mig-15_Cele MSSS-----------GLDEIDLNSLRDPAGIFELIEVVGNGTYGQVYKGRHVKTAQLAAI
msn_Dmel MAHQQQQQLAPSVNCSLDDIDLTALKDPAGIFELIEVVGNGTYGQVYKGRHTKTGQLAAI
HGK_Mmus MAND-------SPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAI
TNIK_Mmus MASD-------SPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAI
MINK_Mmus MGDP-------APARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAI
NRK_Mmus MAGP-------GGWRDREVTDLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAV
MSN_Spur -------------------IDLKGLRDPSGVFHVLKKMGNGFRGSVMRSYHRKKGILKRI
NRK_Hsap MAGP-------GGWRDREVTDLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAV
MINK_Hsap MGDP-------APARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAI
TNIK_Hsap MASD-------SPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAI
HGK_Hsap MAND-------SPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAI
AqueK232_Aque MSP----------FKRR-----VQTKDPEGIFELIEVVGNGTYGQVFKGRHVKTGQLAAI
** *:* : : :* * * : . * *.. : :
mig-15_Cele KIMNIN------------------------EDEEDEIKLEINMLKKHSHHRNVATYYGAF
msn_Dmel KVMDVT------------------------EDEEEEIKLEINVLKKYSNHRNIATYYGAF
HGK_Mmus KVMDVT------------------------EDEEEEIKLEINMLKKYSHHRNIATYYGAF
TNIK_Mmus KVMDVT------------------------GDEEEEIKQEINMLKKYSHHRNIATYYGAF
MINK_Mmus KVMDVT------------------------EDEEEEIKQEINMLKKYSHHRNIATYYGAF
NRK_Mmus KVMNARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAF
MSN_Spur ALTMVT------------------------GNFREQLKSFSFLFVQYSHHRNIATYYGAF
NRK_Hsap KVMNARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAF
MINK_Hsap KVMDVT------------------------EDEEEEIKQEINMLKKYSHHRNIATYYGAF
TNIK_Hsap KVMDVT------------------------GDEEEEIKQEINMLKKYSHHRNIATYYGAF
HGK_Hsap KVMDVT------------------------EDEEEEIKLEINMLKKYSHHRNIATYYGAF
AqueK232_Aque KIMEVT------------------------EDEEEEIRLEVDVLRKYSYHTNIATYYGAF
: : .:::: :: ::* * *:.::****
mig-15_Cele IKKLPSSTGKHDQLWLVMEFCGSGSITDLVKNTKGGSLKEEWIAYICREILRGLYHLHQS
msn_Dmel IKKSP--PGKDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWIAYICREILRGLSYLHSN
HGK_Mmus IKKSP--PGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIH
TNIK_Mmus IKKNP--PGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQH
MINK_Mmus IKKSP--PGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAH
NRK_Mmus FKLSP--PGQRHQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAH
MSN_Spur IKKGV--KNHDDQLWLVMEFCGAGSVTDLVKATKGNALKEEWIAYICREILR--------
NRK_Hsap FKLSP--PGQRHQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAH
MINK_Hsap IKKSP--PGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAH
TNIK_Hsap IKKNP--PGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQH
HGK_Hsap IKKSP--PGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIH
AqueK232_Aque VKKSE--PGTEDQLWLVMEFCGAGSITDLVKSTKTRSLKEEWIAYVAREVLRGLSHLHKN
.* . .***:*** *.:**:**::: *. :***: ***:.**:*:
mig-15_Cele KVIHRDIKGQNVLLTDSAEVKLVDFGVSAQLDKTVGRRNTFIGTPYWMAPEVIACDESPE
msn_Dmel KVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACDENPD
HGK_Mmus HVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPD
TNIK_Mmus KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPD
MINK_Mmus KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPD
NRK_Mmus RVIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPR
MSN_Spur --------------------KIVDFGVSAQLDKTIGRRNTFIGTPYWMAPEVIACDENPD
NRK_Hsap RVIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPR
MINK_Hsap KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPD
TNIK_Hsap KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPD
HGK_Hsap HVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPD
AqueK232_Aque KVIHRDIKGQNVLLTDNADIKLVDFGVSAQLDRTIGKRNTFIGTPYWMAPEVIACDQDPH
*:********:.:* *:**:************* **:.*
mig-15_Cele ATYDSRSDLWSLGITALEMAEGHPPLCDMHPMRALFLIPRNPPPKLKRNKKWTKKFETFI
msn_Dmel ATYDNRSDLWSLGITALEMAESQPPLCDLHPMRALFLIPRNSPPRLK-SKKWSKKFHGFI
HGK_Mmus ATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLK-SKKWSKKFFSFI
TNIK_Mmus ATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLK-SKKWSKKFQSFI
MINK_Mmus ATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLK-SKKWSKKFIDFI
NRK_Mmus RSYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVK-SSGWSRKFHNFM
MSN_Spur ATYDNKSDLWSLGITALEMAEGQPPLCDMHPMRALFLIPRNPKPKLK-SKKWNKKFMDFV
NRK_Hsap RSYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVK-SSGWSRKFHNFM
MINK_Hsap ATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLK-SKKWSKKFIDFI
TNIK_Hsap ATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLK-SKKWSKKFQSFI
HGK_Hsap ATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLK-SKKWSKKFFSFI
AqueK232_Aque ATYDYRSDQWSLGITSIEIAEGEPPLCSMHPMRALFLIPRNPPPRLKMPKKWSPKFTSFI
:** :** ** ***::*:**. ****.::*:.***:* *:. * :* . *. ** *:
mig-15_Cele ETVLVKDYHQRPYTGALLRHPFIKEQPHEQTIRHSIKEHIDRNRR--VKKDDA-DYEYSG
msn_Dmel DTVLVKDYHQRPYTENLLKHGFIKDQPTDRQVRIQLKDHIDRCKKRKQEKERE-DYRYSG
HGK_Mmus EGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDET-EYEYSG
TNIK_Mmus ESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDET-EYEYSG
MINK_Mmus DTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEET-EYEYSG
NRK_Mmus EKCTIKNFLFRPTSANMLQHPFVRDIKNERHVVESLTRHLTGIIKKRQKKGIPLIFEREE
MSN_Spur DKCLIKNYQQRPDTNQLLKHSFIKDLPNERQVRIQLKDHIDRTPRE---DLST-DYEYNS
NRK_Hsap EKCTIKNFLFRPTSANMLQHPFVRDIKNERHVVESLTRHLTGIIKKRQKKGIPLIFEREE
MINK_Hsap DTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEET-EYEYSG
TNIK_Hsap ESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDET-EYEYSG
HGK_Hsap EGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDET-EYEYSG
AqueK232_Aque DQCLTKDPTKRPTSDELLRHPFVNDFP-ERQVRIQMKDQIDRMKRKKVMDDHL-SSDEEG
: * ** : :::. *:.: :: : .:. :: : . .
mig-15_Cele SEDDEPS-PNNRGPSMG--IR-------------DDS--ESSSMIPMDNT----------
msn_Dmel SDNDDDE-PQLAGEH------------------------SSIVQAPGGDT----------
HGK_Mmus SEEEEEEVPEQEGEP------------------------SSIVNVPGEST----------
TNIK_Mmus SEEEEEE--NDSGEP------------------------SSILNLPGEST----------
MINK_Mmus SEEEDDS-HGEEGEP------------------------SSIMNVPGEST----------
NRK_Mmus AIKEQYTVRRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQQLQ
MSN_Spur NESDEEPEIEDEGEP------------------------SSILPGPSEST----------
NRK_Hsap AIKEQYTVRRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQQLQ
MINK_Hsap SEEEDDS-HGEEGEP------------------------SSIMNVPGEST----------
TNIK_Hsap SEEEEEE--NDSGEP------------------------SSILNLPGEST----------
HGK_Hsap SEEEEEEVPEQEGEP------------------------SSIVNVPGEST----------
AqueK232_Aque SLEQPT-I-KKGGG----------------------------------------------
.: *
mig-15_Cele -LRKGFQKLQESSRGFAEPGAQQ-LRRLPQQPA---------------------------
msn_Dmel -LRRNFQQIQEG-RLAAEQQQQHHLMAQAQAQAA---AAHAAAQAQAQLQQQQQQAA---
HGK_Mmus -LRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLE
TNIK_Mmus -LRRDFLRLQLANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLE
MINK_Mmus -LRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVE
NRK_Mmus GAARVFMPLQALDS-APKPLKGQAQAPQRLQGA--AR-VFMPLQAQVKAKASKPLQMQIK
MSN_Spur -LRRNFLRLQQQQQQQEEGG-----------------------------------RRRLE
NRK_Hsap GAARVFMPLQALDS-APKPLKGQAQAPQRLQGA--AR-VFMPLQAQVKAKASKPLQMQIK
MINK_Hsap -LRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVE
TNIK_Hsap -LRRDFLRLQLANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLE
HGK_Hsap -LRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLE
AqueK232_Aque ------------------------------------------------------------
mig-15_Cele -----PAPFQYQQSRYVEPRRESSE----------------VKLRAVSSRGAAD------
msn_Dmel ------------------------------------------------------------
HGK_Mmus EQQRREREARRQQERE--QRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYI
TNIK_Mmus EQQRREKELRKQQERE--QRRHYEEQM-----------------RREEERRRAEHEQEYI
MINK_Mmus EQQRREREQRKLQEKE--QQRRLEDM---------------QALRREEERRQAEREQEYK
NRK_Mmus APPRLRRAARVLMPLQ--AQVRAPRL---------------LQVQSQVSKKQQAQTQTSE
MSN_Spur DD----------------------------------------------------------
NRK_Hsap APPRLRRAARVLMPLQ--AQVRAPRL---------------LQVQSQVSKKQQAQTQTSE
MINK_Hsap EQQRREREQRKLQEKE--QQRRLEDM---------------QALRREEERRQAEREQEYK
TNIK_Hsap EQQRREKELRKQQERE--QRRHYEEQM-----------------RREEERRRAEHEQEYI
HGK_Hsap EQQRREREARRQQERE--QRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYI
AqueK232_Aque ------------------------------------------------------------
mig-15_Cele -----------------------------------------GPRHSPAS-----------
msn_Dmel ------------AAAAAAAHAAQQAQQAA----------------------------QQA
HGK_Mmus RRQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDH
TNIK_Mmus RRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQR
MINK_Mmus -----------------------------RKQLEEQRQSERLQRQLQQEHAYLKSLQQQQ
NRK_Mmus -----------------------------PQDLDQVPEEFQGQDQVPEQQRQGQAPEQQQ
MSN_Spur ------------------------------------------------------------
NRK_Hsap -----------------------------PQDLDQVPEEFQGQDQVPEQQRQGQAPEQQQ
MINK_Hsap -----------------------------RKQLEEQRQSERLQRQLQQEHAYLKSLQQQQ
TNIK_Hsap RRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQR
HGK_Hsap RRQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDH
AqueK232_Aque ------------------------------------------------------------
mig-15_Cele -RPRPVSHHQRSP--Q-QSHPAAPHLADLANYEKRRRS-EREERRERERQA-HHAMPIAR
msn_Dmel QAQQPQ---------AN-RQP------------KPPSRQQVEE-----------------
HGK_Mmus RRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNH-SSPEAQ-SK
TNIK_Mmus QEQRPV-----------EKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQ-SSPAMP-HK
MINK_Mmus QQQQLQKQQQQQLLPG-DRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAK-SK
NRK_Mmus RHNQVPEQELEQNQAPE--QPEVQ-EQAAEPAQAETEAEE-PESLRVNAQVFLPLLS-QD
MSN_Spur ------------PPST------------------------------------NPLMR-SA
NRK_Hsap RHNQVPEQELEQNQAPE--QPEVQ-EQAAEPAQAETEAEE-PESLRVNAQVFLPLLS-QD
MINK_Hsap QQQQLQKQQQQQLLPG-DRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAK-SK
TNIK_Hsap QEQRPV-----------EKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQ-SSPAMP-HK
HGK_Hsap RRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNH-SSPEAQ-SK
AqueK232_Aque ------------------------------------------------------------
mig-15_Cele VSASVPAP---QQSRKM--S---EPLLITHVKPEDLDVL-----ASELSKMGGHHNGRSR
msn_Dmel -------------------PG-PPAR-PPQRLIVVPDP-PHANRP--LPPT-P-KCGEPA
HGK_Mmus QTGRVLEPPVPSRSESFSN-GNSESVHPALQRPAEPQVQ-----WSHLASLKNNVSPVSR
TNIK_Mmus VANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQI-------PHLVAVKSQGPALTA
MINK_Mmus PGSTGPEPPIPQASPGP--PG-PLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPR
NRK_Mmus H---------------------------HVLLPLHLDT-------QVLIPVEGQTEGSPQ
MSN_Spur PSRAGPV-----------------------------------------------------
NRK_Hsap H---------------------------HVLLPLHLDT-------QVLIPVEGQTEGSPQ
MINK_Hsap PGSTGPEPPIPQASPGP--PG-PLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPR
TNIK_Hsap VANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQI-------PHLVAVKSQGPALTA
HGK_Hsap QTGRVLEPPVPSRSESFSN-GNSESVHPALQRPAEPQVQ-----WSHLASLKNNVSPVSR
AqueK232_Aque ------------------------------------------------------------
mig-15_Cele EESMS-----------------------------------------------P-P-----
msn_Dmel GQTPQQQQRNSQNNFKPSLPPRRPEDHLDVLAAQLSELGVVFSQQPQPQTAAGGQGSQQ-
HGK_Mmus SHSFSDPSPKFAHHHLRS---QDP---------CPPSRSEVLSQSSDSKSEAP--DPT--
TNIK_Mmus SQSVHEQPTKGLSGFQEA---L-N---------VTSHRVEMPRQNSDPTSENP-PLPTRI
MINK_Mmus SQSLQDQPTRNLAAFPAS---HDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPN--
NRK_Mmus AQAWTLEPPQAIGSVQAL---I-E---------GLS-RDLLRAPNSNNSKPLG-PLQTLM
MSN_Spur ---------------------------------------------------------N--
NRK_Hsap AQAWTLEPPQAIGSVQAL---I-E---------GLS-RDLLRAPNSNNSKPLG-PLQTLM
MINK_Hsap SQSLQDQPTRNLAAFPAS---HDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPN--
TNIK_Hsap SQSVHEQPTKGLSGFQEA---L-N---------VTSHRVEMPRQNSDPTSENP-PLPTRI
HGK_Hsap SHSFSDPSPKFAHHHLRS---QDP---------CPPSRSEVLSQSSDSKSEAP--DPT--
AqueK232_Aque ------------------------------------------------------------
mig-15_Cele ----------------PPAPPPREASISSITDT-IDVGELDNGADAEWDDLKDIMMNG-E
msn_Dmel ---------QAQ-PEAPPRNNRQSSGLSSSGGSASGGG-------------------GSS
HGK_Mmus ----QKAWSRSDSDEVPPRVPVRTTSRSPVLSR-RDSP-------------------L-Q
TNIK_Mmus EKFDRSSWLRQE-EDIPPKVPQRTTSISPALAR-KNSP-------------------G-N
MINK_Mmus ----PPAWVRPD-NEAPPKVPQRTSSIATALNT-SGAG-------------------G-S
NRK_Mmus ENLSSNRFYSQP-EQAREKK-SKVSTLRQALAK-RLSP-------------------K-R
MSN_Spur ----PPCHPHPP-AESRPKLRQGSAKLSVCRNV-TVTS-------------------S-S
NRK_Hsap ENLSSNRFYSQP-EQAREKK-SKVSTLRQALAK-RLSP-------------------K-R
MINK_Hsap ----PPAWVRPD-NEAPPKVPQRTSSIATALNT-SGAG-------------------G-S
TNIK_Hsap EKFDRSSWLRQE-EDIPPKVPQRTTSISPALAR-KNSP-------------------G-N
HGK_Hsap ----QKAWSRSDSDEVPPRVPVRTTSRSPVLSR-RDSP-------------------L-Q
AqueK232_Aque -------------------------------DT-TGSG-------------------G--
mig-15_Cele GTLRGPNKPLPP------------------------------------------------
msn_Dmel KPAAALP--QQS------------------------------------------------
HGK_Mmus GSGQQNSQAGQR------------------------------------------------
TNIK_Mmus GSALGPRLGSQP------------------------------------------------
MINK_Mmus RPAQAVRA--RP------------------------------------------------
NRK_Mmus FRAKSS-WRPEKLELSDLEARRQRRQRRWEDIFNQHEEELRQVDKDKEDESSDNDEVFHS
MSN_Spur LRAMSWRS--WN------------------------------------------------
NRK_Hsap FRAKSS-WRPEKLELSDLEARRQRRQRRWEDIFNQHEEELRQVDKDKEDESSDNDEVFHS
MINK_Hsap RPAQAVRA--RP------------------------------------------------
TNIK_Hsap GSALGPRLGSQP------------------------------------------------
HGK_Hsap GSGQQNSQAGQR------------------------------------------------
AqueK232_Aque ------------------------------------------------------------
mig-15_Cele ---------------------------------------------TPTDGENTLVSDVRR
msn_Dmel ---------------------------------------NNH------------------
HGK_Mmus ---------------------------------------NSTSSIEPRLLWERVEKLVPR
TNIK_Mmus ---------------------------------------IRASNPDLRRTEPILESPLQR
MINK_Mmus ---------------------------------------RS-NSAWQIYLQRRAERGTPK
NRK_Mmus IQAEVQIEPLKPYISNPKKIEVQERSPSVPNNQDHAHHVKFSSSVPQRSLLEQAQKPIDI
MSN_Spur ---------------------------------------AD-ITLCPIFYE---------
NRK_Hsap IQAEVQIEPLKPYISNPKKIEVQERSPSVPNNQDHAHHVKFSSSVPQRSLLEQAQKPIDI
MINK_Hsap ---------------------------------------RS-NSAWQIYLQRRAERGTPK
TNIK_Hsap ---------------------------------------IRASNPDLRRTEPILESPLQR
HGK_Hsap ---------------------------------------NSTSSIEPRLLWERVEKLVPR
AqueK232_Aque ------------------------------------------------------------
mig-15_Cele NGN--GNSGHG------------------AYKGKKIP----EIRPGII------------
msn_Dmel -LGQPVNPLDPLD-SSDSDSEPDEPNDRARNDG-TLLASDP-P--KPLPG----------
HGK_Mmus PGS--GSSSGS------------------SNSG-SQP----GSHPGSQSGSGERFRV---
TNIK_Mmus TSS--GSSSSS------------------STPS-SQPSSQGGSQPGSQAGSSERTRV---
MINK_Mmus PPGPPAQPPGPPNASSNPDLRRSDPG-WERSDS-VLPASHG-H--LPQAGSLERNRV---
NRK_Mmus RQR-S-SQN---------------------RQN-WLAASES--------SSEEESPVTGR
MSN_Spur ------------------------------------------------NFKLDLTMA---
NRK_Hsap RQR-S-SQN---------------------RQN-WLAASES--------SSEEESPVTGR
MINK_Hsap PPGPPAQPPGPPNASSNPDLRRSDPG-WERSDS-VLPASHG-H--LPQAGSLERNRV---
TNIK_Hsap TSS--GSSSSS------------------STPS-SQPSSQGGSQPGSQAGSSERTRV---
HGK_Hsap PGS--GSSSGS------------------SNSG-SQP----GSHPGSQSGSGERFRV---
AqueK232_Aque -----------------------------------K------------------------
mig-15_Cele ------------------------------------------------------------
msn_Dmel --------LGPVSEDAN-TTTPLSHGSGGPPNRPLP------------------------
HGK_Mmus -RSSSKSEGSPSQRLENAVKKPEDKKE---VFRPLKPAG-----EVDLTALAKEL-----
TNIK_Mmus -RANSKSEGSPVLPHEPAKVKPEESRD---ITRPSRPASYKKAIDEDLTALAKELRE--L
MINK_Mmus -GVSSKPDSSPVLSPGN-KAKPDDHR-----SRPGRPASYKRAIGEDFV-LLKE-----R
NRK_Mmus RSQSSPPYSTIDQKLLVDIHVPDGFKV----GK-ISPPVYLTNEWVGYNALSEIFRNDWL
MSN_Spur -GHSAYVDSHHVLALALK-RRSQGHK-----SAK--------------------------
NRK_Hsap RSQSSPPYSTIDQKLLVDIHVPDGFKV----GK-ISPPVYLTNEWVGYNALSEIFRNDWL
MINK_Hsap -GVSSKPDSSPVLSPGN-KAKPDDHR-----SRPGRPASYKRAIGEDFV-LLKE-----R
TNIK_Hsap -RANSKSEGSPVLPHEPAKVKPEESRD---ITRPSRPASYKKAIDEDLTALAKELRE--L
HGK_Hsap -RSSSKSEGSPSQRLENAVKKPEDKKE---VFRPLKPAG-----EVDLTALAKEL-----
AqueK232_Aque ----------P-------------------------------------------------
mig-15_Cele ---------------------SLD-DDDSDSDN-EEGNEPLM----FKPIN---AS----
msn_Dmel --------P--------------T---PDDDDQAGD------------------------
HGK_Mmus RAVEDVRPPHKVTDYSSSSEESG-TTDEEDDDVEQEGADEST----SGPEDTRAAS----
TNIK_Mmus RIEETNRPMKKVTDYSSSSEESE-SSEEEEEDGESETHDGTV----AVSDIPRLIP----
MINK_Mmus TLDEAPRPPKKAMDYSSSSEEVE-SSEDDEEEGEGGPAEGSR--------DT--------
NRK_Mmus TPAPVIQPPEEDGDYVELYDASA-DTDGDDDDESNDTFEDTYDHANGNDDLDNQVDQAND
MSN_Spur ------------------------------------------------------------
NRK_Hsap TPAPVIQPPEEDGDYVELYDASA-DTDGDDDDESNDTFEDTYDHANGNDDLDNQVDQAND
MINK_Hsap TLDEAPRPPKKAMDYSSSSEEVE-SSEDDEEEGEGGPAEGSR--------DT--------
TNIK_Hsap RIEETNRPMKKVTDYSSSSEESE-SSEEEEEDGESETHDGTV----AVSDIPRLIP----
HGK_Hsap RAVEDVRPPHKVTDYSSSSEESG-TTDEEDDDVEQEGADEST----SGPEDTRAAS----
AqueK232_Aque --------------------KTEDEDDDDDDDILGAAGD-TI----LT---TR-------
mig-15_Cele ----------------------------------------------------------S-
msn_Dmel ------------------------------------------------------------
HGK_Mmus ----------------------------------------------------------SL
TNIK_Mmus ----------------------------------------------------------TG
MINK_Mmus ----------------------------------------------------------PG
NRK_Mmus VCKDHDDDNNKFVDDVNNNYYEAPSCPRASYGRDGSCKQDGYDGSRGKEEAYRGYGSHTA
MSN_Spur ------------------------------------------------------------
NRK_Hsap VCKDHDDDNNKFVDDVNNNYYEAPSCPRASYGRDGSCKQDGYDGSRGKEEAYRGYGSHTA
MINK_Hsap ----------------------------------------------------------PG
TNIK_Hsap ----------------------------------------------------------TG
HGK_Hsap ----------------------------------------------------------SL
AqueK232_Aque ----------------------------------------------------------EQ
mig-15_Cele ---------------------------------------------------------S--
msn_Dmel ------------------------------------RTLIMKRNRGGGGGG-GGGGGGGG
HGK_Mmus NLSNGET-ESVKTMIVHDDVESEP-----AMTPSKEGTLIVRQSTVDQKRA-SHH-ESNG
TNIK_Mmus APGSNEQ-YNVGMVGTHGLETSHADSF--SGSISREGTLMIRETSGEKKRS-GHS-DSNG
MINK_Mmus GRSDGDT-DSVSTMVVHDVEEITG-----TQPPYGGGTMVVQRTPEEERNL-LHA-DSNG
NRK_Mmus NRSHGGSAASEDNAAIGDQEEHAANIGSERRGSEGDGGKGVVRTSEESGALGLNG-EENC
MSN_Spur --------------------------------------FTFFDNTLLNKKL-LSK-DHNG
NRK_Hsap NRSHGGSAASEDNAAIGDQEEHAANIGSERRGSEGDGGKGVVRTSEESGALGLNG-EENC
MINK_Hsap GRSDGDT-DSVSTMVVHDVEEITG-----TQPPYGGGTMVVQRTPEEERNL-LHA-DSNG
TNIK_Hsap APGSNEQ-YNVGMVGTHGLETSHADSF--SGSISREGTLMIRETSGEKKRS-GHS-DSNG
HGK_Hsap NLSNGET-ESVKTMIVHDDVESEP-----AMTPSKEGTLIVRQSTVDQKRA-SHH-ESNG
AqueK232_Aque GASDDFT-ASTDTKLSQYAEETLI-----IRPDSEPSSSFLQDSSPEQRKA---------
mig-15_Cele R------------------G-ALPDLLPKSPQLRRQINDQTRQM----------------
msn_Dmel SSGVGADGTGLGTPGTRTSS-VLPDLLSQAS-P-------------------------AT
HGK_Mmus FAG---------------RIHLLPDLLQQSHSSSTSSTSSSPSSS-QPTP----TMSPQT
TNIK_Mmus FAG---------------HIN-LPDLVQQSHSPAGTPTEGLGRVS-T-------------
MINK_Mmus YT------------------N-LPDVVQPSHSPTENSKGQSPPS----------------
NRK_Mmus ---SETDG---------------PGLKRPASQDFEYLQEEPGGGN-EASNAIDSGAAPSA
MSN_Spur ES------------------N-LPRTSQESYGTSENGKGQLLPI----------------
NRK_Hsap ---SETDG---------------PGLKRPASQDFEYLQEEPGGGN-EASNAIDSGAAPSA
MINK_Hsap YT------------------N-LPDVVQPSHSPTENSKGQSPPS----------------
TNIK_Hsap FAG---------------HIN-LPDLVQQSHSPAGTPTEGLGRVS-T-------------
HGK_Hsap FAG---------------RIHLLPDLLQQSHSSSTSSTSSSPSSS-QPTP----TMSPQT
AqueK232_Aque ---------------------------------------DQPFSSYQPSG----GAKP--
mig-15_Cele ---SDDRADE--QPNGFQNSDSRSSI---------QHSFSNR----DREKSFVGYFGGGA
msn_Dmel PPRHDKSSSEEKQR----------SFLT------------------------FGFGAGG-
HGK_Mmus PQDKLTANETQSASSTLQKHKSSSSFTPFIDPRLLQISPSSG----TTVTSVVGFS----
TNIK_Mmus -----HSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFT----
MINK_Mmus ---KDGSGDY--QSRGLVKAPGKSSFTMFVDLGIYQPGGSG-----DSIPITALVG----
NRK_Mmus P-DHESDNK------DISESSTQSDFSAN------HSSPSKG----SGMSADANFA----
MSN_Spur ---RNGGSDY--RFKGLVRTKNMSSFTMFVSLMQHQPGSRG-----ETVNL-RLIG----
NRK_Hsap P-DHESDNK------DISESSTQSDFSAN------HSSPSKG----SGMSADANFA----
MINK_Hsap ---KDGSGDY--QSRGLVKAPGKSSFTMFVDLGIYQPGGSG-----DSIPITALVG----
TNIK_Hsap -----HSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFT----
HGK_Hsap PQDKLTANETQSASSTLQKHKSSSSFTPFIDPRLLQISPSSG----TTVTSVVGFS----
AqueK232_Aque ------------------------------------------GGAV---PR---------
mig-15_Cele GAGGGTVNRPGR---PQ-DINQ-VQ--VNVTPNSNGTPAENDAPEIRKYKKKFSGEILCA
msn_Dmel ----------------SGPSRRESHVNVNVTPT--SHEAANDTPEIRKYKKRFNSEILCA
HGK_Mmus --CDGM--RPEAI--RQDPTRKGSV--VNVNPT--NTRPQSDTPEIRKYKKRFNSEILCA
TNIK_Mmus --SELL--RQEQA--KLNEARKISV--VNVNPT--NIRPHSDTPEIRKYKKRFNSEILCA
MINK_Mmus --GEGT--RLDQL--QY-DVRKGSV--VNVNPT--NTRAHSETPEIRKYKKRFNSEILCA
NRK_Mmus --SAIL--YAGFVEVPEESPKQPSE--VNVNPL--YVSPACKKPLIHMYEKEFTSEICCG
MSN_Spur --GLAI--DLDQS--QF-LIRQSIS--VNVKPT--TPESLNDMPEIRKYRKKFNSEILCA
NRK_Hsap --SAIL--YAGFVEVPEESPKQPSE--VNVNPL--YVSPACKKPLIHMYEKEFTSEICCG
MINK_Hsap --GEGT--RLDQL--QY-DVRKGSV--VNVNPT--NTRAHSETPEIRKYKKRFNSEILCA
TNIK_Hsap --SELL--RQEQA--KLNEARKISV--VNVNPT--NIRPHSDTPEIRKYKKRFNSEILCA
HGK_Hsap --CDGM--RPEAI--RQDPTRKGSV--VNVNPT--NTRPQSDTPEIRKYKKRFNSEILCA
AqueK232_Aque -----------PI--GASGGRQGEN--G--GVV--KAEVTKMNPEIRKYKRKFTSEILCG
.: * *: *.:.*..** *.
mig-15_Cele ALWGVNLLIGTDSGLMLLDRSGQGKVYPLISRRRFDQMTVLEGQNILATISGRKRRIRVY
msn_Dmel ALWGVNLLIGTENGLMLLDRSGQGKVYQLISRRRFQQMEVLEGQNILVTISGKKNRVRVY
HGK_Mmus ALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVY
TNIK_Mmus ALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVY
MINK_Mmus ALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVY
NRK_Mmus SLWGVNLLLGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLNLLITISGHKNRLRVY
MSN_Spur SLWGVNLLIGTDSGLMLLDRSGEGKVYPLISRKRFQQMDVLESQNILVCIAGKKNKLRTY
NRK_Hsap SLWGVNLLLGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLNLLITISGHKNRLRVY
MINK_Hsap ALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVY
TNIK_Hsap ALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVY
HGK_Hsap ALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVY
AqueK232_Aque ALWGVNLLVGTDNGLMLLDRSGHGKVFPLISRRKFSQIDVLEGLNVLIGINGRKNKLRIY
:*******:** ..* *:****...: ** *: * *: *** *:* * *:: ::* *
mig-15_Cele YLSWLRQKILRTEGAGSANTTEKRN--------GWVNVGDLQGAIHFKIVRYERIKFLVV
msn_Dmel YLSWLKSKILRTDGLS--DQVERRN--------GWINVGDLQGAVHFKIVKYERIKFLVI
HGK_Mmus YLSWLRNKILHNDPE-----VEKKQ--------GWTTVGDLEGCVHYKVVKYERIKFLVI
TNIK_Mmus YLSWLRNRILHNDPE-----VEKKQ--------GWITVGDLEGCIHYKVVKYERIKFLVI
MINK_Mmus YLSWLRNKILHNDPE-----VEKKQ--------GWTTVGDMEGCGHYRVVKYERIKFLVI
NRK_Mmus HLTWLRNKILNNDPE-----SKRRQEEMLKTEEACKAIDKLTGCEHFSVLQHEETTYIAI
MSN_Spur FLSWLKQKIVRSDGE-----AKRKS--------GFLSVGDLEGCIHYKIIKYEKIKFLVI
NRK_Hsap HLTWLRNKILNNDPE-----SKRRQEEMLKTEEACKAIDKLTGCEHFSVLQHEETTYIAI
MINK_Hsap YLSWLRNKILHNDPE-----VEKKQ--------GWTTVGDMEGCGHYRVVKYERIKFLVI
TNIK_Hsap YLSWLRNRILHNDPE-----VEKKQ--------GWITVGDLEGCIHYKVVKYERIKFLVI
HGK_Hsap YLSWLRNKILHNDPE-----VEKKQ--------GWTTVGDLEGCVHYKVVKYERIKFLVI
AqueK232_Aque YLSWLKQKIMKHELD----SPHTRQ--------GFVPVGDLEHCVHYKVARSDKMKYLVI
.*:**:.:*:. : . :. . :..: . *: : : :. .::.:
mig-15_Cele GLESSIEIYAWAPKPYHKF-----------------------------------------
msn_Dmel ALKDSIEIYAWAPKPYHKF-----------------------------------------
HGK_Mmus ALKSSVEVYAWAPKPYHKF-----------------------------------------
TNIK_Mmus ALKNAVEIYAWAPKPYHKF-----------------------------------------
MINK_Mmus ALKSSVEVYAWAPKPYHKF-----------------------------------------
NRK_Mmus ALKSSIHLYAWAPKSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQAADPVNRFKR
MSN_Spur ALKDSIEIYAWAPKPYHKF-----------------------------------------
NRK_Hsap ALKSSIHLYAWAPKSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQAADPVNRFKR
MINK_Hsap ALKSSVEVYAWAPKPYHKF-----------------------------------------
TNIK_Hsap ALKNAVEIYAWAPKPYHKF-----------------------------------------
HGK_Hsap ALKSSVEVYAWAPKPYHKF-----------------------------------------
AqueK232_Aque GTKTGVEVYAWAQRPYSKF-----------------------------------------
. : .:.:**** :.: :
mig-15_Cele -------MSFKSFGSLSHVPLIVDLTVEDNARLKVLYGSTGGFHAIDLDSAAVYDIYTPA
msn_Dmel -------MAFKNFGELEHRPLLVDLTIEDQSRLKVIYGSAEGFHAVDLDSAEVYDIYLPK
HGK_Mmus -------MAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPT
TNIK_Mmus -------MAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPS
MINK_Mmus -------MAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPV
NRK_Mmus PDELLHLLKLKVFPTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAESEVMSDVTLPK
MSN_Spur -------MAFKSFPNLVHRPLIVDLTVEDNQRLKVIYGSVNGFHAIDLDSASVQDIYSPP
NRK_Hsap PDELLHLLKLKVFPTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAESEVMSDVTLPK
MINK_Hsap -------MAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPV
TNIK_Hsap -------MAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPS
HGK_Hsap -------MAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPT
AqueK232_Aque -------MAFKSFPDLPNKPILVDMVHMPGGKSKVVYASTSGFHAVDMDTGVVQNIYIPA
: :* * * : *: **:. : *:.:.* *:* :* :: :: *
mig-15_Cele QS--------GQTTTPHCIVVLPNSNGMQLLLCYDNEGVYVNTYGRMTKNVVLQWGEMPS
msn_Dmel HT--------QGAIIPHCIVALPNSNGMQLLLCYDNEGVYVNTVGRVSKNIVLQWGEMPT
HGK_Mmus HVRKNPHSMIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPT
TNIK_Mmus HI--------QGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPT
MINK_Mmus HI--------QSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPT
NRK_Mmus NP--------LEIIIPQNIIILPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDIPS
MSN_Spur QE--------IGTITPYCVVILPNSQGKYLLLCFNNEGVFVDTKGVPFKDVILQWGELPA
NRK_Hsap NP--------LEIIIPQNIIILPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDIPS
MINK_Hsap HI--------QSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPT
TNIK_Hsap HI--------QGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPT
HGK_Hsap HVRKNPHSMIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPT
AqueK232_Aque AAA-------RGPILPHAIIPLPSK-PSELLLCHNNEGVYVDSEGRSTKDTRLQWGEEPS
* :: **. ::: .: *.: *:: *. * : *:
mig-15_Cele SVAYISTGQIMGWGNKAIEIRSVDTGHLDGVFMHKKAQKLKFLCERNDKVFFSSAKGGGS
msn_Dmel SVAYIGTGQIMGWGNKAIEIRSVESGHLDGVFMHKKAQRLKFLCERNDKVFFSSAKGASS
HGK_Mmus SVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGS
TNIK_Mmus SVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGS
MINK_Mmus SVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGS
NRK_Mmus SIAFECTQRTTGWGQKAIEVRSLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRNHH
MSN_Spur SVAYISTGQIMGWGNKAIEIRSAETGHLDGVFMHKRSQQLRFLCERNDKVFFASIRP-SN
NRK_Hsap SIAFECTQRTTGWGQKAIEVRSLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRNHH
MINK_Hsap SVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGS
TNIK_Hsap SVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGS
HGK_Hsap SVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGS
AqueK232_Aque SVALIGESHVMGWGSKAIEIRAVESGQLDGVFMHKRTQKLRFLCERNDKVFFASIRSTSN
*:* : ***.****:*: :: *:. : :: ::*:*** *.**:**:*
mig-15_Cele CQIYFMTLNKPGL----TNW
msn_Dmel CQIYFMTLNKPGM----ANW
HGK_Mmus SQVYFMTLGRTSL----LSW
TNIK_Mmus SQVFFMTLNRNSM----MNW
MINK_Mmus SQVYFMTLNRNCI----MNW
NRK_Mmus SRVYFMTLGKLEELQSNYDV
MSN_Spur SQVYFLTLKRNCL------M
NRK_Hsap SRVYFMTLGKLEELQSNYDV
MINK_Hsap SQVYFMTLNRNCI----MNW
TNIK_Hsap SQVFFMTLNRNSM----MNW
HGK_Hsap SQVYFMTLGRTSL----LSW
AqueK232_Aque SQVYFMALNRSLVPSSSSSS
.:::*::* :