Protein (view, download) , Domain (view, download)
GSK3B_Hsap       MSGRPRTT----------------------------------------------------
GSK3A_Hsap       MSGGGPSGGGP----------------G--------------------------------
Pk34A_Dmel       MENKEKKQKPLK------------------------------------------------
sgg_Dmel         MFTFYTNINNTLINNNNNNNNTSNSNNNNNNVISQPIKIPLTERFSSQTSTGSADSGVIV
gskt_Dmel        MASQSKNSG---------------------------------------------------
GSK3B_Mmus       MSGRPRTT----------------------------------------------------
GSK3A_Mmus       MSGGGPSGGGP----------------G--------------------------------
R03D7.5_Cele     MANFIRLAYN--------------------------------------------------
F21F3.2_Cele     MSVTVEQ-----------------------------------------------------
C44H4.6_Cele     MNRMRRSTAFS-------------------------------------------------
C36B1.10_Cele    MPNTYRTSDE--------------------------------------------------
RIM11_Scer       MNIQSNNSPNLS------------------------------------------------
MRK1_Scer        MTDVLRSLVRKI------------------------------------------------
MCK1_Scer        MSTEEQNG--V-------------------------------------------------
Y106G6D.4_Cele   MNEDENKGIV--------------------------------------------------
Y106G6E.1_Cele   MPNIYRTTDE--------------------------------------------------
Y18D10A.5_Cele   MNKQLLSC----------------------------------------------------
YOL128C_Scer     MLKVNNVFGSN-------------------------------------------------
GlkA_Ddis        MTIPTDNNSSNN------------------------------------------------
GSK-3_Ddis       MSSKDQILE-K-------------------------------------------------
19912_Tthe       MLSQTVPLSSVL------------------------------------------------
19923_Tthe       MGGNGSRMH---------------------------------------------------
19924_Tthe       MNMRIPTQNYD-------------------------------------------------
2636_Tthe        MIKREILIKSKI------------------------------------------------
5825_Tthe        MNVSQSQGNVMQ------------------------------------------------
7876_Tthe        MYNNMTSNKPN-------------------------------------------------
GSK3_Spur        MCTVERPASGEW---------------S--------------------------------
n1163_Tthe       MAEFQQETEQLK------------------------------------------------
CC1G_03802_Ccin  MATHGPING---------------------------------------------------
AqueK117_Aque    MSSTFNKKEPP-------------------------------------------------
GSK_b_Smoe       MESRVDSMQ-E-------------------------------------------------
GSK_a-2_Smoe     MASASVGPVGA-------------------------------------------------
GSK_a-1_Smoe     MASASVGPVGA-------------------------------------------------
GK035_Glam       MLPQKLPEL---------------------------------------------------
GK036_Glam       MSDDETAFPPE-------------------------------------------------
                 *

GSK3B_Hsap       ------------------------------------------------------------
GSK3A_Hsap       ----------GSGRARTS------------------------------------------
Pk34A_Dmel       ------------------------------------------------------------
sgg_Dmel         SSASQQQLQLPPPRSSSG------------------------------------------
gskt_Dmel        ------------------------------------------------------------
GSK3B_Mmus       ------------------------------------------------------------
GSK3A_Mmus       ----------GSGRARTS------------------------------------------
R03D7.5_Cele     ------------------------------------------------------------
F21F3.2_Cele     ------------------------------------------------------------
C44H4.6_Cele     ------------------------------------------------------------
C36B1.10_Cele    ------------------------------------------------------------
RIM11_Scer       ------------------------------------------------------------
MRK1_Scer        -------------SFNNS------------------------------------------
MCK1_Scer        ------------------------------------------------------------
Y106G6D.4_Cele   ------------------------------------------------------------
Y106G6E.1_Cele   ------------------------------------------------------------
Y18D10A.5_Cele   ------------------------------------------------------------
YOL128C_Scer     ------------------------------------------------------------
GlkA_Ddis        ------------------------------------------------------------
GSK-3_Ddis       ------------------------------------------------------------
19912_Tthe       ------------------------------------------------------------
19923_Tthe       ------------------------------------------------------------
19924_Tthe       ------------------------------------------------------------
2636_Tthe        ------------------------------------------------------------
5825_Tthe        ----------------S-------------------------------------------
7876_Tthe        ------------------------------------------------------------
GSK3_Spur        ----------THRRPVSS------------------------------------------
n1163_Tthe       ----------------QLLQATYQGTSTEQVKHAEKELQNVSHHQDFLKYLVYIMKDTAN
CC1G_03802_Ccin  ------------------------------------------------------------
AqueK117_Aque    -------------RIRTT------------------------------------------
GSK_b_Smoe       ------------------------------------------------------------
GSK_a-2_Smoe     ------------IRGSTS------------------------------------------
GSK_a-1_Smoe     ------------IRGSTS------------------------------------------
GK035_Glam       ------------------------------------------------------------
GK036_Glam       ------------------------------------------------------------


GSK3B_Hsap       --------------------------------S---F-AES----C--------------
GSK3A_Hsap       --------------------------------S---F-AEP----G--------------
Pk34A_Dmel       --------------------------------R---H-----------------------
sgg_Dmel         --------------------------------S---L-SLP----Q--------------
gskt_Dmel        ------------------------------------L-----------------------
GSK3B_Mmus       --------------------------------S---F-AES----C--------------
GSK3A_Mmus       --------------------------------S---F-AEP----G--------------
R03D7.5_Cele     ------------------------------------------------------------
F21F3.2_Cele     ------------------------------------------------------------
C44H4.6_Cele     ------------------------------------------------------------
C36B1.10_Cele    ------------------------------------------------------------
RIM11_Scer       --------------------------------N---N--------I--------------
MRK1_Scer        --------------------------------D---NLQLKHKTSI--------------
MCK1_Scer        ------------------------------------P-----------------------
Y106G6D.4_Cele   ------------------------------------------------------------
Y106G6E.1_Cele   ------------------------------------------------------------
Y18D10A.5_Cele   --------------------------------S---L-----------------------
YOL128C_Scer     ------------------------------------P-----------------------
GlkA_Ddis        --------------------------------KGYND--------NNNNNNNNNNNNNNN
GSK-3_Ddis       ------------------------------------------------------------
19912_Tthe       --------------------------------E---VLPQQRVNA---------------
19923_Tthe       ------------------------------------------------------------
19924_Tthe       --------------------------------K---E--------V--------------
2636_Tthe        --------------------------------S--KN--------S--------------
5825_Tthe        --------------------------------Q---N--------L--------------
7876_Tthe        --------------------------------N---R--------L--------------
GSK3_Spur        --------------------------------A---Y-SKI----V--------------
n1163_Tthe       PLLMQKSASNYVHVYVRNIYSKTSQSGQIQQIQ---E--------I--------------
CC1G_03802_Ccin  ------------------------------------V-----------------------
AqueK117_Aque    --------------------------------S---F-ADP----M--------------
GSK_b_Smoe       ------------------------------------------------------------
GSK_a-2_Smoe     --------------------------------A---I-VVS-------------------
GSK_a-1_Smoe     --------------------------------A---I-VVS-------------------
GK035_Glam       ------------------------------------------------------------
GK036_Glam       ------------------------------------------------------------


GSK3B_Hsap       -K----------------------------------------------------------
GSK3A_Hsap       -G---------------GGGGGGGGPGGSASGP----GGTGGGKASVGAMGGGVGASSSG
Pk34A_Dmel       ------------------------------------------------------------
sgg_Dmel         -APPGGKWRQKQQRQQLLLSQDSGIENGVTTRPSKAKDNQGAGKASHNATS--SKESGAQ
gskt_Dmel        ------------------------------------------------------------
GSK3B_Mmus       -K----------------------------------------------------------
GSK3A_Mmus       -G---------------GGGGGGGGPGGSASGP----GGTGGGKASVGAMGGGVGASSSG
R03D7.5_Cele     ------------------------------------------------------------
F21F3.2_Cele     ------------------------------------------------------------
C44H4.6_Cele     ------------------------------------------------------------
C36B1.10_Cele    ------------------------------------------------------------
RIM11_Scer       ------------------------------------------------------------
MRK1_Scer        ------------------------------------------------------------
MCK1_Scer        ------------------------------------------------------------
Y106G6D.4_Cele   ------------------------------------------------------------
Y106G6E.1_Cele   ------------------------------------------------------------
Y18D10A.5_Cele   ------------------------------------------------------------
YOL128C_Scer     ------------------------------------------------------------
GlkA_Ddis        NN----------------------------------------------------------
GSK-3_Ddis       ------------------------------------------------------------
19912_Tthe       ------------------------------------------------------------
19923_Tthe       ------------------------------------------------------------
19924_Tthe       ------------------------------------------------------------
2636_Tthe        -I----------------------------------------------------------
5825_Tthe        ------------------------------------------------------------
7876_Tthe        ------------------------------------------------------------
GSK3_Spur        -M----------------------------------------------------------
n1163_Tthe       ------------------------------------------------------------
CC1G_03802_Ccin  ------------------------------------------------------------
AqueK117_Aque    -G----------------------------------------------------------
GSK_b_Smoe       ------------------------------------------------------------
GSK_a-2_Smoe     ------------------------------------------------------------
GSK_a-1_Smoe     ------------------------------------------------------------
GK035_Glam       ------------------------------------------------------------
GK036_Glam       ------------------------------------------------------------


GSK3B_Hsap       ---------------------------------------------P-V------------
GSK3A_Hsap       G--------------------------------GPGGSGGGGSGGP-G------------
Pk34A_Dmel       ------------------------------------------------------------
sgg_Dmel         SNSSSESLGSNCSEAQEQQRVRASSALELSSVDTPVIVGGVVSGGN-SILRSRIKYKSTN
gskt_Dmel        ------------------------------------------------------------
GSK3B_Mmus       ---------------------------------------------P-V------------
GSK3A_Mmus       G--------------------------------GPSGSGGGGSGGP-G------------
R03D7.5_Cele     ------------------------------------------------------------
F21F3.2_Cele     ------------------------------------------------------------
C44H4.6_Cele     ------------------------------------------------------------
C36B1.10_Cele    ------------------------------------------------------------
RIM11_Scer       ------------------------------------------------------------
MRK1_Scer        ------------------------------------------------------------
MCK1_Scer        ------------------------------------------------------------
Y106G6D.4_Cele   ------------------------------------------------------------
Y106G6E.1_Cele   ------------------------------------------------------------
Y18D10A.5_Cele   ------------------------------------------------------------
YOL128C_Scer     ------------------------------------------------------------
GlkA_Ddis        ------------------------------------------------------------
GSK-3_Ddis       ------------------------------------------------------------
19912_Tthe       -----------------------------------------------L------------
19923_Tthe       ------------------------------------------------------------
19924_Tthe       ------------------------------------------------------------
2636_Tthe        ------------------------------------------------------------
5825_Tthe        ------------------------------------------------------------
7876_Tthe        ------------------------------------------------------------
GSK3_Spur        ---------------------------------------------PRI------------
n1163_Tthe       ------------------------------------------------------------
CC1G_03802_Ccin  ------------------------------------------------------------
AqueK117_Aque    ----------------------------------------------RE------------
GSK_b_Smoe       ------------------------------------------------------------
GSK_a-2_Smoe     ----------------------------------------------KV------------
GSK_a-1_Smoe     ----------------------------------------------KV------------
GK035_Glam       ------------------------------------------------------------
GK036_Glam       ------------------------------------------------------------


GSK3B_Hsap       ---------------------------------------------------------Q--
GSK3A_Hsap       ------------------------------------------------------------
Pk34A_Dmel       ------------------------------------------------------------
sgg_Dmel         STGTQGFDVEDRIDEVDICDDDDVDCDDRGSEIEEEEEDQTEQEEEVDEVDAKPKNRL--
gskt_Dmel        ------------------------------------------------------------
GSK3B_Mmus       ---------------------------------------------------------Q--
GSK3A_Mmus       ------------------------------------------------------------
R03D7.5_Cele     ------------------------------------------------------------
F21F3.2_Cele     ------------------------------------------------------------
C44H4.6_Cele     ------------------------------------------------------------
C36B1.10_Cele    ------------------------------------------------------------
RIM11_Scer       ------------------------------------------------------------
MRK1_Scer        ---------------------------------------------------------Q--
MCK1_Scer        ------------------------------------------------------------
Y106G6D.4_Cele   ------------------------------------------------------------
Y106G6E.1_Cele   ------------------------------------------------------------
Y18D10A.5_Cele   ------------------------------------------------------------
YOL128C_Scer     ------------------------------------------------------------
GlkA_Ddis        ---------------------------------------------------------NNN
GSK-3_Ddis       ------------------------------------------------------------
19912_Tthe       ---------------------------------------------------------Q--
19923_Tthe       ------------------------------------------------------------
19924_Tthe       ---------------------------------------------------------L--
2636_Tthe        ---------------------------------------------------------PKA
5825_Tthe        ---------------------------------------------------------Q--
7876_Tthe        ---------------------------------------------------------N--
GSK3_Spur        ---------------------------------------------------------S--
n1163_Tthe       ---------------------------------------------------------T--
CC1G_03802_Ccin  ------------------------------------------------------------
AqueK117_Aque    ---------------------------------------------------------T--
GSK_b_Smoe       ------------------------------------------------------------
GSK_a-2_Smoe     ---------------------------------------------------------G--
GSK_a-1_Smoe     ---------------------------------------------------------G--
GK035_Glam       ------------------------------------------------------------
GK036_Glam       ------------------------------------------------------------


GSK3B_Hsap       -QP--S------------------------------------------------------
GSK3A_Hsap       -AG--T------------------------------------------------------
Pk34A_Dmel       ------------------------------------------------------------
sgg_Dmel         -LP--PDQAELTVAAAMARRRDAKSLATDGHIYFPLLKISEDPHIDSKLINRKDGLQDTM
gskt_Dmel        ------------------------------------------------------------
GSK3B_Mmus       -QP--S------------------------------------------------------
GSK3A_Mmus       -AG--T------------------------------------------------------
R03D7.5_Cele     ------------------------------------------------------------
F21F3.2_Cele     ------------------------------------------------------------
C44H4.6_Cele     ------------------------------------------------------------
C36B1.10_Cele    ------------------------------------------------------------
RIM11_Scer       ------------------------------------------------------------
MRK1_Scer        -SN--T------------------------------------------------------
MCK1_Scer        ------------------------------------------------------------
Y106G6D.4_Cele   ------------------------------------------------------------
Y106G6E.1_Cele   ------------------------------------------------------------
Y18D10A.5_Cele   ------------------------------------------------------------
YOL128C_Scer     ------------------------------------------------------------
GlkA_Ddis        N-----------------------------------------------------------
GSK-3_Ddis       ------------------------------------------------------------
19912_Tthe       -Q---Y------------------------------------------------------
19923_Tthe       ------------------------------------------------------------
19924_Tthe       ------------------------------------------------------------
2636_Tthe        FF----------------------------------------------------------
5825_Tthe        ------------------------------------------------------------
7876_Tthe        ------------------------------------------------------------
GSK3_Spur        -ST--K------------------------------------------------------
n1163_Tthe       ------------------------------------------------------------
CC1G_03802_Ccin  ------------------------------------------------------------
AqueK117_Aque    ------------------------------------------------------------
GSK_b_Smoe       ------------------------------------------------------------
GSK_a-2_Smoe     -GSGVD------------------------------------------------------
GSK_a-1_Smoe     -GSGVD------------------------------------------------------
GK035_Glam       ------------------------------------------------------------
GK036_Glam       ------------------------------------------------------------


GSK3B_Hsap       ----------------------------A-------------------------------
GSK3A_Hsap       ----------------------------S-------------------------------
Pk34A_Dmel       ------------------------------------------------------------
sgg_Dmel         YYLDEFGSPKLREKFARKQKQLLAKQQKQLMKRERRSEEQRKKRNTTVASNLAASGAVVD
gskt_Dmel        ------------------------------------------------------------
GSK3B_Mmus       ----------------------------A-------------------------------
GSK3A_Mmus       ----------------------------S-------------------------------
R03D7.5_Cele     ------------------------------------------------------------
F21F3.2_Cele     ------------------------------------------------------------
C44H4.6_Cele     ------------------------------------------------------------
C36B1.10_Cele    ------------------------------------------------------------
RIM11_Scer       ------------------------------------------------------------
MRK1_Scer        ----------------------------A-------------------------------
MCK1_Scer        ------------------------------------------------------------
Y106G6D.4_Cele   ------------------------------------------------------------
Y106G6E.1_Cele   ------------------------------------------------------------
Y18D10A.5_Cele   ------------------------------------------------------------
YOL128C_Scer     ------------------------------------------------------------
GlkA_Ddis        ------------------------------------------------------------
GSK-3_Ddis       ------------------------------------------------------------
19912_Tthe       ----------------------------A-------------------------------
19923_Tthe       ------------------------------------------------------------
19924_Tthe       ------------------------------------------------------------
2636_Tthe        ------------------------------------------------------------
5825_Tthe        ------------------------------------------------------------
7876_Tthe        ------------------------------------------------------------
GSK3_Spur        ----------------------------I-------------------------------
n1163_Tthe       ------------------------------------------------------------
CC1G_03802_Ccin  ------------------------------------------------------------
AqueK117_Aque    ------------------------------------------------------------
GSK_b_Smoe       ------------------------------------------------------------
GSK_a-2_Smoe     ----------------------------Q-------------------------------
GSK_a-1_Smoe     ----------------------------Q-------------------------------
GK035_Glam       ------------------------------------------------------------
GK036_Glam       ------------------------------------------------------------


GSK3B_Hsap       ------------------------F---------G-------------------------
GSK3A_Hsap       ------------------------F---------P-------------------------
Pk34A_Dmel       -----------------------------------A------------------------
sgg_Dmel         DTKDDYKQQPHCDTSSRSKNNSVPN---------P--P----------------------
gskt_Dmel        ------------------------------------------------------------
GSK3B_Mmus       ------------------------F---------G-------------------------
GSK3A_Mmus       ------------------------F---------P-------------------------
R03D7.5_Cele     ------------------------------------------------------------
F21F3.2_Cele     ------------------------------------------------------------
C44H4.6_Cele     ------------------------------------------------------------
C36B1.10_Cele    ------------------------------------------------------------
RIM11_Scer       ------------------------------------------------------------
MRK1_Scer        ------------------------LEK---KKRKPDTIKKVSDVQVHHTVPNFNNSSEYI
MCK1_Scer        ------------------------------------------------------------
Y106G6D.4_Cele   ------------------------------------------------------------
Y106G6E.1_Cele   ------------------------------------------------------------
Y18D10A.5_Cele   ------------------------------------------------------------
YOL128C_Scer     -----------------------------------N------------------------
GlkA_Ddis        ------------------------------NNKEHPN-----------------------
GSK-3_Ddis       ------------------------------------------------------------
19912_Tthe       ------------------------FGESPQKTKRSN---KTQD-----RVSLFNGS----
19923_Tthe       ------------------------------------------------------------
19924_Tthe       ----------------------------------PT------------------------
2636_Tthe        ------------------------FFFFFFKQFQQKN-----------------------
5825_Tthe        ----------------------------------QQ------------------------
7876_Tthe        -----------------------------------D------------------------
GSK3_Spur        ------------------------L---------PPSS----------------------
n1163_Tthe       ----------------------------------EQ------------------------
CC1G_03802_Ccin  ------------------------------------------------------------
AqueK117_Aque    ------------------------R---------PPQV----------------------
GSK_b_Smoe       ------------------------------------------------------------
GSK_a-2_Smoe     ------------------------L---------PEEM----------------------
GSK_a-1_Smoe     ------------------------L---------PEEM----------------------
GK035_Glam       ------------------------------------------------------------
GK036_Glam       ------------------------------------------------------------


GSK3B_Hsap       ------------------------------------------------------------
GSK3A_Hsap       ------------------------------------------------------------
Pk34A_Dmel       ------------------------------------------------------------
sgg_Dmel         ------------------------------------------------------------
gskt_Dmel        ------------------------------------------------------------
GSK3B_Mmus       ------------------------------------------------------------
GSK3A_Mmus       ------------------------------------------------------------
R03D7.5_Cele     ------------------------------------------------------------
F21F3.2_Cele     ------------------------------------------------------------
C44H4.6_Cele     ------------------------------------------------------------
C36B1.10_Cele    ------------------------------------------------------------
RIM11_Scer       ------------------------------------------------------------
MRK1_Scer        NDIENLIISKL-------------------------------------------------
MCK1_Scer        ------------------------------------------------------------
Y106G6D.4_Cele   ------------------------------------------------------------
Y106G6E.1_Cele   ------------------------------------------------------------
Y18D10A.5_Cele   ------------------------------------------------------------
YOL128C_Scer     ------------------------------------------------------------
GlkA_Ddis        ------------------------------------------------------------
GSK-3_Ddis       ------------------------------------------------------------
19912_Tthe       ---ASIMMTTI-------------------------------------------------
19923_Tthe       ------------------------------------------------------------
19924_Tthe       ----------Q-------------------------------------------------
2636_Tthe        ------------------------------------------------------------
5825_Tthe        ------------------------------------------------------------
7876_Tthe        ------------------------------------------------------------
GSK3_Spur        ------------------------------------------------------------
n1163_Tthe       ----------IILAMRDSNISIDCKHNISKGLSIILSLDRPQTWILQDDITQLASTLIIL
CC1G_03802_Ccin  ------------------------------------------------------------
AqueK117_Aque    ------------------------------------------------------------
GSK_b_Smoe       ------------------------------------------------------------
GSK_a-2_Smoe     ------------------------------------------------------------
GSK_a-1_Smoe     ------------------------------------------------------------
GK035_Glam       ------------------------------------------------------------
GK036_Glam       ------------------------------------------------------------


GSK3B_Hsap       ------------------------------------------------------------
GSK3A_Hsap       ------------------------------------------------------------
Pk34A_Dmel       ------------------------------------------------------------
sgg_Dmel         ------------------------------------------------------------
gskt_Dmel        ------------------------------------------------------------
GSK3B_Mmus       ------------------------------------------------------------
GSK3A_Mmus       ------------------------------------------------------------
R03D7.5_Cele     ------------------------------------------------------------
F21F3.2_Cele     ------------------------------------------------------------
C44H4.6_Cele     ------------------------------------------------------------
C36B1.10_Cele    ------------------------------------------------------------
RIM11_Scer       ------------------------------------------------------------
MRK1_Scer        ------------------------------------------------------------
MCK1_Scer        ------------------------------------------------------------
Y106G6D.4_Cele   ------------------------------------------------------------
Y106G6E.1_Cele   ------------------------------------------------------------
Y18D10A.5_Cele   ------------------------------------------------------------
YOL128C_Scer     ------------------------------------------------------------
GlkA_Ddis        ------------------------------------------------------------
GSK-3_Ddis       ------------------------------------------------------------
19912_Tthe       ------------------------------------------------------------
19923_Tthe       ------------------------------------------------------------
19924_Tthe       ------------------------------------------------------------
2636_Tthe        ------------------------------------------------------------
5825_Tthe        ------------------------------------------------------------
7876_Tthe        ------------------------------------------------------------
GSK3_Spur        ------------------------------------------------------------
n1163_Tthe       QTVIISTQQKEFLAHFFNLLNMPFCQVGSNYLTEITSSLQLLEKSQNEQETTQIFQKTVE
CC1G_03802_Ccin  ------------------------------------------------------------
AqueK117_Aque    ------------------------------------------------------------
GSK_b_Smoe       ------------------------------------------------------------
GSK_a-2_Smoe     ------------------------------------------------------------
GSK_a-1_Smoe     ------------------------------------------------------------
GK035_Glam       ------------------------------------------------------------
GK036_Glam       ------------------------------------------------------------


GSK3B_Hsap       ------------------------------------------------------------
GSK3A_Hsap       ------------------------------------------------------------
Pk34A_Dmel       ------------------------------------------------------------
sgg_Dmel         ------------------------------------------------------------
gskt_Dmel        ------------------------------------------------------------
GSK3B_Mmus       ------------------------------------------------------------
GSK3A_Mmus       ------------------------------------------------------------
R03D7.5_Cele     ------------------------------------------------------------
F21F3.2_Cele     ------------------------------------------------------------
C44H4.6_Cele     ------------------------------------------------------------
C36B1.10_Cele    ------------------------------------------------------------
RIM11_Scer       ------------------------------------------------------------
MRK1_Scer        ------------------------------------------------------------
MCK1_Scer        ------------------------------------------------------------
Y106G6D.4_Cele   ------------------------------------------------------------
Y106G6E.1_Cele   ------------------------------------------------------------
Y18D10A.5_Cele   ------------------------------------------------------------
YOL128C_Scer     ------------------------------------------------------------
GlkA_Ddis        ------------------------------------------------------------
GSK-3_Ddis       ------------------------------------------------------------
19912_Tthe       ------------------------------------------------------------
19923_Tthe       ------------------------------------------------------------
19924_Tthe       ------------------------------------------------------------
2636_Tthe        ------------------------------------------------------------
5825_Tthe        ------------------------------------------------------------
7876_Tthe        ------------------------------------------------------------
GSK3_Spur        ------------------------------------------------------------
n1163_Tthe       GIKVLNLWAIVLKDLIIQVMESKNRKLISFVLENEILANLICHGICVTLNTPLQIKDCLI
CC1G_03802_Ccin  ------------------------------------------------------------
AqueK117_Aque    ------------------------------------------------------------
GSK_b_Smoe       ------------------------------------------------------------
GSK_a-2_Smoe     ------------------------------------------------------------
GSK_a-1_Smoe     ------------------------------------------------------------
GK035_Glam       ------------------------------------------------------------
GK036_Glam       ------------------------------------------------------------


GSK3B_Hsap       ------------------------------------------------------------
GSK3A_Hsap       ------------------------------------------------------------
Pk34A_Dmel       ------------------------------------------------------------
sgg_Dmel         ------------------------------------------------------------
gskt_Dmel        ------------------------------------------------------------
GSK3B_Mmus       ------------------------------------------------------------
GSK3A_Mmus       ------------------------------------------------------------
R03D7.5_Cele     ------------------------------------------------------------
F21F3.2_Cele     ------------------------------------------------------------
C44H4.6_Cele     ------------------------------------------------------------
C36B1.10_Cele    ------------------------------------------------------------
RIM11_Scer       ------------------------------------------------------------
MRK1_Scer        ------------------------------------------------------------
MCK1_Scer        ------------------------------------------------------------
Y106G6D.4_Cele   ------------------------------------------------------------
Y106G6E.1_Cele   ------------------------------------------------------------
Y18D10A.5_Cele   ------------------------------------------------------------
YOL128C_Scer     ------------------------------------------------------------
GlkA_Ddis        ------------------------------------------------------------
GSK-3_Ddis       ------------------------------------------------------------
19912_Tthe       ------------------------------------------------------------
19923_Tthe       ------------------------------------------------------------
19924_Tthe       ------------------------------------------------------------
2636_Tthe        ------------------------------------------------------------
5825_Tthe        ------------------------------------------------------------
7876_Tthe        ------------------------------------------------------------
GSK3_Spur        ------------------------------------------------------------
n1163_Tthe       CTSGQSDFDDAANTLKSHLIKAYTRINRQMFAERSKFDIFKTQFFKLLQQSLPIILKGLM
CC1G_03802_Ccin  ------------------------------------------------------------
AqueK117_Aque    ------------------------------------------------------------
GSK_b_Smoe       ------------------------------------------------------------
GSK_a-2_Smoe     ------------------------------------------------------------
GSK_a-1_Smoe     ------------------------------------------------------------
GK035_Glam       ------------------------------------------------------------
GK036_Glam       ------------------------------------------------------------


GSK3B_Hsap       ------------------------------------------------------------
GSK3A_Hsap       ------------------------------------------------------------
Pk34A_Dmel       ------------------------------------------------------------
sgg_Dmel         ------------------------------------------------------------
gskt_Dmel        ------------------------------------------------------------
GSK3B_Mmus       ------------------------------------------------------------
GSK3A_Mmus       ------------------------------------------------------------
R03D7.5_Cele     ------------------------------------------------------------
F21F3.2_Cele     ------------------------------------------------------------
C44H4.6_Cele     ------------------------------------------------------------
C36B1.10_Cele    ------------------------------------------------------------
RIM11_Scer       ------------------------------------------------------------
MRK1_Scer        ------------------------------------------------------------
MCK1_Scer        ------------------------------------------------------------
Y106G6D.4_Cele   ------------------------------------------------------------
Y106G6E.1_Cele   ------------------------------------------------------------
Y18D10A.5_Cele   ------------------------------------------------------------
YOL128C_Scer     ------------------------------------------------------------
GlkA_Ddis        ------------------------------------------------------------
GSK-3_Ddis       ------------------------------------------------------------
19912_Tthe       ------------------------------------------------------------
19923_Tthe       ------------------------------------------------------------
19924_Tthe       ------------------------------------------------------------
2636_Tthe        ------------------------------------------------------------
5825_Tthe        ------------------------------------------------------------
7876_Tthe        ------------------------------------------------------------
GSK3_Spur        ------------------------------------------------------------
n1163_Tthe       LFCQQTPDFQDKLENKSLSSIVIECLKFSHICAEQSEFYKIFQDCSRVLLLEVIFPLMRS
CC1G_03802_Ccin  ------------------------------------------------------------
AqueK117_Aque    ------------------------------------------------------------
GSK_b_Smoe       ------------------------------------------------------------
GSK_a-2_Smoe     ------------------------------------------------------------
GSK_a-1_Smoe     ------------------------------------------------------------
GK035_Glam       ------------------------------------------------------------
GK036_Glam       ------------------------------------------------------------


GSK3B_Hsap       ------------------------------------------------------------
GSK3A_Hsap       ------------------------------------------------------------
Pk34A_Dmel       ------------------------------------------------------------
sgg_Dmel         ------------------------------------------------------------
gskt_Dmel        ------------------------------------------------------------
GSK3B_Mmus       ------------------------------------------------------------
GSK3A_Mmus       ------------------------------------------------------------
R03D7.5_Cele     ------------------------------------------------------------
F21F3.2_Cele     ------------------------------------------------------------
C44H4.6_Cele     ------------------------------------------------------------
C36B1.10_Cele    ------------------------------------------------------------
RIM11_Scer       ------------------------------------------------------------
MRK1_Scer        ------------------------------------------------------------
MCK1_Scer        ------------------------------------------------------------
Y106G6D.4_Cele   ------------------------------------------------------------
Y106G6E.1_Cele   ------------------------------------------------------------
Y18D10A.5_Cele   ------------------------------------------------------------
YOL128C_Scer     ------------------------------------------------------------
GlkA_Ddis        ------------------------------------------------------------
GSK-3_Ddis       ------------------------------------------------------------
19912_Tthe       ------------------------------------------------------------
19923_Tthe       ------------------------------------------------------------
19924_Tthe       ------------------------------------------------------------
2636_Tthe        ------------------------------------------------------------
5825_Tthe        ------------------------------------------------------------
7876_Tthe        ------------------------------------------------------------
GSK3_Spur        ------------------------------------------------------------
n1163_Tthe       SQSEQESLENNPEEFVRLALDTCDRQISYSYKCAAAKLLETVCDYIDGFETIVSLLLIQI
CC1G_03802_Ccin  ------------------------------------------------------------
AqueK117_Aque    ------------------------------------------------------------
GSK_b_Smoe       ------------------------------------------------------------
GSK_a-2_Smoe     ------------------------------------------------------------
GSK_a-1_Smoe     ------------------------------------------------------------
GK035_Glam       ------------------------------------------------------------
GK036_Glam       ------------------------------------------------------------


GSK3B_Hsap       ------------------------------------------------------------
GSK3A_Hsap       ------------------------------------------------------------
Pk34A_Dmel       ------------------------------------------------------------
sgg_Dmel         ------------------------------------------------------------
gskt_Dmel        ------------------------------------------------------------
GSK3B_Mmus       ------------------------------------------------------------
GSK3A_Mmus       ------------------------------------------------------------
R03D7.5_Cele     ------------------------------------------------------------
F21F3.2_Cele     ------------------------------------------------------------
C44H4.6_Cele     ------------------------------------------------------------
C36B1.10_Cele    ------------------------------------------------------------
RIM11_Scer       ------------------------------------------------------------
MRK1_Scer        ------------------------------------------------------------
MCK1_Scer        ------------------------------------------------------------
Y106G6D.4_Cele   ------------------------------------------------------------
Y106G6E.1_Cele   ------------------------------------------------------------
Y18D10A.5_Cele   ------------------------------------------------------------
YOL128C_Scer     ------------------------------------------------------------
GlkA_Ddis        ------------------------------------------------------------
GSK-3_Ddis       ------------------------------------------------------------
19912_Tthe       ------------------------------------------------------------
19923_Tthe       ------------------------------------------------------------
19924_Tthe       ------------------------------------------------------------
2636_Tthe        ------------------------------------------------------------
5825_Tthe        ------------------------------------------------------------
7876_Tthe        ------------------------------------------------------------
GSK3_Spur        ------------------------------------------------------------
n1163_Tthe       VGFSIKFENITDVDANYPNLIPFKETVFMSKTERHIRIETCFVALSVLSYLTPKRPDIVG
CC1G_03802_Ccin  ------------------------------------------------------------
AqueK117_Aque    ------------------------------------------------------------
GSK_b_Smoe       ------------------------------------------------------------
GSK_a-2_Smoe     ------------------------------------------------------------
GSK_a-1_Smoe     ------------------------------------------------------------
GK035_Glam       ------------------------------------------------------------
GK036_Glam       ------------------------------------------------------------


GSK3B_Hsap       ------------------------------------------------------------
GSK3A_Hsap       ------------------------------------------------------------
Pk34A_Dmel       ------------------------------------------------------------
sgg_Dmel         ------------------------------------------------------------
gskt_Dmel        ------------------------------------------------------------
GSK3B_Mmus       ------------------------------------------------------------
GSK3A_Mmus       ------------------------------------------------------------
R03D7.5_Cele     ------------------------------------------------------------
F21F3.2_Cele     ------------------------------------------------------------
C44H4.6_Cele     ------------------------------------------------------------
C36B1.10_Cele    ------------------------------------------------------------
RIM11_Scer       ------------------------------------------------------------
MRK1_Scer        ------------------------------------------------------------
MCK1_Scer        ------------------------------------------------------------
Y106G6D.4_Cele   ------------------------------------------------------------
Y106G6E.1_Cele   ------------------------------------------------------------
Y18D10A.5_Cele   ------------------------------------------------------------
YOL128C_Scer     ------------------------------------------------------------
GlkA_Ddis        ------------------------------------------------------------
GSK-3_Ddis       ------------------------------------------------------------
19912_Tthe       ------------------------------------------------------------
19923_Tthe       ------------------------------------------------------------
19924_Tthe       ------------------------------------------------------------
2636_Tthe        ------------------------------------------------------------
5825_Tthe        ------------------------------------------------------------
7876_Tthe        ------------------------------------------------------------
GSK3_Spur        ------------------------------------------------------------
n1163_Tthe       QIELLLKEHAQFLFNHNIHRLIKVRVCLMLGYYTDSVFQNEKENYKSLIQFLLSCLTLKE
CC1G_03802_Ccin  ------------------------------------------------------------
AqueK117_Aque    ------------------------------------------------------------
GSK_b_Smoe       ------------------------------------------------------------
GSK_a-2_Smoe     ------------------------------------------------------------
GSK_a-1_Smoe     ------------------------------------------------------------
GK035_Glam       ------------------------------------------------------------
GK036_Glam       ------------------------------------------------------------


GSK3B_Hsap       ------------------------------------------------------------
GSK3A_Hsap       ------------------------------------------------------------
Pk34A_Dmel       ------------------------------------------------------------
sgg_Dmel         ------------------------------------------------------------
gskt_Dmel        ------------------------------------------------------------
GSK3B_Mmus       ------------------------------------------------------------
GSK3A_Mmus       ------------------------------------------------------------
R03D7.5_Cele     ------------------------------------------------------------
F21F3.2_Cele     ------------------------------------------------------------
C44H4.6_Cele     ------------------------------------------------------------
C36B1.10_Cele    ------------------------------------------------------------
RIM11_Scer       ------------------------------------------------------------
MRK1_Scer        -IDGG-------------------------------------------------------
MCK1_Scer        ------------------------------------------------------------
Y106G6D.4_Cele   ------------------------------------------------------------
Y106G6E.1_Cele   ------------------------------------------------------------
Y18D10A.5_Cele   ------------------------------------------------------------
YOL128C_Scer     ------------------------------------------------------------
GlkA_Ddis        ------------------------------------------------------------
GSK-3_Ddis       ------------------------------------------------------------
19912_Tthe       -Q----------------------------------------------------------
19923_Tthe       ------------------------------------------------------------
19924_Tthe       -ADEG-------------------------------------------------------
2636_Tthe        ------------------------------------------------------------
5825_Tthe        ------------------------------------------------------------
7876_Tthe        ------------------------------------------------------------
GSK3_Spur        ------------------------------------------------------------
n1163_Tthe       QEDQGIVYQAIDSLQNIYDDDNQVNLVSENINEVLHVILPLITTTEFHQFMDIVFHIFRY
CC1G_03802_Ccin  ------------------------------------------------------------
AqueK117_Aque    ------------------------------------------------------------
GSK_b_Smoe       ------------------------------------------------------------
GSK_a-2_Smoe     ------------------------------------------------------------
GSK_a-1_Smoe     ------------------------------------------------------------
GK035_Glam       ------------------------------------------------------------
GK036_Glam       ------------------------------------------------------------


GSK3B_Hsap       ------------------------------------------------------------
GSK3A_Hsap       ------------------------------------------------------------
Pk34A_Dmel       ------------------------------------------------------------
sgg_Dmel         ------------------------------------------------------------
gskt_Dmel        ------------------------------------------------------------
GSK3B_Mmus       ------------------------------------------------------------
GSK3A_Mmus       ------------------------------------------------------------
R03D7.5_Cele     ------------------------------------------------------------
F21F3.2_Cele     ------------------------------------------------------------
C44H4.6_Cele     ------------------------------------------------------------
C36B1.10_Cele    ------------------------------------------------------------
RIM11_Scer       ------------------------------------------------------------
MRK1_Scer        ------------------------------------------------------------
MCK1_Scer        ------------------------------------------------------------
Y106G6D.4_Cele   ------------------------------------------------------------
Y106G6E.1_Cele   ------------------------------------------------------------
Y18D10A.5_Cele   ------------------------------------------------------------
YOL128C_Scer     ------------------------------------------------------------
GlkA_Ddis        ------------------------------------------------------------
GSK-3_Ddis       ------------------------------------------------------------
19912_Tthe       ------------------------------------------------------------
19923_Tthe       ------------------------------------------------------------
19924_Tthe       ------------------------------------------------------------
2636_Tthe        ------------------------------------------------------------
5825_Tthe        ------------------------------------------------------------
7876_Tthe        ------------------------------------------------------------
GSK3_Spur        ------------------------------------------------------------
n1163_Tthe       HSKNIAPQNIINCVGYLVKRIIDEVKLIDDKLRNDQIYINKCWNIIRDMSDNKFIVPQYI
CC1G_03802_Ccin  ------------------------------------------------------------
AqueK117_Aque    ------------------------------------------------------------
GSK_b_Smoe       ------------------------------------------------------------
GSK_a-2_Smoe     ------------------------------------------------------------
GSK_a-1_Smoe     ------------------------------------------------------------
GK035_Glam       ------------------------------------------------------------
GK036_Glam       ------------------------------------------------------------


GSK3B_Hsap       ------------------------------------------------------------
GSK3A_Hsap       ------------------------------------------------------------
Pk34A_Dmel       ------------------------------------------------------------
sgg_Dmel         ------------------------------------------------------------
gskt_Dmel        ------------------------------------------------------------
GSK3B_Mmus       ------------------------------------------------------------
GSK3A_Mmus       ------------------------------------------------------------
R03D7.5_Cele     ------------------------------------------------------------
F21F3.2_Cele     ------------------------------------------------------------
C44H4.6_Cele     ------------------------------------------------------------
C36B1.10_Cele    ------------------------------------------------------------
RIM11_Scer       ------------------------------------------------------------
MRK1_Scer        ------------------------------------------------------------
MCK1_Scer        ------------------------------------------------------------
Y106G6D.4_Cele   ------------------------------------------------------------
Y106G6E.1_Cele   ------------------------------------------------------------
Y18D10A.5_Cele   ------------------------------------------------------------
YOL128C_Scer     ------------------------------------------------------------
GlkA_Ddis        ------------------------------------------------------------
GSK-3_Ddis       ------------------------------------------------------------
19912_Tthe       ------------------------------------------------------------
19923_Tthe       ------------------------------------------------------------
19924_Tthe       ------------------------------------------------------------
2636_Tthe        ------------------------------------------------------------
5825_Tthe        ------------------------------------------------------------
7876_Tthe        ------------------------------------------------------------
GSK3_Spur        ------------------------------------------------------------
n1163_Tthe       NSILEQLRPLLQCVQYPEKIEFDEDIILLVGSFIYHQKAVNPICSDLITCFPLILKKQQG
CC1G_03802_Ccin  ------------------------------------------------------------
AqueK117_Aque    ------------------------------------------------------------
GSK_b_Smoe       ------------------------------------------------------------
GSK_a-2_Smoe     ------------------------------------------------------------
GSK_a-1_Smoe     ------------------------------------------------------------
GK035_Glam       ------------------------------------------------------------
GK036_Glam       ------------------------------------------------------------


GSK3B_Hsap       ------------------------------------------------------------
GSK3A_Hsap       ------------------------------------------------------------
Pk34A_Dmel       ------------------------------------------------------------
sgg_Dmel         ------------------------------------------------------------
gskt_Dmel        ------------------------------------------------------------
GSK3B_Mmus       ------------------------------------------------------------
GSK3A_Mmus       ------------------------------------------------------------
R03D7.5_Cele     ------------------------------------------------------------
F21F3.2_Cele     ------------------------------------------------------------
C44H4.6_Cele     ------------------------------------------------------------
C36B1.10_Cele    ------------------------------------------------------------
RIM11_Scer       ------------------------------------------------------------
MRK1_Scer        ---------------------------------------------------KEGIAVD--
MCK1_Scer        ------------------------------------------------------------
Y106G6D.4_Cele   ------------------------------------------------------------
Y106G6E.1_Cele   ------------------------------------------------------------
Y18D10A.5_Cele   ------------------------------------------------------------
YOL128C_Scer     ------------------------------------------------------------
GlkA_Ddis        ------------------------------------------------------------
GSK-3_Ddis       ------------------------------------------------------------
19912_Tthe       ------------------------------------------------------SKAD--
19923_Tthe       ------------------------------------------------------------
19924_Tthe       ---------------------------------------------------I-GSRVH--
2636_Tthe        ------------------------------------------------------------
5825_Tthe        ------------------------------------------------------------
7876_Tthe        ------------------------------------------------------------
GSK3_Spur        ------------------------------------------------------------
n1163_Tthe       VFAQLFKTLNNVIIYGQEFLIQNASHLQLIIKMAYDTMFSDSSKSTDSDKAE-GAAIMQL
CC1G_03802_Ccin  ------------------------------------------------------------
AqueK117_Aque    ------------------------------------------------------------
GSK_b_Smoe       ------------------------------------------------------------
GSK_a-2_Smoe     ------------------------------------------------------------
GSK_a-1_Smoe     ------------------------------------------------------------
GK035_Glam       ------------------------------------------------------------
GK036_Glam       ------------------------------------------------------------


GSK3B_Hsap       ------------------------------------------------------------
GSK3A_Hsap       ------------------------------------------------------------
Pk34A_Dmel       ------------------------------------------------------------
sgg_Dmel         ------------------------------------------------------------
gskt_Dmel        ------------------------------------------------------------
GSK3B_Mmus       ------------------------------------------------------------
GSK3A_Mmus       ------------------------------------------------------------
R03D7.5_Cele     ------------------------------------------------------------
F21F3.2_Cele     ------------------------------------------------------------
C44H4.6_Cele     ------------------------------------------------------------
C36B1.10_Cele    ------------------------------------------------------------
RIM11_Scer       ------------------------------------------------------------
MRK1_Scer        ------------------------------------------------------------
MCK1_Scer        ------------------------------------------------------------
Y106G6D.4_Cele   ------------------------------------------------------------
Y106G6E.1_Cele   ------------------------------------------------------------
Y18D10A.5_Cele   ------------------------------------------------------------
YOL128C_Scer     ------------------------------------------------------------
GlkA_Ddis        ------------------------------------------------------------
GSK-3_Ddis       ------------------------------------------------------------
19912_Tthe       ------------------------------------------------------------
19923_Tthe       ------------------------------------------------------------
19924_Tthe       ------------------------------------------------------------
2636_Tthe        ------------------------------------------------------------
5825_Tthe        ------------------------------------------------------------
7876_Tthe        ------------------------------------------------------------
GSK3_Spur        ------------------------------------------------------------
n1163_Tthe       IVQSLGNNLTDEMWKIIFNAAIQRFQSQTKLRHSFAYGRTAGIFLSGFNSNIQKSTQILT
CC1G_03802_Ccin  ------------------------------------------------------------
AqueK117_Aque    ------------------------------------------------------------
GSK_b_Smoe       ------------------------------------------------------------
GSK_a-2_Smoe     ------------------------------------------------------------
GSK_a-1_Smoe     ------------------------------------------------------------
GK035_Glam       ------------------------------------------------------------
GK036_Glam       ------------------------------------------------------------


GSK3B_Hsap       ------------------------------------------------------------
GSK3A_Hsap       ------------------------------------------------------------
Pk34A_Dmel       ------------------------------------------------------------
sgg_Dmel         ------------------------------------------------------------
gskt_Dmel        ------------------------------------------------------------
GSK3B_Mmus       ------------------------------------------------------------
GSK3A_Mmus       ------------------------------------------------------------
R03D7.5_Cele     ------------------------------------------------------------
F21F3.2_Cele     ------------------------------------------------------------
C44H4.6_Cele     ------------------------------------------------------------
C36B1.10_Cele    ------------------------------------------------------------
RIM11_Scer       ------------------------------------------------------------
MRK1_Scer        ------------------------------------------------------------
MCK1_Scer        ------------------------------------------------------------
Y106G6D.4_Cele   ------------------------------------------------------------
Y106G6E.1_Cele   ------------------------------------------------------------
Y18D10A.5_Cele   ------------------------------------------------------------
YOL128C_Scer     ------------------------------------------------------------
GlkA_Ddis        ------------------------------------------------------------
GSK-3_Ddis       ------------------------------------------------------------
19912_Tthe       ------------------------------------------------------------
19923_Tthe       ------------------------------------------------------------
19924_Tthe       ------------------------------------------------------------
2636_Tthe        ------------------------------------------------------------
5825_Tthe        ------------------------------------------------------------
7876_Tthe        ------------------------------------------------------------
GSK3_Spur        ------------------------------------------------------------
n1163_Tthe       EMGLLEQVIILCVSKLEMYKRNYDIKLFIMSMSKVIVQVSLDANKVLQIFDCLISLMMKQ
CC1G_03802_Ccin  ------------------------------------------------------------
AqueK117_Aque    ------------------------------------------------------------
GSK_b_Smoe       ------------------------------------------------------------
GSK_a-2_Smoe     ------------------------------------------------------------
GSK_a-1_Smoe     ------------------------------------------------------------
GK035_Glam       ------------------------------------------------------------
GK036_Glam       ------------------------------------------------------------


GSK3B_Hsap       ------------------------------------------------------------
GSK3A_Hsap       ------------------------------------------------------------
Pk34A_Dmel       ------------------------------------------------------------
sgg_Dmel         -------------SSHLHQNHNHLVVDVQEDVDDVNVVATSDVDSGVVKMRRHSHDNHYD
gskt_Dmel        ------------------------------------------------------------
GSK3B_Mmus       ------------------------------------------------------------
GSK3A_Mmus       ------------------------------------------------------------
R03D7.5_Cele     ------------------------------------------------------------
F21F3.2_Cele     ------------------------------------------------------------
C44H4.6_Cele     ------------------------------------------------------------
C36B1.10_Cele    ------------------------------------------------------------
RIM11_Scer       ------------------------------------------------------------
MRK1_Scer        -----------HIE----------------------------------------------
MCK1_Scer        ------------------------------------------------------------
Y106G6D.4_Cele   ------------------------------------------------------------
Y106G6E.1_Cele   ------------------------------------------------------------
Y18D10A.5_Cele   ------------------------------------------------------------
YOL128C_Scer     ------------------------------------------------------------
GlkA_Ddis        ------------IN----------------------------------------------
GSK-3_Ddis       ------------------------------------------------------------
19912_Tthe       -----------TLP----------------------------------------------
19923_Tthe       -----------TVG----------------------------------------------
19924_Tthe       -----------TVG----------------------------------------------
2636_Tthe        ------------LQ----------------------------------------------
5825_Tthe        -----------QLA----------------------------------------------
7876_Tthe        -----------EIN----------------------------------------------
GSK3_Spur        ------------------------------------------------------------
n1163_Tthe       KELEQKLEKKRKLK----------------------------------------------
CC1G_03802_Ccin  ------------------------------------------------------------
AqueK117_Aque    ------------------------------------------------------------
GSK_b_Smoe       ------------------------------------------------------------
GSK_a-2_Smoe     -------------H----------------------------------------------
GSK_a-1_Smoe     -------------H----------------------------------------------
GK035_Glam       ------------------------------------------------------------
GK036_Glam       ------------F-----------------------------------------------


GSK3B_Hsap       ------------------------------------------------------------
GSK3A_Hsap       ------------------------------------------------------------
Pk34A_Dmel       ------------------------------------------------------------
sgg_Dmel         RIPRSNAATITTRPQIDQQSSHHQNTEDVEQGAEPQIDGEADLDADADADSDGSGENVKT
gskt_Dmel        ------------------------------------------------------------
GSK3B_Mmus       ------------------------------------------------------------
GSK3A_Mmus       ------------------------------------------------------------
R03D7.5_Cele     ------------------------------------------------------------
F21F3.2_Cele     ------------------------------------------------------------
C44H4.6_Cele     ------------------------------------------------------------
C36B1.10_Cele    ------------------------------------------------------------
RIM11_Scer       ------------------------------------------------------------
MRK1_Scer        ------------------------------------------------------------
MCK1_Scer        ------------------------------------------------------------
Y106G6D.4_Cele   ------------------------------------------------------------
Y106G6E.1_Cele   ------------------------------------------------------------
Y18D10A.5_Cele   ------------------------------------------------------------
YOL128C_Scer     ------------------------------------------------------------
GlkA_Ddis        ------------------------------------------------------------
GSK-3_Ddis       ------------------------------------------------------------
19912_Tthe       --------------PID-------------------------------------------
19923_Tthe       ------------------------------------------------------------
19924_Tthe       ------------------------------------------------------------
2636_Tthe        ------------------------------------------------------------
5825_Tthe        ------------------------------------------------------------
7876_Tthe        ------------------------------------------------------------
GSK3_Spur        ------------------------------------------------------------
n1163_Tthe       ------------------------------------------------------------
CC1G_03802_Ccin  ------------------------------------------------------------
AqueK117_Aque    ------------------------------------------------------------
GSK_b_Smoe       ------------------------------------------------------------
GSK_a-2_Smoe     ------------------------------------------------------------
GSK_a-1_Smoe     ------------------------------------------------------------
GK035_Glam       ------------------------------------------------------------
GK036_Glam       ------------------------------------------------------------


GSK3B_Hsap       -------S------------M------KVSRD----------------------------
GSK3A_Hsap       -------P------------P------GVKLG----------------------------
Pk34A_Dmel       ---------------------------QVPL-----------------------------
sgg_Dmel         AKLARTQS------------C------KNQTG----------------------------
gskt_Dmel        ------------------------------------------------------------
GSK3B_Mmus       -------S------------M------KVSRD----------------------------
GSK3A_Mmus       -------P------------P------GVKLG----------------------------
R03D7.5_Cele     ------------------------------------------------------------
F21F3.2_Cele     ------------------------------------------------------------
C44H4.6_Cele     ------------------------------------------------------------
C36B1.10_Cele    ------------------------------------------------------------
RIM11_Scer       ------------------------------------------------------------
MRK1_Scer        -------H------------A------NISDS----------------------------
MCK1_Scer        ----------------------------LQR-----------------------------
Y106G6D.4_Cele   ------------------------------------------------------------
Y106G6E.1_Cele   ------------------------------------------------------------
Y18D10A.5_Cele   ------------------------------------------------------------
YOL128C_Scer     ---------------------------RMTKL----------------------------
GlkA_Ddis        -------NNNNNNNNNNNNNI------KESSS----------------------------
GSK-3_Ddis       ------------------------------------------------------------
19912_Tthe       ------QY------------SKYRQNTQASNS----------------------------
19923_Tthe       -------S------------M------KESDK----------------------------
19924_Tthe       -------S------------M------KENEY----------------------------
2636_Tthe        -------QFYKNQQQKNDTFI---------------------------------------
5825_Tthe        ----------------------------QQQQ----------------------------
7876_Tthe        ----------------------------QNHQ----------------------------
GSK3_Spur        -------S------------S------KSIRD----------------------------
n1163_Tthe       ----------------------------DDDNNNNSDDEGDDDDYDDDDDDDEDDDEEVD
CC1G_03802_Ccin  ---------------------------KISPI----------------------------
AqueK117_Aque    ------GG------------M------RVTRD----------------------------
GSK_b_Smoe       ------------------------------------------------------------
GSK_a-2_Smoe     -------E------------M------KIRDD----------------------------
GSK_a-1_Smoe     -------E------------M------KIRDD----------------------------
GK035_Glam       ------------------------------------------------------------
GK036_Glam       ------------------------------------------------------------


GSK3B_Hsap       ------------------------------------------------------------
GSK3A_Hsap       ------------------------------------------------------------
Pk34A_Dmel       ------------------------------------------------------------
sgg_Dmel         ------------------------------------------------------------
gskt_Dmel        ------------------------------------------------------------
GSK3B_Mmus       ------------------------------------------------------------
GSK3A_Mmus       ------------------------------------------------------------
R03D7.5_Cele     ------------------------------------------------------------
F21F3.2_Cele     ------------------------------------------------------------
C44H4.6_Cele     ------------------------------------------------------------
C36B1.10_Cele    ------------------------------------------------------------
RIM11_Scer       ------------------------------------------------------------
MRK1_Scer        ------------------------------------------------------------
MCK1_Scer        ------------------------------------------------------------
Y106G6D.4_Cele   ------------------------------------------------------------
Y106G6E.1_Cele   ------------------------------------------------------------
Y18D10A.5_Cele   ------------------------------------------------------------
YOL128C_Scer     ------------------------------------------------------------
GlkA_Ddis        ------------------------------------------------------------
GSK-3_Ddis       ------------------------------------------------------------
19912_Tthe       ------------------------------------------------------------
19923_Tthe       ------------------------------------------------------------
19924_Tthe       ------------------------------------------------------------
2636_Tthe        ------------------------------------------------------------
5825_Tthe        ------------------------------------------------------------
7876_Tthe        ------------------------------------------------------------
GSK3_Spur        ------------------------------------------------------------
n1163_Tthe       GDEDNDLNVNHYDKEYDCSVNADKLMLKEMVSPINDVDEFAIFKQSYSTMKSQNFTALQQ
CC1G_03802_Ccin  ------------------------------------------------------------
AqueK117_Aque    ------------------------------------------------------------
GSK_b_Smoe       ------------------------------------------------------------
GSK_a-2_Smoe     ------------------------------------------------------------
GSK_a-1_Smoe     ------------------------------------------------------------
GK035_Glam       ------------------------------------------------------------
GK036_Glam       ------------------------------------------------------------


GSK3B_Hsap       ---------------------------------K--------------------------
GSK3A_Hsap       ---------------------------------R--------------------------
Pk34A_Dmel       ---------------------------------I--------------------------
sgg_Dmel         ---------------------------------R--------------------------
gskt_Dmel        ------------------------------------------------------------
GSK3B_Mmus       ---------------------------------K--------------------------
GSK3A_Mmus       ---------------------------------R--------------------------
R03D7.5_Cele     ------------------------------------------------------------
F21F3.2_Cele     ------------------------------------------------------------
C44H4.6_Cele     ------------------------------------------------------------
C36B1.10_Cele    ------------------------------------------------------------
RIM11_Scer       ------------------------------------------------------------
MRK1_Scer        ---------------------------------K--------------------------
MCK1_Scer        ------------------------------------------------------------
Y106G6D.4_Cele   ------------------------------------------------------------
Y106G6E.1_Cele   ------------------------------------------------------------
Y18D10A.5_Cele   ---------------------------------K--------------------------
YOL128C_Scer     ---------------------------------E--------------------------
GlkA_Ddis        ---------------------------------S--------------------------
GSK-3_Ddis       ------------------------------------------------------------
19912_Tthe       ---------------------------------K--------------------------
19923_Tthe       ---------------------------------K--------------------------
19924_Tthe       ---------------------------------Q--------------------------
2636_Tthe        ---------------------------------L--------------------------
5825_Tthe        ---------------------------------A--------------------------
7876_Tthe        ---------------------------------K--------------------------
GSK3_Spur        ---------------------------------K--------------------------
n1163_Tthe       LVYGLNQEKQKYLAQLLSVQRVNVGSEQVIRLRGGGGECHLISFISILKNIIYIFRIQKR
CC1G_03802_Ccin  ---------------------------------D--------------------------
AqueK117_Aque    ---------------------------------K--------------------------
GSK_b_Smoe       ------------------------------------------------------------
GSK_a-2_Smoe     ---------------------------------K--------------------------
GSK_a-1_Smoe     ---------------------------------K--------------------------
GK035_Glam       ------------------------------------------------------------
GK036_Glam       ------------------------------------------------------------


GSK3B_Hsap       ------------------------------------------------------------
GSK3A_Hsap       ------------------------------------------------------------
Pk34A_Dmel       ------------------------------------------------------------
sgg_Dmel         ------------------------------------------------------------
gskt_Dmel        ------------------------------------------------------------
GSK3B_Mmus       ------------------------------------------------------------
GSK3A_Mmus       ------------------------------------------------------------
R03D7.5_Cele     ------------------------------------------------------------
F21F3.2_Cele     ------------------------------------------------------------
C44H4.6_Cele     ------------------------------------------------------------
C36B1.10_Cele    ------------------------------------------------------------
RIM11_Scer       ------------------------------------------------------------
MRK1_Scer        ------------------------------------------------------------
MCK1_Scer        ------------------------------------------------------------
Y106G6D.4_Cele   ------------------------------------------------------------
Y106G6E.1_Cele   ------------------------------------------------------------
Y18D10A.5_Cele   ------------------------------------------------------------
YOL128C_Scer     ------------------------------------------------------------
GlkA_Ddis        ------------------------------------------------------------
GSK-3_Ddis       ------------------------------------------------------------
19912_Tthe       ------------------------------------------------------------
19923_Tthe       ------------------------------------------------------------
19924_Tthe       ------------------------------------------------------------
2636_Tthe        ------------------------------------------------------------
5825_Tthe        ------------------------------------------------------------
7876_Tthe        ------------------------------------------------------------
GSK3_Spur        ------------------------------------------------------------
n1163_Tthe       IFADLSASALEIIFSSRQIENLIFEISHFFRKMKESFFTLKKFNFRKENENLRINRLVSY
CC1G_03802_Ccin  ------------------------------------------------------------
AqueK117_Aque    ------------------------------------------------------------
GSK_b_Smoe       ------------------------------------------------------------
GSK_a-2_Smoe     ------------------------------------------------------------
GSK_a-1_Smoe     ------------------------------------------------------------
GK035_Glam       ------------------------------------------------------------
GK036_Glam       ------------------------------------------------------------


GSK3B_Hsap       ------------------------------------------------------------
GSK3A_Hsap       ------------------------------------------------------------
Pk34A_Dmel       ------------------------------------------------------------
sgg_Dmel         ------------------------------------------------------------
gskt_Dmel        ------------------------------------------------------------
GSK3B_Mmus       ------------------------------------------------------------
GSK3A_Mmus       ------------------------------------------------------------
R03D7.5_Cele     ------------------------------------------------------------
F21F3.2_Cele     ------------------------------------------------------------
C44H4.6_Cele     ------------------------------------------------------------
C36B1.10_Cele    ------------------------------------------------------------
RIM11_Scer       ------------------------------------------------------------
MRK1_Scer        -----------T------------------------------------------------
MCK1_Scer        ------------------------------------------------------------
Y106G6D.4_Cele   ------------------------------------------------------------
Y106G6E.1_Cele   ------------------------------------------------------------
Y18D10A.5_Cele   ------------------------------------------------------------
YOL128C_Scer     ------------------------------------------------------------
GlkA_Ddis        ------------------------------------------------------------
GSK-3_Ddis       ------------------------------------------------------------
19912_Tthe       -----------SPQ----------------------------------------------
19923_Tthe       -----------QD-----------------------------------------------
19924_Tthe       ------------K-----------------------------------------------
2636_Tthe        ------------------------------------------------------------
5825_Tthe        ------------------------------------------------------------
7876_Tthe        ------------------------------------------------------------
GSK3_Spur        ------------------------------------------------------------
n1163_Tthe       KNLQGKGAIDLRPPTSSQFQKTISFLERMRDKQIDRNKRQQQIKLAEKEQMTDHSLTNLF
CC1G_03802_Ccin  ------------------------------------------------------------
AqueK117_Aque    ------------------------------------------------------------
GSK_b_Smoe       ------------------------------------------------------------
GSK_a-2_Smoe     -----------TDH----------------------------------------------
GSK_a-1_Smoe     -----------TDH----------------------------------------------
GK035_Glam       ------------------------------------------------------------
GK036_Glam       ------------------------------------------------------------


GSK3B_Hsap       ------------------------------------------------------------
GSK3A_Hsap       ------------------------------------------------------------
Pk34A_Dmel       ------------------------------------------------------------
sgg_Dmel         ------------------------------------------------------------
gskt_Dmel        ------------------------------------------------------------
GSK3B_Mmus       ------------------------------------------------------------
GSK3A_Mmus       ------------------------------------------------------------
R03D7.5_Cele     ------------------------------------------------------------
F21F3.2_Cele     ------------------------------------------------------------
C44H4.6_Cele     ------------------------------------------------------------
C36B1.10_Cele    ------------------------------------------------------------
RIM11_Scer       ------------------------------------------------------------
MRK1_Scer        ------------------------------------------------------------
MCK1_Scer        ------------------------------------------------------------
Y106G6D.4_Cele   ------------------------------------------------------------
Y106G6E.1_Cele   ------------------------------------------------------------
Y18D10A.5_Cele   ------------------------------------------------------------
YOL128C_Scer     ------------------------------------------------------------
GlkA_Ddis        ------------------------------------------------------------
GSK-3_Ddis       --------------------------------------------------------DK-K
19912_Tthe       --------------------------------------AKNKKYNYGGGGDFFTQKI---
19923_Tthe       --------------------------------------PKVQ-------------KL---
19924_Tthe       --------------------------------------KQQQ-------------KI---
2636_Tthe        ------------------------------------------------------------
5825_Tthe        --------------------------------------QQQQ-------------Q----
7876_Tthe        ------------------------------------------------------------
GSK3_Spur        ------------------------------------------------------------
n1163_Tthe       IEQVLISFSNQLIIKQNKQSKQSANNQLQKKESKTGNQKRKK-------------KI---
CC1G_03802_Ccin  ------------------------------------------------------------
AqueK117_Aque    ------------------------------------------------------------
GSK_b_Smoe       --------------------------------------------------------VEAA
GSK_a-2_Smoe     --------------------------------------SDDK-------------ELEAT
GSK_a-1_Smoe     --------------------------------------SDDK-------------ELEAT
GK035_Glam       ------------------------------------------------------------
GK036_Glam       ------------------------------------------------------------


GSK3B_Hsap       --------------D--GSK--V-------------------------------------
GSK3A_Hsap       --------------D--SGK--V-------------------------------------
Pk34A_Dmel       ------------------IP--K-------------------------------------
sgg_Dmel         --------------D--GSK--I-------------------------------------
gskt_Dmel        -----------------TNK--V-------------------------------------
GSK3B_Mmus       --------------D--GSK--V-------------------------------------
GSK3A_Mmus       --------------D--SGK--V-------------------------------------
R03D7.5_Cele     ------------------------------------------------------------
F21F3.2_Cele     ------------------------------------------------------------
C44H4.6_Cele     --------------E--HVT--F-------------------------------------
C36B1.10_Cele    ------------------------------------------------------------
RIM11_Scer       --------------V--SKQ--V-------------------------------------
MRK1_Scer        --DGK--VANKHENI--SSK--L-------------------------------------
MCK1_Scer        --------------G--SEF--I-------------------------------------
Y106G6D.4_Cele   ------------------------------------------------------------
Y106G6E.1_Cele   ------------------------------------------------------------
Y18D10A.5_Cele   --------------S--GKQ--V-------------------------------------
YOL128C_Scer     --------------D--EHY--F-------------------------------------
GlkA_Ddis        --------------N--SNH--S-------------------------------------
GSK-3_Ddis       ETDD----------N--GNK-KT-------------------------------------
19912_Tthe       -SKKQPSLHTQQS-NSTYNQLRS-------------------------------------
19923_Tthe       ---------------------QI-------------------------------------
19924_Tthe       ---------------------QM-------------------------------------
2636_Tthe        --------------L--AD---D-------------------------------------
5825_Tthe        ------------------------------------------------------------
7876_Tthe        ------------------------------------------------------------
GSK3_Spur        --------------D--SSK--I-------------------------------------
n1163_Tthe       ---------------------QFQMNNMKKQYGQPMNVSQSQGNVMQSQNLQQQQLAQQQ
CC1G_03802_Ccin  --------------D--PHK--V-------------------------------------
AqueK117_Aque    --------------D-TGHR--I-------------------------------------
GSK_b_Smoe       VIDG----------N--GTE--T-------------------------------------
GSK_a-2_Smoe     VVDG----------N--GTE--T-------------------------------------
GSK_a-1_Smoe     VVDG----------N--GTE--T-------------------------------------
GK035_Glam       ----------------------F-------------------------------------
GK036_Glam       -----------------ELQ--L-------------------------------------


GSK3B_Hsap       ----TT-----VV-----------------------ATP-G-QGP------------DRP
GSK3A_Hsap       ----TT-----VV-----------------------ATL-G-QGP------------ERS
Pk34A_Dmel       ----NS-----VI-----------------------STYAVGRLC------------SEP
sgg_Dmel         ----TT-----VV-----------------------ATP-G-QGT------------DRV
gskt_Dmel        ----TT-----VV-----------------------ATN-A-FGA------------DVM
GSK3B_Mmus       ----TT-----VV-----------------------ATP-G-QGP------------DRP
GSK3A_Mmus       ----TT-----VV-----------------------ATV-G-QGP------------ERS
R03D7.5_Cele     -----L-----E------------------------VWKL--IEV------------HKT
F21F3.2_Cele     ------------E-----------------------AYEM--PAD------------NKK
C44H4.6_Cele     ----HT-----VM-----------------------AKRGTGSKL------------DRE
C36B1.10_Cele    -----------IV-----------------------AQR---LED------------GRD
RIM11_Scer       ----YY------------------------------AHPPPTIDP------------NDP
MRK1_Scer        ----SKEKVEKMINFDYRYIKTKERTIHKRVYKHDRKTDVDRKNH------------GGT
MCK1_Scer        ----AD-----DV-------------------------T-S-NKS------------NNT
Y106G6D.4_Cele   -----F-----QI-----------------------AYEL--PS-------------QQR
Y106G6E.1_Cele   -----------IV-----------------------AQR---LED------------GKD
Y18D10A.5_Cele   ----TM-----VV-----------------------ASV-ATDGV------------DQQ
YOL128C_Scer     ----ID-----DI-------------------------V-S-IKN------------RQK
GlkA_Ddis        ----SS-----QS-----------------------S-STA-TVN------------SNP
GSK-3_Ddis       ----TT-----TT-----------------------SSSSSSSSSSKPRSNKFDKVIIKS
19912_Tthe       ----SS-LTNRFN-----------------------KTP--SRLF------------NIN
19923_Tthe       ----LK-----RI-----------------------YE-IQFTQQ------------QKE
19924_Tthe       ----T------YF-----------------------YN-EKQQAG------------NYT
2636_Tthe        ----TI-----KV-----------------------F-PLL-KLD------------KMI
5825_Tthe        ------------L-----------------------QQ-QQQEQL------------QYS
7876_Tthe        ------------L-----------------------DH--KG------------------
GSK3_Spur        ----TS-----VT-----------------------ATK-G-PPP------------DRA
n1163_Tthe       QAQQQQ-----QL-----------------------QQ-QQQEQL------------QYS
CC1G_03802_Ccin  ----VR-----VI-----------------------ASD-G-KT-------------GET
AqueK117_Aque    ----MT-----VM-----------------------GTL-G-PLP------------DRQ
GSK_b_Smoe       ----GH-----II-----------------------ATTIGGRNG------------QPK
GSK_a-2_Smoe     ----GH-----II-----------------------ATTIGGRNG------------QPK
GSK_a-1_Smoe     ----GH-----II-----------------------ATTIGGRNG------------QPK
GK035_Glam       ----QD-----ST-----------------------ATC-P-QS-------------TDG
GK036_Glam       ----GK-----AL-------------------------DI--PGE------------KGE


GSK3B_Hsap       QEVSYTDTKVIGNGSFGVVYQAK-------------LC---DSG----ELVAIKKVLQDK
GSK3A_Hsap       QEVAYTDIKVIGNGSFGVVYQAR-------------LA---ETR----ELVAIKKVLQDK
Pk34A_Dmel       ALVRIEVKDLIGSGSFGRVYQAH-------------VN---ESE----EIVAVKQTLYNP
sgg_Dmel         QEVSYTDTKVIGNGSFGVVFQAK-------------LC---DTG----ELVAIKKVLQDR
gskt_Dmel        SEISYTDAKVVGNGSFGVVFQAK-------------MV---PSN----EMVAIKKVLQDR
GSK3B_Mmus       QEVSYTDTKVIGNGSFGVVYQAK-------------LC---DSG----ELVAIKKVLQDK
GSK3A_Mmus       QEVAYTDIKVIGNGSFGVVYQAR-------------LA---ETR----ELVAIKKVLQDK
R03D7.5_Cele     TKKAISAHKLCGSGRFSNVYCGQ-------------MI---SP-IE--KEVAVKNVWSDT
F21F3.2_Cele     VMLKIEEVHLHSCGVFSNVYKGI-------------LR---EP-YE--KKIAIKKSWPEK
C44H4.6_Cele     VEIQFTNLQLIGTGSFGAVYKAV-------------LR---END----EPIAIKKIKVDD
C36B1.10_Cele    MNLSLQNMNLFASGAFSNVYRGI-------------ART--ESNHQ--MEIVIKKTWPRH
RIM11_Scer       VQISFPTTEVVGHGSFGVVFATV-------------IQ---ETN----EKVAIKKVLQDK
MRK1_Scer        IDISYPTTEVVGHGSFGVVVTTV-------------II---ETN----QKVAIKKVLQDR
MCK1_Scer        RRMLVKEYRKIGRGAFGTVVQAY-------------LT---QDKKNWLGPFAIKKVPAHT
Y106G6D.4_Cele   VGMQMANLRLHARGVFSNVYRGT-------------IL---SPGTE--QEIAIKKTWPKT
Y106G6E.1_Cele   MHLNLHHMNLFATGAFSNVYRGV-------------AQT--ESNQE--IDIVIKKTWPRH
Y18D10A.5_Cele   VEISYYDQKVIGNGSFGVVFLAK-------------LS---TTN----EMVAIKKVLQDK
YOL128C_Scer     SKMYVREGKRIGHGSFGTVTQSI-------------LS---SNSIEWLGPYAIKRVVKSP
GlkA_Ddis        KVYPYEIIKQVGQGTFGKVYEAK-------------NQ---D-N----KRVAIKKVEKSN
GSK-3_Ddis       NGVCYITEGVIGNGSFGVVTQAI-------------VA---DTK----EVVAIKKVLQDQ
19912_Tthe       QNLDIDENNKIGQGNFGVVFKAE-------------FK---DTK----EEVAVKRVLQDK
19923_Tthe       YTYSIQGDNIVGNGTFGA----T-------------IN---ETG----ETVAIKKVFQDR
19924_Tthe       YTIVGDEDKVVGSGTFGVVYQAT-------------TK---ETG----EVVAIKKVFQDK
2636_Tthe        PLPNYEIKRVIGSGSFGYVFEAY-------------DN---NNQ----RTVALKRIQKVG
5825_Tthe        GSPNITLDKIIGNGTFGVVYLAK-------------MN---DTQ----EQVAIKKVFQDK
7876_Tthe        PPKDLKIIDVVGNGTFGVVYKKLDDNINFNYLKMKALL---NKE----QVVAVKRVFQDK
GSK3_Spur        EEISYTDTRVIGNGSFGVVYQAR-------------MV---DSS----DLVAIKKVLQDK
n1163_Tthe       GSPNITLDKIIGNGTFGVVYLAK-------------MN---DTQ----EQVAIKKVFQDK
CC1G_03802_Ccin  RELSYTNCKVIGNGSFGVVFQAR-------------LLGVPKDQ----EDIAIKKVLQDK
AqueK117_Aque    QEITYTDLKVIGSGSFGVVYQAK-------------IL---ETN----EPIAIKKVLQDK
GSK_b_Smoe       QTISYVAERVVGTGSFGIVFQAK-------------CL---ETG----ETVAIKKVLQDK
GSK_a-2_Smoe     QTISYVAERVVGTGSFGIVFQAK-------------CL---ETG----ETVAIKKVLQDK
GSK_a-1_Smoe     QTISYVAERVVGTGSFGIVFQAK-------------CL---ETG----ETVAIKKVLQDK
GK035_Glam       PEITFTTMRTIGSGSFGVVFIAK-------------T----STG----ELIAIKKVFQDR
GK036_Glam       EGIQVVPEKVIGKGSFGVVYLVK-------------SL---KGN----TPLALKLVLQDR
                            . * *.                                  .:*

GSK3B_Hsap       RFKN------RELQIM---RKL-DHCNIVRLR-YFFYSSGE-------------------
GSK3A_Hsap       RFKN------RELQIM---RKL-DHCNIVRLR-YFFYSSGE-------------------
Pk34A_Dmel       KLSQ------GEAEIMGQL--K-DHNNIVRLI-MHSSVSLG-------------------
sgg_Dmel         RFKN------RELQIM---RKL-EHCNIVKLL-YFFYSSGE-------------------
gskt_Dmel        RFKN------RELQIM---RKL-RHDNIITLK-WFFFSSGE-------------------
GSK3B_Mmus       RFKN------RELQIM---RKL-DHCNIVRLR-YFFYSSGE-------------------
GSK3A_Mmus       RFKN------RELQIM---RKL-DHCNIVRLR-YFFYSSGE-------------------
R03D7.5_Cele     ETRHLATSEYPEIQIL---SKL-FHPAISNLL-YFYSRNAND------------------
F21F3.2_Cele     GERN------FEFIFLTGRERA-KHKNVIHMI-FAFSHSYDT------------------
C44H4.6_Cele     RFKS------RELTIM---HEM-DHPNIIRLL-YYYVM----------------------
C36B1.10_Cele    KGCP------LEVKILGKLGKL-KHKNIVRLL-FSY-QK-Q-------------------
RIM11_Scer       RFKN------RELEIM---KML-SHINIIDLK-YFFYERD--------------------
MRK1_Scer        RYKN------RELETM---KML-CHPNTVGLQ-YYFYEKD--------------------
MCK1_Scer        EYKS------RELQIL---RIA-DHPNIVKLQ-YFFTHLSP-------------------
Y106G6D.4_Cele   PYRN------FELLFLSGLRRK-PHKNIVQML-FAFSRNTTSGEGLE-------------
Y106G6E.1_Cele   KGCP------MEVKILGQLGKL-KHRNIVRLL-YSY-QK-Q-------------------
Y18D10A.5_Cele   RFKN------RELQIM---RKL-NHPNIVKLK-YFFYSSGE-------------------
YOL128C_Scer     KVQS------LELEIL---QNI-RHPNLVTLE-FFFESHCT-------------------
GlkA_Ddis        HFIS------REYDIL---KIVA-HPNCLRIL-DMFYTAE--------------------
GSK-3_Ddis       RYKN------RELQIM---KML-NHINIVSLK-NSFYTS---------------------
19912_Tthe       NFKN------RELQIM---QEVAHHPNIVQLK-YSFYSFGE-------------------
19923_Tthe       RYKN------RELQIM---KEIGNHPNVISLR-NYFYIYADD------------------
19924_Tthe       RYKN------RELQMM---KEIGNHPNVIKLR-NHYYSYG-N------------------
2636_Tthe        KKLS------REYEIL---LDIKDCDYVVKMI-DLYYSKT--------------------
5825_Tthe        RYKN------REFEII---KSL-NHQNLIKLK-QAYYTTQNN------------------
7876_Tthe        RYKN------REREII---ERL-DHQNIIKCK-DFFETKGE-------------------
GSK3_Spur        RFKN------RELQIM---RRL-DHHNIVKLK-YFFYSSGE-------------------
n1163_Tthe       RYKN------REFEII---KSL-NHQNLIKLK-QAYYTTQNN----NVDSFFFHTFNSKI
CC1G_03802_Ccin  RFKN------RELQIM---RLV-SHPNVVDLK-AFFYSNGD-------------------
AqueK117_Aque    RFKQ--------------------------------------------------------
GSK_b_Smoe       RYKN------RELQIM---RLL-DHPSIVSLK-HCFFSTT--------------------
GSK_a-2_Smoe     RYKN------RELQIM---RLL-DHPNIVALK-HCFFSTT--------------------
GSK_a-1_Smoe     RYKN------RELQIM---RLL-DHPNIVALK-HCFFSTT--------------------
GK035_Glam       KYRN------RELSIM---QELGQHPCIIRLI-NSYISVATN------------------
GK036_Glam       RYKN------REFQIM---RTL-VHPCICRLVKGTFIPSIS-------------------


GSK3B_Hsap       ------------------------------------------------------------
GSK3A_Hsap       ------------------------------------------------------------
Pk34A_Dmel       ------------------------------------------------------------
sgg_Dmel         ------------------------------------------------------------
gskt_Dmel        ------------------------------------------------------------
GSK3B_Mmus       ------------------------------------------------------------
GSK3A_Mmus       ------------------------------------------------------------
R03D7.5_Cele     ------------------------------------------------------------
F21F3.2_Cele     ------------------------------------------------------------
C44H4.6_Cele     ------------------------------------------------------------
C36B1.10_Cele    ------------------------------------------------------------
RIM11_Scer       ------------------------------------------------------------
MRK1_Scer        ------------------------------------------------------------
MCK1_Scer        ------------------------------------------------------------
Y106G6D.4_Cele   ------------------------------------------------------------
Y106G6E.1_Cele   ------------------------------------------------------------
Y18D10A.5_Cele   ------------------------------------------------------------
YOL128C_Scer     ------------------------------------------------------------
GlkA_Ddis        ------------------------------------------------------------
GSK-3_Ddis       ------------------------------------------------------------
19912_Tthe       ------------------------------------------------------------
19923_Tthe       ------------------------------------------------------------
19924_Tthe       ------------------------------------------------------------
2636_Tthe        ------------------------------------------------------------
5825_Tthe        ------------------------------------------------------------
7876_Tthe        ------------------------------------------------------------
GSK3_Spur        ------------------------------------------------------------
n1163_Tthe       NSQLRFFLRYKKTQNCLHSLIQFTRYIQKHSKKSNTKTLIQIFNLRELDFPASHPVFYTN
CC1G_03802_Ccin  ------------------------------------------------------------
AqueK117_Aque    ------------------------------------------------------------
GSK_b_Smoe       ------------------------------------------------------------
GSK_a-2_Smoe     ------------------------------------------------------------
GSK_a-1_Smoe     ------------------------------------------------------------
GK035_Glam       ------------------------------------------------------------
GK036_Glam       ------------------------------------------------------------


GSK3B_Hsap       ----------KKDE--VY-LNLVLDYVPETVYRVARHYSR-------AKQTLPVIYVKLY
GSK3A_Hsap       ----------KKDE--LY-LNLVLEYVPETVYRVARHFTK-------AKLTIPILYVKVY
Pk34A_Dmel       ----------FPSV--DY-VLLVMEYMPMTLLDYINYHLTV------LQPAERLINVRIL
sgg_Dmel         ----------KRDE--VF-LNLVLEYIPETVYKVARQYAK-------TKQTIPINFIRLY
gskt_Dmel        ----------KRDE--VY-LNLVMEFLPETLYKVERQYAR-------AKQTLPVNFVRLY
GSK3B_Mmus       ----------KKDE--VY-LNLVLDYVPETVYRVARHYSR-------AKQTLPVIYVKLY
GSK3A_Mmus       ----------KKDE--LY-LNLVLEYVPETVYRVARHFTK-------AKLITPIIYIKVY
R03D7.5_Cele     -------------K--VI-NCLVLDYLPQDLARLRDQ-----------GVKFDVLDAKLY
F21F3.2_Cele     -------------K--VC-ESYVFDFMPNTLAEVIRQ-------------KLTDLDIRLY
C44H4.6_Cele     -----------QQE--NC-LNFVMEFMPKDLAYVHRQFAH-------NDKQMPAYSIKLY
C36B1.10_Cele    ----------HEGR--IC-LGLIFEYIPMNLHQFLKDNN----------RRVDIIEVKLI
RIM11_Scer       ----------SQDE--IY-LNLILEYMPQSLYQRLRHFVH-------QRTPMSRLEIKYY
MRK1_Scer        ----------EEDE--VY-LNLVLDYMPQSLYQRLRHFVN-------LKMQMPRVEIKFY
MCK1_Scer        ----------QDNK--VY-QHLAMECLPETLQIEINRYVT-------NKLEMPLKHIRLY
Y106G6D.4_Cele   ----------MKHS--FC-ESYVFGFMPYTLQNILKK------------TRLAEVDMKLY
Y106G6E.1_Cele   ----------HEGR--IC-LALIFEYIPLNLYQFLKDKN----------RRIDIVEVKLI
Y18D10A.5_Cele   ----------KKDE--LY-LNLILEYVPETVYRVARHYSK-------QRQQIPMIYVKLY
YOL128C_Scer     ----------TKDGGHLYQKNFVMEYIPQTLSSEIHEYFD-------NGSKMPTKHIKLY
GlkA_Ddis        ----------D-NK--KM-QNLVFDFIPYTLASLLK------------KRQLSINFIKVL
GSK-3_Ddis       ----------DNDE--VY-LNLVLEYVPDTVYRVSRHYSM-------SKQPVPNIFVKLY
19912_Tthe       ----------EEDD--VY-LNLIMEYVPSNLTKMIKYYHRKKLKQFEQREQFPNILIKLY
19923_Tthe       ----------KQED--VY-LNIIMDYIPETLYRMIKYFAKK------SKGNFPNILLKLY
19924_Tthe       ----------STDD--VY-LHLVMDFVPETLYKMIKYYSKK------HKGNFPNILLKYY
2636_Tthe        ----------DDNK--LI-QNIVFEYMENNLEDHISKFNK-------SKKVIPEQTVKEY
5825_Tthe        ----------NPDE--VY-LNIVMEYVPETLSKVIRTYRK-------SKQPFPPLLLKVF
7876_Tthe        ----------KKDE--VY-LNLVMEFMNFPLSKVIRDKRK-------ANQVMRIEDIRLY
GSK3_Spur        ----------KKDE--VF-LNLVLEYVPETVYRVARHYSK-------AKQTIANLYVKLY
n1163_Tthe       PILTRRYSTVIPDE--VY-LNIVMEYVPETLSKVIRTYRK-------SKQPFPPLLLKVF
CC1G_03802_Ccin  ----------KKDE--VY-LNLVLEYVPETVYRASRHYSK-------LKQPMPMLQIKLY
AqueK117_Aque    -----------KDE--VY-LNLVLDYIPDTVYRVIRHHYK-------AKQIMPMLFIKLY
GSK_b_Smoe       ----------DKDE--LY-LNLVLEYVPETVYRIAKHYNR-------MNQRMPLLYVKLY
GSK_a-2_Smoe     ----------DKDE--LY-LNLVLEYVPETVYRIAKHHNR-------MNQRMPLLYVKLY
GSK_a-1_Smoe     ----------DKDE--LY-LNLVLEYVPETVYRIAKHHNR-------MNQRMPLLYVKLY
GK035_Glam       ----------QTNG--DF-LNILMDYYQENGYQIYKSYIR-------AGIKMPMFHIKLY
GK036_Glam       ----------SPDD--LI-LYLLMDYYPETIHSIYRQYSR-------LRQHVPLLIVRLI
                                        :                                 :

GSK3B_Hsap       MYQLFRSLAYIHS-FGICHRDIKPQNLLLDPD--TAVLKLCDFGSAKQLVRG--------
GSK3A_Hsap       MYQLFRSLAYIHS-QGVCHRDIKPQNLLVDPD--TAVLKLCDFGSAKQLVRG--------
Pk34A_Dmel       SYQMFRGLGYLHL-LGISHRDVKPENLLIDNQ--KMVLKLSDFGSAKLLVPQ--------
sgg_Dmel         MYQLFRSLAYIHS-LGICHRDIKPQNLLLDPE--TAVLKLCDFGSAKQLLHG--------
gskt_Dmel        MYQLLRSMGYLHS-LGFCHRDIKPQNMLLDSE--TGVLKLCDFGSAKQLISG--------
GSK3B_Mmus       MYQLFRSLAYIHS-FGICHRDIKPQNLLLDPD--TAVLKLCDFGSAKQLVRG--------
GSK3A_Mmus       MYQLFRSLAYIHS-QGVCHRDIKPQNLLVDPD--TAVLKLCDFGSAKQLVRG--------
R03D7.5_Cele     TFQLFCAISHLTS-KNIVHMDIKPQNVVMDRM--AGRLKLADFGNARRLETN--------
F21F3.2_Cele     TWQIFSGLKYLEE-HKVVHRDLKPVNILVDHD--TAFLKISDFGSAKIIVKG--------
C44H4.6_Cele     MFQLLRGIGFLHL-HNIVHRDIKPKNLLVDES--NGILKICDFGSAKRLEKN--------
C36B1.10_Cele    VWQLFRGQAHLEK-SEICHRDIKPQNLLYNAD--TGLLKISDYGSSAIESVK--------
RIM11_Scer       MFQLFKSLNYLHHFANVCHRDIKPQNLLVDPE--TWSLKLCDFGSAKQLKPT--------
MRK1_Scer        AYQLFKALNYLHNVPRICHRDIKPQNLLVDPT--TFSFKICDFGSAKCLKPD--------
MCK1_Scer        TYQIARGMLYLHG-LGVCHRDIKPSNVLVDPE--TGVLKICDFGSAKKLEHN--------
Y106G6D.4_Cele   TWQLFEGIRYLQA-HMIVHRDIKPVNILVDVD--KGTLKIADFGSAKVVLRG--------
Y106G6E.1_Cele   VWQLFRGQAHLEK-ADICHRDIKPQNLLYNAE--TGLLKISDFGSSSIQSTK--------
Y18D10A.5_Cele   MYQLLRSLAYIHS-IGICHRDIKPQNLLIDPE--SGVLKLCDFGSAKYLVRN--------
YOL128C_Scer     TFQILRALLTLHS-MSICHGDLKPSNILIIPS--SGIAKVCDFGSAQRLDDN--------
GlkA_Ddis        FYQLCQAIKHIHS-KAICHRDITPNNILLSS---KGELTLADFGSAKILESN--------
GSK-3_Ddis       IYQLCRSINYIHS-LGICHRDIKPQNLLLDTS--TSTLKLCDFGSAKILIKG--------
19912_Tthe       LYQAFRALAYLNG-LNIAHRDIKPSNILINHR--THQLKFCDFGSAKKLSRG--------
19923_Tthe       SYQLMRSLAYIQG-LGICHRDIKPTNVLVDPR--NHALKMCDFGSAKKLNPS--------
19924_Tthe       SYQMLRSLAYIHG-INICHRDIKPQNILVDPR--NHNLKMCDFGSAKKLVPG--------
2636_Tthe        AYQILKGLQYIHS-KGIAHRDLKPDNILLND---DGKVKICDFGGSKYIDEK--------
5825_Tthe        SYQMFRALAYLKG-IGICHRDIKPQNILCDQK--TMQLKICDFGSAKKLIKG--------
7876_Tthe        AYQMFKALSYLQS-LNICHRDIKPQNILVNDKDDDKRLKICDFGSAKQLIPN--------
GSK3_Spur        MYQLFRSLAYIHS-MGICHRDIKPQNLLLNPE--TAVLKLCDFGSAKVLVRG--------
n1163_Tthe       SYQMFRALAYLKG-IGICHRDIKPQNILCDQK--TMQLKICDFGSAKKLIKGKLDILFVS
CC1G_03802_Ccin  MYQLLRSLAYIHS-VGICHRDIKPQNLLLNPS--TGVLKLCDFGSAKILVAG--------
AqueK117_Aque    MYQLFRALGYIHA-NGVCHRDIKPQNLLLNPE--TGVLKLCDFGSAKVLVRG--------
GSK_b_Smoe       TYQICRALTYIHGGMGVCHRDIKPQNLLVNPH--THQLKLCDFGSAKVLVKG--------
GSK_a-2_Smoe     TYQICRSLAYIHGGIGVCHRDIKPQNLLVNPH--THQLKLCDFGSAKVLVKG--------
GSK_a-1_Smoe     TYQICRSLAYIHGGIGVCHRDIKPQNLLVNPH--THQLKLCDFGSAKVLVKG--------
GK035_Glam       TFQFLRGLAYMHS-FNIANRDLKPQNTLVNRE--SGRAVLCDLGSAKKLNPA--------
GK036_Glam       TYQLARSLAYLHY-HNIAHRDCKPTNVLIDPL--TYRCVLCDFGSAKQLVPQ--------
                  :*   .   :     . : * .* * :           ..* *.:

GSK3B_Hsap       ------------------------------------------------------EP-NVS
GSK3A_Hsap       ------------------------------------------------------EP-NVS
Pk34A_Dmel       ------------------------------------------------------EP-SIS
sgg_Dmel         ------------------------------------------------------EP-NVS
gskt_Dmel        ------------------------------------------------------EP-NVS
GSK3B_Mmus       ------------------------------------------------------EP-NVS
GSK3A_Mmus       ------------------------------------------------------EP-NVS
R03D7.5_Cele     ------------------------------------------------------EKTGSA
F21F3.2_Cele     ------------------------------------------------------KA-NNF
C44H4.6_Cele     ------------------------------------------------------EP-NIT
C36B1.10_Cele    ------------------------------------------------------TP-QQS
RIM11_Scer       ------------------------------------------------------EP-NVS
MRK1_Scer        ------------------------------------------------------QP-NVS
MCK1_Scer        ------------------------------------------------------QP-SIS
Y106G6D.4_Cele   ------------------------------------------------------SS-STS
Y106G6E.1_Cele   ------------------------------------------------------SP-QQS
Y18D10A.5_Cele   ------------------------------------------------------EP-NVS
YOL128C_Scer     ------------------------------------------------------TE-LKT
GlkA_Ddis        ------------------------------------------------------HT-SMS
GSK-3_Ddis       ------------------------------------------------------ET-NVS
19912_Tthe       ------------------------------------------------------ES-NIS
19923_Tthe       ------------------------------------------------------ET-NIS
19924_Tthe       ------------------------------------------------------ES-NIS
2636_Tthe        ------------------------------------------------------GK-NTP
5825_Tthe        ------------------------------------------------------EP-NVS
7876_Tthe        ------------------------------------------------------EA-NIS
GSK3_Spur        ------------------------------------------------------EP-NVS
n1163_Tthe       YSSVVSKNLVFILISSLTAKKQIDYQQFLFKSNKKPKQLLNIQTAPFNKHQKQSEP-NVS
CC1G_03802_Ccin  ------------------------------------------------------EP-NVS
AqueK117_Aque    ------------------------------------------------------EP-NVS
GSK_b_Smoe       ------------------------------------------------------EP-NIS
GSK_a-2_Smoe     ------------------------------------------------------EP-NIS
GSK_a-1_Smoe     ------------------------------------------------------EP-NIS
GK035_Glam       ------------------------------------------------------EP-NIA
GK036_Glam       ------------------------------------------------------EN-NVA


GSK3B_Hsap       YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD-SGVDQLVEIIKVLG
GSK3A_Hsap       YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD-SGVDQLVEIIKVLG
Pk34A_Dmel       YICSRLYRAPELFAGYELYSCAVDIWSAGCVLAELLKGYPLFSSHKHDRKQLRLIVNMLG
sgg_Dmel         YICSRYYRAPELIFGAINYTTKIDVWSAGCVLAELLLGQPIFPGD-SGVDQLVEVIKVLG
gskt_Dmel        YICSRYYRAPELIFGSTDYTTKIDMWSAGCVMSELLLGQLIFPGD-SGVDQIVEIVKVMG
GSK3B_Mmus       YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD-SGVDQLVEIIKVLG
GSK3A_Mmus       YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD-SGVDQLVEIIKVLG
R03D7.5_Cele     YQVTRFYRPPELLFGCEKFTASIDIWSATCVAFELFANRVLFKGK-DTKDQIVLITGVFG
F21F3.2_Cele     YQVTRFYRPPELLMKAMEYNSTVDVWSAGCIMAEMVKRHVVFPGR-DSAHQLKLYCRCFG
C44H4.6_Cele     YICSRYYRAPELIFGSKNYDTSIDTWSVGTVVGELLHNSPIFLAD-SAVDILALQIKAFG
C36B1.10_Cele    YHVTRYYRPPELLLGSKNYGCKIDTWSCGCVFGELLKGGIFLAGK-SAKNQAEVVFDMFG
RIM11_Scer       YICSRYYRAPELIFGATNYTNQIDIWSSGCVMAELLLGQPMFPGE-SGIDQLVEIIKILG
MRK1_Scer        YICSRYYRAPELMFGATNYSNQVDVWSSACVIAELLLGKPLFSGE-SGIDQLVEIIKIMG
MCK1_Scer        YICSRFYRAPELIIGCTQYTTQIDIWGLGCVMGEMLIGKAIFQGQ-EPLLQLREIAKLLG
Y106G6D.4_Cele   YQVTRFYRPPELLLDAKEYYWMVDVWSAGCCVGEMMKGKVLFPGA-SIKIMLKLIVQAIG
Y106G6E.1_Cele   YHVTRYYRPPELILGSKYYGCKIDTWSCGCVFGELLKGGIILAGK-SSNNQAEVIFDMLG
Y18D10A.5_Cele   YICSRYYRAPELIFGATNYTNSIDVWSAGTVMAELLLGQPIFPGD-SGVDQLVEIIKVLG
YOL128C_Scer     YFCSRFYRAPELLLNSKDYTTQIDIWSLGCIIGEMIKGQPLFKGD-SANSQLEEIAKLLG
GlkA_Ddis        YICSRYYRAPELLVGCSNYTTKIDIWSIGCILAEMLIGKPLFPGT-NSNDQLGRIIEVLG
GSK-3_Ddis       YICSRHYRAPELIFGSTNYTTTIDVWSLGCVLAELLLGQPLFPGE-NGIDQLVEIIKVLG
19912_Tthe       YICSRFYRAPELMLGASNYTTSVDVWSLGCVVAEMLLGEPLFKGN-SSLDQLVEVMKVLG
19923_Tthe       YICSRYYRAPELMFMATQYTNSIDVWSVGCVIAEMVLGDPIFAGE-SSVDQLIEIIKILG
19924_Tthe       YICSRCYRAPELMFQATQYTHAIDVWSVGCVIAEMVLGQPIFIGE-SSVDQLIEIIKVLG
2636_Tthe        YIVSRYYRAPELILCITKYNQKIDMWSFGCILGELVTTFPLFQGK-TEGDQLFSIFKVLG
5825_Tthe        YICSRYYRAPELIFGAEQYTTAIDTWSIGTVIAEMILGEPLFPGE-NAVEQLVEIIKILG
7876_Tthe        YICSRYYRAPELIFKSQHYTNAIDMWSMGCVIAEMVLGEPLFPGE-NSLDQLVEIIRILG
GSK3_Spur        YICSRYYRAPELIFGATDYTCDIDVWSAGCVLAELLLGQPIFPGD-SGVDQLVEIIKVLG
n1163_Tthe       YICSRYYRAPELIFGAEQYTTAIDTWSIGTVIAEMILGEPLFPGE-NAVEQLVEIIKILG
CC1G_03802_Ccin  YICSRYYRAPELIFGATNYTTNIDIWSTGCVMAELMLGQPLFPGE-SGIDQLVEIIKVLG
AqueK117_Aque    YICSRYYRAPELIFGATDYTVNIDIWSAGCVFAELLLGQPIFPGD-SGVDQLVEIIKILG
GSK_b_Smoe       YICSRYYRAPELIFGATDYTTAIDIWSTGCVLAELLLGQPLFPGE-SGVDQLVEIIKVLG
GSK_a-2_Smoe     YICSRYYRAPELIFGATEYTTAIDIWSMGCVLAELLLGQPLFPGE-SGVDQLVEIIKVLG
GSK_a-1_Smoe     YICSRYYRAPELIFGATEYTTAIDIWSMGCVLAELLLGQPLFPGE-SGVDQLVEIIKVLG
GK035_Glam       YICSRYYRAPELIFGSRYYTTVIDIWSFGCVVAEMIIGKPIYAGS-SPLDQIIEIIKILG
GK036_Glam       YICSRFYRAPELVIGNQNYTCAIDIWSFGCIMAEILLGQPLFPGD-SSIDQLVEIVRVLG
                 *  :* **.***.     :   :* *.      *:.    .  .              :*

GSK3B_Hsap       TPTREQIREMNPNYT--EFKF------------------------PQ------IKA----
GSK3A_Hsap       TPTREQIREMNPNYT--EFKF------------------------PQ------IKA----
Pk34A_Dmel       TDGLERAPEILSKCG--NSLH------------------------PR------TTR----
sgg_Dmel         TPTREQIREMNPNYT--EFKF------------------------PQ------IKS----
gskt_Dmel        TPTSEQLHDMNPHYK--QFKL------------------------PE------LKP----
GSK3B_Mmus       TPTREQIREMNPNYT--EFKF------------------------PQ------IKA----
GSK3A_Mmus       TPTREQIREMNPNYT--EFKF------------------------PQ------IKA----
R03D7.5_Cele     YPTDDDIKSIGVKRP--RVARKDARGIETVKIKEKTNKTKKEAKQSTLVHEKYTRARAMS
F21F3.2_Cele     APNEQDISAMKGEKL--EKEYWKF-----------------------------TKG----
C44H4.6_Cele     TPSKEDMAKWNYEYV--HIPY------------------------DT------ITG----
C36B1.10_Cele    VPTAEDVSSMNVSNT--KYKE-------------------------I------IQS----
RIM11_Scer       TPSKQEICSMNPNYM--EHKF------------------------PQ------IKP----
MRK1_Scer        IPTKDEISGMNPNYE--DHVF------------------------PN------IKP----
MCK1_Scer        PPDKRFIFFSNPAYD--GPLFSK---P----------------LFSG------SSQ----
Y106G6D.4_Cele   LPSARDLDYMKVSSM--IDQQSA------------------------------VKV----
Y106G6E.1_Cele   YPTDSDVSSMKVSST--KLQE-------------------------V------LDS----
Y18D10A.5_Cele   TPTREQIQSMNPNYK--EFKF------------------------PQ------IKA----
YOL128C_Scer     RFPKSSIKNSQELQ----DSLND---Q----------------KFK--------------
GlkA_Ddis        SPTKDDMEAMKPSKP--YHL-----------------------QLPN------INP----
GSK-3_Ddis       TPTKEQIHAMNPYYT--SFKF------------------------PE------IKA----
19912_Tthe       APSPEQIREMNPEHK--LLKY------------------------PP------INK----
19923_Tthe       TPTLQQ--HMNPDHQ--PTQM------------------------PK------IKP----
19924_Tthe       TPTQQQIFAMNPDHQ--GTKM------------------------PN------IKP----
2636_Tthe        SPTKEEFQKFSERVPFDKKIFD---------------------EFQT------YEP----
5825_Tthe        TPTKEQVQKMNPQHN--QFNF------------------------PS------IKP----
7876_Tthe        TPTRQQILMMNPTSQ--EFRF------------------------PQ------IKS----
GSK3_Spur        TPSRDQIKEMNPNYT--EFKF------------------------PQ------IKP----
n1163_Tthe       TPTKEQVQKMNPQHN--QFNF------------------------PS------IKP----
CC1G_03802_Ccin  TPSREQIKTMNPNYM--EHKF------------------------PQ------IKP----
AqueK117_Aque    TPTKEQIRQMNPNYT--EFKF------------------------PQ------IKA----
GSK_b_Smoe       TPTREEIKCMNPNYT--EFKF------------------------PQ------IKA----
GSK_a-2_Smoe     TPTREEIKCMNPNYT--EFKF------------------------PQ------IKA----
GSK_a-1_Smoe     TPTREEIKCMNPNYT--EFKF------------------------PQ------IKA----
GK035_Glam       PPSLKELKEMNPTLK--EYAF------------------------PT------IRT----
GK036_Glam       SPTAEEFLAMNPTLK--SVKF------------------------KD------VKR----


GSK3B_Hsap       ----HP----------------------------WTKDSSGTGHFTSGVRVFR-------
GSK3A_Hsap       ----HP----------------------------WTK-------------VFK-------
Pk34A_Dmel       ----PS----------------------------WNY-------------LLN-------
sgg_Dmel         ----HP----------------------------WQK-------------VFR-------
gskt_Dmel        ----HP----------------------------WSK-------------VFR-------
GSK3B_Mmus       ----HP----------------------------WTKDSPGAGHFTPGVRVFR-------
GSK3A_Mmus       ----HP----------------------------WTK-------------VFK-------
R03D7.5_Cele     RSTENK----------------------------LAP-------------FTS-------
F21F3.2_Cele     ----FG----------------------------LQR-------------LVN-------
C44H4.6_Cele     ----VG----------------------------IQK-------------FIG-------
C36B1.10_Cele    ----YEPDTSKRTADLAYLYNQTASFQRDRRSTVYNT-------------KID-------
RIM11_Scer       ----IP----------------------------LSR-------------VFK-------
MRK1_Scer        ----IT----------------------------LAE-------------IFK-------
MCK1_Scer        ----QR----------------------------FEK-------------YFG-------
Y106G6D.4_Cele   ----IG----------------------------LKE-------------VLG-------
Y106G6E.1_Cele   ----YEYNKSKTTADLTYLYTQTVIYQKDRRTTVYNT-------------KIE-------
Y18D10A.5_Cele   ----HP----------------------------WNK-------------VFR-------
YOL128C_Scer     -----K----------------------------FMH-------------WFP-------
GlkA_Ddis        ----KF----------------------------FES--------------LH-------
GSK-3_Ddis       ----NP----------------------------WPR-------------VFK-------
19912_Tthe       ----MP----------------------------LSK-------------ICQ-------
19923_Tthe       ----TP----------------------------WSK-------------VFK-------
19924_Tthe       ----TP----------------------------WTK-------------VFQ-------
2636_Tthe        ----QN----------------------------LRK-------------MFF-------
5825_Tthe        ----TS----------------------------WTK-------------IF--------
7876_Tthe        ----YS----------------------------WSK-------------VFEKSLQ---
GSK3_Spur        ----HP----------------------------WNK-------------VFR-------
n1163_Tthe       ----TS----------------------------WTK-------------LIKQISTVIN
CC1G_03802_Ccin  ----HP----------------------------FSK-------------VFR-------
AqueK117_Aque    ----HA----------------------------WNK-------------VFR-------
GSK_b_Smoe       ----HP----------------------------WHK-------------VFH-------
GSK_a-2_Smoe     ----HP----------------------------WHK-------------VFH-------
GSK_a-1_Smoe     ----HP----------------------------WHK-------------VFH-------
GK035_Glam       ----TP----------------------------MSD-------------VLG-------
GK036_Glam       ----YP----------------------------FSK-------------IFR-------


GSK3B_Hsap       ----------------P-RTPP--EAIALCSRLLEYTPTARLTPLEACAHSFFDELRD-P
GSK3A_Hsap       ----------------S-RTPP--EAIALCSSLLEYTPSSRLSPLEACAHSFFDELRC-L
Pk34A_Dmel       ----------------T-AVPQ--DLCGLLNSCFIYEAAARISPMMACSHGSYDELRI-M
sgg_Dmel         ----------------I-RTPT--EAINLVSLLLEYTPSARITPLKACAHPFFDELRM-E
gskt_Dmel        ----------------I-RTPA--EAIDLVSKMLIYSPNARVSPLMGCAHPFFDELRQDP
GSK3B_Mmus       ----------------P-RTPP--EAIALCSRLLEYTPTARLTPLEACAHSFFDELRD-P
GSK3A_Mmus       ----------------SSKTPP--EAIALCSSLLEYTPSSRLSPLEACAHSFFDELRR-L
R03D7.5_Cele     -----------------KMLDS--EIYDFMKATLKIDPKKRKSAIDVLKMPLFDILRS-S
F21F3.2_Cele     -----------------D-ISP--DQLQFIKRILVYAPEKRLRGKQLLQDDFFRPLFK-A
C44H4.6_Cele     ----------------R-KLSL--STLELLNSLMKMDPKLRIKPYEALTLPYFDDLRD-P
C36B1.10_Cele    ----------------Y-SDMK--DSVELLRQVLVYNPSRRLCGIEFLTNPFFTVLFN-E
RIM11_Scer       ----------------K-E-DD--QTVEFLADVLKYDPLERFNALQCLCSPYFDELKL-D
MRK1_Scer        ----------------A-E-DP--DTLDLLTKTLKYHPCERLVPLQCLLSSYFDETKR-C
MCK1_Scer        -----------------H-SGP--DGIDLLMKILVYEPQQRLSPRRILAHQFFNELRN-D
Y106G6D.4_Cele   -----------------T-ENQ--EWADFLGAILRYRPRERLHGPKLLSHPFFDLIFT-P
Y106G6E.1_Cele   ----------------Q-DDMK--ESVAVLLQILVYNPNKRLSGIEILTHPYFNVLFN-E
Y18D10A.5_Cele   ----------------V-HTPA--EAIDLISKIIEYTPTSRPTPQAACQHAFFDELRN-P
YOL128C_Scer     -----------------S-IEF--FDVEFLLKVLTYDATERCDARQLMAHEFFDALRN-E
GlkA_Ddis        ----------------NV-EDK--TVVDLLSKIFIFDPVKRASIDEIIAHPFLRDVNIN-
GSK-3_Ddis       ----------------AKDVPA--ESIDLISKILLYDPSSRLKPVEICAHPFFDELRD-P
19912_Tthe       ----------------N-KCQSMNHLKGLSLQKLYYIPILMN-----------------Q
19923_Tthe       ----------------NCKVDP--LAIDLISKVLVYSPQLRLKPLEALAHPFFDELRN-P
19924_Tthe       ----------------NCRIDP--LAIDLISKILVYNPEKRLKPLEALLHPFFEELRN-P
2636_Tthe        ----------------YIKDID--NLMDLITKCLQYLPENRITADEALQHPFFKGLEE--
5825_Tthe        ---------------AKQKPDP--MLIDLISRLLVFVPTDRPTPLETLLHPYFNELRS-E
7876_Tthe        -----------KVSEDEKQKFN--QLMDLISRVLVYAPSERPSPLQALAHPFFDELRI-E
GSK3_Spur        ----------------A-RTPA--DAIQLCSRLLEYTPKSRIKPLEACAHQFFSELRE-P
n1163_Tthe       KYSNKKQQQNANIF-AKQKPDP--MLIDLISRLLVFVPTDRPTPLETLLHPYFNELRS-E
CC1G_03802_Ccin  ----------------P-RTAP--EAIDLVSKLLEYTPGARLSAVEAMVHPFFDELRA-E
AqueK117_Aque    ----------------P-RTPP--EAIDLVSRLLEYTPTMRITTLDSCAHSFFDELRQ-P
GSK_b_Smoe       ----------------K-RMPP--EAVDLVSRLLQYSPSLRCNALEALVHPFFDELRD-P
GSK_a-2_Smoe     ----------------K-RMPP--EAVDLVSRLLQYSPNLRCSSLEALAHPFFDELRD-P
GSK_a-1_Smoe     ----------------K-RMPP--EAVDLVSRLLQYSPNLRCSSLEALAHPFFDELRD-P
GK035_Glam       ----------------T-K-DP--VVLDFFARCFKYSPNERITAYEALAHPFYDDLRA-R
GK036_Glam       ----------------S-KAHT--DAVDLLTKVLVYDPKKRPTAMEILAHPFYDILRD-P
                                             .    :   .

GSK3B_Hsap       N---VKLPNGRD----TPA-LFNFTTQ-ELS---------S-N--PP------LAT----
GSK3A_Hsap       G---TQLPNNRP----LPP-LFNFSAG-ELS---------I-Q--PS------LNA----
Pk34A_Dmel       DAMALPMPNGNP----LPP-LFDFNSL-EMG---------T-D--PK------LWV----
sgg_Dmel         GN--HTLPNGRD----MPP-LFNFTEH-ELS---------I-Q--PS------LVP----
gskt_Dmel        H---QQLPNGRS----LPP-LFNFTDY-EKT---------I-E--PD------TMP----
GSK3B_Mmus       N---VKLPNGRD----TPA-LFNFTTQ-ELS---------S-N--PP------LAT----
GSK3A_Mmus       G---AQLPNDRP----LPP-LFNFSPG-ELS---------I-Q--PS------LNA----
R03D7.5_Cele     PP--KKRSNGVE----MPN-LASYTEM-HHK---------R-E--PE------T------
F21F3.2_Cele     G---AVRHNGQK----ISD-VITAADY-KRA---------A-E--NEESSACRLAQLVKT
C44H4.6_Cele     H---YKLPSGAP----IPP-LFDWLER-EYI---------A-N--HE------IIK----
C36B1.10_Cele    KT---VRFNKKK----IQC-VSAVDLQ-AVK-----------------------------
RIM11_Scer       D---GKINQITT----DLK-LLEFDENVEL---------GH-L-----------------
MRK1_Scer        D---TDTYVKAQ----NLR-IFDFDVETEL---------GH-V--PL------VER----
MCK1_Scer        D---TFLPRGFTEPIKLPN-LFDFNDF-ELQ---------I-L--GE------FAD----
Y106G6D.4_Cele   K---CTLSNGLL----VSQ-VITLDDY-KTA---------Q-K--NDSTSGKQYAAAILR
Y106G6E.1_Cele   KT---VRFNKKK----ILC-LSAVDLQ-SVK-----------------------------
Y18D10A.5_Cele   D---ARLPSGRP----LPT-LEMDGPM-GTG-----------------------------
YOL128C_Scer     T---YFLPRGSSMPVHLPD-LFNFSAS-EKR---------A-L--GE------YYN----
GlkA_Ddis        S---LELFDE----M---K-CFSVSGN-GKS--------SL-TTNST------SSS----
GSK-3_Ddis       K---TCLPDGKP----LPP-LFNFTIA-EQT--------SI-G--PK------LAK----
19912_Tthe       -E--QSI-AGQM----ER-DFHLYST-F---------Q----------------------
19923_Tthe       L---CRI-NGQK----LPE-LFNFTQI-IIQILFKLVEVNGYP--DE------LIN----
19924_Tthe       K---CRI-NGKP----LDN-LFNFTEA-EIG---------P-N--EE------LLQ----
2636_Tthe        ------------------------------------------------------------
5825_Tthe        K---FYE-QYTK----QID-LFNFSPE-E---------LKS-Q--PQ------LAS----
7876_Tthe        E---KKY-RQT-----QLY-LFDFPEA-KE--------QEY-Q--KQ------IEQ----
GSK3_Spur        G---TKLPNGRE----LPP-LFNFSAS-ELV---------S-K--PS------LRT----
n1163_Tthe       K---FYE-QYTK----QID-LFNFSPE-E---------LKS-Q--PQ------LAS----
CC1G_03802_Ccin  G---AKMPNGKE----FPR-LFDFTRE-ELS---------V-R--PD------LIR----
AqueK117_Aque    G---ANMPNGRD----FPP-LFNFSQQ-ELS---------I-C--PS------LES----
GSK_b_Smoe       S---TRLPNGRP----LPA-LFNFKPL-ELK--------GA-S--QE------LLE----
GSK_a-2_Smoe     N---TRLPNGRP----LPP-LYNFKQL-ELK--------GA-S--PE------LLN----
GSK_a-1_Smoe     N---TRLPNGRP----LPP-LYNFKQL-ELK--------GA-S--PE------LLN----
GK035_Glam       D---API--SKD----L-K-LFEFSEY-ERK--------AM-S--PE------LLS----
GK036_Glam       D---TLLPNGER----LPAFLFEFTEE-ERK--------AA-G--PE------LMA----


GSK3B_Hsap       ------------------------ILI-PPHA----------------------------
GSK3A_Hsap       ------------------------ILI-PPHL----------------------------
Pk34A_Dmel       ------------------------NLL-PIHL----------------------------
sgg_Dmel         ------------------------QLL-PKHL----------------------------
gskt_Dmel        ------------------------LLL-PRAQ----------------------------
GSK3B_Mmus       ------------------------ILI-PPHA----------------------------
GSK3A_Mmus       ------------------------ILI-PPHL----------------------------
R03D7.5_Cele     ------------------------EVV-ADIQ----------------------------
F21F3.2_Cele     DNKDLGIPYCEKSNSYENVYARRSTLI-PKEQ----------------------------
C44H4.6_Cele     ------------------------DIF-PRSE----------------------------
C36B1.10_Cele    ------------------------------------------------------------
RIM11_Scer       --------------------------S-PDEL----------------------------
MRK1_Scer        ------------------------PAI-EERL----------------------------
MCK1_Scer        ------------------------KIK-P-------------------------------
Y106G6D.4_Cele   HEIRF---------------SLKAPIVHPPAPPAPPVVPMIDMISCRFLIFLSLLVTVFS
Y106G6E.1_Cele   ------------------------------------------------------------
Y18D10A.5_Cele   ------------------------------------------------------------
YOL128C_Scer     ------------------------LIV-P-------------------------------
GlkA_Ddis        ------------------------STT-AN-M----------------------------
GSK-3_Ddis       ------------------------TLI-PSHA----------------------------
19912_Tthe       -----------------------KLLT-PKWY----------------------------
19923_Tthe       ------------------------KLI-PDWY----------------------------
19924_Tthe       ------------------------RLI-PDWY----------------------------
2636_Tthe        ------------------------------------------------------------
5825_Tthe        ------------------------QLI-PQWY----------------------------
7876_Tthe        -----------------------LKLI-PNGY----------------------------
GSK3_Spur        ------------------------VLI-PPHA----------------------------
n1163_Tthe       ------------------------QLI-PQWY----------------------------
CC1G_03802_Ccin  ------------------------KLV-PPHA----------------------------
AqueK117_Aque    ------------------------KLV-PPHY----------------------------
GSK_b_Smoe       ------------------------RLI-PEHA----------------------------
GSK_a-2_Smoe     ------------------------RLV-PEHA----------------------------
GSK_a-1_Smoe     ------------------------RLV-PEHA----------------------------
GK035_Glam       ------------------------KIR---------------------------------
GK036_Glam       ------------------------VLT-KNR-----------------------------


GSK3B_Hsap       ----------RIQAAAS-T------------P-----------------T----------
GSK3A_Hsap       ----------RSPAGTT-T------------L----------------------------
Pk34A_Dmel       ----------SSM-----------------------------------------------
sgg_Dmel         ----------QNASGPG-G------------NRPSAGGAASIAASGSTSV----------
gskt_Dmel        ----------GSSTTKEPS------------A-----------------A--HRNRNTAG
GSK3B_Mmus       ----------RIQAAAS-P------------P-----------------A----------
GSK3A_Mmus       ----------RSPAGPA-S------------P-----------------L----------
R03D7.5_Cele     ------------------------------------------------------------
F21F3.2_Cele     ----------KMARDNK-S------------K-----------------EDSS-------
C44H4.6_Cele     ------------------------------------------------------------
C36B1.10_Cele    -----------SG-----------------------------------------------
RIM11_Scer       ----------S-------------------------------------------------
MRK1_Scer        ----------K-------------------------------------------------
MCK1_Scer        ------------------------------------------------------------
Y106G6D.4_Cele   LECYTGFTYLKAQSVGT-S------------K-----------------ETCP-------
Y106G6E.1_Cele   -----------SG-----------------------------------------------
Y18D10A.5_Cele   ------------------------------------------------------------
YOL128C_Scer     ------------------------------------------------------------
GlkA_Ddis        ----------TSLASSS-SNNKTTCSETYLSR----------------------------
GSK-3_Ddis       ----------MNQIELP-S------------P-----------------L----------
19912_Tthe       ----------QLLKQ---------------------------------------------
19923_Tthe       ----------SQMCAGV-------------------------------------------
19924_Tthe       ----------VQQL----------------------------------------------
2636_Tthe        ------------------------------------------------------------
5825_Tthe        ----------TSRREKE-S------------KL----------------I----NNSKQA
7876_Tthe        ------------------------------------------------------------
GSK3_Spur        ----------SHSQNSS-S------------T-----------------T----------
n1163_Tthe       ----------TSRREKE-S------------KL----------------I----NNSKQA
CC1G_03802_Ccin  ----------EPELASR-S------------I-----------------A----------
AqueK117_Aque    ----------HESLSSG-S------------SG----------------P----------
GSK_b_Smoe       ----------RKQ-----------------------------------------------
GSK_a-2_Smoe     ----------RKQ-----------------------------------------------
GSK_a-1_Smoe     ----------RKQ-----------------------------------------------
GK035_Glam       ------------------------------------------------------------
GK036_Glam       ------------------------------------------------------------


GSK3B_Hsap       ----------------------------------------------------NA-----T
GSK3A_Hsap       --------------------------------------------------TPSS-----Q
Pk34A_Dmel       ------------------------------------------------------------
sgg_Dmel         -------------------------------------SSTGSGASVEGSAQPQS-----Q
gskt_Dmel        E-ESPRKTED--------------------------------------SQKPAT-----A
GSK3B_Mmus       ----------------------------------------------------NA-----T
GSK3A_Mmus       ----------------------------------------------TTSYNPSS-----Q
R03D7.5_Cele     ------------------------------------------------------------
F21F3.2_Cele     --------------------------------------------------DDRR------
C44H4.6_Cele     ------------------------------------------------------------
C36B1.10_Cele    ------------------------------------------------------------
RIM11_Scer       ------------------------------------------------------------
MRK1_Scer        ------------------------------------------------------------
MCK1_Scer        ------------------------------------------------------------
Y106G6D.4_Cele   --------------------------------------------------SPND-----Y
Y106G6E.1_Cele   ------------------------------------------------------------
Y18D10A.5_Cele   ------------------------------------------------------------
YOL128C_Scer     ------------------------------------------------------------
GlkA_Ddis        --------------------------------------------------LPTS------
GSK-3_Ddis       ---------FPNLAISSSNQS-SSSNSNANVSSNLNSHSASPSTTSSSSSTPNSIPVQSP
19912_Tthe       ------------------------------------------------------------
19923_Tthe       ------------------------------------------------------------
19924_Tthe       ------------------------------------------------------------
2636_Tthe        ------------------------------------------------------------
5825_Tthe        EQQQSQL--VNQLT-NEFNQKMDISNSQ----KNING-----------------------
7876_Tthe        ------------------------------------------------------------
GSK3_Spur        --------------------------------------------------VPH-------
n1163_Tthe       EQQQSQL--VNQLT-NEFNQKMDISNSQ----KNING-----------------------
CC1G_03802_Ccin  ------------------------------------------------------------
AqueK117_Aque    --------------------------------------------------PPQG-----H
GSK_b_Smoe       ------------------------------------------------------------
GSK_a-2_Smoe     ------------------------------------------------------------
GSK_a-1_Smoe     ------------------------------------------------------------
GK035_Glam       ------------------------------------------------------------
GK036_Glam       ------------------------------------------------------------


GSK3B_Hsap       ---AA---SDAN------------------------------------------------
GSK3A_Hsap       ---AL---TETP------------------------------------------------
Pk34A_Dmel       ------------------------------------------------------------
sgg_Dmel         ---GTA--AAAG----------------SGSGGATAGTGGASAGGPGSGNNSSSGGASGA
gskt_Dmel        ---AL---SKSPGPSGKALESPPGFLQHDLGNGDHVAVGTMPMEPLTLEQNHFAAESYAV
GSK3B_Mmus       ---AA---SDTN------------------------------------------------
GSK3A_Mmus       ---AL---TEAQ------------------------------------------------
R03D7.5_Cele     ------------------------------------------------------------
F21F3.2_Cele     VAPSS---GEAP------------------------------------------------
C44H4.6_Cele     ------------------------------------------------------------
C36B1.10_Cele    ------------------------------------------------------------
RIM11_Scer       ------------------------------------------------------------
MRK1_Scer        ------------------------------------------------------------
MCK1_Scer        ------------------------------------------------------------
Y106G6D.4_Cele   CYNMT---ADLT------------------------------------------------
Y106G6E.1_Cele   ------------------------------------------------------------
Y18D10A.5_Cele   ------------------------------------------------------------
YOL128C_Scer     ------------------------------------------------------------
GlkA_Ddis        ---AITSSSNLK------------------------------------------------
GSK-3_Ddis       ---ST---TNTT------------------------------------------------
19912_Tthe       ------------------------------------------------------------
19923_Tthe       ------------------------------------------------------------
19924_Tthe       ------------------------------------------------------------
2636_Tthe        ------------------------------------------------------------
5825_Tthe        -------------NFG--------------------------------------------
7876_Tthe        ------------------------------------------------------------
GSK3_Spur        ------------------------------------------------------------
n1163_Tthe       -------------NFG--------------------------------------------
CC1G_03802_Ccin  ------------------------------------------------------------
AqueK117_Aque    ---AS---NDVH------------------------------------------------
GSK_b_Smoe       ------------------------------------------------------------
GSK_a-2_Smoe     ------------------------------------------------------------
GSK_a-1_Smoe     ------------------------------------------------------------
GK035_Glam       ------------------------------------------------------------
GK036_Glam       ------------------------------------------------------------


GSK3B_Hsap       ------------------------------T-----------------------------
GSK3A_Hsap       ------------------------------T-----------------------------
Pk34A_Dmel       ------------------------------------------------------------
sgg_Dmel         PSAVAAGGANAAVAGGAGGGGGAGAATAAAT-----------------------------
gskt_Dmel        GEDAEDNLEEDVGDENDYDYDDGGQCNSTYI-----------------------------
GSK3B_Mmus       ------------------------------A-----------------------------
GSK3A_Mmus       ------------------------------T-----------------------------
R03D7.5_Cele     ------------------------------------------------------------
F21F3.2_Cele     ------------------------------SA----PGKRSES------NK---------
C44H4.6_Cele     ------------------------------------------------------------
C36B1.10_Cele    ------------------------------------------------------------
RIM11_Scer       ------------------------------------------------------------
MRK1_Scer        ------------------------------------------------------------
MCK1_Scer        ------------------------------------------------------------
Y106G6D.4_Cele   ------------------------------SLNNVKKGGCSSTRCILARNKCMTQSIGGT
Y106G6E.1_Cele   ------------------------------------------------------------
Y18D10A.5_Cele   ------------------------------------------------------------
YOL128C_Scer     ------------------------------------------------------------
GlkA_Ddis        ------------------------------S-----------------------------
GSK-3_Ddis       ------------------------------S-----------------------------
19912_Tthe       ------------------------------------------------------------
19923_Tthe       ------------------------------------------------------------
19924_Tthe       ------------------------------------------------------------
2636_Tthe        ------------------------------------------------------------
5825_Tthe        -----------------------G---SMMS-----------------------------
7876_Tthe        ------------------------------------------------------------
GSK3_Spur        ------------------------------------------------------------
n1163_Tthe       -----------------------G---SMMS-----------------------------
CC1G_03802_Ccin  ------------------------------------------------------------
AqueK117_Aque    ---------------------------TTVV-----------------------------
GSK_b_Smoe       ------------------------------------------------------------
GSK_a-2_Smoe     ------------------------------------------------------------
GSK_a-1_Smoe     ------------------------------------------------------------
GK035_Glam       ------------------------------------------------------------
GK036_Glam       ------------------------------------------------------------


GSK3B_Hsap       --------------GD-------R--GQTNNAASASASNST
GSK3A_Hsap       --------------SS-------D--WQS-TDATPTLTNSS
Pk34A_Dmel       ----------------------------EDKYSVVEAFEAV
sgg_Dmel         --------------AT-------G--AIGATNAGGANVTDS
gskt_Dmel        ---SDD--------MD-------E--ASESDDDDFEEEDEN
GSK3B_Mmus       --------------GD-------R--GQTNNAASASASNST
GSK3A_Mmus       --------------GQ-------D--WQPSDATTATLASSS
R03D7.5_Cele     ---------------------TTE--KAEKESDSTNEELED
F21F3.2_Cele     --------TAAIAKKS-TMKSVMN--------APPPRQKPE
C44H4.6_Cele     ---------------------------------EGDKVECL
C36B1.10_Cele    ----------------------------DVTLTNESVEHST
RIM11_Scer       ------------------------------SVKKKLYPKSK
MRK1_Scer        ------------------------------HF-VSAPSSSL
MCK1_Scer        ------------------------------------TKVAE
Y106G6D.4_Cele   QIQFCCCNTGDLCNSKLTNMSFFE--KTKQRAKDFLDMLRG
Y106G6E.1_Cele   ----------------------------DTTLTNESVEQTS
Y18D10A.5_Cele   ---------------------------EVSTTSGDVAGPSA
YOL128C_Scer     --------------------------------------SLD
GlkA_Ddis        ---IDNSNNGKSSSSS-------NNIPSLNNSNNGVITNTI
GSK-3_Ddis       --------------ST-------T--NNTTTTTTTTTTSNH
19912_Tthe       -----------------------------AGEDKNHFNQEY
19923_Tthe       --------------------------------DNRSSDDSN
19924_Tthe       ----------------------------------TEAQNQY
2636_Tthe        --------------------------------------KYP
5825_Tthe        --------------SS-------Q--SNPNMGNYQKNYQYH
7876_Tthe        -----------------------------------SKKSYS
GSK3_Spur        -----------------------D---APETSTSATASSAT
n1163_Tthe       --------------SS-------Q--SNPNMGNYQKNYQYH
CC1G_03802_Ccin  --------------LD----------TFVPIPLEQMKISLD
AqueK117_Aque    --------------MT-------T--PDPTSELMGPNATGQ
GSK_b_Smoe       -----------------------------------VPFLAL
GSK_a-2_Smoe     -----------------------------------VPFLAL
GSK_a-1_Smoe     -----------------------------------VPFLAL
GK035_Glam       ---------------------------------------PQ
GK036_Glam       --------------------------------EQFNILSSH