Protein (view, download) , Domain (view, download)
LRRK2_Hsap      -------------GDGSFGSV-YRAAYEG---------EEVAVKIFNKH-----------
LRRK1_Hsap      E----DE--GSVLGQGGSGTVIYRARYQG---------QPVAVKRFHIKKF-KNF-----
CG5483_Dmel     I----IK--GSLLGRGAFGFV-FKANCKSA---------LMAFKVAVG------------
LRRK2_Mmus      -------------GDGSFGSV-YRAAYEG---------EEVAVKIFNKH-----------
LRRK1_Mmus      E----GE--NSILGQGGSGTVIYQARYQG---------QPVAVKRFHIKKF-KNS-----
T27C10.5_Cele   L----KR--SRMLGRGAFGFV-FRATVRQPNG----ELCEVAQKMLEPVDP-GPG-----
GbpC_Ddis       V----KI--NKEVGRGAFGIV-YEAEWMS---------EWIALKKLLLPSS-TDT-----
Pats1_Ddis      L----MI--EELIGEGGAALV-YRARWQG---------QTVAVKKLKTIEN-LDS-----
QkgA_Ddis       I----LY--ERQIGEGGFGLI-HKGKLISN-------KSDIAIKSLILCNS-NNN-----
QkgA_C2d_Ddis   I----LY--ERQIGEGGFGLI-HKGKLISN-------KSDIAIKSLILCNS-NNN-----
Roco10_Ddis     V----FN--APLLGA----------------------------------D----------
Roco11_Ddis     V----VC--EEQIGVGGFGLV-HKGKLILQD-----KSLVVAIKSYIVGNS-S-------
Roco4_Ddis      I----EY--EKQIGKGGFGLV-HKGRLVKD-------KSVVAIKSLILGDS-E-------
Roco5_Ddis      L----EI--IEKVGEGGFGIV-YKGKLRG---------QLVAIKQITIDSG---------
Roco6_Ddis      I----EFESPKLIGRGASGKI-YRANLND---------TMVAVKQLEVVG----------
Roco7_Ddis      L----KF--GPQLGSGSYANV-YRGIWNG---------SEVAIKVLNFDD----------
Roco8_Ddis      L----IY--QEEIGVGGFSRV-YKGIYKN---------NTVAIKQFNFERM-DL--IDS-
Roco9_Ddis      FKEVELD--PNPIGEGGTATV-YKGKWRQ---------SDVAIKLLKTDVV---------
LRRKd_Spur      M----VS--GQSLGQGGFGEV-FRAKFRG---------ETVAAKTMLPSRLLKNRMFSSA
LRRKc_Spur      M----VS--GQSLGQGGFGEV-FRAKFRG---------ETVAAKTMFPSRLLKNQMYSSP
LRRKb_Spur      Q----RA--ENLLGDGSFGSV-YKGTYRD---------KPVAVKVFSKGGE---------
LRRKa_Spur      L----EI--QRLLGSGTFGLV-FQGVMARASE----HRRPIAAKMLQPYPP-GQG-----
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   E----DK--DSLLGEGGFGKV-YRGKCRG---------KSVAIKKYLTR-----------
AqueK487_Aque   I----SK--LEVLGSGGFGSV-YKGLIEEGQ-------VTVAIKEFSSIAG-KME-----
AqueK488_Aque   ------------VGCGCFGVV-YHKRLQLEQYDP-DISREVAVKEFRSSDM---------
AqueK489_Aque   S-----------------------------------------------------------
AqueK490_Aque   T----VK--KHLF-----------------------------------SE----------
AqueK491_Aque   V----DR--GKFVASGSFGEI-YHGAIYPHLSASDDEGREVAIKIDKQD-R---------
AqueK492_Aque   E----DK--DSLLGEGGFGKV-YRGKFHG---------KSVAIKKYLTR-----------
AqueK493_Aque   E----DK--DSLLGEGGFGKV-YRGKFRS---------KSVAIKKYLMR-----------
AqueK494_Aque   -----------VLGKGGFGEV-FKALYNE---------KSVAIKVFSPRVA-E-------
AqueK495_Aque   -------------------QV-YKGTYYNQ---------PVAIKVFPIDSS---------
AqueK496_Aque   I----LE--KEVLGKGGYGFV-CTGELKGPTGS---PPELVAVKVFLTNLE-GKI-----
AqueK497_Aque   K----DL--STRLGRGGAGAV-YKGKYRNV---------PVAVKEFLTQSQ-ADA-----
AqueK498_Aque   V----LK--KERLGRGAFATV-YHAQIKRKLPNGQIHFEDVAIKALGNKGE-D-------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      -------------------------------------------------AN---------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      -------------------------------------------------AN---------
T27C10.5_Cele   -----------------------------------------------G-RPSALA-----
GbpC_Ddis       -----------------------------------------------TNLNGNGE-----
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       -----------------------------------------------NNSNNNNN-----
QkgA_C2d_Ddis   -----------------------------------------------NNSNNNNN-----
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ---------TSFNNLNSLTISPSNSSLSISLSSSTSSLSPPIVNNNNNNNNLNNNLNNLN
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      SEGYASCAST-----------------------------------SSSTSNRTGE-----
LRRKc_Spur      SEGYASCAST-----------------------------------PSSTSNMTGE-----
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      -----------------------------------------------A-GNTDRR-----
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   -----------------------------------------------D-SLS--------
AqueK497_Aque   -----------------------------------------------F-QDEDEL-----
AqueK498_Aque   -----------------------------------------------L-DDDDDE-----


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      NNNKLYIQQQQQTQQNQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQNQQQPKILQ
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      -------------------------------------------------TSLRLLRQELV
LRRK1_Hsap      ------------VPA-----------------D--TMLRHL--RATDAMKNFSEFRQEAS
CG5483_Dmel     ------------------------------------KWDRD--PLQHSCKAYCTARQELA
LRRK2_Mmus      -------------------------------------------------TSLRLLRQELV
LRRK1_Mmus      ------------APA-----------------D--TMLRHL--RAMDAMKNFSDFRQEAS
T27C10.5_Cele   ----------AYKAA-----------------A--DKWKRD--SMEFACRAYCTSRQELS
GbpC_Ddis       ----------VM-VY-----------------D----DPDQ--LIEDRLRVFREFRHEVY
Pats1_Ddis      -------------------------------------PIEI--NDISLSKAFNEFRRECW
QkgA_Ddis       ----------SN-NS-----------------N--NFKNNN--NEDEFIEKFQEFQHEVF
QkgA_C2d_Ddis   ----------SN-NS-----------------N--NFKNNN--NEDEFIEKFQEFQHEVF
Roco10_Ddis     -------------------------------------------FQNNCARILSSFRHEAL
Roco11_Ddis     --------------------------------------------ASDIIRKFQEFHHEMY
Roco4_Ddis      -------------------------------------------GETEMIEKFQEFQREVF
Roco5_Ddis      -------------------------------------------QAEAASEIYREFRREVW
Roco6_Ddis      ---------------------------------------------EDAPRIFSEFRREIH
Roco7_Ddis      -------------------------------------------GHANTTEKYREFRNEAH
Roco8_Ddis      RNLSTSSLSSNSSQG-----------------E--DSMNQI---SSGKLNAINEFRREVW
Roco9_Ddis      --------------------------------------------GSDFSKVFAEYRREIF
LRRKd_Spur      ----------STSTE----------------------NDSL--EAAMLMESFHKLRNEVA
LRRKc_Spur      ----------STSTE-----------------N--DSCDSL--EAAMLMDSFHKLRNEVA
LRRKb_Spur      ------------------------------------------------SHPHRLLRQEVT
LRRKa_Spur      ----------RYDND-----------------N--TKWHRD--PLRFSCEAYRTARKELS
AqueK485_Aque   -----------------------------------------------------KLYQDFD
AqueK486_Aque   -----------------------------------------------TEEAFNELRSEAK
AqueK487_Aque   -------------------------------------EDTLIGHELNAWDIYINGSREAR
AqueK488_Aque   --------------------------------------DYD--AELEVVKSYADMRYELN
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   --------------------------------------------SKSYSVPLSAMRQELE
AqueK491_Aque   --------------------------------------KHF--NMETAAKAYTEIRAEVA
AqueK492_Aque   -----------------------------------------------QEEAFNELRHEAK
AqueK493_Aque   -----------------------------------------------QEEAFNELCHEAK
AqueK494_Aque   ---------------------------------------------LHSTTPNQLIRQEVS
AqueK495_Aque   ---------------------------------------------ANHFTVLRLHRSELS
AqueK496_Aque   -------------SA-----------------E--LLEEAA--KDSQLRSAYKEIRQEVN
AqueK497_Aque   ----------PPGGI-----------------HTYHDDDSI--SSGEALFLYRDMRQEVT
AqueK498_Aque   ------------DISLDEEEERPGGDDEYDGENARE-PPPI--QRSAIISGFNNLKKELS


LRRK2_Hsap      VLCHLHHPSLISLLAAGIRPR-MLVMELASKGSLDRL-----LQQDK-------------
LRRK1_Hsap      MLHALQHPCIVALIGISIHPL-CFALELAPLSSLNTV-----LSENARDSS---------
CG5483_Dmel     VLLTLKHPNIVPLVGICIKPL-ALVLELAPLGGLDAL-----LRHYRRSG----------
LRRK2_Mmus      VLCHLHHPSLISLLAAGIRPR-MLVMELASKGSLDRL-----LQQDK-------------
LRRK1_Mmus      MLHALQHPCIVSLIGISIHPL-CFALELAPLGSLNTV-----LSENAKDSS---------
T27C10.5_Cele   LLSRMKHPNVIGLVGVCTFPL-SLVVELAPLGALNQL-----LGSHRKAG----------
GbpC_Ddis       YMSGLNHPNVMKISGFCIQPL-CMALEYVRYGSLYSL-----LSNSS-------------
Pats1_Ddis      VMSELEHPNIVQLKGLCLDPL-CIVTEYLPHGNLYSF-----LHKPE-------------
QkgA_Ddis       IMSNLNHPNIVKLYGLMHNPP-RMVMEYVEHGDLYHL-----CQDKE-RY----------
QkgA_C2d_Ddis   IMSNLNHPNIVKLYGLMHNPP-RMVMEYVEHGDLYHL-----CQDKE-RY----------
Roco10_Ddis     SLYNFRHSNVLSIIGISMNPI-AIITENPTFGSKGSTTLSEYIQDR-QKH----------
Roco11_Ddis     IMSSLNHLNIVKLFGSMQNPP-RMVMEFAPHGDLYHF-----LEKKK-------------
Roco4_Ddis      IMSNLNHPNIVKLYGLMHNPP-RMVMEFVPCGDLYHR-----LLDKA-------------
Roco5_Ddis      LSNTLTHPSIVSLKGYCLDPC-CIVMEYIPNGTLYSH-----LRKSF-------------
Roco6_Ddis      VMSDLKHSNVVNLLGFTLSPF-TMVMEYIDCGDLHKF-----LHSPIGDQ----------
Roco7_Ddis      ITGELRHANTVSLMGVSLSPF-CLVTELLQYGDLAKF-----IRNT---A----------
Roco8_Ddis      LMSGLSHSNIVLMKGFCFEPY-AIVMEYMDIGSLSSF-----LKKKKEDG----------
Roco9_Ddis      CLSSFIHDNILDLKGFCLEPL-AIITEFQSGGNLYDY-----IHDLK-------------
LRRKd_Spur      IMAKLDHPYIVNLVGVSIRHL-CFAMDYAPLGDLRSY-----LFAEHQSARP---HFVKR
LRRKc_Spur      IMVKLDHPCIVNLVGVSIRHL-CFAMDYAPLGDLQSY-----LFAEHQSARP---HFVKR
LRRKb_Spur      VLRHLQHPSLVSMEGVGLNPR-ILVMELAPLGSLNTL-----LASGR-------------
LRRKa_Spur      IINNLDHPHIVPLLGFCRHPM-CLILELAPQGALDTR-----MENFKRVG----------
AqueK485_Aque   LLKNLSTPHIISSLGFHYSVP-VLALELSPLGSVRKY-----LNDGNK------------
AqueK486_Aque   VLQESHHPFLVCLVGVSVHPLMALILEEAPMGSFERH-----LIKKS-------------
AqueK487_Aque   MMHQLQHKNILSLVGLAFQPL-RLILELAPLGDLKNS-----LKPFRQEK----------
AqueK488_Aque   KLCMMEHDFVVEFVGLLTNPW-SFILEWAPLMSLEKI-----RKSYEEQFKT--------
AqueK489_Aque   ---------------------------------MEDV-----ILEHTI------------
AqueK490_Aque   MLSLLSHPNIIKAYGYCFSPP-SLVIERSPLGTLLQK-----LSDNEQ------------
AqueK491_Aque   LLKDLDHEYIINFIGLTLQPL-CFMLEWASKGSLHGI-----LQSYYRTD----------
AqueK492_Aque   LLQKSYHPSIVCLVGVNVHPLTALILEEAPMGSLDRH-----LIKES-------------
AqueK493_Aque   LLQKSHHPFIVCLVGVNVHPLTALILEEAPMGSLERH-----LIKES-------------
AqueK494_Aque   ILSQMDHPNIIGLVGVCLRPKPMLLIEYAELGSLSSF-----SP-Y--------------
AqueK495_Aque   VLTNISHQYLISTAGFLTAPL-SIVFPLAPLGSLQDH-----LDLCP-------------
AqueK496_Aque   FLSTLKHQNITKLIGVRTKPVYCLLLELAPMKSLRSM-----LKDYQLCK----------
AqueK497_Aque   VLAQLSHPNIVSILGVSLRPM-CIALELAPMGSLFGI-----LDKKLEAIKTAQADLPTA
AqueK498_Aque   ILSPLRHPYIIQLFGVSARPL-GLVLELAPKGSLKSL-----LKEYSEAQ----------


LRRK2_Hsap      ----------ASLTRTLQHRIALHVADGLRYLHSA--MIIYRDLKPHNVLLFTLYP----
LRRK1_Hsap      -----F----IPLGHMLTQKIAYQIASGLAYLHKK--NIIFCDLKSDNILVWSLD-----
CG5483_Dmel     ----------AHMGPHTFQTLVLQAARAIEYLHRR--RIIYRDLKSENVLVWELPQPHT-
LRRK2_Mmus      ----------ASLTRTLQHRIALHVADGLRYLHSA--MIIYRDLKPHNVLLFTLYP----
LRRK1_Mmus      -----F----MPLGHMLTQKIAYQIASGLAYLHKK--NIIFCDLKSDNILVWSLS-----
T27C10.5_Cele   ----------TKLSLGVIKESAVQVARALEYLHSA--HIIYRDLKSENVLGWRFPAPF--
GbpC_Ddis       ----------IEISWGLRLQIASEIAKGMQHLHSHNPPVIHRDLKSPNILLNGIT-----
Pats1_Ddis      ----------MEFSWLFRLKVALDISSGMAFLHSSTPPIIHRDLKSPNILLASIN-----
QkgA_Ddis       ----------ASLGWTLKLRLMIDIAKGIGYMQNQNPPIVHRDLRSPNIFLKSLD-----
QkgA_C2d_Ddis   ----------ASLGWTLKLRLMIDIAKGIGYMQNQNPPIVHRDLRSPNIFLKSLD-----
Roco10_Ddis     ----------PEIPWNIKLKIALDIARAMDKLNSHSPPFLLTNLTSSGIILEKSNDHQSS
Roco11_Ddis     -----------NIKWSFKVRLMLDIAKGIEYLQNQNPPIVHRDLRSPNIFLFSLD-----
Roco4_Ddis      ----------HPIKWSVKLRLMLDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLD-----
Roco5_Ddis      ----------SSITWQLKLKIAINIADAIKHMHGFTPKICHRDLKSPNILMLS-D-----
Roco6_Ddis      ----------LNGNWALILKLALDIAKGMEFLHSVTPPLLHRDLKSPNVLLSMKD-----
Roco7_Ddis      ----------ETFSWGTVLKLAIDVAKGMNFLHSCKPMIVHRDLKSANILLGGSS-----
Roco8_Ddis      ----------QVLDWQMLLKIVTDIASGMAFLHNITPPLVHRDLKSPNILLASHP-----
Roco9_Ddis      ----------NPLDWQLRIKIAKGIAASLQTLHDSRPSVVHRDLKSPNILLSSKD-----
LRRKd_Spur      NI-VLE----PVLSRMLTYKISLQVASAVGYLHRK--DIIYCDLKTDNILLFSSD-----
LRRKc_Spur      NI-VLE----PVLSRMLTYKISLQVASAVGFLHSK--DIIYCDLKTDNILLFSSD-----
LRRKb_Spur      -----------IKNRNLQHRIAMQVAEGLAFLHKN--RIVYRDLKPDNVLIFSLAL----
LRRKa_Spur      ----------ARLTPHTLQELVVQVSSAVAYLHSK--DIIYRDLKAENVLVWKFPQPYS-
AqueK485_Aque   ------------LLQSGVHQIALQVLSAIKY-----------------------------
AqueK486_Aque   ----------TPIPRLTMFRIAAQVAAALRFLHQH--GIIFRDLKAANVLLWSLD-----
AqueK487_Aque   ----------IKLNCRTLKQLIYQVADAME------------------------------
AqueK488_Aque   -----HKPEYYYLCPVSLYLILLQVCDGLHYLHAPPIGIIHSDLKLSNI-----------
AqueK489_Aque   -----------SVSPFLRMRIVYQLASALKTLHSL--KIIHRNVCLENIIVYSLS-----
AqueK490_Aque   -----------KISRLVRFHISCQVASALAYLHKH--NVIYRTLKSDSVLTWSLE-----
AqueK491_Aque   ----------SKVSPWTLVEAGRQVANGLSYLHSR--NVVYYDLKSPNILVFEFPSADES
AqueK492_Aque   ----------TPIPRLTMFRIAAQVAAALRFLHQH--GIIFRSLKAANVLLWSLD-----
AqueK493_Aque   ----------TLIPRLTMFRIAAQAAAALRFLHQH--GIIFRSLKAANVLLWSLD-----
AqueK494_Aque   ----------STVSPSLKHRIAMQVASALAFLHKN--NIIYRDLKPSNILIFSLSL----
AqueK495_Aque   ----------SGIGDKISHVLLHQVAQGLQYLHSL--HIIHRDIKPGNILVWSLT-----
AqueK496_Aque   ----------LTMEPITLKQCAKQISDGLNYLHTH--QIVHLDMKSPNVLVWEFPIAGMP
AqueK497_Aque   NIKMPG----GVLGHQISARIALQVALATRYLHKI--GIVYRDLKSDNVLIWSLDV----
AqueK498_Aque   ----------THIQSSAMQAVTLQISDALKYLHDL--RIIYRDLKSDNVLVWQFPSPYDV
                                           .

LRRK2_Hsap      ---------------N-AAIIAKIADYGIAQYCCRM-GI---KT-----SEGTPGFRAPE
LRRK1_Hsap      --------------VK-EHINIKLSDYGISRQSFHE-GA---LG-----VEGTPGYQAPE
CG5483_Dmel     ----E------D-SPR-NLVHIKIADYGISRQTAPS-GA---KG-----FGGTEGFMAPE
LRRK2_Mmus      ---------------N-AAIIAKIADYGIAQYCCRM-GI---KT-----SEGTPGFRAPE
LRRK1_Mmus      --------------AK-EHINIKLSDYGISRQSFHE-GA---LG-----VEGTPGYQAPE
T27C10.5_Cele   -------------SPQ-TDVLLKLGDYGISRSVLPSGGA---KG-----FGGTEGFMAPE
GbpC_Ddis       --------------EG-QNSVATIIDFGTSTALYGG-AA---LI----RCVDQPLWLGPE
Pats1_Ddis      --------------EN-AQTIAKVVDFGLSGLQHTI--T---N-----RGVENPLWLAPE
QkgA_Ddis       --------------EN-SPVCAKIADFGLSQQSV-Y-SV---SG-----LLGNFQWMAPE
QkgA_C2d_Ddis   --------------EN-SPVCAKIADFGLSQQSV-Y-SV---SG-----LLGNFQWMAPE
Roco10_Ddis     -GNGL--------EIE-PFVNAKIIDFSQSSFLPSL--F---PT-----STTPKSYHSPE
Roco11_Ddis     --------------EN-APVCAKVADFGLSQQSL-Y-SV---SG-----LLGNFQWMAPE
Roco4_Ddis      --------------EN-APVCAKVADFGLSQQSV-H-SV---SG-----LLGNFQWMAPE
Roco5_Ddis      --------------MN-AAVVCKVSDFGETRAVVTS-AL---GR----DKLSNPIWLSPE
Roco6_Ddis      -----------------GVYTAKVGDFGLSSRMFIQ-AL---KHKLRNFPVGNITWVAPE
Roco7_Ddis      --------------M--DNLVAKVGDFGLSIKPIGK-EV---KG----RKVWNWRWLAPE
Roco8_Ddis      --------------TNPNEISAKVSDFGLSRSIVQN-FS---SK-----VVDNPTWQSPE
Roco9_Ddis      --------------S--LTMECHLCDFSLSGFSTTV--A---N-----RSVQNPVWLAPE
LRRKd_Spur      --------------VN-EDVNIKLIDYGISKKYDLM-GA---MG-----MAGTPGFCAPE
LRRKc_Spur      --------------VN-EDVNIKLTDYGISRKYDLM-GA---MG-----MAGPPGFCAPE
LRRKb_Spur      ---------------G-TLQNAKISDYGISRFATPY-GL---KS-----SEGTPGYRAPE
LRRKa_Spur      ----P--------NPA-DPIKVKLADYGISVTALPS-GT---KG-----YGGTPGYMAPE
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   --------------ET-SLCH---------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   --------------LD-EQVNIKLGGFSRSCLEMSQ-GL----A-----VGEHGRFPAPE
AqueK490_Aque   --------------FE-DEVSVKLAHFDRAAFSTPT-GI---LS-----KTDFSFYPAPE
AqueK491_Aque   LRVSLESSPVLDKLG-KFPVHVKITDLGISRKITPG-GV---VG-----YKGTPAFMAPE
AqueK492_Aque   --------------ET-SLCHSKLTDFGIATHLAPL-GV---MG-----IQGDKCVIAPE
AqueK493_Aque   --------------ET-SLCHSKLTDFGIATHLAPL-GV---MG-----IQGDKSVIAPE
AqueK494_Aque   ---------------N-SPVNAKLSDYGISTFATTT-GL---NQ-----DIGTAGYKAPE
AqueK495_Aque   --------------LS-DGILVKITDYGSSYYIDTF-GC---KG-----SRGTEDYMAPE
AqueK496_Aque   RKERL--------KYA-GNVWLKIADYGISQVATSM-MMKVTTN-----QPGTPGYMAPE
AqueK497_Aque   ---------------N-ESVNAKLADYGISRFANPG-GI---KG-----EEGTPGYMAPE
AqueK498_Aque   LVPAL------P-VHT-DVVKVKLSDYGISQFASTQ-GA---KG-----LVGTPGFMAPE


LRRK2_Hsap      VAR--G-NVIYNQQADVYSFGLLLYDILTTGGRIVEGLK------------------FPN
LRRK1_Hsap      IRP----RIVYDEKVDMFSYGMVLYELLSGQ-RPALGHH---Q----------------L
CG5483_Dmel     IIRYNG-EEEYTEKVDCFSFGMFIYENISLR-QPFEGHE---------------------
LRRK2_Mmus      VAR--G-NVIYNQQADVYSFGLLLHDIWTTGSRIMEGLR------------------FPN
LRRK1_Mmus      IRP----RIVYDEKVDMFSYGMVLYELLSGQ-RPALGHH---Q----------------L
T27C10.5_Cele   IVRFNG-EEEYTQKVDCFSFGMFLYELLTLK-FPFESEE---------------------
GbpC_Ddis       VLAG----TAYSEPSDVYSFGIILWELYTRA-HPFDEFQ-FGQ--------------WMS
Pats1_Ddis      ILNK---TKEASTQTDVYAFGVILWELVTRK-DYFGEIG-F-----------------MT
QkgA_Ddis       TIGV--EDESYTEKVDTYSFAMILFTILTGE-IPFDEYS-FGKM---------------Q
QkgA_C2d_Ddis   TIGV--EDESYTEKVDTYSFAMILFTILTGE-IPFDEYS-FGKM---------------Q
Roco10_Ddis     VLQ----KLNYHENSDVYSFGIILYELLTRS-IAFQDHD-----R---------------
Roco11_Ddis     TIG---AEESYTEKIDTYSFSMILFTILTGE-CPFDEFTSFGKM---------------E
Roco4_Ddis      TIGA--EEESYTEKADTYSFAMILYTILTGE-GPFDEYS-YGKI---------------K
Roco5_Ddis      IMRG----DEYTEKADVYSFGIVLWEILTGL-LPFDEYP-VAHSS------------FMY
Roco6_Ddis      ILR----EEEYTVKSDVYAFGLILHELLTRK-HPYREFN-YSMV---------------S
Roco7_Ddis      CMG----DGQYTEKIDIYSYAIVLWEIITRD-LPFEEYVD--QLK------------WNS
Roco8_Ddis      VLK----GMEYNEKSDIYSFGMILWECYHLE-LPFDEFD-F-K--------------FMS
Roco9_Ddis      VINN----ELCSDKSDVYAYGVILFELLSRT-RFFSNIT-F-----------------MS
LRRKd_Spur      ILQ----GKTFDEKVDWFSYGMFLYHLMTGL-VPYYDQH-S-R----------------I
LRRKc_Spur      ILQ----GKVFDEKVDWFSYGMFLYHLMTGL-VPYYDQH-S-R----------------I
LRRKb_Spur      VIR--G-TSNYNTEVDIYSFGILLYELVSEGHRPFEEME------------------FRT
LRRKa_Spur      IVQYDG-KETYNEKVDCFSFGMFMFELMSLQ-RPFECLVGKDVGR------------LSE
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   MSNY---LYEYDQRADVFSFAFTSYEILTRK-KL-KCRK---G----------------V
AqueK490_Aque   MVRY-EFSEEYTEKVDIYSFGILLYELVARW-QPFTSDK-T-A-----------------
AqueK491_Aque   ILRYV-GKEACTEKVDVFSFGMFMYELLAQQ-FPFERQ----------------------
AqueK492_Aque   VLYIGQKRTIYNHKADIFSFGMLLYQMIARR-HPFHNVQ-P------------------V
AqueK493_Aque   VLYIGQKRTIYNHKADIFSFGMLLYQMIARR-HPFHNVQ-P------------------V
AqueK494_Aque   ILKAKTSKMPYNTMVDIYSFGIVLFQLVTDGHTPFEELMP-------------------H
AqueK495_Aque   LYLSA-RKRNYDEKVDIFSFGILLFNVVTGK-KFAPNFN-RSRHEAGGRREAFLSIPHLS
AqueK496_Aque   LFET--GQEIYSTKVDVFAYGMTLYEIISLQ-APFQKQE-AMKR----------------
AqueK497_Aque   AIKRRGEDQAFDEKVDIFSFGMLLFELITGQ-RPFESMS------------------TGQ
AqueK498_Aque   ILMYYG-KEAYNEKVDIFSFAMLIYEMITFR-LPFEHLT-------------------PS


LRRK2_Hsap      ------------------EFDELEIQGKLPDPVKEYG-----CAPWPMVEKLIKQCLKEN
LRRK1_Hsap      ------------------QIAKKLSKGIRPV-LGQP-----EEVQFRRLQALMMECWDTK
CG5483_Dmel     ------------------SIKECILEGSRPA-LTQRE-----TQFPTCCLDLMVLCWHEQ
LRRK2_Mmus      ------------------EFDELAIQGKLPDPVKEYG-----CAPWPMVEKLITKCLKEN
LRRK1_Mmus      ------------------QIVKKLSKGIRPV-LGQP-----EEVQFHRLQALMMECWDTK
T27C10.5_Cele   ------------------HVKERMLDGARPV-LLPHE-----LLLPTPMLDLLVHCWSAH
GbpC_Ddis       ------------------KLEDEIIRGLRPT-IPPTC--------PPEYVELIQSCWTHE
Pats1_Ddis      ------------------LIEEKVINGERPK-IPEDC--------PEMYSKLIVECWQTD
QkgA_Ddis       ------------------FINLIREENLRPT-LPFD-------C-DPRLSNLIQLCWSTN
QkgA_C2d_Ddis   ------------------FINLIREENLRPT-LPFD-------C-DPRLSNLIQLCWSTN
Roco10_Ddis     -------------------FSNIVISGQRPS-IPLD-------C-LPSFADLIKDCWSGE
Roco11_Ddis     ------------------FIRKIREEDLRPT-IPSD-------C-PPTISNLIELCWSGD
Roco4_Ddis      ------------------FINMIREEGLRPT-IPED-------C-PPRLRNVIELCWSGD
Roco5_Ddis      ------------------QLEDEITNGLRPT-IPQNSV-----CGHPDFITLITDCWQND
Roco6_Ddis      ------------------LQEDAIKNGLRPT-ISPSYT---QTVTGHEYCGLIQDCWDSD
Roco7_Ddis      ------------------IIEDKIMKGLRPT-IPNE-------C-PPDMKQLITDCWSGD
Roco8_Ddis      ------------------TLEDNILSGLRPS-INQ--------NCNRMYSSLITKCWNAD
Roco9_Ddis      ------------------EVEGLITEGVRPS-LPSHN--------LPEYDSLLNICWAQD
LRRKd_Spur      ------------------EIELAVNEGRKPT-FNFHEYTMPPKQVFPALGALMESCWQNK
LRRKc_Spur      ------------------EIQLAVNEGRKPT-FNFHEYKMPPRQVFPALGALMESCWQDK
LRRKb_Spur      ------------------EIDEAVIKGQHLPPISQGG-----VAPWPDLQELIDHCTEHV
LRRKa_Spur      ------------------VIKQLIKDGQRPV-LSRKE-----KSYPTYMLDLLSWCWAQD
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------RFQTATGNADRPN-LKPL-----N-GLCPYFTPLLDKCWNND
AqueK490_Aque   -------------------------MAHKPK-LTGL-----STYGFGSLVKLMEECWEED
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------RIDTKVVQGDRPS-TVDMPI---AETGYFFLTRLMEKCWKDK
AqueK493_Aque   ------------------RIDTKVVQGDRPS-TVDMPI---AETGYFFLTRLMEKCWKDK
AqueK494_Aque   ------------------EKDKAVEEGRLIKD-PSYY----GGAPWPDMHDIIRHCLQYV
AqueK495_Aque   IIASAIEEQRLVGSSNQSPATLLLKDGVHPA-AREGHI---STCISTCMQVILEDCLSID
AqueK496_Aque   --------------------NAEVRAGKRPP-TGN--K---EKHTPLLLQDLMRLCWSKD
AqueK497_Aque   ------------------EVNRAVIQRERPQ-VSEGN----MEPSFPGMIELMEDCWRHL
AqueK498_Aque   ------------------QANQANENGARPT-LKRID-----LPCPVLIRELMVWCWQQS


LRRK2_Hsap      PQERPTSAQVF------------------------------------DI
LRRK1_Hsap      PEKRPLALSVVSQMK------------------------------DPTF
CG5483_Dmel     PRRRPTASQIV------------------------------------SI
LRRK2_Mmus      PQERPTSAQVF------------------------------------DI
LRRK1_Mmus      PEKRPLALSVVSQMK------------------------------DPTF
T27C10.5_Cele   PESRPSSSQLV------------------------------------GF
GbpC_Ddis       PNSRPTFTSIVEIL--------------------------------GQI
Pats1_Ddis      ASQRPKFSEIED-----------------------------------RL
QkgA_Ddis       PKKRPSFTFIIKEL---------------------------------LE
QkgA_C2d_Ddis   PKKRPSFTFIIKEL---------------------------------LE
Roco10_Ddis     PLNRPSPSKII-------------------------------------S
Roco11_Ddis     PKKRPHFSY---------------------------------------I
Roco4_Ddis      PKKRPHFSYIV-------------------------------------K
Roco5_Ddis      PLKRPTFID---------------------------------------I
Roco6_Ddis      IDRRPTFNKIVKRIK-------------------------------QII
Roco7_Ddis      PKKRPSFNSILERL--------------------------------STM
Roco8_Ddis      PNLRPSFNSILK-----------------------------------TL
Roco9_Ddis      PTCRPSFIEITKKLEEIELIL--KTHTPVEPVYTE-----TSKNQHIQL
LRRKd_Spur      PGERPHGETTLQLLS------------------------------EPSF
LRRKc_Spur      PGKRPHGKTILQLLS------------------------------EPSF
LRRKb_Spur      PESRPTAQEAFEK---------------------------------LSS
LRRKa_Spur      SRDRPSMEQIK------------------------------------DV
AqueK485_Aque   ------------------------------------------------L
AqueK486_Aque   -----------------------------------------------SK
AqueK487_Aque   ------------------------------------------------Y
AqueK488_Aque   ------------------------------------------------L
AqueK489_Aque   PHKRPYFIEILH-----------------------------------QF
AqueK490_Aque   PTLRPSALDLLH-----------------------------------LL
AqueK491_Aque   ------------------------------------------------N
AqueK492_Aque   ADDRPETSELISD---------------------------------VSK
AqueK493_Aque   ADDRPETSELISD---------------------------------VSK
AqueK494_Aque   PNNRPRAQDIFDRMCMPDF----------------------MALRHVVP
AqueK495_Aque   PIKRPTAEGVASR---------------------------------LVI
AqueK496_Aque   PSARPKMKECLQ-----------------------------------WT
AqueK497_Aque   AADRPTADEVVQR---------------------------------ISA
AqueK498_Aque   EELRPTASQITKVSQMDQF-LRLADAIRVNNFGSQVAGSCYRILKSPVF