Protein (view, download) , Domain (view, download)
FGFR4_Hsap      MRLL----------------------LALLGVLLSV--P---------------------
FGFR3_Hsap      MGAPA-------------------CALALCVAVAI--VA---------------------
FGFR2_Hsap      MGLTSTWRYGRGPGIGTVTMVSWGRFICLVVVTMATLSL---------------------
FGFR1_Hsap      MWSWK-------------------CLLFWAVLVTATLCT---------------------
htl_Dmel        MAAAWSWRAS----HSTITMTSG-S-LVVLFLLLSIW-----------------------
btl_Dmel        MAKVPIT-------------------LVMIIAIVSAAADLGCDYGHHRCYIDVTVENSPR
FGFR4_Mmus      MWLL----------------------LALLSIFQGT------------------------
FGFR3_Mmus      MVVPA-------------------CVLVFCVAVVA-------------------------
FGFR2_Mmus      MGLPSTWRYGRGPGIGTVTMVSWGRFICLVLVTMATLSL---------------------
FGFR1_Mmus      MWGWK-------------------CLLFWAVLVTATLCT---------------------
egl-15_Cele     MSYFL-------------------AS-CLGVGLLSTV-----------------------
FGFR_Spur       MPEC---------------------TYVQFEMVSASLFD---------------------
                *

FGFR4_Hsap      --------------GPPV------------------------------------------
FGFR3_Hsap      --------------GASS------------------------------------------
FGFR2_Hsap      --------------ARPS------------------------------------------
FGFR1_Hsap      --------------ARPS------------------------------------------
htl_Dmel        ---------------QP-------------------------------------------
btl_Dmel        QRHLLSDMDITLQCVRPMAKWFYEDKFQLRATLLRLERAQSGNSGNYGCLDSQNRWYNIS
FGFR4_Mmus      ----------------PA------------------------------------------
FGFR3_Mmus      --------------GATS------------------------------------------
FGFR2_Mmus      --------------ARPS------------------------------------------
FGFR1_Mmus      --------------ARPA------------------------------------------
egl-15_Cele     -----------------S------------------------------------------
FGFR_Spur       --------------LPPP------------------------------------------


FGFR4_Hsap      -------------LS---------------------------------------------
FGFR3_Hsap      -------------ES---------------------------------------------
FGFR2_Hsap      -------------FS---------------------------------------------
FGFR1_Hsap      -------------PT---------------------------------------------
htl_Dmel        ------------------------------------------------------------
btl_Dmel        LVVGHKEPVGNDIAS---------------------------------------------
FGFR4_Mmus      -------------LS---------------------------------------------
FGFR3_Mmus      -------------EP---------------------------------------------
FGFR2_Mmus      -------------FS---------------------------------------------
FGFR1_Mmus      -------------PT---------------------------------------------
egl-15_Cele     -------------CS---------------------------------------------
FGFR_Spur       -------------PPPPFILYEICMRYCACLPDQCMLIVNDACPITMEIFHVGGRPGRPV


FGFR4_Hsap      ---LEASEEVELEPCLAPSLE---------------------------------------
FGFR3_Hsap      ---LGTEQRVVGRAAEVPGP----------------------------------------
FGFR2_Hsap      ---L--VEDTTLEPEEPPTKY---------------------------------------
FGFR1_Hsap      ---L--PEQ------AQPWG----------------------------------------
htl_Dmel        -----------A-----------VQ-----------------------------------
btl_Dmel        ---FVKLEDAPALPESDLFFQPLNESRSLKLLQPLPKTVQRTAGGLFQLNCSPMDPDAKG
FGFR4_Mmus      ---LEASEEMEQEPCLAPILE---------------------------------------
FGFR3_Mmus      ---PGPEQRVVRRAAEVPGP----------------------------------------
FGFR2_Mmus      ---L--VEDTTLEPEEPPTKY---------------------------------------
FGFR1_Mmus      ---L--PEQ------AQPWG----------------------------------------
egl-15_Cele     ---LQGLT--SHYRENIPRF----------------------------------------
FGFR_Spur       HLVLIQAVSFNINPSLPPTLR---------------------------------------


FGFR4_Hsap      ------------------------------------------------------------
FGFR3_Hsap      ------------------------------------------------------------
FGFR2_Hsap      ------------------------------------------------------------
FGFR1_Hsap      ------------------------------------------------------------
htl_Dmel        -----------V-EG-RRQM----------------------------------------
btl_Dmel        VNISWLHNDTQILGGRGRIKLKRWSLTVGQLQPEDAGSYHCELCVEQDCQRSNPTQLEVI
FGFR4_Mmus      ------------------------------------------------------------
FGFR3_Mmus      ------------------------------------------------------------
FGFR2_Mmus      ------------------------------------------------------------
FGFR1_Mmus      ------------------------------------------------------------
egl-15_Cele     ------------------------------------------------------------
FGFR_Spur       ------------------------------------------------------------


FGFR4_Hsap      -----------QQEQELTVALGQPVRLCCGRAE----RGGHWYKEGSRLAPAG-------
FGFR3_Hsap      ---------EPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSE-------
FGFR2_Hsap      ---------QISQPEVYVAAPGESLEVRCLLKDA---AVISWTKDGVHLGPNN-------
FGFR1_Hsap      ---------APVEVESFLVHPGDLLQLRCRLRDD--VQSINWLRDGVQLAESN-------
htl_Dmel        ------------------------ANSQ------------EMIKDHLGAR----------
btl_Dmel        SRKHTVPMLKPGYPRNTSIALGDNVSIECLLEDSALEPKITWLHKGNADNIDD---LLQR
FGFR4_Mmus      -----------QQEQVLTVALGQPVRLCCGRTE----RGRHWYKEGSRLASAG-------
FGFR3_Mmus      ---------EPSQQEQVAFGSGDTVELSCHPPGGAPTGPTVWAKDGTGLVASH-------
FGFR2_Mmus      ---------QISQPEAYVVAPGESLELQCMLKDA---AVISWTKDGVHLGPNN-------
FGFR1_Mmus      ---------VPVEVESLLVHPGDLLQLRCRLRDD--VQSINWLRDGVQLVESN-------
egl-15_Cele     ---------KHVANERYEVFLGDEIKFDCQTAASKISAFVEWYRNDKLLKNDQIDKD---
FGFR_Spur       ----------RNFKGLVEKSLGFEHKIPCPVKAD-PRPYTRWLKNGTDLTPND-PDD---
                                                           :.

FGFR4_Hsap      ----------RVRG-----WRGRLEIASFLPEDAGRYLCLARG-SMIV------------
FGFR3_Hsap      ----------RVLV-----GPQRLQVLNASHEDSGAYSCRQRL-TQRV------------
FGFR2_Hsap      ----------RTVL-----IGEYLQIKGATPRDSGLYACTASRTVDSE------------
FGFR1_Hsap      ----------RTRI-----TGEEVEVQDSVPADSGLYACVTSSPSGSD------------
htl_Dmel        -----------------------------------------------------------S
btl_Dmel        LREQSQLPVDVTRLITRMDEPQVLRLGNVLMEDGGWYICIAENQVGRTVAASYVDLYSPS
FGFR4_Mmus      ----------RVRG-----WRGRLEIASFLPEDAGRYLCLARG-SMTV------------
FGFR3_Mmus      ----------RILV-----GPQRLQVLNASHEDAGVYSCQHRL-TRRV------------
FGFR2_Mmus      ----------RTVL-----IGEYLQIKGATPRDSGLYACTAARTVDSE------------
FGFR1_Mmus      ----------RTRI-----TGEEVEVRDSIPADSGLYACVTSSPSGSD------------
egl-15_Cele     ----------KIRKD---NNRMMLHLKNIDVSDQGLWSCRVHNAYGQI------------
FGFR_Spur       ----------NVSF-----TKTSIVFKRLRFSDAGLYTCVASNFFGQPI-----------


FGFR4_Hsap      ---L--QNLTLITGDS--------------------------------------------
FGFR3_Hsap      ---L--CHFSVRVTDA--------------------------------------------
FGFR2_Hsap      ---T--WYFMVNVTDA--------------------------------------------
FGFR1_Hsap      ---T--TYFSVNVSDA--------------------------------------------
htl_Dmel        QNKT--PAITNNANQS--------------------------------------------
btl_Dmel        DTTTVRTTTTTTVASP--------------------------------------------
FGFR4_Mmus      ---V--HNLTLLMDDS--------------------------------------------
FGFR3_Mmus      ---L--CHFSVRVTDA--------------------------------------------
FGFR2_Mmus      ---T--WYFMVNVTDA--------------------------------------------
FGFR1_Mmus      ---T--TYFSVNVSDA--------------------------------------------
egl-15_Cele     ---S--RNFTVEVIDFCDYFLFPDIHHLNIPMECVCLWKYNKEAKRSDVNYAAVTGEVCS
FGFR_Spur       ---H--VNFTLIVVDT--------------------------------------------
                              .

FGFR4_Hsap      ------------------------------------------------------------
FGFR3_Hsap      ------------------------------------------------------------
FGFR2_Hsap      ------------------------------------------------------------
FGFR1_Hsap      ------------------------------------------------------------
htl_Dmel        ------------------------------------------------------------
btl_Dmel        ---------------------------------------------------------I--
FGFR4_Mmus      ------------------------------------------------------------
FGFR3_Mmus      ------------------------------------------------------------
FGFR2_Mmus      ------------------------------------------------------------
FGFR1_Mmus      ------------------------------------------------------------
egl-15_Cele     KYASRMINRARKPLPMIPCFGDHCKEFDTTPVSDFGLPGKPEDDPLVKRVVLKKDDVIVP
FGFR_Spur       ------------------------------------------------------------


FGFR4_Hsap      -------L-------TSSNDDEDPKSH-R--DP----SNR-HSY-----------PQQAP
FGFR3_Hsap      -------P-------SSG-DDEDGEDE--AEDT----GV----------------DTGAP
FGFR2_Hsap      -------I-------SSG-DDEDDTDG--AEDF----VSE-NSN-----------NKRAP
FGFR1_Hsap      -------L-------PSSEDDDDDDDS-SSEEK----ETD-NTK--------PNRMPVAP
htl_Dmel        --------------STSSADLDDG-AA-DDDDN----KADLPVN-----------VSSKP
btl_Dmel        -------P------TASTGEDNDD-DV---ENP----AAE-ASG-----------GVGPP
FGFR4_Mmus      -------L-------TSISNDEDPKTL-S--SS----SSG-HVY-----------PQQAP
FGFR3_Mmus      -------P-------SSG-DDEDGEDV--AED------------------------TGAP
FGFR2_Mmus      -------I-------SSG-DDEDDTDS--SEDV----VSE-NRS-----------NQRAP
FGFR1_Mmus      -------L-------PSSEDDDDDDDS-SSEEK----ETD-NTK--------PNRRPVAP
egl-15_Cele     VHDSEESPSESRTEFINADEKENKEDE--EEDY----SVSQPVAPDAGLTELNITAEEPP
FGFR_Spur       -------H-------SESYAESSVLESFSSLELETGPYNETEEE-----------ETHFP
                                .    ..        .                           *

FGFR4_Hsap      YWTHPQRM--EKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHG-ENRIGGIRLRH
FGFR3_Hsap      YWTRPERM--DKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRG-EHRIGGIKLRH
FGFR2_Hsap      YWTNTEKM--EKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQ-EHRIGGYKVRN
FGFR1_Hsap      YWTSPEKM--EKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKP-DHRIGGYKVRY
htl_Dmel        YWRNPKKM---SFLQTRPSGSLLTLNCHALGNPEPNITWYRNGTVDW----TRGYGSLKR
btl_Dmel        VFRK--EL---KRLQHSLSGNTVNLACPVYGKA--NITWTKDKKPLN----RELGVYV-Q
FGFR4_Mmus      YWTHPQRM--EKKLHAVPAGNTVKFRCPAAGNPMPTIHWLKDGQAFHG-ENRIGGIRLRH
FGFR3_Mmus      YWTRPERM--DKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGKEFRG-EHRIGGIKLRH
FGFR2_Mmus      YWTNTEKM--EKRLHAVPAANTVKFRCPAGGNPTPTMRWLKNGKEFKQ-EHRIGGYKVRN
FGFR1_Mmus      YWTSPEKM--EKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKP-DHRIGGYKVRY
egl-15_Cele     YFKSNDNIVLFNETHALPAGRTLKLNCRAKGYPEPQIIWYKNGKMLKKSSARSGGYEFKF
FGFR_Spur       RFTDTERM--EPE-KPLPSNTKVRLECGARGTPTPNITWIKDGVQKWK-INVIRPTRVEE
                 :    .:          :   : : *   * .   : * ::               .

FGFR4_Hsap      QHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVG
FGFR3_Hsap      QQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLG
FGFR2_Hsap      QHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVG
FGFR1_Hsap      ATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALG
htl_Dmel        NRWTLTMEDLVPGDCGNYTCKVCNSLGCIRHDTQVIVSDRVNHKPILMTG-PLNLTLVVN
btl_Dmel        KNWTLRFVEATSEDSGLYNCKVCNAWGCIQFDFSVQINDRTRSAPIIVV--PQNQTVKVN
FGFR4_Mmus      QHWSLVMESVVPSDRGTYTCLVENSLGSIRYSYLLDVLERSPHRPILQAGLPANTTAVVG
FGFR3_Mmus      QQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAILG
FGFR2_Mmus      QHWSLIMESVVPSDKGNYTCLVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVG
FGFR1_Mmus      ATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALG
egl-15_Cele     NRWSLEVEDAVVADSGEFHCEALNKVGSAKKYFHVIIVNRMRRPPIIVPNILANQSVNIN
FGFR_Spur       KGFVLIIRRAIVRDTGKYTCIVSNQYGTIEHTYDVKIRERLPVKPIMSP--MKNVTATVG
                  : : .      * * : * . *  *  .    : : :*    **:      * :  :.

FGFR4_Hsap      SDVELLCKVYSDAQPHIQWLKHIVINGSSFGA-DGFPYVQVLKTADI-------------
FGFR3_Hsap      SDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP-DGTPYVTVLKSWIS-------------
FGFR2_Hsap      GDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGP-DGLPYLKVLKHSGI-------------
FGFR1_Hsap      SNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGP-DNLPYVQILKTAGV-------------
htl_Dmel        STGSMHCKYLSDLTSKKAWIFV-PCHGMTNCS----------NNRSI-------------
btl_Dmel        GSLVMKCTVYSDLHPTVSWKRVVLKNASLDGL----KSVEIQNLNFT-------------
FGFR4_Mmus      SDVELLCKVYSDAQPHIQWLKHVVINGSSFGA-DGFPYVQVLKTTDI-------------
FGFR3_Mmus      SDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP-DGTPYVTVLKTAGA-------------
FGFR2_Mmus      GDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGP-DGLPYLKVLKAAGV-------------
FGFR1_Mmus      SNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGP-DNLPYVQILKTAGV-------------
egl-15_Cele     DTATFHCKVVSDLLPHIIWVRINKINGSYSYY-NNSAEEYMFNYTEM-------------
FGFR_Spur       SNTSFVCRVVSDLTPHFAWMRFNGTNNTKQRLTDIDDHISILQQRWVEEPMLTCDEFLDV
                .   : *   **  .   *      :                :

FGFR4_Hsap      --------------------NSS---------EVEVLYLRNVSAEDAGEYTCLAGNSIGL
FGFR3_Hsap      --------------------ESVE-------AD-VRLRLANVSERDGGEYLCRATNFIGV
FGFR2_Hsap      --------------------NSS---------NAEVLALFNVTEADAGEYICKVSNYIGQ
FGFR1_Hsap      --------------------NTTD-------KEMEVLHLRNVSFEDAGEYTCLAGNSIGL
htl_Dmel        --------------------IAE---------DKDQLDFVNVRMEQEGWYTCVESNSLGQ
btl_Dmel        --------------------VTN---------DSVVLTLRNVTFDQEGWYTCLASSGLGR
FGFR4_Mmus      --------------------NSS---------EVEVLYLRNVSAEDAGEYTCLAGNSIGL
FGFR3_Mmus      --------------------NTTD-------KELEVLSLHNVTFEDAGEYTCLAGNSIGF
FGFR2_Mmus      --------------------NTTD-------KEIEVLYIRNVTFEDAGEYTCLAGNSIGI
FGFR1_Mmus      --------------------NTTD-------KEMEVLHLRNVSFEDAGEYTCLAGNSIGL
egl-15_Cele     --------------------DTFDKAHVHHVGDESTLTIFNVSLDDQGIYACLSGNSLGM
FGFR_Spur       FYQNQSKRMLECLHLIQLETQGGM-------EEANQLKLYNVQYEDEGPYLCVAGNFYGM
                                                :   * : **   : * * *   .  *

FGFR4_Hsap      SYQSAWLTVLPEEDP-------TWTAAAPEA----------RYTD--IILYASGSLALAV
FGFR3_Hsap      AEKAFWLSVHGPRAAEE----ELVEADEAGS----------VYAG--ILSYGVGFFLFIL
FGFR2_Hsap      ANQSAWLTVLPKQQAPG----REKEI-TASP----------DYLE--IAIYCIGVFLIAC
FGFR1_Hsap      SHHSAWLTVLEALEE-------RPAV-MTSP----------LYLE--IIIYCTGAFLISC
htl_Dmel        SNSTAYLRVVRSLHVLE-----AGVA--SGS----------LHSTSFVYIFVFGGLIFIF
btl_Dmel        SNSSVYLRVVSPLPPLE-----IYALLHAHP----------LGFT-LAAITIV--ALFLL
FGFR4_Mmus      SYQSAWLTVLPEEDL-------TWTTATPEA----------RYTD--IILYVSGSLVLLV
FGFR3_Mmus      SHHSAWLVVLPAE---E----ELMETDEAGS----------VYAG--VLSYGVVFFLFIL
FGFR2_Mmus      SFHSAWLTVLPAPVR-------EKEI-TASP----------DYLE--IAIYCIGVFLIAC
FGFR1_Mmus      SHHSAWLTVLEALEE-------RPAV-MTSP----------LYLE--IIIYCTGAFLISC
egl-15_Cele     SMANATLTVNEFMAIHLLTGDEPKIDRWTTS----------DY--IF--TTILLFLLLAA
FGFR_Spur       SWEGAYLDVVEPTTQ-------APVRTNPPAVYIPNNMQPTSKTQ--LIIFSVVGFVVVL
                :     * *                   . .                          .

FGFR4_Hsap      LLLLAGLYRGQALHGRHP--RPPAT-VQKLS-RFPL-ARQFS--LESGSSGKSS-S----
FGFR3_Hsap      VVAAVTLCRLRSPPKKGL---GSPT-VHKIS-RFPL-KRQVS--LESNASMSSN-T----
FGFR2_Hsap      MVVTVILCRMKNTTKKPDF-SSQPA-VHKLTKRIPL-RRQVTVSAESSSSMNSN-T----
FGFR1_Hsap      MVGSVIVYKMKSGTKKSDF-HSQMA-VHKLAKSIPL-RRQVTVSADSSASMNSG-V----
htl_Dmel        MTTLFVFYAIRKMKHEKVLKQRIET-VHQWTKKVII-FKPEG-GGDSSGSMDTMIM----
btl_Dmel        G-SAFITFMLRRLRREKLLKLRIET-VHQWTKKVII-YRPGGEEGSGCSSGDLQ-M----
FGFR4_Mmus      LLLLAGVYHRQVIRGHYS--RQPVT-IQKLS-RFPL-ARQFS--LESRSSGKSS-L----
FGFR3_Mmus      VVAAVILCRLRSPPKKGL---GSPT-VHKVS-RFPL-KRQVS--LESNSSMNSN-T----
FGFR2_Mmus      MVVTVIFCRMKTTTKKPDF-SSQPA-VHKLTKRIPL-RRQVTVSAESSSSMNSN-T----
FGFR1_Mmus      MLGSVIIYKMKSGTKKSDF-HSQMA-VHKLAKSIPL-RRQVTVSADSSASMNSG-V----
egl-15_Cele     TLFGILFMVCKQTLHKKGFMDDTVGLVARKK-RVVVSKRPMNE--DNENSDDEP-SPYQI
FGFR_Spur       ILVTCIAILCKQTQVRHRRPSDKP----DISGPKHL-YRQTS--VDSTQS---I-A----
                          :    .                   :  :      ..  *

FGFR4_Hsap      -----SLV-----RG--VRL--SS--S-GPALLAGLVSLDLPLDPLWEFPRDRLVLGKPL
FGFR3_Hsap      -----PLV-----RI--ARL--SS--G-EGPTLANVSELELPADPKWELSRARLTLGKPL
FGFR2_Hsap      -----PLV-----RIT-TRL--SS--TADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPL
FGFR1_Hsap      -----LLV-----RP--SRL--SS--S-GTPMLAGVSEYELPEDPRWELPRDRLVLGKPL
htl_Dmel        -----PVV-----RIQKQRTTV--LQNG--NEPAPFNEYEFPLDSNWELPRSHLVLGATL
btl_Dmel        -----PVI-----RIEKQRTTVSTTGTGGTDPAQGFNEYEFPLDSNWEIPRQQLSLGSIL
FGFR4_Mmus      -----SLV-----RG--VRL--SS--S-GPPLLTGLVNLDLPLDPLWEFPRDRLVLGKPL
FGFR3_Mmus      -----PLV-----RI--ARL--SS--G-EGPVLANVSELELPADPKWELSRTRLTLGKPL
FGFR2_Mmus      -----PLV-----RIT-TRL--SS--TADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPL
FGFR1_Mmus      -----LLV-----RP--SRL--SS--S-GTPMLAGVSEYELPEDPRWELPRDRLVLGKPL
egl-15_Cele     QIIETPITKKEAARKQRKRM--NS---E----NTVLSEYEVDSDPVWEVERSKLSLVHML
FGFR_Spur       -----PLF-----GGR-NRL--TS--S-----LTVISEYDIPLDPEWEFPRDRLTVGKTI
                      :           *                . . :.  *. **. * :* :   :

FGFR4_Hsap      GEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNI
FGFR3_Hsap      GEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNI
FGFR2_Hsap      GEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNI
FGFR1_Hsap      GEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNI
htl_Dmel        GEGAFGRVVMAEV---------NNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINI
btl_Dmel        GEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINI
FGFR4_Mmus      GEGCFGQVVRAEAFGMDPSRPDQTSTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNI
FGFR3_Mmus      GEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNI
FGFR2_Mmus      GEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNI
FGFR1_Mmus      GEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNI
egl-15_Cele     GEGAFGEVWKATY----KETENNEIAVAVKKLKMSAHEKELIDLVSEMETFKVIGEHENV
FGFR_Spur       GEGAFGKVVIGEAVGIVC--QEKTSTVAVKMLKANAMDREFSDLISELAMMKMIGKNPNI
                ***.**.*  .               **** :*    : :: .*: *:  :*:**.: *:

FGFR4_Hsap      INLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDG-----------------
FGFR3_Hsap      INLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDT-----------------
FGFR2_Hsap      INLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDI-----------------
FGFR1_Hsap      INLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNP-----------------
htl_Dmel        INLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSS--------------QP
btl_Dmel        INLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRSDSDGYL-----------DD
FGFR4_Mmus      INLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDG-----------------
FGFR3_Mmus      INLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGMDYSFDA-----------------
FGFR2_Mmus      INLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDI-----------------
FGFR1_Mmus      INLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNP-----------------
egl-15_Cele     LRLIGCCTGAGPLYVVVELCKHGNLRDFLRAHRPKEEKAKKSSQELTDYLEPRKASDKDD
FGFR_Spur       INLLGCCTQEGPPYVIVEFAHHGNLRDFLRSRRPPE-EYEKSI-----------------
                :.*:* *:  ** :*:** . :***:::*  .**   .   .

FGFR4_Hsap      -PRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLAR
FGFR3_Hsap      -CKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLAR
FGFR2_Hsap      -NRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLAR
FGFR1_Hsap      -SHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLAR
htl_Dmel        PPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLAR
btl_Dmel        KPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLAR
FGFR4_Mmus      -PRSSEGPLSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLAR
FGFR3_Mmus      -CRLPEEQLTCKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLAR
FGFR2_Mmus      -NRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLAR
FGFR1_Mmus      -SHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLAR
egl-15_Cele     IELI--PNLTQRHLVQFAWQVAQGMNFLASKKIIHRDLAARNVLVGDGHVLKISDFGLSR
FGFR_Spur       -LLTTSQTLTNKDLMSMAYQVARGMDFLASKKCIHRDLAARNVLVTEDFEMKICDFGLAR
                        :    * . : *:*:**::* *:: ************ :.  :**.****:*

FGFR4_Hsap      GVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGI-P
FGFR3_Hsap      DVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGI-P
FGFR2_Hsap      DINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI-P
FGFR1_Hsap      DIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV-P
htl_Dmel        DIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMS
btl_Dmel        DIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILS
FGFR4_Mmus      GVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGI-P
FGFR3_Mmus      DVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGI-P
FGFR2_Mmus      DINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI-P
FGFR1_Mmus      DIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV-P
egl-15_Cele     DVHCNDYYRKRGNGRLPIKWMALEALDSNVYTVESDVWSYGVLLWEIMTLGGTPYPTI-A
FGFR_Spur       DIHYIDFYRKTTDGRLPVKWMAPEALFDRMFTTQSDVWSFGILLWEIMTLGGTPYPSV-P
                .::  ::*:*  :****:**** *:* .. :  :*****:*:*:***:* *  *** : .

FGFR4_Hsap      VEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLL-AV---
FGFR3_Hsap      VEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTS---
FGFR2_Hsap      VEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT---
FGFR1_Hsap      VEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTS---
htl_Dmel        AEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQ--T---
btl_Dmel        AEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDGILQQASSNP
FGFR4_Mmus      VEELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRPTFKQLVEALDKVLL-AV---
FGFR3_Mmus      VEELFKLLKEGHRMDKPASCTHDLYMIMRECWHAVPSQRPTFKQLVEDLDRILTVTS---
FGFR2_Mmus      VEELFKLLKEGHRMDKPTNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT---
FGFR1_Mmus      VEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTS---
egl-15_Cele     MPELYANLKEGYRMEPPHLCPQEVYHLMCSCWREKLEERPSFKTIVDYLDWMLTMTN---
FGFR_Spur       VEQMFDYLRSGKRLEKPQNTSLEIYHILCECWRTSPGQRPTFCELVEDLDRIISVSS---
                  :::  *  * *:: *   . ::* :: .**:     **.*  :*: :* ::

FGFR4_Hsap      SEEYLDLRLTFGPYSPSGGDA------------------------------SS-TCSS-S
FGFR3_Hsap      TDEYLDLSAPFEQYSPGGQDT------------------------------PSS-SSSGD
FGFR2_Hsap      NEEYLDLSQPLEQYSPSYPDT------------------------------RSS-CSSGD
FGFR1_Hsap      NQEYLDLSMPLDQYSPSFPDT------------------------------RSSTCSSGE
htl_Dmel        KEDYLDVDIANLDTPPSTSDE------------------------------EEDE-T---
btl_Dmel        NDAYLDLSMPMLETPPSSGDE------------------------------DDGS-D--T
FGFR4_Mmus      SEEYLDLRLTFGPFSPSNGDA------------------------------SS-TCSS-S
FGFR3_Mmus      TDEYLDLSVPFEQYSPGGQDT------------------------------PSS-SSSGD
FGFR2_Mmus      NEEYLDLTQPLEQYSPSYPDT------------------------------RSS-CSSGD
FGFR1_Mmus      NQEYLDLSIPLDQYSPSFPDT------------------------------RSSTCSSGE
egl-15_Cele     --ETIEGSQEFNDQFFSERSTASGPVSPMESFQKKRKHRPLSAPVNLPSEPQHTICDD-Y
FGFR_Spur       NQDYLDLEAVGDAPVKTFQES------------------------------ERM------
                    ::             .

FGFR4_Hsap      DSVFSHDPLPLGSS--------------------SF----PFGSGVQT
FGFR3_Hsap      DSVFAHDLLPPAP---------------------------PSSGGSRT
FGFR2_Hsap      DSVFSPDPMPYEPC-L-----------------PQYP---HINGSVKT
FGFR1_Hsap      DSVFSHEPLPEEPC-L-----------------PRHPAQLANGGLKRR
htl_Dmel        DN---------------------------------------LQKWCNY
btl_Dmel        ETFRETS-----PL--------------------R-----YQYTYKFN
FGFR4_Mmus      DSVFSHDPLPLEPS--------------------PF----PFSDSQTT
FGFR3_Mmus      DSVFTHDLLPPGP---------------------------PSNGGPRT
FGFR2_Mmus      DSVFSPDPMPYEPC-L-----------------PQYP---HINGSVKT
FGFR1_Mmus      DSVFSHEPLPEEPC-L-----------------PRHPTQLANSGLKRR
egl-15_Cele     ESNFSVEP-PNDPNHLYCNDNMLKNHIITPETSQRIPSNNNSMSKPEF
FGFR_Spur       --AFMGFRAPLSPQ-V------------Y----YKVPQT-RDCCPYAN