAAVTLCRLRSPPKKGL---GSPT-VHKIS-RFPL-KRQVS--LESNASMSSN-T----
FGFR2_Hsap MVVTVILCRMKNTTKKPDF-SSQPA-VHKLTKRIPL-RRQVTVSAESSSSMNSN-T----
FGFR1_Hsap MVGSVIVYKMKSGTKKSDF-HSQMA-VHKLAKSIPL-RRQVTVSADSSASMNSG-V----
htl_Dmel MTTLFVFYAIRKMKHEKVLKQRIET-VHQWTKKVII-FKPEG-GGDSSGSMDTMIM----
btl_Dmel G-SAFITFMLRRLRREKLLKLRIET-VHQWTKKVII-YRPGGEEGSGCSSGDLQ-M----
FGFR4_Mmus LLLLAGVYHRQVIRGHYS--RQPVT-IQKLS-RFPL-ARQFS--LESRSSGKSS-L----
FGFR3_Mmus VVAAVILCRLRSPPKKGL---GSPT-VHKVS-RFPL-KRQVS--LESNSSMNSN-T----
FGFR2_Mmus MVVTVIFCRMKTTTKKPDF-SSQPA-VHKLTKRIPL-RRQVTVSAESSSSMNSN-T----
FGFR1_Mmus MLGSVIIYKMKSGTKKSDF-HSQMA-VHKLAKSIPL-RRQVTVSADSSASMNSG-V----
egl-15_Cele TLFGILFMVCKQTLHKKGFMDDTVGLVARKK-RVVVSKRPMNE--DNENSDDEP-SPYQI
FGFR_Spur ILVTCIAILCKQTQVRHRRPSDKP----DISGPKHL-YRQTS--VDSTQS---I-A----
: . : : .. *
FGFR4_Hsap -----SLV-----RG--VRL--SS--S-GPALLAGLVSLDLPLDPLWEFPRDRLVLGKPL
FGFR3_Hsap -----PLV-----RI--ARL--SS--G-EGPTLANVSELELPADPKWELSRARLTLGKPL
FGFR2_Hsap -----PLV-----RIT-TRL--SS--TADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPL
FGFR1_Hsap -----LLV-----RP--SRL--SS--S-GTPMLAGVSEYELPEDPRWELPRDRLVLGKPL
htl_Dmel -----PVV-----RIQKQRTTV--LQNG--NEPAPFNEYEFPLDSNWELPRSHLVLGATL
btl_Dmel -----PVI-----RIEKQRTTVSTTGTGGTDPAQGFNEYEFPLDSNWEIPRQQLSLGSIL
FGFR4_Mmus -----SLV-----RG--VRL--SS--S-GPPLLTGLVNLDLPLDPLWEFPRDRLVLGKPL
FGFR3_Mmus -----PLV-----RI--ARL--SS--G-EGPVLANVSELELPADPKWELSRTRLTLGKPL
FGFR2_Mmus -----PLV-----RIT-TRL--SS--TADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPL
FGFR1_Mmus -----LLV-----RP--SRL--SS--S-GTPMLAGVSEYELPEDPRWELPRDRLVLGKPL
egl-15_Cele QIIETPITKKEAARKQRKRM--NS---E----NTVLSEYEVDSDPVWEVERSKLSLVHML
FGFR_Spur -----PLF-----GGR-NRL--TS--S-----LTVISEYDIPLDPEWEFPRDRLTVGKTI
: * . . :. *. **. * :* : :
FGFR4_Hsap GEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNI
FGFR3_Hsap GEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNI
FGFR2_Hsap GEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNI
FGFR1_Hsap GEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNI
htl_Dmel GEGAFGRVVMAEV---------NNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINI
btl_Dmel GEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINI
FGFR4_Mmus GEGCFGQVVRAEAFGMDPSRPDQTSTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNI
FGFR3_Mmus GEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNI
FGFR2_Mmus GEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNI
FGFR1_Mmus GEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNI
egl-15_Cele GEGAFGEVWKATY----KETENNEIAVAVKKLKMSAHEKELIDLVSEMETFKVIGEHENV
FGFR_Spur GEGAFGKVVIGEAVGIVC--QEKTSTVAVKMLKANAMDREFSDLISELAMMKMIGKNPNI
***.**.* . **** :* : :: .*: *: :*:**.: *:
FGFR4_Hsap INLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDG-----------------
FGFR3_Hsap INLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDT-----------------
FGFR2_Hsap INLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDI-----------------
FGFR1_Hsap INLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNP-----------------
htl_Dmel INLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSS--------------QP
btl_Dmel INLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRSDSDGYL-----------DD
FGFR4_Mmus INLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDG-----------------
FGFR3_Mmus INLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGMDYSFDA-----------------
FGFR2_Mmus INLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDI-----------------
FGFR1_Mmus INLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNP-----------------
egl-15_Cele LRLIGCCTGAGPLYVVVELCKHGNLRDFLRAHRPKEEKAKKSSQELTDYLEPRKASDKDD
FGFR_Spur INLLGCCTQEGPPYVIVEFAHHGNLRDFLRSRRPPE-EYEKSI-----------------
:.*:* *: ** :*:** . :***:::* .** . .
FGFR4_Hsap -PRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLAR
FGFR3_Hsap -CKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLAR
FGFR2_Hsap -NRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLAR
FGFR1_Hsap -SHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLAR
htl_Dmel PPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLAR
btl_Dmel KPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLAR
FGFR4_Mmus -PRSSEGPLSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLAR
FGFR3_Mmus -CRLPEEQLTCKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLAR
FGFR2_Mmus -NRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLAR
FGFR1_Mmus -SHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLAR
egl-15_Cele IELI--PNLTQRHLVQFAWQVAQGMNFLASKKIIHRDLAARNVLVGDGHVLKISDFGLSR
FGFR_Spur -LLTTSQTLTNKDLMSMAYQVARGMDFLASKKCIHRDLAARNVLVTEDFEMKICDFGLAR
: * . : *:*:**::* *:: ************ :. :**.****:*
FGFR4_Hsap GVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGI-P
FGFR3_Hsap DVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGI-P
FGFR2_Hsap DINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI-P
FGFR1_Hsap DIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV-P
htl_Dmel DIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMS
btl_Dmel DIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILS
FGFR4_Mmus GVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGI-P
FGFR3_Mmus DVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGI-P
FGFR2_Mmus DINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI-P
FGFR1_Mmus DIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV-P
egl-15_Cele DVHCNDYYRKRGNGRLPIKWMALEALDSNVYTVESDVWSYGVLLWEIMTLGGTPYPTI-A
FGFR_Spur DIHYIDFYRKTTDGRLPVKWMAPEALFDRMFTTQSDVWSFGILLWEIMTLGGTPYPSV-P
.:: ::*:* :****:**** *:* .. : :*****:*:*:***:* * *** : .
FGFR4_Hsap VEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLL-AV---
FGFR3_Hsap VEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTS---
FGFR2_Hsap VEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT---
FGFR1_Hsap VEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTS---
htl_Dmel AEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQ--T---
btl_Dmel AEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDGILQQASSNP
FGFR4_Mmus VEELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRPTFKQLVEALDKVLL-AV---
FGFR3_Mmus VEELFKLLKEGHRMDKPASCTHDLYMIMRECWHAVPSQRPTFKQLVEDLDRILTVTS---
FGFR2_Mmus VEELFKLLKEGHRMDKPTNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT---
FGFR1_Mmus VEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTS---
egl-15_Cele MPELYANLKEGYRMEPPHLCPQEVYHLMCSCWREKLEERPSFKTIVDYLDWMLTMTN---
FGFR_Spur VEQMFDYLRSGKRLEKPQNTSLEIYHILCECWRTSPGQRPTFCELVEDLDRIISVSS---
::: * * *:: * . ::* :: .**: **.* :*: :* ::
FGFR4_Hsap SEEYLDLRLTFGPYSPSGGDA------------------------------SS-TCSS-S
FGFR3_Hsap TDEYLDLSAPFEQYSPGGQDT------------------------------PSS-SSSGD
FGFR2_Hsap NEEYLDLSQPLEQYSPSYPDT------------------------------RSS-CSSGD
FGFR1_Hsap NQEYLDLSMPLDQYSPSFPDT------------------------------RSSTCSSGE
htl_Dmel KEDYLDVDIANLDTPPSTSDE------------------------------EEDE-T---
btl_Dmel NDAYLDLSMPMLETPPSSGDE------------------------------DDGS-D--T
FGFR4_Mmus SEEYLDLRLTFGPFSPSNGDA------------------------------SS-TCSS-S
FGFR3_Mmus TDEYLDLSVPFEQYSPGGQDT------------------------------PSS-SSSGD
FGFR2_Mmus NEEYLDLTQPLEQYSPSYPDT------------------------------RSS-CSSGD
FGFR1_Mmus NQEYLDLSIPLDQYSPSFPDT------------------------------RSSTCSSGE
egl-15_Cele --ETIEGSQEFNDQFFSERSTASGPVSPMESFQKKRKHRPLSAPVNLPSEPQHTICDD-Y
FGFR_Spur NQDYLDLEAVGDAPVKTFQES------------------------------ERM------
:: .
FGFR4_Hsap DSVFSHDPLPLGSS--------------------SF----PFGSGVQT
FGFR3_Hsap DSVFAHDLLPPAP---------------------------PSSGGSRT
FGFR2_Hsap DSVFSPDPMPYEPC-L-----------------PQYP---HINGSVKT
FGFR1_Hsap DSVFSHEPLPEEPC-L-----------------PRHPAQLANGGLKRR
htl_Dmel DN---------------------------------------LQKWCNY
btl_Dmel ETFRETS-----PL--------------------R-----YQYTYKFN
FGFR4_Mmus DSVFSHDPLPLEPS--------------------PF----PFSDSQTT
FGFR3_Mmus DSVFTHDLLPPGP---------------------------PSNGGPRT
FGFR2_Mmus DSVFSPDPMPYEPC-L-----------------PQYP---HINGSVKT
FGFR1_Mmus DSVFSHEPLPEEPC-L-----------------PRHPTQLANSGLKRR
egl-15_Cele ESNFSVEP-PNDPNHLYCNDNMLKNHIITPETSQRIPSNNNSMSKPEF
FGFR_Spur --AFMGFRAPLSPQ-V------------Y----YKVPQT-RDCCPYAN