MLK4_Hsap MALRGAAGAT--D-----TPV---------------------------------------
MLK3_Hsap MEPLKSLF-L--K-----SPL---G-----------------------------------
MLK2_Hsap MEEEEG------------------------------------------------------
MLK1_Hsap MEPSRALL-G---------CL---A-----------------------------------
slpr_Dmel MLPISEEQQL--QQQ---------------------------------------------
MLK4_Mmus MALPVAEGTA--D-----TPL---------------------------------------
MLK3_Mmus MEPLKNLF-L--K-----SPL---G-----------------------------------
MLK2_Mmus MEEEEG------------------------------------------------------
MLK1_Mmus MESSRSLL-G---------CL---A-----------------------------------
K11D12.10_Cele MEQASVPSYV--NI----PPI---A-----------------------------------
MLK_Spur MDTKKKKKKK--K-----KKK---K-KKKKKKKKKKKEKKNEKQKKKKKKKKKKKKKKKK
AqueK658_Aque MEVQKRLKA----------SI---G-----------------------------------
AqueK659_Aque MANTVSGEEEHLSSTTIIIPSTPDPKANYPG------------------NHLVTNSSS--
*
MLK4_Hsap ------------S-SA---------GGAP-GGS-A-------SSSSTS------------
MLK3_Hsap ----S---WN-GSGSG--------GGGGG-GGGR--------PE-GS-------------
MLK2_Hsap ------------------------------------------------AV-A--------
MLK1_Hsap ----S---AAAAAPPG--------EDGAG-AGAEE-------EEEEEEEA-A--------
slpr_Dmel --------------------------------------------QQQQQLEQLHHPQIPE
MLK4_Mmus ------------S--------------------------------PAR------------
MLK3_Mmus ----S---WN-GSGSG--------GGGGT-GGVR--------PE-GS-------------
MLK2_Mmus ------------------------------------------------AA-A--------
MLK1_Mmus ----S---AT-AAPPG--------DDATG-AGAEE-------EE-DEEEA-A--------
K11D12.10_Cele ----KTRSTSHLAPTPEHHRSVSYEDTTT-ASTSTDSVPEVRIRSESSQV-S--------
MLK_Spur EEEEK---KK-KKKTG--------GGQVSLTRTLS-------GGSESTNH-S--------
AqueK658_Aque ------------------------------------------------------------
AqueK659_Aque ----G---NNATTPMM--------DPGNG-PGLFP-------SVTPSQSLTTVATAEVPE
MLK4_Hsap ----------S-------GGSASAGAGLWAALYDYEARGEDELSLRRGQLVEVLSQDAAV
MLK3_Hsap ----------P-------KA-AGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAI
MLK2_Hsap ----------K-------EWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAV
MLK1_Hsap ----------AAVG--PGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQV
slpr_Dmel IPIP----------DLEQVETQVGDGSLWTALYDYDAQGEDELTLRRGEIVVVLSTDSEV
MLK4_Mmus ----------D-------DS-GSTSSGMWAALYDYEARGEDELSLRRGQLVEVLSQDAAV
MLK3_Mmus ----------P-------KATAAYANPVWTALFDYEPNGQDELALRKGDRVEVLSRDAAI
MLK2_Mmus ----------R-------EWGATPAGPVWTAVFDYEAVGDEELTLRRGDRVQVLSQDCAV
MLK1_Mmus ----------A-------ELGSHAALPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQV
K11D12.10_Cele ----------R-------ESPPIRASKAFVASYEYEAQKDDELNLPLGAIITLVTVE---
MLK_Spur ----------L-------NHGVLPVTSLCTAMHDYESTADDELTIHRGDLVEIISKDHAV
AqueK658_Aque ------------------------------------------------------------
AqueK659_Aque GQLNKAFKRTRSLGGSDGSKKSPGVKNIGIVIGDFKGLYPDEITLTVGERIEILSKDMIV
MLK4_Hsap SGDEGWWAGQVQ-RRLGIFPANYVAPCRPAASPAP----PP--SRPS-SPVHVAFERLEL
MLK3_Hsap SGDEGWWAGQVG-GQVGIFPSNYVSRGGGP--------------PPCE---VASFQELRL
MLK2_Hsap SGDEGWWTGQLPSGRVGVFPSNYVAPGAPAA---------P---AGLQLPQEIPFHELQL
MLK1_Hsap SGDEGWWTGQLN-QRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQ-LLEIDFAELTL
slpr_Dmel SGDVGWWTGKIG-DKVGVFPKDFVTDEDPLQLNVS----SA--IGDI-QPHEIEYNELDI
MLK4_Mmus SGDEGWWAGQVQ-RRLGIFPASYVAPCGPVPPPAP----PP--PRPC-SPVHVDFERLEL
MLK3_Mmus SGDEGWWAGQVG-GQVGIFPSNYVSRGGGP--------------PPCE---VASFQELRL
MLK2_Mmus SGDEGWWTGQLPSGRVGVFPSNYVAPAAPAA---------P---SDLQLPQEIPFHELQL
MLK1_Mmus SGDEGWWTGQLN-QRVGIFPSNYVTPRSAFSSRCQPGAEDPSCYPPIQ-LLEIDFAELTL
K11D12.10_Cele TNEDGWYRGELN-GKVGLFPSNYAREVTYKDNLVE-FKQD-----EIMLP----VAVRTL
MLK_Spur SGDDGWWMGKVG-DQQGIFPNNYVSDSQFIL---------E-KEINY-GVNEIDFNEIQL
AqueK658_Aque -------------------------------------------------PY-LLEDAVEI
AqueK659_Aque SRNIGWWAGRNSKGTVGIFPAASVKVVSQLEAQSD-----D--TDFE-YPLEIPADDIKL
:
MLK4_Hsap K-ELIGAGGFGQVYRATWQ--------------GQEVAVKA------ARQDP--EQDA--
MLK3_Hsap E-EVIGIGGFGKVYRGSWR--------------GELVAVKA------ARQDP--DEDI--
MLK2_Hsap E-EIIGVGGFGKVYRALWR--------------GEEVAVKA------ARLDP--EKDP--
MLK1_Hsap E-EIIGIGGFGKVYRAFWI--------------GDEVAVKA------ARHDP--DEDI--
slpr_Dmel K-EVIGSGGFCKVHRGYYD--------------GEEVAIKI------AHQTG--EDDM--
MLK4_Mmus K-ELIGAGGFGQVYRATWQ--------------GQEVAVKA------ARRDP--EQDA--
MLK3_Mmus E-EVIGIGGFGKVYRGSWR--------------GELVAVKA------ARQDP--DEDI--
MLK2_Mmus E-EIIGVGGFGKVYRAVWR--------------GEEVAVKA------ARLDP--ERDP--
MLK1_Mmus E-EIIGIGGFGKVYRAFWA--------------GDEVAVKA------ARHDP--DEDI--
K11D12.10_Cele SDCQIGHGATATVFKMDIKIKKELQNGRMGEAVGDQM--K-AALKRFNRHASNFRADVVS
MLK_Spur N-ELIGVGGFGKVFRGSWR--------------GEEVAVKA------AKHDP--EEDD-N
AqueK658_Aque G-EAIEKGAYSSTVRVRWQ--------------GTEYRGNKLHDVH-LRLEK--KKG---
AqueK659_Aque G-DVIGLGGFGKVYRAQYK--------------GEDVAVKV------ARHTT--Y-DT--
* *. . : * : : .
MLK4_Hsap -AAAAESVRREARLFAMLRHPNIIELRGVCLQQP---HLCLVLEFARGGALNRAL-AAAN
MLK3_Hsap -SVTAESVRQEARLFAMLAHPNIIALKAVCLEEP---NLCLVMEYAAGGPLSRAL-AG--
MLK2_Hsap -AVTAEQVCQEARLFGALQHPNIIALRGACLNPP---HLCLVMEYARGGALSRVL-AG--
MLK1_Hsap -SQTIENVRQEAKLFAMLKHPNIIALRGVCLKEP---NLCLVMEFARGGPLNRVL-SG--
slpr_Dmel -QRMRDNVLQEAKLFWALKHENIAALRGVCLNT----KLCLVMEYARGGSLNRIL-AG--
MLK4_Mmus -AAAAESVRREARLFAMLRHPNIIQLRGVCLRQP---HLCLVLEFARGGALNRAL-AAAA
MLK3_Mmus -SVTAESVRQEARLFAMLAHPNIIALKAVCLEEP---NLCLVMEYAAGGPLSRAL-AG--
MLK2_Mmus -AVTAEQVRQEARLFGALQHPNIIALRGACLSPP---NLCLVMEYARGGALSRVL-AG--
MLK1_Mmus -SQTIENVRQEAKLFAMLKHPNIIALRGVCLKEP---NLCLVMEFARGGPLNRVL-SG--
K11D12.10_Cele TDEQLEQLKREANLVNGLSHNNIVRLLGICLEDP---YFGLLLELCEGSSLRNVC-RNLN
MLK_Spur VRSTIDNVRQEAKLFSLLSHPNIISLRGACLREP---HVCIVMEYARGGSLNRLL-FG--
AqueK658_Aque GEELLGRLRRHCELVFSLNHPNLVQHIGVALSTQDGPAPILITPSL-PTNLANIISAN--
AqueK659_Aque -MKAVSDVLSEAEKFAHLAHENVCALIGVCLVK----DVCLVMEYAKGGPLSKIL-HE--
: ... . * * *: . .* :: * .
MLK4_Hsap AAPDPRAPGPRRARR--IPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEK
MLK3_Hsap -------------RR--VPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQP
MLK2_Hsap -------------RR--VPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEA
MLK1_Hsap -------------KR--IPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQK
slpr_Dmel --------------KI--PPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEA
MLK4_Mmus S--DPRAPGPRRARR--IPPQVLVNWAVQIARGMLYLHEEAVVPILHRDLKSSNILLLEK
MLK3_Mmus -------------RR--VPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQP
MLK2_Mmus -------------RR--VPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEA
MLK1_Mmus -------------KR--IPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQK
K11D12.10_Cele -----------SDAA--IPLGVLIDWATQVAEGMEYLTKQG---YVHRDLKADNVLVKEE
MLK_Spur -------------KKMAMPPNVLVNWAYQIADGMNYLHWEAPIPLIHRDLKSSNILLDQK
AqueK658_Aque -------------TR--LPPAVSHSILRDVSQGLAYLHNRPKAPVPHGSLSANNVLLTRG
AqueK659_Aque -------------RNITLTVDIILDWSRQITEGMEYLHHEITPSLIHRDLKSSNILLQYE
. : . ::: *: ** * .*.: *:*:
MLK4_Hsap IE-----------------HDDICNKTLKITDFGLAREWH-RTTKMSTA-----------
MLK3_Hsap IE-----------------SDDMEHKTLKITDFGLAREWH-KTTQMSAA-----------
MLK2_Hsap IE-----------------NHNLADTVLKITDFGLAREWH-KTTKMSAA-----------
MLK1_Hsap VE-----------------NGDLSNKILKITDFGLAREWH-RTTKMSAA-----------
slpr_Dmel IE-----------------GNHLQQKTLKITDFGLAREMY-NTQRMSAA-----------
MLK4_Mmus IE-----------------HDDICNKTLKITDFGLAREWH-RTTRMSAA-----------
MLK3_Mmus IE-----------------GDDMEHKTLKITDFGLAREWH-KTTQMSAA-----------
MLK2_Mmus IE-----------------NHNLADTVLKITDFGLAREWH-KTTKMSAA-----------
MLK1_Mmus VE-----------------NGDLSNKILKITDFGLAREWH-RTTKMSAA-----------
K11D12.10_Cele VCLCMDEEMFQYAYCLKCGKRPFDKLQLKITDFGVTRKMTADANRFSTA-----------
MLK_Spur VE-----------------HSNMYNIQLKITDFGLAREMY-KTTRMSAA-----------
AqueK658_Aque LE-----------------A--------KLSNLGVAAILE-SGSGGGSKGAAIIAHTKTP
AqueK659_Aque VN-----------------PADLKGNLIKITDFGLAREIE-NTTHLSGA-----------
: *::::*:: .
MLK4_Hsap --GTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTL
MLK3_Hsap --GTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTL
MLK2_Hsap --GTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTL
MLK1_Hsap --GTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLAL
slpr_Dmel --GTYAWMPPEVISVSTYSKFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTL
MLK4_Mmus --GTYAWMAPEVIRSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTL
MLK3_Mmus --GTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTL
MLK2_Mmus --GTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTL
MLK1_Mmus --GTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLAL
K11D12.10_Cele --GTYAWLAPEAFKEGTWSEASDVWSYGVVLWELLTREEPYQGHIPATIAFQIANKGQNL
MLK_Spur --GTYAWMAPEVIKSSLFSKSSDVWSFGILLWELLTGEVPYKGIDTLAVAYGIAVNKLTL
AqueK658_Aque EQTCYA-PPPE---EQPLTMAGDVFSFGVLVLHILSGKYPIPTGEGKKEI-----ERRGM
AqueK659_Aque --GTYPWMAPEVIKSSEFSKKSDVWSFGVVLWEILTGEKPYSGLDMFVVAYGVGHGTLTL
*. .** : .*::*:*::: .::: : * :
MLK4_Hsap PIPSTCPE--PFAKLMKECWQQDPHIRPSFALILEQLTAIEGA----VMTEM----PQES
MLK3_Hsap PIPSTCPE--PFAQLMADCWAQDPHRRPDFASILQQLEALEAQ----VLREM----PRDS
MLK2_Hsap PIPSTCPE--PFARLLEECWDPDPHGRPDFGSILKRLEVIEQS----ALFQM----PLES
MLK1_Hsap PIPSTCPE--PFAKLMEDCWNPDPHSRPSFTNILDQLTTIEES----GFFEM----PKDS
slpr_Dmel PIPKTCPE--TWGALMKSCWQTDPHKRPGFKEILKQLESIACS----KFTLT----PQES
MLK4_Mmus PIPSTCPE--PFAKLMKECWEQDPHIRPSFALILQQLTAIEEA----VLTNM----PQES
MLK3_Mmus PIPSTCPE--PFAQLMADCWAQDPHRRPDFASILQQLEALEAQ----VLREM----PRDS
MLK2_Mmus PIPSTCPE--PFARLLEECWDPDPHGRPDFGSILKQLEVIEQS----ALFQM----PLES
MLK1_Mmus PIPSTCPE--PFAKLMEDCWNPDPHSRPSFTSILDQLTTIEES----GFFEM----PKDS
K11D12.10_Cele SIGDSCPD--RWKKLMQDCWNLEPNFRPKFSTLAISFKQYAKEFKDTHLQRAPSKMAVKE
MLK_Spur PIPSTCPE--IFSKMLLDCWNYDPHERPTFSEIMQQLKDISES----PFINT----PQDS
AqueK658_Aque Y-ISQIPEKNNLLPLVKECLQNDPAQRPLALTLVERLTRFSSEQ--PLPFQT----SLEL
AqueK659_Aque PIPEHCPL--SLRDLMSCCWKREHSKRPSFTQVKEKLVEIQKT----EFLYT----SDEE
. * :: * : ** : : . .
MLK4_Hsap F--HSMQDDWKLEIQQMFDELRTKEKELRSREEELTRAALQQKSQEELLKRREQQLAERE
MLK3_Hsap F--HSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWE
MLK2_Hsap F--HSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAERE
MLK1_Hsap F--HCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAERE
slpr_Dmel F--HYMQECWRKEIAGVLHDLREKEKELRNKEEQLLRVQNEQREKANLLKIREQNLRERE
MLK4_Mmus F--HSMQEDWKLEIQQMFSELRTKEKELRSREEELSRAALQQKSQELLLRRREQQLAERE
MLK3_Mmus F--HSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWE
MLK2_Mmus F--HSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAERE
MLK1_Mmus F--HCLQDDWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAERE
K11D12.10_Cele LYSECFADKTKEEFEKRFHDLYAGSGDINRKNRHS-------------------------
MLK_Spur F--HIMQQDWKEEIQEMFDELRVKEKELRTREDELSQAEIQQKLHAALLKRREQDLAERE
AqueK658_Aque L--IT-MERREGELVTMVSQLRAGQEEVEGFGRRLSTYDEQLATIKEQMKKMEEEL----
AqueK659_Aque F--KSLQSTWKKEVKMKFNDLKKVESEVENKEKHLIQQMK---LQEERVIAMKKNLEEKE
: . . *. . :* . :: .
MLK4_Hsap ------IDVLERELNILIFQLN-QEKPKVKKRKGKFKRSRL-KLKDG-HRISLPSDFQHK
MLK3_Hsap ------LEVFERELTLLLQQVD-RERPHVRRRRGTFKRSKL-RARDGGERISMPLDFKHR
MLK2_Hsap ------MDIVERELHLLMCQLS-QEKPRVRKRKGNFKRSRLLKLREGGSHISLPSGFEHK
MLK1_Hsap ------IDILERELNIIIHQLC-QEKPRVKKRKGKFRKSRL-KLKDG-NRISLPSDFQHK
slpr_Dmel ------RVLIERELVMLQ-PVPS-KRKHKKGK------------KNKPLQISLPTGFRHT
MLK4_Mmus ------IDVLERELNVLIFQLS-QEAPHVKKRKGRFRRGRL-RLKDG-HRISLPSDFQHK
MLK3_Mmus ------LEVFERELTLLLQQVD-RERPHVRRRRGTFKRSKL-RARDGGERISMPLDFKHR
MLK2_Mmus ------MDIVERELHLLMSQLS-QEKPRVRKRKGNFKRSRLLKLREGSSHISLPSGFEHK
MLK1_Mmus ------IDILERELNIIIHQLC-QEKPRVKKRKGKFRKSRL-KLKDG-NRISLPSDFQHK
K11D12.10_Cele ------------------------IAPETKARRLKHHK------PK-KADITGPTEVKHI
MLK_Spur ------IELLERELNLVITQQQQDEKPVPKKRHGKIKANKL-R-RS-NKRISTPQDFHHK
AqueK658_Aque ---VGG--------------LE-GKTPQA---------------------AAVNSLLQPP
AqueK659_Aque QSLVDMMDKVQKQLEIIAREREK-RPPRTKKF----------------------------
MLK4_Hsap ITVQASPNLDK-----RRSLNSSSSSPPSSPTM---------------MPR---------
MLK3_Hsap ITVQASPGLDR-----RRNV--FEVGPGDSPT----------------FPR---------
MLK2_Hsap ITVQASPTLDK-----RKG--SDGASPPASPSI---------------IPR---------
MLK1_Hsap FTVQASPTMDK-----RKSLINSRSSPPASPTI---------------IPR---------
slpr_Dmel ITAVR-----------------DKAEQPGSPS----------------FSG---------
MLK4_Mmus ITVQASPTLDK-----RRSSDSGLCSPPGSPLM---------------LPR---------
MLK3_Mmus ITVQASPGLDR-----RRNV--FEVGAGDSPT----------------FPR---------
MLK2_Mmus ITVQASPTLDK-----RKG--SDGASPPASPSI---------------IPR---------
MLK1_Mmus FTVQASPTMDK-----RKSLISNRSSPPASPTI---------------IPR---------
K11D12.10_Cele LSVQKDDKNFRVKNDM--------SKTSRKIRLYVLHNSLQLTGKVLWIRRFLQVQTLPI
MLK_Spur LTVKADPSFQRGGGDPRSSHLSPEESPPKSP-----------------IPR---------
AqueK658_Aque LELTTSN---------R-SGKNDKESSSGSPIL---------------KPT---------
AqueK659_Aque ------------------------------------------------FPR---------
MLK4_Hsap ---------------LRAIQLTSDES-----------NKTWGRNTVFRQEEFED-VKRNF
MLK3_Hsap ---------------FRAIQLEPAEP-----------GQAWGRQSPRRLEDSSNGE----
MLK2_Hsap ---------------LRAIRLTPVDCGGSSSGSSSGGSGTWSRGGPPKKEELV-----GG
MLK1_Hsap ---------------LRAIQLTPGES-----------SKTWGRSSVVPKEEGEEEEKRAP
slpr_Dmel ---------------LRIVALTDGH-----------------------------------
MLK4_Mmus ---------------LRAIQLTSDEN-----------NKTRGRNMVFRQEDFED-VKRSF
MLK3_Mmus ---------------FRAIQLEPTES-----------GQTWGRQSPRRLEDSSNGE----
MLK2_Mmus ---------------LRAIRLTPMDCGGS------SGSGTWSRSGPPKKEELV-----GG
MLK1_Mmus ---------------LRAIQLTPGES-----------SKTWGRSSVVPKEEGEEEEKRAP
K11D12.10_Cele QSIIFTQCLCLLDEQLQILHLTEHLA-----------MMLWCRIR---------------
MLK_Spur ---------------LRVFALPKEQ-----------------------------------
AqueK658_Aque ---------------QSVF--------------------HWKRASPAP------------
AqueK659_Aque ---------------KM-------------------------------------------
MLK4_Hsap KKKGCTWGPNSIQMKDRTD--------------CKER-----------------------
MLK3_Hsap RRACWAWGPSSPKPGEAQN--------------GRRR-----------------------
MLK2_Hsap KKKGRTWGPSSTLQKERVG--------------GEER-----------------------
MLK1_Hsap KKKGRTWGPGTLGQKELAS--------------GDEGSPQRREKANGLSTPSESPHFHLG
slpr_Dmel --KGKTWGPSTMHQRERSL--------------LPSQLS------GG----------QPE
MLK4_Mmus KKKGCTWGPSSVQTKERPE--------------GRER-----------------------
MLK3_Mmus RRACWAWGPSSPKPGEAQN--------------GRRR-----------------------
MLK2_Mmus KKKGRTWGPSSTLQKERAG--------------GEER-----------------------
MLK1_Mmus KKKGRTWGPGTLGQKELTS--------------GDEGSPQRREKANGLSTPSESPHFHLG
K11D12.10_Cele --------------MELAMGIKIILYVKYFRSILNQ-----KSMA---------------
MLK_Spur -PKGKTWGPSTMQRKTRQK--------------TFR------------------------
AqueK658_Aque ------------------------------------------------------------
AqueK659_Aque ----LEWLTMSSR-----------------------------------------------
MLK4_Hsap IRPLSDGNSPWSTI---LI--KNQKTMP---LASLF---VDQPGSCE-------------
MLK3_Hsap SR-MDEATWYLDSDDSSPL--GSPSTPP---ALNGN------------------------
MLK2_Hsap LKGLGEGSKQWSSSAPNLG--KSPKHTP---IAPGF---ASLN-EME-------------
MLK1_Hsap LKSLVDGYKQWSSSAPNLV--KGPRSSP---ALPGF---TSLM-EMALLAASWVVPIDIE
slpr_Dmel WPAQTSTHSSFSKSAPNLD--KKQQQQNQQQVASL----TPPPG-LGILGGSGGAGGTPA
MLK4_Mmus VRPLSDGNSPWSSL---LI--KSQKTTP---LASLF---VDQPGSCE-------------
MLK3_Mmus SR-MDEATWYLDSDDSSPL--GSPSTPP---ALNGN------------------------
MLK2_Mmus LKALGEGSKQWSSSAPNLG--KSPKHTP---MAPGF---ASLN-EME-------------
MLK1_Mmus LKSLVDGYKQWSSSAPNLG--KGPRSSP---ALPGF---TSLM-EI--------------
K11D12.10_Cele ---VLNKPAGLSDTIPLFP--EEPTHYD---MGPGRPFGTNGR-AIV-------------
MLK_Spur PHTLSEATAKKFTSAPNLIHGKSP-LSP---MLDGN---WQV------------------
AqueK658_Aque ---------------------------------VGM---H--------------------
AqueK659_Aque ------------------------------------------------------------
MLK4_Hsap E----------PKLSPDGLEHRKPKQIKLPSQAY---------------IDLPLGKDAQR
MLK3_Hsap ------------------------------------------------------PP----
MLK2_Hsap E----------FAEAEDGGSSVPPSPYSTP--SY---------------LSVPLPA----
MLK1_Hsap E----------DED-SEGPGSGESRLQHSPSQSY---------------LCIPFPRGEDG
slpr_Dmel T----------PLLYPAKIYHRARSQEY-----G---------------LDHPLAY----
MLK4_Mmus E----------QKLVPEGLEHRKPKQTKFPGQAH---------------VGLPLCKDSQR
MLK3_Mmus ------------------------------------------------------PP----
MLK2_Mmus E----------FAEADE-GNNVPPSPYSTP--SY---------------LKVPLPA----
MLK1_Mmus E----------DED-SEGPGSGENHQQHSPNQSY---------------LCIPFPRGEDG
K11D12.10_Cele NQGGDYYGNISGQN-YEGFGHGRSINQS--TQYYPVGGGCDDYIPIVQKTVIKPTVGEVG
MLK_Spur -------------------------SLANPKPNW---------------LDVG--P----
AqueK658_Aque ----------------------SASAIVLEGKLY---------------IGGGMTKDLQS
AqueK659_Aque ------------------------------------------------------------
MLK4_Hsap ENPAEAESWEEAASANAATVS-----IEMTPTNSL-SRSPQRKKTESALYGCTVLLASV-
MLK3_Hsap ----------RPSLE---PEEPK----RPVPAERG-SSSGTPKLIQRALLRGTALLASL-
MLK2_Hsap ----------EPSPGARAPWEPT---PSAPPA---RWGHGARRRCDLALLGCATLLGAV-
MLK1_Hsap DGPSSDGIHEEPTPVNSATST-----PQLTPTNSLKRGGAHHRRCEVALLGCGAVLAAT-
slpr_Dmel ----------QPPPLYLVTDDSSETDTVASPTGC---FHFLKSGNSS-AASGAVHLHRFG
MLK4_Mmus EDSSEAESREEGS-------------PKGSPVNNV-GAPMLRKKTESALCECGMLLASM-
MLK3_Mmus ----------RPSPE---PEEPR----RAGPTERG-NSSGTPKLIQRALLRGTALLASL-
MLK2_Mmus ----------EPSPCVQAPWEP----PAVTPS---RPGHGARRRCDLALLSCATLLSAV-
MLK1_Mmus DGPSSDGVHEEPTPVNSATST-----PQLTPTNSLKRGGTHHRRCEVALLGCGAVLAAT-
K11D12.10_Cele NSPYSENIRCATR-----------------------------------------------
MLK_Spur ----------TPDHEDEDTHDPK----R----DSLRRKSSKPGMAETGLYGAAAILASV-
AqueK658_Aque DRILYEY--DISGMVHK--WTA-------LP------------TCPIAYFSMGVVNKT--
AqueK659_Aque ------------------------------------------------------------
MLK4_Hsap -ALGLDLRELHKAQA-----A-EEPLP---------------KEEKKKREGI-FQRASKS
MLK3_Hsap -GLGRDLQPPGGPGRERGES----------------------------------------
MLK2_Hsap -GLGADVAEARAAD------------G---------------EEQRRWLDGLFFPRAGRF
MLK1_Hsap -GLGFDLLEAGKCQLLPLEEP-EPP-A---------------REEKKRREGL-FQRSSRP
slpr_Dmel GSLGNSPAVGRKKH--SLDSSSHHPPANGSNSFALPNQLTLPSEDNNTYDHA-FYRDVIK
MLK4_Mmus -ALGLDVRKLHGAQA-----P-AKPSP----------------KMEKKEEGA-LQPASRC
MLK3_Mmus -GLGRDLQPPGGLSRERGES----------------------------------------
MLK2_Mmus -GLGADVAEARAGD------------G---------------EEQRRWLDSLFFPRPGRF
MLK1_Mmus -GLGFDLLEAGKCQLLPPEEP-EPP-A---------------REEKKRREGL-FQRASRP
K11D12.10_Cele -----NV---------------QNPQY---------------IQCK---------KNQNP
MLK_Spur -ALGYDVRTTNLAIY-----Q----SG---------------ELEHRRKEY-A-KQASAD
AqueK658_Aque ------LVLVGGLEIMTRK--TSNKLF---------------MWDKERQEW---------
AqueK659_Aque ------------------------------------------------------------
MLK4_Hsap RRSASPPTSLPSTCGEASSPPSLPLSSALGILS-----------------------T---
MLK3_Hsap -----P------------------------------------------------------
MLK2_Hsap PRGLSPPARPHGRREDVGPGLGL--APSATLVS-----------------------L---
MLK1_Hsap RRSTSPPSRKLFKKEEPMLLLGDP-SASLTLLS-----------------------L---
slpr_Dmel KMS---------------------MASSERVNS-----------------------K---
MLK4_Mmus QSSPSSLLRQPSAGRAPSGGSTLLLPSAPSHSS-----------------------K---
MLK3_Mmus -----P------------------------------------------------------
MLK2_Mmus PRGLSPTGRPGGRREDTAPGLGL--APSATLVS-----------------------L---
MLK1_Mmus RRSTSPPSRKLFKKEEPMTLLGDP-SASLTLLS-----------------------L---
K11D12.10_Cele RRIPAL------------------------------------------------------
MLK_Spur EVSTQTSDNDMNGLEDEDYLSISS-TANLTKNW-----------------------VAAP
AqueK658_Aque --CNTLPSMNVS-RQNPCVA-----SHNLSLIVAGGYRNKQVLADVEVFDQATFQWISFP
AqueK659_Aque ------------------------------------------------------------
MLK4_Hsap -----PS----FSTKCLLQMDSEDPLVDSAP---VTCDSEM---LTPDFCPTAPGSG---
MLK3_Hsap ---------------------------T-T-----------------PPTPTPAPCP---
MLK2_Hsap -----SSVSDCNSTRSLLRSDSDEAAPA-AP--------------SPPPSPPAPTPT---
MLK1_Hsap -----SSISECNSTRSLLRSDSDEIVVY-----------------EMPVSPVEAPPL---
slpr_Dmel -SS--GDLTMYNSSTPLTARDCDDAEEA-FEGGRFQPDADADDECQVPASQMRQNSTTSR
MLK4_Mmus -----SS----LSMKCLLQAGKEESSLGNAR---DLCGPTT---LTPDPGSAAPESGCE-
MLK3_Mmus ---------------------------T-A----------------PPPAQMPSPCP---
MLK2_Mmus -----SSVSDCNSTRSLLRSDSDEAAPA-AP--------------SPPPSPLA-------
MLK1_Mmus -----SSISECNSTRSLLRSDSDEIVVY-----------------EMPVSPVEAPPL---
K11D12.10_Cele ------------------------------------------------------------
MLK_Spur PST--GMWNDTNATNN-----------H-QP---------------PPPTQL--------
AqueK658_Aque PLLVPTSCASCCVVRDILYIL---------------------------------------
AqueK659_Aque ------------------------------------------------------------
MLK4_Hsap REPALMPRLDTDCSVSRNLPSSFL-QQTCGNVPYCASSKHRPSHHRRTMSDGNPTPTG-A
MLK3_Hsap TEPPPSPLICFSLK--TPD--SPP-TPAPLLL----D-LGIPVGQRSAKSP-----RRE-
MLK2_Hsap PSPSTNPLVDLELESFKKDPRQSL-TPTHVTA----A-CAVSRGHRRTPSDGALGQRGPP
MLK1_Hsap SPCTHNPLVNVRVERFKRDPNQSL-TPTHVTL----TTPSQPSSHRRTPSDGALKPE---
slpr_Dmel KSSVTFQSVSFEEP----------------------------------------------
MLK4_Mmus LIPGLRPKT--DYGVLRSMPHAIL-EQTGERLPGCAIVGDKGCHHMQMGSEETP-----L
MLK3_Mmus PELPSTPLIRLSQT--TPDAHSSP-TPGPLLL----D-LGVPSGQPSAKSP-----RRE-
MLK2_Mmus PSPSTNPLVDVELESFKKDPRQSL-TPTHVTA----A-HAVSRGHRRTPSDGALRQREPL
MLK1_Mmus TQCTHNPLVNVRVERFKRDPNQSL-TPTHVTL----TAPTQPSGHRRTPSDGALKPTAAP
K11D12.10_Cele --------------------------PMKIQS----ESNLVTSGMVFTPRDEQLNGIG-N
MLK_Spur -LVKQNPAYLDHRDSLPNDEQPLPTVRTHRRTASAD-DNLNSMRRTRTPSDSSTPSTK--
AqueK658_Aque ------------------------------------------------------------
AqueK659_Aque ------------------------------------------------------------
MLK4_Hsap TIISATGASALPLCPSPA--------PHSHLPREVSPKK---------------------
MLK3_Hsap -----EEPRGGTVSPPPGT-----------------------------SRSA---PGTPG
MLK2_Hsap -EPAGH-------GPGP-----------RDLLDFPRLPDPQALFPA--RRRP---PEFPG
MLK1_Hsap TLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLE
slpr_Dmel ------------------------------------------------------------
MLK4_Mmus WLQSAPEDSGLPHSPSPG--------PQRDLASQASLVKPEGVLGE--------------
MLK3_Mmus ------ETRGRTVSPPPGI-----------------------------SRSA---PGTPG
MLK2_Mmus -ELTNH---------GP-----------RDPLDFPRLPDPQALFPT--RRRP---LEFPG
MLK1_Mmus AVLGSRSPSSNGMSPSPGTGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQRDSTLE
K11D12.10_Cele -SLSSL--------------------SLNEPPDIPAPLPPVVT-----------------
MLK_Spur --WDSTG--DQWSTCSPGSD---VSSPFRSPPQV----------P--PRRTSFVGDSQME
AqueK658_Aque ---------GGSLYGEGGASNV------------------------------VQ--TIPL
AqueK659_Aque ------------------------------------------------------------
MLK4_Hsap ---HSTVHIVP-QRRPASLRSRSDL----------------------PQAYPQTA-----
MLK3_Hsap TPRSPPLGLIS-RPRPSPLRSRIDPWSFVS---------AGPRPSPLPSPQPAPR-----
MLK2_Hsap --RPTTLTFAP-RPRPAASRPRLDPWKLVS---------FGRTLTISPPSRPD-------
MLK1_Hsap --RPKTLEFLP-RPRPSANRQRLDPWWFVS---------PSHARSTSPANSSSTE-----
slpr_Dmel -------DFVA-TPRTTARSDLYTSSASIS---------FATYRSASPSLSSSSTTASAS
MLK4_Mmus ---CQACPALPQRPHTASVRTTSPP------------------------TWVCDK-----
MLK3_Mmus TPRSPPLGLIS-RPRPSPLRSRIDPWSFVS---------AGPRPSPLPSPQPAPR-----
MLK2_Mmus --RPTTLTFAP-RPRPAASRPRLDPWKLVS---------FGRTLSISPPSRPD-------
MLK1_Mmus --RPKTLEFLP-RPRPSANRQRLDPWWFVS---------PSHARSASPANSSSTE-----
K11D12.10_Cele ------------YPI---------PASLIS---------PSNRVSMSPPTRMA-------
MLK_Spur --RPSSLDICA-RPRPHS-RVYLTPQNQSSNESPHRRVSSSANTTPRHSYHADSS-----
AqueK658_Aque TGDPSSV-----------------GWSLVQ---------NAPLTK-----------SYAV
AqueK659_Aque ----------------------------------------EQRR----------------
MLK4_Hsap ------------------------------------------------------------
MLK3_Hsap ------------------------------------------------------------
MLK2_Hsap ------------------------------------------------------------
MLK1_Hsap ------------------------------------------------------------
slpr_Dmel PSIASTEAVNGYHMQENSILNTRRMQDVQPHPDVIKLRAQEQRQQTKNQKKQRPKHITKS
MLK4_Mmus ------------------------------------------------------------
MLK3_Mmus ------------------------------------------------------------
MLK2_Mmus ------------------------------------------------------------
MLK1_Mmus ------------------------------------------------------------
K11D12.10_Cele ------------------------------------------------------------
MLK_Spur ------------------------------------------------------------
AqueK658_Aque PSSNFLLAVGGAM-----------------------------------------------
AqueK659_Aque ------------------------------------------------------------
MLK4_Hsap --------------------------------V------SQLAQTAC-VVGRP----GPH
MLK3_Hsap --------------------------------RAPWT---LFPDSDPFWD-S------PP
MLK2_Hsap ---------------------------------TP---------------ESP----GPP
MLK1_Hsap ---------------------------------TPSNLDSCFASSSSTVEERP----GLP
slpr_Dmel KSVEAPVEGQHHEHDDHNDPQHQHHSAGSSKIRALFN---LFTRSRKKYS-KLAE-----
MLK4_Mmus --------------------------------D----------------HQVP----AL-
MLK3_Mmus --------------------------------RAPWT---LFPDSDPFWD-S------PP
MLK2_Mmus ---------------------------------TP---------------ESP----GPP
MLK1_Mmus ---------------------------------TPSNLDSCFASSSSTVEERP----GLP
K11D12.10_Cele -----------------------------------------------------------P
MLK_Spur --------------------------------TA---SYSSHSSSNASGATSPPLSNTTP
AqueK658_Aque -------------------------AGSNTPTRSVYV---YFPEMS-RWS-FLCE-----
AqueK659_Aque ------------------------------------------------------------
MLK4_Hsap P-TQFLAAKER-------------------------------------------------
MLK3_Hsap A-NPFQGGP---------------------------------------------------
MLK2_Hsap SV----------------------------------------------------------
MLK1_Hsap ALLPFQAGPL--------------------------------------------------
slpr_Dmel --HNMVGGPE--------------------------------------------------
MLK4_Mmus --ACLLGAQER-------------------------------------------------
MLK3_Mmus A-NPFRGGS---------------------------------------------------
MLK2_Mmus SV----------------------------------------------------------
MLK1_Mmus ALLPLQAGPL--------------------------------------------------
K11D12.10_Cele V-LPL-GA----------------------------------------------------
MLK_Spur HHAPFQHSFSQPQTTQQVQKYQHQHQQQQQPYQQQSHVYNAHYQQQSQVSHHQSSQHQAT
AqueK658_Aque --MPTAHAKC--------------------------------------------------
AqueK659_Aque ------------------------------------------------------------
MLK4_Hsap ---------------------------------TKSHVPSLLDADVEGQSRDYT-VPLCR
MLK3_Hsap -------------------------------------------QDCRAQTKDMG-A----
MLK2_Hsap -------------------------------------QPTLLDMDMEGQNQDST-VPLCG
MLK1_Hsap ----------------------------------PPTERTLLDLDAEGQSQDST-VPLCR
slpr_Dmel ---------------------------------FCAIDPYQTDLAMGGSSRSL-------
MLK4_Mmus ---------------------------------SRCQTPSLLDASIEGQKKDCA-MPLCR
MLK3_Mmus -------------------------------------------QDCRTQTKDMG-A----
MLK2_Mmus -------------------------------------QPTLLDMDMEGQSQDNT-VPLCG
MLK1_Mmus ----------------------------------LPAERTLLDLDAEGQSQDST-VPLCR
K11D12.10_Cele -----------------------------------MSSPRIMDKEILKN-----------
MLK_Spur QQQQHHHHTTPTHQHQYQHHPQHQHHQQYHQGVLINNRPSLLDQDMEGQKRDPT-RTLEA
AqueK658_Aque ---------------------------------IAAVLSAGRMIV-IGGNEEHAMKVEC-
AqueK659_Aque ------------------------------------------------------------
MLK4_Hsap MRSKTSRPSIYELEKEFLS
MLK3_Hsap --------Q-APWVPEAGP
MLK2_Hsap A--------------HGSH
MLK1_Hsap AELNTHRPAPYEIQQEFWS
slpr_Dmel -KRKGKKPQTQSCEQLERC
MLK4_Mmus VKSVMCQPSIYALEKDFLT
MLK3_Mmus --------Q-APWAPEAGP
MLK2_Mmus V--------------YGSH
MLK1_Mmus AELNAHGPSPYEIQQEFWS
K11D12.10_Cele ----------SSVEGTEIY
MLK_Spur K--PTKEPSVNALIK-EFL
AqueK658_Aque ----------GTTVELLSV
AqueK659_Aque --AKATDNKLP-SKTIERK