TRRAP_Hsap_TRRAP IA----------RFM-PRVEIVQKHNTAARRLYIRGHNGK--------------------
SMG1_Hsap_SMG1 ------------------ITILPT-KTKPKKLLFLGSDGK--------------------
FRAP_Hsap_FRAP II-------RIQSIA-PSLQVITS-KQRPRKLTLMGSNGH--------------------
mei-41_Dmel_ATR Li----------------------------------------------------------
CG2905_Dmel_TRRAP Li----------------------------------------------------------
CG6535_Dmel_ATM Li----------------------------------------------------------
CG4549_Dmel_SMG1 Li----------------------------------------------------------
FRAP_Mmus_FRAP II-------RIQSIA-PSLQVITS-KQRPRKLTLMGSNGH--------------------
DNAPK_Mmus_DNAPK HV-------RISGFD-ERVKVMLS-LRKPKRIVIRGHDEK--------------------
ATR_Mmus_ATR AY--------LAGFD-DVVEILSS-LQKPKKISLKGSDGK--------------------
ATM_Mmus_ATM ------------------------------------------------------------
ATM_Hsap_ATM ------------------------------------------------------------
ATR_Hsap_ATR AY--------IAGFD-DMVEILAS-LQKPKKISLKGSDGK--------------------
DNAPK_Hsap_DNAPK HV-------RIAGFD-ERVTVMAS-LRRPKRIIIRGHDER--------------------
TOR_Dmel_FRAP Li----------------------------------------------------------
SMG1_Mmus_SMG1 ------------------ITILPT-KTKPKKLLFLGSDGK--------------------
TRRAP_Mmus_TRRAP IA----------RFM-PRVEIVQKHNTAARRLHIRGHNGK--------------------
ATR_Ddis_ATR At----------------------------------------------------------
DNAPK_Ddis_DNAPK At----------------------------------------------------------
SMG1_Ddis_SMG1 At----------------------------------------------------------
Tor_Ddis_FRAP At----------------------------------------------------------
TRRAP_Ddis_TRRAP At----------------------------------------------------------
CC1G_00839_Ccin_ATM I----------HKYE-NVFETAGG-VNCPKISWCYGTDGV--------------------
CC1G_08126_Ccin_ATR T---------FKEFS-DEIDVMRS-MARPRKIWITGSDGG--------------------
CC1G_00894_Ccin_FRAP ------------------------------------------------------------
CC1G_06302_Ccin_PI3K LPLPLNAKIEVTGIIPEKSSVFKS-NLYPLLLYFQCSDGS--------------------
CC1G_04234_Ccin_PI4K RI----------M------KEMISL-EEERMARMQEGDGAFVTVPQMSETSGSSKTLEDE
CC1G_13883_Ccin_PI4K ------------------------------------------------------------
CC1G_00331_Ccin_TRRAP QE-------L------------ML-ESAWRTLEWAGHKE---------------------
GK008_Glam_FRAP IT-------TIVKFY-QKVFVIRS-KQRPRKVGLVASDGE--------------------
GK009_Glam_PIKK-Unclassified G-----------------------------------------------------------
TRRAP_Hsap_TRRAP --------------------------------------------IYPYLVMNDACLTESR
SMG1_Hsap_SMG1 --------------------------------------------SYPYLFKGL---EDLH
FRAP_Hsap_FRAP --------------------------------------------EFVFLLKGH---EDLR
mei-41_Dmel_ATR ------------------------------------------------------------
CG2905_Dmel_TRRAP ------------------------------------------------------------
CG6535_Dmel_ATM ------------------------------------------------------------
CG4549_Dmel_SMG1 ------------------------------------------------------------
FRAP_Mmus_FRAP --------------------------------------------EFVFLLKGH---EDLR
DNAPK_Mmus_DNAPK --------------------------------------------EYPFLVKGG---EDLR
ATR_Mmus_ATR --------------------------------------------FYIMMCKPK---DDLR
ATM_Mmus_ATM ----------------------------------------------RQLVKGR---DDLR
ATM_Hsap_ATM ----------------------------------------------RQLVKGR---DDLR
ATR_Hsap_ATR --------------------------------------------FYIMMCKPK---DDLR
DNAPK_Hsap_DNAPK --------------------------------------------EHPFLVKGG---EDLR
TOR_Dmel_FRAP ------------------------------------------------------------
SMG1_Mmus_SMG1 --------------------------------------------SYPYLFKGL---EDLH
TRRAP_Mmus_TRRAP --------------------------------------------IYPYLVMNDACLTESR
ATR_Ddis_ATR ------------------------------------------------------------
DNAPK_Ddis_DNAPK ------------------------------------------------------------
SMG1_Ddis_SMG1 ------------------------------------------------------------
Tor_Ddis_FRAP ------------------------------------------------------------
TRRAP_Ddis_TRRAP ------------------------------------------------------------
CC1G_00839_Ccin_ATM --------------------------------------------RYKQLFKGN---DDMR
CC1G_08126_Ccin_ATR --------------------------------------------EYIMLIKPK---DDLR
CC1G_00894_Ccin_FRAP --------------------------------------------DYQYVLKGH---EDLR
CC1G_06302_Ccin_PI3K --------------------------------------------EYPVIFKDG---DDMR
CC1G_04234_Ccin_PI4K SIIRKELNKVDPSAVVFSESWAAKKSRIRQSSPYGHLASLAQWDCMSVIVKTG---GDLR
CC1G_13883_Ccin_PI4K --------------------------------------------WQQAIFKVG---DDCR
CC1G_00331_Ccin_TRRAP -----------------------------------------------------------E
GK008_Glam_FRAP --------------------------------------------YYAFLLKGH---EDLR
GK009_Glam_PIKK-Unclassified ---------------------------------------------TRLILKCG---EDTV
TRRAP_Hsap_TRRAP REERVLQLLRLLN----------PCLEKRKETTKRHL------------FFTVPRVVAVS
SMG1_Hsap_SMG1 LDERIMQFLSIVN----------TMFATINRQETPRF------------HARHYSVTPLG
FRAP_Hsap_FRAP QDERVMQLFGLVN----------TLLANDPTSLRKNL------------SIQRYAVIPLS
mei-41_Dmel_ATR ---------------------------------------------------------pi-
CG2905_Dmel_TRRAP ---------------------------------------------------------pi-
CG6535_Dmel_ATM ---------------------------------------------------------pi-
CG4549_Dmel_SMG1 ---------------------------------------------------------pi-
FRAP_Mmus_FRAP QDERVMQLFGLVN----------TLLANDPTSLRKNL------------SIQRYAVIPLS
DNAPK_Mmus_DNAPK QDQRIEQIFEVMN----------AILSQDAACSQRNM------------QLRTYRVVPMT
ATR_Mmus_ATR KDCRLMEFNSLIN----------KSLRKDAESRRREL------------HIRTYAVIPLN
ATM_Mmus_ATM QDAVMQQVFQMCN----------TLLQRNTETRKRKL------------TICTYKVVPLS
ATM_Hsap_ATM QDAVMQQVFQMCN----------TLLQRNTETRKRKL------------TICTYKVVPLS
ATR_Hsap_ATR KDCRLMEFNSLIN----------KCLRKDAESRRREL------------HIRTYAVIPLN
DNAPK_Hsap_DNAPK QDQRVEQLFQVMN----------GILAQDSACSQRAL------------QLRTYSVVPMT
TOR_Dmel_FRAP ---------------------------------------------------------pi-
SMG1_Mmus_SMG1 LDERIMQFLSIVN----------TMFATINRQETPRF------------HARHYSVTPLG
TRRAP_Mmus_TRRAP REERVLQLLRLLN----------PCLEKRKETTKRHL------------FFTVPRVVAVS
ATR_Ddis_ATR ------------------------------------------------------------
DNAPK_Ddis_DNAPK ------------------------------------------------------------
SMG1_Ddis_SMG1 ------------------------------------------------------------
Tor_Ddis_FRAP ------------------------------------------------------------
TRRAP_Ddis_TRRAP ------------------------------------------------------------
CC1G_00839_Ccin_ATM QDAVMEQVFELVN----------RILVKDRETSRRSL------------RVRSYKVVPLG
CC1G_08126_Ccin_ATR KDARLMDFDTIIN----------RLLKANADARRRKL------------YIRTYAVVPLN
CC1G_00894_Ccin_FRAP QDERVMQLFSLVN----------TLLSVDTNSFKRRL------------HIQRYPVIPLA
CC1G_06302_Ccin_PI3K QDQLVIQLFTLMD----------QLLRKEN----LDL------------KLSPYDVLATG
CC1G_04234_Ccin_PI4K QEQLAVQLIREFQ----------SIWAE----EKCAC------------WVKHFRILITG
CC1G_13883_Ccin_PI4K QDVLALQVIAMFK----------NIFE----SIGLTL------------YLFPYRVTATA
CC1G_00331_Ccin_TRRAP LDEQIAQLPDVATPRRRVFEAFIALLKQ-PAAIDKNVDFTRFLEDAMQLSLRKWVGLPQH
GK008_Glam_FRAP QDERVMQLFTLIN----------NLLMNDSYCSRRGL------------MVMKYPITPLS
GK009_Glam_PIKK-Unclassified ADYAVMQFTEELA----------KCSVN---TFFKPY------------FVAVLINIPKN
TRRAP_Hsap_TRRAP PQMRLVEDNPS-SLSLVEIYKQR----CAK-KGIEH----D-NPISR----YYDRLATVQ
SMG1_Hsap_SMG1 TRSGLIQWVDG-ATPLFGLYKRW----QQR-EAAL-----Q-AQKAQDSY------QT--
FRAP_Hsap_FRAP TNSGLIGWVPH-CDTLHALIRDY----REK-KKILL----N-IEHRIMLR------MA--
mei-41_Dmel_ATR ------------------------------------------------------------
CG2905_Dmel_TRRAP ------------------------------------------------------------
CG6535_Dmel_ATM ------------------------------------------------------------
CG4549_Dmel_SMG1 ------------------------------------------------------------
FRAP_Mmus_FRAP TNSGLIGWVPH-CDTLHALIRDY----REK-KKILL----N-IEHRIMLR------MA--
DNAPK_Mmus_DNAPK SRLGLIEWIEN-TMTLKDLLLSN----MSQEEKVAN----N-SDPKAPIRDYKDWLMKVS
ATR_Mmus_ATR DECGIIEWVNN-TAGLRPILTKI----YKE-KGVYM----TGKELR--QC------ML--
ATM_Mmus_ATM QRSGVLEWCTG-TVPIGEYLVNS----EDGAHRRYRPNDFSANQCQK-KM------ME--
ATM_Hsap_ATM QRSGVLEWCTG-TVPIGEFLVNN----EDGAHKRYRPNDFSAFQCQK-KM------ME--
ATR_Hsap_ATR DECGIIEWVNN-TAGLRPILTKL----YKE-KGVYM----TGKELR--QC------ML--
DNAPK_Hsap_DNAPK SRLGLIEWLEN-TVTLKDLLLNT----MSQEEKAAY----L-SDPRAPPCEYKDWLTKMS
TOR_Dmel_FRAP ------------------------------------------------------------
SMG1_Mmus_SMG1 TRSGLIQWVDG-ATPLFGLYKRW----QQR-EAAL-----Q-AQKAQDSY------QT--
TRRAP_Mmus_TRRAP PQMRLVEDNPS-SLSLVEIYKQR----CAK-KGIEH----D-NPISR----YYDRLATVQ
ATR_Ddis_ATR ------------------------------------------------------------
DNAPK_Ddis_DNAPK ------------------------------------------------------------
SMG1_Ddis_SMG1 ------------------------------------------------------------
Tor_Ddis_FRAP ------------------------------------------------------------
TRRAP_Ddis_TRRAP ------------------------------------------------------------
CC1G_00839_Ccin_ATM KQAGVLEFVSN-TSPLRNWLEAG----H----PIYRPGDISPKEARS-KL------YA--
CC1G_08126_Ccin_ATR EECGCIEWVQN-TSPLRPILFKY----YEA-RRIKT----WTAELEA-QC------NK--
CC1G_00894_Ccin_FRAP PNAGLLGWVQD-SDTLHVLIRDY----RES-RKVLL----N-IEYRLMLQ------MA--
CC1G_06302_Ccin_PI3K PLQGMVQFIPS-KT-IAAIVSEH----G--NV--------------L-NY------LR--
CC1G_04234_Ccin_PI4K STSGLIETIKD-AVSIHSIKKAE----YAK-RI-------A-EGR---------------
CC1G_13883_Ccin_PI4K PGCGVIDVVPN-ATSRDEMGRAK----V--------------------------------
CC1G_00331_Ccin_TRRAP FSVAHI--------PLLQHFQQF----VEL-QEAVQ-IFGSLSQTNAQ-N------LE--
GK008_Glam_FRAP QNSGLLYWVPG-CDTIISLIKEF----RQL-KRIHL----E-TEMQQIKY------RA--
GK009_Glam_PIKK-Unclassified -QVSIIEHIDGNVVPIDELLTPVFMGAKTK-AA-EF----I-NEQEP----NEDG-----
TRRAP_Hsap_TRRAP ARGTQ----A--------------------------------SHQVL---RDILKEVQSN
SMG1_Hsap_SMG1 ---------PQNPGIVPRPSELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELMEA
FRAP_Hsap_FRAP ---------PDY------------------------------DHLTLMQKVEVFEHAVNN
mei-41_Dmel_ATR ------------------------------------------------------------
CG2905_Dmel_TRRAP ------------------------------------------------------------
CG6535_Dmel_ATM ------------------------------------------------------------
CG4549_Dmel_SMG1 ------------------------------------------------------------
FRAP_Mmus_FRAP ---------PDY------------------------------DHLTLMQKVEVFEHAVNN
DNAPK_Mmus_DNAPK GKSDAGAYVLMY------------------------------SRANRTETVVAFRRRESQ
ATR_Mmus_ATR ---------PK--------------------------------SAALSEKLKVFQELLLP
ATM_Mmus_ATM ---------VQ--------------------------------KKSFEEKYDTFMTICQ-
ATM_Hsap_ATM ---------VQ--------------------------------KKSFEEKYEVFMDVCQ-
ATR_Hsap_ATR ---------PK--------------------------------SAALSEKLKVFREFLLP
DNAPK_Hsap_DNAPK GKHDVGAYMLMY------------------------------KGANRTETVTSFRKRESK
TOR_Dmel_FRAP ------------------------------------------------------------
SMG1_Mmus_SMG1 ---------PQNPsIVPRPSELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELMEA
TRRAP_Mmus_TRRAP ARGTQ----A--------------------------------SHQVL---RDILKEVQSN
ATR_Ddis_ATR ------------------------------------------------------------
DNAPK_Ddis_DNAPK ------------------------------------------------------------
SMG1_Ddis_SMG1 ------------------------------------------------------------
Tor_Ddis_FRAP ------------------------------------------------------------
TRRAP_Ddis_TRRAP ------------------------------------------------------------
CC1G_00839_Ccin_ATM ---------AS--------------------------------SRSEEDRIKAYNEVCA-
CC1G_08126_Ccin_ATR ---------IK--------------------------------DAQAADAGNIFVKKILP
CC1G_00894_Ccin_FRAP ---------PDY------------------------------ENLMLLQKVEVFEYALEN
CC1G_06302_Ccin_PI3K ---------VN--------------------------------NPD-EGSV---------
CC1G_04234_Ccin_PI4K ---------------------------------------------------------LGH
CC1G_13883_Ccin_PI4K ------------------------------------------------------------
CC1G_00331_Ccin_TRRAP ---------K--------------------------------KSSEL---KMVLQAWRER
GK008_Glam_FRAP ---------PAF------------------------------MNMALHYKVDAFKYMLTT
GK009_Glam_PIKK-Unclassified ---C---------------------------------------F-------PTFDLFMAS
TRRAP_Hsap_TRRAP MVPRSMLKE-WALHTF--PNATDYW----TFRKMFTIQLALIG-------------FAEF
SMG1_Hsap_SMG1 TPPN-LLAK-ELWSSC--TTPDEWW----RVTQSYARSTAVMS-------------MVGY
FRAP_Hsap_FRAP TAGD-DLAK-LLWLKS--PSSEVWF----DRRTNYTRSLAVMS-------------MVGY
mei-41_Dmel_ATR ------------------------------------------------------------
CG2905_Dmel_TRRAP ------------------------------------------------------------
CG6535_Dmel_ATM ------------------------------------------------------------
CG4549_Dmel_SMG1 ------------------------------------------------------------
FRAP_Mmus_FRAP TAGD-DLAK-LLWLKS--PSSEVWF----DRRTNYTRSLAVMS-------------MVGY
DNAPK_Mmus_DNAPK VPPD-LLKR-AFVKMS--TSPEAFL----ALRSHFASSHALLC-------------ISHW
ATR_Mmus_ATR RHPP-VFHE-WFLRTF--PDPTSWY----SSRSAYCRSTAVMS-------------MVGY
ATM_Mmus_ATM NFEP-VFRY-FCMEKF--LDPAVWF----EKRLAYTRSVATSS-------------IVGY
ATM_Hsap_ATM NFQP-VFRY-FCMEKF--LDPAIWF----EKRLAYTRSVATSS-------------IVGY
ATR_Hsap_ATR RHPP-IFHE-WFLRTF--PDPTSWY----SSRSAYCRSTAVMS-------------MVGY
DNAPK_Hsap_DNAPK VPAD-LLKR-AFVRMS--TSPEAFL----ALRSHFASSHALIC-------------ISHW
TOR_Dmel_FRAP ------------------------------------------------------------
SMG1_Mmus_SMG1 TPPN-LLAK-ELWSSC--TTPDEWW----RVTQSYARSTAVMS-------------MVGY
TRRAP_Mmus_TRRAP MVPRSMLKE-WALHTF--PNATDYW----TFRKMFTIQLALIG-------------FAEF
ATR_Ddis_ATR ------------------------------------------------------------
DNAPK_Ddis_DNAPK ------------------------------------------------------------
SMG1_Ddis_SMG1 ------------------------------------------------------------
Tor_Ddis_FRAP ------------------------------------------------------------
TRRAP_Ddis_TRRAP ------------------------------------------------------------
CC1G_00839_Ccin_ATM VFKP-VFRH-IFTEKH--RNPRAWF----ATRLRYTRSVAASS-------------IVGH
CC1G_08126_Ccin_ATR MFPP-VFHQ-WFIETF--PDPSAWL----ENRTNYARTAAVMS-------------IVGW
CC1G_00894_Ccin_FRAP TTGQ-DLYR-VLWLKS--TNSEHWL----ERRATYTRSLAVNS-------------MVGH
CC1G_06302_Ccin_PI3K ------------------GTSGVEP----SVIDTFVRSCAGYC-------------VVTY
CC1G_04234_Ccin_PI4K V---TLLDHFKANYGD--PSSSRFL----RAQRNFAQSLAGYS-------------IVTY
CC1G_13883_Ccin_PI4K ---N-DLMG-FFVAKYGGENTVSFQ----KARLNFIQSMAAYS-------------VACY
CC1G_00331_Ccin_TRRAP -LPN-VYDDINIWS-----DLVAW-----RQNVFHSINLAYVPLIENLAQSAPGGNQNTN
GK008_Glam_FRAP SDAI-DLCR-SLWNKA--SSAEDWL----LKRMNYTRSIAVSS-------------IVGY
GK009_Glam_PIKK-Unclassified V---TALSHMEMALSK--THPCRFIALSQKNQRMFATTLAHWC-------------AVCI
TRRAP_Hsap_TRRAP VLHLNRLNPEMLQIAQDTG-KLNVAYFRFDINDATGDLDAN-----R-------------
SMG1_Hsap_SMG1 IIGLGDRHLDNVLIDMTTG-EVVHIDYNVCFEKGKS-LRVP-----E-------------
FRAP_Hsap_FRAP ILGLGDRHPSNLMLDRLSG-KILHIDFGDCFEVAMTREKFP-----E-------------
mei-41_Dmel_ATR ------------------------------------------------------------
CG2905_Dmel_TRRAP ------------------------------------------------------------
CG6535_Dmel_ATM ------------------------------------------------------------
CG4549_Dmel_SMG1 ------------------------------------------------------------
FRAP_Mmus_FRAP ILGLGDRHPSNLMLDRLSG-KILHIDFGDCFEVAMTREKFP-----E-------------
DNAPK_Mmus_DNAPK LLGIGDRHLNNFMVAMETG-SVIGIDFGHAFGSATQFLPVP-----E-------------
ATR_Mmus_ATR ILGLGDRHGENILFDSFTG-ECVHVDFNCLFNKGET-FEVP-----E-------------
ATM_Mmus_ATM ILGLGDRHVQNILINEQSA-ELVHIDLGVAFEQGKI-LPTP-----E-------------
ATM_Hsap_ATM ILGLGDRHVQNILINEQSA-ELVHIDLGVAFEQGKI-LPTP-----E-------------
ATR_Hsap_ATR ILGLGDRHGENILFDSLTG-ECVHVDFNCLFNKGET-FEVP-----E-------------
DNAPK_Hsap_DNAPK ILGIGDRHLNNFMVAMETG-GVIGIDFGHAFGSATQFLPVP-----E-------------
TOR_Dmel_FRAP ------------------------------------------------------------
SMG1_Mmus_SMG1 IIGLGDRHLDNVLIDMTTG-EVVHIDYNVCFEKGKS-LRVP-----E-------------
TRRAP_Mmus_TRRAP VLHLNRLNPEMLQIAQDTG-KLNVAYFRFDINDATGDLDAN-----R-------------
ATR_Ddis_ATR ------------------------------------------------------------
DNAPK_Ddis_DNAPK ------------------------------------------------------------
SMG1_Ddis_SMG1 ------------------------------------------------------------
Tor_Ddis_FRAP ------------------------------------------------------------
TRRAP_Ddis_TRRAP ------------------------------------------------------------
CC1G_00839_Ccin_ATM ILGLGDRHTSNILLDNTTG-EVVHIDLGIAFDQGKL-LTIP-----E-------------
CC1G_08126_Ccin_ATR ILGLGDRHCENILLDVITG-DAVHIDFNCLFEKGKV-LLTP-----E-------------
CC1G_00894_Ccin_FRAP ILGLGDRHPSNLLLERSTG-KVVHIDFGDCFEVAMHREKFP-----E-------------
CC1G_06302_Ccin_PI3K ILGVGDRHLDNLLIAP-DG-HFFHVDFGYILGRDPK----P-----F-------------
CC1G_04234_Ccin_PI4K LLQVKDRHNGNILLDR-DG-HLIHIDFGFILSNTP-GNIGF-----E-------------
CC1G_13883_Ccin_PI4K ILQIKDRHNGNIMIDG-EG-HIVHIAACAYLTLVA-LILRPGGVKFE-------------
CC1G_00331_Ccin_TRRAP TYGYRGYHETAWIINRFAHVARKHGLLDVCFTYLNKIYTL-----PNIEISEAFLKLREQ
GK008_Glam_FRAP ILGLGDRHPANLMIERTTG-MVLHIDYGDCFEVAMHREQLP-----E-------------
GK009_Glam_PIKK-Unclassified VTGLGDRHSCNILIDTDDG-SVHFIDFEAVFEYPK-LLSYA-----E-------------
TRRAP_Hsap_TRRAP -PVPFRLTPNISEFLTTIGVSG--PLTASMIA--VARCFAQPNFKVDGILKTVLRDEIIA
SMG1_Hsap_SMG1 -KVPFRMTQNIETALGVTGVEG--VFRLSCEQ--VLHIMRRGRETLLTLLEAFVYDPLVD
FRAP_Hsap_FRAP -KIPFRLTRMLTNAMEVTGLDG--NYRITCHT--VMEVLREHKDSVMAVLEAFVYDPLLN
mei-41_Dmel_ATR ------------------------------------------------------------
CG2905_Dmel_TRRAP ------------------------------------------------------------
CG6535_Dmel_ATM ------------------------------------------------------------
CG4549_Dmel_SMG1 ------------------------------------------------------------
FRAP_Mmus_FRAP -KIPFRLTRMLTNAMEVTGLDG--NYRTTCHT--VMEVLREHKDSVMAVLEAFVYDPLLN
DNAPK_Mmus_DNAPK -LMPFRLTRQFVSLMLPMKETG--LMCTVMVH--ALRAFRSCAGLLTDTMEIFVKEPSFD
ATR_Mmus_ATR -IVPFRLTHNMVNGMGPMGTEG--LFRRACEV--TLRLMRDQREPLMSVLKTFLHDPLVE
ATM_Mmus_ATM -TVPFRLSRDIVDGMGITGVEG--VFRRCCEK--TMEVMRSSQETLLTIVEVLLYDPLFD
ATM_Hsap_ATM -TVPFRLTRDIVDGMGITGVEG--VFRRCCEK--TMEVMRNSQETLLTIVEVLLYDPLFD
ATR_Hsap_ATR -IVPFRLTHNMVNGMGPMGTEG--LFRRACEV--TMRLMRDQREPLMSVLKTFLHDPLVE
DNAPK_Hsap_DNAPK -LMPFRLTRQFINLMLPMKETG--LMYSIMVH--ALRAFRSDPGLLTNTMDVFVKEPSFD
TOR_Dmel_FRAP ------------------------------------------------------------
SMG1_Mmus_SMG1 -KVPFRMTQNIETALGVTGVEG--VFRLSCEQ--VLHIMRRGRETLLTLLEAFVYDPLVD
TRRAP_Mmus_TRRAP -PVPFRLTPNISEFLTTIGVSG--PLTASMIA--VARCFAQPNFKVDGVLKTVLRDEIIA
ATR_Ddis_ATR ------------------------------------------------------------
DNAPK_Ddis_DNAPK ------------------------------------------------------------
SMG1_Ddis_SMG1 ------------------------------------------------------------
Tor_Ddis_FRAP ------------------------------------------------------------
TRRAP_Ddis_TRRAP ------------------------------------------------------------
CC1G_00839_Ccin_ATM -LVPFRLTRDMVDGMGISGTQG--VFQRCAEE--TLRVLRDGSDIIMTVLEVFKHDPLHS
CC1G_08126_Ccin_ATR -RVPFRLTQNIVDGLGVTGVEG--MFRIACEL--TMDLLRNNMDSLMSVLD---------
CC1G_00894_Ccin_FRAP -KVPFRLTRMLTHAMEVSGIEG--SFRNTCEI--TMTVLRDNKESLMAVLEAFVYDPLIN
CC1G_06302_Ccin_PI3K -PPAVKVCKEMVDGMGGAQSPHYMRFKNYCFT--AFSILRKSANLILNLVALMVDANIPD
CC1G_04234_Ccin_PI4K -AAPFKFPLEYLEVLGGIDGAGYKEFKRLFRE--GFEAARKHCDRIITLVELMQKDSSYP
CC1G_13883_Ccin_PI4K -PNSFKLNHEMVQLMGGRYSQGYQLFQSLTVK--AFLAIRPYAAQIVDTVQLMLDTGLPS
CC1G_00331_Ccin_TRRAP ARCHYQKPSDLQIGLEVINNTN--LMFFTAAQKAEFHTL---------------------
GK008_Glam_FRAP -KVPFRLTSIMMKAFESCGTEG--SFRMTGEA--TMSILRSNKDSLVSVLETFIYDPL--
GK009_Glam_PIKK-Unclassified -LVPFRLTALIAQLLGPTGIHG--CFYWELVK--MVSLIQENAPAFI-------------
TRRAP_Hsap_TRRAP WHKKT----------QEDTSSPLSAAG--QP--------------------E--------
SMG1_Hsap_SMG1 W-----------------------------------------------------------
FRAP_Hsap_FRAP WRLMDTNTK-GNK-RSRT-RTDSYSAG--QS--------------------V--------
mei-41_Dmel_ATR -d----------------------------------------------------------
CG2905_Dmel_TRRAP -d----------------------------------------------------------
CG6535_Dmel_ATM -d----------------------------------------------------------
CG4549_Dmel_SMG1 -d----------------------------------------------------------
FRAP_Mmus_FRAP WRLMDTNTK-GNK-RSRT-RTDSYSAG--QS--------------------V--------
DNAPK_Mmus_DNAPK WKSFEQTMLRKGG-SWIQ-EINVTEK----------------------------------
ATR_Mmus_ATR WSKP---VK-GHS-KA-----PLNETG--EV--------------------V--------
ATM_Mmus_ATM WTMNPLKALYLQQ-RPED-ESDLHSTP--NA--------------------D--------
ATM_Hsap_ATM WTMNPLKALYLQQ-RPED-ETELHPTL--NA--------------------D--------
ATR_Hsap_ATR WSKP---VK-GHS-KA-----PLNETG--EV--------------------V--------
DNAPK_Hsap_DNAPK WKNFEQKMLKKGG-SWIQ-EINVAEK----------------------------------
TOR_Dmel_FRAP -d----------------------------------------------------------
SMG1_Mmus_SMG1 W-----------------------------------------------------------
TRRAP_Mmus_TRRAP WHKKT----------QEDTSSPLSAAG--QP--------------------E--------
ATR_Ddis_ATR ------------------------------------------------------------
DNAPK_Ddis_DNAPK ------------------------------------------------------------
SMG1_Ddis_SMG1 ------------------------------------------------------------
Tor_Ddis_FRAP ------------------------------------------------------------
TRRAP_Ddis_TRRAP ------------------------------------------------------------
CC1G_00839_Ccin_ATM WTASEIKIKRVQQ-PEAPPTTPASEAGANQPKILPSRFELGGLGIDMTSGTA--------
CC1G_08126_Ccin_ATR ------------------------------------------------------------
CC1G_00894_Ccin_FRAP W-----------------------------------------------------------
CC1G_06302_Ccin_PI3K IKHRDVHE-QIQE-K---FRLDLSEEDAI-------------------------------
CC1G_04234_Ccin_PI4K CFA-------------------V-SAD--QT--------------------A--------
CC1G_13883_Ccin_PI4K FKGEPT-IRRLRD-R---FTLSLSERQAA-------------------------------
CC1G_00331_Ccin_TRRAP ------KGMFYARLGRLD--EASAAFG--QA--------------------VQLDMTQAK
GK008_Glam_FRAP ------------------------------------------------------------
GK009_Glam_PIKK-Unclassified ------------------------------------------------------------
TRRAP_Hsap_TRRAP ---------NMDSQQLV-SLV---------------------------------QK----
SMG1_Hsap_SMG1 ------------------------------------------------------------
FRAP_Hsap_FRAP ---------EILDGVELGEPAHKKTG-------------------------TTVPE----
mei-41_Dmel_ATR ------------------------------------------------------------
CG2905_Dmel_TRRAP ------------------------------------------------------------
CG6535_Dmel_ATM ------------------------------------------------------------
CG4549_Dmel_SMG1 ------------------------------------------------------------
FRAP_Mmus_FRAP ---------EILDGVELGEPAHKKAG-------------------------TTVPE----
DNAPK_Mmus_DNAPK ---------NWYPQHKIR-YAKRKLA------------GA---------N-PAV-I----
ATR_Mmus_ATR ---------NEKAKTHVLD-IEQRLQ------------GVIKTRNRVTGLPLSIEG----
ATM_Mmus_ATM ---------DQECKQSLSD-TDQSFN--------------------------KVAE----
ATM_Hsap_ATM ---------DQECKRNLSD-IDQSFN--------------------------KVAE----
ATR_Hsap_ATR ---------NEKAKTHVLD-IEQRLQ------------GVIKTRNRVTGLPLSIEG----
DNAPK_Hsap_DNAPK ---------NWYPRQKIC-YAKRKLA------------GA---------N-PAV-I----
TOR_Dmel_FRAP ------------------------------------------------------------
SMG1_Mmus_SMG1 ------------------------------------------------------------
TRRAP_Mmus_TRRAP ---------NMDSQQLV-SLV---------------------------------QK----
ATR_Ddis_ATR ------------------------------------------------------------
DNAPK_Ddis_DNAPK ------------------------------------------------------------
SMG1_Ddis_SMG1 ------------------------------------------------------------
Tor_Ddis_FRAP ------------------------------------------------------------
TRRAP_Ddis_TRRAP ------------------------------------------------------------
CC1G_00839_Ccin_ATM ---------EEAADRALSS-VARKLD------------K-----------SLSVES----
CC1G_08126_Ccin_ATR ------------------------------------------------------------
CC1G_00894_Ccin_FRAP ------------------------------------------------------------
CC1G_06302_Ccin_PI3K ----------KHFETLLNE--TSYFT--------------------------VVLD----
CC1G_04234_Ccin_PI4K ---------NQLRDRFMPTLT-HSLV------------GE------------HVERLIAS
CC1G_13883_Ccin_PI4K ----------DYMMGVIR-NAHENVR-------------------------STAYD----
CC1G_00331_Ccin_TRRAP VWAEWGRYNDQRFKENPAD-LTLAASAVSCYLQAAGLYK--------CG--KSR-P----
GK008_Glam_FRAP ------------------------------------------------------------
GK009_Glam_PIKK-Unclassified ------------------------------------------------------------
TRRAP_Hsap_TRRAP ---A------------VTAIMTR
SMG1_Hsap_SMG1 ----------------------T
FRAP_Hsap_FRAP --SI------------HSFIGDG
mei-41_Dmel_ATR -----------------kinase
CG2905_Dmel_TRRAP -----------------kinase
CG6535_Dmel_ATM -----------------kinase
CG4549_Dmel_SMG1 -----------------kinase
FRAP_Mmus_FRAP --SI------------HSFIGDG
DNAPK_Mmus_DNAPK --TC------------DELYLGH
ATR_Mmus_ATR --HV------------HYLIQEA
ATM_Mmus_ATM --RV------------LMRLQEK
ATM_Hsap_ATM --RV------------LMRLQEK
ATR_Hsap_ATR --HV------------HYLIQEA
DNAPK_Hsap_DNAPK --TC------------DELLLGH
TOR_Dmel_FRAP -----------------kinase
SMG1_Mmus_SMG1 ----------------------T
TRRAP_Mmus_TRRAP ---A------------VTAIMTR
ATR_Ddis_ATR -----------------ypical
DNAPK_Ddis_DNAPK -----------------ypical
SMG1_Ddis_SMG1 -----------------ypical
Tor_Ddis_FRAP -----------------ypical
TRRAP_Ddis_TRRAP -----------------ypical
CC1G_00839_Ccin_ATM --TVNELIAIATDPTNLGKIFYG
CC1G_08126_Ccin_ATR ---------------------AF
CC1G_00894_Ccin_FRAP ---------------------RL
CC1G_06302_Ccin_PI3K --RI------------HDLAQYW
CC1G_04234_Ccin_PI4K SLGS------------HWTRLYD
CC1G_13883_Ccin_PI4K --EF------------QRLQNGI
CC1G_00331_Ccin_TRRAP --LL------------MRVLYLL
GK008_Glam_FRAP --------------------MSM
GK009_Glam_PIKK-Unclassified --------------------NVF