Alignment of Family LRRK

Protein (view, download) , Domain (view, download) 
LRRK2_Hsap      MASGSCQGCEE-D-----------------------------------------------
LRRK1_Hsap      MAGMSQRPPSM-----Y--WCV--G-----------------------------------
CG5483_Dmel     MEHPKTGTETA-L---E--ACD-------------------YFVDE--------------
LRRK2_Mmus      MASGACQGCEE-E---E--E----------------------------------------
LRRK1_Mmus      MAGTSQRPPSM-----Y--WCV--G-----------------------------------
T27C10.5_Cele   MDLSSGGPSSS-S---D--VAS--------------------ELDN--------------
GbpC_Ddis       MSQKQKPIRFQ-----D--YQF--T-----------------------------------
Pats1_Ddis      MEILNLSIEFHIPDGNT--L----K---------------------------KMV-RVDN
QkgA_Ddis       MDLEQDEWMSQ-----R--Q----R-----------------------------------
QkgA_C2d_Ddis   MDLEQDEWMSQ-----R--Q----R-----------------------------------
Roco10_Ddis     MSGLLDDDEII-----Q--VS---------------------------------------
Roco11_Ddis     METSQIRNGF--------------------------------------------------
Roco4_Ddis      MDSSQQLQESQ-----Q--L----Q-----------------------------------
Roco5_Ddis      MEVIKKEKKDK-----E--KK---------------------------------------
Roco6_Ddis      MNSIHKQHYTI-----N--SNH--Y-----------------------------------
Roco7_Ddis      MDGYSSLSSSG-----N--SIA--PPRPTNNSVGGGSNSNNYNQREITTPLRGMVPNLGD
Roco8_Ddis      MFDYNQLNKLK-----D--KIQ--S-----------------------------------
Roco9_Ddis      MTSIANLFDKK-----S--KRS--N-----------------------------------
LRRKd_Spur      VPQPY-------------------------------------------------------
LRRKc_Spur      MDNYDMLQDAC-----T--ALL--------------------------------------
LRRKb_Spur      MESPVTPDEER-I---R--RKL--L-----------------------------------
LRRKa_Spur      MVNMVVL-----------------------------------------------------
AqueK485_Aque   MDGTEVIVAVF-G-------CP-------------------GVGKS--------------
AqueK486_Aque   MMTAKAPDYQP-V---E--RYG--H-----------------------------------
AqueK487_Aque   MATWCSLQPV--------------------------------------------------
AqueK488_Aque   MQNMGVVKEHV-F---D--CKM--E-----------------------------------
AqueK489_Aque   MAKAAESENTS-------------------------------------------------
AqueK490_Aque   MAALLPPETQG-I---D--KAI--F-----------------------------------
AqueK491_Aque   MSGKENVYAPS-----D--VT---------------------------------------
AqueK492_Aque   MAGVMQDDAKL-L---H--KFC--H-----------------------------------
AqueK493_Aque   MGQ---------------------------------------------------------
AqueK494_Aque   MSAGAGRRRHS-M---E--ASA--F-----------------------------------
AqueK495_Aque   MLTPIIPYFLI-YG--GFSCLVVSI-----------------------------------
AqueK496_Aque   MAEVRKLAETL-----G--TIL--S-----------------------------------
AqueK497_Aque   MLSSVKFLGAG-I---D--K----------------------------------------
AqueK498_Aque   MARGSSFLRFF-----E--PSV--D-----------------------------------
                :

LRRK2_Hsap      ---EET-----------LK-KL-------------IVRLNNVQEGKQIETLVQI------
LRRK1_Hsap      ---PEE-----------SAVC--------------------------PERAMET------
CG5483_Dmel     ---VIE-----------AS-S--------------------------IRDA---------
LRRK2_Mmus      ---EEA-----------LK-KL-------------IVRLNNVQEGKQIETLLQL------
LRRK1_Mmus      ---TEG-----------LAVC--------------------------PGPAMET------
T27C10.5_Cele   ---SDA-----------MQ-L--------------------------VRQA-------VL
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ---TTK-----------I---------------------------------GEM------
QkgA_Ddis       ---QQQ-----------M----------------------------------EF------
QkgA_C2d_Ddis   ---QQQ-----------M----------------------------------EF------
Roco10_Ddis     ---PDS-----------I----------------------------------IT------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      -----------------Q----------------------------------QY------
Roco5_Ddis      ----DK-----------E----------------------------------EK------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      GSSSQT-----------L----------------------------------LF-KNILL
Roco8_Ddis      ---SDG-----------L----------------------------------QIKDRTYL
Roco9_Ddis      ---EDT-----------G-----------------------------------EKEETKK
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ----------------------------------------------------EI------
LRRKb_Spur      ---DT-LLLL--------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ---TFI-----------SN-A--------------------------LEGQ---------
AqueK486_Aque   ----ST-----------V--RVGDYLYMWGGDQPDLPRVHNNEKKKSM---CSV------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ---NE---------------D--------------------------IRTLV-T------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ---A------------------------------------------------E-------
AqueK491_Aque   ---EDL-----------T----------------------------------A-------
AqueK492_Aque   ---DGK-----------IE-KIKDFV--ATVE----------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ---SR-PALFRPHFSSTS--N--------------------------LNASV-A------
AqueK495_Aque   ---HYPI--------SSKD-V--------------------------LKSLKS-------
AqueK496_Aque   ---AEP-----------SD-N--------------------------QKKLFE-------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ---PSL-----------VD-D--------------------------TDRLIDF------


LRRK2_Hsap      ------LEDLLVFTYSERASKLFQGKNIHVPLLIVLDSYMRVASVQQVGW----------
LRRK1_Hsap      ------L--------------------------NG--------------A----------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------LEDMLVFTYSDRASKLFEDKNFHVPLLIVLDSYMRVASVQQAGW----------
LRRK1_Mmus      ------H--------------------------NG--------------A----------
T27C10.5_Cele   FEN---------------------------------------------------------
GbpC_Ddis       ----------------------------------------A------TKD----------
Pats1_Ddis      ------S---------------------------------R------LLL----------
QkgA_Ddis       ------S---------------------------------R------IGI----------
QkgA_C2d_Ddis   ------S---------------------------------R------IGI----------
Roco10_Ddis     ------S--------------------------SIGSA--S------LNY--SVNGADDN
Roco11_Ddis     ------N---------------------------------K------VEV----------
Roco4_Ddis      ------T---------------------------------R------VGI----------
Roco5_Ddis      ------K--------------------------DKEKK----------DKSEKKEKKDKE
Roco6_Ddis      -------------------------------------------------N----------
Roco7_Ddis      LQDVEFF---------------------------------C------SIL----------
Roco8_Ddis      YKTYRSV---------------------------------F------VGY----------
Roco9_Ddis      ---SRS------------------------------------------GT----------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------L--------------------------EK-------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------ME-VCHLRTGRWEQKPTT---GDPPL----------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------F--------------------------NRGK-----------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   --L---Y---------------------------------R-------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------S--------------------------SRGMQPLK------EQD----------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------L--------------------------SA-------------------------


LRRK2_Hsap      ---------------------------SLLCKLIEVCPGTMQSLMGPQ------------
LRRK1_Hsap      ---------------------------G--------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ---------------------------SLLCKLIEVCPGTLQSLIGPQ------------
LRRK1_Mmus      ---------------------------E--------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ---------------------------E--------------------------------
Pats1_Ddis      ---------------------------D--------------------------------
QkgA_Ddis       ---------------------------E--------------------------------
QkgA_C2d_Ddis   ---------------------------E--------------------------------
Roco10_Ddis     KSI---PPS------SPQQNLLE---ND--------------------------------
Roco11_Ddis     ---------------------------D--------------------------------
Roco4_Ddis      ---------------------------D--------------------------------
Roco5_Ddis      KKEKEKKEKKEKEKEKEKDKEKDGGLFS--------------------------------
Roco6_Ddis      ---------------------------E--------------------------------
Roco7_Ddis      ---------------------------D--------------------------------
Roco8_Ddis      ---------------------------ECVDW----------------------------
Roco9_Ddis      ---------------------------LKFKT----------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ----------------------------------------GVRSYAAAAIGREIFYFGGY
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ---------------------------D--------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ---------------------------E--------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      --------------DVGNDWEV--------------------------------------
LRRK1_Hsap      --------------DTGGKPSTRGGDPAARSRR---------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      --------------DIGNDWEV--------------------------------------
LRRK1_Mmus      --------------DMGSKLSLPGGSSTVQCPS---------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       --------------A---------------------------------------------
Pats1_Ddis      --------------K---------------------------------------------
QkgA_Ddis       --------------V---------------------------------------------
QkgA_C2d_Ddis   --------------V---------------------------------------------
Roco10_Ddis     --------------T---------------------------------------------
Roco11_Ddis     --------------V---------------------------------------------
Roco4_Ddis      --------------V---------------------------------------------
Roco5_Ddis      --------------I---------------------------------------------
Roco6_Ddis      --------------S---------------------------------------------
Roco7_Ddis      --------------N---------------------------------------------
Roco8_Ddis      --------------I---------------------------------------------
Roco9_Ddis      --------------L---------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      --------------------------------S---------------------------
LRRKb_Spur      --------------------KLCS-------QYVKSSPNSTIVLMILMCSPFIMDFATLS
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   CNHEDCYYNSLYSFNV----DT--------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   --------------VI--------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   --------------VLASPAEFI--------NAMKTSKAEE--MLVYACGKL-------A
AqueK495_Aque   -------------------------------SI---------------------------
AqueK496_Aque   -------------------------------DH---------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      TEIPPGAVAS---TLQEYHAHAQVLQVMDQHTYNADIQEAGCNALAA-------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   QAL-DDD-NPELADVKEEEVIRVTYQMMINHPLNSNLLQLACEVFLRCNSKAAYRGIVEE
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      -------------------------------------------LGVHQLILKMLTVHNAS
LRRK1_Hsap      -----------------------------TEGIRAAYR--RGDR----------------
CG5483_Dmel     -----------------------------REE----------------------------
LRRK2_Mmus      -------------------------------------------LGIHRLILKMLTVHHAN
LRRK1_Mmus      -----------------------------MEEIHTAYK--QRNL----------------
T27C10.5_Cele   -----------------------------VEL----------------------------
GbpC_Ddis       -------------------------------------------Y----------------
Pats1_Ddis      -------------------------------------------F----------------
QkgA_Ddis       -------------------------------------------I----------------
QkgA_C2d_Ddis   -------------------------------------------I----------------
Roco10_Ddis     -------------------------------------------L----------------
Roco11_Ddis     -------------------------------------------V----------------
Roco4_Ddis      -------------------------------------------I----------------
Roco5_Ddis      -------------------------------------------V----------------
Roco6_Ddis      -------------------------------------------I----------------
Roco7_Ddis      ---------------FC--------------------RS--SST----------------
Roco8_Ddis      -------------------------------------------F----------------
Roco9_Ddis      -------------------------------------------F----------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      -----------------------------SDSVKEAYKYMQALP----------------
LRRKb_Spur      -------------------------MMQVSD-----------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   -----------------------------FER----------------------------
AqueK486_Aque   -------------------------------------------FKWKKLSPIYTTSHHGP
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ---------------WC--------------------KE--GNT----------------
AqueK491_Aque   ---------------AA--------------------MW--GDV----------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   YAVFRTQSDWSIATLYCKELSQSQAYLDIAG-----------------------------
AqueK495_Aque   --------------------------------LPLL--HP--------------------
AqueK496_Aque   ----------------------------------ME--YGR-KT----------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   -----------------------------SERLPRLLS--R-------------------


LRRK2_Hsap      VNLSVIGLKT-----LDLLLTSGK------------------------------------
LRRK1_Hsap      ------G-----------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      VNLSIVGLKA-----LDLLLDSGK------------------------------------
LRRK1_Mmus      ------S-----------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------G-----------------------------------------------------
Pats1_Ddis      ------G-----------------------------------------------------
QkgA_Ddis       ------G-----------------------------------------------------
QkgA_C2d_Ddis   ------G-----------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------G-----------------------------------------------------
Roco4_Ddis      ------G-----------------------------------------------------
Roco5_Ddis      ------G-----------------------------------------------------
Roco6_Ddis      ------N-----------------------------------------------------
Roco7_Ddis      ------Q-----------------------------------------------------
Roco8_Ddis      ------G-----------------------------------------------------
Roco9_Ddis      ------G-----------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------E-----------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   MMKAYCGMVAIKVNGEDYLVVIGGLGPMASSNNTPPQPGAQYSGGGFITYQRCNEIHFYK
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------G-----------------------------------------------------
AqueK491_Aque   ------A-----------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------S-----------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ---------------------RSD------------------------------------
Pats1_Ddis      ---------------------RSDFD--------------------PSQF----------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ---------------------------SPPPPLPTQTINTSSSPPPPTI-----------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      -----------------GWVGN-LTEPTPP------------PPPPPSSVSAQSTAEANA
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   LSTGQWISPTVTGDRPPP------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ----------------------------------------------------G-------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ----------------------------------------------------R-------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      -----------------------------------QLIV-------------PQKTATIS
QkgA_Ddis       ----------------------------------------------------S-------
QkgA_C2d_Ddis   ----------------------------------------------------S-------
Roco10_Ddis     --ITTTTTTTTTTAMSPVATTTTSSPTISASPTYITSPSGTRLSGGNTFNAQQ-------
Roco11_Ddis     ----------------------------------------------------P-------
Roco4_Ddis      ----------------------------------------------------P-------
Roco5_Ddis      ILLNPTTQENHKK-----------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ----------------------------------------------------K-------
Roco8_Ddis      ----------------------------------------------------NC------
Roco9_Ddis      ----------------------------------------------------TS------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ----------------------------------------------------D-------
LRRKb_Spur      ----------------------------------------------------K-------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ----------------------------------------------------L-------
AqueK490_Aque   ----------------------------------------------------R-------
AqueK491_Aque   ----------------------------------------------------L-------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ----------------------------------------------------V-------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ----------------------------------------------------A-------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------ITLLILDEESDI------------------------------------------
LRRK1_Hsap      ---ARD-----------LLE-----------------EAC------------DQCASQLE
CG5483_Dmel     ---VRQ-----------I-----------------------------------------K
LRRK2_Mmus      ------LTLLILDEECDI------------------------------------------
LRRK1_Mmus      ---ARD-----------LLR-----------------GVC------------EESESSQE
T27C10.5_Cele   ---LAD-----------LFK---------VN--------------PWVW------NRVDR
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      FHVLSD-----------LN-----------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ---VRD-----------KLFPFY-----SHHSLGIERAMCGNQTLKEMPGRSDQE-ELYA
LRRKb_Spur      ---LKD-----------LVH-KKNIHSQV-------------------------LEIMDK
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ---KR------------------------------------------------------E
AqueK486_Aque   ---IYDFTLTSINNSSAI------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   -----D-----------LAQ-YW-----V-------------------------EENKDK
AqueK489_Aque   ---LEK-----------LL-----------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ---LES-----------LL-----------------------------------------
AqueK492_Aque   ----PEILFNLLNNRR--------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ---LRN------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ---LQK-----------II----------------------NHP------------IQRY
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ---------------------------------------------------------KDD


LRRK2_Hsap      ----------------------------------FMLIFDAMHSFPANDEVQKLGCKALH
LRRK1_Hsap      KG----------------------------------------------------------
CG5483_Dmel     HG----------------------------------------------------------
LRRK2_Mmus      ----------------------------------FLLIFDAMHRYSANDEVQKLGCKALH
LRRK1_Mmus      KG----------------------------------------------------------
T27C10.5_Cele   HG----------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      -------------------KSLSSYNI--KNNDELIFKKRQKKTNPGN------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      RF----------------------------------------------------------
LRRKb_Spur      HKDDPKVQASAMKTIAFLA-MAEDTCIAMLGEDVMEAILEAMKLFPGNAPVQK-------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   AG----------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   PGDV--------T-----------------------------------------------
AqueK489_Aque   -------------------IKVSSFHQQLPD---DLFKWGQ---TMLN------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   -------------------SNGA-----DP-------NLPN---SQGN------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   NLSDVYIVTGSTAALSYVLRDHMFAHINLLQLNFHSILFDVLKLHSSNPEIVC-------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   NG----------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   RG----------------------------------------------------------


LRRK2_Hsap      VLFERVSEEQLTEFVENK----DYMILLSALTNFKDEEEIVLHVLHCLHSLAIPCNNV--
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      VLFERVSEEQLTEFVENK----DYTILLSTFGSFRRDKEIVYHVLCCLHSLAVTCSNV--
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   -LFGGSTTN--------RLSNNVYIL--------------------NFTDTSVNCSKLSN
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ---------------EVLMSGNVRCYNI---------------------------V----
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ---------------EVLMSGNVRCYNL---------------------------V----
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ----------AK---LVSKKKPESIFKTLF----------------------SMSTLEMK
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      -------NACNALKQL--LTDEDCY-DVLLQ-----------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   PGGTVQWPKGRHAHSSVLISTSLGPYLL---------------------------V----
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ----------STLLKSTQFGNR--------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ----------TALHVACYYGERECA-SILLHYKAEVNAKGAEGKIPLHRAVLGVCVLE--
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   -------NVFLVFRLI--STEDRCK-QVLLE-----------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      LGEDKSAPEIS----EVENQIDDLGILFK-ALEI-------------------------L
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      -------PDIK----TREDAIKLGQTLFD-A-----------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   -----PGPKYQSREQISENQIDLVKLLVGNGSKVTFHDGYGDTPYDAALQCDFYECAELL
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      TNSFNQNKDIEDIV----------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------ET-HKDII----------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   -------------VGGAGTDDIWIFNINNKSWKEQEQVNLPDNATDRCYHSLSVWSVTPT
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ----------SDLA----------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------SSLFQLSL----------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------VEAMKA--FPMSERIQEVSCCLLHRLTLG---NFFNILVLNEVHEFVVKAVQQY
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------VEAMKA--FPTNENIQEVSCSLFQKLTLG---NFFNILVLNEVHVFVVKAVRQY
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------RY----------------------------V-----------
Pats1_Ddis      -------SSFQ--YVGNESE----------------------------I-----------
QkgA_Ddis       ------------------------------------------------K-----------
QkgA_C2d_Ddis   ------------------------------------------------K-----------
Roco10_Ddis     ------------------------------------------------L-----------
Roco11_Ddis     ------------------------------------------------L-----------
Roco4_Ddis      ------------------------------------------------M-----------
Roco5_Ddis      ------------------------------------------------A-----------
Roco6_Ddis      ------------------------------------------------I-----------
Roco7_Ddis      ------------------------------------------------I-----------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      -------AAIKR--FPDNVGLQTACCALIEALAQTE--DSQQLFVLNDV-----------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   TNWIIVF-----------------------------------------------GGSTLY
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------L-----------
AqueK491_Aque   -------NAYDACKVGDLTK----------------------------V-----------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   -------EYLQS--YQEDVPVVTSLCSVIESLASTESTDFMELAASVPL-----------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      PENAALQISALSCLALLTETIFLNQDLEEKNENQENDDEGEEDKLF--------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      PENAALQISALSCLALLTETIFLNQDLEERSETQEQSEEEDSEKLF--------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ---------------------------------------------KQFLNKN--------
Pats1_Ddis      ---------------------------------------------ADLVKIV--------
QkgA_Ddis       ---------------------------------------------KDLIVNS--------
QkgA_C2d_Ddis   ---------------------------------------------KDLIVNS--------
Roco10_Ddis     ---------------------------------------------KSLLLA---------
Roco11_Ddis     ---------------------------------------------KDLLVRV--------
Roco4_Ddis      ---------------------------------------------KDLIISV--------
Roco5_Ddis      ---------------------------------------------MDFWVTN--------
Roco6_Ddis      ---------------------------------------------NSLLLND--------
Roco7_Ddis      ---------------------------------------------TDLINSL--------
Roco8_Ddis      ----------------------------------------------GIICNV--------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ---------------------------------------------SDLLIDALR-RFSDN
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   TDTAVIELRYTSNNDWFTSIIPLDQYQEKLQ-ERRNEDKIEIDHLT--------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ---------------------------------------------RDFLYHE--------
AqueK491_Aque   ---------------------------------------------KELMPGI--------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ---------------------------------------------SSLVYSSLQLHYKES
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      -----------------------------------WLEACYKALTWHRKNKHVQEAACWA
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      -----------------------------------WLEPCYKALVRHRKDKHVQEAACWA
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ---------------------------------------SNIPIPPVPTSPTSTPPNLQT
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ---------------------TSTTTTTTTTTSSN-NIPSLVSV----------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ARYLTICLSVMDRLAEAIFTAPKW--LDRMLNDNW-MNETFMALTKHQDSPPCLENALRA
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ----------------------------------HLLQERERELEEERREK---------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ---------------------PNAQAYF--------------------------------
AqueK491_Aque   ------------------------VVMI--------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   VQLCAYGFSLFSYLSSRLPLITNHLRLEDLL--RF-MS---SVFEVHGSDTEFQEAFCRC
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      LN-----------------------------NLLMYQN-SLHEKIGDEDG----------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      LN-----------------------------NLLMYQN-SLHEKIGDEDG----------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     NN-----------------------------NNKQ-------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      LT-----------------------------TLVSNRPGMLVEMLTEESE----------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   -EQVRNRLQQQFQGRERQLQQAQQQGQERERQAREQVQ-DLHRQLREKER----------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   -------------------------------NTKM-------------------------
AqueK491_Aque   -------------------------------NECK-------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   LG-----------------------------GLFEASP-QLHMFVGEGGGGGGEGGGGGG
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------HFPA-----------HREVMLSMLMHS-SS------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------QFPA-----------HREVMLSMLMHS-SS------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------SMAV-----------DSAVLMSLRLHSKNS------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------EFQE-----------REQQLLRQVEGG-QQREQDLQRQLQLREQQLEEREREFQ
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   GGNEESSLSTAGEIRVPIINWIWVVLLSNLSDT-QQ------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      -----------------------------------------------KEVFQASANALST
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      -----------------------------------------------KDVFQAAAHALST
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      -----------------------------------------------KIIFEMGCDAIQA
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ERERQFEEQIQVAESSWVVNRREITMTEVVLGKGGWGEVKVAGFRGLKVAAKCLYEVIIS
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   -----------------------------------------------YKVFESVCLAVYY
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      LLEQNVNFRKILLSKGIHLN----------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      LLEQNVNFRKILLAKGVYLN----------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      LAENSDMMQRTLAEKGALMDIRSGMVT--YARSP---ECQAAASRAIRGLCLAIEYRDDS
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   PYNIEIFSRE--------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   LGVDSDRLRKLLLDKGGASAIFEGLRRFKGIQEPRFERCLQYGCRALLALIMS---PGS-
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ----------------VLELMQKHIH----------------------------------
LRRK1_Hsap      ---------------QL-------------------------------------------
CG5483_Dmel     --------------E---------------------------------------------
LRRK2_Mmus      ----------------VLELMQKHAH----------------------------------
LRRK1_Mmus      ---------------QL-------------------------------------------
T27C10.5_Cele   --------------RTP-------------------------------------------
GbpC_Ddis       ---------------LL-------------------------------------------
Pats1_Ddis      ---------------LS-------------------------------------------
QkgA_Ddis       ---------------MK-------------------------------------------
QkgA_C2d_Ddis   ---------------MK-------------------------------------------
Roco10_Ddis     -----------DK--DK-------------------------------------------
Roco11_Ddis     ---------------MK-------------------------------------------
Roco4_Ddis      ---------------MN-------------------------------------------
Roco5_Ddis      ----------------Q-------------------------------------------
Roco6_Ddis      ---------------LN-------------------------------------------
Roco7_Ddis      ---------------IV-------------------------------------------
Roco8_Ddis      ---------------TS-------------------------------------------
Roco9_Ddis      ---------------KK-------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ---------------GF-------------------------------------------
LRRKb_Spur      IHLDNKQAVTEAGIHTL-------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   --------------N---------------------------------------------
AqueK486_Aque   -----------------MNIASKLRHPNLLQFIGATTEVMAGVFRGVFQDDANLHKFCHD
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   --------------TFL-------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   -----------TKGNTL-------------------------------------------
AqueK491_Aque   -----------KEYMTL-------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   --------------RTL-------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   --------------YTL-------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ---------------------------------LSI------------------------
CG5483_Dmel     ---------------------------------LRT------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ---------------------------------LSI------------------------
T27C10.5_Cele   ---------------------------------LML------------------------
GbpC_Ddis       ---------------------------------KKK------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ---------------------------------DEK------------------------
Roco7_Ddis      ---------------------------------ILD------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ---------------------------------LHA------------------------
LRRKb_Spur      ---------------------------------LFEAVRNFIGDVEVLLDIVNTITCLAD
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   GKIEKIMDFVATVEPEILLDRLNNRRGISGYTPLHE------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ---------------------------------LFP------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ---------------------------------IHE------------------------
AqueK491_Aque   ---------------------------------LMI------------------------
AqueK492_Aque   --------------------------GVFGYTPLHE------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   -----------------------------------SGMKDFLVQVEA-------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ---------------------------------VHI------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ---------------------------------LHY------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      MDVVKYQCMVEGIHEVILQGMAEYQDDPNIQELFLETMVVLSSAEGMIDILVEAGILSLT
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      VELMEKYSQIEAIQENGTILLQTVVNKKKSICDDRLAEKIARAIISSMKKFRKAPSILAE
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ----------------------------------------IYDLIDILDNHTAAPDIAAE
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      SCVAMQFLADISQEVTKTLVNYNAHEELFHILEAYKDDDTLVNLVCECLYILCCKWEFTD
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ALGV-----------------------MACLSDNGRFRAAAIQQN---------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ----------SPEVAESGCKMLNHLFE-GSNTSLDIM----AA--------VVPK-----
LRRK1_Hsap      -----PAAYGD-------LEMVRYLLSKRLVELPTEPT----D--------DNPA-----
CG5483_Dmel     -----AVISGD-------ERTVRVLLAALGT------------------------ERQ-I
LRRK2_Mmus      ----------APEVAESGCKMLSHLFE-GSNPSLDTM----AA--------VVPK-----
LRRK1_Mmus      -----AAAHGD-------LETVQFLLTEKRVELPTEPT----D--------DNPA-----
T27C10.5_Cele   -----AAHNGK-------LDSLRTILMLSPN-----------------------------
GbpC_Ddis       -----DGTLGT-------AEELLTLIQQSNINVVTAST----------------------
Pats1_Ddis      -------------------------------------------------------NNDGL
QkgA_Ddis       -------------------------------------------------------NH---
QkgA_C2d_Ddis   -------------------------------------------------------NH---
Roco10_Ddis     -------------------------------------------------------DN---
Roco11_Ddis     -------------------------------------------------------NI---
Roco4_Ddis      -------------------------------------------------------SL---
Roco5_Ddis      -------------------------------------------------------NN---
Roco6_Ddis      ---------------------------------RTTST----------------------
Roco7_Ddis      -----DSF----------LELLRLFIKQTIDQAKQCST---DE--------SNPLNY---
Roco8_Ddis      -------------------------------------------------------GA---
Roco9_Ddis      -------------------------------------------------------DK---
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      -----SCKKGD-------VDAAHMLMCWGIEPCCKNTE----G--------RSAL-----
LRRKb_Spur      QMLLWACKENL-------MKGVEVLVELGADVN-----TGEGY--------ETPM-----
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------QRYITGSVKMCGR------------------------EV---
AqueK486_Aque   -----AVSGNR-------YEVISYLVELGANVNARAN----FG--------YTPL-----
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   -----AAKAGQ-------PDTLEKFIRYGDLSQIEKDDKSHLG--------WNIY-----
AqueK489_Aque   -------------------HVVSLLIKFGANNYKECID---S------------------
AqueK490_Aque   -----AVENGQ-------PDVLQLLLQNGI-SSETKGK---NN--------QTPL-----
AqueK491_Aque   -----ASREGH-------SAIVDYLIDIGAKVTHTLGS---TA--------KTAL-----
AqueK492_Aque   -----AVSGNR-------LKVIPYLIEQGANVNAKAN----SG--------YTPL-----
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   -----------------------------------------VHARVLNLIQYKPT-----
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   -----AADKGL-------SEYLEKLLLEGGDPNKPSSV-PDLC--------QTPL-----
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   -----AAERDR-------PESLKILLINGADPNIRTSH-NSFE--------ITPL-----


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      SSNSNNNSSSNIGSMLNSGGGGSGSNLGLGLSSGTGGSFNGNSSGSSSSSSYYYNNNNNN
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     --------------IVNMA------------PS---------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   --------------SLNLV------------ND---------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      NNIELTAQQKNPKVLCSFI------------LH--LLQ----------------------
QkgA_Ddis       ------------ETTLTII------------NE--TYR----------------------
QkgA_C2d_Ddis   ------------ETTLTII------------NE--TYR----------------------
Roco10_Ddis     ------------ETFATLI------------NE--ELP----------------------
Roco11_Ddis     ------------NTPFKIL------------NE--TFK----------------------
Roco4_Ddis      ------------DTTFKII------------NE--TYR----------------------
Roco5_Ddis      ------------NTSNNNI------------NN--NNK----------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------QSFYNLI------------NR--MAA----------------------
Roco8_Ddis      ------------D---PIF------------KD--DYI----------------------
Roco9_Ddis      ------------EK--KILQQLQQQQDDEQQQQQQQFMEGDNNNNNTNSLNTPSVEGDSE
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   --------------PVKIV-----------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------ILTVMKRHETSLPVQLEA------------------------
LRRK1_Hsap      ------------------VVAAYFG-------HTAV------------------------
CG5483_Dmel     ------------GANTLLFLACQSG-------YESI------------------------
LRRK2_Mmus      ------------------ILTVMKAHGTSLSVQLEA------------------------
LRRK1_Mmus      ------------------VVAAHFG-------HAEV------------------------
T27C10.5_Cele   ------------RGKTALHMAAESG-------ETSI------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      -----------I------------------------------------------------
QkgA_Ddis       -----------I------------------------------------------------
QkgA_C2d_Ddis   -----------I------------------------------------------------
Roco10_Ddis     -----------L------------------------------------------------
Roco11_Ddis     -----------I------------------------------------------------
Roco4_Ddis      -----------I------------------------------------------------
Roco5_Ddis      -----------TSNTTGSNVSSSNN-------KETVKINVTSLDSGGNNNASGKDISNEH
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      -----------I------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      NINRLAASTNST------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------EIATTEG-------HLNI------------------------
LRRKb_Spur      ------------------CFACEN------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   -------------------EEPELT-------TRAI------------------------
AqueK486_Aque   ------------------HLAASAG-------HIEC------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------HYAVY-------------------------------------
AqueK489_Aque   --------------------SRQNN-------HI--------------------------
AqueK490_Aque   ------------------HIAAAKG-------HVDC------------------------
AqueK491_Aque   ------------------HYAAENG-------HADV------------------------
AqueK492_Aque   ------------------HLAAIVG-------HIEC------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------HSVLVE------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------HLAAFQG-------YAKC------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------HIAAANG-------HLDC------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ---IFSQTSLTYSLYITY------------------------------------------
QkgA_Ddis       ---V-------------Y------------------------------------------
QkgA_C2d_Ddis   ---V-------------Y------------------------------------------
Roco10_Ddis     ---T-------------TEE--KENIKAQKKD---------------------------L
Roco11_Ddis     ---N-------------Y------------------------------------------
Roco4_Ddis      ---V-------------Y------------------------------------------
Roco5_Ddis      SPKN-------------RKEKEKEKDKDNKEDSINESPVDENRRKLVEGFMKSLQGCSDA
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ---Y-------------L------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ---S-------------Y------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      VQE---------------------------------------------------------
CG5483_Dmel     TQRLLDAGADGRSHAVTKYSP---------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      VRE---------------------------------------------------------
T27C10.5_Cele   VLELVELGSDPMKSDNEGHCA---------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ISS---------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      IKV---------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ITE---------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   L-----------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   -TA---------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   IKT---------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ----------------------------------TLLMEDIGP------LPDGVIKDNS-
AqueK496_Aque   LQVLVKHGAQIRVQNAHRTTPIDLVRGK--TVCESILQEAIGKVEVPNRTQDQLQR--V-
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   LKRLVESGGDPLLRDSKNRLPRDHAQGNRQELCLEYLQKESA-----TVIKSGI-SEPLT


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   --LAVIVLFC----------------NKKE------------------------------
AqueK496_Aque   --MDLHRLID----------------QQRE------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   TIFYLVIMADVSEYLEAGDFESLFNYDNFNKSFPLDSSKPTPTTPEDNIIERQEIHTFIL


LRRK2_Hsap      -------------------------------------------------------LRAIL
LRRK1_Hsap      ----------------------------------------------------------LL
CG5483_Dmel     -------------------------------------------LYAAVHSGHLGIARLML
LRRK2_Mmus      -------------------------------------------------------LRAIL
LRRK1_Mmus      ----------------------------------------------------------LL
T27C10.5_Cele   -------------------------------------------LELAQMAGHNEVAAKLI
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ----------------------------------------------------------LP
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ----------------------------------------------------------I-
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ----------------------------------------------------------LV
LRRKb_Spur      --------------------------------------------------NNVDMVKQLL
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   -------------------------------------------------------VKALL
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   --------------------------------------------------GYQINCSYLL
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ----------------------------------------------------------LI
AqueK492_Aque   -------------------------------------------------------VRVLL
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   --------------------------------------------------SAI---ELLI
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ----DMDTFM---SLYSRLSALETDLSTRWTDW-----FQQTLLYRAADKDHVQIVTFLL
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   NTYTKHCNLLNNSTLVHSL--------SRFTRDFPISLHYVTILHAAVQYNHISLVSFLV


LRRK2_Hsap      ----H---------FIVP------------------------------------------
LRRK1_Hsap      ----E---------SL-P------------------------------------------
CG5483_Dmel     ----D-------------------------------------------------------
LRRK2_Mmus      ----H---------FVVP------------------------------------------
LRRK1_Mmus      ----E---------SL-P------------------------------------------
T27C10.5_Cele   ----D---------AI-Q-KES--------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     EVPL--------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ---LD---------VF-Y------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ----K---------ID-E------------------------------------------
LRRKb_Spur      ----K---------QG-ISDLHTPLSRCLKLKQHHIIGLLLYQMGCDRQAGSLTWSSLGL
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ----Y-------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ----N---------EK-SQAST--------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ----K---------RL-P------------------------------------------
AqueK492_Aque   ----D-------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ----IFAQLDEKVHTV-FNE----------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ----Q---------QS-PAQPL--------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ----S---------NY-P------------------------------------------


LRRK2_Hsap      --------------------------------------------GM--------------
LRRK1_Hsap      --------------------------------------------G---------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      --------------------------------------------GL--------------
LRRK1_Mmus      --------------------------------------------G---------------
T27C10.5_Cele   --------------EDLNEAHTMIISACISGSADVVYE-ISR---RFMEKSGKQSREILF
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      --------------------------------------------QP-LKKADLLSQ----
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      --------------------------------------------G---------------
LRRKb_Spur      ARLNPEWLYKVFLDEEPPDPDSPND-----VVKYQCMVEGIHEVI---------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   -------------------------------------------------------SIILF
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   --------------ANLT-PDEARQ-----I-----------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   --------------------------------------------R---------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   --------------------------------------SGIFREL---------------
AqueK495_Aque   --------------HKEE-EQKTINTNDATDEIELFFKAFSDKPK---------------
AqueK496_Aque   --------------SNLGHGDTPLMIACRHSNLKLVDLLINHSPG---------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   --------------------------------------------S---------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   NGRNEEDETA--------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      --------EELKAIFSLIESISSFQQTILIDFKKYISNWNSTTQAQLHSTFLQFVGYLKL
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      --------------------------KSQLGGLMEKT---------MISQVLNFTPMIQE
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      -----------------------------------------------------SSLRSSS
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   DITSHETYME--------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      --PEESREDTEFHHKLNMVKKQCFKNDIHKLVLAALNRFIGNPGIQKCGLKVISSIVHFP
LRRK1_Hsap      -PC---------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      --LEESREDSQC--RPNVLRKQCFRTDIHKLVLVALNRFIGNPGIQKCGLKVISSLAHLP
LRRK1_Mmus      -PC---------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      YKV---------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      QIV---------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      TRS---------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      -LL---------------------------------------------------------
LRRKb_Spur      -LQ---------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   -----------------------------CSADISLIDSRGKTPKQTADLKKKSNVVRLL
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   -IL---------------------------------------------------------
AqueK492_Aque   -----------------------------CSADVSLTDDYGKTPRQTASLGKNSNIVRLL
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   -IA---------------------------------------------------------
AqueK495_Aque   -LF---------------------------------------------------------
AqueK496_Aque   -LI---------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   -LL---------------------------------------------------------


LRRK2_Hsap      DALEMLSLE-GAMDSVLHTLQMYPDDQEIQCLGLSLIGYLITKKNVFIGTGHLLAKILVS
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      DATETLSLQ-GAVDSVLHTLQMYPDDQEIQCLGLHLMGCLMTKKNFCIGTGHLLAKILAS
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   RSEEIIKEAKTKGDNLTELLEVRIDDLE--------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   RSKEIIKEVKTNGDNLTELLRVRIDDLE--------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      SLYRFK------------------------------------------------------
LRRK1_Hsap      -----S------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      TLQRFK------------------------------------------------------
LRRK1_Mmus      -----T------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------L-----------------------------------------------------
QkgA_Ddis       ------Y-----------------------------------------------------
QkgA_C2d_Ddis   ------Y-----------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------C-----------------------------------------------------
Roco4_Ddis      ------F-----------------------------------------------------
Roco5_Ddis      -----YG-----------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      -----IL-----------------------------------------------------
Roco8_Ddis      ------F-----------------------------------------------------
Roco9_Ddis      -----ID-----------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      -----E------------------------------------------------------
LRRKb_Spur      -----GMAEYQDDPNIQELFLETMVV---LSSAEGMIDILVEAGILSLTVELMEKYSQIE
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   -----LY-----------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   -----ILDRNMGESITYKCL-----MLIHILADED----------------HLSTYPRDC
AqueK495_Aque   -----VIGDNKPDTCQ----------------WPEAAQFVML------------------
AqueK496_Aque   -----FI-----------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   -----T------------------------------------------------------


LRRK2_Hsap      ---------------------------------------------DVAEIQTKGFQTILA
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ---------------------------------------------DVAEVQTTGLQTTLS
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      AIQENGTILLQTVVNKKKSICDDRLAE----KIARAIISSMKKFRKAPSILAESCVAMQF
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   --------------------------RKIAWSLCSLLAPTQQSPTLTIEARIATAITLTF
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ILKLS-------------ASFSKLLVHHSFDLVIFHQMSSN-------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ILELS-------------VSFSKLLVHYSFDVVIFHQMSSS-------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ----------------------------------------------------LLIEISHF
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ----------------------------------------------KTN-----------
QkgA_Ddis       ----------------------------------------------DQY-----------
QkgA_C2d_Ddis   ----------------------------------------------DQY-----------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ----------------------------------------------DQQ-----------
Roco4_Ddis      ----------------------------------------------DTD-----------
Roco5_Ddis      ----------------------------------------------LQY-----------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ----------------------------------------------ANK-----------
Roco8_Ddis      ----------------------------------------------YQF-----------
Roco9_Ddis      ----------------------------------------------YNP-----------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      LADIS-------------QEVTKTLVNYNAHEELFHILEAY-------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ----------------------------------------------------L-SQLLEM
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------QLDIIYLLHQ-HKAPVT---AGLDIEQEDI
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ----------------------------------------------EE------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   LIHIDALVCACSLCKSCPNLMPQILVEFAVDTNIFRLLYSKPLEDLQFDNTD--------
AqueK495_Aque   --------------------------------------------DDITQP----------
AqueK496_Aque   ----------------------------------------------SEDQ----------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   SFEICFHKNLFQCLHKRSYRNRPSLITIRRASSTKPRIQGYSNPCGSVVTECGSVAAVFG
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------KDDDT-LVNL--------VCEC--------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   SHRVCPSAHVVVI-GAKADLRKP------HHVTTE---EAESFC----------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   LHPLPLHPSLMALGFECSFSEAAILIDMLSLSSSTAGSNGVG-----------------S
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ----TDNPEQL-IYEL--------AIDV--------------------------------
AqueK495_Aque   ---EELNKLF----------KTIILEPLLFS-----------------------------
AqueK496_Aque   ---NSLSPLHVS----TSRGDKGIVQSMLDA-----------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     -------------------------------------------HFPEL----------IQ
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   VS-PSPVSNGGPFRDGEELENRRNRAFDISLWCLKILKLQIFQKFPQL----------VK
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      --------------------------------------------LYI----------LCC
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   HSAS----------------------------------------TPG--LDNIKVTSNND
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   --------------------------------------------VHS----------LSL
AqueK495_Aque   --M---------------------------------------------------------
AqueK496_Aque   --VQ------------------------------------------GLYEKGITHRDLNL
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      PQRL--------------------------------------------------------
CG5483_Dmel     QPTV--------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      PQRL--------------------------------------------------------
T27C10.5_Cele   STNN--------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ---N---------NNNNNNNNNSSSPSNTDL-------------SRSTYFYDIP-VKSRI
QkgA_Ddis       ---E--------------------------------------------------------
QkgA_C2d_Ddis   ---E--------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ---E--------------------------------------------------------
Roco4_Ddis      ---E--------------------------------------------------------
Roco5_Ddis      ---N--------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ---EAN----KNN-----------------------------------------------
Roco8_Ddis      ---DNN----KNNNNINNNNNNATSTATT-------------------------------
Roco9_Ddis      ---SNNGGNGGIRSDSFYSQTSESSDITSTSTTSPTMSAASSSSSSGTVKTPKPPKSSKL
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      DVAE--------------------------------------------------------
LRRKb_Spur      KWEF--------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   HRRA--------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ---S--------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   KEDC--------------------------------------------------------
AqueK495_Aque   TQTD--------------------------------------------------------
AqueK496_Aque   TDKI--------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   QPSS--------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ILKHIMLFLYNLTQRDASLLDSLSNIIGPFILGNVLLDPPPPPPSNSSPPISKSTS-NNN
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------ATAPITPVSTKIGSIGKSSS----
Roco9_Ddis      --KHIYNSLKFKSLKTEKNGSSSSIKSNISNFEFIMPNTPLPIFDQQSPPIHF-YNSNQ-
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      LNV---------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      FSDFQYFGTPLYSLIKRQDNGLSIPILLEKSISFLEGHCHVEDLFFRKYNNEKVKFMRNS
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      FERTGDFNFYYPDPQDPYDVAALLVEFIASLPDQLLNVELYNAIKNHTSALNSQYGGYWD
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ----------------------------------------LN-WM---------------
CG5483_Dmel     ----------------------------------------ERWLP---------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ----------------------------------------LN-WM---------------
T27C10.5_Cele   ----------------------------------------EGSTC---------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ---------------------------------------SN-YHNNNNNNNNSNSNLSNS
QkgA_Ddis       ---------------------------------------SK-FTS---------------
QkgA_C2d_Ddis   ---------------------------------------SK-FTS---------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ---------------------------------------TK-TKSS--------------
Roco4_Ddis      ---------------------------------------TK-LTSSNLDS--DDEEFESD
Roco5_Ddis      ---------------------------------------YS-LSS---------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      IQYLAQKLSVESREFLQRLLFFLKKHVSACLFKQQQQQQQQ-RES---------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ----------------------------------------LK-LL---------------
LRRKb_Spur      ----------------------------------------TD-QM---------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ----------------------------------------LY-HL---------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ---------------------------------------PK-GSS---------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ----------------------------------------RQ-KM---------------
AqueK495_Aque   ----------------------------------------ID-KV---------------
AqueK496_Aque   ----------------------------------------GR-TP---------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ----------------------------------------EGYTA---------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      --------------LALACQRGHLGVVKLL------------------------------
CG5483_Dmel     --------------LHAACINGHIKLLELLISYSYPDYLYQTYRDEEG------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      --------------LALACQRGHLEVVKLL------------------------------
T27C10.5_Cele   --------------LHWAARCGSSECVSTILNFPFPSE-FIIEIDTVG------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      GNGDESPDFQSQNLVKSYN-----------------------------------------
QkgA_Ddis       --------------CNIIT-----------------------------------------
QkgA_C2d_Ddis   --------------CNIIT-----------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     --------------FYIQT-----------------------------------------
Roco4_Ddis      DDADEEADLQIQASCNLYT-----------------------------------------
Roco5_Ddis      --------------LCLLM-----------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      --------------NNVLS-----------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      --------------TEVL------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      --------------VCRACKAGKKEIIDYWF-----------------------------
LRRKb_Spur      --------------LLWACKENLMKGVEVL------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   --------------FEWAYNRGHLDVLTFC------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   --------------LHLAA-----------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   --------------LISAVKHSMIEAIKLL------------------------------
AqueK495_Aque   --------------SSLACVKGESNTLKLFLGLH---------------------QTPPT
AqueK496_Aque   --------------FYNACYHGQLPIVKAFLEFK---------------------AKFPD
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   --------------LHVAVSHKCFEIVQILTEAY-MNI-YRQRS---SSVALAMGGANPR


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     --QWEWR-----------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   --APAYQ-----------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------RE-----NSGNSLNSMLHQTSLPNNNNS--------------------
QkgA_Ddis       ------------FDGKDKRS-------------------IK-------------------
QkgA_C2d_Ddis   ------------FDGKDKRS-------------------IK-------------------
Roco10_Ddis     ------------FISPSPTL-------------------SRNNNGKRNSGGNKPPLSPIK
Roco11_Ddis     ------------LDANDKSS-------------------LE-------------------
Roco4_Ddis      ------------FDGKNRQS-------------------VD-------------------
Roco5_Ddis      ------------FDNQRFES-------------------FINNAESKLVNEHKYSLAPLV
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------ANSTPNV---------------------T-------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ----------------------------------------T-------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------RNG-HADT-------------------VK-------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   N-------TWL-------------------------------------------------
AqueK496_Aque   K-------IDINA-----------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   IRAPPSEAPLLFS-----------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ---------------------------------------------------------GG-
Pats1_Ddis      ------------------------------------------NVV-----NNNNNNNNNN
QkgA_Ddis       ------------------------------KM---------KRVV-----QKLSNESTN-
QkgA_C2d_Ddis   ------------------------------KM---------KRVV-----QKLSNESTN-
Roco10_Ddis     --ISSTSAAGDVSPSISLNNSGSGIYNSTSP--SGTASTQT-LNILSQLQQQQRNGNNNN
Roco11_Ddis     ------------------------------LT---------KSAI-----KNIQMQQQQQ
Roco4_Ddis      ------------------------------EI---------KRIV-----QHLNETQ---
Roco5_Ddis      PTSSSSSCVKPVSLSEI---------------------------LGSQYDQTTSQSTNNS
Roco6_Ddis      ---------------------------------------------------------NNK
Roco7_Ddis      ----------A--------------------LKTSPA-IGSPRII-----M--GSNYNNS
Roco8_Ddis      ------------------------------KS---------STAV-----DKMNNNNNNN
Roco9_Ddis      ----------LSLSSSTSTLEPEPQPLPLSTS---------TQRLPQQSSDDNSNNDNNN
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------VL---------LDVA-----SGLFPP----
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       AAMG-------------------------------AMLNHTVS-----------------
Pats1_Ddis      NNNNNNN----------------------------NNNNNNNNNN---------------
QkgA_Ddis       ---SSHQ----------------------------FD-----------------------
QkgA_C2d_Ddis   ---SSHQ----------------------------FD-----------------------
Roco10_Ddis     NNNNNNNYLSSPTMPALNKHSTHGNFHNSVAGYGNNNNNNNNNNKQPQHPMNGNHSPSNG
Roco11_Ddis     QQQQQQQ----------------------------QQ-----------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      SG---------SSFPAVTLRRTGHTFTGIN--SANSNNNNNNSG----------------
Roco6_Ddis      SNNN-------------------------------SNNNNNET-----------------
Roco7_Ddis      SNNNNI-----------------------------DSIDLNNNSP---------------
Roco8_Ddis      NNNNNN-----------------------------NNNNNNNNSN---------------
Roco9_Ddis      KNDNDN-----------------------------DNDNDNNN-----------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ----------------------------TPERK---------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      --------------------NNNNNNINNNSTSSNNNNNNNSNNNN-SQI--------P-
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     TSGSLSMSGSGIDNGGNNNNNSN--------------THGSSSNQ-SSGV----------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      -----------GGSSGINNSNS---------------------------VTGKFTQEYT-
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      --------------------NML--------------KNNSPSTFINGSV--------PQ
Roco8_Ddis      --------------------NSN--------------SNNNSSRRT-SSV--------P-
Roco9_Ddis      ----------------------D--------------N-NNINNDNGEII--------P-
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   --------------------------------------------DSSSLD----------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     --------LPFDA-----NAHDVTGQ----------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   --------LALDV-----NEVDGECR----------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      -----PLI----------------QVRQPSSDFTTTS-----------------SGNLRS
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      INGGGGSY----------------NLTPI-------------------------------
Roco8_Ddis      -----PPV----------------LVTAS-------------------------------
Roco9_Ddis      -----PSI----------------QVTPPTSPQTQPKQQQPPQPPQKTLIEKLSE-----
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   --------------------SGHRNG----------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   -------------------------F----------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   -----EPVLPPDASVNVFSHSQAEGR----------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   --------------------EEKSRR----------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   --------------------PTNTGH----------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     --------------TSLYIASILGN--KQLVGVLLKWQ----LHCRR-------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   --------------TAMYLAVAEGH--LEVVKAMTDFK----CT----------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      LSNTENSLCKKVAID------------------LIQNIPLYLLFSHLKIQQLEGEKILFS
QkgA_Ddis       ------------------------------------------LHSHA-------------
QkgA_C2d_Ddis   ------------------------------------------LHSHA-------------
Roco10_Ddis     ---------------------------------------TSP------------------
Roco11_Ddis     ------------------------------------------QQHHD-------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      -------------YS------------------NLASLLILPI-----------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   --------------TPYY------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   --------------LKICQAILDEE--EDVIDILLARN----------------------
AqueK490_Aque   --------------------------------------------LRA-------------
AqueK491_Aque   --------------TPLHEAVIGGH--TDIVSMFVKWIRENQLKKPV-------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   --------------SPLHAAVSAPKFSKEIVELLVK-EEELKLNIE--------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   --------------TPLHMSVALCE--REITLLFLSHAKQLSLSLE--------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------T------------LGDSASSVSTPITPTRKRISFGIQAIMSK
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      AENIFCVDKCNFPPNK-AMLGEIWVTNFRIIFINSN------------------------
QkgA_Ddis       ------------------L------------LQ-SS------------------------
QkgA_C2d_Ddis   ------------------L------------LQ-SS------------------------
Roco10_Ddis     ----------------------I--------IQ---------------------------
Roco11_Ddis     ------------------I------------FQ-FT------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ----------HFLARFHQFFKSL--------ID---------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      -------------------------------LS-SS------------------------
Roco9_Ddis      -----------------LFTPLF--------VN-YK------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------L------------LE-GG------------------------
AqueK491_Aque   ------------------A------------L--GL------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   -----------------------------------A------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   -----------------------------------G------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     LHISGESEGPDDLASQESTECQRCPINVNLLCGAARETALLAAVRGG-------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ----------------SIDGRQRCPFQLDVYCTR-GRTPFMLAAFNQ-------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------EIANG-------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   --------------------------------YPSSRSHKYIAKMLERKRSLTVFPSSSI
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   --------------------------------SACGYTALHLAVHFN-------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       -------------------------------------------------TINL-T-----
Pats1_Ddis      ----------------------------------SNSSTIPN----STSSTSI-------
QkgA_Ddis       ----------------------------------SSSSSS-S----TSSSPSL-------
QkgA_C2d_Ddis   ----------------------------------SSSSSS-S----TSSSPSL-------
Roco10_Ddis     ----------------------------------STSPQPPH----LTGLN---------
Roco11_Ddis     ----------------------------------QPSSSH-N----HS------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ----------------------------------SIAVLNPD----YKPYN---------
Roco6_Ddis      -------------------------------------------------LEDI-I-----
Roco7_Ddis      ------------------------------------SSPT-I----GSSTPTIITS----
Roco8_Ddis      ----------------------------------TSSSSSST----TSTSSSL-------
Roco9_Ddis      ----------------------------------THSAFYSS----TSTLITS--CEDIF
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ----------------------------------ADINST-DDFGNT-------------
AqueK491_Aque   ----------------------------------SPSSALS-----NSQVPVS-------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   AQTYRAYTSFDQIESDDPPSYRDDRGCDTPISTSSAISDDLDAEIGITKRESL-------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      VHIDERPITLPGEFIMMQIKNVIIPPTNLKLEHTISSSSKSDKNDKNDKNGNTDVTLWQS
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ----------------------------------------SSFASTQNLSILSIMTLFGS
QkgA_Ddis       ----------------------------------------T-------------------
QkgA_C2d_Ddis   ----------------------------------------T-------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ----------------------------------------S-------------------
Roco8_Ddis      ----------------------------------------A-------------------
Roco9_Ddis      GTLFITNYRMIWKKDESNSIDSESNSILLPEDIITPTQSFS-------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   -----------------------------------------VFSRAERSKRREPIQRLLK
AqueK491_Aque   ----------------------------------------P-------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ----------------------------------------P-------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ---------------------------H--------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ---------------------------N--------------------------------
GbpC_Ddis       -----------------------GSGSVPTYNPSDN----R-------------------
Pats1_Ddis      YNGNGGSGPTNATLSGGGSTSSSSNLNTPITTSP-------IH--TS-------------
QkgA_Ddis       -----------------------SSPSSPISTSP------PYH--SS-------------
QkgA_C2d_Ddis   -----------------------SSPSSPISTSP------PYH--SS-------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     -------------------------------NHH------HHH--HQ-------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      -----------------------EFNN-------NN----C-------------------
Roco7_Ddis      -----------------------SSTTTPTNNNN------SNN--NT-------------
Roco8_Ddis      -----------------------ST---NTNSNS-TYNSNSFNKKHHRYSI---------
Roco9_Ddis      -----------------------S-----INNNN-NNNSS------KFVEIKLYSFEIIL
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ---------------------------P--------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   SKELVLVAC---------------------------------------------------
AqueK491_Aque   -----------------------RTPTTPSSHGL------GLHA----------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   -----------------------HTPIS--------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ---------------------------Q--------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      TSIIKWESFGKSLKSTTPMMSTPTTFQNGGVNRSQFQIFLCYCKNIRFQYMGFSDESNFR
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     -L----------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   -L----------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      -TNSNGAILNPINNSLINSNNNNNNNNINNNINNNINNINNNINNINSNSNNNINSIINS
QkgA_Ddis       -P----------------------------------------------------------
QkgA_C2d_Ddis   -P----------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     -Q----------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      -P----------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      DLEKLNLILAYYINPLIDFGRYFSSVN---------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   -T----------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   -P----------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     -----------------------------------------------------------D
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   -----------------------------------------------------------P
GbpC_Ddis       -----NSGSH-V-----------------------------------------------I
Pats1_Ddis      NSNNNNNNNNLNKLSTLDN---TEIPLSMIYRWKMVKTGSLYDSFKIYCKDFRCKIIGFQ
QkgA_Ddis       -----------------------------------------------------------Q
QkgA_C2d_Ddis   -----------------------------------------------------------Q
Roco10_Ddis     -----------------------------------------------------------S
Roco11_Ddis     -----------------------------------------------------------Q
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      -----------------------------------------------------------N
Roco6_Ddis      -----NGDMKYL-----------------------------------------------D
Roco7_Ddis      -----------------------------------------------------------I
Roco8_Ddis      -----------N-----------------------------------------------E
Roco9_Ddis      -----------N-----------------------------------------------E
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   -----------------------------------------------------------E
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   -----------------------------------------------------------K
AqueK491_Aque   -------------RASSGSSSNPLDIM---------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   -----------------------------------------------------------E


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ----VLTH--GADP---------------ESYA---------VRK---------------
CG5483_Dmel     VVQSLLQH--GANP---------------NIVA-----------KPV-------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ----VLTH--GADP---------------ENYA---------VRK---------------
T27C10.5_Cele   LMTLLLDA--GADV---------------NLPL-----------AVL-------------
GbpC_Ddis       TSTN-------------------SVISNSSI---SSTGVIN-------------------
Pats1_Ddis      INSHVLVKF---KD---------------LLTK---------CSVP---TLD--------
QkgA_Ddis       LLEHLLHQQ---QP---------------ITSV---------GSKP---SFF--------
QkgA_C2d_Ddis   LLEHLLHQQ---QP---------------ITSV---------GSKP---SFF--------
Roco10_Ddis     DSQMPLSSS---PTMGYPRGNHNKKTSASA------------------------------
Roco11_Ddis     LQQQ-QQQQ---LQ---------------QQMK---------TPKL---LFF--------
Roco4_Ddis      ------SQQ---ND---------------NQAV---------PVIP---TFF--------
Roco5_Ddis      LYKQIVQVV---KDIVNESVNINKVISIS-------------------------------
Roco6_Ddis      LSKRMIYSL--------------ELMMIPEIENRFQGDFKS-------------------
Roco7_Ddis      ISQTIIQNI---N----------------VEHMKDQISQFSISIIN---TIFRSIEKFPP
Roco8_Ddis      LSKVVLEDL---NT---------------V-TL---------VKDE---LIQ--------
Roco9_Ddis      IPRAPLL-----------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      --DQLIRH--GHLL----------------------------------------------
LRRKb_Spur      -----VEL--GADV---------------NTG----------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   SISALFK-----------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   -----HNRYLSLCS---------------ESLR---------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   SDNHILEKK---LTY--------------FAST---------GTKP---DMR--------
AqueK491_Aque   ------------------------------TEM---------GRT---------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   -----VRI--GADV---------------NSSN---------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ---PLMQS--MALP---------------SPSA---------SIPPPSSQIR--------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   MAALLLSN--GANP---------------NATL-----------A---------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ----------------------------------------VSSQNRSPL-----------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------KSIKSPTI----------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      TVFQLFEMLYLDIHQVFSPDFCFELMKKIFFTKLICPILAN---LKSPPNMANGKFFTKT
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------PLHE--------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------TI----------------------------FAYNSK---------ESSFG----
QkgA_Ddis       ------VII---------------------------NLYNDD---------RQSYM----
QkgA_C2d_Ddis   ------VII---------------------------NLYNDD---------RQSYM----
Roco10_Ddis     ----------MNSTGVSSSSSGV-------------------------------------
Roco11_Ddis     ------IVM---------------------------SVG--V---------GKSYI----
Roco4_Ddis      ------VVV---------------------------NIG--V---------GPSFV----
Roco5_Ddis      --------GLFNSSD-------IVQNRKFLKEGILIEQFNNQ---------RISYYTFLF
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      YIEISKVVL---------------------------DIA---------FDRDQSRR----
Roco8_Ddis      ------LSQ---------------------------ELMNGDKGLKLQKKKKGAAG----
Roco9_Ddis      ------------------------------------ANNNNSSSNLISLGRSGITN----
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ---------N-TECF---------------------------------------------
QkgA_Ddis       ---------SEIVSF---------------------------------------------
QkgA_C2d_Ddis   ---------SEIVSF---------------------------------------------
Roco10_Ddis     ---KQAGAGEKVMQFLGKMSLSKERMSKLVSQSKEQYKTPSSPYQQSTSSSISSGSGTIS
Roco11_Ddis     ---------KNIKEE---------------------------------------------
Roco4_Ddis      ---------SEIKSA---------------------------------------------
Roco5_Ddis      SDIILFTEKIEDTSTI--------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      -GSVTTQEQI--------------------------------------------------
Roco8_Ddis      ---------TTISCF---------------------------------------------
Roco9_Ddis      ---------TSTANINGSNRNSV-------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------ASR---------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ----------IICSN---------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ---------------------------PDHS-----------------------------
QkgA_Ddis       ---------------------------AGSF-----------------------------
QkgA_C2d_Ddis   ---------------------------AGSF-----------------------------
Roco10_Ddis     GHTSPNSLNSVQVVPF-----------EGI------------------------------
Roco11_Ddis     ---------------------------AGTI-----------------------------
Roco4_Ddis      ---------------------------AGTT-----------------------------
Roco5_Ddis      --------NNNTMMAY-----------DGSF-----------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------M-----------------------------
Roco8_Ddis      ---------------------------SG-S-----------------------------
Roco9_Ddis      --------------GGNGSHDYTTNIWDI-YSPLIEGQRLKLDLDKDWRVVEFLSRDTST
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------D-----------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ---------------------------LGFT-----------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ---------------------------NGRL-----------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      IYPKRILIPNLIGDELLQSYVRKTQSKIPIFSWSNQNNKSMLFRICVYNQPFNNKFNSGG
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      -----------------HFIKGMIFRNTHSISMTAALNPT----LNNQVIPPSIPLPSKE
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      TLAYNNNSTIINNNSVIITNSSTIGTNTSGIS-------NSNHLIVGEIEPPS-PIKKRQ
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      EACNNFI----------NNIRSESSELEESFKRAKD-----------------------L
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ----QQIVDKKDTSSPLS-----------SLRSSKGIPSKSSKKDKQGFLSSSTSSIIPI
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      -----------IMEQK----------------------DQQFL-----------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     -------------EDH--------------------------------------------
LRRK2_Mmus      -----------VVEQK----------------------DEQFL-----------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      -----------LLQEYNRIGVSWDLWRTTTQSKLCEH-YPPTS-----------------
QkgA_Ddis       ------Q----FIEWR--------------------N--DESW-----------------
QkgA_C2d_Ddis   ------Q----FIEWR--------------------N--DESW-----------------
Roco10_Ddis     ----------------------------------------------FGIPLRVILRYPNE
Roco11_Ddis     ------P----ILEWFT-------------------N-YIRSW-----------------
Roco4_Ddis      ------Q----FIEWIV-------------------N--DQAS-----------------
Roco5_Ddis      ------Y----LLK-----------------------K----LERIV-------NIQVDD
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      NTCISFARADRQ------------IYLFSIFKEMLI------------------------
Roco8_Ddis      ------Q----LIDWLV-------------------KKLEVTR-----------------
Roco9_Ddis      QTTISTD----TVDVKL-------------------YNLFVNK-----------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------E----AV----E------------------N--YDKY-----------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------E----MIEILQE------------------G--GADV-----------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------E----AIEGS-----------------------GESH-----------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------NLCCKCFAKVA----------------MDDYL--KNV-M---
LRRK1_Hsap      ---------------------------N-----------------EFPVI--VRL-P---
CG5483_Dmel     ND-------PKCC--------------E-----------------EIYGL--SNV-P---
LRRK2_Mmus      ------------------NLCCKCFAKVA----------------VDDEL--KNT-M---
LRRK1_Mmus      ---------------------------N-----------------EFPVI--VRL-P---
T27C10.5_Cele   DT-------EYSV--------------E-----------------EGRCI--GSG-A---
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      -----------------VV-PKSVS-DNIVVTSAYYRSYGFPVLAWSHPT--QKS-S---
QkgA_Ddis       -----------------KE-VFKLS-SNL----------------LTYHV--KKN-E---
QkgA_C2d_Ddis   -----------------KE-VFKLS-SNL----------------LTYHV--KKN-E---
Roco10_Ddis     S--------GNQIPSILNS-I---------------------------------------
Roco11_Ddis     -----------------EE-VFKLT-SNQ----------------VTSHI--KRQ-L---
Roco4_Ddis      -----------------KE-VFKVS-TNL----------------LSHHK--KQI-E---
Roco5_Ddis      PELGFEYRKGFQIKTKESS-IFYMT-SSEK----------------EK------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      --------------------NFKIS-FNL----------------LNNNQ--NNN-Q---
Roco8_Ddis      -----------------KE-SIQIA-SAL----------------MHLNI---FI-E---
Roco9_Ddis      -----------------EE-QLQSS-T-----------------------------SSSP
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ----------------------------------------------FEQH--EPN-P---
LRRKb_Spur      ------------------------------------------------EG--YET-P---
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ---------------------------------------------EV-------------
AqueK486_Aque   -----------------------------------------------PHC--LED-T---
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   -------------------------------------------------IRSINYPI---
AqueK489_Aque   -----------------SE---------L----------------IIFRI----------
AqueK490_Aque   -------------------------------------------------D--IEE-A---
AqueK491_Aque   -----------------NA-IMRPS-L-D----------------RSANA--DLT-A---
AqueK492_Aque   -----------------------------------------------PHC--LED-A---
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ----------------------------------------------DPHG--ADS-A---
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ---------------------------T-----------------PFSKL--LLT-P---
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ---------------------------G-----------------EMGGL--AKN-P---


LRRK2_Hsap      -----------------------L------------------------------------
LRRK1_Hsap      -----------------------L------------------------------------
CG5483_Dmel     -----------------------I------------------------------------
LRRK2_Mmus      -----------------------L------------------------------------
LRRK1_Mmus      -----------------------L------------------------------------
T27C10.5_Cele   -----------------------L------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      -----------------------I------------------------------------
QkgA_Ddis       -----------------------L------------------------------------
QkgA_C2d_Ddis   -----------------------L------------------------------------
Roco10_Ddis     -----------------------FTILESSSALSTNRLFYGDYNTSTSNLASSISPISTA
Roco11_Ddis     -----------------------L------------------------------------
Roco4_Ddis      -----------------------L------------------------------------
Roco5_Ddis      ---------------STWFQVLSQA-----------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      -----------------------N------------------------------------
Roco8_Ddis      -----------------------V-----GT-----------------------------
Roco9_Ddis      STSLNNSSNNLNKEFQQIHQQMQQ-----NQ-----------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      -----------------------L------------------------------------
LRRKb_Spur      -----------------------M------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   -----------------------L------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   -----------------------F------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   -----------------------L------------------------------------
AqueK491_Aque   -----------------------L------------------------------------
AqueK492_Aque   -----------------------L------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   -----------------------I------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   -----------------------L------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   -----------------------L------------------------------------


LRRK2_Hsap      ---ERA------------------------------------------------------
LRRK1_Hsap      ---YAA------------------------------------------------------
CG5483_Dmel     ---AEA------------------------------------------------------
LRRK2_Mmus      ---ERA------------------------------------------------------
LRRK1_Mmus      ---YAA------------------------------------------------------
T27C10.5_Cele   ---VEA------------------------------------------------------
GbpC_Ddis       ---------------------------------------------NNINNNSNIN-----
Pats1_Ddis      ---TRATSPEDQNNGSSNYLLTPNSPNSSSSNLANNNNSNNNNINNNNNNNNNNNN--NN
QkgA_Ddis       ---ARA------------------------------------------------------
QkgA_C2d_Ddis   ---ARA------------------------------------------------------
Roco10_Ddis     ANTTI-------------------------------------PTISVPTSPNLSSSLSS-
Roco11_Ddis     ---TKA------------------------------------------------------
Roco4_Ddis      ---THA------------------------------------------------------
Roco5_Ddis      -SLKS-------------------------------------NQNQNQNQNNLTNSYSS-
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ---IN----------------------------------------QNNNNNNNQNC--NS
Roco8_Ddis      --IFN----------------------------------------SSNNNNNNNNG--GG
Roco9_Ddis      --LNS-------------------------------------SSNNNNNNNNNNNN--NN
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ---LFA------------------------------------------------------
LRRKb_Spur      ---CFA------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ---TAA------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ---LAA------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ---LQA------------------------------------------------------
AqueK491_Aque   ---VQA------------------------------------------------------
AqueK492_Aque   ---TAA------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ---YQA------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ---AEA------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ---AEA------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------NN---------NSN---NNNNNNN
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     -------------------------------------SSSSGSSGNSSPNIINQLQQQQQ
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      -------------------------------------TVAGGRNSTIGL---GGIDDFNN
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      NTSSPIISSRSGFYTLRNSSTNSSPTNPPLTARGNGSI---------SIGNNNNNNNNNN
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------NN---------NNN---NNNNNNN
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      NNNNNNNNNNNNN-----GGGSGSR-------STTIDNGQTSILNKNISNTPLIQSPTPN
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     PQPTTTTTTNTN------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      NNNGNNNGSNND------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      NNNNNNNNNNNNNNSGGGGG----------------------------------------
Roco8_Ddis      ------------------------------------G-----------------------
Roco9_Ddis      NNNNNNNNNNNNN-----KINKRQNEATIVFTNKVGGTSDNHINIISVYEQFK-------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      LPPSQHSLNLLMSPQTSSPRIHQS------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------TSPHQYLSQKSIKLEVENICNQYDQGIEVSLKKCNVHVV---
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------DGPDEFEDAKDIALFCKMIISGQ---------RPKVELTSQM
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     --------------SEILIEFFNRLPEPIISVEFYETLLNYYQT----------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      LKISDPKPLFAALAS----------------THFVNQLIFIPLTMNDKYMQMTLGMMSLN
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ----------------C-------------------------------------------
LRRK1_Hsap      ----------------I-------------------------------------------
CG5483_Dmel     ----------------C-------------------------------------------
LRRK2_Mmus      ----------------C-------------------------------------------
LRRK1_Mmus      ----------------I-------------------------------------------
T27C10.5_Cele   ----------------V-------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      -------ISSSSIPQVCQEDIDFLRGILDIKSSSMLNVFDTGSGGSYSSTMIGCQIEFLN
QkgA_Ddis       ----------------C-------------------------------------------
QkgA_C2d_Ddis   ----------------C-------------------------------------------
Roco10_Ddis     ETLLHLMI--RKMNNPNKS-----------------------------------------
Roco11_Ddis     ----------------C-------------------------------------------
Roco4_Ddis      ----------------C-------------------------------------------
Roco5_Ddis      KSITHLTLSQNSINDPCAV-----------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      --------------------------------------------------MNSSNIIFLS
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ----------------C-------------------------------------------
LRRKb_Spur      ----------------C-------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ----------------V-------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ----------------V-------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ----------------V-------------------------------------------
AqueK491_Aque   ----------------A-------------------------------------------
AqueK492_Aque   ----------------V-------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ----------------V-------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ----------------C-------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ----------------A-------------------------------------------


LRRK2_Hsap      ----------------------------------------------------D-------
LRRK1_Hsap      ----------------------------------------------------K-------
CG5483_Dmel     ----------------------------------------------------K-------
LRRK2_Mmus      ----------------------------------------------------D-------
LRRK1_Mmus      ----------------------------------------------------K-------
T27C10.5_Cele   ----------------------------------------------------R-------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      LPPPNKVRERFNRLL------HLHLGNPDSEWSETIRFFWLDPLKPILSAAIN-------
QkgA_Ddis       ----------------------------------------------------T-------
QkgA_C2d_Ddis   ----------------------------------------------------T-------
Roco10_Ddis     ----------------------------------------------------ILCRLMKY
Roco11_Ddis     ----------------------------------------------------T-------
Roco4_Ddis      ----------------------------------------------------T-------
Roco5_Ddis      ----------------------------------------------------ALGDMLRY
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      IPTREQVEACW---FDLYQSITSFDGSMDA-WKSIEESKWVDSVKLLLEGCV--------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ----------------------------------------------------Q-------
LRRKb_Spur      ----------------------------------------------------E-------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ----------------------------------------------------E-------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ----------------------------------------------------R-------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ----------------------------------------------------L-------
AqueK491_Aque   ----------------------------------------------------M-------
AqueK492_Aque   ----------------------------------------------------E-------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ----------------------------------------------------S-------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ----------------------------------------------------V-------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ----------------------------------------------------I-------


LRRK2_Hsap      -------------------------------------QNN--------------------
LRRK1_Hsap      -------------------------------------SGN--------------------
CG5483_Dmel     -------------------------------------QRS--------------------
LRRK2_Mmus      -------------------------------------QNN--------------------
LRRK1_Mmus      -------------------------------------AGN--------------------
T27C10.5_Cele   -------------------------------------SDG--------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      -------------------------------------IAM--------------------
QkgA_Ddis       -------------------------------------LGD--------------------
QkgA_C2d_Ddis   -------------------------------------LGD--------------------
Roco10_Ddis     LKD-IMVYTNFNDVTLELLVERFHKFILRPTIGTIAQSKE--------------------
Roco11_Ddis     -------------------------------------TGN--------------------
Roco4_Ddis      -------------------------------------VGD--------------------
Roco5_Ddis      NHSLIQMDLSENTIA---------------------DKGL--------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ---------------------------------------GLNNSSNLLINPWVSSYQNSN
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      -------------------------------------GGH--------------------
LRRKb_Spur      -------------------------------------NNN--------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   -------------------------------------VGN--------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   -------------------------------------DKR--------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   -------------------------------------SGA--------------------
AqueK491_Aque   -------------------------------------TND--------------------
AqueK492_Aque   -------------------------------------VGN--------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   -------------------------------------ISS--------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   -------------------------------------FNS--------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   -------------------------------------NNN--------------------


LRRK2_Hsap      SIMVECLLL-LGA-----------------------D----AN--Q----AKEGSSLICQ
LRRK1_Hsap      EDIAIFLLR-HGA-----------------------Y----FC--S----Y---------
CG5483_Dmel     LAMLDLLLK-HGA-----------------------R----DD--N----G---------
LRRK2_Mmus      SIMVECLLL-LGA-----------------------D----AN--Q----VKGATSLIYQ
LRRK1_Mmus      EDIAIFLLR-HGA-----------------------Y----FC--S----Y---------
T27C10.5_Cele   LHIVHFLLD-RGA-----------------------L----DT--D----N---------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      HVDQGRSVL---------------------------------------------------
QkgA_Ddis       INLLDEIIL-SGC-----------------------S----KS--Q----L---------
QkgA_C2d_Ddis   INLLDEIIL-SGC-----------------------S----KS--Q----L---------
Roco10_Ddis     ISESHL------------------------------------------------------
Roco11_Ddis     INLLDEILL-SGI-----------------------S----KE--Q----I---------
Roco4_Ddis      VNYLDQIIL-SGV-----------------------S----TD--Q----L---------
Roco5_Ddis      ISLIDGILS-HPS-----------------ITVVILT----QN--Q----I---------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ISNSDQVQS-TRV------------------VQSFSK----KW-----------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      --KVSNLLD-EG------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      YSIVADLIE-RGL-----------------------V----SI--D----E---------
LRRKb_Spur      VDMVKQLLK-QGI-----------------------S----DL-------H---------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   --LARPLINDHVL-----------------------RFDTAQE--NASFIT---------
AqueK486_Aque   QLNVGKLII-KGA-----------------------T----NI--Q--------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   LEVLEMVFS-NQETRPLPDRILSRPYVLGKKTENVPG----EN-------M---------
AqueK489_Aque   --ILAPLLQ-NGK-----------------------I----NI--S--------------
AqueK490_Aque   DDNIAPLIL-AGA-----------------------R----RL--D----C---------
AqueK491_Aque   VKMVRFLLQ-HGA-----------------------T----DA--R----L---------
AqueK492_Aque   HFNVGRLVV-KGA-----------------------K----NI--Q--------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   TDVVKVVLE-SRL-----------------------T----NRTLL----K---------
AqueK495_Aque   KNILDELQS-MSC-----------------------T----DR--G----V---------
AqueK496_Aque   QDIVEILIN-HGA-----------------------K----DL--N----G---------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   PLMIRTLVS-YGA-----------------------E----DR--R----H---------


LRRK2_Hsap      VCEKESSPKLVELLLNSGSREQDVRKALT-I--------------S---I----------
LRRK1_Hsap      -------------------------I-L-----------------L--------------
CG5483_Dmel     -------------------------TAIG-M--------------A---I----------
LRRK2_Mmus      VCEKESSPKLVELLLNGGCREQDVRKALT-V--------------S---I----------
LRRK1_Mmus      -------------------------I-L-----------------L--------------
T27C10.5_Cele   -------------------------KALR-L--------------A---A----------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ----------------------------I-Q--------------N---S-------SSG
QkgA_Ddis       ----------------------------K-E--------------A---Q----------
QkgA_C2d_Ddis   ----------------------------K-E--------------A---Q----------
Roco10_Ddis     ----------------------------------KTIKDIV--TMF--------------
Roco11_Ddis     ----------------------------K-E--------------T---Q----------
Roco4_Ddis      ----------------------------K-E--------------A---H----------
Roco5_Ddis      ----------------------------T-DTGAKHI---SKLLKF--------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      -------------------------------------------------SSVLLKPPIDS
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      -------------------------A-AV-Y--------------M--------------
LRRKb_Spur      -------------------------TPLS-R--------------C---L----------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   -------------------------ETME-W--------------A---L----------
AqueK486_Aque   -------------------------QALD-D--------------S---K----------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   -------------------------NAVG-V--------------ACECC----------
AqueK489_Aque   -------------------------TAIN-V--------------A---M----------
AqueK490_Aque   --------------------------ALY-L--------------A---I----------
AqueK491_Aque   -------------------------KALT-R--------------A---M----------
AqueK492_Aque   -------------------------QALE-D--------------S---K----------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   -------------------------DAFV-L--------------A---K----------
AqueK495_Aque   -------------------------DKLLDI-----------------------------
AqueK496_Aque   -------------------------YGCQ-I--------------A---Y----------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   -------------------------DALN-Y--------------A---L----------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      PDIELQL---SSLAQILLDPYYRTMDGFKV-LIEKEWLSYGYPFSKRCHHKTSDD-----
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ----------------------------TSDELRPTYLGK-SPKKRSW------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      PLHTLDLASISSLTMVLSDPFYRTLDGFLI-LIEKEWIQYGFPFNNINYHKEQNNLNNNN
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------GK----------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------TC----------------------------
LRRK2_Mmus      ------------------------------QK----------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------QG----------------------------
GbpC_Ddis       -------SNTGTT-----------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     -----------------------------------------------IQQADILFQSPEE
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      -----------------------------------------------NQTLNALFLE-DN
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      -------------------------------------------VMSST------------
Roco9_Ddis      GNKENSSSSSSSSSSTSTTPSITKKSSGSISKGSSGIASLINDLDKYD------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------KL----------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------TT----------------------------
AqueK486_Aque   ------------------------------RL----------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------LN----------------------------
AqueK489_Aque   ------------------------------TS----------------------------
AqueK490_Aque   ------------------------------QQERFKAIAML-------------------
AqueK491_Aque   ------------------------------RM----------------------------
AqueK492_Aque   ------------------------------RL----------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------RK----------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------LI----------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------SQ----------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ---------------------------------------------GFSPIFMQF----IF
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     RMNTDDAQILYIEE-VLTSTQKSQHQSS--------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      NI-------------------------TQ-------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      -----------LSTTIPSSISLQQLSNQSQSNSNSSSSSSILNLSFTAPISISSTTATMS
Roco9_Ddis      -----------SNFVLPDT-IHTESQKKKTYLFQDQYESSILVNRSFSPIFVQF----LD
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   -----------------------MVCKAT-------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      LVWQIWKEFPTHFQFNEYYLLTLLDNVYNSR--------------------FGTFLCNNY
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     -------------------------------VGNLWLF----------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------SMGAEIIDQWVSCHSTVLSRITLPSIPPEY
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ---------------------------------------------------------SSL
Roco9_Ddis      AVWQLQRQFPFHFEFNESLLLLLVKESFSGR--------------------FGNFLYSEA
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ---------------------------G-------DSQI-------------------IS
LRRK1_Hsap      -----------------------------DSPDP----S-------------------KH
CG5483_Dmel     ---------------------------G-------DEAI-------------------LS
LRRK2_Mmus      ---------------------------G-------DSQV-------------------IS
LRRK1_Mmus      -----------------------------DSPEP----S-------------------KH
T27C10.5_Cele   ---------------------------K-------NEKL-------------------IR
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      KERMENNVYSSTKSFWSFQQQNQS---R-------FTNL------------------FYR
QkgA_Ddis       ----------------------GA---G-------YTIV-------------------FN
QkgA_C2d_Ddis   ----------------------GA---G-------YTIV-------------------FN
Roco10_Ddis     ----------HKQIVWRPKVNIDHGEPD-------LAIL-------------------FS
Roco11_Ddis     ----------------------TI---G-------HGII-------------------LK
Roco4_Ddis      ----------------------KA---G-------HAIV-------------------FD
Roco5_Ddis      SDRIKLKAISVTNRLDKKK-----------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      SLSTTAATTTTTTTSSSLLNNSSS---G-------SGFLVPTLPASVLNSSSNSNNQLYS
Roco9_Ddis      LRDSERKFLKRS----------------------------PSIWTFINQNKSTFINLLYK
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      -----------------------------MGAD-----I-------------------LP
LRRKb_Spur      ---------------------------K-------QHHI-------------------IG
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ---------------------------G-------SANI-------------------LT
AqueK486_Aque   ---------------------------Q-------KHEA-------------------RA
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ---------------------------G-------DPSV-------------------FD
AqueK489_Aque   ---------------------------G-------KLSM-------------------AG
AqueK490_Aque   ----------------------IT---G-------DCQA-------------------IR
AqueK491_Aque   ---------------------------P-------YHDV-------------------VG
AqueK492_Aque   ---------------------------Q-------KHEA-------------------RA
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ---------------------------N-------LDPI-------------------IG
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ---------------------------H-------QPSL-------------------VN
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ---------------------------DMTQPNGLKAEV-------------------IP


LRRK2_Hsap      LLL--------RRLAL------------------D-------------------------
LRRK1_Hsap      L---------------------------------------L-------RKYFIEASPLPS
CG5483_Dmel     RLL--------ARRVHPDSD------------------YKINKKGLPT-PVEVN-VFLPS
LRRK2_Mmus      LLL--------RKLAL------------------D-------------------------
LRRK1_Mmus      L---------------------------------------L-------RKYFIEASALPS
T27C10.5_Cele   VFL--------VRLVFADPE------------------YKINKKNIDVGQIQVGQSLLPS
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ----------PS----PS---SSSSSSSSSSS-LSNGY----------------------
QkgA_Ddis       ---------------------SYTSYSSGSSL-VVSGT----------------------
QkgA_C2d_Ddis   ---------------------SYTSYSSGSSL-VVSGT----------------------
Roco10_Ddis     SILKIV----LY----TP---PQSSSSSSSSS-ISNSS-------------SAS----SS
Roco11_Ddis     ---------------------SLIVNN-LDSI-VVSGS----------------------
Roco4_Ddis      ---------------------SLLTHNS-NSL-VVTGT----------------------
Roco5_Ddis      ---KQLQVNQKS----TT---PSTSTSTTSST-IINNN----------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ----------SS----PL----SLSTSS-----I--------------------------
Roco9_Ddis      ----------HS----AN----SSSSSSSTNK-L--------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      L---------------------------------------L-------KKWVVPDDSSTN
LRRKb_Spur      LLL--------YQ-------------M----G-CD-------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   HL---------RDLGYEISE------------------DLIRKYDETVGAYLLGE-YPPK
AqueK486_Aque   MLL--------LVIAA------------------Q-------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   AML--------SH-------------Q----V----------------------------
AqueK489_Aque   RIL--------QH---------------------------------------------V-
AqueK490_Aque   SLI--------SE-PPPVSSSTNWYMSEVHKL-LSQGT----------------------
AqueK491_Aque   LLL--------CY-------------N-GSVT-IDSSNMEL-------RKRLGK----AS
AqueK492_Aque   MLL--------LVIAA------------------Q-------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   LLL--------KA-------------L----G-LD-------------------------
AqueK495_Aque   -------------------------------AE-------------------LAYNLDST
AqueK496_Aque   LIL--------SY-------------Q----CK-------------------LCEQIEDK
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   LLF--------GS-------------L----VKCDEN---A-------TKTLAQSRKEPR


LRRK2_Hsap      ---------------------------V-ANNSICLGG----F-----------------
LRRK1_Hsap      -----------------------S-YPGKTALRVKWSH----L-----------------
CG5483_Dmel     TS----------------NISYSAMFPN-NPTIIDWHSMGSSV-----------------
LRRK2_Mmus      ---------------------------L-ANNSICLGG----F-----------------
LRRK1_Mmus      -----------------------S-YPGKIALRVKWSH----L-----------------
T27C10.5_Cele   -----------------------SLCPS-KAAQLNWNS----A-----------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------N---------------------SSVQHLKCLRVF--
QkgA_Ddis       ------------------------M---------------------A-------------
QkgA_C2d_Ddis   ------------------------M---------------------A-------------
Roco10_Ddis     -----------------------SSST-PSISSTSLSS-----SLKV-------------
Roco11_Ddis     ------------------------M---------------------S-------------
Roco4_Ddis      ------------------------M---------------------A-------------
Roco5_Ddis      ------------------------KGL-LDLGSCDYSE----ISLQL-------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------P---------------------A-------------
Roco9_Ddis      ------------------------P---------------------SPISPRQSFI-FKQ
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      -----------------------T-DNDKKELIANWHH----K-----------------
LRRKb_Spur      ---------------------------R-QAGSLTWSS----L-----------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   TLSKFSIIKRPEFSERGEESELDED-DE-PQTIIDT---RPS------------------
AqueK486_Aque   ---------------------------T-NDR----------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   -----------------------S-HH-PSSGIVDWHD----L-----------------
AqueK490_Aque   ------------------------V---------------------K-------------
AqueK491_Aque   -----------------------P-SS-PLLLAVNWAS----K-----------------
AqueK492_Aque   ---------------------------T-NDR----------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ---------------------------K-DKSILNIGG----M-----------------
AqueK495_Aque   ------------------------------------------R-----------------
AqueK496_Aque   -----------------------P-HPHP-LYTLDWKE----K-----------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   -----------------------S-HRHK-MAVVEWNG----L-----------------


LRRK2_Hsap      -----------------------------------------CIGKVE-------------
LRRK1_Hsap      -----------------------------------------RLPWVD-------------
CG5483_Dmel     -----------------------------------------QLSVVR-------------
LRRK2_Mmus      -----------------------------------------GIGKID-------------
LRRK1_Mmus      -----------------------------------------KLPWVD-------------
T27C10.5_Cele   -----------------------------------------NLEQLQ-------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      --------------QDTMWNEYFFRYCFKSSLAIEQFEDRIKLSLLDIEM--TV------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     --LPN-----------------FTVYCSSDTKTVITFSFQSPSTCKLIYAYINS------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      --LN--------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ---------------VLDKKN-------------------IKTQII--------------
Roco8_Ddis      --FDNRIVEDC-------------------------------------------------
Roco9_Ddis      EDFNEMIKPSCDNDQIILWSSFFTEFI-------------------------NSRESQQI
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      -----------------------------------------QLNTFD-------------
LRRKb_Spur      -----------------------------------------GLARLN-------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   -----------------------------------------ELSYID-------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   -----------------------------------------KLPYIT-------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   -----------------------------------------DLQVIK-------------
AqueK495_Aque   -----------------------------------------SMETVQ-------------
AqueK496_Aque   -----------------------------------------HLRIVK-------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   -----------------------------------------DMTEFK-------------


LRRK2_Hsap      ----------------------------PSWLGPLF------------------------
LRRK1_Hsap      ----------------------------LDWLIDI-------------------------
CG5483_Dmel     ----------------------------VPWMVSGVLLL---------------------
LRRK2_Mmus      ----------------------------PSWLGPLF------------------------
LRRK1_Mmus      ----------------------------LDWLLDI-------------------------
T27C10.5_Cele   ----------------------------SDWFVAAALHV---------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      -------------NSAIT--STANALLP-------FL-----------------------
QkgA_Ddis       ------------------------LLCA-------IV-----------------------
QkgA_C2d_Ddis   ------------------------LLCA-------IV-----------------------
Roco10_Ddis     ---------------VTK---SISQLNR--------------------------------
Roco11_Ddis     ------------------------LLGA-------VI-----------------------
Roco4_Ddis      ------------------------LLGA-------IV-----------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ---------------------------NLHIFL--D------------------------
Roco8_Ddis      ---------GNVFYE---FLTKPEAIINHV-----AM-----------------------
Roco9_Ddis      SKKLIGKVKCDLISQKLTFLSIDRNLLS-------YF-----------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ----------------------------PSWLQGFQDS----------------------
LRRKb_Spur      ----------------------------PEWLYKVFLDEE--------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ----------------------------PHWLQGHG------------------------
AqueK490_Aque   ------------------------MYCP-------IA-----------------------
AqueK491_Aque   ----------------------------PLWIDMVLIE----------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ----------------------------PSWIYPSLGIRATGRSRGHRRENSLDYVLSGL
AqueK495_Aque   ----------------------------ENW-----------------------------
AqueK496_Aque   ----------------------------GDWFFSDLYS----------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ----------------------------PEWFYDSLNT----------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      --------PPDPDSPNVSGLNETDSGNSSFIASKILMKAETRQQRVKLQEHMAKHDITKM
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   MRRSSTGTSPDK-----DSLDKRDAVDGGGVAN---------------K-----------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      LKWTISTASLPLPLSPGGPRTPGGPRTQHPVPVRRVVSEMQQPPPSASDINPPRWDAESA
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ----------------------------------------EGVAPAAGYGSTPERPSEAE
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      KLQG---------FLRRDDDEILKTHAYYINHSDSDQGGSTATLMPSR------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   DAYKLAKSWDANKF-----------EVYYT-----------SSSPPSSTPSRYVKERQRR
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   LMASRPPSLPTVVCSPVPVVKEPPLSPKQADALVSSDYEQFQGSFPGEGVAKEGGTGEDE
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      -----------------------------------------------------FTSTPRS
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   VDGGGGSGLDSRRGSGLDSRRGSGQDSRRGSVASRDDESCRRVPQRRHTFISKTTTG---
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      HLRPLTIPIGATAATSDTDDEMGDYWRDQPSLGRLPPSEARSS-----------QGLNGR
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   -------------------ASYLPFNTLDL-LQQQGPANLPHSSGACNKMAAEGDTF---
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      RSPIPDGRKSPLLVETLKKNSARSASVSSFFEP-VDETDLAETARRKRFSSGSELPPKAS
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   -------------------------------SPVYVRKTVF-------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ----------------NPKL----Q-S---------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ----------------NPRL----------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      RLRKKSLSSAQLPILMDDPRWVMHMEQNLGSSIELSESESSLAILPSRPELKKRESIIST
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ----------------VSIM----VK----------------------------------
AqueK491_Aque   ----------------APSY----LN----------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   -----------------------------------------------KNQLSKRQSTPPT
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ----------------LDLDVSLFLNC---------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ----------------CPLF----V-S---------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------HPR-LNEV----------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   --------R-TTRL----------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ----VSTADSSSMYLADESVSVQNLDVSSQDERRLSGNPPGKMFQFQFGGGISSEYA-VS
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   -------------L----------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   LLINSSQSRSSSPFQSSDEVGVVALG-----------------------GTSKTQYNTLL
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------QPMTFNKL----------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------QSL-TENL----------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      DSSTADDFSD-----AGMVSSSIPDVVSQIGVQRPQRMYRNTPQRQKRRSLTAPSNMHDL
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ---------------------------------------------NY-------------
AqueK491_Aque   ---------------------------------------------KP-------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   DSITAMPKDKRSELLSSLIS--------------------STD-----EGADQPDGAAAL
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      --------PDKTSNLRKQTNIASTLARMVIRYQMKSAVEEGTASGSDGNFSEDVLSKFDE
LRRK1_Hsap      --------S---------------------------------------------------
CG5483_Dmel     -------AL---------------------------------------------------
LRRK2_Mmus      --------PDKSSNLRKQTNTGSVLARKVLRYQMRNTLQEGVASGSDGKFSEDALAKFGE
LRRK1_Mmus      --------S---------------------------------------------------
T27C10.5_Cele   -------SL---------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      -------TH---------------------------------------------------
LRRKb_Spur      --PEGP--D---------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   -------QL---------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   -------IG---------------------------------------------------
AqueK489_Aque   --------V---------------------------------------------------
AqueK490_Aque   -----DATK---------------------------------------------------
AqueK491_Aque   -----KAES---------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   SPPGGPSGS---------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   -------ES---------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   -------CL---------------------------------------------------


LRRK2_Hsap      WTFIPDSSMDSVFAQSDDLDSEGSEGSFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSN
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      WTFIPDSSMDSVFGQSDDLDSEGSESSFLVKRKSNSISVGEVYRDLALQRCSPNAQRHSN
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   --------------------------------------------DLVLKLFDARIQR--N
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   --------------------------------------------DLVLKLFGVPAQK--N
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      SLGPIFDHEDLLKRKRKILSSDDSLRSSKLQSHMRHSDS-------ISSLASER---EYI
LRRK1_Hsap      ---------------------------------------------------------CQI
CG5483_Dmel     ---------------------------------------------------------TAI
LRRK2_Mmus      SLGPVFDHEDLLRRKRKILSSDESLRSSRLPSHMRQSDS-------SSSLASER---EHI
LRRK1_Mmus      ---------------------------------------------------------CQI
T27C10.5_Cele   ---------------------------------------------------------AAI
GbpC_Ddis       -----------------------------------------------------------T
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ---------------------------------------------------------IIP
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      -----------------------------------------------------------I
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ---------------------------------------------------------RRL
Roco9_Ddis      ---------------------------------------------------------STL
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ---------------------------------------------------------QVL
LRRKb_Spur      ---------------------------------------------------------ICI
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ---------------------------------------------------------SKT
AqueK486_Aque   ASHPMANDDDFSEVQKAVISGRVSTM-VPIEIARRHQNPIVREDLLLRTNVNQEEGSVYW
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ---------------------------------------------------------KQL
AqueK489_Aque   ---------------------------------------------------------NSF
AqueK490_Aque   -------------------------------------------ELLLCTDLD-----MRR
AqueK491_Aque   ---------------------------------------------------------YAL
AqueK492_Aque   TTHPLANDDDFSEVQKAVISGRVSTV-VPIEIARRHQSSVVREELLLRTDVNQEEGSVYW
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ---------------------------------------------------------FYI
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ---------------------------------------------------------ASI
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ---------------------------------------------------------KFI


LRRK2_Hsap      TSLDLSANELRDIDALSQ-KC-------CI--SV--H-LEHLEKLELHQNALTSFPQQLC
LRRK1_Hsap      TELDLSANCLATL------PS-------V--IPW--G-LINLRKLNLSDNHLGELPGVQS
CG5483_Dmel     TRIDFSHNVLTSI------PQ-------E--L-F--H-LVSLRYLNVAQNKITDLPAPIG
LRRK2_Mmus      TSLDLSANELKDIDALSQ-KC-------CL--SS--H-LEHLTKLELHQNSLTSFPQQLC
LRRK1_Mmus      TELDLSANCLPSL------PS-------I--IPW--G-LINLKKLNLSNNQLGELPCVQS
T27C10.5_Cele   TRVDLSDNRLNTF------PS-------I--L-F--Q-MPSLRSLNLADNSIRKIEIPTY
GbpC_Ddis       TTISLPNN--TEI------KTALVSTGSQ--N-ASDT-AQIDIEFHLSYTQLVTLPPSIF
Pats1_Ddis      ETLDLSNLRLYYL------PS-------ESTL-Y--H-LVGLRELNLSKNNLNSISCSLS
QkgA_Ddis       ---------------------------------------ENGTFLLLSKSNI--------
QkgA_C2d_Ddis   ---------------------------------------ENGTFLLLSKSNI--------
Roco10_Ddis     QKLDMFSLELESL------PN-------E--I-K--Q-LKDLQELNLNRNKFKLLPGDLA
Roco11_Ddis     DND---------------------------------N-DKKGSSLILSKLNL--------
Roco4_Ddis      EN----------------------------------G-DRKGKRLSLSRSNL--------
Roco5_Ddis      --------KLNML------SL-------D--S-R--R-ISDLKELYLDHNCISSIPVSIL
Roco6_Ddis      SILNLNDNLLGEI------PE-------S--L-K--Q-LTQLISLSIRGNHILEIPLWFP
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      DDLCLTHKCISII------PT-------T--I-I--------------------------
Roco9_Ddis      TKLNLSRNYFNTF------PI-------E--I-I--L-LSNLTHLWLQDNRIKSIPSSLL
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      STINLSQNSLFSV------PE-------G--LLW--G-LQNLRRLNLSQNSLQLLPSPKS
LRRKb_Spur      KFVDLSANNVSDLTPLSRAPH-------R--LLQ--E-FRFLEKLDLSDNGLTEFPKELT
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   HLLQLSDISLTLI------PS-------S--F-F--Q-D---------------------
AqueK486_Aque   ----------HGLRLLEL-DL-------SW--IR--K-IHWVKRLRLARNGFRAIPNEIG
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   VNLSLADLGVKEV------PL-------E--L----F-HENLISLSLSGNKLEELPPTKD
AqueK489_Aque   TYVGLSSNLLKCI------PE-------Q--I-L--R-FNNLQ-----------------
AqueK490_Aque   KTVDWSRLKLTLL------HH-------SW-V-Y--SIAPWVVNLKLGNNNLRKLPLEFV
AqueK491_Aque   SQLNISDNKLNEL------PV-------A--I-F--Q-LKNLLRLELNRNNISSLPVSDD
AqueK492_Aque   ----------HGLRLLVL-DL-------SW--IR--R-IHWVKRLRLARNGFQAIPNEIG
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   KSIDASANQLESLDTLVI--D-------P--IPA--K-LKQLLYVDMKQNKLTGLPEALF
AqueK495_Aque   ----------------------------------------------------SATPRS--
AqueK496_Aque   HIVHLQKNCLQTL------PI-------E--L-F--Q-LPNVAEINVAENSLTSLPDIDS
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   NRLNISKNKLTFV------PI-------E--F-F--R-LQNLTTLNLSHNCLGELPDVVP


LRRK2_Hsap      -----------ETL---KSL----------------------------------------
LRRK1_Hsap      S--------DEIIC---SRL----------------------------------------
CG5483_Dmel     Q---------TYGC---PVL----------------------------------------
LRRK2_Mmus      -----------ETL---KCL----------------------------------------
LRRK1_Mmus      S--------DEIIC---SRL----------------------------------------
T27C10.5_Cele   Y----------ISS---TSL----------------------------------------
GbpC_Ddis       -----------S------------------------------------------------
Pats1_Ddis      -----------SLV----KLEKLSFEENSIT-NLPI------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     -----------RLT----SLRTICIEENNLT-EISS------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      -----------K------------------------------------------------
Roco6_Ddis      -----------E------------------------------------------------
Roco7_Ddis      -----------------------NYSVCRIV-TVPMNITFQALANRIHTDSEFSDIQLNK
Roco8_Ddis      -----------NTS---KFLRIIDLSFNQLS-ESNQ----------------------LE
Roco9_Ddis      -----------KLIGSKLKLQEFDLSHNLLE-SLHK------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      H--------RNLSD---CRL----------------------------------------
LRRKb_Spur      -----------DYM---PEL----------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ----------LLPL---SSI----------------------------------------
AqueK486_Aque   -----------GYL---KQV----------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   -----------WKC---INL----------------------------------------
AqueK489_Aque   ---------------------KV-------------------------------------
AqueK490_Aque   -----------HAT----QLRRL-------------------------------------
AqueK491_Aque   -----------WEC---DSLEHI-------------------------------------
AqueK492_Aque   -----------DYL---KQV----------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   -----------EEL---SQV----------------------------------------
AqueK495_Aque   --ALLVLSKFARQCN--KRYEQLHLSYQSISNLLPQ------------------------
AqueK496_Aque   DSCTVSTGTNAWKC---SQLTVLILSSNNLS-CLPT------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   MATD--STTPTWPC---GSL----------------------------------------


LRRK2_Hsap      --------------------------------------------------THLDLHSNKF
LRRK1_Hsap      --------------------------------------------------LEIDISSNKL
CG5483_Dmel     --------------------------------------------------DELFLQDNQL
LRRK2_Mmus      --------------------------------------------------IHLDLHSNKF
LRRK1_Mmus      --------------------------------------------------LEIDISSNKL
T27C10.5_Cele   --------------------------------------------------EILNLRNNQL
GbpC_Ddis       ----------LI------------------------------------WIQKLVLTHHNI
Pats1_Ddis      ETVVLLAEK-LT------------------------------------SLTELNLSSNQL
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     EMADFLGTR-LS------------------------------------NLENVTLSSNRL
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      --------E-LK------------------------------------NLQILDLSNNQL
Roco6_Ddis      --------E-FK------------------------------------LLRKLDVSHNAI
Roco7_Ddis      EEYEMVIRYPEE------------------------------------SITVLNDEGNQE
Roco8_Ddis      SI-----AT-LY------------------------------------NLESCNLSHNQL
Roco9_Ddis      SI-----YT-LS------------------------------------TLTKLVLDNNKL
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      --------------------------------------------------RSLSLYQNEL
LRRKb_Spur      --------------------------------------------------QELNLRSNGI
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   --------------------------------------------------THVDFSRNLL
AqueK486_Aque   --------------------------------------------------VKLDLQHNEL
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   --------------------------------------------------TFLSLANNLF
AqueK489_Aque   -----------------------------------------------------QMHHNRI
AqueK490_Aque   -----------------------------------------------------DLSCNLL
AqueK491_Aque   -----------------------------------------------------DMSHNQL
AqueK492_Aque   --------------------------------------------------VKLDFQRNEL
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   --------------------------------------------------KNLQLGQNCF
AqueK495_Aque   N------------------------------------------IS-DTLYTHINLSHNNM
AqueK496_Aque   CL-----WF-LPSLEILKASMNKLESLVPLPEAFNSLIDRDESIVLAPNLREIDLSRNSL
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   --------------------------------------------------NKLDISHNQL


LRRK2_Hsap      T-SFPS-------------------------------Y-LLK-MSCIANLDVSRNDIGPS
LRRK1_Hsap      S-HLPP-------------------------------G-FLH-LSKLQKLTASKNCLEKL
CG5483_Dmel     T-TLPA-------------------------------A-IFH-LPALSILDVSNNKLQQL
LRRK2_Mmus      T-SFPS-------------------------------F-VLK-MPRITNLDASRNDIGPT
LRRK1_Mmus      S-HLPP-------------------------------G-FLH-LSKLQKLTASKNYLERL
T27C10.5_Cele   E-CIAI-------------------------------QFLSS-LPQLQQLDVSKNELSQL
GbpC_Ddis       K-TLSE-------------------------------D-IGK-LQQLQVLVLENNRLINL
Pats1_Ddis      I-DLPI-------------------------------E-FSMFSKSLKKLHLKNNRFSAI
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     V-VLPP-------------------------------L-Y-T-WLKLKTLNISNNYLTKL
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      S-SLPS-------------------------------E-ISE-MKELKLLNVSHNNLSSL
Roco6_Ddis      S-SVPN-------------------------------T-FNK-FSILEDLNLSNNYISYI
Roco7_Ddis      VICEPELPLWMFDIDTESIIIFRPIKRRSPSSSFNIFL-KF-IFPSNSSFNSSSSSLPST
Roco8_Ddis      S-TLPS-------------------------------S-FSR-LELLTKLILSHNCFQVI
Roco9_Ddis      I-IIPE-------------------------------S-ISK-MKQLKCLSVQNNRLSSF
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      L-SVPA-------------------------------E-LFM-LKELEFLSLASNAMEEL
LRRKb_Spur      T-ELPT-------------------------------H-LLS-LSKLTLLDLSHNQIKDL
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   C-EIPV-------------------------------E-LCQ-LPSLTYLNLSHNFLSSL
AqueK486_Aque   V-TVPH-------------------------------C-LFE-LPNLN------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   S-VVPP-------------------------------G-LFQ-LPKLTNLNLSSNKLVKI
AqueK489_Aque   T-DIPH-------------------------------E-LFS-LPRIKDIDLSFNLISAL
AqueK490_Aque   E-KIEI-------------------------------G-LFS-LPNLEGLNLSQNKLRDL
AqueK491_Aque   T-SLPP-------------------------------L-LFT-LPELKELCANNNAIRDV
AqueK492_Aque   V-TVPC-------------------------------C-LFE-LPSLN------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   I-SLPL-------------------------------E-IGL-CSNLVELDLAGNSIAEF
AqueK495_Aque   K-SVPE-------------------------------E-LFQ-LQRLQYLDLSHNAIEKL
AqueK496_Aque   K-EIDN-------------------------------F-VFG-LSELSKLNLSQNELQSL
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   K-ELPI-------------------------------Y-LFE-LPQLSILDASHNQLTAL


LRRK2_Hsap      -----------------VVL----------DPTVK-CPTLKQFNLSYNQLS-----FVPE
LRRK1_Hsap      -----------------FEEE--------NATNWIGLRKLQELDISDNKLT-----ELPA
CG5483_Dmel     -----------------PFDL------------WR-APKLRELNVAFNLLR-----DLPV
LRRK2_Mmus      -----------------VVL----------DPAMK-CPSLKQLNLSYNQLS-----SIPE
LRRK1_Mmus      -----------------FEEE--------NATNWIGLRKLQELDLADNRLT-----ELPV
T27C10.5_Cele   -----------------PEYI------------WL-CPALKELNASYNRLS-----TLPM
GbpC_Ddis       -----------------PQSI-G---------D---------------------------
Pats1_Ddis      -----------------PEVL-G---------M---LENLIELDLSELDLSSSTNSGVGI
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     -----------------PIDI-F---------Q---IPTLEVLRVSNNDLD-----DNGI
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      -----------------PIEL-G---------T---LCKLNHLDISFNFIE-----TINV
Roco6_Ddis      -----------------HPSL-F---------P----EGIMRLNLSNNLFR-----EVEL
Roco7_Ddis      PHQKINPMILYINPQSTPQSIID---------K---FSKLIQPS----------------
Roco8_Ddis      -----------------PNVV-F---------Q---------------------------
Roco9_Ddis      -----------------PQAL-S---------L---CVGLEELYVQNNQIR-----ELPL
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      -----------------IQPA-KESTQDEIPRQWN-CMSLVNLDLSQNKLS-----SLPR
LRRKb_Spur      -----------------NKTR-P-------G--DT-AFKLVELDLSYNATV-----RFPS
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   -----------------PSYA-H----------WG-HTHLKVLNVSHNKLM-----GDA-
AqueK486_Aque   -----------------------------------------ELNLSNNKLI-----EIPD
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   -----------------GPDL-W-----------R-APLLKYLYASSNLLQ-----SLPY
AqueK489_Aque   -----------------PSSI-H---------SNV-ANSLQSLNLSNNNLT-----QLPS
AqueK490_Aque   -----------------PEDT-V---------W---------------------------
AqueK491_Aque   -----------------PIEV-W---------K---APKLQKLLLQKNRLE-----SFPS
AqueK492_Aque   -----------------------------------------ELNLSNNKLI-----EIPY
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   -----------------PQEK-I-----------V-LSHLIKFNLSNNSLT-----VFPI
AqueK495_Aque   -----------------PSML-----------RWN-CPKLKELNLSTNQLA-----DERR
AqueK496_Aque   -----------------PDSL------------WD-CITLHQLDVSSNSLS-----SLPR
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   -----------------PVL------------MWS-APKLSSLNCSHNTIQ-----EIPT


LRRK2_Hsap      NLTD-----------VVEKLEQLILEGN--------------KISGICS-P---------
LRRK1_Hsap      LFLH-----------SFKSLNSLNVSRN--------------NLKVFPDP-WA-------
CG5483_Dmel     PPMQ-----------TSSSLLSLDKL----------------NLQSFEEP-PS-------
LRRK2_Mmus      NLAQ-----------VVEKLEQLLLEGN--------------KISGICS-P---------
LRRK1_Mmus      QFMH-----------SFKSLTSLNVSRN--------------NLKSFPDP-WS-------
T27C10.5_Cele   VARA-----------SRGERPRLNNSNN--------------NFNT-QSP-TQE------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      P--T--------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     PKIC--------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      NSLS--------------------------------------------------------
Roco6_Ddis      PP----------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      GF-F--------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      QM-D-----------ACTSLITINLSEN--------------SFNEIPRP-WA-------
LRRKb_Spur      WLSM-----------FVPSLQRLSLASN--------------KIETIPDKP---------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   VHEW--------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   PELKN----------Q--------------------------------SSPLHAGD----
AqueK489_Aque   YF----------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   PFLS-----------PDSGFGTLEGMSSDGQVLHSSFSVPDS------------------
AqueK492_Aque   VHEW--------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   GLNGD----------QFPALRILMLNSN--------------SISLIEDKD---------
AqueK495_Aque   GIIK-----------GA-------------------------------------------
AqueK496_Aque   CGGLEDIREAALAKSTP---------------GILHL-ATAN--------------TS--
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   NLSY-----------VMENYDIIDIAGANGPPGA-SVTSPTQTLSGLSSP-RSKASTRRV


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      --CP--------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      --CP--------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      --CP--------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   -------------------------------------------LVS--------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------SLYPHTPVSPPFEAHTPYSGRKDSIHFLQQ
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   -----------------------TERRRSH------------------------------
AqueK496_Aque   -----AQAVFQNDLDCRESLYQASHRRRSK------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   STDPAGASIVQ--------------SYSDNCFTDDSSRTTDDNMIT--------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ----------------------------------------------LKCCK---------
CG5483_Dmel     ------------------------NKPRNVTQQRLTHRNLWSAT--LDI---TDNDMKWQ
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ----------------------------------------------LKCCK---------
T27C10.5_Cele   -------SNPIVV-----------DDPPNVTSNPLRRQNVWQAS--INL---SKVDD---
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ----------------------------------------------LEILN---------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   --------------------------PGSSKKEII-------HSLRYSFVDS---GL--E
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   SYIPHVQSSPVMSQSGITDRRVSLPPPHNIRRSRLR------ELFD-----ATDTDE--D
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------I-----------------
AqueK496_Aque   ------------------------------------------SS--RS---R---TK--K
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   --------------------------PDKVRQTRLY------DR--LNVCNA---NL--T


LRRK2_Hsap      ----------------------------LRLKEL----KILNLSKNHIS-----------
LRRK1_Hsap      ---------ASRNALECLP---D-KMAVFWKNHL----KDVDFSENALK-----------
CG5483_Dmel     HE-------------QDLG---DGKTAGVGSSQL----SSLNIANNLFT-----------
LRRK2_Mmus      ----------------------------LSLKEL----KILNLSKNHIP-----------
LRRK1_Mmus      ---------ASKNALESLP---D-KMAVFWKSHL----RDADFSENSLK-----------
T27C10.5_Cele   ---------------DSLF---P-DFPVTSSNTL----TTINLSFNKFH-----------
GbpC_Ddis       ------------------------------LVNL----KRLEVDNNHLV-----------
Pats1_Ddis      -----------------------------KLSKL----CILNLNQTRIV-----------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     -----------------------------TSTKL----RSLDLRKNHLT-----------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      -----------------------------QLVNL----KVLMMQRNYFN-----------
Roco6_Ddis      -----------------------------WFESL----LTLDISGNKLK-----------
Roco7_Ddis      ---------------------------------LLDTAHLGFY-----------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      -----------------------------KLGSL----RMLDLRNNQITKFKCHKLDDKS
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ---------ISKNMVQSAS---G-DLPKFWHRTL----RFLNLSYNRLT-----------
LRRKb_Spur      ----------------------------LALQLL----KILDLSNNKLT-----------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------SPGL----T---------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   REEDFHV--------------------RGQGFNL----EFLDLSDNKLT-----------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------SQ----------------------------
AqueK491_Aque   PFDDYEIAGIVDSTTSGNKEGK-------VLFQL----ETLDLSYNELT-----------
AqueK492_Aque   ------------------------------SPGL----T---------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ----------------------------LKLKSL----QELHISRNSIV-----------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   KGDDFKIRKLKEEVDSGEG-GDA-GIEMCDYSVL----TRLNLSKNRFK-----------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ---------IE---WDALE---G-KQ--EIFDGL----NNLNLSHNEIK-----------


LRRK2_Hsap      -----------------------------------------SLSENFLEACPKVESFSAR
LRRK1_Hsap      -----------------------------------------EVPLGLFQ-----------
CG5483_Dmel     -----------------------------------------SIPAALPC-----------
LRRK2_Mmus      -----------------------------------------SLPGDFLEACSKVESFSAR
LRRK1_Mmus      -----------------------------------------EVPLGLFQ-----------
T27C10.5_Cele   -----------------------------------------TFPFCLAC-----------
GbpC_Ddis       -----------------------------------------SLCS---------------
Pats1_Ddis      -----------------------------------------ELPKEFG------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     -----------------------------------------SIPEGIIN-----------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      -----------------------------------------RLPIEIFT-----------
Roco6_Ddis      -----------------------------------------HLGN---------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      CFLMNEIIHFRMGPNPLQKLSNQMFEMRSLIHLELTGCSLSTVPLKLLD-----------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      -----------------------------------------EIPTAICQ-----------
LRRKb_Spur      -----------------------------------------TLTPVFLH-----------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   -----------------------------------------AVPPGLPC-----------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   -----------------------------------------LIPQGLCC-----------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   -----------------------------------------ELPFAFLA-----------
AqueK495_Aque   ------------------------------------------EPTD-PH-----------
AqueK496_Aque   -----------------------------------------SFPIGLPC-----------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   -----------------------------------------VIPSNLPC-----------


LRRK2_Hsap      MNFLAAMPFLPPSMTI----------------LKLSQNK-F-------------------
LRRK1_Hsap      ---------L-DALMF----------------LRLQGNQ-L-------------------
CG5483_Dmel     ---------LAVNLTR----------------LNMSYNS-L-------------------
LRRK2_Mmus      MNFLAAMPALPSSITS----------------LKLSQNS-F-------------------
LRRK1_Mmus      ---------L-DALMF----------------LRLQGNQ-L-------------------
T27C10.5_Cele   ---------TCPRLLI----------------LNMSNNS-M-------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ---------DLKSLEK----------------LYLDFNS-L-------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ----------LVELQV----------------LTLADNQ-I-------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ---------RLKSLES----------------FSIAGSPCF-------------------
Roco6_Ddis      ---------LPFHLVR----------------VSIDDNH-L-------------------
Roco7_Ddis      -------------LRDIDDESSSPPSIKIPNNNSFAHNK-ISTMDIIECGPRLSYEFSIT
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ---------NLVNLEA----------------LYLNQNK-L-------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ---------L-SSLSE----------------LDLSHNV-L-------------------
LRRKb_Spur      ---------GCDALEQ----------------LCASNNQ-I-------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ---------------V----------------LNLSSNE-L-------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ---------LAPLLMT----------------LKLNNNS-I-------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ---------LAPKLLK----------------LHLHHNN-L-------------------
AqueK492_Aque   ---------------V----------------LDLSSNE-L-------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ---------GLNSLKV----------------LDASRNC-I-------------------
AqueK495_Aque   ---------SVPQQRV----------------LQLTSHN-L-------------------
AqueK496_Aque   ---------LAPNLFE----------------LDISDNN-I-------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ---------LCPKLTR----------------LDLSHNG-I-------------------


LRRK2_Hsap      ---------SCIP-----------------------------EAILN-------------
LRRK1_Hsap      ---------AALP-----------------------------PQEKW-------------
CG5483_Dmel     ---------RSMG-----------------------------HVTSY-------------
LRRK2_Mmus      ---------TCIP-----------------------------EAIFS-------------
LRRK1_Mmus      ---------LSLP-----------------------------PQEKW-------------
T27C10.5_Cele   ---------TSLP-----------------------------PMACV-------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ---------VTLP-----------------------------HSFRQ-------------
QkgA_Ddis       ---------TRFP-----------------------------MSIIN-------------
QkgA_C2d_Ddis   ---------TRFP-----------------------------MSIIN-------------
Roco10_Ddis     ---------SHLT-----------------------------SDIQ--------------
Roco11_Ddis     ---------NLFP-----------------------------KSIIT-------------
Roco4_Ddis      ---------SRFP-----------------------------MSITQ-------------
Roco5_Ddis      ---------HPIK-----------------------------QRIYEA------------
Roco6_Ddis      ---------ESID-----------------------------H----KVILRNKDLALKF
Roco7_Ddis      VNGTIQNILIDFD-----------------------------NQIDN-------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ---------SEIS-----------------------------IDFKR-------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ---------RCFP-----------------------------LPGTW-------------
LRRKb_Spur      ---------DSLPGDLDNILRKLKILKLAKNQLGLPEHPFIPKFVLH-------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ---------SSLP-----------------------------ADI---------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ---------KDFG-----------------------------NISDY-------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ---------SSLG-----------------------------TITDY-------------
AqueK492_Aque   ---------SSLP-----------------------------ADI---------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ---------EFISGEAAEYTCSLQDLKIGHNKLVEKEHEF-QTFIKT-------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ---------QVID-----------------------------I-TFL-------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ---------SDLA-----------------------------LPRAV-------------


LRRK2_Hsap      ----------------L--------------------PHLRSLDMSSNDIQY--------
LRRK1_Hsap      ---------------TC--------------------RQLKTLDLSRNQLGKNEDGLK--
CG5483_Dmel     ----------------P--------------------ATLKQLDLSHNEISCWPSLPRIT
LRRK2_Mmus      ----------------L--------------------PHLRSLDMSHNNIEC--------
LRRK1_Mmus      ---------------TC--------------------TQLKTLDLSRNQLGKNEDGLK--
T27C10.5_Cele   ----------------P--------------------AHLRTLDLSYNKIQESFIEA---
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ----------------L--------------------TNLEELSLSFNSMTEL-------
QkgA_Ddis       ---------------MC--------------------SQLVELDMSNNRITEI-------
QkgA_C2d_Ddis   ---------------MC--------------------SQLVELDMSNNRITEI-------
Roco10_Ddis     ---------------KL--------------------TSLTELNLNGNQIQSL-------
Roco11_Ddis     ---------------AC--------------------FNLAELDLSYNNIKEI-------
Roco4_Ddis      ---------------MC--------------------THLVELDLSDNKITEL-------
Roco5_Ddis      ---------------IA--------------------IKATKLDLSDCGLSAL-------
Roco6_Ddis      NQSFSDIVLERIYQCWY--------------------TGDPVLDLSGLGMCVV-------
Roco7_Ddis      ---------------VANIFYNIYQHLIELSPRSLSSSSSSSSDINNNNNNNT-------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ----------------L--------------------FKLSVLDLSDNQFTNV-------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ---------------SI--------------------RKLQHLNLAYNQLMHREAQPQ--
LRRKb_Spur      ----------------L--------------------PLLRDIDLSDNGII---------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ----------------P--------------------TLLKSLNLSGNGGEVAIVR--SR
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   --------------------------------------TLTNLDLSSNFLTSL-------
AqueK491_Aque   ----------------P--------------------SEIELIDGCHNQLTSAVAPARPR
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ----------------A--------------------LVIQSVDATSNGLL---------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ----------------P--------------------QILRKLSAKRCSLEKF-------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ----------------P--------------------SNLKQLNVSHNDILRLDSYKSRV


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ESDPHLLCYSCV-------QLPEGRDDDYKTAS--------------S-KGSSSSAT--S
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   -SPLHVVCHAVPPTTSNGSMLPKRRN-----SPARQHRSRSKSAVRSQ-RSLSVSRHHAL
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ---------------------------------------------------FSPHGPV-C
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ESLRNLTCAQ--------------------------------------KL-LQFAQET--
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------GNTL-------------------------------------TEGQLNSMRRK-C
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   E---QLPCTN-------------------------------------PKT-LINSGGT-I


LRRK2_Hsap      ---LP-------GPAHWK------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     FRA-SVLKSVCRHRRHLR------------------------------------------
LRRK2_Mmus      ---LP-------GPAHWK------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   IDP-QKEEESCVHKRHDS------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      -------------NNNIELTSSGRILTSNGSKHNSNNSNNSSGSSNISEQNLKRSSGIID
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      --DIP-------PPSEWK------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   LQSTPEKTLHCNHADHIL------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   -----MTPTRCSHRNHRV------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   --SIP-------PPYMWR------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   YYE--RQSNVCLHCSHSQ------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   YRD--PSKPFCSHRSHNH------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      SIINGHSNNNSNNYALALLSNSNFLPMFLPGQSKLQDYCFNVGDELILTEKTFVQLVEVL
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ----------SLNLREL----------------------------LFSHNQISILDLS--
LRRK1_Hsap      ---------------------------------------------------TKRIAF---
CG5483_Dmel     ----------LEALRTL----------------------------ILADNLLTRIQLSTD
LRRK2_Mmus      ----------SLNLREL----------------------------IFSKNQISTLDFS--
LRRK1_Mmus      ---------------------------------------------------TKRISL---
T27C10.5_Cele   ----------LEWLKTL----------------------------QLAGNRLRSISVTNA
GbpC_Ddis       -------LE---------------------------------------------------
Pats1_Ddis      ----PREVCFLINLKKL----------------------------MIEGNQIQFLP----
QkgA_Ddis       ----PIEITELKFLKN--------------------------------------------
QkgA_C2d_Ddis   ----PIEITELKFLKN--------------------------------------------
Roco10_Ddis     ----PPQLL---------------------------------------------------
Roco11_Ddis     ----PKEICQLKHLKI--------------------------------------------
Roco4_Ddis      ----PKDIQLLKSLRI--------------------------------------------
Roco5_Ddis      ----PIEIG---------------------------------------------------
Roco6_Ddis      ----PPILG---------------------------------------------------
Roco7_Ddis      ATPRRPPIALSSSLSQSNAFNSNVYNSNAYNSNVYNSNPYLSNYNGLSSQSLNSMN----
Roco8_Ddis      ----------LSNLEEL----------------------------SLAANQLSSIS----
Roco9_Ddis      ----PIHA-MLPSLKKL----------------------------YLHNNQLYNIS----
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ---------------------------------------------------TKQDNP---
LRRKb_Spur      ----------SQTLREV----------------------------ILSRNKIKKLTLG--
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   --------------------------------------------------------LSSP
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ----------LSNLQHL----------------------------NLSKNQLKDIMVESD
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ----PSS-----------------------------------------------------
AqueK491_Aque   ----------LRKLGYL----------------------------KLAHNKLVDVQLFRT
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ----------SRGLKHL----------------------------ILGSNKISSLDLS--
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ----------LQYLQTF----------------------------MLEDNRLKRFQLLKA
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ----------LISLAVL----------------------------DASHNQIADVKLYSP


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ---FTTRGRQ--------------------------------------------------
CG5483_Dmel     DAT---------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ---FTTRGRQ--------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ---KTSPVKKKNTPP---------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   SA----------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   APV---------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   TER------DHGTDLTSSIDEGRFSRRCKTGGMEMSIMHKDFTKSSFGTPLNNRIKGSSV
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   VLK------RTTRDP---------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   VHLVSDRGGK--------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      -------------------------------------------------RSGTEAASVLE
CG5483_Dmel     -------------------------------------TLF------NESEDADWSVVGVN
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      -------------------------------------------------RSGTETASMLE
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      --TSPTSPQPRQGVANFYAKLRAQRSPAKIIDANSRSTFYAHSPNG-G-SSRPEQWEKIE
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   -----------------------------------------------------HKKL-GG
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   --------------------------------------SF------------PHGLTPTH
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   SST-------------------------------D---------DGPSSDDKKPDSSSVE
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   -----------------------------------------------T-EDELEFRQNCS
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------IKVTDIPLF---AALA-S-ASGQSQDRVRQ


LRRK2_Hsap      EK----------------AYLWSRVEKLHLSHN-KL-KEIPPEIG-CLENLTSLDVSYNL
LRRK1_Hsap      FP----------------AFLSESLEVLCLNDN-HL-DTVPPSVC-LLKSLSELYLGNNP
CG5483_Dmel     RS----------------KVIFPNLSMLDMTNN-CL-KEIPASLH-ELSSLSVLNISGNV
LRRK2_Mmus      EN----------------PHVWSRVEKLHLSHN-KL-KEIPPEIG-CLENLTSLDVSYNL
LRRK1_Mmus      FP----------------AFLSESLEVLCLNDN-HL-DAVPPSVC-LLKNLSELYLGNNP
T27C10.5_Cele   AS----------------KVLLPALNVMDISDN-KL-LQAPPDVA-RLTLLSMLNLSGNT
GbpC_Ddis       --------------------RLSKLEVLSVNNN-KL-TLLPTSIA-SLSSLKTLNIKSNP
Pats1_Ddis      NE----------------ISQLSKLMILNVCKN-KL-DSLPASIG-QLSQLVSLNLNNNS
QkgA_Ddis       ---------------------------LNLSDN-LI-NDIPLEIC-NLTLLKV-------
QkgA_C2d_Ddis   ---------------------------LNLSDN-LI-NDIPLEIC-NLTLLKV-------
Roco10_Ddis     --------------------LLTNLKKLYLDNN-QL-QSISSAIH-RMQSLIELRLTNN-
Roco11_Ddis     ---------------------------LNMNNN-QL-DDLPLELA-NLTNLKY-------
Roco4_Ddis      ---------------------------LILRGN-LL-EDIPLEIC-YLGDLKI-------
Roco5_Ddis      --------------------SISSLIELDLTNN-RI-KDLPPQIG-KLSSLQTLNLSNN-
Roco6_Ddis      --------------------MLVHLTHLDLSGN-CI-SVLPPELA-NLTELVRLDLSFNI
Roco7_Ddis      VDGAGGVGGFNGEQNQQQNKVIARVRVIWAGSNSSV-DRLQSFIN-TSQNV---NTTYSG
Roco8_Ddis      ES----------------IGSLKSLEKLDLSFNKQI-NKIPKELG-LLVRLKSLNVLGSN
Roco9_Ddis      FN----------------DFNLPLLSELRLDGN-KL-TYVSPSIGTKLLSLTLLNLDRNP
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      FP----------------ECFAHSLYVLKLSHN-AL-EDVPPSVC-KLEALYDLDISCNP
LRRKb_Spur      DN----------------LKSWSKLERLILSHN-KL-TKVPKELG-QLTLLASLDLSHNR
LRRKa_Spur      ----------------------------------------------------TLQVDGNI
AqueK485_Aque   AG----------------TMFFTKLWSIDVSYN-EL-NVCPKWIL-ISRALMHLDLSGNT
AqueK486_Aque   --------------------VTPSIRTLNISYN-HF-CTVPLSVC-SFMSLQHLNISFNR
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   NQ----------------SLLYPKVQSLILSEN-KL-KRFPVGIH-KLERLGTLDVTDNI
AqueK489_Aque   --------------------KHSHLRSLDISSN-LF-SSVPDCLT-VMAHLTTLNISSNI
AqueK490_Aque   -------------------IQHSSLEVLQLSGN-KF-TSVPKTLC-RVRTLTTLDLSSM-
AqueK491_Aque   VL----------------YCLYPQLSTLDLGHN-KL-RSVPSHIH-LISSLAVLTISHNA
AqueK492_Aque   --------------------VAPSIRTLNISYN-CF-RTVPLSVC-SFKSLQHLNISFNK
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   DC----------------NKFWPHLERLVLSEN-KL-KELPVDIG-KLKTLTSLDISHNK
AqueK495_Aque   ------------------YSCVFSLTTVDLSNNPKL-TRLPDWVC-VLPHLVRLNLKGTP
AqueK496_Aque   AL----------------NLLYPSLEGLDLTSN-CLVGTFNPNIG-RQTQLKWLWLSQNK
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   LA----------------KLACPLLTRLVLHHN-QI-AEVPPSVC-DMTSLNSVDLSWNN


LRRK2_Hsap      ELRSFPNEMGKLSKIWDL---PLDELH--LN---------FDFKH-------IG--CK-A
LRRK1_Hsap      GLRELPPELGQLGNLWQL---DTEDL--TIS---------NVPAEI------QKE--G-P
CG5483_Dmel     NITELPPHLGLLSRLWNL---NTRGC--LLQ---------EPLRSMIE-----SKKHK-T
LRRK2_Mmus      ELRSFPNEMGKLSKIWDL---PLDGLH--LN---------FDFKH-------VG--CK-A
LRRK1_Mmus      GLRELPPELGQLGNLWQL---DIEDL--NIS---------NVPAEV------RKE--G-P
T27C10.5_Cele   AIKELPPDYGMLSRLWSL---SLKGC--SLK---------EPLESMVN-----VENCK-T
GbpC_Ddis       -----------------------------II---------TPPST------VV--SKG-L
Pats1_Ddis      QLVSLRPTMGLLSNLVEL---KLDGTR--LK---------TPPPE------IV--SLG-L
QkgA_Ddis       -----------------L---LLNENP--LN---------NFPSS------IV--ELG-T
QkgA_C2d_Ddis   -----------------L---LLNENP--LN---------NFPSS------IV--ELG-T
Roco10_Ddis     NISRLPPGIVALKKLNSL---ELTGNKP-LK--------DNIPEK------YI--QKG-K
Roco11_Ddis     -----------------L---AVQDNP--LN---------KFPHH------II--EQG-T
Roco4_Ddis      -----------------L---ELQENP--LN---------NFPLS------VV--QSG-T
Roco5_Ddis      AIESLPWQLSQLTTLKVL---NITGNP--ISFDGASNAKISIPDV------LS--GDD-L
Roco6_Ddis      -LTTLPLYIVSYKRLEHL---DLQGTLDTLV---------SPPRR------IA--ETGKL
Roco7_Ddis      STMALNDVLSNPNQLLST--------P--LS---------RPLLS-----------TV-I
Roco8_Ddis      KINELPSFLSTLPLLEQL---DFSRDI--IK---------SPPKE------IT--SKG-F
Roco9_Ddis      QITTLPHTLALLKKLKSL---IVNSNI--ME---------SPFRE------L----ET-T
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      DLHKLPEALSTLKHLFHL---KIEGL--DIK---------IP-SDVSQLSPQERS--K-T
LRRKb_Spur      SITTIPDELGQLNKLWEF---PLDGL--KLD---------LDP--A-----ILK--GR-T
LRRKa_Spur      NITTLPPEMGRLKCLYDF---NADGC--QLV---------EPLSSMI-----KT--SL-V
AqueK485_Aque   KIKSLPPELGLMSHLHTL---LFNGL--TLS---------DPPDPIP--------SLG-T
AqueK486_Aque   NIRSLPVEMGRLQNLIKL---VIDGLK--LR---------DPPRN-------VQ--RD-A
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   TIQSLPEKLHLLKNLIGF---RYKGI--G-----------DPIIGTL----DTF--KD-T
AqueK489_Aque   GIEIIPYELGNLRHLTFI---GMHRL--PY------------IK-N-----IPT--AN-K
AqueK490_Aque   PISSLPKEIEMLDKLANL---NVTDCN--IS---------DLPAG------A---LPG-R
AqueK491_Aque   SIDTLPLELSNLEGLWSL---EYDGV--PLT---------NPPASD-----LDK-FRS-A
AqueK492_Aque   NICSLPVEMGRLQNLIKL---VTDGLK-DLS---------DPPRN-------MQ--RD-A
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   DIRHLPNEMGKLDFLFYL---NLQGL--KNL----------D---I-----DQT--QN-A
AqueK495_Aque   KLQELPKALANFKDLSFI---SVDPQ--NFL---------SPPAKV------CS--QG-S
AqueK496_Aque   ELEKLPLHLADLKNFRRLTEIKLRNL-PSLV---------EPPKEY------QNESVQ-A
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   -IIELRPSLGKLGNLWEF---PLDGL--QLI---------SPPHNI------IDR-GK-T


LRRK2_Hsap      KDIIRFLQQRLK--KAVPYNRMKLMIVGNTGSG--KTTLLQQLMKTK-------------
LRRK1_Hsap      KAMLSYLRAQLR--KAEKCKLMKMIIVGPPRQG--KSTLLEILQTGR-------------
CG5483_Dmel     MDIVGYLKSIYE--DAQPYARMKLMVVGVAGIG--KSTLLDLLRQGA-------------
LRRK2_Mmus      KDIIRFLQQRLK--KAVPYNRMKLMIVGNTGSG--KTTLLQQLMKMK-------------
LRRK1_Mmus      KATLSFLRAQLR--KAEKCKLMKMILVGPPRQG--KSTLLEILQTGK-------------
T27C10.5_Cele   VEIVAYLKTILE--ESKTYHHLRLMILGSDGVG--KSVIWDALCKEA-------------
GbpC_Ddis       KDIVSFLRELET--GARPCLRSKLVVLGDPGVG--KTSVVQCMKGKK-------------
Pats1_Ddis      KSILLYLKDLIK--GQEQCYKMKLMIVGQENVG--KTTLLKTLKEKK-------------
QkgA_Ddis       KKLLSFCRNILEGKSCETWNKVKLMFVGEEGVG--KTRLCKLLIGSK-------------
QkgA_C2d_Ddis   KKLLSFCRNILEGKSCETWNKVKLMFVGEEGVG--KTRLCKLLIGSK-------------
Roco10_Ddis     EGIFSFFSETMR--TNVPCYRTRIIMLGDKSTG--KSNLIKCLKKLP-------------
Roco11_Ddis     KRTLVFLKNIIEGKKSETWNKVKLMFVGQEGVG--KSSLCKALMGSR-------------
Roco4_Ddis      KNLLLFCKNILERKKSETWNKVKLMFVGQEGVG--KTSLCQALKGSK-------------
Roco5_Ddis      IGILKYLKLAST--KEKPCMRMKLMLVGQENVG--KTSIAKCLKKEI-------------
Roco6_Ddis      IDIQRYFHDLFQ---GEPSYRVKLMIVGQENVG--KTSLVKCLKMKK-------------
Roco7_Ddis      AQDNTYICTS--KNDYCMNNQVKLCIVGEESQE--KLSFYNSLRKNY-------------
Roco8_Ddis      THIIGYLKDLFE--GTETLSHIKLMVLGSEKTG--RSSLVKALTKSQ-------------
Roco9_Ddis      DAILRYLTLQMQ--QSQFHPRNKLIIISDITNPQIKNEFIKNLTIAKPLTSKEREKEKEK
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      GQILKILHEKLL--DSQPYHSMKLMIMGPAKSG--KTTLLGSLMNDT-------------
LRRKb_Spur      KDIIGFLNQKYK--RSEAYNRMKLMVVGYGGRG--KSTLLSRMQGQK-------------
LRRKa_Spur      KDVLGYLRSILD--DAKPYTRMKLMFVGKAGIG--KTTLLNELRRDG-------------
AqueK485_Aque   QAILSYLHYKHK--SSQPITSLRVVLVGPESVG--KTSLVARLKGDP-------------
AqueK486_Aque   RDCVRYLNSKLR--STRRFYRMKLMLVGKQNRG--KTTLVTRLQGLD-------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   AQLLYYLRAREL--QAVSNTSMRLFVIGHANKG--KSTVLKTLRGER-------------
AqueK489_Aque   SSPLEFLKSRAR--TIQTITHYDVMVVSASNTS--PHIV-EAVYNA--------------
AqueK490_Aque   GWVRGFVKSRSR--SSKPCNIVKLIILSNSSVG--KVVLFSRLRQVI-------------
AqueK491_Aque   SDKLLYMRSLLH--DAKPYESMKLMLVGLQKQG--KTTLLTRLREIN-------------
AqueK492_Aque   RDCVRYLNNKLR--SARRFYQMKLMLLGKQNCG--KTTLVARLQGLD-------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   RAIIRYLKAKLT--QSKPCHVMKLTVVGSAAKG--KTTLLHNIINDK-------------
AqueK495_Aque   AAIIAYLRSQLR--GLSAYRHMNIMLLGWGD-E--KNKIAKELTSQQ-------------
AqueK496_Aque   SQLLTYMRSRLK--DSVPYRTLKLFFIGCGQRG--KTTLLRRLRERQ-------------
AqueK497_Aque   --------------TA--------------------------------------------
AqueK498_Aque   KDIIGFLWSLLQ--RARPYHRMKLMLVGKAGRG--KTTLLRKISEKG-------------


LRRK2_Hsap      --KSDL------------------------------------------------------
LRRK1_Hsap      --APQV-VH---------------------------------------------------
CG5483_Dmel     --GSGS-SS--SSH--R-SRASENHWAKRMGHARSTSRS--H----------------RH
LRRK2_Mmus      --KPEL------------------------------------------------------
LRRK1_Mmus      --APQL-AH---------------------------------------------------
T27C10.5_Cele   --VQKR-QP---------------------------------------------------
GbpC_Ddis       --KKTN-VT--S------SS--I-------------------------------------
Pats1_Ddis      --KKAT-P----------------------------------------------------
QkgA_Ddis       --YNKK-KS--SS----SSSSSLSSLSSALSSSSSSSSIINSNSIS--NSNINMVNIKNE
QkgA_C2d_Ddis   --YNKK-KS--SS----SSSSSLSSLSSALSSSSSSSSIINSNSIS--NSNINMVNIKNE
Roco10_Ddis     --KSSF-SS--S-------SSNLPSLNNLN-----------S-----------------N
Roco11_Ddis     --RRSS-SS---------FAAE--------------------------------------
Roco4_Ddis      --KKKA-EL--Q------------------------------------------------
Roco5_Ddis      --IPVG-KKLRQTIGLGTKKSKTPTLTEANGSIDFNAPQ--S----------------IN
Roco6_Ddis      --KFSK-NS---------DH--L-------------------------------------
Roco7_Ddis      --SQNG-L---LS----S-GGG---RGGGFFGS----NF-----IPSSTS----------
Roco8_Ddis      --TKSL-SR---------QSANF-------------------------------------
Roco9_Ddis      EKEKEK-EK---------KHKNI-------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      --SGRV------------------------------------------------------
LRRKb_Spur      --FDKK------------------------------------------------------
LRRKa_Spur      --VGAYIAQ--SL-----GTFG-ERQG----NSHI-----------------------SG
AqueK485_Aque   --VDG-------------------------------------------------------
AqueK486_Aque   --V---------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   --MTKE-N----L-----GV----------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   --CPHG-SH---------------------------------------------------
AqueK491_Aque   --EVRT-PI--STF--NERK-EGETVSAAV---S-----LKPGGITGASS------FFRR
AqueK492_Aque   --V---------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   --STKI------------------------------------------------------
AqueK495_Aque   --KRQT-QS---------------------------------------------------
AqueK496_Aque   --AGET-ER---------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   --QSGI-QE--NL-----FL---TRMS-------------------------------SD


LRRK2_Hsap      ----GMQSATVGIDVKD----------------------------WPIQIR---------
LRRK1_Hsap      --------GEATIRTTK----------------------------WELQRP---------
CG5483_Dmel     SSASSANISTVGVDIGT----------------------------WICEKR---------
LRRK2_Mmus      ----GMQGATVGIDVRD----------------------------WSIQIR---------
LRRK1_Mmus      --------SEATIRTTK----------------------------WELQRP---------
T27C10.5_Cele   -----IHSETGVIRQAE----------------------------WKFEAK---------
GbpC_Ddis       -NIGGSSGSEVGIEIDQ----------------------------YDFDVV---------
Pats1_Ddis      ---SGPNISTDGIAIDQ----------------------------WVFSCLFE-------
QkgA_Ddis       NQVTGDTVSTEGVNIH--------------------------------------------
QkgA_C2d_Ddis   NQVTGDTVSTEGVNIH--------------------------------------------
Roco10_Ddis     NSNNSGNSKTNILDIQD----------------------------WQCPIN---------
Roco11_Ddis     LQKSGDTISTEGVKIQ--------------------------------------------
Roco4_Ddis      --VTGDTVSTEGVKIQ--------------------------------------------
Roco5_Ddis      PLNTSLNISTDGINMDD----------------------------WRPP-----------
Roco6_Ddis      ----GTNVSTDGIDIDE----------------------------IKFNLD-----IELP
Roco7_Ddis      --NVNEVSSIDGVLHT--------------------------------------------
Roco8_Ddis      -L---KKVTSSEVSLND-----------------PIE-----IIQLKLDLPPEQQNG---
Roco9_Ddis      -GYGSKDKDKKGININYQQQHQQQQQYQQHQYSSQIGFNQNLPIKWEIDYENYPNSA---
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      --------LDMALHVTE----------------------------WELQDPVI-------
LRRKb_Spur      ----GDNIATVGVVVKE----------------------------WVIQI----------
LRRKa_Spur      KTLKGNHLSTVGVDVCE----------------------------WTYNK----------
AqueK485_Aque   ------INPTKGLEVSE----------------------------WKYKGD---------
AqueK486_Aque   ----SINQSTVGVDVSE----------------------------WHYAGG---------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   --MEEKRGVTVGIDVGR----------------------------WTCVHT---------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ---------LPEMDFFQ----------------------------WHYR-----------
AqueK491_Aque   IGSRDAPLSTVGVDLGL----------------------------WKYRKDLE-------
AqueK492_Aque   ----GINQSTVGVDVSK----------------------------WHYAGG---------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   -----ENTATLGVQIRK----------------------------WTYQQR---------
AqueK495_Aque   --------SLSSIERGS----------------------------YDYKGE---------
AqueK496_Aque   ---------TEGIDIEE----------------------------WSCRGA---------
AqueK497_Aque   -------QPIEGVDITV----------------------------W--------------
AqueK498_Aque   AKKFQKDLSTVGIVVSD----------------------------WTYTTK---------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      SNPSSNSLISNSLSNSSISSNNINSNNNINVHSNGGGINSNGVNSNSQININSSSGNIHS
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      NGGGVGNVNSSGGIHSNNSSGGGGGSNSFLNNTNSNGTNNNSSNLNINTNSNNVNSSGGG
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      -------------------------------------IMTSSSNLNLSTGT---------
Roco9_Ddis      -------------------------------------LYNLASTIHCTNSF---------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     -----------------------------------------------------------K
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   -----------------------------------------------------------R
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      --------------ELDE--------------------------TS--------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      NNYHPPVGTNTSMSNIQ--VIGSSGSNLGSGSNLSIGGSNGNNNNN--------------
Roco7_Ddis      ---------------------------------------------S--------------
Roco8_Ddis      --LPPPTQLSSSTSELKPQRKDSFGSS-----------------MT--------------
Roco9_Ddis      --ISQPIMISSSNQECTKLNKEEFLN------------------SR--------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ---------------------------------------------EGRGCSLTQKVKEKF
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   -----------------------------------------------------------L
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   --------------------------------------------PS--------------
AqueK492_Aque   -----------------------------------------------------------L
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   -----------------------------------------------------------T
AqueK496_Aque   -----------------------------------------------------------K
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   -----------------------------------------------------------H


LRRK2_Hsap      -----DKRKRDLVLNVWDFA--GR------------------EEFYSTHPHFMTQRALYL
LRRK1_Hsap      --AGSRAKVESVEFNVWDIG--GP------------------ASMATVNQCFFTDKALYV
CG5483_Dmel     ---RAPGSHGPVVFRTWDFG--GQ------------------KEYYATHQYFLSKRSLYL
LRRK2_Mmus      -----GKRRKDLVLNVWDFA--GR------------------EEFYSTHPHFMTQRALYL
LRRK1_Mmus      --AGSKAKVESVEFNVWDIG--GP------------------ASMATVNQCFFTDKALYV
T27C10.5_Cele   --SKGDKNLGPVGFSVIDFG--GQ------------------REYHSTHQYFLSKRSLNL
GbpC_Ddis       -FDEDDKKRRVITLSTWDIA--NQ------------------DVYFASSQLFDSERSVYI
Pats1_Ddis      QNGRLIKKKQDITLSIWDFA--GQ------------------EIYYTTHQFFLSERSVYI
QkgA_Ddis       -----DFKSKKVEFYAWDFG--GQ------------------QIFYPTHQFFLTTQSLYL
QkgA_C2d_Ddis   -----DFKSKKVEFYAWDFG--GQ------------------QIFYPTHQFFLTTQSLYL
Roco10_Ddis     VDGPDGKKKKTITIHLWEFE--GM------------------QND-ISH-VFFVPNIIYT
Roco11_Ddis     -----SIKGKKIDFYAWDFG--GQ------------------QVFYPTHQFFLTNQALYL
Roco4_Ddis      -----NIKNKKVEFHAWDFG--GQ------------------QVFYPTHQFFLTTHALYL
Roco5_Ddis      ----SEDQSPPVTFSIWDFA--GQ------------------EVYYSTHQFFISSRSVFI
Roco6_Ddis      SGGSGTMVNQRVTMSIWDCA--GQ------------------ELYYTSHQMFLTDSALYV
Roco7_Ddis      ELVVGSAEIDQITLKTFYIS--GN------------------EQYQVVHPLFISPQSLFI
Roco8_Ddis      TPEKKRPTKRNVKLMIYDFRMPSI------------------DVYYHTHQFFLSERAFYL
Roco9_Ddis      FNTQEISKKKNLTIFIRDLSQLNSSGSASASGNGSGNGNGIGISNTNCSQHLFSKRAVYC
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      SKEKEIVEGPAITFFSWDMK--GG------------------DLYENVHQCFVTAKTLYL
LRRKb_Spur      -------RKKDFCLSTWDFA--GQ------------------EDFYSTHPCFLTDHAADF
LRRKa_Spur      ----KKAKHGKVTFSTWDFG--GQ------------------QEFYATHQYFLTKRSLYL
AqueK485_Aque   -----VLRRNMVTFDLWDFT--GS------------------SRYKSVYSCFDCKDSLHI
AqueK486_Aque   -----G--RRKYQFSIWDFG--GV------------------EKYYATHQCFLSERSMYL
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ----RKKSAKPINFYTWDFA--GQ------------------DEYYVTHQCFLTNRALYL
AqueK489_Aque   ----IDRQSKRKHYSCLQFD--DD------------------AQFQIFQQFMSLPSSIYV
AqueK490_Aque   --PFKFFGIQKLIFNTWMVG--VQ------------------KDYRMLYPCLYTANALYT
AqueK491_Aque   YRGKKSVPLRSVTFYTWDFG--GQ------------------EEYYATHQCFLSNRSLYL
AqueK492_Aque   -----GRKKIEYQFSIWDFG--GQ------------------EEYCAIYQCFLSERSMYL
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   -------PGVQYSINCWDFA--GQ------------------EEFYSTHQCFLTPRTIYI
AqueK495_Aque   ----LDRNVVKVTYHTINFS--SE------------------AMEFTLYQCFLISRCIYL
AqueK496_Aque   -RRLFRAPQEPIQFLAWDFA--GQ------------------EVYQVTHQCFYSRRAIYL
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   HSDQTQTGLRNITFMTWDFG--GQ------------------EEYYATHQCFLSRRSLYL


LRRK2_Hsap      AVYDLSKG---QAEVDAMKPWLFNIKARAS-SS--PVILVGTHLDVSDEKQR-K--ACMS
LRRK1_Hsap      VVWNLALG---EEAVANLQFWLLNIEAKAP-NA--VVLVVGTHLDLIEAKFRVE--RIA-
CG5483_Dmel     VLWRISDG---HKGLAELLQWLGNIQARAP-NS--PVIIVGTHFDAVGESISP---QKAE
LRRK2_Mmus      AVYDLSKG---QAEVDAMKPWLFNIKARAS-SS--PVILVGTHLDVSDEKQR-K--ACIS
LRRK1_Mmus      VVWNLALG---EEAVANLQFWLLNIEAKAP-NA--VVLVVGTHLDLIEAKFRVE--RIA-
T27C10.5_Cele   VLWKITDG---DEALAQLDTWLVNIHARAP-NS--TVILVGTNLDQVASNSSKFGPGYID
GbpC_Ddis       VVFNLNND----D-FSAIEYWLHCIMSTSP-NS--PIVLVGTHIDAFENL-NV----VN-
Pats1_Ddis      VAWNCALA----EEESRVEFWLQSITTRAK-DA--PIIIVGTHLDDVNRTTA-K--MQK-
QkgA_Ddis       LIFRVNDS----NFAERVNYWVHQIKAKSG-ISLPIIFFVGTHIDSCTPEQL-S--MAE-
QkgA_C2d_Ddis   LIFRVNDS----NFAERVNYWVHQIKAKSG-ISLPIIFFVGTHIDSCTPEQL-S--MAE-
Roco10_Ddis     VCFNLSKFGSSKSNEQKITSYLHGINNYDK-KA--TIIIIGTHLDEISSNSK-K--QVD-
Roco11_Ddis     LVFKLTDP----NFAERVNYWTLQIKANSG-LSVPMIFLVGTHCDACTPEQL-S--SAE-
Roco4_Ddis      VVFKLTDP----NFAERVNYWVRQVKSNSS-GAVPAIFLVGTHSDVCTPEQL-Q--EAE-
Roco5_Ddis      VVFDMSVYNP--DETSRVPYWLQCIEAFGG-NS--PVILVGTHLDDLPNGVD-----VN-
Roco6_Ddis      VVWNLCKP----EVNSRVEFWLHSIRSKAE-NA--PILLIGTHLDDYLATHSES--ELD-
Roco7_Ddis      ITYNPMNI----NS-TMINYWLEIIQTKAQ-GS--TVYLVGLSNTSIDEKKF-V--SFK-
Roco8_Ddis      VTYDINKD----LSHSGLEFWVESIKKKAP-NA--PIYIVATHIDTFNQYGG-D--ILV-
Roco9_Ddis      LVWALSES----EEPTRIYKWLESIRDRCT-FA--TVFIVGLYNSDYCQDVPKD--YYT-
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      LVWDMSEG---MDGAHKLSSLLLNISSRSS-DF--GIVIVGTHHDVVQNSPV-D--MID-
LRRKb_Spur      IS--------------DMEMRVLEVC-R-------------------SPG----------
LRRKa_Spur      VVCKITDG---SKVINELQQWLVNIQARAP-NS--PVIIVGTHYDVILRDKKY---SKE-
AqueK485_Aque   AVFNINTG---Y---SEIISWLSDIQSFSEERV--PVLLVFTHLDSCQTREVRE------
AqueK486_Aque   LLWNVQHG---EEGIQELKPWLDAIALRAP-RS--CVLIVGTHLDCVEESDR-P--EV-D
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   LVWKLTDK---EQGLEGLHVWLRNIQ----------VLIIGTHLNAFRRAERG---NAD-
AqueK489_Aque   ILYDIGNP---SSLY----SVLSHLFLYSS-SP--TVIIAACSTDPFINDDHVK--MLEH
AqueK490_Aque   LVWDLTKT----GDINNIKLYVNSISRHFP-MA--NVLVIAILPEPYETWA-ES--NMP-
AqueK491_Aque   VIFNVCDG---EDGIDSLELWLHNIQARAP-ES--PVIIVGTHSDLLKE-DKEQ--RKQ-
AqueK492_Aque   LAWNVQDG---EEGIQELKPWLDNIALRAP-RS--CVLIVGTHLDSVEEGDR-P--EV-D
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   LAYNISKA---ESELDGLVPWLMNIEARAP-GS--PVIVVGTHRDMIADG----------
AqueK495_Aque   CIWNLSDG---KEGLQRLVPVLRNIQSMLP-GS--RVLFVIVHSEEKPELML-N--QIL-
AqueK496_Aque   ALFRMIDG---EEGINELEPWLRNVQLRAE-GC--IVIIVGTYLDKVSDSKV-A--EID-
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   VVWNVTHG---REGVLELKPWLLNIQARAP-NS--PVIIVGTHYDKVKRSQRH---LVT-


LRRK2_Hsap      KITK----ELLNK-----------------------------------------------
LRRK1_Hsap      T----LRAYVLALCRS-----PSGSRA---------------------------------
CG5483_Dmel     QLQQLIREKFIAIP---------DAEK---------------------------------
LRRK2_Mmus      KITK----ELLNK-----------------------------------------------
LRRK1_Mmus      T----LRAYVLALCRS-----PSGSRA---------------------------------
T27C10.5_Cele   IMEQKVRTRYMVA----------DADK---------------------------------
GbpC_Ddis       AVLESVASRFQ-------------------------------------------------
Pats1_Ddis      K---RMKEKYL-------------------------------------------------
QkgA_Ddis       S---ILKSN-F-------------------------------------------------
QkgA_C2d_Ddis   S---ILKSN-F-------------------------------------------------
Roco10_Ddis     KVFDCLSLKYK-------------------------------------------------
Roco11_Ddis     Q---ILKEN-F-------------------------------------------------
Roco4_Ddis      S---ILKAN-F-------------------------------------------------
Roco5_Ddis      QITQDIHSKYF-------------------------------------------------
Roco6_Ddis      EILENIYSKYF-------------------------------------------------
Roco7_Ddis      S---EYHR--L-------------------------------------------------
Roco8_Ddis      PLN-EIDQYLT-------------------------------------------------
Roco9_Ddis      FITPKIEQKCH-------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      -----LRSQLVEMLN----------VG---------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      Y-WPELKRTIFDRFIN-----IAHPQD---------------------------------
AqueK485_Aque   -SEKKSRSEWVKYN---------MSISKKPETSPAFTLLASSMSQTVKSLQDIDGRSSAH
AqueK486_Aque   KLLG----KVAELA----------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   SLLEGYKERIKKEFQY---------RD---------------------------------
AqueK489_Aque   QIKHSNWKQYR---------------E---------------------------------
AqueK490_Aque   QLNKKVHNLFS-------------------------------------------------
AqueK491_Aque   ELT-NYLEKLR---------------D---------------------------------
AqueK492_Aque   KLLE----KVAELV----------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   SW----ESEVLGVPEPISLYDETYSSS---------------------------------
AqueK496_Aque   KI---IKQKFF------------TKSS---------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   E----NVELINRLYGS---GSRLMHRQ---------------------------------


LRRK2_Hsap      -----------------RGFP---A-IR--DYH-FV------------------------
LRRK1_Hsap      -----------------TGFP---D-ITFKHLH-EI------------------------
CG5483_Dmel     -----------------IGLP---R-VI--DSI-EI------------------------
LRRK2_Mmus      -----------------RGFP---T-IR--DYH-FV------------------------
LRRK1_Mmus      -----------------TGFP---D-ITFKHLH-EI------------------------
T27C10.5_Cele   -----------------SGLP---R-IV--DVI-LI------------------------
GbpC_Ddis       -----------------KRFT---N-IQ--AII-SV------------------------
Pats1_Ddis      -----------------IRYQ---N-IK--AIK-LV------------------------
QkgA_Ddis       -----------------IKYS---R-VKQNVIN-FV------------------------
QkgA_C2d_Ddis   -----------------IKYS---R-VKQNVIN-FV------------------------
Roco10_Ddis     -----------------QLFP---T-LN--LVFHAV------------------------
Roco11_Ddis     -----------------VKYS---R-IRQNAIS-FV------------------------
Roco4_Ddis      -----------------VKYS---R-VKENTIN-FV------------------------
Roco5_Ddis      -----------------TKFP---N-VK--FFL-PV------------------------
Roco6_Ddis      -----------------RKF----R-LK--GIS-IL------------------------
Roco7_Ddis      -----------------FRFN---N-IN--SYS-NI------------------------
Roco8_Ddis      -----------------QRSL---E-VTG--VI-GV------------------------
Roco9_Ddis      -----------------NLFP---N-FTFS-FI-NILNNNNNNNNNNNNNNNNNNNNSGG
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      -----------------PGFP---P-VAG--IV-EV------------------------
LRRKb_Spur      -------------------FP---T-IKG--YI-NL------------------------
LRRKa_Spur      -----------------AGLP---H-VIA--CV-EV------------------------
AqueK485_Aque   ERIQSSLDQMEFSGHIVPLMP---LVIT--EPH-FV------------------------
AqueK486_Aque   -----------------QTYQNKLL-VP--EVL-AV------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   -----------------KIAP---K-IRG--VF-YV------------------------
AqueK489_Aque   --------------------------RV--TIA-TI------------------------
AqueK490_Aque   -----------------QR-----S-IRFHGLL-TL------------------------
AqueK491_Aque   -----------------LGLP---Q-IK--EVR-FV------------------------
AqueK492_Aque   -----------------QTYQNKLL-VP--EVL-AV------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   -------------------FP---H-DVT--FA-EV------------------------
AqueK495_Aque   -----------------YGYP---C-IGQ--RF-LI------------------------
AqueK496_Aque   -----------------NIYP---K-IIS--YI-SV------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   -----------------HGFP---T-IMY--NV-VV------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      NVVPVQPSINNSIDNNVENTNNNNNIINNNNNNNNNNNNNNNNNNSYNSNSNSNSNNNNN
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      NNSNNNNNNNINNNNINNNNNNNNNNNNNNNNNNNNNNSNNNSNNNSNSNSNSNSNNSNN
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      NNINNNNSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNDNDNNNNDNNNNLNNSNLNNNNG
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      -----NAT-----------EESDALAKLRKTIINESL-NFKI------------------
LRRK1_Hsap      -----SCK------------SLEGQEGLRQLIFHVTC-SMKDVG----------------
CG5483_Dmel     -----SC------------RTLHNIHLLANIIYDTAM-QLRSP-----------------
LRRK2_Mmus      -----NAT-----------EESDALAKLRKTIINESL-NFKI------------------
LRRK1_Mmus      -----SCK------------NLEGQEGLRQLIFHVTC-NMKDVG----------------
T27C10.5_Cele   -----NS------------TSRNDVKALLNTIYRTAW-EVRM------------------
GbpC_Ddis       -----SC------------TTGYDVDKLRQLIEDI-------------------------
Pats1_Ddis      -----SC------------TSGKGITSLREKLEAL-------------------------
QkgA_Ddis       -----SC------------VTGKGVKELKKRLIHE-------------------------
QkgA_C2d_Ddis   -----SC------------VTGKGVKELKKRLIHE-------------------------
Roco10_Ddis     -----STL------K----SDADGIRKLRRDIKQM-------------------------
Roco11_Ddis     -----SC------------TNGTGIKELKKILTNE-------------------------
Roco4_Ddis      -----CC------------ATGKGIKELKKRLIHE-------------------------
Roco5_Ddis      -----SC------------KSGKNINKLQNHIVKL-------------------------
Roco6_Ddis      -----SC------------STGVGFDNFLDLLKKT-------------------------
Roco7_Ddis      -----SL------------KNSKQIKQLVQRLQNN-------------------------
Roco8_Ddis      -----SS------------TTLRNIDLLKNEIIQTLL-NQSNNNNNNNNNNNYNNNK---
Roco9_Ddis      SNINISSS------N----NILGGMPKLREEIKNVFL-NFK-------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      -----DAR------G----SKNSGMAELKRVIYETAM-QMKVHH-----------K----
LRRKb_Spur      -----SAV-----------TDSGGINELRGMIENVIL-NEK-------------------
LRRKa_Spur      -----SCA------A---SSKSYNVNMLRDLVYDTAY-----------------------
AqueK485_Aque   -----SC------------TTGEGISQLRKTLYRIGAGSFRTT-----------------
AqueK486_Aque   -----GLM-----------NRLENIRTLREAIYNQAT-EYRG------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   -----GFGDPPFFGS---YLSPLRYEELSDKIHDIAC-SMEIPR-----------DS---
AqueK489_Aque   -----STD------QESLIGRSNSIHSLIELIDR--------------------------
AqueK490_Aque   -----SGS------P----SPRDNPVDVRMKIYEIAS-QM--------------------
AqueK491_Aque   -----GCP------T---SGKAEGVSELRVALWDVAF-SLTAPR-----------KK---
AqueK492_Aque   -----GLM-----------NRLENIELLREAIYNQAT-KYRG------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   -----SCV-----------GQKAGLDHLRNKIKEKID-SAK-------------------
AqueK495_Aque   -----NLS------V------GSEIEQLKAIIHQQAG-ELKVP-----------------
AqueK496_Aque   -----SCV------S----KFGNNMDKLRQLIYDVSV-HLKVSP-----------RDGIT
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   -----SCT------------SGSNINDLRDKIFDVAC-QVKENT-----------VTGRG


LRRK2_Hsap      ----------RDQLVVGQLIPDCYVELEKIILSERKN--V--------------------
LRRK1_Hsap      -------STIGCQRLAGRLIPRSYLSLQEAVLAEQQRRSRD-------------------
CG5483_Dmel     ---------GSKEPMLLQKIPASYIALEDIVNVIACNLRA--------------------
LRRK2_Mmus      ----------RDQPVVGQLIPDCYVELEKIILSERKA--V--------------------
LRRK1_Mmus      -------STIGCQKLAGRLIPRSYISLQEAVLAEQQRRSLG-------------------
T27C10.5_Cele   ----------GKERAMEQQIPSSYIALMKVTKELGVEFRK--------------------
GbpC_Ddis       ---------IKTQPYLKEKVPSSFFTLEEALIEVKKKR----------------------
Pats1_Ddis      ---------VQSQSNMGESLPRSYMLLENLVKEETKKR----------------------
QkgA_Ddis       ---------SEKSRLIKKDIPGSYIILEQRLSNRGANQGRMSISNSASN-----------
QkgA_C2d_Ddis   ---------SEKSRLIKKDIPGSYIILEQRLSNRGANQGRMSISNSASN-----------
Roco10_Ddis     ---------IAKNPILKQTYPASFMFLEDYLKEESNLM----------------------
Roco11_Ddis     ---------AEKSNLIKSNIPGSYLILEQRLTDRGANSSRILINQNNINQNNNNNNNNNN
Roco4_Ddis      ---------AEKSHLIKKDIPGNYMVLEARLTNRGANPGRMAVS----------------
Roco5_Ddis      ---------GKAEKKLGDLFSRSYFQLENLILSEREMN----------------------
Roco6_Ddis      ---------VVELPSLKQSLPELYLKLEKLIIKKRSTL----------------------
Roco7_Ddis      ----------AMMKQYHYKIPLSYSILKSQCQESVKEAYA--------------------
Roco8_Ddis      -----QSNSISTTNWLNERIPSIYITLETNLQEEAK------------------------
Roco9_Ddis      --------------PFGTKVSSSQKLFEKHI--KTL------------------------
LRRKd_Spur      ------------------------FNLKKRISEEVEVRQKA-------------------
LRRKc_Spur      -------RPVCVEKLIGRKVPQPYFNLKKRISQEVEVRQKA-------------------
LRRKb_Spur      ---------IKGQPIFGQMIPYSYLRLEQLLQEQVRRLKS--------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ---------HPALLTIGIEIPTMYLQVEDLIRQLRGHLKT--------------------
AqueK486_Aque   ---------NRSLPIMGQEIPASYFELNKELEKVQEEVRK--------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   -----DMPSSFSINLIDEKIPKCYLELEGAIQTLLEN-----------------------
AqueK489_Aque   ---------KGSFRRTTAIVPNSYSVLSEYTKSEATRLIE--------------------
AqueK490_Aque   --------SANGSQVTGRQYPENYYHLLPVLEREHTNLKT--------------------
AqueK491_Aque   -----GAIGGNKVKLLEQPVPSSYLRLEERMRELVVKCQSE-------------------
AqueK492_Aque   ---------KRSLPIMGQEIPASYIKLNEELEKVQEEVRK--------------------
AqueK493_Aque   ------------------EIPASYIKLNEELEKIREEVRK--------------------
AqueK494_Aque   ---------LRGQKIMGELVPASYLELSNILEEESRRLNKV-------------------
AqueK495_Aque   ---------NSSEKLIEEYVPRSYNGLQSHVESKIKLQ----------------------
AqueK496_Aque   LVHDPKLSLSSSYALLNQQIPRNFLELQERVSDLVKDLNES-------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   I---GCGRIPEYRLLMDQLVPASYLQLEDSVRSIALTLRLL-------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       --------------------------------SSSSLLNSSSSSSPSLTSKKSSSHLKHS
QkgA_C2d_Ddis   --------------------------------SSSSLLNSSSSSSPSLTSKKSSSHLKHS
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     HNNCNNNENCTTTAATAGTTTMTSTTTTTTNYSNENILNTSSNSLIALFT-------R-S
Roco4_Ddis      -------------------------------------------GSPI-GGG-SSAQ----
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------P-I----E--FPVIDRKRLL-QLVRE----NQL--Q--LDENELPHAV
LRRK1_Hsap      --------------D----D--VQYLTDRQLE-QLVEQ----TPDNDI--KDYEDLQSAI
CG5483_Dmel     ------------A-G----R--DPVLDGEQYK-RLVTEQMRLHNYKSF--RDAAELQQAT
LRRK2_Mmus      ------------P-T----E--FPVINRKHLL-QLVNE----HQL--Q--LDENELPHAV
LRRK1_Mmus      --------------D----Q--VQYLTDRQLD-QLVEQ----TPGNDI--KDYEDLQSAI
T27C10.5_Cele   ------------E-G----Q--PAVMTVEAYR-ERVKKRMISKFGRPF--RDDIEFYAAC
GbpC_Ddis       -------------------I--PPVMMWQEYI-NLANI-------CNL--KDSVQIQRAT
Pats1_Ddis      -------------------I--IPTIPWTEFI-QMGTI-------CTI--TDEAELLRAT
QkgA_Ddis       QQQQQQHQQQQQQ-LQQS--IKEKYIDYDDYL-NECKL-------SY---LKPHEIKDAT
QkgA_C2d_Ddis   QQQQQQHQQQQQQ-LQQS--IKEKYIDYDDYL-NECKL-------SY---LKPHEIKDAT
Roco10_Ddis     -------------------S--PPLVTKKTLQ-QMART-------MEL--HNEPHFTQLK
Roco11_Ddis     NS----NSNLSNN-YQKP-LVNQKYIDYNDFE-RECKL-------SH---LAQEEIQGAT
Roco4_Ddis      ---------LSSN-AINS--QKERYIDYDDYM-NECKL-------SH---LQPEEIKGAT
Roco5_Ddis      -------------------T--PPIITLSEFT-EMAIS-------CGI---PQTSITAAA
Roco6_Ddis      -------------------V--PPVLTWQSFS-QMVLS------NLDF--HDEIHVKVAT
Roco7_Ddis      ------------R-N----K--MPLSSIPLIK-NIARI-------FS---IEPRDSEAAI
Roco8_Ddis      -------------------K--RPIVTWDEYQ-NIAKL-------SNFTTSSYEKLVRAT
Roco9_Ddis      -------------------Q--TPFISKKELF-SIGEM----------CKLDKIETKNTC
LRRKd_Spur      ------------DPP----I--LPIMTKTELADDIVKL----IPDSGL--RTPIELQEAI
LRRKc_Spur      ------------DPP----I--LPIMTETELA-QIVQL----IPDSGL--HTPEELQEAI
LRRKb_Spur      ------------E-G----Q--PPVMLHKQVI-KMIRE----NDL--Q--LDDNELSQAV
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------V-KTEGEL--KPFHSFNDIR-ERLRR----PLKQLD--ITASDFLTVL
AqueK486_Aque   ------------G-L----R--APVMNAAQFR-ELVHR----LNLPDI--CSDEELRTAT
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------N-P----H--KPLYKRDAFC-KLKEV----RDI--I--KDEDEVDAAM
AqueK489_Aque   ------------D-N----K--APIVSSWDMW-ELVRS----SPHHDL--AGHKELSLVT
AqueK490_Aque   ------------S-G----Q--PGIMEEGTLW-SLLSS----AIDQDM--PDSMELPVMI
AqueK491_Aque   ------------V-D----V--SPVMKESEFF-EAVQD--------II--PNPRELNQAV
AqueK492_Aque   ------------G-L----R--DPVMTVAQFR-NLVHK----LNLTDL--CSDEELRTAT
AqueK493_Aque   ------------G-V----R--DPVMNVAQFR-NLVHK----LNLTDL--CSDEELRTAT
AqueK494_Aque   ------------K-S----N--FRVIRRSQLD-ELMRR----SSLTQG--MDSIELEQAV
AqueK495_Aque   ----------------------VTLVRYGEFV-DSFRSFS-HQSGDLS--DGGKEFTLAC
AqueK496_Aque   --------------Q----K--PPYLSHEEFS-SRF-------LSIFE--GDEEEMNEAV
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   --------------G----K--PPVLTYKEFK-EYVFGDA-RTLVSRD--VGDRELEQAV


LRRK2_Hsap      HFLNESGVLLHFQD-----PA--LQLS----DLYFVEPKWLCKIMAQILTVKVEG-CP--
LRRK1_Hsap      SFLIETGTLLHFPD-----TS--HGLR----NLYFLDPIWLSECLQRIFNIKGSR-SV--
CG5483_Dmel     TWCHENGVLLHYDD-----A----TLR----DYYFLDPQWLCDMLAHVVTVREIN-P---
LRRK2_Mmus      HFLNESGVLLHFQD-----PA--LQLS----DLYFVEPKWLCKVMAQILTVKVDG-CL--
LRRK1_Mmus      SFLIETGTLLHFPD-----TS--HGLR----NLYFLDPIWLSECLQRIFNIKGSR-SV--
T27C10.5_Cele   TFLHDCGELVRFED-----A----TLR----DLIFVDPLWLAEFLTSVVILRSP------
GbpC_Ddis       EFLHNIGSIVYFND-----L-NSSTVG----KMVILDQQWIINCMSSLITSKLLI-----
Pats1_Ddis      MFLHQLGSLVYFPK--------EPGLK----QFVILDPQWITTMLSSIITTKHS------
QkgA_Ddis       DFLHNLGIILHFDS---------PKLN----NLVVLDPQWLADVMSSLITFSHS------
QkgA_C2d_Ddis   DFLHNLGIILHFDS---------PKLN----NLVVLDPQWLADVMSSLITFSHS------
Roco10_Ddis     SLFNSLGSIALFEQFIRMEPGSTPQKT----EMIALNPIWIAKAIASLVCFNPQN-LPFN
Roco11_Ddis     EFLHNMGIILHYDT---------PILR----SLVVLDPQWLADVMSSLITFSHN------
Roco4_Ddis      DFLHNLGIILHFDT---------PTLK----NLVVLDPQWLADVMSSLITFSHN------
Roco5_Ddis      DFLKELGVIVYFDD-------PKSGLD----QFIFIDPPWLTRLMATIITSKPN------
Roco6_Ddis      KALVPLGSISFFDE-----P----GLD----QYVFLDPQWLTGVFSSIITTKHK------
Roco7_Ddis      KYLYEIGEVLYYRY-----EANDQLLN----ELVFLDSMWMSKLISAVLALKTQ------
Roco8_Ddis      NTLNRWGSIIWFED-----S--KSSLK----DFVILDPQWFSDCFYKLLLAKHS------
Roco9_Ddis      ELLTELGLLFWSED------------H----DWVILDPIWLSNTLNLLLTLKQS------
LRRKd_Spur      LFLHEIGSIVHFTD-----HL--NGLN----DLYFIDPVWLACTLQRVTALPI---GS--
LRRKc_Spur      NFLHEIGSIVHFTD-----HL--NGLN----DLYFIDPVWLACTLQRVTALPI---GS--
LRRKb_Spur      RFLHETGVLLHYDD-----PS--QQLR----NVYFIEPQWLCKVMARVITVREIN-PLV-
LRRKa_Spur      ---SLTGILLHYED-----S----MLN----DYFFLDPQWLCDTLAKVVTIPEIN-PDV-
AqueK485_Aque   RFLHKRGVVFLHDS-----P----RVDDRNSPVVAINPQIIGFLLQRTIRSGEMH-G---
AqueK486_Aque   LFLNDIRTILHYDD-----RS--HAIN----ELYFIDPQWLCKIMSQIVTVREKN-P---
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   HFLHNMGSVLHFPK-----P----NLE----EYYILSPQWWFDSCALVISPSNVN-ELIA
AqueK489_Aque   SFLQSISSILLLPA-----N--NSNER----DCYVLNRQWFVRAMSGLLRNHQ-N-LRI-
AqueK490_Aque   SFLKESGYLMHFDD-----P--NCRLN----QFHFLHPEWLVFTVHKLLHHLNYY-----
AqueK491_Aque   TFLHENGVLLHYAT-----P----ALN----HLYFIDPQWLCDMLAHVVTIPEVN-RFIQ
AqueK492_Aque   LFLNDIGTILHYDD-----RS--HGIN----ELYFIDLQWFYKVMCEIVTVREKN-S---
AqueK493_Aque   LFLNDVGTILHYDD-----RS--HGIN----ELYFIDPQWLCNMMSEIVTVREKN-P---
AqueK494_Aque   KFLHECGTLLHYDD-----IQ--SNLS----DLYFLDPQWLCSVMAKIITMKHLT--I--
AqueK495_Aque   QFLHDSGTVYHYHA-----PN-TNPTA----DLFILNLQWLCNTLAKILYKAK-NG----
AqueK496_Aque   NYLTLQGTLLHFDD-----Y----GLR----DLYFLDPQWLAKLMARLISPNSAKNMS--
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   RFLHDNGTLLHYDD-----P----LLK----ELYFVDPQWLSDMLAHIVTVREIN-PF--


LRRK2_Hsap      --------------KH-P------------------------------------------
LRRK1_Hsap      ---------------A-K------------------------------------------
CG5483_Dmel     --------------FA-P------------------------------------------
LRRK2_Mmus      --------------KH-P------------------------------------------
LRRK1_Mmus      ---------------A-K------------------------------------------
T27C10.5_Cele   --------------NL-P------------------------------------------
GbpC_Ddis       --------------NN-C------------------------------------------
Pats1_Ddis      --------------YA-K------------------------------------------
QkgA_Ddis       --------------WI-K------------------------------------------
QkgA_C2d_Ddis   --------------WI-K------------------------------------------
Roco10_Ddis     VSVSAEEANDASHDST-I------------------------------------------
Roco11_Ddis     --------------WI-K------------------------------------------
Roco4_Ddis      --------------WI-K------------------------------------------
Roco5_Ddis      --------------FV-Q------------------------------------------
Roco6_Ddis      --------------FI-K------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      --------------FINS------------------------------------------
Roco9_Ddis      --------------SSAPSTPPQIPLNSTNLNNTSIPSQITTTSTNSSSTSTSTSTSTST
LRRKd_Spur      ---------------L-K------------------------------------------
LRRKc_Spur      ---------------L-K------------------------------------------
LRRKb_Spur      ---------------S-K------------------------------------------
LRRKa_Spur      -----------------K------------------------------------------
AqueK485_Aque   ------------EGSI-L------------------------------------------
AqueK486_Aque   --------------FI-K------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   -----------AGDEP-G------------------------------------------
AqueK489_Aque   -----------------A------------------------------------------
AqueK490_Aque   --------------HA-N------------------------------------------
AqueK491_Aque   -----------RGSGP-E------------------------------------------
AqueK492_Aque   --------------FI-K------------------------------------------
AqueK493_Aque   --------------FV-K------------------------------------------
AqueK494_Aque   ---------------I-S------------------------------------------
AqueK495_Aque   -----------------S------------------------------------------
AqueK496_Aque   ---------------L-V------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ---------------V-K------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      STSTSTSTSTSTPLQTPTSLVSLSNISLSTISIPIQPNTSSILLDSSMNDSFNKESSGSN
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ---------KGIISRRDVEKFLSK----KR----K---FP--KNYMSQYFKLLEKFQIAL
LRRK1_Hsap      ---------NGVIRAEDLRML-LV----GT----G---FT--QQTEEQYFQFLAKFEIAL
CG5483_Dmel     ---------TGVMKLDDLQML-FR----S---V-Q---V--Q------------------
LRRK2_Mmus      ---------KGIISRRDVEKFLSK----KK----R---FP--KNYMMQYFKLLEKFQIAL
LRRK1_Mmus      ---------NGVIQAEDLRML-LV----GT----G---FT--QQTEEQYFQFLAKFEIAL
T27C10.5_Cele   ---------AGLLSTDAINPH-TR----SFK-S-G---A--LLMLKTQLLDLLHKFELAL
GbpC_Ddis       ---------NGIVRQSDLELV-WK----AP----T---YP--EHLHPALLSIMQAFEICR
Pats1_Ddis      ---------DGILNHKSLKQI-WR----PP----Q---YP--THLHPHLISLLEKFEISY
QkgA_Ddis       ---------LGILNHSDLQSI-WG----G-----R---YK--QTLWPSLLKLLEKFEVSY
QkgA_C2d_Ddis   ---------LGILNHSDLQSI-WG----G-----R---YK--QTLWPSLLKLLEKFEVSY
Roco10_Ddis     ---------TGILPHRVLRYV-WG----TNS-KYY---VP--ERFFSLFLSLLESNDLAI
Roco11_Ddis     ---------NGILNHSELVSI-WS----G-----K---YD--QSIWPSLLKLLEKFEVSY
Roco4_Ddis      ---------RGILNHSELVAV-WG----G-----K---YD--QSLWPLLLKLLEKFEVSY
Roco5_Ddis      ---------SGVLDQSNLHQI-WK----PP----D---FP--QHLHHVLLAILQKFEIVH
Roco6_Ddis      ---------DGVLKKSDLYQI-WK----PP----H---FIEDEGLHSLLINLLERFELMF
Roco7_Ddis      ---------NGMTVVDQITQA-WA----S-----L---FP--HCKTSSLLFLLEKFELVY
Roco8_Ddis      ---------DGILLLSNLKNI-WK----PN----I---VP--EQFHIKLLKLLERYQILY
Roco9_Ddis      KVANPTIRKRDIILMSNLEGI-WN----------D---IP--TRLYPYLLTLAKKFNIAY
LRRKd_Spur      ---------GGKVHVETLREL-SK----KS----S---IE--EDKFEQYLQLLARFEIVV
LRRKc_Spur      ---------GGKVHVETLREL-SK----KS----R---IG--EDKFEQYLQLLARFEIVV
LRRKb_Spur      ---------EGIMKVKDISLL-FN----DG----D---VP--KQLIPQYLKLLERFEVSL
LRRKa_Spur      ---------KGVMLVRDLHRK-FE----DS-------------SVKEFIVSLLNKFEVAV
AqueK485_Aque   ---------SGFLPNVHPAMI-WGVDPVLFADDNN---S--AGITGLQLIDFLTSVDLCA
AqueK486_Aque   ---------NGILHSRNVPFI-FC----DP----R---FQ--WKYFEQYLSLLDRFGIAL
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ---------SGLLRFQMMQVM-FS----EK----K---VS--SEQAKLIFSFLHQYGVLL
AqueK489_Aque   ---------NGLYPVRNLCDL-LH-----P----Y---FS--TDIPYAVYTVASLLSLAI
AqueK490_Aque   ---------HPIVTLHKLVSL-LK----L-----G---GE--KRLTTAVIRLLIRFHIVL
AqueK491_Aque   ---------AGILKTSVLSHI-FK----GK----L---FP--HTLRNEYIELLSKFEVAL
AqueK492_Aque   ---------NGIFYSRNVPFL-FR----DP----K---FQ--WEYFERYLTLLDRFEIAL
AqueK493_Aque   ---------NGIFYSRNVPFL-FR----DP----R---FQ--WEYFGCYLTLLDRFEIAL
AqueK494_Aque   ---------KGMLRKKDLPLI-LR----GS----Q---FP--PDFSSEYIRLMEWFDVAL
AqueK495_Aque   ---------APVLSMTVLQSL-LC----SI----G---LV--TNYHSALIGIMIKYNKLV
AqueK496_Aque   ---------DGKILLSSL----FE----QD----LFLSEH--RAIASKYLQLLQKFEVAL
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ---------DGIMKIKDFTLL-FN----DK----D---FP--IHWQKQYLRLLTTFEVAV


LRRK2_Hsap      P--IGEE-----------------------------------------------------
LRRK1_Hsap      P--VAND-----------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      P--IGEE-----------------------------------------------------
LRRK1_Mmus      P--VAND-----------------------------------------------------
T27C10.5_Cele   A--TQPR-----------------------------------------------------
GbpC_Ddis       S--LSPSD----------------------------------------------------
Pats1_Ddis      N--LSPDS----------------------------------------------------
QkgA_Ddis       Q--LPNL-----------------------------------------------------
QkgA_C2d_Ddis   Q--LPNL-----------------------------------------------------
Roco10_Ddis     N--IYSLEVNNNNNNNSNGNNVGRGRSGSRSMSIHEANRSNSYFGVNLNNTSSLSSFTSN
Roco11_Ddis     E--LPNEF----------------------------------------------------
Roco4_Ddis      E--LPNI-----------------------------------------------------
Roco5_Ddis      P--LPDPK----------------------------------------------------
Roco6_Ddis      P--LDSDL----------------------------------------------------
Roco7_Ddis      I--SAED-----------------------------------------------------
Roco8_Ddis      T--LKNNS----------------------------------------------------
Roco9_Ddis      Q--IDTLY----------------------------------------------------
LRRKd_Spur      P--ISHH-----------------------------------------------------
LRRKc_Spur      P--ISHH-----------------------------------------------------
LRRKb_Spur      P--VSDD-----------------------------------------------------
LRRKa_Spur      T--YDPK-----------------------------------------------------
AqueK485_Aque   P--LVPG-----------------------------------------------------
AqueK486_Aque   P--LDNR-----------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   P--VDKE-----------------------------------------------------
AqueK489_Aque   P--VTSH-----------------------------------------------------
AqueK490_Aque   P--ISNS-----------------------------------------------------
AqueK491_Aque   L--LDRN-----------------------------------------------------
AqueK492_Aque   P--LNNR-----------------------------------------------------
AqueK493_Aque   P--LNNR-----------------------------------------------------
AqueK494_Aque   Q--YSNE-----------------------------------------------------
AqueK495_Aque   PLDIGRS-----------------------------------------------------
AqueK496_Aque   C--IGDK-----------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   E--FKEG-----------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       -----------------L------VRPEEVNEKE--------------------------
Pats1_Ddis      -----------------T------S-----------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     QKVRNGRSSSFNARVGWA------LVSSLLAPPP--QLSIN-------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      -----------------A------TISSSSSSPSTTQKSLNN------S-----------
Roco6_Ddis      -----------------V------SLSSSNGNNGN---SYVNNNNNNNNNSNNNNNGSNK
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      -----------------N------LQQLQQQQQQ--QKSFGNLSKENSL-----------
Roco9_Ddis      -----------------DPTSWGFVYPSP-------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------GSN-LKSSGSAISTSSSSTTNGNKTLHRTNSTTNTT
Roco6_Ddis      SS-----PFKTTPSSPSTLRLVDSKSKGSHSSNPILS-----------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      -NSMSYSIESRSSSSPL-PTVVTLSAE-ISSS-PSLSLSNS----SQSVF----------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      SLLNVSRFGNGSIS-------------------------------------------KGS
Roco6_Ddis      -------------GNNSSSKNSTSTK----------------------RSISGSP-----
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      -------TNPNNNNNNKSEQQQ---------QQQQQQQ--------QPQPISTSPKLLRN
Roco9_Ddis      ------------ISNQQQQQQQQ-SSTQHQHQHHHHQQQQQTSINLNRLSISGSPSLRSI
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      SL----------------------------------------------------------
Roco6_Ddis      -------------------------------LRSRSNS----------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      SLKNLKSIENNSSSLSNNSILNSNSNSSGNLLQNGS------------------------
Roco9_Ddis      SIRNGGNINTLNSSGSNNSSPLKFPNLALSPIRNGSNSNLTHHHGSNSSLNNLLSPLKNL
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ---------------------------------------------------YLLVPSSLS
LRRK1_Hsap      ---------------------------------------------------SYLLPHLLP
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ---------------------------------------------------YLLVPSSLS
LRRK1_Mmus      ---------------------------------------------------SYLLPHLLP
T27C10.5_Cele   ---------------------------------------------------QLLIPSLLP
GbpC_Ddis       -----------------------------------------------VMGDRNLVPNLLS
Pats1_Ddis      -----------------------------------------------FETGTSLIPSLLL
QkgA_Ddis       --------------------------------------------------SKSLIPSLLP
QkgA_C2d_Ddis   --------------------------------------------------SKSLIPSLLP
Roco10_Ddis     ---------------------GNCSISSNSS----SSSSSLSNA-LNLNNISSMIPII--
Roco11_Ddis     -------------------------------------------------PSRSLIPSLLP
Roco4_Ddis      --------------------------------------------------AKSLIPSLLP
Roco5_Ddis      -------SIIKKINDQSTSPSNSTTPSPNTSSNNFSDSITL----VPKSSTKHLVPILLS
Roco6_Ddis      --------DLDLIGGGGGSPINGSSIDY------SSKSNTLTPGLFNELNQKFIIPSQLP
Roco7_Ddis      --------------------------------------------------SSVIIPQLFG
Roco8_Ddis      ----------------------------------------------YISFNRIIIPCLLP
Roco9_Ddis      QLQQKYDK-----------------------------------L-KLLNEKVIFLPNELP
LRRKd_Spur      ---------------------------------------------------WYLVPARLP
LRRKc_Spur      ---------------------------------------------------WFLVPARLP
LRRKb_Spur      ---------------------------------------------------KILLPCKVP
LRRKa_Spur      ---------------------------------------------------HLLIPSRLP
AqueK485_Aque   ---------------------------------------------------AVLIPSLLP
AqueK486_Aque   ---------------------------------------------------QILIPSMLP
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ---------------------------------------------------TALVPSMLS
AqueK489_Aque   ---------------------------------------------------NILIKSMLQ
AqueK490_Aque   ---------------------------------------------------AYLIPSLLP
AqueK491_Aque   ---------------------------------------------------RMLVPSMLP
AqueK492_Aque   ---------------------------------------------------QILIPSMLP
AqueK493_Aque   ---------------------------------------------------QILIPSMLP
AqueK494_Aque   ---------------------------------------------------LILIPSYLP
AqueK495_Aque   ---------------------------------------------------RFLFPSLLP
AqueK496_Aque   ---------------------------------------------------EVIIPSLFP
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ---------------------------------------------------KLLIPSHLP


LRRK2_Hsap      DHRPVIE-----------------------------------------------------
LRRK1_Hsap      SKPGLDT-----------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      DHRPVIE-----------------------------------------------------
LRRK1_Mmus      SKPGLDT-----------------------------------------------------
T27C10.5_Cele   DEYRLRS-----------------------------------------------------
GbpC_Ddis       DNTN-IV-----------------------------------------------------
Pats1_Ddis      NDRPAIF-----------------------------------------------------
QkgA_Ddis       DDPIGEI-----------------------------------------------------
QkgA_C2d_Ddis   DDPIGEI-----------------------------------------------------
Roco10_Ddis     -DLPGI------------------------------------------------------
Roco11_Ddis     EEPIDRI-----------------------------------------------------
Roco4_Ddis      EDAEGEI-----------------------------------------------------
Roco5_Ddis      EERPNSI-----------------------------------------------------
Roco6_Ddis      EIRPSFG-----------------------------------------------------
Roco7_Ddis      GERPMVM-----------------------------------------------------
Roco8_Ddis      NGKPSHL-----------------------------------------------------
Roco9_Ddis      NEPPMSM-----------------------------------------------------
LRRKd_Spur      RDNPGVM-----------------------------------------------------
LRRKc_Spur      RDNPGVM-----------------------------------------------------
LRRKb_Spur      IQKPNIT-----------------------------------------------------
LRRKa_Spur      QEGVDTTIIPVFRSRSDSTRVYRKTGARSPSPIQSSPPERWNRKAVRGHSPSPSRIYCHD
AqueK485_Aque   RLPPAET-----------------------------------------------------
AqueK486_Aque   DKRPEKA-----------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   PIPTVKLFT--GQG-------------YFPRSV-----------------S--S------
AqueK489_Aque   SANNDPI-----------------------------------------------------
AqueK490_Aque   HNPPPLA-----------------------------------------------------
AqueK491_Aque   SAPKQTL-----------------------------------------------------
AqueK492_Aque   DERPEKA-----------------------------------------------------
AqueK493_Aque   DERPENA-----------------------------------------------------
AqueK494_Aque   KEKPDSI-----------------------------------------------------
AqueK495_Aque   SLPPPHS-----------------------------------------------------
AqueK496_Aque   ESQSYPK-----------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ELKPALS-----------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      GSPTDGSSPR--ETSPETVETPERSPATMSIPVPIRRNLQGKARMANCASSPPCEMYSEA
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ----SSSSAYSEDIRSFFDDLPA------ALP----------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      STSTMGLDAMDTPTFELLRKSATITKSPSSGDVNTGTVKGKLDRADIELVSNKAQDSKVP
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------L--P--------------------------------------------------
LRRK1_Hsap      -----HG--M--------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------L--P--------------------------------------------------
LRRK1_Mmus      -----HS--M--------------------------------------------------
T27C10.5_Cele   -----DF--LAS-----AVKIRMKMSQWNVRCPSPAGSPTKSPL-------RRTSPTDQN
GbpC_Ddis       -----AQ--W----------------------------------D---------------
Pats1_Ddis      -----PS--LW---------------------------------G---------------
QkgA_Ddis       -----LE--IK---------------------------------D------------R--
QkgA_C2d_Ddis   -----LE--IK---------------------------------D------------R--
Roco10_Ddis     ----------W---------------------------------E------------A--
Roco11_Ddis     -----QE--IK---------------------------------E------------K--
Roco4_Ddis      -----ST--IK---------------------------------D------------R--
Roco5_Ddis      -----EK--LY---------------------------------D------------Q--
Roco6_Ddis      -----LL--W----------------------------------P---------------
Roco7_Ddis      -----RD--LW---------------------------------S---------------
Roco8_Ddis      -----AS--LW---------------------------------D---------------
Roco9_Ddis      -----DK--MF---------------------------------L---------------
LRRKd_Spur      -----LS--PH---------------------------------N---------------
LRRKc_Spur      -----LS--LH---------------------------------N---------------
LRRKb_Spur      -----LP--I--------------------------------------------------
LRRKa_Spur      SPFDGYK-FTP-------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   -----DI--P--------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   --SLSRK--LQ-------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   -----MI--Q--------------------------------------------------
AqueK491_Aque   -----YN--FKTLFPRPPIAYLL--QQSRIHSSSSLSDNRMSPYSSQSDPLMVRLPPK--
AqueK492_Aque   -----DI--P--------------------------------------------------
AqueK493_Aque   -----DI--P--------------------------------------------------
AqueK494_Aque   -----T---L--------------------------------------------------
AqueK495_Aque   -----SYD----------------------------------------------------
AqueK496_Aque   -----PNDSLK---------------------------------D---------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   -----HC--YP---------------------------------P---------------


LRRK2_Hsap      --------------HC-ENSEIIIRL-YEMP-YFPMGFWSRLINRLLEISPYMLSGRE--
LRRK1_Hsap      --------------RH-PTANTIQRV-FKMS-FVPVGFWQRFIARMLISLAEMDLQL---
CG5483_Dmel     -------------GNG-NRSQGLRRI-LLMT-YFPSGFWSRLITRILADEQIIEAIR---
LRRK2_Mmus      --------------HC-ENSEIIIRL-YEMP-YFPMGFWSRLINRLLEISPFMLSGRE--
LRRK1_Mmus      --------------RH-PMANTIQRV-FKMS-FVPVGFWQRFIARMLISLAEMDLQL---
T27C10.5_Cele   GVGSEDVML---QFTY-DDDQLLRRI-YALA-YIPSGFWSRLVTRIVGDKNVCAAIE---
GbpC_Ddis       ------------DFID-PDTILLNRQ-YHLP-FLPEKFFGKLIIHLMNFTKVESC-----
Pats1_Ddis      -------------SFN-QLVRQFGRI-YQFE-FVPNGFFSRLMVRILNFARVE-------
QkgA_Ddis       ----EWVPLKL-AMEN-NYVQVFGCD-YHFS-FMPLGFFARLLLRILLIQGID-------
QkgA_C2d_Ddis   ----EWVPLKL-AMEN-NYVQVFGCD-YHFS-FMPLGFFARLLLRILLIQGID-------
Roco10_Ddis     --------F----PES-PEIHQFSRR-FSLD-VIPNGLFGRLLSRLMQHAHL--------
Roco11_Ddis     ----LWIPLPE-AIES-KRVQIFGCQ-YNFD-FMPLGFFPRLLLRILLIKGID-------
Roco4_Ddis      ----EWVTLPQ-AIES-GRCQVFGCD-YNFD-FMPLGFFARLLLRILLISGVE-------
Roco5_Ddis      ----I--LL----KSQ-QQQPFLERI-YQFE-FLPIGFFSKLMIRTMHFTTV--------
Roco6_Ddis      ------------S-LD-HSRVEFNRW-IQLS-FAPAGLFSRLLIRLLISKEFDMK-----
Roco7_Ddis      -------P------TA-HANNEYLRI-YEFQ-FLPKGFFSRLSVRVLQHYDP--------
Roco8_Ddis      ------------TWSG-EDEHQIGRY-YQFRNISAKNCFERVMVRFLYMME---------
Roco9_Ddis      ------------D--V-GEPRSLCRI-FQFEKKIPSSFFPRLLSQLYMFCS---------
LRRKd_Spur      -------------TDD-APFHYLRRI-YKMP-YLPPGFWIRLVSRLIADLQMRDKK----
LRRKc_Spur      -------------TDD-APFYYLRRV-YKMP-YLPPGFWIRLVSRLLADLQMHDKK----
LRRKb_Spur      --------------SD-ATQDLLLRY-YDMP-YIPLGLWSRMILRLLLFSKHM--MN---
LRRKa_Spur      --------------VE-NLKTAIRRL-YILQ-YIPSGFWSHLISRLLSDQMIPGLIN---
AqueK485_Aque   ------------VLNL-ED-LSPKRV-YILG-YLPSFFWCHLLSRVLRALAFHRFLQ---
AqueK486_Aque   --------------DD-KSAPFYIRFINFQS-STPPGFWSRLISRIMHTVPQVCRALD--
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   --------------IK-TTGLVYRRL-FLLP-PLPTGFWSKLITLCLQKNDFVKIIV---
AqueK489_Aque   ------------ASDL-SSQYQIQRL-YKFE-SLPMSLWPRLLSHLLINMNGMINRLT--
AqueK490_Aque   -----------------VGCYRRQFI-PKGR-PLPEDFWFYLISHLLFHLPRLLKPDDST
AqueK491_Aque   ----SFSPMSPTTPDLYRTGLLLRRF-YFMK-YVPSGFWPRLISRFLTSSDFAVIVLK--
AqueK492_Aque   --------------YD-KSAPLYIRFINFQS-SSPPGFWSRLISCIMHTVPQVCRALD--
AqueK493_Aque   --------------YD-KSAPLYIRFINFQS-SSPPGFWSRLISRIMHTVPQVCRALD--
AqueK494_Aque   --------------H--PSDNKIIRR-YKMI-FIPPGFWPRLIIRLLSFPKKA--IK---
AqueK495_Aque   ---------------M-TKDEVVSRK-ILFR-YLPCCFFSHFVSRVLSYIDQAGAQLA--
AqueK496_Aque   ------VTFTA-GVEL-NYLPPIRRI-WFSN-YIPDGFWPRLICRLLNDQLIKSILS---
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   -------------ENT-VYLPPLRHT-YLLA-FVPSGFWPRLMSRVLSDPSIMRLAQ---


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ----FEN--KKNTK---------------------------------------SRNRKVT
CG5483_Dmel     ---GV-----YMAS----------------------------------------QDYA-D
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ----FEN--KKNTK---------------------------------------SRNRKVT
T27C10.5_Cele   ---SI-----FMTT---------------------------------------SADRA-K
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ---------KKISS---------------------------------------AGNER-N
LRRKc_Spur      ---------KKISP---------------------------------------ARNER-K
LRRKb_Spur      ---GE----EDHAE-----------------------------------TIPI---WHMP
LRRKa_Spur      ---SM----YL-LS----------------------------------------------
AqueK485_Aque   ---GD-----TLLT---------------------------------------PSSPS-S
AqueK486_Aque   ---VLADY-NNETE---------------------------------------STADEDT
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ---SV----DDCLQ----------------------------------------------
AqueK489_Aque   ---------EDKM----------------------------G---------------E--
AqueK490_Aque   LLNLLKVMQEDPVRNHQPRKPLNLHLDIGKEETSLMYSPTED---------------E--
AqueK491_Aque   ---ALGFS-EKEI----------------------------E---------------E--
AqueK492_Aque   ---VLADH-SNETD---------------------------------------STPDEDT
AqueK493_Aque   ---VLADY-NNETH---------------------------------------STADEDT
AqueK494_Aque   ---HA-------------------------------------------------------
AqueK495_Aque   ---VMAH--PSNPP---------------------------GPAEEKRKRSSSFRNTN-K
AqueK496_Aque   ---NY-----YDSV----------------------------------------EN----
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ----------VGCG---------------------------------------LTD----


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      IY----------------------S-FT---------------------------G----
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      IY----------------------S-FT---------------------------G----
T27C10.5_Cele   I-----------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      LG----------------------S-SKR---LTDDE--------------MFPFQ----
LRRKc_Spur      IC----------------------R-SK---------------------------S----
LRRKb_Spur      VL----------------------N-TQ---------------------------G----
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   L-----------------------------------------------------------
AqueK486_Aque   IPGIPPAPNVTDETSAQMISSPVLS-PS---------------------------SNQFL
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   IPGVPPMPNVTDEMSAQMISSPVLS-PS---------------------------SNQFL
AqueK493_Aque   IPGVPPVTNVTNETSAQVISSPVLS-PS---------------------------SNQFL
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   -Y----------------------KLSRRSYIISEDSEDGGADASKAISISVTT-M----
AqueK496_Aque   --------------------------S---------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ---------NQ----------------R--------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ---------SQ----------------R--------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ---------RK----------------S--------------------------------
LRRKc_Spur      ---------AK----------------S--------------------------------
LRRKb_Spur      ---------SA---V--------S--TH--------------------------------
LRRKa_Spur      ---------DD---V--------H--RFF----------------------E--------
AqueK485_Aque   -----------------------------P------------------------------
AqueK486_Aque   LPNINRFIVDDD------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ---------AS---L--------Q--GH--------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ---------------------------KIPGGEPSSHVPVKGRGTTAKKQRSFSDSGDTE
AqueK491_Aque   ---------------------------TV----------------------R--------
AqueK492_Aque   LPNINCFIVDED---------------D--------------------------------
AqueK493_Aque   LPNINCFIIDDD------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ---------DRQAQCGDAIRSRLDSVSK--------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ---------------------------------------RA-------------------
LRRK1_Hsap      ---------------------NR--CS---------T-FRV-------------------
CG5483_Dmel     ---------------------FD--LR---------T-SLE-------------------
LRRK2_Mmus      ---------------------------------------RA-------------------
LRRK1_Mmus      ---------------------NR--CS---------T-FRV-------------------
T27C10.5_Cele   ---------------------AD--IA-----------TKH-------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ---------------------SI--SE---------A-ISF-------------------
LRRKc_Spur      ---------------------SI--SK---------G-IRF-------------------
LRRKb_Spur      ---------------------RQ--FR---------M-RSH-------------------
LRRKa_Spur      ---------------------GE--PL---------S-EFTNEFQWVCWQSGIELKFMSV
AqueK485_Aque   ---------------------PR-PAN---------PLVTP-------------------
AqueK486_Aque   ----------------------D--AK---------P-LKP-------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ---------------------GA--LY---------N-IGT-------------------
AqueK489_Aque   ---------------------QL--LE---------S-FHN-------------------
AqueK490_Aque   LQVHATNDAGTIEDSTVSTVSKR--IS--------SDPIS--------------------
AqueK491_Aque   ---------------------IM--IS--------GDLSTL-------------------
AqueK492_Aque   ---------------------ED--PK---------P-LKP-------------------
AqueK493_Aque   ----------------------N--TE---------P-FKP-------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ---------------------SLPRREQFSTNEDSWT-TMY-------------------
AqueK496_Aque   ------------------------------------D-ESV-------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   --------------------------------------EEC-------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      TVFHVKAVVREKLLSSVFERERRPESVHVLSLTDDPDHFPRNVSLSRSGQLEILIPNQTL
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      EVTHRIQQREANGKGMSDSVKILTSLETVSRLLATIIDLIDTLIENFYPNLCEPLGTTFE
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      GELFITRVVPCHRCWRDYNKPSWDEVDVSEWEFIHALDAEEHMNAEHESPLLWSSISSAD
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      AQMITTRTGEQSKLCCGLSCSYPRLHDDILTGVNLKQLNPRRRAAHALQRKDRIAATTNA
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      RLSADGDMTLQTEIDNDREHPLPLETCSELGIEPDVSNDMMPMDTVLNSTLLSSIHKSAD
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      VPHDICVYGFLFEELVLQSMRNEFVECPNHGNIAISVVAPDVVSVMLVRDLHRKFEDSSV
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      KEFIVSLLNKFEVAVTYDPKHLLIPSRLPQEGVDTTIIPVFRSRSDSTRVYRKTGARSPS
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      PIQSSPPERWNRKAVRGHSPSPSRIYCHDGSPTDGSSTRETSPETVETPERSPATMSIPV
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      PIRRNLQGKARMANCASSPPCEMYSEASTSAMGLDAMDTPTFELLRKSATITKSPSSGDV
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      NTGTVKGKLDRADIELVSNKAKDDKVPSPFDGYKFTPVENLKTAIRRLYILQYIPSGFWS
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ---------------------------------------LRPNRMYWRQGIYLNWS-P-E
LRRK1_Hsap      ---------------------------------------KRNQTIYWQEGLLVTFD-G-G
CG5483_Dmel     ---------------------------------------QDTQWNLWQTGLALYYG-P-I
LRRK2_Mmus      ---------------------------------------LRPNRMYWRQGIYLNWS-P-E
LRRK1_Mmus      ---------------------------------------RRNQTIYWQEGLLVTFD-G-G
T27C10.5_Cele   ---------------------------------------AKAEWVVWQTGIELHVK-G-H
GbpC_Ddis       ----------------------------------------------QKRAVILRNQ-DNH
Pats1_Ddis      ------------------------------------------AKCYWKNGMILQHD-EE-
QkgA_Ddis       ------------------------------------------IKTYWKDGVLLDIL-TP-
QkgA_C2d_Ddis   ------------------------------------------IKTYWKDGVLLDIL-TP-
Roco10_Ddis     -------------------------------------------YKCWKDLAILVPEIA--
Roco11_Ddis     ------------------------------------------IKTYWANGILLDIL-TT-
Roco4_Ddis      ------------------------------------------VRTYWRNGVLLDIL-TP-
Roco5_Ddis      -------------------------------------------KEFWKNGLLVEKD-D--
Roco6_Ddis      ------------------------------------------PILYWRNGVVVESQ-SG-
Roco7_Ddis      -------------------------------------------LCIWQNGMVLQPA-GQ-
Roco8_Ddis      ------------------------------------------PIVYWSTGILFRKT-QT-
Roco9_Ddis      ------------------------------------------IKHCWKNGVILENC-YL-
LRRKd_Spur      ---------------------------------------HQTESIYWREGIFFRHN-T-G
LRRKc_Spur      ---------------------------------------LQTESIYWREGIFFRHK-T-G
LRRKb_Spur      ---------------------------------------EEPETVFWREGIYVCWS-E-E
LRRKa_Spur      HLISRLLSDQMIPGLINSMYLLSDDVHRFFQGEPLSEFTNEFQWVCWQSGIELKFM-S-V
AqueK485_Aque   ---------------------------------------TGARLFLWQKHFVFEDI-D-G
AqueK486_Aque   ---------------------------------------EDIELLYWKNGIVYKGP-D-L
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ---------------------------------------TNVRWRYWKTGLVFDVD-H-Q
AqueK489_Aque   ---------------------------------------NAVNWNYWASGIIVWIN-A-T
AqueK490_Aque   ---------------------------------------ICQGIIVWRTGIQLKTG-SGV
AqueK491_Aque   ---------------------------------------VELEWSYWTTGVEFWYK-G-Y
AqueK492_Aque   ---------------------------------------KDIELLYWKSGIVYKGP-D-L
AqueK493_Aque   ---------------------------------------KDIELLYWKSGIVYKDP-D-L
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ---------------------------------------MFSRALIWKDGFHLEFL-D-G
AqueK496_Aque   ---------------------------------------VKSDWTCWKSGLVYVSR-G-R
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ---------------------------------------RLLKWTKWRTGMILRFG-N-V


LRRK2_Hsap      -A-YC---------------L---------------------------------------
LRRK1_Hsap      -Y-LSVES----------SDVN--------------------------------------
CG5483_Dmel     -L-IFKIW-----------EVP-FQK----------------------------------
LRRK2_Mmus      -A-YC---------------L---------------------------------------
LRRK1_Mmus      -Y-LSVES----------SDVN--------------------------------------
T27C10.5_Cele   -S-LFTLK-----------QFLPLAE----------------------------------
GbpC_Ddis       -E-ALIEL----------K-----------------------------------------
Pats1_Ddis      -T-IFL------------------------------------------------------
QkgA_Ddis       -SDK----IKQQQLLQKKSIFE--------------------------------------
QkgA_C2d_Ddis   -SDK----IKQQQLLQKKSIFE--------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     -EDIKIQ-----KLNHKKHSIL--------------------------------------
Roco4_Ddis      -EQVKLQQSKQQQLQQQQQ-QQ--------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      -K-SFLST----------S-----------------------------------------
Roco7_Ddis      -L-WGGAA----------K-----------------------------------------
Roco8_Ddis      -Y-RENIK----------D-----------------------------------------
Roco9_Ddis      -S-FPVARRFP-MSPNAKN-----------------------------------------
LRRKd_Spur      -Q-ILVRS----------M-VF--------------------------------------
LRRKc_Spur      -Q-ILVRS----------T-VF--------------------------------------
LRRKb_Spur      -A-FFLIE-----------PLK-KG-----------------------------------
LRRKa_Spur      -T-VFHVK-----------AVV-REK----------------------------------
AqueK485_Aque   SK-LWLVV-----------Y----------------------------------------
AqueK486_Aque   -S-FGV-E-----------SF---------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   -L-LLSIN-----------SLK-MDE----------------------------------
AqueK489_Aque   -S-LVYSI----------ESIN--------------------------------------
AqueK490_Aque   -Q-LTIHS----------Q-----------------------------------------
AqueK491_Aque   -S-LLR-V----------AEIR--------------------------------------
AqueK492_Aque   -S-FGV-E-----------SL---------------------------------------
AqueK493_Aque   -S-FGV-E-----------SL---------------------------------------
AqueK494_Aque   ---YFMIE-----------QLE-SS-----------------------------------
AqueK495_Aque   -T-LCWAE-----------F----------------------------------------
AqueK496_Aque   -T-LLLVR-----------HIP-NPP----------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   -T-LLSM-----------EELS-GKLFTGNGTKMAIMKDGGRWEEHPLDTTVYGVNVEVP


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ---------------------------------------------T-ERTQ---------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ---------------------------------------------V-RDID---------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------PTTTLSPFLCSLSLTDSQ
QkgA_C2d_Ddis   ------------------------------------------PTTTLSPFLCSLSLTDSQ
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------P-----------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ---------------------------------------------LL-------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ---------------------------------------------FI-------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------PEGTFSDCLP--------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   --------------------------------------------TSW-------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   DVFPLLRYAELNPNRIRIVQRSGSTGQQEEEGEEQEEERVRRPRQHLGD-----------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ----------------------------------------------PFR--TDGNRFKLK
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   -----------------------------------------------YS----AIDMRAK
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       NYSPLEPPPLILNSPRVNRKFISNSTSTTSTTTSTTS-----------------------
QkgA_C2d_Ddis   NYSPLEPPPLILNSPRVNRKFISNSTSTTSTTTSTTS-----------------------
Roco10_Ddis     ---------------------------SMSTTSSSSS-----------------------
Roco11_Ddis     ----------------------NNSSSTSSSTSSSTS-----------------------
Roco4_Ddis      ---------------------NNNESNDSSVNNNNNN-----------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      -------------------------------------SSVFERERRPESVHV--------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   -------------------------------------DPM------QRA--V--------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ---------------------------------SSAQ-----------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   -------------------------------------GPT------PES--S------LK
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ---------------------ITEDPRERSFSDSMRTPPTQ-----PPA--A------SG


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     Q-DGIWSDVN--------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   DEQKRWRTWN--------------Q-----------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------TSTTSSNNITPLSMSSITPYSPTSPRTPSF
QkgA_C2d_Ddis   ------------------------------TSTTSSNNITPLSMSSITPYSPTSPRTPSF
Roco10_Ddis     ------------------------------------------------------SSTANS
Roco11_Ddis     ------------------------------SSTSSSSS----------------SSTS-S
Roco4_Ddis      ------------------------------NNNNNNNNI---------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ---------LSL--T-------DD--PD--------------------------------
AqueK485_Aque   ---------E--------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ---------ISATYDKMKRFHFADSNGD--------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------G-----------------SSYSRTPSIPF-
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   AVNSKWRIEI--------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   SRNKRWTISE--------------KVGSIARKVRSYTNIAD------------------I


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ---------------------SSSSTTTSSSS----SSSSPSS-QFCGVGCHR-------
QkgA_C2d_Ddis   ---------------------SSSSTTTSSSS----SSSSPSS-QFCGVGCHR-------
Roco10_Ddis     ---------------------TTTTSATTLQS-----LASGS------------------
Roco11_Ddis     ---------------------SSTSTTTTTVQIQSSPFGNSTTIVNKLTNIDN-------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ----HFPRNVS---LSRSGQL-----------------------EILIP-----------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ----VLP---V---LGSTEVI-----------------------EVVVK-----------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   --------------------------------------------HIYVP-----------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   NDSLTLP---PTSSVSQSPRVA--------------------SGFVVLPDHHSNSSSSDS


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ----------------------NIN--KNNGSSNELIKTLTKINNQNGSSGELIKTTTTT
QkgA_C2d_Ddis   ----------------------NIN--KNNGSSNELIKTLTKINNQNGSSGELIKTTTTT
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ----------------------NNNNNNNNNNNNN---NNNNINNNNNNNNNNNNNNNNN
Roco4_Ddis      -----------------------------------------------------INSSSSS
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   EDEKKDKEEEEGESTGGIGRVRGVL--R--------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       STST-STTSTTTPTTTT-PTIPIKNNNN---------------------------KKLP-
QkgA_C2d_Ddis   STST-STTSTTTPTTTT-PTIPIKNNNN---------------------------KKLP-
Roco10_Ddis     ------------------------SNN-------------------------T-------
Roco11_Ddis     N-----------NNNNNNNNNNNNNNNNIKNIINNFENQNNLNNIITNNFGGKFE--IIK
Roco4_Ddis      SLNLTQTSTSTSPSKLSLNNSQ-INNSN-----------------------STLNSQQL-
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   --------------------EPLEDCED---------------------------LSFQ-
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      -----------------------VGSEVL-------------------------DN--H-
LRRK1_Hsap      ------------------------------------------------------WK-KK-
CG5483_Dmel     ---------LSSSSILEVYF-P-LYEVNI--------------S----------QEV---
LRRK2_Mmus      -----------------------VGSEVL-------------------------DN--R-
LRRK1_Mmus      ------------------------------------------------------WK-KK-
T27C10.5_Cele   ---------PSHRPIVEMV----VNSLSI--------------S----------AA----
GbpC_Ddis       ---------------------T--IK----------------------------DNKDGT
Pats1_Ddis      -------------------------------------------------------EMNN-
QkgA_Ddis       INRTVSSLCLTAKPKLQALI-TFIKKKSF--------------E----------QSHDN-
QkgA_C2d_Ddis   INRTVSSLCLTAKPKLQALI-TFIKKKSF--------------E----------QSHDN-
Roco10_Ddis     -----------------LQQ-QFREERIL-------------------------VNVDH-
Roco11_Ddis     KNDFESPLS-SKKPKHQVLV-TFKNQKSF--------------E-----------SKDK-
Roco4_Ddis      INPSVSPLS-STTPRHQALI-TFIKKKSF--------------E-----------SKDK-
Roco5_Ddis      -------------------------SQCL-------------------------IESIQ-
Roco6_Ddis      ---------------------TA-LIEMV-------------------------PSYAN-
Roco7_Ddis      ---------------------SF-DSQCL-------------------------IEYDS-
Roco8_Ddis      ---------------------SMSSCGTL-------------------------VEFDT-
Roco9_Ddis      ---------------------PFRRSST--------------------------ISVLE-
LRRKd_Spur      ------------------------------------------------------PS-TD-
LRRKc_Spur      ------------------------------------------------------PS-TD-
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ---------------------------------------NQTLEVTHRIQQREANG-KG-
AqueK485_Aque   --------------GGQLG----PEST----------------------------Q----
AqueK486_Aque   -----------------------RKSKVL-------------------------AR--I-
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ---------------------S--SD----------------------------LGL---
AqueK491_Aque   LNGQWLA-------------------------------------------------VDET
AqueK492_Aque   -----------------------RKSKVL-------------------------AG--T-
AqueK493_Aque   -----------------------RKSKVL-------------------------AH--T-
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   --------------EMISVLQEIRSRV-E-------------------------CF-DQ-
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------KEEIQTQFEELKKKRAHGHHPGAIWNND-------------FNT-MS-


LRRK2_Hsap      PESFLKIT--V---PS------------------------------------CRKGCILL
LRRK1_Hsap      KSGGMKIV--C---QS------------------------------------EVRDFSAM
CG5483_Dmel     DDNERQLLAEI---RPH-----------------------------------MSQVAKLL
LRRK2_Mmus      PESFLKIT--V---PS------------------------------------CRKGCILL
LRRK1_Mmus      KSGGIKII--C---QS------------------------------------EMRDFSAM
T27C10.5_Cele   SQHGRKLS--M---KTD-----------------------------------VEGRSRLL
GbpC_Ddis       FKKILTVD--V---RG------------------------------------LVSPVSLL
Pats1_Ddis      AKKSLSFT--V---RG------------------------------------GANSTTLS
QkgA_Ddis       DSYKLNIQ--V---RTYNT---------------------------TI--DKEHSVSLFF
QkgA_C2d_Ddis   DSYKLNIQ--V---RTYNT---------------------------TI--DKEHSVSLFF
Roco10_Ddis     DSNTIEIT--I---R-------------------------------------FIRPSTLS
Roco11_Ddis     DTYKLNVE--I---RSFNV---------------------------SNNNDKDFLASLFF
Roco4_Ddis      DSYKLNIE--V---RSFNT---------------------------TI--EKDHSASLFF
Roco5_Ddis      QFNQINFK--A---W-------------------------------------GKNPASLL
Roco6_Ddis      CSSTIKIS--V---RGD-------------------------------RRTGRGLSAKLL
Roco7_Ddis      VNFILKVS--I---RD------------------------------------DNKQQQLL
Roco8_Ddis      VTQQLQIR--V---RGH--------------------------------E--FDACAKLF
Roco9_Ddis      ADDLVSIQ--V---LGD--------------------------------TKIEISSSKMC
LRRKd_Spur      KSPGVDIL--I---SC------------------------------------QEGHFSAM
LRRKc_Spur      KSPGVDIL--I---SC------------------------------------QEGHFSAM
LRRKb_Spur      -ADTLKIT--V---PK------------------------------------TKQGYRLL
LRRKa_Spur      MSDSVKIL------TS------------------------------------LETVSRLL
AqueK485_Aque   YCGRIDVLLK----TAT-----------------------------------REKEAVLL
AqueK486_Aque   NGDSIVIL--A---SP------------------------------------NSKGTKLI
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ---DIELS--CNAGYD------------------------------------RAVGPKLL
AqueK489_Aque   -NFSLIIS--V---------------------------------------ANTPLGIRAM
AqueK490_Aque   EETGVEVC--C---TE------------------------------------DEEGIAAM
AqueK491_Aque   PNTGLEVL--V---PDYICPSVIEKVLPSLVNIDEGAEDEFDQEPFP-TREHSWMSAQLL
AqueK492_Aque   NRDGIVIL--A---SP------------------------------------NSKGTKLI
AqueK493_Aque   NRDGIVIL--A---SP------------------------------------NSKGRKLI
AqueK494_Aque   -KNEFDIT--V---PN------------------------------------TTLGIRLL
AqueK495_Aque   FNESVSII--C---KGD-----------------------------------EKAKVKLL
AqueK496_Aque   LEETDKLQ--A---PYK----------------------------------VAGQATQLM
AqueK497_Aque   ---------------S------------------------------------NNDDFSAI
AqueK498_Aque   SNGPPKLT--E---ENN-----------------------------------DRMRAGLL


LRRK2_Hsap      GQVVDHIDSLMEEWFPGLLEIDICG-E-GETLLKKWALY-----------------S---
LRRK1_Hsap      AFITDHVNSLIDQWFPALTATES---D-GTPLMEQYVPC-----------------PVC-
CG5483_Dmel     ALTVDHIDLLLEDWYPSLGTRFVHTSE-GRFLITRLVLC-----------------PRC-
LRRK2_Mmus      GRVVDHIDSLMEEWFPGLLEIDICG-E-GETLLKKWALY-----------------S---
LRRK1_Mmus      AFITDHVNSLIDQWFPALTATES---D-GTPLMEQYVPC-----------------PVC-
T27C10.5_Cele   AMISDLLDTLLEDWYPALGTRFVHSSE-GDLLVSRYVLC-----------------PQC-
GbpC_Ddis       RIVTDTIESLFSQWYK-L-------------DIKRYISC-----------------YEC-
Pats1_Ddis      RDVIETIQSLLDDSFQ-L-------------PTYVFVPC-----------------FHC-
QkgA_Ddis       QQLLFTIDTLISGSYQGL-------------EVTRTIPC-----------------THC-
QkgA_C2d_Ddis   QQLLFTIDTLISGSYQGL-------------EVTRTIPC-----------------THC-
Roco10_Ddis     SQVYSIFESLVSKWYK-V-------------SFKTFIPC-----------------SHC-
Roco11_Ddis     QQLLSTIDTLLSGSYGGL-------------KVTRLIPC-----------------IHC-
Roco4_Ddis      QQILFTIDTLLASSYVGL-------------EITRMIPC-----------------IHC-
Roco5_Ddis      RFIIETAEVLISGWYK-L-------------HFHFLVPC-----------------N-C-
Roco6_Ddis      RLIVEIADTLCTSWYH-L-------------ETNQVIPC-----------------PHC-
Roco7_Ddis      KSIVDLVSSFILWYFPGR-------------LSNVRVAC-----------------THC-
Roco8_Ddis      QIVLENVDTILKDYQ-IN-------------QSQTYIPC-----------------SC--
Roco9_Ddis      RHILQIFESILESYN-QL-------------AYTIYISC-----------------IHC-
LRRKd_Spur      GCVVDQIEGLIKDWYPGLCTSIHE--S-IQPKVQRLVPC-----------------PIC-
LRRKc_Spur      GCVVDQIEGLIKDWYPGLCASIYD--S-LQPKVQRLVPC-----------------PIC-
LRRKb_Spur      GLVSDHLDDLIEEWFPGLCELDPR--L-GRPLVQRLVPC-----------------VMC-
LRRKa_Spur      ATIIDLIDTLIENFYPNLCEPLGTTFE-GELFITRVVPC-----------------HRC-
AqueK485_Aque   RIVTEEIDQLLMEKYPSLLDDYLTPS-----LVDVLVPL-----------------SSS-
AqueK486_Aque   CQLVDIILSLIHEWYPGLEENNVNS---G---VEQRVPC-----------------YEC-
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   SKALEMIDEVLKGHYEKLAENGIY-TV-G--EMLHIVPC-----------------PLC-
AqueK489_Aque   NLLSFTINTLIMNWYPQLWDTVSIN-----------GIC-----------------SVC-
AqueK490_Aque   AKVCWLIQRIFEQRYPEFSPKIQPS---SQNGLTQIILC-----------------PQC-
AqueK491_Aque   SQTVEQIDTLLEDWFPGIGSKDGGRGMYSVPYVNRVVPC-----------------PYC-
AqueK492_Aque   CQLVDIILNLIYEWYPGLEENSVNS---G---VEQRVPC-----------------YEC-
AqueK493_Aque   CQLVDIILNLIHEWYPGLEENNVNS---G---VEQKVPC-----------------YEC-
AqueK494_Aque   CSVVDNVETLIDEWFPGLRSISIT--S-GDALVSPSALC-----------------PLC-
AqueK495_Aque   AFLLSCVQDICTEWYINLHR-------------VHYSPC-----------------YSC-
AqueK496_Aque   VAISNHI-SFLSSWFQGMLEQNE---R----GHVDYVPC-----------------WKC-
AqueK497_Aque   GYVVDQLDSLIDEWFPGLNDLDL---D-GEWLVERQALWITPPELKESISAEPGTESECF
AqueK498_Aque   SKVVDHITLLVEDWFTGVRPR------------FLVVPC-----------------PHC-


LRRK2_Hsap      ----F-------------------------------------------------------
LRRK1_Hsap      --E-T-------------------------------------------------------
CG5483_Dmel     --L-W-------------------------------------------------------
LRRK2_Mmus      ----F-------------------------------------------------------
LRRK1_Mmus      --E-A-------------------------------------------------------
T27C10.5_Cele   --V-R-------------------------------------------------------
GbpC_Ddis       --A-I-------------------------------------------------------
Pats1_Ddis      --I-F-------------------------------------------------------
QkgA_Ddis       --I-Q-------------------------------------------------------
QkgA_C2d_Ddis   --I-Q-------------------------------------------------------
Roco10_Ddis     --I-E-------------------------------------------------------
Roco11_Ddis     --I-E-------------------------------------------------------
Roco4_Ddis      --V-Q-------------------------------------------------------
Roco5_Ddis      --I-NCNSILISNIGSINIINSTINLSSNNNNNVNIVNSQQQQQQQQQQSPSTSTSSSSS
Roco6_Ddis      --I-N-------------------------------------------------------
Roco7_Ddis      --T-N-------------------------------------------------------
Roco8_Ddis      --S-C-------------------------------------------------------
Roco9_Ddis      --I-E-------------------------------------------------------
LRRKd_Spur      --V-I-------------------------------------------------------
LRRKc_Spur      --V-I-------------------------------------------------------
LRRKb_Spur      --E-G-------------------------------------------------------
LRRKa_Spur      --W-R-------------------------------------------------------
AqueK485_Aque   --W-F-------------------------------------------------------
AqueK486_Aque   --R-K-------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   --F-G-------------------------------------------------------
AqueK489_Aque   --Y-S-------------------------------------------------------
AqueK490_Aque   --S-K-------------------------------------------------------
AqueK491_Aque   --V-G-------------------------------------------------------
AqueK492_Aque   --R-K-------------------------------------------------------
AqueK493_Aque   --H-K-------------------------------------------------------
AqueK494_Aque   --P-A-------------------------------------------------------
AqueK495_Aque   --L-K-------------------------------------------------------
AqueK496_Aque   --Y-G-------------------------------------------------------
AqueK497_Aque   YDPLN-------------------------------------------------------
AqueK498_Aque   --S-H-------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      LTSSQPSLSTPLTSSQPSLSTSQPQLSTTTTTTATTTTSSSSQSLASQQSSSQIQLTHSS
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      SLSSMSGSISTNSLNSNVSSSSSTPSLLSPPLLNPDSTSSSNETSGDILDLDFADYYDGE
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      SVSPGGTLKGKRKKNPSKFLTLYRNTNKPKINGTTGSGSSSSIVTTAVSSSSSSSSSTSL
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      --------------------------ND-G------------------------------
LRRK1_Hsap      --------------------------AWAQHT---DPSE---------------------
CG5483_Dmel     --------------------------KLQLQQN-NEPSDREVPPVGCNRPSRSSRRGAGA
LRRK2_Mmus      --------------------------ND-G------------------------------
LRRK1_Mmus      --------------------------SWAQHA---DPNE---------------------
T27C10.5_Cele   --------------------------DAERNG---SRSRTS-SSASHR------------
GbpC_Ddis       --------------------------LY-D------------------------------
Pats1_Ddis      --------------------------LS-L------------------------------
QkgA_Ddis       --------------------------LNPT------------------------------
QkgA_C2d_Ddis   --------------------------LNPT------------------------------
Roco10_Ddis     --------------------------KK-I------------------------------
Roco11_Ddis     --------------------------KDPH------------------------------
Roco4_Ddis      --------------------------KNPR------------------------------
Roco5_Ddis      SNTSSRQLDLSKISHLINQQLSFGPSKT-Q------------------------------
Roco6_Ddis      --------------------------KP--------------------------------
Roco7_Ddis      --------------------------QH-I------------------------------
Roco8_Ddis      --------------------------EC-R------------------------------
Roco9_Ddis      --------------------------TLPK------------------------------
LRRKd_Spur      --------------------------HGPDDF---EPVT---------------------
LRRKc_Spur      --------------------------HGPDDL---EPVT---------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      --------------------------DYNK------PSW-D-E-----------------
AqueK485_Aque   --------------------------TTDLLSPSSSPDS-----------------LHEA
AqueK486_Aque   --------------------------LG-R------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   --------------------------EIDT-R---SPKS-D-H-----------------
AqueK489_Aque   --------------------------NDE-------------------------------
AqueK490_Aque   --------------------------S-PL------------------------------
AqueK491_Aque   --------------------------GAEV-----TP-----------------------
AqueK492_Aque   --------------------------LG-R------------------------------
AqueK493_Aque   --------------------------LG-C------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   --------------------------NDP--------EK-A-P-----------------
AqueK496_Aque   --------------------------GLEWIG---NPPS-D-T-----------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   --------------------------GLTGPT---QGSDRI-PFL-------------RS


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     YFLHGVGDPGE--------------DGAL-------NVFSA-YLN----A----------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ---R----SQD--------------DGEL-------PI----------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------VD-VSEWEFIHALDAEEHMNAEHESPLLWSSISSADAQ----------
AqueK485_Aque   FSIGGRGGRDEDEEGVAIPNLSYSLKGRG-------HSFSS-IVD----STSLQSFSSIQ
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------KR----FA-------------N--------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ----------ND---------------------------VFTS-MSHGPE----------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------LLI---------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   FSINPQVRPPNDLVDSS-F-------------YPYSAPTQAH-IA---------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     -TARRE---RRSEDSLGAGSDADSG----------------V---GPDS----------A
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------T----------S
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      -MITTR---TGERSKLCCGLSC--SYPRLHDDILTGVNLKQLNPRRRAAHALQRKDRIAA
AqueK485_Aque   GTLHEAFASIRATGTLPSSVSSE-E----------------VPNFDPGS----------I
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   -------------------------HPKL-------------------------AQRIRT
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ----TL---TGTPSVISMNTKE--DAATPSSTVTLLDNTNSIDTNSVSTTGGVASRARRD
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   -----------------------------------------------------------S


LRRK2_Hsap      -------------------------------------------E----------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     GSSRNTSV--DGH-----------------------------------------------
LRRK2_Mmus      -------------------------------------------E----------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   SSHM-KGS---RT-----------------------------------------------
GbpC_Ddis       -------------------------------------------R----------------
Pats1_Ddis      -------------------------------------------P----------------
QkgA_Ddis       -------------------------------------------I----------------
QkgA_C2d_Ddis   -------------------------------------------I----------------
Roco10_Ddis     -------------------------------------------V----------------
Roco11_Ddis     -------------------------------------------S----------------
Roco4_Ddis      -------------------------------------------A----------------
Roco5_Ddis      -------------------------------------------D----------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      -------------------------------------------E----------------
Roco8_Ddis      -------------------------------------------D----------------
Roco9_Ddis      -------------------------------------------S----------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      TTNARLSAD-------GDMTLQTEIDNDREHPLPLETCSELGIEPDVSNDMMPMDTVLNS
AqueK485_Aque   RSNPQSSL--GGR-----------------------------------------------
AqueK486_Aque   -------------------------------------------E----------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   SSVSRSSTG-------RQ------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   -------------------------------------------G----------------
AqueK491_Aque   LMPSLQKTTASGSPHSRRRYTSDNIDDTSIETSPAATGVGLMQA----------------
AqueK492_Aque   -------------------------------------------E----------------
AqueK493_Aque   -------------------------------------------E----------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   TIASQSSVPQQRSRWGW--------------------------GRGQG--ASP-------


LRRK2_Hsap      ----------------EHQKILLDDLMKKAEEG-DLL-VNPDQ-----------PRLTIP
LRRK1_Hsap      ------------K-SEDVQYFDMEDCVLTAIE-RDF-ISCPRHPD-----------LPVP
CG5483_Dmel     ---PGYH--LPDN-SNVCYAWMIEECILSVYN-QSK-ISCPVHL-------------EQS
LRRK2_Mmus      ----------------EHQKILLDELMKKAEEG-DLL-INPDQ-----------PRLTIP
LRRK1_Mmus      ------------R-SESVQYFDMEDCVLTAIE-RDF-ISCPRHPD-----------LPVP
T27C10.5_Cele   ---TGDI--SKCR-GGVVHCFVIEECMLAGRE-YNW-VECPSHG-------------GLH
GbpC_Ddis       ----------------NPTLFTIEECELAVIDGKTVL-TCNQKSDSDR----VSTSHRLK
Pats1_Ddis      ----------------QCYYFPLDVCENAAVKGTGYL-KCLTY-D-----------ANVR
QkgA_Ddis       ----------------EPYHFDLGDCISALEDGRSHV-YCGNDPN-----------TPVR
QkgA_C2d_Ddis   ----------------EPYHFDLGDCISALEDGRSHV-YCGNDPN-----------TPVR
Roco10_Ddis     ----------------TPHLFKLEECEAQIFKGELGI-YCQYKPNNNNS--SNDTSSPIA
Roco11_Ddis     ----------------EPHLFDINSCISQLLLGKSQL-VCGKDST-----------TPVR
Roco4_Ddis      ----------------DPYYFDFSSCISALQDGKPHL-FCRNDPS-----------IPVR
Roco5_Ddis      ----------------LRTMFLYEEIERIFLSKKFEV-VCRSSIT--------GEETIVR
Roco6_Ddis      ----------------NCTLFSLSDCEAVASSGVWYL-LCGD--------------RKIN
Roco7_Ddis      ----------------NPTMYTLDYLENQASLGQTNV-ICKAQLGGIIHETLSPRTTKID
Roco8_Ddis      ----------------LPHLFPIDLIEETFGKGESHT-KCPITMK------------LVS
Roco9_Ddis      ----------------EQYLFSLNQIEESVIKGKTYQ-SCPIHSS-----------IPIK
LRRKd_Spur      --------------EDLPHCYTVEELAQTYVRGETHITACANSKE-----------KPIT
LRRKc_Spur      --------------ENLPHCYTVEELAQKLARGETHITACANSKE-----------KLIP
LRRKb_Spur      ----------------RPHLHDLSELLEQSET-SDT-ITCPNHPT-----------RKVP
LRRKa_Spur      TLLSSIHKSADVPHDICVYGFLFEELVLQSMR-NEF-VECPNHG-------------NIA
AqueK485_Aque   ---Q-VI--DETQ-TQIQYLVPAWECLQESFK-SPA--QQLRSG-------------KLD
AqueK486_Aque   ----------------KPFEFKIDQYMSIITSSRPQI-ECGYERDA-------ARNHKVS
AqueK487_Aque   --------------------------------------EYVEH-------------GSIP
AqueK488_Aque   ---KSIH--QRLG-EDVLIVFSIDQCIRSSMN-VEY-IECPKHG-------------DIQ
AqueK489_Aque   ----------------SLSLFPINDCFNSLTN-ARTL-SCPKDHE-------------LS
AqueK490_Aque   ----------------GATNFIIETCFVSLKEQESFTHNCHHH-D-----------DPIP
AqueK491_Aque   ----------------SKFGFMIETCVAASRG-LATL-ECPTHPL-----------QPLD
AqueK492_Aque   ----------------KPFEFKIDQYMSIITSSRPQI-ECGYERDA-------ARNHKVS
AqueK493_Aque   ----------------KPFEFKIDQYMPIIISSRTQI-ECGYERDA-------ARNHKVS
AqueK494_Aque   ---------------FSIHAFPMRELQLISLK-QDE-IMCPIHKD------------TVP
AqueK495_Aque   ------------------FYFNLSQISM--AT-DQV-LTCEKCQ------------AVSP
AqueK496_Aque   ----------DVE-GSFCVCLPFANCIIPSSH-NDD-LSCPVHG-------------ALK
AqueK497_Aque   ---------------QEVFIFKLEDCALKALQ-QDT-VYCADYDV------------HVP
AqueK498_Aque   --VPA-P--TPTP-NVVFYAFQYEECVVRARD-VPY-VKCPVHGE-------------LP


LRRK2_Hsap      ISQIAPDLILAD------------------------------------------------
LRRK1_Hsap      LQELVPELFMTD------------------------------------------------
CG5483_Dmel     MAQLAPDVIFAD------------------------------------------------
LRRK2_Mmus      ISQIAPDLILAD------------------------------------------------
LRRK1_Mmus      LQELVPELFMTD------------------------------------------------
T27C10.5_Cele   MRELAPDTVFAD------------------------------------------------
GbpC_Ddis       LDILAPDISMVD------------------------------------------------
Pats1_Ddis      TDLLVPDLVMSN------------------------------------------------
QkgA_Ddis       IDYIAPDICLKK------------------------------------------------
QkgA_C2d_Ddis   IDYIAPDICLKK------------------------------------------------
Roco10_Ddis     SSRSNPKISRKDSKNLIQSNNNDNNNSLSKKDLKELAKQNKEKEKEKEKDKDKEKEKERK
Roco11_Ddis     IDYIAPDLSIKK------------------------------------------------
Roco4_Ddis      IDYIAPDLCLKK------------------------------------------------
Roco5_Ddis      LDSLVPELMMSD------------------------------------------------
Roco6_Ddis      FETFVPDVAMSD------------------------------------------------
Roco7_Ddis      IYSLAFEVTFNS------------------------------------------------
Roco8_Ddis      LCKISPDITLSS------------------------------------------------
Roco9_Ddis      LNQLAPDLTMND------------------------------------------------
LRRKd_Spur      ISVLIPDMFMKD------------------------------------------------
LRRKc_Spur      ISVLIPDMFMKD------------------------------------------------
LRRKb_Spur      LQILAPDVTLAD------------------------------------------------
LRRKa_Spur      ISVVAPDVMYAD------------------------------------------------
AqueK485_Aque   FQGLMPDLLFAD------------------------------------------------
AqueK486_Aque   LVDIIPDLLLQD------------------------------------------------
AqueK487_Aque   VSEVAPDLAFAD------------------------------------------------
AqueK488_Aque   LEYLVPDIMFKD------------------------------------------------
AqueK489_Aque   PVAIIPDICDED------------------------------------------------
AqueK490_Aque   LRELIPDYLLVD------------------------------------------------
AqueK491_Aque   ISSLTPDLVFGD------------------------------------------------
AqueK492_Aque   LVDIMPDLLLQD------------------------------------------------
AqueK493_Aque   LVDIMPDLLLQD------------------------------------------------
AqueK494_Aque   LELLSPDILISD------------------------------------------------
AqueK495_Aque   LRRLAPDLLLTD------------------------------------------------
AqueK496_Aque   VVQTVPDLSFSD------------------------------------------------
AqueK497_Aque   LSTLVPDLLMTD------------------------------------------------
AqueK498_Aque   LEYIAPDTLFLT------------------------------------------------
                      .

LRRK2_Hsap      --------------------LPRN---IM---LN-ND-----------------------
LRRK1_Hsap      --------------------FPAR---LF---LE-NS-----------------------
CG5483_Dmel     --------------------IPDK---HT---IP-SE-----------------------
LRRK2_Mmus      --------------------LPRN---IM---LN-ND-----------------------
LRRK1_Mmus      --------------------FPAR---LF---LE-NS-----------------------
T27C10.5_Cele   --------------------IENA---LT---IH-PD-----------------------
GbpC_Ddis       --------------------IPIP---R----FN-LS-----------------------
Pats1_Ddis      --------------------FTGA---K----IP-FD-----------------------
QkgA_Ddis       --------------------VPT---------FT-DD-----------------------
QkgA_C2d_Ddis   --------------------VPT---------FT-DD-----------------------
Roco10_Ddis     VEIYRDDSFLVPIRSLLLDQFSIC---HFIKEID-YR-----------------------
Roco11_Ddis     --------------------IPI---------LL-ED-----------------------
Roco4_Ddis      --------------------VPT---------LA-DN-----------------------
Roco5_Ddis      --------------------IGPN---FT---LE-YK-----------------------
Roco6_Ddis      --------------------FWGSGSKK----FN-YDQIKMHKEKRILSIKPASFGNNQI
Roco7_Ddis      --------------------NKFS---V----IP-YE-----------------------
Roco8_Ddis      --------------------VSSN---KK---VS-KE-----------------------
Roco9_Ddis      --------------------LRHK---L----ID-FK-----------------------
LRRKd_Spur      --------------------LSIR---HF----K-QE-----------------------
LRRKc_Spur      --------------------LSIR---HL----K-QE-----------------------
LRRKb_Spur      --------------------LEDK---FL---LD-PR-----------------------
LRRKa_Spur      --------------------LGPS---VL---TE-KS-----------------------
AqueK485_Aque   --------------------CPAQ---SF---IT-PL-----------------------
AqueK486_Aque   --------------------LDAD---YL---LK-PE-----------------------
AqueK487_Aque   --------------------LPSS---IL---YR-KG-----------------------
AqueK488_Aque   --------------------LSRV---K----LD-RN-----------------------
AqueK489_Aque   --------------------FVMI---SM---IK-LN-----------------------
AqueK490_Aque   --------------------LPPS---LQ---LN-QD-----------------------
AqueK491_Aque   --------------------LPTH---YI---IN-EK-----------------------
AqueK492_Aque   --------------------FDAD---YL---LK-SE-----------------------
AqueK493_Aque   --------------------LDAN---YL---LK-SE-----------------------
AqueK494_Aque   --------------------LDPQ---YH---VS-RD-----------------------
AqueK495_Aque   --------------------FSGE---LR---LK-KE-----------------------
AqueK496_Aque   --------------------LVAT---NED--MDKPR-----------------------
AqueK497_Aque   --------------------LPPN---LI---ID-QS-----------------------
AqueK498_Aque   --------------------EGRD---VL---LQ-PD-----------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      QFEVRVPPSPPPPPVQQIINNGADDNITTTTLAVNNIKVLESGGSQPPSPRSGKDVTHEL
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      --------------------------------------------ELEFEQ---APEFL--
LRRK1_Hsap      --------------------------------------------KLEHSE---DEGSV--
CG5483_Dmel     --------------------------------------------CI-------IKGSL--
LRRK2_Mmus      --------------------------------------------ELEFEE---APEFL--
LRRK1_Mmus      --------------------------------------------KLEHTE---GENSI--
T27C10.5_Cele   --------------------------------------------QL-------KRSRM--
GbpC_Ddis       --------------------------------------------EVKI-------NKE--
Pats1_Ddis      --------------------------------------------QLMI-------EEL--
QkgA_Ddis       --------------------------------------------QILY-------ERQ--
QkgA_C2d_Ddis   --------------------------------------------QILY-------ERQ--
Roco10_Ddis     --------------------------------------------EIEV-------LPDHS
Roco11_Ddis     --------------------------------------------QVVC-------EEQ--
Roco4_Ddis      --------------------------------------------EIEY-------EKQ--
Roco5_Ddis      --------------------------------------------DLEI-------IEK--
Roco6_Ddis      PIINRLEIIQPTSDESSLIQVEFDHNNQTLVISGTYKYGDLLEIEFES-------PKL--
Roco7_Ddis      --------------------------------------------TLKF-------GPQ--
Roco8_Ddis      --------------------------------------------DLIY-------QEE--
Roco9_Ddis      --------------------------------------------EVELD------PNP--
LRRKd_Spur      --------------------------------------------DFTLHM---VSGQS--
LRRKc_Spur      --------------------------------------------DFKLHM---VSGQS--
LRRKb_Spur      --------------------------------------------KLNFTQ---RAENL--
LRRKa_Spur      --------------------------------------------ALE-------IQRL--
AqueK485_Aque   --------------------------------------------ESHM-IGI-KVNE---
AqueK486_Aque   --------------------------------------------EIKFQE---DKDSL--
AqueK487_Aque   --------------------------------------------NIS-------KLEV--
AqueK488_Aque   --------------------------------------------MLHDPVDSGNGAGP--
AqueK489_Aque   ------------------------------------------VNIKDM-------SSC--
AqueK490_Aque   --------------------------------------------SFSYQE-----ARP--
AqueK491_Aque   --------------------------------------------LVDR-------GKF--
AqueK492_Aque   --------------------------------------------EIKFQE---DKDSL--
AqueK493_Aque   --------------------------------------------EIKFQE---DKDSL--
AqueK494_Aque   --------------------------------------------SIVMDE--GNPATV--
AqueK495_Aque   --------------------------------------------N----L---VFDKS--
AqueK496_Aque   --------------------------------------------TL--RI---LEKEV--
AqueK497_Aque   --------------------------------------------CFEFNP--KDLSTR--
AqueK498_Aque   --------------------------------------------EVL-------KKER--


LRRK2_Hsap      -L-GDGSFGS-VYRAAYEG---------EEVAVKIFNK----------------------
LRRK1_Hsap      -L-GQGGSGTVIYRARYQG---------QPVAVKRFHIKKF-KNF---------------
CG5483_Dmel     -L-GRGAFGF-VFKANCKSA---------LMAFKVAVG----------------------
LRRK2_Mmus      -L-GDGSFGS-VYRAAYEG---------EEVAVKIFNK----------------------
LRRK1_Mmus      -L-GQGGSGTVIYQARYQG---------QPVAVKRFHIKKF-KNS---------------
T27C10.5_Cele   -L-GRGAFGF-VFRATVRQPNG----ELCEVAQKMLEPVDP-GPG---------------
GbpC_Ddis       -V-GRGAFGI-VYEAEWMS---------EWIALKKLLLPSS-TDT---------------
Pats1_Ddis      -I-GEGGAAL-VYRARWQG---------QTVAVKKLKTIEN-LDS---------------
QkgA_Ddis       -I-GEGGFGL-IHKGKLISN-------KSDIAIKSLILCNS-NNN---------------
QkgA_C2d_Ddis   -I-GEGGFGL-IHKGKLISN-------KSDIAIKSLILCNS-NNN---------------
Roco10_Ddis     NQNENGTSTQ-SMMGMYGK---------QFVNIKVFNAPLL-G-----------------
Roco11_Ddis     -I-GVGGFGL-VHKGKLILQD-----KSLVVAIKSYIVGNS-S-----------------
Roco4_Ddis      -I-GKGGFGL-VHKGRLVKD-------KSVVAIKSLILGDS-E-----------------
Roco5_Ddis      -V-GEGGFGI-VYKGKLRG---------QLVAIKQITIDS--------------------
Roco6_Ddis      -I-GRGASGK-IYRANLND---------TMVAVKQLEVVG--------------------
Roco7_Ddis      -L-GSGSYAN-VYRGIWNG---------SEVAIKVLNFDDG-------------------
Roco8_Ddis      -I-GVGGFSR-VYKGIYKN---------NTVAIKQFNFERM-DLI---------------
Roco9_Ddis      -I-GEGGTAT-VYKGKWRQ---------SDVAIKLLKTDVV-------------------
LRRKd_Spur      -L-GQGGFGE-VFRAKFRG---------ETVAAKTMLPSRLLKNRMFSSASEGYASCAST
LRRKc_Spur      -L-GQGGFGE-VFRAKFRG---------ETVAAKTMFPSRLLKNQMYSSPSEGYASCAST
LRRKb_Spur      -L-GDGSFGS-VYKGTYRDK---------PVAVKVFSKGG--------------------
LRRKa_Spur      -L-GSGTFGL-VFQGVMARASE----HRRPIAAKMLQPYPP-GQG-A-------------
AqueK485_Aque   ---SKGMF----LRHYF--------------SEKIMEPAK--------------------
AqueK486_Aque   -L-GEGGFGK-VYRGKCRG---------KSVAIKKYLTR---------------------
AqueK487_Aque   -L-GSGGFGS-VYKGLIEEGQ-------VTVAIKEFSSIAG-KME---------------
AqueK488_Aque   -V-GCGCFGV-VYHKRLQLEQYDP-DISREVAVKEFRSSDM-D-----------------
AqueK489_Aque   -L-TRPPLET-VFKGEYG---------SVPIAVKPYPPPND-------------------
AqueK490_Aque   -V-YRDNSTI-LYDGTFSG---------NPATVKKHLFSES-------------------
AqueK491_Aque   -V-ASGSFGE-IYHGAIYPHLSASDDEGREVAIKIDKQDRK-------------------
AqueK492_Aque   -L-GEGGFGK-VYRGKFHG---------KSVAIKKYLTR---------------------
AqueK493_Aque   -L-GEGGFGK-VYRGKFRS---------KSVAIKKYLMR---------------------
AqueK494_Aque   -L-GKGGFGE-VFKALYNEK---------SVAIKVFSPRVA-EL----------------
AqueK495_Aque   -E-KSLIEKQ-VYKGTYYN---------QPVAIKVFPIDSS-------------------
AqueK496_Aque   -L-GKGGYGF-VCTGELKGPTGS---PPELVAVKVFLTNLE-GKI---------------
AqueK497_Aque   -L-GRGGAGA-VYKGKYRNV---------PVAVKEFLTQSQ-ADA-F-------------
AqueK498_Aque   -L-GRGAFAT-VYHAQIKRKLPNGQIHFEDVAIKALGNKGE-DLD---------------
                                                 *

LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ----A------------------------------------NV-----------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ----A------------------------------------NA-----------------
T27C10.5_Cele   -GRPS------------------------------------ALAAY--------------
GbpC_Ddis       --TNL------------------------------------NGNGE--------------
Pats1_Ddis      --P---------------------------------------------------------
QkgA_Ddis       --NNS------------------------------------NNNNN--------------
QkgA_C2d_Ddis   --NNS------------------------------------NNNNN--------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      --DSTSFNNLNSLTISPSNSSLSISLSSSTSSLSPPIVNNNNNNNNLNNNLNNLNNNNKL
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      SSSTS------------------------------------NRTGE--------------
LRRKc_Spur      PSSTS------------------------------------NMTGE--------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      -GNTD------------------------------------RRRYD--------------
AqueK485_Aque   --------------------------------------------RH--------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   --D-S------------------------------------LS-----------------
AqueK497_Aque   -QDED------------------------------------ELPPG--------------
AqueK498_Aque   ----D------------------------------------DD-----------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      YIQQQQQTQQNQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQNQQQPKILQRNLST
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ---------------------------------------------HTSLRLLRQELVVLC
LRRK1_Hsap      --------PADTM---------------------LRHL--RATDAMKNFSEFRQEASMLH
CG5483_Dmel     ------------K---------------------WDRD--PLQHSCKAYCTARQELAVLL
LRRK2_Mmus      ---------------------------------------------HTSLRLLRQELVVLC
LRRK1_Mmus      --------PADTM---------------------LRHL--RAMDAMKNFSDFRQEASMLH
T27C10.5_Cele   -----KA-AAD-K---------------------WKRD--SMEFACRAYCTSRQELSLLS
GbpC_Ddis       -----VM-VYD-----------------------DPDQ--LIEDRLRVFREFRHEVYYMS
Pats1_Ddis      -----------------------------------IEI--NDISLSKAFNEFRRECWVMS
QkgA_Ddis       -----SNNSNNF----------------------KNNN--NEDEFIEKFQEFQHEVFIMS
QkgA_C2d_Ddis   -----SNNSNNF----------------------KNNN--NEDEFIEKFQEFQHEVFIMS
Roco10_Ddis     ------------------------------------AD--FQNNCARILSSFRHEALSLY
Roco11_Ddis     -----------------------------------------ASDIIRKFQEFHHEMYIMS
Roco4_Ddis      ----------------------------------------GETEMIEKFQEFQREVFIMS
Roco5_Ddis      -------------------------------------G--QAEAASEIYREFRREVWLSN
Roco6_Ddis      ------------------------------------------EDAPRIFSEFRREIHVMS
Roco7_Ddis      -----------------------------------------HANTTEKYREFRNEAHITG
Roco8_Ddis      SSLSSNSSQGED----------------------SMNQ--ISSGKLNAINEFRREVWLMS
Roco9_Ddis      -----------------------------------------GSDFSKVFAEYRREIFCLS
LRRKd_Spur      -----STSTE------------------------NDSL--EAAMLMESFHKLRNEVAIMA
LRRKc_Spur      -----STSTENDS---------------------CDSL--EAAMLMDSFHKLRNEVAIMV
LRRKb_Spur      --------------------------------------------ESHPHRLLRQEVTVLR
LRRKa_Spur      -----NDN-TKWH---------------------RD----PLRFSCEAYRTARKELSIIN
AqueK485_Aque   -----KG-A----------------------------Q--KTFYLKKHITKLYQDFDLLK
AqueK486_Aque   --------------------------------------------TEEAFNELRSEAKVLQ
AqueK487_Aque   ----------------------------------EDTLIGHELNAWDIYINGSREARMMH
AqueK488_Aque   ----------------------------------YD----AELEVVKSYADMRYELNKLC
AqueK489_Aque   ------------------------------------------RSANNPFLSFWHEITTLQ
AqueK490_Aque   ------------------------------------------KSYSVPLSAMRQELEMLS
AqueK491_Aque   ------------------------------------HF--NMETAAKAYTEIRAEVALLK
AqueK492_Aque   --------------------------------------------QEEAFNELRHEAKLLQ
AqueK493_Aque   --------------------------------------------QEEAFNELCHEAKLLQ
AqueK494_Aque   -------------------------------------------HSTTPNQLIRQEVSILS
AqueK495_Aque   ------------------------------------------ANHFTVLRLHRSELSVLT
AqueK496_Aque   --------SAELL---------------------EEAA--KDSQLRSAYKEIRQEVNFLS
AqueK497_Aque   -----GIH-TYHD---------------------DDSI--SSGEALFLYRDMRQEVTVLA
AqueK498_Aque   --------DEDISLDEEEERPGGDDEYDGENAREPPPI--QRSAIISGFNNLKKELSILS
                                                                      :

LRRK2_Hsap      ----HLHHPSLISLLAAGIRPR-MLVMELASKGSLDRLL-----QQDK------------
LRRK1_Hsap      ----ALQHPCIVALIGISIHPL-CFALELAPLSSLNTVL-----SENARDSS--------
CG5483_Dmel     ----TLKHPNIVPLVGICIKPL-ALVLELAPLGGLDALL-----RHYRRSG---------
LRRK2_Mmus      ----HLHHPSLISLLAAGIRPR-MLVMELASKGSLDRLL-----QQDK------------
LRRK1_Mmus      ----ALQHPCIVSLIGISIHPL-CFALELAPLGSLNTVL-----SENAKDSS--------
T27C10.5_Cele   ----RMKHPNVIGLVGVCTFPL-SLVVELAPLGALNQLL-----GSHRKAG---------
GbpC_Ddis       ----GLNHPNVMKISGFCIQPL-CMALEYVRYGSLYSLL-----SNS---S---------
Pats1_Ddis      ----ELEHPNIVQLKGLCLDPL-CIVTEYLPHGNLYSFL-----HKPE------------
QkgA_Ddis       ----NLNHPNIVKLYGLMHNPP-RMVMEYVEHGDLYHLC-----QDKER-Y---------
QkgA_C2d_Ddis   ----NLNHPNIVKLYGLMHNPP-RMVMEYVEHGDLYHLC-----QDKER-Y---------
Roco10_Ddis     ----NFRHSNVLSIIGISMNPI-AIITENPTFGSKGSTTLSEYIQDRQK-H---------
Roco11_Ddis     ----SLNHLNIVKLFGSMQNPP-RMVMEFAPHGDLYHFL-----EKKK------------
Roco4_Ddis      ----NLNHPNIVKLYGLMHNPP-RMVMEFVPCGDLYHRL-----LDKA------------
Roco5_Ddis      ----TLTHPSIVSLKGYCLDPC-CIVMEYIPNGTLYSHL-----RK--S-F---------
Roco6_Ddis      ----DLKHSNVVNLLGFTLSPF-TMVMEYIDCGDLHKFL-----HSPIGDQ---------
Roco7_Ddis      ----ELRHANTVSLMGVSLSPF-CLVTELLQYGDLAKFI-----RNTA------------
Roco8_Ddis      ----GLSHSNIVLMKGFCFEPY-AIVMEYMDIGSLSSFL-----KKKKEDG---------
Roco9_Ddis      ----SFIHDNILDLKGFCLEPL-AIITEFQSGGNLYDYI-----HDLK------------
LRRKd_Spur      ----KLDHPYIVNLVGVSIRHL-CFAMDYAPLGDLRSYL-----FAEHQSARPHFV---K
LRRKc_Spur      ----KLDHPCIVNLVGVSIRHL-CFAMDYAPLGDLQSYL-----FAEHQSARPHFV---K
LRRKb_Spur      ----HLQHPSLVSMEGVGLNPR-ILVMELAPLGSLNTLL-----ASGRIKN---------
LRRKa_Spur      ----NLDHPHIVPLLGFCRHPM-CLILELAPQGALDTRM-----ENFKRVGA--------
AqueK485_Aque   ----NLSTPHIISSLGFHYSVP-VLALELSPLGSVRKYL-----NDGNKLL---------
AqueK486_Aque   ----ESHHPFLVCLVGVSVHPLMALILEEAPMGSFERHL-----IKKS------------
AqueK487_Aque   ----QLQHKNILSLVGLAFQPL-RLILELAPLGDLKNSL-----KPFRQEK---------
AqueK488_Aque   ----MMEHDFVVEFVGLLTNPW-SFILEWAPLMSLEKIR-----KSYEEQFKTHKP----
AqueK489_Aque   YATQTDQCPYIIDPLLATTDPF-SLVFSFAMFCSMEDVI-----LEHT------------
AqueK490_Aque   ----LLSHPNIIKAYGYCFSPP-SLVIERSPLGTLLQKL-----SDNE------------
AqueK491_Aque   ----DLDHEYIINFIGLTLQPL-CFMLEWASKGSLHGIL-----QSYYRTD---------
AqueK492_Aque   ----KSYHPSIVCLVGVNVHPLTALILEEAPMGSLDRHL-----IKES------------
AqueK493_Aque   ----KSHHPFIVCLVGVNVHPLTALILEEAPMGSLERHL-----IKES------------
AqueK494_Aque   ----QMDHPNIIGLVGVCLRPKPMLLIEYAELGSLSSFS-----PYS--T----------
AqueK495_Aque   ----NISHQYLISTAGFLTAPL-SIVFPLAPLGSLQDHL-----DLCP------------
AqueK496_Aque   ----TLKHQNITKLIGVRTKPVYCLLLELAPMKSLRSML-----KDYQLCK---------
AqueK497_Aque   ----QLSHPNIVSILGVSLRPM-CIALELAPMGSLFGIL-----DKKLEAIKTAQADLPT
AqueK498_Aque   ----PLRHPYIIQLFGVSARPL-GLVLELAPKGSLKSLL-----KEYSEAQ---------
                                        :

LRRK2_Hsap      -------ASLTRTLQHRIA----------LHVADGLRYLHSA--MIIYRDLKPHNVLLFT
LRRK1_Hsap      ------FIPLGHMLTQKIA----------YQIASGLAYLHKK--NIIFCDLKSDNILVWS
CG5483_Dmel     -------AHMGPHTFQTLV----------LQAARAIEYLHRR--RIIYRDLKSENVLVWE
LRRK2_Mmus      -------ASLTRTLQHRIA----------LHVADGLRYLHSA--MIIYRDLKPHNVLLFT
LRRK1_Mmus      ------FMPLGHMLTQKIA----------YQIASGLAYLHKK--NIIFCDLKSDNILVWS
T27C10.5_Cele   -------TKLSLGVIKESA----------VQVARALEYLHSA--HIIYRDLKSENVLGWR
GbpC_Ddis       -------IEISWGLRLQIA----------SEIAKGMQHLHSHNPPVIHRDLKSPNILLNG
Pats1_Ddis      -------MEFSWLFRLKVA----------LDISSGMAFLHSSTPPIIHRDLKSPNILLAS
QkgA_Ddis       -------ASLGWTLKLRLM----------IDIAKGIGYMQNQNPPIVHRDLRSPNIFLKS
QkgA_C2d_Ddis   -------ASLGWTLKLRLM----------IDIAKGIGYMQNQNPPIVHRDLRSPNIFLKS
Roco10_Ddis     -------PEIPWNIKLKIA----------LDIARAMDKLNSHSPPFLLTNLTSSGIILEK
Roco11_Ddis     --------NIKWSFKVRLM----------LDIAKGIEYLQNQNPPIVHRDLRSPNIFLFS
Roco4_Ddis      -------HPIKWSVKLRLM----------LDIALGIEYMQNQNPPIVHRDLRSPNIFLQS
Roco5_Ddis      -------SSITWQLKLKIA----------INIADAIKHMHGFTPKICHRDLKSPNILMLS
Roco6_Ddis      -------LNGNWALILKLA----------LDIAKGMEFLHSVTPPLLHRDLKSPNVLLSM
Roco7_Ddis      -------ETFSWGTVLKLA----------IDVAKGMNFLHSCKPMIVHRDLKSANILLGG
Roco8_Ddis      -------QVLDWQMLLKIV----------TDIASGMAFLHNITPPLVHRDLKSPNILLAS
Roco9_Ddis      -------NPLDWQLRIKIA----------KGIAASLQTLHDSRPSVVHRDLKSPNILLSS
LRRKd_Spur      RNIV-LEPVLSRMLTYKIS----------LQVASAVGYLHRK--DIIYCDLKTDNILLFS
LRRKc_Spur      RNIV-LEPVLSRMLTYKIS----------LQVASAVGFLHSK--DIIYCDLKTDNILLFS
LRRKb_Spur      -----------RNLQHRIA----------MQVAEGLAFLHKN--RIVYRDLKPDNVLIFS
LRRKa_Spur      --------RLTPHTLQELV----------VQVSSAVAYLHSK--DIIYRDLKAENVLVWK
AqueK485_Aque   -----------QSGVHQIALQLLKNWAKEYRVLSAIKYLDTN--SLNYHCLTCDNVLLWL
AqueK486_Aque   -------TPIPRLTMFRIA----------AQVAAALRFLHQH--GIIFRDLKAANVLLWS
AqueK487_Aque   -------IKLNCRTLKQLI----------YQVADA-------------------------
AqueK488_Aque   -----EYYYLCPVSLYLIL----------LQVCDGLHYLHAPPIGIIHSDLKLSNILAYR
AqueK489_Aque   -------ISVSPFLRMRIV----------YQLASALKTLHSL--KIIHRNVCLENIIVYS
AqueK490_Aque   -------QKISRLVRFHIS----------CQVASALAYLHKH--NVIYRTLKSDSVLTWS
AqueK491_Aque   -------SKVSPWTLVEAG----------RQVANGLSYLHSR--NVVYYDLKSPNILVFE
AqueK492_Aque   -------TPIPRLTMFRIA----------AQVAAALRFLHQH--GIIFRSLKAANVLLWS
AqueK493_Aque   -------TLIPRLTMFRIA----------AQAAAALRFLHQH--GIIFRSLKAANVLLWS
AqueK494_Aque   ---------VSPSLKHRIA----------MQVASALAFLHKN--NIIYRDLKPSNILIFS
AqueK495_Aque   -------SGIGDKISHVLL----------HQVAQGLQYLHSL--HIIHRDIKPGNILVWS
AqueK496_Aque   -------LTMEPITLKQCA----------KQISDGLNYLHTH--QIVHLDMKSPNVLVWE
AqueK497_Aque   ANIKMPGGVLGHQISARIA----------LQVALATRYLHKI--GIVYRDLKSDNVLIWS
AqueK498_Aque   -------THIQSSAMQAVT----------LQISDALKYLHDL--RIIYRDLKSDNVLVWQ
                                                  .

LRRK2_Hsap      LYP-------------------------N-------------------AAIIAKIADYGI
LRRK1_Hsap      LDV-------------------------K-------------------EHINIKLSDYGI
CG5483_Dmel     LPQPHTE------------------DSPR-------------------NLVHIKIADYGI
LRRK2_Mmus      LYP-------------------------N-------------------AAIIAKIADYGI
LRRK1_Mmus      LSA-------------------------K-------------------EHINIKLSDYGI
T27C10.5_Cele   FPAPF---------------------SPQ-------------------TDVLLKLGDYGI
GbpC_Ddis       IT-------------------------EG-------------------QNSVATIIDFGT
Pats1_Ddis      IN-------------------------EN-------------------AQTIAKVVDFGL
QkgA_Ddis       LD-------------------------EN-------------------SPVCAKIADFGL
QkgA_C2d_Ddis   LD-------------------------EN-------------------SPVCAKIADFGL
Roco10_Ddis     SNDHQSSGNGLE---------------IE-------------------PFVNAKIIDFSQ
Roco11_Ddis     LD-------------------------EN-------------------APVCAKVADFGL
Roco4_Ddis      LD-------------------------EN-------------------APVCAKVADFGL
Roco5_Ddis      D--------------------------MN-------------------AAVVCKVSDFGE
Roco6_Ddis      KD----------------------------------------------GVYTAKVGDFGL
Roco7_Ddis      SS-------------------------M-D-------------------NLVAKVGDFGL
Roco8_Ddis      HP-------------------------TNP------------------NEISAKVSDFGL
Roco9_Ddis      KD-------------------------S-L------------------T-MECHLCDFSL
LRRKd_Spur      SDV-------------------------N-------------------EDVNIKLIDYGI
LRRKc_Spur      SDV-------------------------N-------------------EDVNIKLTDYGI
LRRKb_Spur      LAL-------------------------G-------------------TLQNAKISDYGI
LRRKa_Spur      FPQPYS------------------P-NPA-------------------DPIKVKLADYGI
AqueK485_Aque   LE-----------------------------------------------PVTVKLSDSGL
AqueK486_Aque   LDE-------------------------T-------------------SLCHSKKEKC--
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   FPKMDHNCCSSVQGRGYCSECLPEP-GHS-------------------YKVLVKLGDMGV
AqueK489_Aque   LS-------------------------LDE-------------------QVNIKLGGFSR
AqueK490_Aque   LE-------------------------FE-------------------DEVSVKLAHFDR
AqueK491_Aque   FP-------------------------SADESLRVSLESSPVLDKLGKFPVHVKITDLGI
AqueK492_Aque   LDE-------------------------T-------------------SLCHSKLTDFGI
AqueK493_Aque   LDE-------------------------T-------------------SLCHSKLTDFGI
AqueK494_Aque   LSL-------------------------N-------------------SPVNAKLSDYGI
AqueK495_Aque   LTL-------------------------S-------------------DGILVKITDYGS
AqueK496_Aque   FPIAGMPRK-------------ERL-KYA-------------------GNVWLKIADYGI
AqueK497_Aque   LDV-------------------------N-------------------ESVNAKLADYGI
AqueK498_Aque   FPSPYDVLV-------------PALPVHT-------------------DVVKVKLSDYGI


LRRK2_Hsap      AQYCCRM-GI----KTS-EGTPGFRAPE------VAR---GNVIYNQQADVYSFGLLLYD
LRRK1_Hsap      SRQSFHE-GA----LGV-EGTPGYQAPE------IRP----RIVYDEKVDMFSYGMVLYE
CG5483_Dmel     SRQTAPS-GA----KGF-GGTEGFMAPE------IIRYN-GEEEYTEKVDCFSFGMFIYE
LRRK2_Mmus      AQYCCRM-GI----KTS-EGTPGFRAPE------VAR---GNVIYNQQADVYSFGLLLHD
LRRK1_Mmus      SRQSFHE-GA----LGV-EGTPGYQAPE------IRP----RIVYDEKVDMFSYGMVLYE
T27C10.5_Cele   SRSVLPSGGA----KGF-GGTEGFMAPE------IVRFN-GEEEYTQKVDCFSFGMFLYE
GbpC_Ddis       STALYGG-AAL----IRCVDQPLWLGPE------VLA----GTAYSEPSDVYSFGIILWE
Pats1_Ddis      SGLQHTI--TN----RG-VENPLWLAPE------ILNK---TKEASTQTDVYAFGVILWE
QkgA_Ddis       SQQSVYS--VS----GL-LGNFQWMAPE------TIGVE--DESYTEKVDTYSFAMILFT
QkgA_C2d_Ddis   SQQSVYS--VS----GL-LGNFQWMAPE------TIGVE--DESYTEKVDTYSFAMILFT
Roco10_Ddis     SSFLPSL--F-----PTSTTPKSYHSPE------VLQ----KLNYHENSDVYSFGIILYE
Roco11_Ddis     SQQSLYS--VS----GL-LGNFQWMAPE------TIGA---EESYTEKIDTYSFSMILFT
Roco4_Ddis      SQQSVHS--VS----GL-LGNFQWMAPE------TIGAE--EESYTEKADTYSFAMILYT
Roco5_Ddis      TRAVVTS-ALG----RDKLSNPIWLSPE------IMR----GDEYTEKADVYSFGIVLWE
Roco6_Ddis      SSRMFIQ-ALKHKLRNFPVGNITWVAPE------ILR----EEEYTVKSDVYAFGLILHE
Roco7_Ddis      SIKPIGK-EVK----GRKVWNWRWLAPE------CMG----DGQYTEKIDIYSYAIVLWE
Roco8_Ddis      SRSIVQN-FSS----KV-VDNPTWQSPE------VLK----GMEYNEKSDIYSFGMILWE
Roco9_Ddis      SGFSTTV--AN----RS-VQNPVWLAPE------VIN----NELCSDKSDVYAYGVILFE
LRRKd_Spur      SKKYDLM-GA----MGM-AGTPGFCAPE------ILQ----GKTFDEKVDWFSYGMFLYH
LRRKc_Spur      SRKYDLM-GA----MGM-AGPPGFCAPE------ILQ----GKVFDEKVDWFSYGMFLYH
LRRKb_Spur      SRFATPY-GL----KSS-EGTPGYRAPE------VIRG---TSNYNTEVDIYSFGILLYE
LRRKa_Spur      SVTALPS-GT----KGY-GGTPGYMAPE------IVQYD-GKETYNEKVDCFSFGMFMFE
AqueK485_Aque   LHSPADCI-L----CST-LNTT-V------------TAS-TRKAKMFRFNLIMFGLFLYE
AqueK486_Aque   ---MV-----------V-SGAKGFQSPLEGYPLDDFPQTE--EDKSQPLD-NSGEMILWE
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   SVNPAAH-NH-----DA-LGV-KRFAPE------ASNT-----KLTEK------------
AqueK489_Aque   SCLEMSQ-GL-----A-VGEHGRFPAPE------MSNY---LYEYDQRADVFSFAFTSYE
AqueK490_Aque   AAFSTPT-GIL----SK-TDFSFYPAPE------MVRYE-FSEEYTEKVDIYSFGILLYE
AqueK491_Aque   SRKITPG-GVV----G-YKGTPAFMAPE------ILRYV-GKEACTEKVDVFSFGMFMYE
AqueK492_Aque   ATHLAPL-GV----MGI-QGDKCVIAPE------VLYIGQKRTIYNHKADIFSFGMLLYQ
AqueK493_Aque   ATHLAPL-GV----MGI-QGDKSVIAPE------VLYIGQKRTIYNHKADIFSFGMLLYQ
AqueK494_Aque   STFATTT-GL----NQD-IGTAGYKAPE------ILKAKTSKMPYNTMVDIYSFGIVLFQ
AqueK495_Aque   SYYIDTF-GC----KGS-RGTEDYMAPE------LYLSA-RKRNYDEKVDIFSFGILLFN
AqueK496_Aque   SQVATSM-MMKV-TTNQ-PGTPGYMAPE------LFET--GQEIYSTKVDVFAYGMTLYE
AqueK497_Aque   SRFANPG-GI----KGE-EGTPGYMAPE------AIKRRGEDQAFDEKVDIFSFGMLLFE
AqueK498_Aque   SQFASTQ-GA----KGL-VGTPGFMAPE------ILMYY-GKEAYNEKVDIFSFAMLIYE


LRRK2_Hsap      ILTT-GGRIVEGLKF------PNEF-----------------------------------
LRRK1_Hsap      LLSG-QR-PALGHH-------QLQI-----------------------------------
CG5483_Dmel     NISL-RQ-PFEGHES---------I-----------------------------------
LRRK2_Mmus      IWTT-GSRIMEGLRF------PNEF-----------------------------------
LRRK1_Mmus      LLSG-QR-PALGHH-------QLQI-----------------------------------
T27C10.5_Cele   LLTL-KF-PFESEEH---------V-----------------------------------
GbpC_Ddis       LYTR-AH-PFDEFQ-FGQ--WMSKL-----------------------------------
Pats1_Ddis      LVTR-KD-YFGEIG-F-----MTLI-----------------------------------
QkgA_Ddis       ILTG-EI-PFDEYS-FG---KMQFI-----------------------------------
QkgA_C2d_Ddis   ILTG-EI-PFDEYS-FG---KMQFI-----------------------------------
Roco10_Ddis     LLTR-SI-AFQDHD---------RF-----------------------------------
Roco11_Ddis     ILTG-EC-PFDEFTSFG---KMEFI-----------------------------------
Roco4_Ddis      ILTG-EG-PFDEYS-YG---KIKFI-----------------------------------
Roco5_Ddis      ILTG-LL-PFDEYP-VAHSSFMYQL-----------------------------------
Roco6_Ddis      LLTR-KH-PYREFN-YSM---VSLQ-----------------------------------
Roco7_Ddis      IITR-DL-PFEEYVDQL--KWNSII-----------------------------------
Roco8_Ddis      CYHL-EL-PFDEFD-FK---FMSTL-----------------------------------
Roco9_Ddis      LLSR-TR-FFSNIT------FMSEV-----------------------------------
LRRKd_Spur      LMTG-LV-PYYDQHS------RIEI-----------------------------------
LRRKc_Spur      LMTG-LV-PYYDQHS------RIEI-----------------------------------
LRRKb_Spur      LVSEGHR-PFEEMEF------RTEI-----------------------------------
LRRKa_Spur      LMSL-QR-PFECLVGKDVGRLSEVI-----------------------------------
AqueK485_Aque   LTLH-RR-AYEDIMS---------L-----------------------------------
AqueK486_Aque   AYSR-AT---------------LRQ-----------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ILTR-KK-LKC-RK---G----VRF-----------------------------------
AqueK490_Aque   LVAR-WQ-PFTSDKT---------------------------------------------
AqueK491_Aque   LLAQ-QF-PFERQN-LMH----NQI-----------------------------------
AqueK492_Aque   MIAR-RH-PFHNVQ-------PVRI-----------------------------------
AqueK493_Aque   MIAR-RH-PFHNVQ-------PVRI-----------------------------------
AqueK494_Aque   LVTDGHT-PFEELMP-------HEK-----------------------------------
AqueK495_Aque   VVTG-KK-FAPNFN-------RSRHEAGGRREAFLSIPHLSIIASAIEEQRLVGSSNQSP
AqueK496_Aque   IISL-QA-PFQKQE-------AMKR-----------------------------------
AqueK497_Aque   LITG-QR-PFESMST------GQEV-----------------------------------
AqueK498_Aque   MITF-RL-PFEHLT-------PSQA-----------------------------------


LRRK2_Hsap      -DELEI---QGKL-P-D--------PVKE-------------------------------
LRRK1_Hsap      -AKKLS---KGIR-P-V--------LGQP-------------------------------
CG5483_Dmel     -KECIL---EGSR-P-A--------LTQR-------------------------------
LRRK2_Mmus      -DELAI---QGKL-P-D--------PVKE-------------------------------
LRRK1_Mmus      -VKKLS---KGIR-P-V--------LGQP-------------------------------
T27C10.5_Cele   -KERML---DGAR-P-V--------LLPH-------------------------------
GbpC_Ddis       -EDEII---RGLR-P-T--------IPPT-------------------------------
Pats1_Ddis      -EEKVI---NGER-P-K--------IPED-------------------------------
QkgA_Ddis       -NLIRE---ENLR-P-T--------LPFD-------------------------------
QkgA_C2d_Ddis   -NLIRE---ENLR-P-T--------LPFD-------------------------------
Roco10_Ddis     -SNIVI---SGQR-P-S--------IPLD-------------------------------
Roco11_Ddis     -RKIRE---EDLR-P-T--------IPSD-------------------------------
Roco4_Ddis      -NMIRE---EGLR-P-T--------IPED-------------------------------
Roco5_Ddis      -EDEIT---NGLR-P-T--------IPQN-------------------------------
Roco6_Ddis      -EDAIK---NGLR-P-T--------ISPS-------------------------------
Roco7_Ddis      -EDKIM---KGLR-P-T--------IPNE-------------------------------
Roco8_Ddis      -EDNIL---SGLR-P-S--------INQN-------------------------------
Roco9_Ddis      -EGLIT---EGVR-P-S--------LPSH-------------------------------
LRRKd_Spur      -ELAVN---EGRK-P-T--------FNFH-------------------------------
LRRKc_Spur      -QLAVN---EGRK-P-T--------FNFH-------------------------------
LRRKb_Spur      -DEAVI---KGQHLP-P--------ISQG-------------------------------
LRRKa_Spur      -KQLIK---DGQR-P-V--------LSRK-------------------------------
AqueK485_Aque   -PTLILALYHQQL-VLNVEADLKHNQSQV-------------------------------
AqueK486_Aque   -MK-II---EEES-P-G--------YLDNHKTVARMIKNFKFKDDTHIVEDLTATTTDES
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   -QTATG---NADR-P-N--------LKPL-------------------------------
AqueK490_Aque   -----A---MAHK-P-K--------LTGL-------------------------------
AqueK491_Aque   -EKLVV---DGAR-P-S--------IQNK-------------------------------
AqueK492_Aque   -DTKVV---QGDR-P-S--------TVDM-------------------------------
AqueK493_Aque   -DTKVV---QGDR-P-S--------TVDM-------------------------------
AqueK494_Aque   -DKAVE---EGRL-I-K--------DPSY-------------------------------
AqueK495_Aque   ATLLLK---DGVH-P-A--------AREG-------------------------------
AqueK496_Aque   -NAEVR---AGKR-P-P--------TGN--------------------------------
AqueK497_Aque   -NRAVI---QRER-P-Q--------VSEG-------------------------------
AqueK498_Aque   -NQANE---NGAR-P-T--------LKRI-------------------------------


LRRK2_Hsap      -----Y---GCA-------------------PWPMVEKLIKQC-----------------
LRRK1_Hsap      ---------EEV-------------------QFRRLQALMMEC-----------------
CG5483_Dmel     ---------ETQ-------------------FPTCCLDLMVLC-----------------
LRRK2_Mmus      -----Y---GCA-------------------PWPMVEKLITKC-----------------
LRRK1_Mmus      ---------EEV-------------------QFHRLQALMMEC-----------------
T27C10.5_Cele   ---------ELL-------------------LPTPMLDLLVHC-----------------
GbpC_Ddis       ----C---------------------------PPEYVELIQSC-----------------
Pats1_Ddis      -------------------------------CPEMYSKLIVEC-----------------
QkgA_Ddis       -------------------------------CDPRLSNLIQLC-----------------
QkgA_C2d_Ddis   -------------------------------CDPRLSNLIQLC-----------------
Roco10_Ddis     -------------------------------CLPSFADLIKDC-----------------
Roco11_Ddis     -------------------------------CPPTISNLIELC-----------------
Roco4_Ddis      -------------------------------CPPRLRNVIELC-----------------
Roco5_Ddis      ----SV-----C-------------------GHPDFITLITDC-----------------
Roco6_Ddis      ----YT---QTV-------------------TGHEYCGLIQDC-----------------
Roco7_Ddis      -------------------------------CPPDMKQLITDC-----------------
Roco8_Ddis      -------------------------------CNRMYSSLITKC-----------------
Roco9_Ddis      -------------------------------NLPEYDSLLNIC-----------------
LRRKd_Spur      ----EYTMPPKQ-------------------VFPALGALMESC-----------------
LRRKc_Spur      ----EYKMPPRQ-------------------VFPALGALMESC-----------------
LRRKb_Spur      ---------GVA-------------------PWPDLQELIDHC-----------------
LRRKa_Spur      ---------EKS-------------------YPTYMLDLLSWC-----------------
AqueK485_Aque   ---------KAC-------------------YKLCMQSVIQLC-----------------
AqueK486_Aque   ESSPSA---SADDTRETFKPFETSYTPNDHSPDPR-SSIISSMSSAEESQMQSESGEDVP
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ---------DPA-------------------YPIPLYTTLDQC-----------------
AqueK489_Aque   ----NG-------------------------LCPYFTPLLDKC-----------------
AqueK490_Aque   ----ST-----Y-------------------GFGSLVKLMEEC-----------------
AqueK491_Aque   ----V--------------------------TSACIVTLPIDI-----------------
AqueK492_Aque   ----PI---AET-------------------GYFFLTRLMEKC-----------------
AqueK493_Aque   ----PI---AET-------------------GYFFLTRLMEKC-----------------
AqueK494_Aque   --------YGGA-------------------PWPDMHDIIRHC-----------------
AqueK495_Aque   ----H---ISTC-------------------ISTCMQVILEDC-----------------
AqueK496_Aque   --------KEKH-------------------TPLLLQDLMRLC-----------------
AqueK497_Aque   --------NMEP-------------------SFPGMIELMEDC-----------------
AqueK498_Aque   ---------DLP-------------------CPVLIRELMVWC-----------------


LRRK2_Hsap      -------LKENPQERPTSAQVFDILNSAELVCL-TR---------RILLPKN--------
LRRK1_Hsap      -------WDTKPEKRPLALSVVSQMKDPTFATF-MY---------ELCCGKQ--------
CG5483_Dmel     -------WHEQPRRRPTASQIVSILSAPECIHL-LD---------VVAMPHS--------
LRRK2_Mmus      -------LKENPQERPTSAQVFDILNSAELICL-MR---------HILIPKN--------
LRRK1_Mmus      -------WDTKPEKRPLALSVVSQMKDPTFATF-MY---------MLPCGKQ--------
T27C10.5_Cele   -------WSAHPESRPSSSQLVGFCAAPEFTHL-LD---------VCELGEA--------
GbpC_Ddis       -------WTHEPNSRPTFTSIVEILGQIKKKFAPLPFTHPPHIRNMMRKSRS--------
Pats1_Ddis      -------WQTDASQRPKFSEIEDRLIKIAEAMF-PD--------IHL-------SNIYQQ
QkgA_Ddis       -------WSTNPKKRPSFTFIIKELLEIRIDSI-QT--------S---------------
QkgA_C2d_Ddis   -------WSTNPKKRPSFTFIIKELLEIRIDSI-QT--------S---------------
Roco10_Ddis     -------WSGEPLNRPSPSKIISQLYTIKKEIE-SK--------EHSY------KSL---
Roco11_Ddis     -------WSGDPKKRPHFSYIVKELTNFYYNLN-L----------------------SPI
Roco4_Ddis      -------WSGDPKKRPHFSYIVKELSELRNGNT-TS--------T------------TTN
Roco5_Ddis      -------WQNDPLKRPTFIDIHSRLLIMSGL-N-PA--------TATT------T-N---
Roco6_Ddis      -------WDSDIDRRPTFNKIVKRIKQIIGRD--VN--------NILMVNGV--------
Roco7_Ddis      -------WSGDPKKRPSFNSILERLSTMQKTFN-LN--------ERLEFCKQL-PPINED
Roco8_Ddis      -------WNADPNLRPSFNSILKTLNEIK-------------------------------
Roco9_Ddis      -------WAQDPTCRPSFIEITKKLEEIELILK-TH--------TPV-------EPVYTE
LRRKd_Spur      -------WQNKPGERPHGETTLQLLSEPSFLCL-RR---------VVEVEEE--------
LRRKc_Spur      -------WQDKPGKRPHGKTILQLLSEPSFLCL-RR---------VVEVEEE--------
LRRKb_Spur      -------TEHVPESRPTAQEAFEKLSSAEMLCL-KQ---------ASALLSG--------
LRRKa_Spur      -------WAQDSRDRPSMEQIKDVSKTAEFANL-LE---------VLSLEEK--------
AqueK485_Aque   -------IGMGEL---TFRGLESRLSLCAGEN-------------------N--------
AqueK486_Aque   LYDSSSRSSLEPIENPSTSEVDAR------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   -------WQQEPNARPSAKTIRNYLQKTTGLLV-KN---------RFQLPAKNMYHLL--
AqueK489_Aque   -------WNNDPHKRPYFIEILHQFTKPMPVLT-RE---------GYCINETH-------
AqueK490_Aque   -------WEEDPTLRPSALDLLHLLSEPQFQCH-LS---------TQTLRDCV-------
AqueK491_Aque   -------SSQVPDDGSTSETSLT--------------------------PSVS-------
AqueK492_Aque   -------WKDKADDRPETSELISD------------------------------------
AqueK493_Aque   -------WKDKADDRPETSELISDVSKVTFQSI-MG---------VLPVRSR--------
AqueK494_Aque   -------LQYVPNNRPRAQDIFDRMCMPDFMAL-RH---------VVPIHED--------
AqueK495_Aque   -------LSIDPIKRPTAEGVASRLVICVGPYT-QE---------KYVLDQN--------
AqueK496_Aque   -------WSKDPSARPKMKECLQWTSTAEFERL-RA---------QLTLGSC--------
AqueK497_Aque   -------WRHLAADRPTADEVVQRISAPGFLCR-RH---------TVSRVQQ--------
AqueK498_Aque   -------WQQSEELRPTASQITKVSQMDQFLRL-AD---------AIRVNNF--------


LRRK2_Hsap      --------------------------------------------------V--------I
LRRK1_Hsap      --------------------------------------------------T--------A
CG5483_Dmel     --------------------------------------------------E--------K
LRRK2_Mmus      --------------------------------------------------I--------I
LRRK1_Mmus      --------------------------------------------------S--------A
T27C10.5_Cele   --------------------------------------------------L--------P
GbpC_Ddis       -----------------------------------------------------------S
Pats1_Ddis      QQQQQQQQQQSSPSKS--------SSTSP--------------------IIKSLN---LS
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     -------------A-----------------------------------SDN-------N
Roco11_Ddis     ------------PE-----------------------------------------QKS--
Roco4_Ddis      ------------TSS----------------------------------TTNNLNSANVS
Roco5_Ddis      -------------S-----------------------------------AKS-------T
Roco6_Ddis      -----------------------------------------------------------S
Roco7_Ddis      QINQQQQ--QPPP-QSQAAQQQQPSTSTPPLSQHQQKLSISNLQLNNLLNNHNSNGSNSS
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      TS----------------------KN--------------------------------QH
LRRKd_Spur      --------------------------------------------------E--------G
LRRKc_Spur      --------------------------------------------------E--------G
LRRKb_Spur      --------------------------------------------------V--------N
LRRKa_Spur      --------------------------------------------------P--------V
AqueK485_Aque   --------------------------------------------------W--------S
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------DTFQI-SSD-----------------------------------S--------N
AqueK489_Aque   -EYN-ASAVRYN-RESNGTFSC--------------------------------------
AqueK490_Aque   -----------------------------------------------------------S
AqueK491_Aque   -QYH-TNVVRG-------DLQE--------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   --------------------------------------------------F--------S
AqueK494_Aque   --------------------------------------------------W--------E
AqueK495_Aque   --------------------------------------------------W--------H
AqueK496_Aque   --------------------------------------------------T--------A
AqueK497_Aque   --------------------------------------------------H--------P
AqueK498_Aque   --------------------------------------------------GS-------Q


LRRK2_Hsap      VECMVAT---------HHN------------SRN--------------------------
LRRK1_Hsap      F---FS-------------------------------SQ---------------------
CG5483_Dmel     IVCGVFQ---------SLV-------------------G---------------------
LRRK2_Mmus      VECMVAT---------NLN------------SKS--------------------------
LRRK1_Mmus      F---FS-------------------------------SQ---------------------
T27C10.5_Cele   PTQLMAV---------GIT------------------DE---------------------
GbpC_Ddis       SISEAML---------PS-------------NLLHLNLNGINNNNNNSNNNNNSIPVTTI
Pats1_Ddis      --TVSEL---------GE-------------SS---------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     IYSDHPL----------P-------------SGGSI------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      IASTSSN---------AD-------------DGSQT--NNNNNNNNNNNNNNNNNSGSSI
Roco5_Ddis      ISTGFNS----------N-------------SGATT------------------------
Roco6_Ddis      VVSGIQS---------PN-------------SLADSQPFHYHQQ-------------QQP
Roco7_Ddis      IQSSLS----------HN-------------NNNLN--NNINNNNNNNNNNNNNSSGGSS
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      IQ----------------------------------------------------------
LRRKd_Spur      VSLAFS-------------------------------QG---------------------
LRRKc_Spur      VSLAFS-------------------------------QG---------------------
LRRKb_Spur      VECQAVR---------TY--------------------Q---------------------
LRRKa_Spur      VSCAVAT---------TAG------------C------S---------------------
AqueK485_Aque   PLKL-TL---------DME------------------VL---------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   VTHACIV---------PPS------------P------L---------------------
AqueK489_Aque   ------------------------------------DL----------------------
AqueK490_Aque   VRGCCYV---------P--------------SLS--QVWA--------------------
AqueK491_Aque   ------------------------------------EV----------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   LKCGCAI---------TPH------------DYV---K----------------------
AqueK494_Aque   VLAFTVR---------NY--------------------H---------------------
AqueK495_Aque   IQEAVFL-----------P------------EKGEILAWE--------------------
AqueK496_Aque   ISCACVS---------RIE------------PKYE-SEWI--------------------
AqueK497_Aque   LQKIDTI---------YC--------------------Q---------------------
AqueK498_Aque   VAGSCYRILKSPVFKPSLTPHTPGHHSFPFVPSLK-SQGA--------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ---------------------G--------------------------------------
CG5483_Dmel     ----------M----------G--------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ---------------------S--------------------------------------
T27C10.5_Cele   ----------I----------D--------------------------------------
GbpC_Ddis       SLTSSGTSPTN---------SPVGGLLSQSLTQP--------------------------
Pats1_Ddis      ----N-QTP-----------KQNITTTTTTTHSD--------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ----I-Y-------------QDKIIH----------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ALSPS-RSF-----------EQQTTTTTTTTTSP--------------------------
Roco5_Ddis      ----T-TKP-----------KSSTIS----------------------------------
Roco6_Ddis      SLNST-----N---------QLQQQQYSSVLTSP--------------------------
Roco7_Ddis      GVSHS-GSS-----------G---------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      -L----------------------------------------------------------
LRRKd_Spur      ---------------------S--------------------------------------
LRRKc_Spur      ---------------------A--------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      --------PEGDG--------P--------------------------------------
AqueK485_Aque   ----------L----------T--------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   --------PPPPS--------P--------------------------------------
AqueK489_Aque   YIC-------S---------SVLSMK----------------------------------
AqueK490_Aque   ----------Y---------GEYNVN----------------------------------
AqueK491_Aque   WFC-------S---------KEKDDQ---TLER---------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   --------PKG----------N--------------------------------------
AqueK495_Aque   ------------RDGQRR------------------------------------------
AqueK496_Aque   -------EPADTVKSENSLPTVMNGTL--LT---REEIERFGLDVDILLASQDCLEIEES
AqueK497_Aque   --------PVINE--------S--------------------------------------
AqueK498_Aque   -------SPLRTSIKASSIPTNETGSRAAVSNQPQSKIDSNPNQVDI-------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ----------------ITSGGSTSGILSTS------------------------------
Pats1_Ddis      ----------------H----------KRQLS----------------------------
QkgA_Ddis       --------------------------------Y---------------------------
QkgA_C2d_Ddis   --------------------------------Y---------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ----------------S----------SPSTSF---------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ----------------R----------SNL------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ----------------D----------STVLTH---------------------------
AqueK490_Aque   ------------------------------IG----------------------------
AqueK491_Aque   ----------------A----------SSRLSF---------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------VVSINEETFSTEL-----------------
AqueK496_Aque   IIKTKEVVVSDDPGSDE----------ERGLENLSTEEKKKETE-DDRVMKKSDKLAS--
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   --NPKEEGLLSKACNES----------GHNLMFNSTEKQLLEAAAEIRANETSLPLTEAQ


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ----------------------------------------------------------DD
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ----------------------------------------------------------DP
GbpC_Ddis       ----------------------------------------------------------VN
Pats1_Ddis      ----------------------------------------------------------TD
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ----------------------------------------------------------FG
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ----------------------------------------------------------IN
Roco5_Ddis      ----------------------------------------------------------SG
Roco6_Ddis      ----------------------------------------------------------SD
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      -----------------------------------------------------------N
LRRKd_Spur      ----------------------------------------------------------QD
LRRKc_Spur      ----------------------------------------------------------QD
LRRKb_Spur      ----------------------------------------------------------KD
LRRKa_Spur      ----------------------------------------------------------DA
AqueK485_Aque   ----------------------------------------------------------SP
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ----------------------------------------------------------NT
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ----------------------------------------------------------RD
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ----------------------------------------------------------AN
AqueK494_Aque   ----------------------------------------------------------KK
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ---------------SSSL-VETKALTK----------------ELLGKEDKAKRHGEEQ
AqueK497_Aque   ----------------------------------------------------------VC
AqueK498_Aque   NVIEDLVSPMSTSSASSSVHFKPQAYVTEEGESKHRIPPSLQILPDIGEGEEREREGEED


LRRK2_Hsap      ----AS----IWLGCGH--TDRGQLSFL-D---LNT-E----------------------
LRRK1_Hsap      QEYTVV----F-WD-GK--EESRNY--T-V---VNT-E----------------------
CG5483_Dmel     ERCGLE----LWLPSFG--SR---I--D-I---LDC-S----------------------
LRRK2_Mmus      ----AT----LWLGCGN--TEKGQLSLF-D---LNT-E----------------------
LRRK1_Mmus      QEYTVV----F-WD-GK--EESRNY--T-V---VNT-E----------------------
T27C10.5_Cele   DDFEAQ----LWLSG----RE---M--V-V---MGC-T----------------------
GbpC_Ddis       RDNS------------------SL---V-SAS--SLGNNTSTSSLASLVSNNSGLHHSPS
Pats1_Ddis      SGSSYRNKSHDTISH-------STS-----------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     -GWNNSSKPH------------SKV--F-A---LNL-S----------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      SSGSYNTESY-SVAS-------S-------------------------------------
Roco5_Ddis      SGTTSPPQPH------------PQL--V-RKLTQNF-T----------------------
Roco6_Ddis      SSNS------------------SQN--I-ANK--SL-NNISATSLGDL------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      R---------------------GNT-----------------------------------
LRRKd_Spur      EDKVVH----LIVESGR--GTSVRS--F-Q---VD--E----------------------
LRRKc_Spur      EDKVVH----LVVDSGR--GTSVKS--F-Q---VD--E----------------------
LRRKb_Spur      DQERTE----IWLAGGE--KNSTMF--S-C---FTI-R----------------------
LRRKa_Spur      SSSLPV----IWMTQTVEEDQSSSV--V-I---LNI-D----------------------
AqueK485_Aque   -SSPYV----YWASG-S--RG---L--V-I---GNI-E----------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ---------------PVETDPEASI--AST---VSS------------------------
AqueK489_Aque   ----------LSIPG---------F--K-T---L--------------------------
AqueK490_Aque   TGEGSE----LLVEG-------TQV--F-I---LNA-T----------------------
AqueK491_Aque   ----------VSFRG-------RAN--F-V---V--------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ITGHTN----TWDT-----QNEE--HLY-N---IDV-R----------------------
AqueK494_Aque   HGVRTE----VWLTSCD-AGQQSML--S-V---INL------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   AY--SQ----IWMCGRD--QKKGLL--S-V---FIF-P----------------------
AqueK497_Aque   ENTQYL----LWTWSRQ--DTERNF--S-L---FNV------------------------
AqueK498_Aque   NHRFYQ----VWVVSSS--NHNSVA--T-V---VDY-C----------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------PSGSLLQ-CNSI
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------QYGFV-D-QKS-
GbpC_Ddis       ASDGLNDYYGADNNNNNNDSTMDFFQDIFTEEENEQPYPFADDDQQK---G-ILFGF--D
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------GGNDENLGGQLQY-S--M
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   -----------------------------------------------PDEGTLY--SKIL
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ---------------GYT--SE--EV----------------------------------
LRRK1_Hsap      ---------------KGL--ME---V----------------------------------
CG5483_Dmel     SCSPQPQVAPPKTPENGA--NSRARS----------------------------------
LRRK2_Mmus      ---------------RYS--YE--EV----------------------------------
LRRK1_Mmus      ---------------KGL--LE---V----------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       -EE-----------QT-------NPSASS-------------------------------
Pats1_Ddis      -----------------------------VASDLLDIDN-----TLTVATTPRN-----R
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ---------------S-------MLFEDKLMVVLNNKQSTTYKA-----FYTHM-----Q
Roco11_Ddis     ---------------------------------------------IN-------------
Roco4_Ddis      -----------------------------STTNLL---N-----TLNNANQPVNFIGTAS
Roco5_Ddis      ---------------P-------IATSPTPSVIVSSVPTTTTTTTTSVATTPTV-----Q
Roco6_Ddis      -RV------------P-------QPEAKV-------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------IYTLV-------------------------
LRRKd_Spur      ---------------DGC--YKSSLL----------------------------------
LRRKc_Spur      ---------------DGC--YKSSRL----------------------------------
LRRKb_Spur      ---------------NS---EQDASV----------------------------------
LRRKa_Spur      ---------------RTP--SDDTTC----------------------------------
AqueK485_Aque   AEAPRPE--------SGLFANRRGKP----------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   -----------------P--TSSV------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ---------------N-------LTVQ---------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ---------------EVL--MKQIGI----------------------------------
AqueK494_Aque   ----------------T---DKAAQP----------------------------------
AqueK495_Aque   -----------------------LM-----------------------------------
AqueK496_Aque   ---------------DRQ--KTSSR-----------------------------------
AqueK497_Aque   ----------------A---KGMFTL----------------------------------
AqueK498_Aque   ---------------GQF--MK---I----------------------------------


LRRK2_Hsap      -----------------------------A------------------------------
LRRK1_Hsap      -----------------------QRMC-CP------------------------------
CG5483_Dmel     ------------------------AQR-LP------------------------------
LRRK2_Mmus      -----------------------------A------------------------------
LRRK1_Mmus      -----------------------QRMT-CP------------------------------
T27C10.5_Cele   -------------------------IE-LP------------------------------
GbpC_Ddis       -----VSI--------IIAATMAKMIE-MMTKGESSATLKSEHISTRRRSDTAGKNGVPP
Pats1_Ddis      SKTNDDNIIN--------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     SE----------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      VHKKMEVLAGVEAGETVW------------------------------------------
Roco5_Ddis      TI----------------------------------------------------------
Roco6_Ddis      -----NQL--------V-------------------------------------------
Roco7_Ddis      NNFVIPIITAIANGGI--------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      -----------------------NELQ-CP------------------------------
LRRKc_Spur      -----------------------NELQ-CP------------------------------
LRRKb_Spur      -----------------------QGMI-IQ------------------------------
LRRKa_Spur      -----------------------FNLT-VT------------------------------
AqueK485_Aque   -----------------------IPIA-VG------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------NSS-YM------------------------------
AqueK489_Aque   -----------------------NNTS-LP------------------------------
AqueK490_Aque   -----------------------GSLE-LK------------------------------
AqueK491_Aque   -----------------------DSID-LE------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   -----------------------GDKS-AY------------------------------
AqueK494_Aque   -----------------------QGRMLPQ------------------------------
AqueK495_Aque   -----------------------RPTT-II------------------------------
AqueK496_Aque   -----------------------FFGY-IG------------------------------
AqueK497_Aque   -----------------------P-EKPSA------------------------------
AqueK498_Aque   -----------------------EDVD-LG------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       HWRNSVPLSTNSSTTLDETFIDDFIYVYRSFTTPRNIFKLLVRRFFGPRHTDKVDTFTIK
Pats1_Ddis      -------------------TSNGRIITN--------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     -------------------FNEENLMFY--------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      -----------------TKSADSSLCFW--------------------------------
Roco5_Ddis      -------------------LAGGNITPK--------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------GS----------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       KFEQKKAAIRQGIAVFLRKWVADITELEFRQEEFWLYHNTVAFTKQFIASEFPTIATQIY
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ----------------------------------W-------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       GTLTTHEDEVNLTNQRFLQIAFSESEIQIDR-AMS---------------SMQ-------
Pats1_Ddis      ------------------------------S-INNSNSNNEQPL--SPNSLLQHSQSQQQ
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------EAIK--------TFKSLP------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------S-TKKGHL----------------------
Roco5_Ddis      ------------------------------PSVP--------T-AMKP------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ----------------------------------------KRPI--T-------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       -------------LTTPKPFRSQKNLANSYNSQSGGGDSSFYYQP---------------
Pats1_Ddis      LENVGLSALLDALPNSPIVSSTA--------------------APSTTSTNKKVMYTSIV
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      --------------------------------------------E---------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      --------------------------D-SRILCLALV-----------------------
LRRK1_Hsap      --------------------------G-MKVSCQL-------------------------
CG5483_Dmel     --------------------------K-MNMLCCC-------------------------
LRRK2_Mmus      --------------------------D-SRILCLALV-----------------------
LRRK1_Mmus      --------------------------G-MKLSCQL-------------------------
T27C10.5_Cele   --------------------------H-R-GKYVS-------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      GDSARTRRGSVSIQPFQNEFNRELLPNQGTIQCLI-------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ----------------------NQTPDD--------------------------------
Roco11_Ddis     ----------------------DKSP----------------------------------
Roco4_Ddis      -------------------INELKCPHTVATTMMI-------------------------
Roco5_Ddis      ----------------------NITPKP--------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------GGNQHQQNGS-------STPHS------N-------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      --------------------------M-IRTAIAT-------------------------
LRRKc_Spur      --------------------------M-IKTAIAT-------------------------
LRRKb_Spur      --------------------------K-GRA-----------------------------
LRRKa_Spur      --------------------------G-GTVRCVC-------------------------
AqueK485_Aque   --------------------------H-ATAIDVC-------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   --------------------------S-PLLVCLA-LRQEESS-----------------
AqueK489_Aque   --------------------------A-QCIVCMA-------------------------
AqueK490_Aque   ----------------------------ERANAIC-------------------------
AqueK491_Aque   --------------------------C-APVTAMC-------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   --------------------------D-AIMTCM--------------------------
AqueK494_Aque   --------------------------N-TLV-----------------------------
AqueK495_Aque   --------------------------T-ETCLHMA-------------------------
AqueK496_Aque   --------------------------K-EEIQALC-------------------------
AqueK497_Aque   --------------------------G-GRV-----------FAMATTGEVDIFSFGMLL
AqueK498_Aque   --------------------------D-SPVLAIS-------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   FELITGQRPFESMSTGQEVNRAVIQRERPQVSEGNMEPSFPGMIELMEDCWRHLAADRPT
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      -------------------------------------H----------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      -------------------------------------H----------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      -----------------------------------LCM----------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ---VVVMCEAVGSYDSNKVVM-KMTPMLQKIQEPIVSL----------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   -----------------------------------YCM----------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ADEVVQRISAPGFLCRRHTVSRVQQHPLQKI-DTIYCQPVINESVCENTQYLLWTWSRQD
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ---------------------------------L-PVEKESWIVSGTQSGT------LLV
LRRK1_Hsap      -----------------------------------QVQRS--LWTATEDQK------IYI
CG5483_Dmel     -----------------------------------LVGEA--IWMGDVSGN------LHA
LRRK2_Mmus      ---------------------------------L-AAEKESWVVCGTQSGA------LLV
LRRK1_Mmus      -----------------------------------KVQSS--VWIATEDQK------IYI
T27C10.5_Cele   -----------------------------------KVRDS--VWSCDECGQ------VTV
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      --------------------------------KVGGNGCQ--VWAGTGNGF------IST
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      -----------------------------------KVGKY--IWEATNSNG------IYI
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      --------------------------------SQSNSGSS--SVYESGDGS------LS-
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      -----------------------------------PCGTK--IVVGTGGDC------VQL
LRRKc_Spur      -----------------------------------PCGTK--IVVGTVGDF------VQV
LRRKb_Spur      ---------------------------------V-AIGPNT-MLVGTQSCE------LVL
LRRKa_Spur      -----------------------------------SVADT--MWLGLNTGS------IVV
AqueK485_Aque   -----------------------------------TYTRQ--VWVGTENGL---MGSVYV
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ---------------------------------FSLPDRS--VFVGRSGSS------ILY
AqueK489_Aque   -----------------------------------CTREY--LWVSFQHNF------VRV
AqueK490_Aque   -----------------------------------TVDSK--VWVGMLEAC------IHV
AqueK491_Aque   -----------------------------------CVNEQ--VWLGAKDGC------ITL
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ---------------------------------T-PALDV--VWVGMATGH------ILL
AqueK494_Aque   -----------------------------------LIVDQDWILMGTNTGH------VIV
AqueK495_Aque   -----------------------------------IVWNK--LFLVTSSKR------VYC
AqueK496_Aque   -----------------------------------PVRNA--MWVGTSLGN------LRV
AqueK497_Aque   TERNFSLFNVAKGMFTLPEKPSAGGRVFAMATTG-EVERRLW--VATSVARNFPDFEIQV
AqueK498_Aque   -----------------------------------MVHDK--VWIGFEIGY------LCI


LRRK2_Hsap      INTED-GK-KR--------------HTLEKMTD---SVTC-----------LYCNSF---
LRRK1_Hsap      YTLKG-MC-PL------N-----TPQQALDTPA---VVTC-----------FL--AV---
CG5483_Dmel     YSTST-YA-HL------F-----SYMLDPNIKS---AVIS-----------LV--YM---
LRRK2_Mmus      INVEE-ET-KR--------------HTLEKMTD---SVTC-----------LHCNSL---
LRRK1_Mmus      YSLKG-MC-PL------S-----VPQQALDTPA---VVTC-----------FL--AV---
T27C10.5_Cele   YGISL-HE---------T-----GHLQLPSLNG---TLIC-----------AP--EL---
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      WKIEGQEK-Y--------IQRL----FEANKDK---K---RIH--------C--LY----
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     --------------------------------R---E---IIK-----------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      WDMGT-MT-I--------VQQL----TTPHKGD---V---CLH--------FV-EY----
Roco5_Ddis      --------------------------------T---L---I-------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      SAG--SFKIL------RY--EM----VLPVAFT---S---TIH--------S--LYP---
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ---------PIQQQQQQKQ-----------------------------------------
LRRKd_Spur      YHLPS-SH-SS------HA-SLLVEARVAGQPT---SL-H-----------YI--QK---
LRRKc_Spur      YHLPS-SQ-SS------HA-SLLVEARVAGQPT---SL-L-----------YL--QK---
LRRKb_Spur      INLTS-SP-------------YQVKHTLPQLPD---AVLC-----------LS--WH---
LRRKa_Spur      YENGR-FS-YP---------NEIARLSLPQYKSKPRSPCT-----------ML--HI---
AqueK485_Aque   FNLPD-FK-SH-------------H--YIHLQD---AVLS-----------LK--IMNST
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   IHGNE-PP-L------------------------PLTICE--RCQNGKVMFIR--YF---
AqueK489_Aque   YSASS-LE-FI--------KEL----TF---DA---H---VLV--------MA-------
AqueK490_Aque   YDSTS-FN-F--------TDRV----FV---KD---S---V-----------T-------
AqueK491_Aque   YSAIN-HD-KS------FSRYL----SL-KADQ---G---IIH--------IS--HL---
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   FHEQE-LI-MH------F-------HPYTQYLR---FLIV-----------VPCE-----
AqueK494_Aque   SEGNG-ST-EGG-----GTERNRKEHKLAKLED---SVLC-----------FC--YV---
AqueK495_Aque   YSLPD-FT-LL------S-----SSKE--PLPA---QSSC-----------LF--VS---
AqueK496_Aque   IHAPS-LA-VK------F-----SGNL--SSDD---QSSAILK--------IL--HI---
AqueK497_Aque   FSYKN-A-----------VEPPVYLW-SFIVRD---SVLD-----------MT--TV---
AqueK498_Aque   YDADT-HN-TL------A--QVW-----IRRGI---AVQ----------------SI---


LRRK2_Hsap      ------SKQSKQKNFLLVGTAD-G----KLAIFEDKTVKL----KGA-----AP-LKI--
LRRK1_Hsap      ------PVIKKNSYLVLAGLAD-G----LVAVFPVVRGTP----KDS-------------
CG5483_Dmel     ---------E-KIARVAVGTHN-G----RVFLVDATQMPS----NC------AFAEG---
LRRK2_Mmus      ------AKQSKQSNFLLVGTAD-G----NLMIFEDKAVKC----KGA-----AP-LKT--
LRRK1_Mmus      ------PVIKKNSFLVLAGLAD-G----LVAVFPVARGTP----KES-------------
T27C10.5_Cele   ---------ISNDVLIL--ISD-K----QIVLLKLSESN----------------SV---
GbpC_Ddis       ------S--SNDVSRVFLNLAT-GMRDPLLGITVKEKK---FKK----------------
Pats1_Ddis      ----------PYMNTVWCGSAD-D----SITIWDIDTY---QK-IKS-----YSV-----
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     -------IQSKKIYQVFIGENA-PK---EINLPFLLKK---EL-KNK-----IDF-----
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ----------GDNNGVWSGGSE-G----TVCLWDMQTF---EK-KHS-----FS------
Roco5_Ddis      ------------------SSQKPPA---PNPVPILK-T---PT-PTNLSPTSIST-----
Roco6_Ddis      ------V----NSRRVWGGCES-G----EIIVWNAENG---NQIFRE-----QKL-----
Roco7_Ddis      ------VQNNKNEVFVWCGMGD-G----SVCVINSATR---QI-VST-----SRI-----
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------PSGQ-EHSLLFVGQAN-G----VLTVLSHETEDS----GHH-----ITDDLKLV
LRRKc_Spur      ------PSGQ-ERSLLFVGQAN-G----ALTILSHETEDS----GHH-----TTDDLRLV
LRRKb_Spur      -------TKRREDGKVFAGLAN-G----TIAVYSAKRIRL----EKD-----CKPDQY--
LRRKa_Spur      ----------PPLQLVAIA-AD-H----EVAFRQEDGNGM----PSA-----D-SDGF--
AqueK485_Aque   PPPPPSSSQSEYDYKALVGLAN-G----TIIIFSGRNQER----LLE-----NPLQG--P
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ----------QKDQIFVCGFSN-G----AVHTSHTSQRDM----KKP-----D-SLIG--
AqueK489_Aque   ----------VSPDCVYLGKED-G----EIQVFNLSQP---SPLHGA-----Y-R-----
AqueK490_Aque   -------DIATNDKYAFVGLAN-G----TLTYYDKLKF---PS-VSG-----D-------
AqueK491_Aque   ----------TKLRQVLVVRKD-G----YLMLLDEVLSERRIPDTSH-----F-D-----
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------GPCEKEK-CMMASGAK-G----F-----------------Q-----SP-LEG--
AqueK494_Aque   ------KRRYEGKSYVFMGLAN-G----HLVAFDSQSIKT----PNA-----S-PEVD--
AqueK495_Aque   ------CDA-SMVAVGMEGGAG-G----RIALFTASSEEG----GAS-----ALATPPL-
AqueK496_Aque   ------EEK-NCILVSST---C-S----EVWCL----------------------HDKL-
AqueK497_Aque   ------V-EGGRVKRVFASLAN-G----TICVFSRVSISS----PQP-----S-EVGD--
AqueK498_Aque   ------AHIP-QLSQVYVGLAN-G----TILSYSDIITPI----SND-----DDS-----


LRRK2_Hsap      --LNIG------------------------------------------------------
LRRK1_Hsap      -------------------CSY--------------------------------------
CG5483_Dmel     SFV-LT------------------------------------------------------
LRRK2_Mmus      --LHIG------------------------------------------------------
LRRK1_Mmus      -------------------CSY--------------------------------------
T27C10.5_Cele   SH--LG------------------------------------------------------
GbpC_Ddis       ---------------DK--VSTLCCSG-SEIIDWITKCMPIKREEASILVLDMLMKQFFI
Pats1_Ddis      -------------EG-PSC-----------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------PDG-PS------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      --PTTP-TTPTTPTT-PT------------------------------------------
Roco6_Ddis      -------------HPGP--IRSLALVNQEDI--WS-------------------------
Roco7_Ddis      -------------AD-SSRILGFSLIRK--------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      TRMQLS-K-----HNL--PCSS--------------------------------------
LRRKc_Spur      TRMQLS-K-----HNL--PCSS--------------------------------------
LRRKb_Spur      --IQVG-T-----Y----------------------------------------------
LRRKa_Spur      --HYVHVQ-----R----------------------------------------------
AqueK485_Aque   RRV-VT------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   --SYCGES-----K----------------------------------------------
AqueK489_Aque   --TRVI-S-----YQK--PIKSL-------------------------------------
AqueK490_Aque   --IEIG--------SK--ALISM-------------------------------------
AqueK491_Aque   --AHVN-A-----TQL--PVRCV-------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   --YPLD------------------------------------------------------
AqueK494_Aque   --ILLN------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   --AQVI-P-----E----ACVL--------------------------------------
AqueK498_Aque   -------------------VPL--------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       QISDDGIPISNQKGTNPTFSDSPTSFYMFLEDDPELIARQYTFLELKYLQNIHPRELL--
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ---------------------------------------------------------AGG
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       -GFSVGLVMPNENEKDPEKWRQSNFPHIYDYFRWFNKMTMLVSTEILRQRDIKQRASIIE
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      IGPQQS------------------------------------------------------
Roco7_Ddis      CTPSS--------------------------------------SSVTL------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       KYISIALEYLSLWN-----------------------------------------FNGIM
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      --------TIRIWNAWRFNLDDQSGTKSDFITKKGRGGSTFGRKSWRLRWFVLSRFDKTL
Roco7_Ddis      ------------TSRSSLN------------------LSSLASGSTPSPY-SSGGSGGSL
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      --------------------------------------NVSTPL----------------
LRRK1_Hsap      --------------------------------------------LCSHTANRSKFSIA--
CG5483_Dmel     --------------------------------------EICSGF----------------
LRRK2_Mmus      --------------------------------------DVSTPL----------------
LRRK1_Mmus      --------------------------------------------LCSHTANRSKFCIP--
T27C10.5_Cele   --------------------------------------TIDSPY----------------
GbpC_Ddis       QVLSSLHSEPISRLSATWAKVSQRSMDCFYE-----------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      KYYSK--------------QTDKE-PSCSLILEGAWLEEISPPG----------------
Roco7_Ddis      G-------------------SSYQ-PICPTI-----------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      --------------------------------------------IVAVSRKKNGDSMAEQ
LRRKc_Spur      --------------------------------------------IVAVYRKKNGDSVAER
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------EI----------------
AqueK485_Aque   ------------------------------------------TF----------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------SIK---------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   -------------------------------------FNLKTPL----------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   --------------------------------------DFPQTE----------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   --------------------------KCEDDKYRTEAEDWGQPLI---------------
AqueK498_Aque   --------------------------------------------IATHLTPLSTYKEP--


LRRK2_Hsap      ------------------------------------------MCL---------------
LRRK1_Hsap      ------------------------DEDAR-QN------PYPVKAM---------------
CG5483_Dmel     -----------------------------VL-------HAACSV----------------
LRRK2_Mmus      ------------------------------------------MCL---------------
LRRK1_Mmus      ------------------------DEDAR-QN------PYPVKAM---------------
T27C10.5_Cele   -----------------------------EI--------RTATF----------------
GbpC_Ddis       ---------------------------------------------LSRLMLPESNYLPLR
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------YKVSLHLIHPEK------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      RRRYEEVVYNGANGVWNRSAKSNGTREER-RD------ETTARKM---------------
LRRKc_Spur      RRQYEDVVSNGANGSRDRSVQSNGT------D------ETTARKM---------------
LRRKb_Spur      --------------------------------------HEPIKCS---------------
LRRKa_Spur      ------------------------------IS-------MAIVLK---------------
AqueK485_Aque   -----------------------------N--------RKPCLG----------------
AqueK486_Aque   --------------------------------------------R---------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------GA-------TAYQII---------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------SSV---------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------EDR---------------
AqueK494_Aque   --------------------------------------RGPIKGM---------------
AqueK495_Aque   -----------------------------IMK------PFDHLNK---------------
AqueK496_Aque   -----------------------------IGK------PYSIVKE---------------
AqueK497_Aque   ------------------------------LTLSEAAKGMSIKYM---------------
AqueK498_Aque   ------------------------NEICPVIL------PIMVKPW---------------


LRRK2_Hsap      -----------------------------------------S-----------------E
LRRK1_Hsap      -----------------------------------------E------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      -----------------------------------------S-----------------E
LRRK1_Mmus      -----------------------------------------E------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       TALASQKPNTIIQASPLYPNISAYMVHTVCPTIPFLGALIAD-----------------L
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      -------------------------------------RTMEM-----------------E
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      -----------------------------------------R-------GGRNSLEPRER
LRRKc_Spur      -----------------------------------------R-------KGRNTLVTRER
LRRKb_Spur      -----------------------------------------Y------------------
LRRKa_Spur      -----------------------------------------K------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   -----------------------------------------Y------------------
AqueK489_Aque   -----------------------------------------Q-----------------V
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   -----------------------------------------L-----------------T
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   -----------------------------------------S-----------------Q
AqueK494_Aque   -----------------------------------------K------------------
AqueK495_Aque   -----------------------------------------RRG----Q-----------
AqueK496_Aque   -----------------------------------------QRIQTNEREGSG-------
AqueK497_Aque   -----------------------------------------T------------------
AqueK498_Aque   ----------------------------------------------------------NE


LRRK2_Hsap      S---TN----STERNVMWGGC-GTK----------------IFSF--S-NDF-TI-Q-KL
LRRK1_Hsap      -----V----VNSGSEVWYSN-GPG----------------LLVI--DCASL-EI-CR-R
CG5483_Dmel     ----VV-----DGIYELWCGE-IAGK---------------INVF--PLNEN-GVSGHQA
LRRK2_Mmus      S---LN----SSERHITWGGC-GTK----------------VFSF--S-NDF-TI-Q-KL
LRRK1_Mmus      -----V----VNSGSEVWYSN-GPG----------------LLVI--DCTIL-DI-SR-R
T27C10.5_Cele   ----LG----NGSTRQIWAGH-SEGR---------------ISIH--HIASNDSFSFSSS
GbpC_Ddis       S---Q-----TCTENPTFISSGGEKMINI---------------LRV--KRL-SK--K-M
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ----------------------------------------------VTVFN---------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ----------------------------------------------TPT-----------
Roco6_Ddis      F---K-----SESEKSSWLTA-INRVIN----------------QNIPLYEI-AL-GK-Q
Roco7_Ddis      -----------EEDSHIWAFY-NE---------------------GILCFEA-KS-FK-L
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      TGGSRD----EADGTEVWVGC-GNK----------------LRII--LLDDI-TL-EPDG
LRRKc_Spur      TGSSGD----EADGTEVWVGC-GNK----------------LRII--SLSDI-TL-EPDE
LRRKb_Spur      -----L------TNSRLWVGV-GDRV----------------EAI--TLKTL-KS-EI-K
LRRKa_Spur      ----NG----SKRSYELWCGQ-TEGYI---------------TVL--DAGNL-TL-CQ-V
AqueK485_Aque   ----IN----AGTDGHLWTAC-GDN----------------FEVF--EFPAM-K-SVRRN
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   -----R----EGENFEVWCGS-KDSFI---------------EVSTFNVTNV-KA-RR-V
AqueK489_Aque   L------------DDCIICCT-KNSFYR------------------VHPNTL-HV-LQ-E
AqueK490_Aque   ----------LSVGECLWVVC-GNEIIV----------------LCVDDDDI-TI-AK-R
AqueK491_Aque   L---SS----NEETAYTWISS-SNEVVTV---------------LEIRTSVI-SH-CQ-K
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   S---LD----DSGVMILWEAYSGAT----------------L-----------RQ-M-KI
AqueK494_Aque   -----R----L--HDRLYVIS-ELQV----------------FVI--SLKEL-KV-LF-K
AqueK495_Aque   -VSSGC----FCGDSKILCGS-GR----------------YLFGL--SLPKM-KQ-VF--
AqueK496_Aque   -PVYDLVKVVIDGQLQVWGTM-DNNTIILFEKKEGAWQTSYYDVI--PYSHH-MK-V---
AqueK497_Aque   -----F----V-GKDFLWCGC-GNSI----------------SVI--NVVEM-KV-VT-S
AqueK498_Aque   EEGREE----EGIAFHLWVGQ-KNKS---------------ITVL--NAEDL-SI-VD-F


LRRK2_Hsap      IET------------------R----------TS-----QLFSYAA-FSDS-NIIT----
LRRK1_Hsap      LEPYM-------------------------------------------A-P-SMVT----
CG5483_Dmel     LCH------------------------------------------S--EEP-NLIE----
LRRK2_Mmus      IET------------------K----------TN-----QLFSYAA-FSDS-NIIA----
LRRK1_Mmus      LEPYA-------------------------------------------A-P-SMVT----
T27C10.5_Cele   LYL------------------------------------------P--DDK-CIVR----
GbpC_Ddis       KMF--------------------------------------------KEYK-EMPTQYLP
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      MTS--------------------------------------------GSEN-DYIT----
Roco7_Ddis      LK---------------------------------------------TIKT-NFIT----
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      IQVAA-------------------------------------------GME-GIIE----
LRRKc_Spur      IQVAA-------------------------------------------GVE-GIVE----
LRRKb_Spur      LE------------------HD----------K------K---ETSKDPRK-LGLV----
LRRKa_Spur      ILC-----------------HL----------E------D---PLPLAPVT-QMVT----
AqueK485_Aque   VCS------------------Y----------SNG---GG---G-A--SAS-SVKG----
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   QSL-----------------SL----------K------H---KT-FTVPS-SLVS----
AqueK489_Aque   F--L-------LIS-------------------------------E-TGV----KS----
AqueK490_Aque   LNAA-------------------------------------------SSNH-QVYA----
AqueK491_Aque   LQAR-------SYS-------------------------------E-TNKT-DILS----
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   IEK------------------ESPGYLDNHKTVA-----RMIKKLQ-FKDDTHIVK----
AqueK494_Aque   W--------------------------------------V---ACE-DSSR-KFLT----
AqueK495_Aque   ------------------VHTL----------SDRGGEKG---GAK-GDEE-SVIE----
AqueK496_Aque   -----------------------------------CSHIV---WCS--------FE----
AqueK497_Aque   I--------------------------------------P---VFT-R-RA-QLIN----
AqueK498_Aque   LDTPDDTTPCPSYLDQVPFYYL----------TSS---VS-------PKDS-EDSE----


LRRK2_Hsap      --------------V--------V-VD---------------------------------
LRRK1_Hsap      --------------SVVCSS-EGR-GE---------------------------------
CG5483_Dmel     --------------DVKVAR-MCS-NE---------------------------------
LRRK2_Mmus      --------------L--------A-VD---------------------------------
LRRK1_Mmus      --------------SLVCSS-DCR-GE---------------------------------
T27C10.5_Cele   --------------QLV----GSK-DA---------------------------------
GbpC_Ddis       ALTTIPLQYYEHYVN-----D-LK-ALDSLQIDRLSDIERKLEIICEKNGTTNDDKEKGD
Pats1_Ddis      --------------------I-TR-VG---------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     -----------------------D-TL---------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      --------------N-----L-LS-VG---------------------------------
Roco7_Ddis      --------------S-----L-VD-EG---------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      --------------GIV------Q-SQ---------------------------------
LRRKc_Spur      --------------GIV------H-SQ---------------------------------
LRRKb_Spur      --------------K-T-----VA-LE---------------------------------
LRRKa_Spur      --------------YDLAIQ-EQM-GL---------------------------------
AqueK485_Aque   --------------EV-IIY-SGL-NR---------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   --------------WM-CLT-SD---E---------------------------------
AqueK489_Aque   --------------AVVALD-RMN-NN---------------------------------
AqueK490_Aque   --------------L-----VLSE-RN---------------------------------
AqueK491_Aque   --------------HMTCVKLGGRDER---------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   --------------D--------L-TA---------------------------------
AqueK494_Aque   --------------C-I-----EA-ND---------------------------------
AqueK495_Aque   --------------GM------VL-YG---------------------------------
AqueK496_Aque   --------------EE------GT-QC---------------------------------
AqueK497_Aque   --------------E-L-----VS-DG---------------------------------
AqueK498_Aque   --------------SILLRE-DAL-EP---------------------------------


LRRK2_Hsap      --------------------TALYIA----KQN-S-PVVEVWD-----K-----------
LRRK1_Hsap      --------------------EVVWCL----DDK-A-NSLVMYH-----S-----------
CG5483_Dmel     --------------------SHVFSC----LYP-G-CMVYQWD-----V-----------
LRRK2_Mmus      --------------------TALYIA----KKN-S-PVVEVWD-----K-----------
LRRK1_Mmus      --------------------EMVWCL----DDK-A-NCLVMYH-----S-----------
T27C10.5_Cele   --------------------QKVWIA----LEK-S-SKVQMVE-----V-----------
GbpC_Ddis       ENGGGLTSSNFFGNGSDELTERDWTI----LLT-N-ASVIAYN-----RGDVVMEENAIN
Pats1_Ddis      --------------------NTMWVG----T--IV-NTIHIYD-----L-----------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ---------------------TFVIS----S--IE-DSFHRFKF----------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      -------------------------N----S--TS-SN-----LKPTPT-----------
Roco6_Ddis      --------------------PNVWVS----LKE-T-PSILVYN-----V-----------
Roco7_Ddis      --------------------ESVWSN----CKEKT-SCIKVIS-----K-----------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      --------------------GSVWCF----TSS-A-LYVYQYS-----T-----------
LRRKc_Spur      --------------------GSVWCF----TSS-A-LYVYQYS-----I-----------
LRRKb_Spur      --------------------KCLWLC----RHN-S-GVIEVWN-----T-----------
LRRKa_Spur      --------------------QHVWSY----VQP-G-PVVYKWN-----T-----------
AqueK485_Aque   --------------------QGVWSV----ARR-S-AVLRLWD-----I-----------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   --------------------TMMFVVLEDSLRP-GACCLCRVG-----V-----------
AqueK489_Aque   --------------------EYLWVC----FRR-L-QELVVFN-----C-----------
AqueK490_Aque   --------------------SLVWCF----IKT-S-LVLICWD-----A-----------
AqueK491_Aque   --------------------SVVCGF----SYP-G-CVLYIWE-----S-----------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   --------------------TT-TDE----SES-S-PSVPIDD-----T-----------
AqueK494_Aque   --------------------SFVWTS----YHN-G-PFIQAWD-----I-----------
AqueK495_Aque   --------------------RYLWVW----FSD-H-GEIVLCD-----V-----------
AqueK496_Aque   --------------------DYLWVS----YRS-K-AGIVCFD-----A-----------
AqueK497_Aque   --------------------NKVWGI----GRQ-L-ANVIEWD-----A-----------
AqueK498_Aque   --------------------VWVYGA----LRH-G-QFVTVWD-----G-----------


LRRK2_Hsap      ----------------KTEK-L--------------------------------------
LRRK1_Hsap      ----------------TTYQ-L--------------------------------------
CG5483_Dmel     ----------------ISKR-I--------------------------------------
LRRK2_Mmus      ----------------KTEK-L--------------------------------------
LRRK1_Mmus      ----------------ATYQ-L--------------------------------------
T27C10.5_Cele   ----------------EKRQ-V--------------------------------------
GbpC_Ddis       THLYRIKSGAISVEKKDKEG-I--------------------------------------
Pats1_Ddis      -------------------KKK--------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ----------------SKSN-PSSPPQIATTATATQTPTPSPISVLKPPRSLPQKPVGTT
Roco6_Ddis      ----------------KSKE-L--------------------------------------
Roco7_Ddis      ----------------SKLK-T--------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ----------------ETRS-C--------------------------------------
LRRKc_Spur      ----------------ETRK-C--------------------------------------
LRRKb_Spur      ----------------GKQQ-L--------------------------------------
LRRKa_Spur      ----------------ETRA-I--------------------------------------
AqueK485_Aque   ----------------KNGE-L--------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ----------------VDKE-V--------------------------------------
AqueK489_Aque   ----------------VKGK-A--------------------------------------
AqueK490_Aque   ----------------SSCA-Q--------------------------------------
AqueK491_Aque   ----------------SNNH----------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ----------------R-ET-L--------------------------------------
AqueK494_Aque   ----------------EDGS-H--------------------------------------
AqueK495_Aque   ----------------ETGE-K--------------------------------------
AqueK496_Aque   ----------------RTRT-Q--------------------------------------
AqueK497_Aque   ----------------KTYT-I--------------------------------------
AqueK498_Aque   ----------------ASRK-I--------------------------------------


LRRK2_Hsap      ---------C----------------------GL---ID-C----------------V--
LRRK1_Hsap      ---------C----------------------AR---YF-C----------------G--
CG5483_Dmel     ---------E----------------------NK---LD-C----------------S--
LRRK2_Mmus      ---------C----------------------EL---ID-C----------------V--
LRRK1_Mmus      ---------C----------------------AR---YF-C----------------G--
T27C10.5_Cele   ---------T----------------------GS---LD-I----------------R--
GbpC_Ddis       --------------------------------------N-CKVATMFAPKMFGEMSFL--
Pats1_Ddis      ---------T----------------------KYKGKIS-L----------------D--
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ---TVPTTNK----------------------NGWVEIE-C----------------K--
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ----------------------------------------L----------------E--
Roco5_Ddis      QTTSTPPTNQ----------------------TPNPTIVTR----------------PPL
Roco6_Ddis      ---------V----------------------TK---IS-L----------------N--
Roco7_Ddis      ---------K----------------------KLMNVKT-L----------------D--
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ---------L----------------------AI---LD-C----------------R--
LRRKc_Spur      ---------L----------------------AI---LD-C----------------R--
LRRKb_Spur      ---------K----------------------TT---ID-I----------------R--
LRRKa_Spur      ---------E----------------------GR---ID-F----------------V--
AqueK485_Aque   ---------K----------------------AS---FN-V----------------R--
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ---------S----------------------G---------------------------
AqueK489_Aque   ---------I----------------------YG---VN-C----------------S--
AqueK490_Aque   ---------A----------------------GS---ID-L----------------T--
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ---------KPFEMSYAPNDHSPDPRSSVMSYAR---SE-S----------------G--
AqueK494_Aque   ---------S----------------------MN---IN-V----------------F--
AqueK495_Aque   ---------L----------------------NS---IE-L----------------E--
AqueK496_Aque   ---------R----------------------GH---IN-C----------------S--
AqueK497_Aque   ---------N----------------------CV---FD-C----------------S--
AqueK498_Aque   ---------K----------------------TC---FN-V----------------L--


LRRK2_Hsap      -HF-------LREV----------------------------------------------
LRRK1_Hsap      -VP-------SPLRDMFPVRPLDTEPPAASHTANPKVPEGDSIADVSIMYSEELGTQILI
CG5483_Dmel     -KL-------LPCS----------------------------------------------
LRRK2_Mmus      -HF-------LKEV----------------------------------------------
LRRK1_Mmus      -DP-------NPLRDTFSVQPSVLETPG-SHKTTSKGPVEECIADVSIMYSEELGTQILT
T27C10.5_Cele   -KV-------MPGS----------------------------------------------
GbpC_Ddis       -GN---------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      PSS---------------------------------------------------------
Roco6_Ddis      -DD---------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      -ES-------ILVPGSF--LPL---------------------------YQEKRQELVRS
LRRKc_Spur      -ES-------ILVLGSF--LPL---------------------------SQEERQELVRS
LRRKb_Spur      -DL-------IGEQY---------------------------------------------
LRRKa_Spur      -AT-------ISTCR---------------------------------------------
AqueK485_Aque   -NI-------LKGE----------------------------------------------
AqueK486_Aque   -----------MQE----------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   -QV---------------------------------------------------------
AqueK490_Aque   -NT---------------------------------------------------------
AqueK491_Aque   -KL---------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   -KDVPLDKPSFRSL----------------------------------------------
AqueK494_Aque   -TS-------LAKQN---------------------------------------------
AqueK495_Aque   -VL---------------------------------------------------------
AqueK496_Aque   -DR---------------------------------------------------------
AqueK497_Aque   -RV-------DPTGNILIG-----------------------------------------
AqueK498_Aque   -DL---------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      HQESLTD---------YC------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      HQDSLTD---------YC------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      WEEKREKEQELASAT---------------------------------------------
LRRKc_Spur      WEEK-EKEQELASATAVCETNSNGDGRFVSNQDALLQEELPIVDN---------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ---------------------------------------VPSIEEFILPDSMISTIPKDS
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ---------------SMSSYSSSPPRQA--------ARSPSSLPSSPASSSSVPFSTDCE
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ---------------SMSSYSSSPPHQD--------PRSPSSLPSSLTSYSSVPFSANYE
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ---------------HFTAACIAPPRRG--------TTTRR-------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ERKSPSGSPQDQLESSTSSFTSGSPHNDSGFEVSNEPENPSKM----------PYATYNA
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------M--VKE--NK--------------------------------------
LRRK1_Hsap      DSDMLHTPGAA---SDRSE-----------------------HDLTPM------------
CG5483_Dmel     ------------ES--LQ--SI------------------------AI------------
LRRK2_Mmus      ------------M--VKL--NK--------------------------------------
LRRK1_Mmus      DSDRLQEPSVT---SDRTE-----------------------HDLSPM------------
T27C10.5_Cele   ------------ET--IH--TI------------------------DM------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ----LGGKRLG---GQRGKN------------------GMQRWNIHSI------------
LRRKb_Spur      ---------------PDA------------------------------------------
LRRKa_Spur      -----------SNPRPRG--RQ------------------------SH------------
AqueK485_Aque   ------------F-----------------------------------------------
AqueK486_Aque   ------------M--LKG--DV--------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------P--EPI--EN-------------------------PDTSKTHTEGCPF
AqueK494_Aque   ---------------PQG--SL------------------------AI------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   RFSRRTLRGIKP---RERTHNMSKQEGRGIFAPRPEFDALQKAKMRSI------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      -----------ESKHK---MS------------YSGRV----------------------
LRRK1_Hsap      ---------DGE---T---FS------------QHLQA----------------------
CG5483_Dmel     ------------DEHV---NL------------IKCQI----------------------
LRRK2_Mmus      -----------ESKHQ---LS------------YSGRV----------------------
LRRK1_Mmus      ---------DGE---T---FS------------QHLQA----------------------
T27C10.5_Cele   ------------EMAS---QN------------YVTCI----------------------
GbpC_Ddis       ---------KTT----ARL-T------------VDEESDLYVMDIPFLNNLFNGHPRLGA
Pats1_Ddis      -----------------------------------SPI----------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     -----------------------------------GIP----------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      -----------------------------------SAI----------------------
Roco5_Ddis      ---------LSS----NSI-NKPPSKPLPTPGGVTSPP----------------------
Roco6_Ddis      ---------QSS----DQW-G------------KTGAV----------------------
Roco7_Ddis      -----------------------------------AQI----------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ---------LAS---Q---SQ------------SSIKV----------------------
LRRKb_Spur      -------------------RI------------SEFDV----------------------
LRRKa_Spur      ------------R-PM---SA------------FRSQV----------------------
AqueK485_Aque   -----------------------------------NEI----------------------
AqueK486_Aque   -----------EDEPT---TV------------HRSRA----------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ---------------Y---WT------------FGIEI----------------------
AqueK489_Aque   ---------IGKDRAE---V----------------WI----------------------
AqueK490_Aque   ---------LTGICSQAGLES------------NNLRL----------------------
AqueK491_Aque   ---------LASHKYD---QF------------TTDKV----------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   SYIVDAKQMQGGDEPT---TV------------HHSRA----------------------
AqueK494_Aque   ------------E-G----GV------------YNSRV----------------------
AqueK495_Aque   ---------LGDSIPS---KE------------TSSRVL---------------------
AqueK496_Aque   ---------IKGK-DD---FD------------TSHQV----------------------
AqueK497_Aque   ------------L-R----QQ------------GATRV----------------------
AqueK498_Aque   ---------LPHW--K---ED------------AMPSV----------------------


LRRK2_Hsap      ---------------------------------------KTLCL-------QKNTA--LW
LRRK1_Hsap      ---------------------------------------VKIL--------AVRDL--IW
CG5483_Dmel     ---------------------------------------SALA--------AHNSE--LY
LRRK2_Mmus      ---------------------------------------KALCL-------QKNTA--LW
LRRK1_Mmus      ---------------------------------------VKVL--------AVKDL--IW
T27C10.5_Cele   ---------------------------------------GLLE-R------NDGDQ--LY
GbpC_Ddis       KFYKIMANQLAIRLKNLPWSKPKNTTGGSSSSNQSAGPDN--------I-LGTTPT--GI
Pats1_Ddis      ---------------------------------------ECL--------LRRDQE--VW
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ---------------------------------------PLPMVGHSS-ILWNNSL--IV
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ---------------------------------------TAMS-------YFGNNT--LY
Roco5_Ddis      ---------------------------------------PPPTTSSTT-PIKFNSI----
Roco6_Ddis      ---------------------------------------N--------M-MLVNNF--VW
Roco7_Ddis      ---------------------------------------TTILIHHSSVGAVGASR--VW
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ---------------------------------------SSLL--------VMDHV--LW
LRRKb_Spur      ---------------------------------------KSMMLQ-------PRTA--LW
LRRKa_Spur      ---------------------------------------NSMCL--------SGEY--LY
AqueK485_Aque   ---------------------------------------TALV--------VRGHA--VW
AqueK486_Aque   ---------------------------------------RSYAI-------TNETFDIDI
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ---------------------------------------SHFSI--------TTAD--LL
AqueK489_Aque   ---------------------------------------TC-------I-QVVLDT--VW
AqueK490_Aque   ---------------------------------------LS-------L-ECCQDI--IW
AqueK491_Aque   ---------------------------------------TD-------V-MSMGSM--LY
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ---------------------------------------GRYAL-------TNETFDIDI
AqueK494_Aque   ---------------------------------------TAMYLY---N-SGNKSF--LW
AqueK495_Aque   ---------------------------------------PALV-K------PTPHA--MW
AqueK496_Aque   ---------------------------------------ISLL--------AQGRR--LY
AqueK497_Aque   ---------------------------------------TSLLL--------VHDT--LW
AqueK498_Aque   ---------------------------------------SALY--------CSSSY--MY


LRRK2_Hsap      IGTGGGHILLLDLST--R-RL-I--RV------------------IYNFC-N--SV----
LRRK1_Hsap      VPRRGGDVIVIGLEK--D-SGA--------------------------QR-G--RV----
CG5483_Dmel     IGTTWGCLIVAELHT--L-RP-I--SV------------------FRPYE-N--EI----
LRRK2_Mmus      IGTGGGHILLLDLST--R-RV-I--RT------------------IHNFC-D--SV----
LRRK1_Mmus      VPRHGGDIIVIGLEK--D-SGA--------------------------QR-G--RV----
T27C10.5_Cele   IGTSKGLLVIAHATT--L-QP-L--SA------------------CRPFE-G--DI----
GbpC_Ddis       SSSG-GGLTSLLNQ-N-LSSI-M--SL--------SN---------SNTPPA--SPRVMT
Pats1_Ddis      VATL-GNIARIDVN-S-L-RV-V--QM--------T----------KAHE-R--A-----
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     IGGWFNKARLLNQI-H-I-LN-L--ET--------F----------E-------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      IASG-SHIVVFKTK-T-L-LM-NVNQN--------W----------KHST-G--S-----
Roco5_Ddis      ----SAGNKTIGQS-S-T-LP-S--ST---------------------------------
Roco6_Ddis      ITGG-SKLTQIDSQ-S-Y-QL-L--EV--------H----------GNHY-S--KP----
Roco7_Ddis      LGTDRGMIFILEYP-S-M-AP-I--AH--------H----------ESHG-G--AL----
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      -------------------------------------------------A----------
LRRKc_Spur      IGRSNGDIVLVNIQD--N-VGSF-EEK--------M----------DVQV-G--EV----
LRRKb_Spur      VGTAAGKLVLIDVNT--Y-QL-I--TV--------I----------GRHV-S--GL----
LRRKa_Spur      IGISCGHLLVLDAST--L-AP-A--IL--------L----------SCHE-G--PV----
AqueK485_Aque   LGTRSGYLFLLDASA--I-EN-Q--EQETAIKGFQ-YCGDGRVKGITPFP-S--SL----
AqueK486_Aque   QGTCQGQLLRISCPK--P-VL-L--QT------------------LLSK-----------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   LGTVTGEVLIVPMSR--L-QK-N--QN--------YFDASAAVMSIPSHK-G--SV----
AqueK489_Aque   VGLNTGHILTFSAYSLTP-LL-L--TY--------F----------KPHK-E--NI----
AqueK490_Aque   VGVSVGIIVLLTATPT-P-RV-I--TW--------F----------RAHR-S--SP----
AqueK491_Aque   MSTGGGEVVTLSLSNS-L-QE-I--SS----PLFPI----------SAHS-KSRGI----
AqueK492_Aque   ----------------------------------------------VSK-----------
AqueK493_Aque   QGRCQGQLLRISCPK--P-VS-L--QT------------------LLSK-----------
AqueK494_Aque   VGTASGHMIVFDTTT--G-SP-L--VI---------------------------------
AqueK495_Aque   IGTNHGHLFGFCHVT--F-NL-L--IA--------V----------KQHS----SI----
AqueK496_Aque   VGTLSGIVAVFDSES--L-GL-I--AS--------F----------NWHT-G--KV----
AqueK497_Aque   IARGMGDVLVVDISG--G-KN-HGMAI---------------------------------
AqueK498_Aque   IGLVTGEILVLDHLH--L-SL-L--TT--------L----------HCHR-S--NV----


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       TPTLPSPPAPLQSPPTSGISSPTTTTSTTTDQQKINNTIFQNVHPTINVHRTSSSANLVS
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ------------------------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      -----------------RV-----------------------------------------
LRRK1_Hsap      -----------------IA-----------------------------------------
CG5483_Dmel     -----------------KS-----------------------------------------
LRRK2_Mmus      -----------------RA-----------------------------------------
LRRK1_Mmus      -----------------IA-----------------------------------------
T27C10.5_Cele   -----------------TS-----------------------------------------
GbpC_Ddis       PHGRPSNSGFGHSSGGERTINKDPHQRDSGSMDKPILSLGSGGTPRGDGARSGSISYLGR
Pats1_Ddis      ----------------IHA-----------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ----------------ITS-----------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ----------------ITS-----------------------------------------
Roco7_Ddis      ----------------IHT-----------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      -----------------VT-----------------------------------------
LRRKb_Spur      -----------------RS-----------------------------------------
LRRKa_Spur      -----------------KF-----------------------------------------
AqueK485_Aque   -----------------KV-----------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   -----------------LD-----------------------------------------
AqueK489_Aque   -----------------RQ-----------------------------------------
AqueK490_Aque   -----------------RC-----------------------------------------
AqueK491_Aque   -----------------YK-----------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   -----------------ES-----------------------------------------
AqueK496_Aque   -----------------RT-----------------------------------------
AqueK497_Aque   -----------------AR-----------------------------------------
AqueK498_Aque   -----------------HS-----------------------------------------


LRRK2_Hsap      -----------------------------------MMTAQL-------------------
LRRK1_Hsap      -----------------------------------VLKAREL------------------
CG5483_Dmel     -----------------------------------IITLSKD------------------
LRRK2_Mmus      -----------------------------------MATAQL-------------------
LRRK1_Mmus      -----------------------------------VLKAREL------------------
T27C10.5_Cele   -----------------------------------ICILEEP------------------
GbpC_Ddis       TQTSTSPLNEGLSGGQQPVMKKNDQEFCQRFALVDEIVIKDYPC----------------
Pats1_Ddis      -----------------------------------MIQVDDHVW----------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      -----------------------------------ILAMKDEVW----------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      -----------------------------------MALVEKNVW----------------
Roco7_Ddis      -----------------------------------IKRMDRFV-----------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      -----------------------------------VLNADAV------------------
LRRKb_Spur      -----------------------------------ILAVNKG------------------
LRRKa_Spur      -----------------------------------VIPVAPS------------------
AqueK485_Aque   -----------------------------------LCSIEYS------------------
AqueK486_Aque   -------------------------------------VKME-------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   -----------------------------------VAILE--------------------
AqueK489_Aque   -----------------------------------LVLLQPSYWNPDVHSKFYDDESVTT
AqueK490_Aque   -----------------------------------LITVPDA------------------
AqueK491_Aque   -----------------------------------LL-----------------------
AqueK492_Aque   -------------------------------------V----------------------
AqueK493_Aque   -------------------------------------VKME-------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   -----------------------------------IVSTGS-------------------
AqueK496_Aque   -----------------------------------LLLLPEQ------------------
AqueK497_Aque   -----------------------------------LATEDSS------------------
AqueK498_Aque   -----------------------------------FLSIDLR------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ------------------------------------------------------------
Pats1_Ddis      ------------------------------------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   DSDCGTVPFSPISGTYGGSVPSNPSLPAQNVVIPEVCSVLSCGQGVYKPIPKISEDGILL
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ----------------------------------SLNRSGRLYISQQHVCFYSKFFG---
Pats1_Ddis      ----------------------------------TASSDGTIKVWSSTC--------QSV
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ----------------------------------SGGSDGRIYIWKVKN-------EFEL
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ----------------------------------ISCEDESLSVWDGDT-------GSFI
Roco7_Ddis      ----------------------------------ITCSERVICIFD-ES--------GII
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   HDTDPVNGLCVLKMDGPDASGCIKLECQAQR-QSRPYM----------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   -----------------------KLGCRVFPRHWLPTL----------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       -----------YKTKKVIPFKNIDKLICINVNQIELTRLKNTVPSNYRLTFQTGKDREDA
Pats1_Ddis      HT--IENAHS---------------------------------SRIF-----------TL
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      QKVQSLEAHH---------------------------------EKIT-----------SL
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      RKV---GSPIGSPT----------------------------KPTVYT----------KL
Roco7_Ddis      KK--RLDGLA---------------------------------SRVL-----------SL
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ---QQLQQ-Q---------------------------------KQSP-----------KQ
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ---------ANYNE----------------------------------------------
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ---------IGRNN----------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------TP----------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------NR----------------------------------------------------
T27C10.5_Cele   ------S-----------------------------------------------------
GbpC_Ddis       FSMIHILWD-SSK----VSNSSSDE-----------------------------------
Pats1_Ddis      ELVGDFVWSGSWDTTIKIWSTK---D----------------------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ---------------WNQFVC---------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      IHLEDNVLSGSTDKCISLFKIS---D----------------------------------
Roco5_Ddis      ---------------LKQFTA---------------------------------------
Roco6_Ddis      LYFSGYVWA-CTQGSIHIYCIHSLT-----------------------------------
Roco7_Ddis      LILDTYIIGACYDSTILVWDSK--QN----------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      L------------------------Q----------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------VK----------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------HH----------------HH----------------------------------
AqueK485_Aque   ------D-----------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ----------------------ALYTNVSRATSFNESHRLLPPTPSVNNEATPNELSSDV
AqueK490_Aque   ------SV----------------DN----------------------------------
AqueK491_Aque   ----------------------AIEY----------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------VK----------------AC----------------------------------
AqueK497_Aque   -------K----------------------------------------------------
AqueK498_Aque   ------KL----------------LP----------------------------------


LRRK2_Hsap      ----------------------GNL-----------------------------------
LRRK1_Hsap      ---------------------HGVL--VDA-------A--VV------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ----------------------GSL-----------------------------------
LRRK1_Mmus      ---------------------HGVL--VDA-------A--VV------------------
T27C10.5_Cele   -REE---ENTRGKA--TTLST-----ASSESGL-GW--VRERVSE-TVDRF---------
GbpC_Ddis       I--KN--------------------------K-LA--AERKKVNNLTLKTRSNKNKGDEL
Pats1_Ddis      Y--HLV-------------------------S-EN--S--GK----------H-------
QkgA_Ddis       F--DSP------------------------------------------------------
QkgA_C2d_Ddis   F--DSP------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      P--KKP-------------------------F-TT--Q--EH----------H-------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      C--KK--------------------------K-VE--S--KN----------H-------
Roco7_Ddis      F--RMV-------------------------Q-SL--K--KK----------H-------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      Q--QKP-------------------------L-PT--P----------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      -----------GD--------NGRV--VEL-------H--RT------------------
LRRKb_Spur      -----------------L----GVG-----------------------------------
LRRKa_Spur      LVPDLPD--S------SII---PDHQ----SEVAVAHR--FR------------------
AqueK485_Aque   --------------------------EVSGCIM-VW--E---------------------
AqueK486_Aque   ----------------------GNF-----------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ---------G------HIE---PNGYTSFFSTFLGRQR--ER------------------
AqueK489_Aque   Y--ESI-------------------------VLS------PK----------H-------
AqueK490_Aque   F--QVV-------------------------L-SG--G--FG----------E-------
AqueK491_Aque   Y--KEL-------------------------L-D------EE----------E-------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ----------------------GNF-----------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   VCAEVPFDDGEATATEKVFKSNSNWTNNPCYL----NN--TL------------------
AqueK497_Aque   -----------------Y----GNR-----------------------------------
AqueK498_Aque   PQQE---YQGLGAMTPTVYPSHPFLTNSDQSDV---KY--KT------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------RSSPAT------
GbpC_Ddis       TKEDWELIGCEGSRSSTFKKDEVIIREGERMQKIFQIGKGVCRIEKSVPVAPGSSEMKKV
Pats1_Ddis      ---------------------------------------------------KDA------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ---------------------------------------------------KQG------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ---------------------------------------------------PNS------
Roco7_Ddis      ---------------------------------------------------TDA------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   ---------------------------------------------------DPE------
AqueK490_Aque   ---------------------------------------------------HSY------
AqueK491_Aque   ---------------------------------------------------MAE------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ----------------------------------------------------------AK
CG5483_Dmel     -----------------------------------------------------------N
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ----------------------------------------------------------AK
T27C10.5_Cele   -------------------------------------------------------VETQG
GbpC_Ddis       VLGTMKQDDTFGEITYLLNGETTADVIADTDQT---------------------------
Pats1_Ddis      ----------------------ISS------FVYI------------------------S
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ----------------------VTS------IVKV-------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ----------------------IVD------LI---------------------------
Roco7_Ddis      ----------------------ISS------LAFA--------------------LSPQG
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ----------------------------------------------------------GS
LRRKb_Spur      ----------------------------------------------------------KN
LRRKa_Spur      ----------------------------------------------------------FS
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ----------------------------------------------------------MD
AqueK489_Aque   ----------------------LAD------FICITPSDVPSHLSDDTPVPSRTHSFVNH
AqueK490_Aque   ----------------------IRS-----------------------------------
AqueK491_Aque   ----------------------IK-----------------------------SGIIGSQ
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ----------------------------------------------------------TD
AqueK497_Aque   ----------------------------------------------------------SN
AqueK498_Aque   ----------------------------------------------------------GP


LRRK2_Hsap      ------------KNVM-LVLG--YN-----------------------------------
LRRK1_Hsap      -------------DTV-VCT---FE-----------------------------------
CG5483_Dmel     ------------VPLI-ATIGRRYRSLI----------SR------------YV------
LRRK2_Mmus      ------------KNVM-LVLG--YK-----------------------------------
LRRK1_Mmus      -------------DTV-VCS---FA-----------------------------------
T27C10.5_Cele   ------------AALV-VCIGRQFRSLS----------HR------------FV------
GbpC_Ddis       ------------------------------------------------EVYT--------
Pats1_Ddis      NDQPLQTNERPIQKQV-WS---------GSW-------------DSSICVWA--------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      --------------------------------------------QS-HIVWA--------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------KPQL-WV---------GGWDKKITTYSFFEDLESSLS-----------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      -------------NRV-VSC---HD-----------------------------------
LRRKb_Spur      ------------ESVV-VTAGMGFVQ----------------------------------
LRRKa_Spur      ------------RPTV-VTLGKGFNDLVG----------------------GYG------
AqueK485_Aque   -----------------------YQS----------------------------------
AqueK486_Aque   ------------QDVKDFDMA--YS-----------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------VPFL-LSVGPGSLDF--------------------------G------
AqueK489_Aque   ------------SPIV-AP---------VSPGFQP-----MSPSVQPKSPGV--------
AqueK490_Aque   ---------------------------------------------------S--------
AqueK491_Aque   ------------SQLL-VT---------IGHGFEG-------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------QNIKDFSMA--YR-----------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   -------------DCI-LAFGQW-------------------------------------
AqueK496_Aque   ------------HSLV-ASIGNG-------------------------------------
AqueK497_Aque   ------------HKL--CLVGNEFVV--S----------------------SQWLEPLDM
AqueK498_Aque   -------------LQL-MSFGTGFRA----------------------------------


LRRK2_Hsap      -------RKNTEGTQK-Q------------------------------------------
LRRK1_Hsap      -------NENTE------------------------------------------------
CG5483_Dmel     -------DSAES-STKS-------------------------------------------
LRRK2_Mmus      -------RKSTEGIQE-Q------------------------------------------
LRRK1_Mmus      -------NENTE------------------------------------------------
T27C10.5_Cele   -------AEEK-------------------------------------------------
GbpC_Ddis       -----------------I---------------------------------EGQ------
Pats1_Ddis      -----------------LPNDTNSRSN---------------------TIFSSDS-----
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     -----------------------TG-----------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      -----------------I------------------------------------------
Roco5_Ddis      -----------------------NN-----------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------PKQLSNN-----------------------------------
LRRKd_Spur      --------ER-----TVN------------------------------------------
LRRKc_Spur      -------NKKSD--NSVS------------------------------------------
LRRKb_Spur      -------RPGV---PHLT------------------------------------------
LRRKa_Spur      -------NSPSR-FTG-Q------------------------------------------
AqueK485_Aque   -----------T-SSKT-------------------------------------------
AqueK486_Aque   -------EGD-SG-----------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   -------KVGKS-QKSEK------------------------------------------
AqueK489_Aque   -----------------LPASTS---DPPTSPSVQPTSPSVQPKSPGVLPVSTSDPPVSP
AqueK490_Aque   -----------------A------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   -------QGD-SG-----------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   PRPRAQTDAGIF-GDQVD------------------------------------------
AqueK498_Aque   -------YYESN--DTID------------------------------------------


LRRK2_Hsap      ------------------------------------------------------------
LRRK1_Hsap      ------------------------------------------------------------
CG5483_Dmel     ------------------------------------------------------------
LRRK2_Mmus      ------------------------------------------------------------
LRRK1_Mmus      ------------------------------------------------------------
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ----------------------------------FVNILFDLNPALAS------------
Pats1_Ddis      ----------------QFNLNGGSSNSITNSNSNSNNNLNGNLNNSNNSINNNYNNNNNN
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ------------------------------------------------------------
Roco11_Ddis     ------------------------------------------------------------
Roco4_Ddis      ------------------------------------------------------------
Roco5_Ddis      ------------------------------------------------------------
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      ------------------------------------------------------------
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      ------------------------------------------------------------
LRRKb_Spur      ------------------------------------------------------------
LRRKa_Spur      ------------------------------------------------------------
AqueK485_Aque   ------------------------------------------------------------
AqueK486_Aque   ------------------------------------------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   SVPLLSPKPPLSPSAHQSSDNDHDD-GLPLTDSE--------------DEGEGYVRM---
AqueK490_Aque   ------------------------------------------------------------
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ------------------------------------------------------------
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   ------------------------------------------------------------
AqueK498_Aque   ------------------------------------------------------------


LRRK2_Hsap      --------------------------------KE----------------------IQSC
LRRK1_Hsap      ----------------------------------------------------------WC
CG5483_Dmel     -----------------------------SAVSTPTHGAAK----------SV-------
LRRK2_Mmus      --------------------------------KE----------------------IQSC
LRRK1_Mmus      ----------------------------------------------------------WC
T27C10.5_Cele   ------------------------------------------------------------
GbpC_Ddis       ----------------------------------------K-------------------
Pats1_Ddis      NNNNNNNNNNNNNNNNNNNNNNNNNYYYSNNVNSPNQAS-QSAGHLGTIHEQTSPNSATP
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     ---------------------------------------------------DIPPSSIAA
Roco11_Ddis     ----------------------------------------------------------HP
Roco4_Ddis      --------------------------------TS----------------D-----TTTP
Roco5_Ddis      ---------------------------------------------------NTSPSGSSS
Roco6_Ddis      ------------------------------------------------------------
Roco7_Ddis      ------------------------------------------------IALQTPPPSS--
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      --------------------------------------------------------DSTP
LRRKd_Spur      ------------------------------------------------------------
LRRKc_Spur      --------------------------------QI------------------------KK
LRRKb_Spur      --------------------------------ES----------------------NYSY
LRRKa_Spur      --------------------------------ER----------------------LGWY
AqueK485_Aque   -----------------------------QALVSPTQS----------------------
AqueK486_Aque   ---------------------------------E-----------------------VVC
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   --------------------------------AV----------------------TGT-
AqueK489_Aque   ---------------------------KSASVSQPPKAYKPLHKFLD-KSRSLPPARYQP
AqueK490_Aque   --------------------------------SH----------------------DNGV
AqueK491_Aque   ------------------------------------------------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   ---------------------------------E-----------------------VVC
AqueK494_Aque   ------------------------------------------------------------
AqueK495_Aque   ------------------------------------------------------------
AqueK496_Aque   ------------------------------------------------------------
AqueK497_Aque   --------------------------------AI----------------------AHQQ
AqueK498_Aque   --------------------------------YT----------------------KSSF


LRRK2_Hsap      LTVWDI------------NLPHEVQ-NLE-KHIE-VRKE---------------------
LRRK1_Hsap      LAVWRG------------WGAREFD-IFY-QSYEE-LG----------------------
CG5483_Dmel     ------P----------------------PADVD-NHIH---------------------
LRRK2_Mmus      LSIWDL------------NLPHEVQ-NLE-KHIE-VRTE---------------------
LRRK1_Mmus      LAVWRG------------WGAREFD-IFY-QSYEE-LG----------------------
T27C10.5_Cele   --------------------------------LA-DVYS---------------------
GbpC_Ddis       ---WF-------------------KY-LA----TA-LNK---------------------
Pats1_Ddis      LS--STPPGSKG--------------LMQRRTVSF-MNV---------------------
QkgA_Ddis       ------------------------------------------------------------
QkgA_C2d_Ddis   ------------------------------------------------------------
Roco10_Ddis     LN--ITLHGDYLLAYYERTDSIKQQIFRL-----S-LDS---------------------
Roco11_Ddis     DLI-----------------------------------S---------------------
Roco4_Ddis      LVLWNIP-----------------------QKWEK-KTA---------------------
Roco5_Ddis      LP--N------------STVSSPSSSFLLR----P-TGG---------------------
Roco6_Ddis      ------------------------KV-FQ----QT-VWS---------------------
Roco7_Ddis      -----YP-------------------TLA----TP-RLG---------------------
Roco8_Ddis      ------------------------------------------------------------
Roco9_Ddis      --------------------------------TKP-LDD---------------------
LRRKd_Spur      -----------------------II-RP--RSVG-QLSV---------------------
LRRKc_Spur      MCVWED------------WGQVQVE-QF--QTINNQCRK---------------------
LRRKb_Spur      ALVWDA------------ELKNQVR-YLQ-ADAE-RRKKTTESNTTRWHKISETCTSLSR
LRRKa_Spur      ILLWNM------------EYFNEDR--LE-LGND-FLDG---------------------
AqueK485_Aque   --------------------------------LQ-PVNK---------------------
AqueK486_Aque   INS--Q------------DKFDQYM-EME-NRPN--------------------------
AqueK487_Aque   ------------------------------------------------------------
AqueK488_Aque   ------------------------------------------------------------
AqueK489_Aque   LGL---------LESTDSGDSIP----------SN-PSS---------------------
AqueK490_Aque   IMSWQG------------MSSDELE-TLA-RRWRE-R-K---------------------
AqueK491_Aque   ------------LSSLKRGDSWQ----------DH-NN----------------------
AqueK492_Aque   ------------------------------------------------------------
AqueK493_Aque   INS--Q------------DKFDQFM-EME-KRPN-LLLQ---------------------
AqueK494_Aque   ---------------------------TK-RHIN-PIRS---------------------
AqueK495_Aque   ----A----------------CD--------GSPE-HSN---------------------
AqueK496_Aque   ----R----------------LQFM-TES-KTGPT-RGD---------------------
AqueK497_Aque   LTVWGA------------WSNEVIC-AQA-QQVS-DMIE---------------------
AqueK498_Aque   LLVWEA------------AGWG---------------K----------------------


LRRK2_Hsap      -----LAE----------------KMRRTSVE
LRRK1_Hsap      ------RL----------------EACTRKRR
CG5483_Dmel     -----CLL----------------W-RAKHWT
LRRK2_Mmus      -----LAD----------------KMRKTSVE
LRRK1_Mmus      ------RL----------------EACTRKRR
T27C10.5_Cele   -----IAV----------------WRTEEWAL
GbpC_Ddis       -----TLI----------------ERESQLYA
Pats1_Ddis      -----LER----------------FSNDKNRK
QkgA_Ddis       -------F----------------LKNYPASI
QkgA_C2d_Ddis   -------F----------------LKNYPASI
Roco10_Ddis     -----FIW----------------FSLKLSNV
Roco11_Ddis     -----NG-----------------VPKLQIAK
Roco4_Ddis      -----NGI----------------LPRLKFFR
Roco5_Ddis      -----TIS----------------KKLPAIPK
Roco6_Ddis      -----CCG----------------TNNVCIWS
Roco7_Ddis      -----LVN----------------VSKSKLFG
Roco8_Ddis      -------------------------DSTINSK
Roco9_Ddis      -----SSD----------------SSSEDSNN
LRRKd_Spur      -----FAY----------------KLARRPQF
LRRKc_Spur      -----RTR----------------KSGTYLEV
LRRKb_Spur      PCSPLSPY----------------MRVNGGPV
LRRKa_Spur      -----IVR----------------KKSRSTEV
AqueK485_Aque   -----YRI----------------ESEFLCDS
AqueK486_Aque   -------L----------------LLHASTSQ
AqueK487_Aque   -----------------------------MEY
AqueK488_Aque   -------------------------CINLWLV
AqueK489_Aque   -----PAK----------------KLTPEKKY
AqueK490_Aque   -----DKE----------------EAEDESRV
AqueK491_Aque   ------NF----------------VLLWLPPR
AqueK492_Aque   -------T----------------FQSIMGSC
AqueK493_Aque   -----V-S----------------ASTSTDGE
AqueK494_Aque   -----I-Q----------------SIKTTSNY
AqueK495_Aque   -----IAG----------------SQTASSPM
AqueK496_Aque   -----RSSKMERRKTGMFSLYTEDINLLIWHS
AqueK497_Aque   -----LDY----------------QASSGYES
AqueK498_Aque   ------NV----------------LSQEKRQD