MLK4_Hsap LELKELIGAGGFGQVYRATWQ--------------GQEVAVKAAR------QDP--EQD-
MLK3_Hsap LRLEEVIGIGGFGKVYRGSWR--------------GELVAVKAAR------QDP--DED-
MLK2_Hsap LQLEEIIGVGGFGKVYRALWR--------------GEEVAVKAAR------LDP--EKD-
MLK1_Hsap LTLEEIIGIGGFGKVYRAFWI--------------GDEVAVKAAR------HDP--DED-
slpr_Dmel LDIKEVIGSGGFCKVHRGYYD--------------GEEVAIKIAH------QTG--EDD-
MLK4_Mmus LELKELIGAGGFGQVYRATWQ--------------GQEVAVKAAR------RDP--EQD-
MLK3_Mmus LRLEEVIGIGGFGKVYRGSWR--------------GELVAVKAAR------QDP--DED-
MLK2_Mmus LQLEEIIGVGGFGKVYRAVWR--------------GEEVAVKAAR------LDP--ERD-
MLK1_Mmus LTLEEIIGIGGFGKVYRAFWA--------------GDEVAVKAAR------HDP--DED-
K11D12.10_Cele TLSDCQIGHGATATVFKMDIKIKKELQNGRMGEAVGDQMKAALKR---FNRHASNFRADV
MLK_Spur ------------------------------------------------------------
AqueK658_Aque VEIGEAIEKGAYSSTVRVRWQ--------------GTEYRGNKLHDVHLR-LEK--KKG-
AqueK659_Aque IKLGDVIGLGGFGKVYRAQYK--------------GEDVAVKVAR------HTT---YD-
MLK4_Hsap --AAAAAESVRREARLFAMLRHPNIIELRGVCLQQ---PHLCLVLEFARGGALNRALAAA
MLK3_Hsap --ISVTAESVRQEARLFAMLAHPNIIALKAVCLEE---PNLCLVMEYAAGGPLSRALAG-
MLK2_Hsap --PAVTAEQVCQEARLFGALQHPNIIALRGACLNP---PHLCLVMEYARGGALSRVLAG-
MLK1_Hsap --ISQTIENVRQEAKLFAMLKHPNIIALRGVCLKE---PNLCLVMEFARGGPLNRVLSG-
slpr_Dmel --MQRMRDNVLQEAKLFWALKHENIAALRGVCLNT----KLCLVMEYARGGSLNRILAG-
MLK4_Mmus --AAAAAESVRREARLFAMLRHPNIIQLRGVCLRQ---PHLCLVLEFARGGALNRALAAA
MLK3_Mmus --ISVTAESVRQEARLFAMLAHPNIIALKAVCLEE---PNLCLVMEYAAGGPLSRALAG-
MLK2_Mmus --PAVTAEQVRQEARLFGALQHPNIIALRGACLSP---PNLCLVMEYARGGALSRVLAG-
MLK1_Mmus --ISQTIENVRQEAKLFAMLKHPNIIALRGVCLKE---PNLCLVMEFARGGPLNRVLSG-
K11D12.10_Cele VSTDEQLEQLKREANLVNGLSHNNIVRLLGICLED---PYFGLLLELCEGSSLRNVCRNL
MLK_Spur ------------------------------------------------------------
AqueK658_Aque --GEELLGRLRRHCELVFSLNHPNLVQHIGVALSTQDGPAPILITPSLPTNLANIISAN-
AqueK659_Aque --TMKAVSDVLSEAEKFAHLAHENVCALIGVCLVK----DVCLVMEYAKGGPLSKILHE-
MLK4_Hsap NAAPDPRAPGPRRARRI--PPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLE
MLK3_Hsap --------------RRV--PPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQ
MLK2_Hsap --------------RRV--PPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILE
MLK1_Hsap --------------KRI--PPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQ
slpr_Dmel ---------------KI--PPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYE
MLK4_Mmus AS--DPRAPGPRRARRI--PPQVLVNWAVQIARGMLYLHEEAVVPILHRDLKSSNILLLE
MLK3_Mmus --------------RRV--PPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQ
MLK2_Mmus --------------RRV--PPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILE
MLK1_Mmus --------------KRI--PPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQ
K11D12.10_Cele -----------NSDAAI--PLGVLIDWATQVAEGMEYLTKQG---YVHRDLKADNVLVKE
MLK_Spur ------------------------------------------------------------
AqueK658_Aque --------------TRL--PPAVSHSILRDVSQGLAYLHNRPKAPVPHGSLSANNVLLTR
AqueK659_Aque --------------RNITLTVDIILDWSRQITEGMEYLHHEITPSLIHRDLKSSNILLQY
MLK4_Hsap KIE-----------------HDDICNKTLKITDFGLAREWH-RTTKMS------------
MLK3_Hsap PIE-----------------SDDMEHKTLKITDFGLAREWH-KTTQMS------------
MLK2_Hsap AIE-----------------NHNLADTVLKITDFGLAREWH-KTTKMS------------
MLK1_Hsap KVE-----------------NGDLSNKILKITDFGLAREWH-RTTKMS------------
slpr_Dmel AIE-----------------GNHLQQKTLKITDFGLAREMY-NTQRMS------------
MLK4_Mmus KIE-----------------HDDICNKTLKITDFGLAREWH-RTTRMS------------
MLK3_Mmus PIE-----------------GDDMEHKTLKITDFGLAREWH-KTTQMS------------
MLK2_Mmus AIE-----------------NHNLADTVLKITDFGLAREWH-KTTKMS------------
MLK1_Mmus KVE-----------------NGDLSNKILKITDFGLAREWH-RTTKMS------------
K11D12.10_Cele EVCLCMDEEMFQYAYCLKCGKRPFDKLQLKITDFGVTRKMTADANRFS------------
MLK_Spur ---------------------------QLKITDFGLAREMY-KTTRMS------------
AqueK658_Aque GLE-----------------A--------KLSNLGVAAILE-SGSGGGSKGAAIIAHTKT
AqueK659_Aque EVN-----------------PADLKGNLIKITDFGLAREIE-NTTHLS------------
*::::*:: .
MLK4_Hsap -TAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLT
MLK3_Hsap -AAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLT
MLK2_Hsap -AAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLT
MLK1_Hsap -AAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLA
slpr_Dmel -AAGTYAWMPPEVISVSTYSKFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLT
MLK4_Mmus -AAGTYAWMAPEVIRSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLT
MLK3_Mmus -AAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLT
MLK2_Mmus -AAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLT
MLK1_Mmus -AAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLA
K11D12.10_Cele -TAGTYAWLAPEAFKEGTWSEASDVWSYGVVLWELLTREEPYQGHIPATIAFQIANKGQN
MLK_Spur -AAGTYAWMAPEVIKSSLFSKSSDVWSFGILLWELLTGEVPYKGIDTLAVAYGIAVNKLT
AqueK658_Aque PEQTCYA-PPPE---EQPLTMAGDVFSFGVLVLHILSGKYP-------------------
AqueK659_Aque -GAGTYPWMAPEVIKSSEFSKKSDVWSFGVVLWEILTGEKPYSGLDMFVVAYGVGHGTLT
*. .** : .*::*:*::: .::: : *
MLK4_Hsap LPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQ---L
MLK3_Hsap LPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQ---L
MLK2_Hsap LPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVI
MLK1_Hsap LPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQ---L
slpr_Dmel LPIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQ---L
MLK4_Mmus LPIPSTCPEPFAKLMKECWEQDPHIRPSFALILQQ---L
MLK3_Mmus LPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQ---L
MLK2_Mmus LPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKQLEVI
MLK1_Mmus LPIPSTCPEPFAKLMEDCWNPDPHSRPSFTSILDQ---L
K11D12.10_Cele LSIGDSCPDRWKKLMQDCWNLEPNFRPKFSTLAIS---F
MLK_Spur LPIPSTCPEIFSKMLLDCWNYDPHERPTFSEIMQQ---L
AqueK658_Aque ---------------------------------------
AqueK659_Aque LPIPEHCPLSLRDLMSCCWKREHSKRPSFTQVKEKL-VE