PAK3_Hsap MSDGL-------------------------------------------------------
PAK2_Hsap MSDNG-------------------------------------------------------
PAK1_Hsap MSNNGL------------------------------------------------------
PAK3_Mmus MSDSL-------------------------------------------------------
PAK2_Mmus MSDNG-------------------------------------------------------
PAK1_Mmus MSNNGV------------------------------------------------------
pak-1_Cele MKAFS-------------------------------------------------------
STE20_Scer MSNDPSA--------------------------------------------------VSE
SKM1_Scer MKGVKKEG-------------WISYKVDGLFSFLWQKRYLVLNDSYLAFYKS-----DK-
CLA4_Scer MSLSAAAN-------------K----------------------------IS-----DN-
Pak3_Dmel MSFTKWF--------------------------------------------------K--
Pak_Dmel MSSE--------------------------------------------------------
Y38F1A.10_Cele MFQNSPM--------------------------------------------------M--
PakA_Ddis MEEKPKST----------------------------------------------------
PakB_Ddis MEQSKRVS-MMR-------E-KFEAQ-------------------------SNEAESSP-
PakC_Ddis MISLEDLS-PTLWKSP---DKEGELKKQGHVVKNWKKRKFIIQ--------NDMLFYFK-
PakD_Ddis MSRLQPQQ-QQRGRSSSFKD-NFQ--------------------------IQKPLQS--L
19075_Tthe MPQEWTQYNL--------------------------------------------------
25909_Tthe MGGKGSKNNN-----------------------------------------------EE-
PAK1_Spur MYHHHHH--------------------------------------------------LQ-
CC1G_15304_Ccin MSLTS-------------------------------------------------------
CC1G_00840_Ccin MSSPHTA--------------------------------------------------YNQ
CC1G_02087_Ccin MSYHQVS--------------------------------------------------AN-
AqueK235_Aque MATM--------------------------------------------------------
GK081_Glam MFKKKNK-----------------------------------------------------
*
PAK3_Hsap ------------------------------------------------------------
PAK2_Hsap ------------------------------------------------------------
PAK1_Hsap ------------------------------------------------------------
PAK3_Mmus ------------------------------------------------------------
PAK2_Mmus ------------------------------------------------------------
PAK1_Mmus ------------------------------------------------------------
pak-1_Cele ------------------------------------------------------------
STE20_Scer LPDKDSLDNGISN-----------------------------------------------
SKM1_Scer ------------------------------------------------------------
CLA4_Scer ------------------------------------------------------------
Pak3_Dmel ------------------------------------------------------------
Pak_Dmel ------------------------------------------------------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis ------------------------------------------------------------
PakB_Ddis ------------------------------------------------------------
PakC_Ddis ------------------------------------------------------------
PakD_Ddis TPSEQQQQQQQQQQQQQQQQQQQQQQQQQNNANNNNNNNNNKFNNQYIQQMKNVENDIKK
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur ------------------------------------------------------------
CC1G_15304_Ccin ------------------------------------------------------------
CC1G_00840_Ccin RPKEPRRQSKITV-----------------------------------------------
CC1G_02087_Ccin ------------------------------------------------------------
AqueK235_Aque ------------------------------------------------------------
GK081_Glam ------------------------------------------------------------
PAK3_Hsap ------------------------------------------------------------
PAK2_Hsap ------------------------------------------------------------
PAK1_Hsap ------------------------------------------------------------
PAK3_Mmus ------------------------------------------------------------
PAK2_Mmus ------------------------------------------------------------
PAK1_Mmus ------------------------------------------------------------
pak-1_Cele ------------------------------------------------------------
STE20_Scer ------------------------------------------------------------
SKM1_Scer ------------------------------------------------------------
CLA4_Scer ------------------------------------------------------------
Pak3_Dmel ------------------------------------------------------------
Pak_Dmel ------------------------------------------------------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis ------------------------------------------------------------
PakB_Ddis ------------------------------------------------------------
PakC_Ddis ------------------------------------------------------------
PakD_Ddis WIGEKCSSSLSDDFLEKDLMESLCTGTILCVLINMIKQGTIQKIHLQPNYLQRVENIRNY
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur ------------------------------------------------------------
CC1G_15304_Ccin ------------------------------------------------------------
CC1G_00840_Ccin ------------------------------------------------------------
CC1G_02087_Ccin ------------------------------------------------------------
AqueK235_Aque ------------------------------------------------------------
GK081_Glam ------------------------------------------------------------
PAK3_Hsap ------------------------------------------------------------
PAK2_Hsap ------------------------------------------------------------
PAK1_Hsap ------------------------------------------------------------
PAK3_Mmus ------------------------------------------------------------
PAK2_Mmus ------------------------------------------------------------
PAK1_Mmus ------------------------------------------------------------
pak-1_Cele ------------------------------------------------------------
STE20_Scer ------------------------------------------------DNERAMGGNGDG
SKM1_Scer ------------------------------------------------------------
CLA4_Scer ------------------------------------------------------------
Pak3_Dmel ------------------------------------------------------------
Pak_Dmel ------------------------------------------------------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis ------------------------------------------------------------
PakB_Ddis ------------------------------------------------------------
PakC_Ddis ------------------------------------------------------------
PakD_Ddis LRACWLFGLHSKYFFPSSYLLSMTIENNDNSNSSKTTTNNNNNNNNNNNNNNNNNNNNNN
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur ------------------------------------------------------------
CC1G_15304_Ccin ------------------------------------------------------------
CC1G_00840_Ccin ------------------------------------------------EYHR--------
CC1G_02087_Ccin ------------------------------------------------------------
AqueK235_Aque ------------------------------------------------------------
GK081_Glam ------------------------------------------------------------
PAK3_Hsap ------------------------------------------------------------
PAK2_Hsap ------------------------------------------------------------
PAK1_Hsap ------------------------------------------------------------
PAK3_Mmus ------------------------------------------------------------
PAK2_Mmus ------------------------------------------------------------
PAK1_Mmus ------------------------------------------------------------
pak-1_Cele ------------------------------------------------------------
STE20_Scer GDGLR----LPRTTGTL-----------------------NVNALQKGTNAAH--E-AGG
SKM1_Scer ------------------------------------------------------------
CLA4_Scer ------------------------------------------------------------
Pak3_Dmel ------------------------------------------------------------
Pak_Dmel ------------------------------------------------------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis ------------------------------------------------------------
PakB_Ddis ------------------------------------------------------------
PakC_Ddis ------------------------------------------------------------
PakD_Ddis NNNNRAIITSPNKNGGVNTMIVNLEYKEKIMINLTELCKISLKIKNFGSFLQ-----LS-
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur ----------------------------------------HGPPKMSA-----QWSDPQ-
CC1G_15304_Ccin ------------------------------------------------------------
CC1G_00840_Ccin -PSR---------ESIQ-----------------------EYNALLADAN-LHAAE-AAK
CC1G_02087_Ccin ------------------------------------------------------------
AqueK235_Aque ------------------------------------------------------------
GK081_Glam ------------------------------------------------------------
PAK3_Hsap -DNEEKPP--------------------APPLRM--------NSN-----N---------
PAK2_Hsap -ELEDKPP--------------------APPVRM--------SSTIFSTGG---------
PAK1_Hsap -DIQDKPP--------------------APPMRN--------TSTMIGAGS---------
PAK3_Mmus -DNEEKPP--------------------APPLRM--------NSN-----N---------
PAK2_Mmus -ELEDKPP--------------------APPVRM--------SSTIFSTGG---------
PAK1_Mmus -DIQDKPP--------------------APPMRN--------TSTMIGAGS---------
pak-1_Cele -SYDEKPP--------------------APPIRF--------SSSATRE-----------
STE20_Scer Y-KSMDPA-KNAETTNDDDNNVVSLDDPIQFTRV--------SSSSVISGM---------
SKM1_Scer ---CNEEPVL------------------SVPLTS--------ITN---------------
CLA4_Scer -DFQNIGPAP------------------RPPSSN--------SQG---------------
Pak3_Dmel ------------------------------------------------------------
Pak_Dmel ---EDKPP--------------------APPVRL--------TSNRGGNER---------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis ----------------------------TPPPSV--------SSLRQKFEQFLDKTDKGF
PakB_Ddis -PPNRKP--P------------------PPNKRV--------QTNGTSSLN---------
PakC_Ddis -DKEERPV-G------------------AVPLRM--------SRCYENK-----------
PakD_Ddis -SSSSSTP--------------------PPPINN--------NNNNNNNNN---------
19075_Tthe ------------------------------------------------------------
25909_Tthe -EIQEGKP--------------------FNFQKH--------ISI---------------
PAK1_Spur -SYTDSPP--------------------APPVRV--------SSSNSRDAR---------
CC1G_15304_Ccin -SIASGLS--------------------SPPTEG--------KRPQSRGKE---------
CC1G_00840_Ccin YIPSRAPP--------------------PPPTNS--------QRAKTPTDQ---------
CC1G_02087_Ccin -SLQPTRPAP------------------QAPQRRNDAQPLYSSNNLLSSSG---------
AqueK235_Aque ----DDPP--------------------IPPIRN--------VSTRDKE-----------
GK081_Glam ------------------------------------------------------------
PAK3_Hsap ------------------------------------------------------------
PAK2_Hsap ------------------------------------------------------------
PAK1_Hsap ------------------------------------------------------------
PAK3_Mmus ------------------------------------------------------------
PAK2_Mmus ------------------------------------------------------------
PAK1_Mmus ------------------------------------------------------------
pak-1_Cele ------------------------------------------------------------
STE20_Scer ------------------------------------------S-----------------
SKM1_Scer ------------------------------------------------------------
CLA4_Scer ------------------------------------------------------------
Pak3_Dmel ------------------------------------------------------------
Pak_Dmel ------------------------------------------S-----------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis NATRNNYRGPVSSSTGIINDKEKKSHSYFKVREEGSNKRPSSFSASNPITPSSPQSTHSS
PakB_Ddis -------------------------------------SSGSSFVSPSPSPSPSPQQP---
PakC_Ddis ------------------------------------------------------------
PakD_Ddis ------------------------------------------NNNN--------------
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur ------------------------------------------F-----------------
CC1G_15304_Ccin ------------------------------------------------------------
CC1G_00840_Ccin ------------------------------------------Q-----------------
CC1G_02087_Ccin ------------------------------------------------------------
AqueK235_Aque ------------------------------------------------------------
GK081_Glam ------------------------------------------------------------
PAK3_Hsap ------------------------------------------------------------
PAK2_Hsap ------------------------------------------------------------
PAK1_Hsap ------------------------------------------------------------
PAK3_Mmus ------------------------------------------------------------
PAK2_Mmus ------------------------------------------------------------
PAK1_Mmus ------------------------------------------------------------
pak-1_Cele ------------------------------------------------------------
STE20_Scer ------------------------------------SSMSPHSNIDETKSLEAVTPNINT
SKM1_Scer ------------------------------------------------------------
CLA4_Scer ------------------------------------------------------------
Pak3_Dmel ------------------------------------------------------------
Pak_Dmel ------------------------------------G-----------------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis PIYRGVGYHQYSSVNSGNSYSGSGNNINNIINNSNNS-----------------------
PakB_Ddis ------------------------------------------------------------
PakC_Ddis ------------------------------------------------------------
PakD_Ddis --------------------------------------NNNDLLISNNSSN---------
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur ------------------------------------------------------------
CC1G_15304_Ccin ------------------------------------------------------------
CC1G_00840_Ccin ---------------------------------------------------------RTR
CC1G_02087_Ccin ------------------------------------------------------------
AqueK235_Aque ------------------------------------------------------------
GK081_Glam ------------------------------------------------------------
PAK3_Hsap ----------------------------R-------------------------------
PAK2_Hsap ----------------------------K-------------------------------
PAK1_Hsap ----------------------------K-------------------------------
PAK3_Mmus ----------------------------R-------------------------------
PAK2_Mmus ----------------------------K-------------------------------
PAK1_Mmus ----------------------------K-------------------------------
pak-1_Cele ------------------------------------------------------------
STE20_Scer SNITPDHSADNTFSTI---NASE-----S-------------------------------
SKM1_Scer ----------------------------V-------------------------------
CLA4_Scer ----------------------------R-------------------------------
Pak3_Dmel ------------------------------------------------------------
Pak_Dmel -------------GGV---GVGGGGLGGG-------------------------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis -------------NSNNLYGNNSNNQSSGSLGNFLIDKLEYSAATVTASDLKRERQQLFR
PakB_Ddis --------------------------------------------------VKR-------
PakC_Ddis ------------------------------------------------------------
PakD_Ddis ------------------------------------------------------------
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur ------------------------------------------------------------
CC1G_15304_Ccin ----------------------------K-------------------------------
CC1G_00840_Ccin S-------------SL--------------------------------------------
CC1G_02087_Ccin ----------------------------Y-------------------------------
AqueK235_Aque ------------------------------------------------------------
GK081_Glam ------------------------------------------------------------
PAK3_Hsap ------------------------------------------------------------
PAK2_Hsap ------------------------------------------------------------
PAK1_Hsap ------------------------------------------------------------
PAK3_Mmus ------------------------------------------------------------
PAK2_Mmus ------------------------------------------------------------
PAK1_Mmus ------------------------------------------------------------
pak-1_Cele ------------------------------------------------------------
STE20_Scer ------------------------------------------------------------
SKM1_Scer ------------------------------------------------------------
CLA4_Scer ------------------------------------------------------------
Pak3_Dmel ------------------------------------------------------------
Pak_Dmel ------------------------------------------------------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis NKEEFTMESSSYGGSTIGDDDLDSLNGSSSQQFNHRNSSWADRRERFIKKVMNGQFNEVQ
PakB_Ddis -------------PL---------------------------------------------
PakC_Ddis ------------------------------------------------------------
PakD_Ddis --------------------------ISSPNSFS--------------------------
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur ------------------------------------------------------------
CC1G_15304_Ccin ------------------------------------------------------------
CC1G_00840_Ccin ------------------------------------------------------------
CC1G_02087_Ccin ------------------------------------------------------------
AqueK235_Aque ------------------------------------------------------------
GK081_Glam ------------------------------------------------------------
PAK3_Hsap ------------------------------------------------------------
PAK2_Hsap ------------------------------------------------------------
PAK1_Hsap ------------------------------------------------------------
PAK3_Mmus ------------------------------------------------------------
PAK2_Mmus ------------------------------------------------------------
PAK1_Mmus ------------------------------------------------------------
pak-1_Cele ------------------------------------------------------------
STE20_Scer -----------------------------------------------------DHQFNDT
SKM1_Scer ------------------------------------------------------------
CLA4_Scer ------------------------------------------------------------
Pak3_Dmel ------------------------------------------------------------
Pak_Dmel ------------------------------------------------------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis MRDELNRLRDIEADKIRAEERRTPSMNMDEFKAIEIERLRKKIYQEELVIFRQEEIEKIQ
PakB_Ddis ------------------------------------------------PSPG--------
PakC_Ddis ------------------------------------------------------------
PakD_Ddis ------------------------------------------------------------
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur ------------------------------------------------------------
CC1G_15304_Ccin ------------------------------------------------------------
CC1G_00840_Ccin ------------------------------------------------------------
CC1G_02087_Ccin ------------------------------------------------------------
AqueK235_Aque ------------------------------------------------------------
GK081_Glam ------------------------------------------------------------
PAK3_Hsap ------------------------------------------------------------
PAK2_Hsap ------------------------------------------------------------
PAK1_Hsap ------------------------------------------------------------
PAK3_Mmus ------------------------------------------------------------
PAK2_Mmus ------------------------------------------------------------
PAK1_Mmus ------------------------------------------------------------
pak-1_Cele ------------------------------------------------------------
STE20_Scer LLSKLSLTDSTETIENNATVKHQQPVASSTVNSNKSSTDIRRATPVSTPVISKPSMT---
SKM1_Scer ------------------------------------------------------------
CLA4_Scer ------------------------------------------------------------
Pak3_Dmel ------------------------------------------------------------
Pak_Dmel ------------------------------------------------------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis REERIKIEKEYDDKSIISSQERQHIVQQIINQKEDEKGSSPPFPI---------------
PakB_Ddis -----------------------------------VNKQAPPALPTQPRPQQQQPEIPVR
PakC_Ddis ------------------------------------------------------------
PakD_Ddis --------------------------------------DS----PM--------------
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur ------------------------------------------------------------
CC1G_15304_Ccin ------------------------------------------------------------
CC1G_00840_Ccin -LHKQNPRARNHS---LSSQPHHDPFA-ANVNSQE-SSFVPPPSPMATHIYNKPPNGTSP
CC1G_02087_Ccin ------------------------------------------------------------
AqueK235_Aque ------------------------------------------------------------
GK081_Glam ------------------------------------------------------------
PAK3_Hsap ------------------------------------------------------------
PAK2_Hsap ------------------------------------------------------------
PAK1_Hsap ------------------------------------------------------------
PAK3_Mmus ------------------------------------------------------------
PAK2_Mmus ------------------------------------------------------------
PAK1_Mmus ------------------------------------------------------------
pak-1_Cele ------------------------------------------------------------
STE20_Scer -TTPR-------------------------------------------------------
SKM1_Scer ------------------------------------------------------------
CLA4_Scer ------------------------------------------------------------
Pak3_Dmel ------------------------------------------------------------
Pak_Dmel ------------------------------------------------------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis ---PLVVNNNNNENNENDNNNNNNNNNNNNNNNNNNNNNNNKNIDLTSFNNNININSNNN
PakB_Ddis PTTPT-------------------------------------------------------
PakC_Ddis ------------------------------------------------------------
PakD_Ddis ------------------------------------------------------------
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur ------------------------------------------------------------
CC1G_15304_Ccin ------------------------------------------------------------
CC1G_00840_Ccin PPRPS-------------------------------------------------------
CC1G_02087_Ccin ------------------------------------------------------------
AqueK235_Aque ------------------------------------------------------------
GK081_Glam ------------------------------------------------------------
PAK3_Hsap ------------------------------------------------------------
PAK2_Hsap ------------------------------------------------------------
PAK1_Hsap ------------------------------------------------------------
PAK3_Mmus ------------------------------------------------------------
PAK2_Mmus ------------------------------------------------------------
PAK1_Mmus ------------------------------------------------------------
pak-1_Cele ------------------------------------------------------------
STE20_Scer ------------------------------------------------------------
SKM1_Scer ------------------------------------------------------------
CLA4_Scer ------------------------------------------------------------
Pak3_Dmel ------------------------------------------------------------
Pak_Dmel ------------------------------------------------------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis EIKNNVIVDSDDEEELERLEQLRRQREIERLREEEEENEDRVERELASRRRQEEDRIKRE
PakB_Ddis ------------------------------------------------------------
PakC_Ddis ------------------------------------------------------------
PakD_Ddis ------------------------------------------------------------
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur ------------------------------------------------------------
CC1G_15304_Ccin ------------------------------------------------------------
CC1G_00840_Ccin ------------------------------------------------------------
CC1G_02087_Ccin ------------------------------------------------------------
AqueK235_Aque ------------------------------------------------------------
GK081_Glam ------------------------------------------------------------
PAK3_Hsap ------------------------------------------------------------
PAK2_Hsap ------------------------------------------------------------
PAK1_Hsap ------------------------------------------------------------
PAK3_Mmus ------------------------------------------------------------
PAK2_Mmus ------------------------------------------------------------
PAK1_Mmus ------------------------------------------------------------
pak-1_Cele ------------------------------------------------------------
STE20_Scer ---------------------------------------------------QINSASHS-
SKM1_Scer ------------------------------------------------------------
CLA4_Scer ------------------------------------------------------------
Pak3_Dmel ------------------------------------------------------------
Pak_Dmel ------------------------------------------------------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis EEEEEEEQRNYLRRLKELERIKQIEEEEEEERERQSQLQSSQQQQKSSSTQRSSNTVTST
PakB_Ddis ---------------------------------------------------RTPPNLINS
PakC_Ddis ------------------------------------------------------------
PakD_Ddis ---------------------------------------------------GFSSSINSS
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur ------------------------------------------------------------
CC1G_15304_Ccin ------------------------------------------------------------
CC1G_00840_Ccin ---------------------------------------------------RANTANLTD
CC1G_02087_Ccin ------------------------------------------------------------
AqueK235_Aque ------------------------------------------------------------
GK081_Glam ------------------------------------------------------------
PAK3_Hsap -------------------------------------DS---------------------
PAK2_Hsap -------------------------------------DP---------------------
PAK1_Hsap -------------------------------------DA---------------------
PAK3_Mmus -------------------------------------DS---------------------
PAK2_Mmus -------------------------------------DP---------------------
PAK1_Mmus -------------------------------------DT---------------------
pak-1_Cele ------------------------------------------------------------
STE20_Scer -------------------------------L--S--NP---------------------
SKM1_Scer -------------------------------------SR---------------------
CLA4_Scer -------------------------------------TC---------------------
Pak3_Dmel ------------------------------------------------------------
Pak_Dmel -------------------------------------GM---------------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis -------SSSSTG-----------------------------------------------
PakB_Ddis NGTSGGSGFSSSSGNSGYSSSNNNNSNSNSSINMNGNHS---------------------
PakC_Ddis ------------------------------------------------------------
PakD_Ddis SN----------------------------------NSNLNTPNNYNNTNNNNNNNNNNN
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur ------------------------------------------------------------
CC1G_15304_Ccin -------------------------------------AL---------------------
CC1G_00840_Ccin IFPTQSQLAARRLSTPSAAPQVHEDGRFYADPNEA--MP---------------------
CC1G_02087_Ccin -------------------------------------NP---------------------
AqueK235_Aque ------------------------------------------------------------
GK081_Glam ------------------------------------------------------------
PAK3_Hsap ------------------SALNH-------------------------------------
PAK2_Hsap ------------------LSANH-------------------------------------
PAK1_Hsap ------------------GTLNH-------------------------------------
PAK3_Mmus ------------------SALNH-------------------------------------
PAK2_Mmus ------------------LSANH-------------------------------------
PAK1_Mmus ------------------GTLNH-------------------------------------
pak-1_Cele -------------------NQVV-------------------------------------
STE20_Scer ------------------KHKQH-------------------------------------
SKM1_Scer ------------------IQLKQ-------------------------------------
CLA4_Scer ------------------Y---N-------------------------------------
Pak3_Dmel ------------------------------------------------------------
Pak_Dmel ------------------GDVPP-------------------------------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis -----------------------GDSNPSTSQKPTNLLNLMGSNNNISNINTNILSHSIV
PakB_Ddis ------------------NGLNGGSSNPVPMRKVSSPIN---------------------
PakC_Ddis -------------------SLG--------------------------------------
PakD_Ddis NNNNNNINNLTPQMIISSPTSTS-------------------------------------
19075_Tthe ------------------------------------------------------------
25909_Tthe -------------------QVDQ-------------------------------------
PAK1_Spur ------------------DNMNP-------------------------------------
CC1G_15304_Ccin ------------------SFLKF-------------------------------------
CC1G_00840_Ccin ------------------HNQNM-------------------------------------
CC1G_02087_Ccin ------------------SFAYS-------------------------------------
AqueK235_Aque -------------------PAKN-------------------------------------
GK081_Glam ------------------------------------------------------------
PAK3_Hsap ------------------------------------------------------------
PAK2_Hsap ------------------------------------------------------------
PAK1_Hsap ------------------------------------------------------------
PAK3_Mmus ------------------------------------------------------------
PAK2_Mmus ------------------------------------------------------------
PAK1_Mmus ------------------------------------------------------------
pak-1_Cele ------------------------------------------------------------
STE20_Scer ------------------------------------------------------------
SKM1_Scer ------------------------------------------------------------
CLA4_Scer ------------------------------------------------------------
Pak3_Dmel ------------------------------------------------------------
Pak_Dmel ------------------------------------------------------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis NS-SGGLPPPPPTASHVDNRS-----RSHTLAGESHSSENTPLVSSIDNNGVNNKMSRSH
PakB_Ddis -IANGTTPPPPPQPTPSQQPQQSPSSAS-----HNNTQH---------------------
PakC_Ddis ------------------------------------------------------------
PakD_Ddis ------------------------------------------------------------
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur ------------------------------------------------------------
CC1G_15304_Ccin ------------------------------------------------------------
CC1G_00840_Ccin ------------------------------------------------------------
CC1G_02087_Ccin ------------------------------------------------------------
AqueK235_Aque ------------------------------------------------------------
GK081_Glam ------------------------------------------------------------
PAK3_Hsap -----------SSKPLPM------------------------------------------
PAK2_Hsap -----------SLKPLPS------------------------------------------
PAK1_Hsap -----------GSKPLPP------------------------------------------
PAK3_Mmus -----------SSKPLPM------------------------------------------
PAK2_Mmus -----------SLKPLPS------------------------------------------
PAK1_Mmus -----------GSKPLPP------------------------------------------
pak-1_Cele -----------GLKPLPK------------------------------------------
STE20_Scer -----------KPKVKPS------------------------------------------
SKM1_Scer -----------NCFEILR----------------------ATD---Q----KE-------
CLA4_Scer -----------QTQPITK----LMSQLDLTSASHLGT---STS---K----KKSGWVSYK
Pak3_Dmel ------------------------------------------------------------
Pak_Dmel -----------DMRPLPK------------------------------------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis SGGALSGLALPTAPPLPNQPNVNNSNNNNNNNNINNNHNHSHNHSNNLHQSALKNSSSMS
PakB_Ddis --------NIPSPPPLPNNKP---KKLAPTAVPAGLGSIIGGPKTPAISPGSTSP-----
PakC_Ddis -------------K--PNCFE---------------------------------------
PakD_Ddis -----------STPPLPP------------------------------------------
19075_Tthe ------------------------------------------------------------
25909_Tthe -----------NG-KLIN------------------------------------------
PAK1_Spur -----------GSKPLPN------------------------------------------
CC1G_15304_Ccin -----------G-KRSPK------------------------------------------
CC1G_00840_Ccin -----------NDYPLPP------------------------------------------
CC1G_02087_Ccin -----------SSTPINQ----NYSQS----YSGIGGTPNRGADDTMNQQIVRNGSVSMK
AqueK235_Aque -----------GSRPV--------------------------------------------
GK081_Glam ------------------------------------------------------------
PAK3_Hsap ------------------------------------------------------------
PAK2_Hsap ------------------------------------------------------------
PAK1_Hsap ------------------------------------------------------------
PAK3_Mmus ------------------------------------------------------------
PAK2_Mmus ------------------------------------------------------------
PAK1_Mmus ------------------------------------------------------------
pak-1_Cele ------------------------------------------------------------
STE20_Scer ------------------------------------------------------------
SKM1_Scer ------------------------------------------------------------
CLA4_Scer DDGILSFIWQKRYLMLHDSYVALYKNDKQNDDAILKIPLTSIISVSRTQLKQYCFELVRC
Pak3_Dmel ------------------------------------------------------------
Pak_Dmel ------------------------------------------------------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis TPSISPSQAGNSATSTVPSSPISASTSMSSPTL------VVSPRKDELTTSTGSTRKGSI
PakB_Ddis -----------SLGSSNGNIPISTTSTPITPTPPISVPLATSPNNSH-------------
PakC_Ddis ------------------------------------------------------------
PakD_Ddis ------------------------------------------------------------
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur ------------------------------------------------------------
CC1G_15304_Ccin ------------------------------------------------------------
CC1G_00840_Ccin ------------------------------------------------------------
CC1G_02087_Ccin EDGFGNWLWQRKWLILREQALTIHKNENSPHQT--MILLRDISNIERTDLKPYCL-----
AqueK235_Aque ------------------------------------------------------------
GK081_Glam ------------------------------------------------------------
PAK3_Hsap ------------------------------------------------------------
PAK2_Hsap ------------------------------------------------------------
PAK1_Hsap ------------------------------------------------------------
PAK3_Mmus ------------------------------------------------------------
PAK2_Mmus ------------------------------------------------------------
PAK1_Mmus ------------------------------------------------------------
pak-1_Cele ------------------------------------------------------------
STE20_Scer ------------------------------------------------------------
SKM1_Scer ----NIS-----P-----------------------------------------------
CLA4_Scer SDRNSVSSGSSSS-----------------------------------------------
Pak3_Dmel ------------------------------------------------------------
Pak_Dmel ------------------------------------------------------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis SEREDKKKVSSSSTSSSSSSNGGLSSSGKDHKKD--------------------------
PakB_Ddis -------------------------------KDSISNSNSNNNNNNNNNNNNNSSNATTS
PakC_Ddis ------------------------------------------------------------
PakD_Ddis ------------------------------------------------------------
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur ------------------------------------------------------------
CC1G_15304_Ccin ------------------------------------------------------------
CC1G_00840_Ccin ------------------------------------------------------------
CC1G_02087_Ccin ------------------------------------------------------------
AqueK235_Aque ------------------------------------------------------------
GK081_Glam ------------------------------------------------------------
PAK3_Hsap --------APEEKNK-KARL-RSIFPGG---GD---------------------------
PAK2_Hsap --------VPEEKKP-RHKI-ISIFSG----TE---------------------------
PAK1_Hsap --------NPEEKKK-KDRFYRSILPG-----D---------------------------
PAK3_Mmus --------APEEKNK-KARL-RSIFPGG---GD---------------------------
PAK2_Mmus --------VPEEKKP-RNKI-ISIFSG----TE---------------------------
PAK1_Mmus --------NPEEKKK-KDRFYRSILPG-----D---------------------------
pak-1_Cele --------EPEATKK-KKTM-PNPFMK----KN---------------------------
STE20_Scer --------KPEAKSK-PVSV-KKSFPSKNPLKNS--------------------------
SKM1_Scer -----INSYFYESNS-KRSIF----IS-----T---------------------------
CLA4_Scer -----LNV-SSDSNS-KKSIY----IA-----T---------------------------
Pak3_Dmel ------------------------------------------------------------
Pak_Dmel --------EPDDSDR-KKKTLKSKIKG-----S---------------------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis -------HSSEEKEKEKKSFFNKLFSK-----E---------------------------
PakB_Ddis PPSPPVSNVGNKQDEEKKGFL-SIFTN---------------------------------
PakC_Ddis ---LV------SPRINKTFFIQANTPD-----E---------------------------
PakD_Ddis --------CANNINN-NNLKKRTKIPKNNNN-NNNNNNNNNNNNNNNNNNNNNNNNNNKI
19075_Tthe -------------------K-INYDRKK---TI---------------------------
25909_Tthe --------VPEEWKK-YGLG-LDIDETK---TV---------------------------
PAK1_Spur --------TPPEEQKKGPKWMKNILKG-----G---------------------------
CC1G_15304_Ccin --------SPPTKDAS---W-DSAVPP---------------------------------
CC1G_00840_Ccin --------PPPPSAPLPARV-RS--------GT---------------------------
CC1G_02087_Ccin --------L-LETKD-KR-YF----LS-----L---------------------------
AqueK235_Aque -------------DKK-A----GFFKK-----D---------------------------
GK081_Glam ------------------------------------------------------------
PAK3_Hsap ------------------------------------------------------------
PAK2_Hsap ------------------------------------------------------------
PAK1_Hsap ------------------------------------------------------------
PAK3_Mmus ------------------------------------------------------------
PAK2_Mmus ------------------------------------------------------------
PAK1_Mmus ------------------------------------------------------------
pak-1_Cele ------------------------------------------------------------
STE20_Scer ------------------------------------------------------------
SKM1_Scer ------------------------------------------------------------
CLA4_Scer ------------------------------------------------------------
Pak3_Dmel ------------------------------------------------------------
Pak_Dmel ------------------------------------------------------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis ------------------------------------------------------------
PakB_Ddis ------------------------------------------------------------
PakC_Ddis ------------------------------------------------------------
PakD_Ddis IIKRDCKKVYRKRKSSNCDNDDNGSNSDSDSSDSSDSSDSDSDSLLSSDGTPIILSQSSN
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur ------------------------------------------------------------
CC1G_15304_Ccin ------------------------------------------------------------
CC1G_00840_Ccin ------------------------------------------------------------
CC1G_02087_Ccin ------------------------------------------------------------
AqueK235_Aque ------------------------------------------------------------
GK081_Glam ------------------------------------------------------------
PAK3_Hsap --------------------------------------------K---------------
PAK2_Hsap --------------------------------------------K---------------
PAK1_Hsap --------------------------------------------K---------------
PAK3_Mmus --------------------------------------------K---------------
PAK2_Mmus --------------------------------------------K---------------
PAK1_Mmus --------------------------------------------K---------------
pak-1_Cele --------------------------------------------K---------------
STE20_Scer -------------------------------------------SP---------PKKQTE
SKM1_Scer --------------------------------------------R---------TERD--
CLA4_Scer --------------------------------------------K---------TESD--
Pak3_Dmel ------------------------------------------------------------
Pak_Dmel --------------------------------------------K---------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis --------------------------------------------K---------KD----
PakB_Ddis ------------------------------------------------------------
PakC_Ddis --------------------------------------------M---------------
PakD_Ddis PESVSFKSFIKEILHLKNIISKQDKTITSQKQTIETLEKDLEFQ------------KQLT
19075_Tthe --------------------------------------------VTKNFPKSVR-ASK--
25909_Tthe --------------------------------------------KTKKMPEVVRFENE--
PAK1_Spur --------------------------------------------K---------------
CC1G_15304_Ccin ------------------------------------------------------------
CC1G_00840_Ccin --------------------------------------------K---------SKKG--
CC1G_02087_Ccin --------------------------------------------K---------NDEE--
AqueK235_Aque --------------------------------------------K---------------
GK081_Glam --------------------------------------------K---------------
PAK3_Hsap ------------------------------------------------------------
PAK2_Hsap ------------------------------------------------------------
PAK1_Hsap ------------------------------------------------------------
PAK3_Mmus ------------------------------------------------------------
PAK2_Mmus ------------------------------------------------------------
PAK1_Mmus ------------------------------------------------------------
pak-1_Cele ------------------------------------------------------------
STE20_Scer KSYY-------------SS-----------------------------------------
SKM1_Scer ------------------------------------------------------------
CLA4_Scer ------------------------------------------------------------
Pak3_Dmel ------------------------------------------------------------
Pak_Dmel ------------------------------------------------------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis ------------------------------------------------------------
PakB_Ddis ------------------------------------------------------------
PakC_Ddis ------------------------------------------------------------
PakD_Ddis KKLLSSPIDLSNFIETSSDPNGAIPVSIQAFTRQIQQIQTLQQQNLSLETELSKTNEHLS
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur ------------------------------------------------------------
CC1G_15304_Ccin ------------------------------------------------------------
CC1G_00840_Ccin ------------------------------------------------------------
CC1G_02087_Ccin ------------------------------------------------------------
AqueK235_Aque ------------------------------------------------------------
GK081_Glam ------------------------------------------------------------
PAK3_Hsap ------------------------------------------------------------
PAK2_Hsap ------------------------------------------------------------
PAK1_Hsap ------------------------------------------------------------
PAK3_Mmus ------------------------------------------------------------
PAK2_Mmus ------------------------------------------------------------
PAK1_Mmus ------------------------------------------------------------
pak-1_Cele ------------------------------------------------------------
STE20_Scer ------SSKKRKSGSNSGTLRMKDVFTS-F------------------------------
SKM1_Scer -----------L--------------HG-W------------------------------
CLA4_Scer -----------L--------------HS-W------------------------------
Pak3_Dmel ------------------------------------------------------------
Pak_Dmel ------------------------------------------------------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis -------------HHSSSKSPSSGSSGGGE------------------------------
PakB_Ddis -----------------------------K------------------------------
PakC_Ddis --------------------------AS-W------------------------------
PakD_Ddis TNIRKNS------------KLENEV-LS-IETELLNLRMKYANTLSSSNSNGNNNSNNNS
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur ------------------------------------------------------------
CC1G_15304_Ccin ------------------------------------------------------------
CC1G_00840_Ccin -----------V--------------LG-F------------------------------
CC1G_02087_Ccin -----------L--------------YG-W------------------------------
AqueK235_Aque ------------------------------------------------------------
GK081_Glam ------------------------------------------------------------
PAK3_Hsap ------------------------------------------------------------
PAK2_Hsap ------------------------------------------------------------
PAK1_Hsap ------------------------------------------------------------
PAK3_Mmus ------------------------------------------------------------
PAK2_Mmus ------------------------------------------------------------
PAK1_Mmus ------------------------------------------------------------
pak-1_Cele ------------------------------------------------------------
STE20_Scer ------------------------------------------------------------
SKM1_Scer ------------------------------------------------------------
CLA4_Scer ------------------------------------------------------------
Pak3_Dmel ------------------------------------------------------------
Pak_Dmel ------------------------------------------------------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis ------------------------------------------------------------
PakB_Ddis ------------------------------------------------------------
PakC_Ddis ------------------------------------------------------------
PakD_Ddis LGCNNSINGSSSGGGGNNSSTSKGTLSRTISQPFPLRKSISHSNIITSPVNSHQQQQQQN
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur ------------------------------------------------------------
CC1G_15304_Ccin ------------------------------------------------------------
CC1G_00840_Ccin ------------------------------------------------------------
CC1G_02087_Ccin ------------------------------------------------------------
AqueK235_Aque ------------------------------------------------------------
GK081_Glam ------------------------------------------------------------
PAK3_Hsap ------------------------------------------------------------
PAK2_Hsap ------------------------------------------------------------
PAK1_Hsap ------------------------------------------------------------
PAK3_Mmus ------------------------------------------------------------
PAK2_Mmus ------------------------------------------------------------
PAK1_Mmus ------------------------------------------------------------
pak-1_Cele ------------------------------------------------------------
STE20_Scer ------------------------------------------------------------
SKM1_Scer ------------------------------------------------------------
CLA4_Scer ------------------------------------------------------------
Pak3_Dmel ------------------------------------------------------------
Pak_Dmel ------------------------------------------------------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis ------------------------------------------------------------
PakB_Ddis ------------------------------------------------------------
PakC_Ddis ------------------------------------------------------------
PakD_Ddis QLSQSQTTSPKNTSASYNNGILSKSSIVSNTNTNSTYKFGSSTGILKVSATLQQKQQQQQ
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur ------------------------------------------------------------
CC1G_15304_Ccin ------------------------------------------------------------
CC1G_00840_Ccin ------------------------------------------------------------
CC1G_02087_Ccin ------------------------------------------------------------
AqueK235_Aque ------------------------------------------------------------
GK081_Glam ------------------------------------------------------------
PAK3_Hsap ------------------------------------------------------------
PAK2_Hsap ------------------------------------------------------------
PAK1_Hsap ------------------------------------------------------------
PAK3_Mmus ------------------------------------------------------------
PAK2_Mmus ------------------------------------------------------------
PAK1_Mmus ------------------------------------------------------------
pak-1_Cele ------------------------------------------------------------
STE20_Scer ------------------------------------------------------------
SKM1_Scer ------------------------------------------------------------
CLA4_Scer ------------------------------------------------------------
Pak3_Dmel ------------------------------------------------------------
Pak_Dmel ------------------------------------------------------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis ------------------------------------------------------------
PakB_Ddis ------------------------------------------------------------
PakC_Ddis ------------------------------------------------------------
PakD_Ddis QQQNQQQQQNQQQQQQNQQQQNQQQQNQQKQNQQQQNQQQQQQQQQQQQQNQQQQQQQQQ
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur ------------------------------------------------------------
CC1G_15304_Ccin ------------------------------------------------------------
CC1G_00840_Ccin ------------------------------------------------------------
CC1G_02087_Ccin ------------------------------------------------------------
AqueK235_Aque ------------------------------------------------------------
GK081_Glam ------------------------------------------------------------
PAK3_Hsap ------------------------------------------------------------
PAK2_Hsap ------------------------------------------------------------
PAK1_Hsap ------------------------------------------------------------
PAK3_Mmus ------------------------------------------------------------
PAK2_Mmus ------------------------------------------------------------
PAK1_Mmus ------------------------------------------------------------
pak-1_Cele ------------------------------------------------------------
STE20_Scer ------------------------------------------------------------
SKM1_Scer ------------------------------------------------------------
CLA4_Scer ------------------------------------------------------------
Pak3_Dmel ------------------------------------------------------------
Pak_Dmel ------------------------------------------------------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis ------------------------------------------------------------
PakB_Ddis ------------------------------------------------------------
PakC_Ddis ------------------------------------------------------------
PakD_Ddis QQQQQQQQQNQQQQQNNQLSQSQQLQQQQNQQINNLIDSPLIISNSSNQQIESESIESDS
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur ------------------------------------------------------------
CC1G_15304_Ccin ------------------------------------------------------------
CC1G_00840_Ccin ------------------------------------------------------------
CC1G_02087_Ccin ------------------------------------------------------------
AqueK235_Aque ------------------------------------------------------------
GK081_Glam ------------------------------------------------------------
PAK3_Hsap ------------------------------------------------------------
PAK2_Hsap ------------------------------------------------------------
PAK1_Hsap ------------------------------------------------------------
PAK3_Mmus ------------------------------------------------------------
PAK2_Mmus ------------------------------------------------------------
PAK1_Mmus ------------------------------------------------------------
pak-1_Cele ------------------------------------------------------------
STE20_Scer ------------------------------------------------------------
SKM1_Scer ------------------------------------------------------------
CLA4_Scer ------------------------------------------------------------
Pak3_Dmel ------------------------------------------------------------
Pak_Dmel ------------------------------------------------------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis ------------------------------------------------------------
PakB_Ddis ------------------------------------------------------------
PakC_Ddis ------------------------------------------------------------
PakD_Ddis DYDKDMVDFGKKIVSALISSSNHVEMSEIYKMNDILTNETSRRQICIVLEEETKINQLKL
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur ------------------------------------------------------------
CC1G_15304_Ccin ------------------------------------------------------------
CC1G_00840_Ccin ------------------------------------------------------------
CC1G_02087_Ccin ------------------------------------------------------------
AqueK235_Aque ------------------------------------------------------------
GK081_Glam ------------------------------------------------------------
PAK3_Hsap ------------------------------------------------------------
PAK2_Hsap ------------------------------------------------------------
PAK1_Hsap ------------------------------------------------------------
PAK3_Mmus ------------------------------------------------------------
PAK2_Mmus ------------------------------------------------------------
PAK1_Mmus ------------------------------------------------------------
pak-1_Cele ------------------------------------------------------------
STE20_Scer ------------------------------------------------------------
SKM1_Scer ------------------------------------------------------------
CLA4_Scer ------------------------------------------------------------
Pak3_Dmel ------------------------------------------------------------
Pak_Dmel ------------------------------------------------------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis ------------------------------------------------------------
PakB_Ddis ------------------------------------------------------------
PakC_Ddis ------------------------------------------------------------
PakD_Ddis PMNENSFEVTLYLVNTILQCIHEAPSKDYFSLKLIMESSRILNRKKVNGSCEFIQEFIKD
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur ------------------------------------------------------------
CC1G_15304_Ccin ------------------------------------------------------------
CC1G_00840_Ccin ------------------------------------------------------------
CC1G_02087_Ccin ------------------------------------------------------------
AqueK235_Aque ------------------------------------------------------------
GK081_Glam ------------------------------------------------------------
PAK3_Hsap ------------------------------------------------------------
PAK2_Hsap ------------------------------------------------------------
PAK1_Hsap ------------------------------------------------------------
PAK3_Mmus ------------------------------------------------------------
PAK2_Mmus ------------------------------------------------------------
PAK1_Mmus ------------------------------------------------------------
pak-1_Cele ------------------------------------------------------------
STE20_Scer ------------------------------------------------------------
SKM1_Scer ------------------------------------------------------------
CLA4_Scer ------------------------------------------------------------
Pak3_Dmel ------------------------------------------------------------
Pak_Dmel ------------------------------------------------------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis ------------------------------------------------------------
PakB_Ddis ------------------------------------------------------------
PakC_Ddis ------------------------------------------------------------
PakD_Ddis HPTWKDIKFWEEQYWDELIIKHQQFSGSGSSSSSNTGGSIVTTMTTTTTVTSAITSSSST
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur ------------------------------------------------------------
CC1G_15304_Ccin ------------------------------------------------------------
CC1G_00840_Ccin ------------------------------------------------------------
CC1G_02087_Ccin ------------------------------------------------------------
AqueK235_Aque ------------------------------------------------------------
GK081_Glam ------------------------------------------------------------
PAK3_Hsap ------------------------------------------------------------
PAK2_Hsap ------------------------------------------------------------
PAK1_Hsap ------------------------------------------------------------
PAK3_Mmus ------------------------------------------------------------
PAK2_Mmus ------------------------------------------------------------
PAK1_Mmus ------------------------------------------------------------
pak-1_Cele ------------------------------------------------------------
STE20_Scer -------------------------------------------------------VQN--
SKM1_Scer -------------------------------------------------------L----
CLA4_Scer -------------------------------------------------------L----
Pak3_Dmel ------------------------------------------------------------
Pak_Dmel ------------------------------------------------------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis -------------------------------------------------------V----
PakB_Ddis -------------------------------------------------------K----
PakC_Ddis -------------------------------------------------------M----
PakD_Ddis TSDDFDVDYTELVNTLLISYVYNLASWGLSKSDVKEFTISMSKKSFLKSNELEKLIEQVT
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur ------------------------------------------------------------
CC1G_15304_Ccin ------------------------------------------------------------
CC1G_00840_Ccin -------------------------------------------------------M----
CC1G_02087_Ccin -------------------------------------------------------Q----
AqueK235_Aque ------------------------------------------------------------
GK081_Glam ------------------------------------------------------------
PAK3_Hsap ------------------------------------------------------------
PAK2_Hsap ------------------------------------------------------------
PAK1_Hsap ------------------------------------------------------------
PAK3_Mmus ------------------------------------------------------------
PAK2_Mmus ------------------------------------------------------------
PAK1_Mmus ------------------------------------------------------------
pak-1_Cele ------------------------------------------------------------
STE20_Scer --------------------------------------------------------IKRN
SKM1_Scer ------------------------------------------------------------
CLA4_Scer ------------------------------------------------------------
Pak3_Dmel ------------------------------------------------------------
Pak_Dmel ------------------------------------------------------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis ------------------------------------------------------------
PakB_Ddis ------------------------------------------------------------
PakC_Ddis ------------------------------------------------------------
PakD_Ddis STVELSFTSDHNVCKGPHSFVLKSFRIISECNYCRQYIWGVRGIVAREAFECVGCKYKTH
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur ------------------------------------------------------------
CC1G_15304_Ccin ------------------------------------------------------------
CC1G_00840_Ccin ------------------------------------------------------------
CC1G_02087_Ccin ------------------------------------------------------------
AqueK235_Aque ------------------------------------------------------------
GK081_Glam ------------------------------------------------------------
PAK3_Hsap -------------T----NK-KKEKERPEISLPSDFEHTIHVGFDA--VT-GEFTNSPFQ
PAK2_Hsap -------------G----SK-KKEKERPEISPPSDFEHTIHVGFDA--VT-GEFT-----
PAK1_Hsap -------------T----NK-KKEKERPEISLPSDFEHTIHVGFDA--VT-GEFT-----
PAK3_Mmus -------------T----NK-KKEKERPEISLPSDFEHTIHVGFDA--VT-GEFTNSPFQ
PAK2_Mmus -------------G----SK-KKEKERPEISPPSDFEHTIHVGFDA--VT-GEFT-----
PAK1_Mmus -------------T----NK-KKEKERPEISLPSDFEHTIHVGFDA--VT-GEFT-----
pak-1_Cele ------------------DK-KEASEKPVISRPSNFEHTIHVGYDP--KT-GEFT-----
STE20_Scer SQDDKRASSSSNNS----SS-SSITTALRISTPYNAKHIHHVGVDS--KT-GEYT-----
SKM1_Scer -------------D----AIFAKCPLLSGVSSPTNFTHKVHVGFDP--KV-GNFV-----
CLA4_Scer -------------D----AIFAKCPLLSGVSSPTNFTHKVHVGFDP--ET-GSFV-----
Pak3_Dmel -------------K----KG-GDGGSISEIGAPTNFQRHFHVSRNQ--ET-GDLE-----
Pak_Dmel -------------P-------SHTDSKPNISYPTNFEHTVHVGFDA--VT-GEFT-----
Y38F1A.10_Cele -------------Y----DW-WNDTT----------------------------------
PakA_Ddis -------------D----EK-KKKKLSPRVGTPFNVKHDVHVNFNA--DT-G-FE-----
PakB_Ddis -------------K----NK-DKK-KEFSVGSPFNVKHNIHVNYHS--VT-G-FE-----
PakC_Ddis -------------K----AV-EKGSEYSTVSQPFNLKHEVHVDFNS--AT-G-FS-----
PakD_Ddis KKCL-------KEA----SE-KTFCSSPNVGAPFNVKHEMHVGLA--------IQ-----
19075_Tthe -------------LPKEI-----------IDLITGVSLTPETNYSPLYSSQYTAE-----
25909_Tthe -------------LPENIQE-LISMLSLTVSKPENFARVHHIEIDP--SAPYGLK-----
PAK1_Spur -------------S----DE-KGQRTRPEISLPTKFEHTVHVGFDN--IT-GEFT-----
CC1G_15304_Ccin ---------------------LPSNGDDGISTPFNFQHNIHVNE--------GLV-----
CC1G_00840_Ccin -------------S----EV-FNPTKRPEISTPYDPVHLTHVGFNS--ST-GEFT-----
CC1G_02087_Ccin -------------D----DV-YSRSPLMGFSNPTNFVHKVHVGFDP--VS-GAFT-----
AqueK235_Aque -------------K----S--AGDSKKLEISSPTGFEHTVHVGFDP--VS-GEFT-----
GK081_Glam -------------N----AF-NEQIESSSISQPFDLKRGISVRYDP--QT-GKFT-----
PAK3_Hsap TSRPVTVASSQSEGKMPDLYGSQMCPGKLPEGIPEQWARL--LQTSNITKLEQK------
PAK2_Hsap -------------------------------GMPEQWARL--LQTSNITKLEQK------
PAK1_Hsap -------------------------------GMPEQWARL--LQTSNITKSEQK------
PAK3_Mmus TSRPVTVASSQSEGKMPDLYGSQMCPGKLPEGIPEQWARL--LQTSNITKLEQK------
PAK2_Mmus -------------------------------GMPEQWARL--LQTSNITKLEQK------
PAK1_Mmus -------------------------------GMPEQWARL--LQTSNITKSEQK------
pak-1_Cele -------------------------------GMPEAWARL--LTDSQISKQEQQ------
STE20_Scer -------------------------------GLPEEWEKL--LTSSGISKREQQ------
SKM1_Scer -------------------------------GVPDSWAKL--LQTSEITYDDWN------
CLA4_Scer -------------------------------GMPTNWEKL--LKHSRITGEDWN------
Pak3_Dmel -------------------------------GLPAPWVRL--M-NSQITRDEQD------
Pak_Dmel -------------------------------GMPEAWARL--LMNSNISKQEQK------
Y38F1A.10_Cele ----------------------------------------------------KP------
PakA_Ddis -------------------------------GLPKEWEVL--IK-SNFQEPEVM------
PakB_Ddis -------------------------------GLPKEWEVI--LQSSGITREDVV------
PakC_Ddis -------------------------------GLPKEWEVI--LKSSNVSKQEVL------
PakD_Ddis -------------------------------GLPSGWRTL--LLQSGFQDYEIQ------
19075_Tthe -------------------------------KITQEWDEI--VRENEQSKAIQQ------
25909_Tthe -------------------------------GLPPEWEER--FKVQGINTEEVK------
PAK1_Spur -------------------------------GMPEKWAQL--LSSSSISKTEQK------
CC1G_15304_Ccin -------------------------------GLPPTWSAA--LSQAGFSDEEIIAIHNRR
CC1G_00840_Ccin -------------------------------GLPKEWQQL--LQESGISRHEQE------
CC1G_02087_Ccin -------------------------------GLPEQWSKL--LTKSAITREDYA------
AqueK235_Aque -------------------------------GMPEAWAKL--LDSSGISQAEKA------
GK081_Glam -------------------------------GLPEEWQKLGLIPESMISTITDM------
PAK3_Hsap ------KNPQAVLDVLKF--------------------------------------YDSK
PAK2_Hsap ------KNPQAVLDVLKF--------------------------------------YDSN
PAK1_Hsap ------KNPQAVLDVLEF--------------------------------------YNSK
PAK3_Mmus ------KNPQAVLDVLKF--------------------------------------YDSK
PAK2_Mmus ------KNPQAVLDVLKF--------------------------------------YDSN
PAK1_Mmus ------KNPQAVLDVLEF--------------------------------------YNSK
pak-1_Cele ------QNPQAVLDALKY--------------------------------------YTQG
STE20_Scer ------QNMQAVMDIVKF--------------------------------------YQDV
SKM1_Scer ------RNSKAVIKALQF--------------------------------------YEDY
CLA4_Scer ------NNSAAVIQVLQF--------------------------------------YQEY
Pak3_Dmel ------KNPDAAYHAVKY--------------------------------------YNYS
Pak_Dmel ------KNPQAVLDVLKW--------------------------------------FDNT
Y38F1A.10_Cele ------KHQQPTLNVLSP--------------------------------------WGAY
PakA_Ddis ------QHPEEVLDVVKF--------------------------------------HAQY
PakB_Ddis ------EHSEVVIDVLDF--------------------------------------HMQQ
PakC_Ddis ------DKPSEWLSVLEF--------------------------------------QAGR
PakD_Ddis ------QHQEDVLDVLEF--------------------------------------HHVY
19075_Tthe ------PSFQDYKDLVEY--------------------------------------IIQN
25909_Tthe ------ENPQNMISIINN--------------------------------------YDQG
PAK1_Spur ------NNPQAVLDALKF--------------------------------------YDDS
CC1G_15304_Ccin AAGSRSPNSQYVLNARPPSPRIPHPYQQSASNVPIIAQPGPRTTSLPRQVSDASLRSTST
CC1G_00840_Ccin ------KNPQAVMEIVKF--------------------------------------YQEG
CC1G_02087_Ccin ------KDPQAVLDVLEF--------------------------------------YTDR
AqueK235_Aque ------KNPDAVVKALEF--------------------------------------MTKR
GK081_Glam ------ANAAPSLEDGGN--------------------------------------GDKP
PAK3_Hsap ETV--NNQKY-------------------------------------------MSFT---
PAK2_Hsap TVK----QKY-------------------------------------------LSFT---
PAK1_Hsap KTS--NSQKY-------------------------------------------MSFT---
PAK3_Mmus ETV--NNQKY-------------------------------------------MSFT---
PAK2_Mmus TVK----QKY-------------------------------------------LSFT---
PAK1_Mmus KTS--NSQKY-------------------------------------------MSFT---
pak-1_Cele ESSG---QKW-------------------------------------------LQYD---
STE20_Scer TETNG-EDKMF------------------------------------------KTFN---
SKM1_Scer NGLDT--MQFN-------------------------------------------DHL---
CLA4_Scer NGAGN--PT-N-------------------------------------------TLD---
Pak3_Dmel IKKKE-NEVF-------------------------------------------KPFI---
Pak_Dmel TKQR-PSSKY-------------------------------------------MTNA---
Y38F1A.10_Cele FNHIG-NE-L-------------------------------------------LKEN---
PakA_Ddis QGLASA------------------------------------------------------
PakB_Ddis QQQQAQQEQ--------------------------------------------QALM---
PakC_Ddis TMEKSNSQN---------------------------------------------------
PakD_Ddis NEKQQNSIKL-------------------------------------------LTNN---
19075_Tthe -DQ---------------------------------------------------------
25909_Tthe IEA---------------------------------------------------------
PAK1_Spur TAGNE---KF-------------------------------------------MTQH---
CC1G_15304_Ccin --RQRHPIPFGSPASASTASLHSSNAGSISNIKAVRQGASQDHSSRNHTPQLSISYSSDS
CC1G_00840_Ccin HGDVW-D-KLG-------------------------------------------NVG---
CC1G_02087_Ccin QKQEL--EDL--------------------------------------------SIG---
AqueK235_Aque SSHSDNDPKF-------------------------------------------LTAQ---
GK081_Glam L----I--KL-------------------------------------------SSQS---
PAK3_Hsap ------------------SG-------------------------DK-------------
PAK2_Hsap ------------------PP-------------------------EK-------------
PAK1_Hsap ------------------DK----------------------------------------
PAK3_Mmus ------------------SG-------------------------DK-------------
PAK2_Mmus ------------------PP-------------------------EK-------------
PAK1_Mmus ------------------DK----------------------------------------
pak-1_Cele ------------------MM-------------------------FIDDAPSRTPSYGLK
STE20_Scer ------------------TT-------------------------TG-------------
SKM1_Scer ------------------NT-------------------------SLDLK----------
CLA4_Scer ------------------KP-------------------------QSGET----------
Pak3_Dmel ------------------TEDVIHEESKEIENYVNYKNKHKSQDPEKS------------
Pak_Dmel ------------------IT-------------------------TH-------------
Y38F1A.10_Cele -----------------------------------------S--NDK-------------
PakA_Ddis ------------------------------------------------------------
PakB_Ddis ------------------QK----------------------------------------
PakC_Ddis ------------------------------------------------------------
PakD_Ddis ------------------SN----------------------------------------
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur ------------------KV----------------------------------------
CC1G_15304_Ccin NHSGVSGEDVYQQSRNGNFP-------------------------KDVSTPPGKPAHAAN
CC1G_00840_Ccin ------------------AP-------------------------TP-------------
CC1G_02087_Ccin ------------------AP-------------------------PRFNAGTGLGGLGKQ
AqueK235_Aque ------------------RY----------------------------------------
GK081_Glam ------------------ID-------------------------K--------------
PAK3_Hsap -----------------------------------------------------SAH-G--
PAK2_Hsap -------------------------------------------------------D-G--
PAK1_Hsap -----------------------------------------------------SAE-D--
PAK3_Mmus -----------------------------------------------------SAH-G--
PAK2_Mmus -------------------------------------------------------D-G--
PAK1_Mmus -----------------------------------------------------SAE-D--
pak-1_Cele PQPYSTSSLPYHGNKIQDPR------KMNPMTTST------------------SSA-G--
STE20_Scer -----------------------------------------------------LPGSPQ-
SKM1_Scer ---------------P-LKS------PTRYIINKR-TNSIK-R----------SVS----
CLA4_Scer -------------SSSQKSL------PNSYNDNKLRNNSVNSK----------SSS-G--
Pak3_Dmel -----------------------------------------------------DDD-G--
Pak_Dmel -----------------------------------------------------SGS-SLS
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis ------------------------------------------------------------
PakB_Ddis -----------------------------------------------------QM-----
PakC_Ddis ------------------------------------------------------------
PakD_Ddis -----------------------------------------------------NNN-N--
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur -----------------------------------------------------ILG-N--
CC1G_15304_Ccin PS------------IAQSFMSQASSLLNGHSHNRNESNASSTSKRLFGSQPSLWSS-P--
CC1G_00840_Ccin -------------------------------------------------------E-P--
CC1G_02087_Ccin PGPAEIRPLPKRNETSPPGL------TGTDSDN--L-SSAAAR----------AAE-H--
AqueK235_Aque ---------------------------------------------------------G--
GK081_Glam ------------------------------------------------------QI-D--
PAK3_Hsap -YI--------------AAH---------P------SS-TK-------------------
PAK2_Hsap -FP--------------SGT---------P------AL-NA-------------------
PAK1_Hsap -YN--------------SSN---------A------LN-VK-------------------
PAK3_Mmus -YI--------------AAH---------Q------SN-TK-------------------
PAK2_Mmus -FP--------------SGT---------P------AL-NT-------------------
PAK1_Mmus -YN--------------SSN---------T------LN-VK-------------------
pak-1_Cele -YN--------------SKQ--GVPPTTFS------VN-EN-------------------
STE20_Scer -VS--------------TPP---------A------NS-FN-------------------
SKM1_Scer ------------------RT---------L------RKGKT-------------------
CLA4_Scer -VS--------------SSM---------V------SQ-RK-------------------
Pak3_Dmel -SSTATETESSSGCGSSAGNSNS------S------SI-ND-------------------
Pak_Dmel RVS--------------SSS---------P------SS-TPTDSELHGSNSGGNLIGVQL
Y38F1A.10_Cele ----------SV--GDKNGN---------T------TT-NK-------------------
PakA_Ddis ------------------------------------------------------------
PakB_Ddis -QQ--------------SGI---------P------AH-ML-------------------
PakC_Ddis ------------------------------------------------------------
PakD_Ddis -NNNSNN------------------NLQQ-------------------------------
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur -KQ--------------SFE---------D------SF-EQ-------------------
CC1G_15304_Ccin -SS--------------SST---------ASRPQTAANTST-------------------
CC1G_00840_Ccin -YA--------------LAP---------E------NF-TN-------------------
CC1G_02087_Ccin -VN--------------GSH---------V------AN-AI-------------------
AqueK235_Aque -PT--------------PSR---------P------H--LS-------------------
GK081_Glam -FH--------------TGN---------I------AP-SF-------------------
PAK3_Hsap ------------------------------------------------------------
PAK2_Hsap ------------------------------------------------------------
PAK1_Hsap ------------------------------------------------------------
PAK3_Mmus ------------------------------------------------------------
PAK2_Mmus ------------------------------------------------------------
PAK1_Mmus ------------------------------------------------------------
pak-1_Cele ------------------------------------------------------------
STE20_Scer ------------------------------------------------------------
SKM1_Scer ------------------------------------------------------------
CLA4_Scer ------------------------------------------------------------
Pak3_Dmel ------------------------------------------------------------
Pak_Dmel GSMTLGPNANNVAVAGQILGNHYQQQQQHLLQQQQPLLHQNHNQHHMGISQSHSYNFVGH
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis ------------------------------------------------------------
PakB_Ddis ------------------------------------------------------------
PakC_Ddis ------------------------------------------------------------
PakD_Ddis ------------------------------------------------------------
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur ------------------------------------------------------------
CC1G_15304_Ccin ------------------------------------------------------------
CC1G_00840_Ccin ------------------------------------------------------------
CC1G_02087_Ccin ------------------------------------------------------------
AqueK235_Aque ------------------------------------------------------------
GK081_Glam ------------------------------------------------------------
PAK3_Hsap T-----------------------------------------------------------
PAK2_Hsap K-----------------------------------------------------------
PAK1_Hsap A-----------------------------------------------------------
PAK3_Mmus T-----------------------------------------------------------
PAK2_Mmus K-----------------------------------------------------------
PAK1_Mmus T-----------------------------------------------------------
pak-1_Cele R-----------------------------------------------------------
STE20_Scer -------------------------------KFPPSTSDSHNYGSRTGTPMSNHVMSPTL
SKM1_Scer D-----------------------------------------------------------
CLA4_Scer T-----------------------------------------------------------
Pak3_Dmel SSQQSTVPLDALEEVFKELKTNLEHRETLKAA----------------------------
Pak_Dmel T-----------------------------------------------------------
Y38F1A.10_Cele T-----------------------------------------------------------
PakA_Ddis ------------------------------------------------------------
PakB_Ddis N-----------------------------------------------------------
PakC_Ddis ------------------------------------------------------------
PakD_Ddis --------------------------QQQQN-----------------------------
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur Q-----------------------------------------------------------
CC1G_15304_Ccin S-----------------------------------------------------------
CC1G_00840_Ccin P------------------------------RSPPPPP--KKQPSQASSVHTQHTQSTPT
CC1G_02087_Ccin S-----------------------------------------------------------
AqueK235_Aque Q-----------------------------------------------------------
GK081_Glam L-----------------------------------------------------------
PAK3_Hsap ----AS---------------------------EPP--L---------------------
PAK2_Hsap ----GT---------------------------EAP--A---------------------
PAK1_Hsap ----VS---------------------------ETP--A---------------------
PAK3_Mmus ----AS---------------------------EPP--L---------------------
PAK2_Mmus ----GS---------------------------ETS--A---------------------
PAK1_Mmus ----VS---------------------------ETP--A---------------------
pak-1_Cele ----SS---------------------------MPPSYA---------------------
STE20_Scer NTDSSS-------------------ANGKFIPSRPA--P---------------------
SKM1_Scer ----S-ILP-----VYQ-------------SELKPF--P---------------------
CLA4_Scer ----S-QPPNTKSPVSL---GS--------GSLPPI--NTKLPTSQSNIPRHLQNVPNQQ
Pak3_Dmel ----PQ---------------------------EPP--P---------------------
Pak_Dmel ----VS---------------------------SST--S---------------------
Y38F1A.10_Cele ----TV---------------------------EPP--P---------------------
PakA_Ddis ------------------------------------------------------------
PakB_Ddis ----NP---------------------------KPP--T---------------------
PakC_Ddis ------------------------------------------------------------
PakD_Ddis ------------------------------------------------------------
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur ----AS---------------------------ITP--K---------------------
CC1G_15304_Ccin ----SN---------------------------HSN--A---------------------
CC1G_00840_Ccin SVGP--------------------------TSYRPA--P---------------------
CC1G_02087_Ccin ----SVQGPRGPLPVPTLPQATRAAPPRPIAASRPP--P---------------------
AqueK235_Aque ----DT---------------------------FTP--L---------------------
GK081_Glam ----AT---------------------------NAT--L---------------------
PAK3_Hsap --------------------AP-------PVSEEED------------------------
PAK2_Hsap --------------------V---------VTEEE-------------------------
PAK1_Hsap --------------------VP-------PVSEDED------------------------
PAK3_Mmus --------------------AP-------PVSEEED------------------------
PAK2_Mmus --------------------V---------VTEED-------------------------
PAK1_Mmus --------------------VP-------PVSEDED------------------------
pak-1_Cele --------------------PP-------PVPHGE-------------------------
STE20_Scer --------------------KP-------PSSASASAPIIKSPVMNSAANVSPLKQTHAP
SKM1_Scer --------------------RP-------SDDDY--------------------------
CLA4_Scer YPKMRNGHSPTNGQFPRGPMHPNNSQRSLQQQQQ--------------------------
Pak3_Dmel --------------------VP-------PK---K-------------------------
Pak_Dmel --------------------Q--------HSSANED------------------------
Y38F1A.10_Cele -----------------------------PE---E-------------------------
PakA_Ddis ------------------------------------------------------------
PakB_Ddis --------------------IP-------IRDANKQ------------------------
PakC_Ddis ------------------------------------------------------------
PakD_Ddis ------------------------------------------------------------
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur --------------------PP-------SRPGQED------------------------
CC1G_15304_Ccin -----------------------------AVTQPTD------------------------
CC1G_00840_Ccin --------------------TP-------PTAATPALDR--------------STSQRTP
CC1G_02087_Ccin --------------------QP-------PKDVT--------------------------
AqueK235_Aque --------------------QP-------IRPAPQP------------------------
GK081_Glam --------------------DS-------LYHIDQM------------------------
PAK3_Hsap -------------EEE-EEEED--------------EN-EPPPVIAPRPEHT--------
PAK2_Hsap -------------------DDD--------------EE-TAPPVIAPRPDHT--------
PAK1_Hsap -------------D-----DDD--------------DA-TPPPVIAPRPEHT--------
PAK3_Mmus -------------EEE-EEEED--------------DN-EPPPVIAPRPEHT--------
PAK2_Mmus -------------------DDD--------------ED-AAPPVIAPRPDHT--------
PAK1_Mmus -------------------DDD--------------DA-TPPPVIAPRPEHT--------
pak-1_Cele -------------------TP---------------AD-IVPPAIPDRPART--------
STE20_Scer TTPNRTSPNRSSISRN-ATLKK--------------EE-QPLPPIPPTKSKT--------
SKM1_Scer -------------KFT-NIEDNK--------------VREEGRVHV-SK-----------
CLA4_Scer -------------QQQ-QQKQQHQQYPYHHQGPSPSPSPSPSPLNPYRPHHN--------
Pak3_Dmel -------------------SPH--------------TI-PPKPQIKPKPRVT--------
Pak_Dmel -------------DMLGPQHPQ--------------QQ-PPPPPVASRPERT--------
Y38F1A.10_Cele ----------------------------------------P-P-----------------
PakA_Ddis ----------------------------------------PAM-----------------
PakB_Ddis -------------------PHN--------------QL-QPTPHQPPQHHHQ--------
PakC_Ddis ------------------------------------------------------------
PakD_Ddis ------------------------------------QQ-LKQKLNITNNQQ---------
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur -------------D----VSED--------------ED-AEAPAIAPRPAHS--------
CC1G_15304_Ccin ------------------------------------NN-ASPEASPPQPKRT--------
CC1G_00840_Ccin AKPARPA----DIGRS-NTTRD--------------RR-SPAPP---ANNGLAAGSKSYS
CC1G_02087_Ccin -------------PST-DDLRNR--------------VKPQG--PVPLPVRN--------
AqueK235_Aque ---------------------P--------------GS-ETAPAIPPRPAIT--------
GK081_Glam -------------------DIL--------------TD-AVKPTL-PSKKLL--------
PAK3_Hsap --KS-IYT-----R----------------------------------------------
PAK2_Hsap --KS-IYT-----R----------------------------------------------
PAK1_Hsap --KS-VYT-----R----------------------------------------------
PAK3_Mmus --KS-IYT-----R----------------------------------------------
PAK2_Mmus --KS-IYT-----R----------------------------------------------
PAK1_Mmus --KS-VYT-----R----------------------------------------------
pak-1_Cele --LS-IYT-----K----------------------------------------------
STE20_Scer --SP-IISTAH-TP----------------------------------------------
SKM1_Scer ------------------------------------------------------------
CLA4_Scer --MINPYS-----K----------------------------------------------
Pak3_Dmel --QK-FSR-----T----------------------------------------------
Pak_Dmel --KS-IYT-----R----------------------------------------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis ------------------------------------------------------------
PakB_Ddis --QQ--------------------------------------------------------
PakC_Ddis ------------------------------------------------------------
PakD_Ddis ------------------------------------------------------------
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur --QS-RYY-----S----------------------------------------------
CC1G_15304_Ccin --NA-LPP-----RLSLHQASGSGDLSAWAGMLLSGLSSDLDDKLTLGPSPLGPTPLTPQ
CC1G_00840_Ccin KPSP-GSSQTDLPL----------------------------------------------
CC1G_02087_Ccin --D-SLPT----------------------------------------------------
AqueK235_Aque --KN-K------------------------------------------------------
GK081_Glam --RS-LQT-----Q----------------------------------------------
PAK3_Hsap ------------------------------------------------------------
PAK2_Hsap ------------------------------------------------------------
PAK1_Hsap ------------------------------------------------------------
PAK3_Mmus ------------------------------------------------------------
PAK2_Mmus ------------------------------------------------------------
PAK1_Mmus ------------------------------------------------------------
pak-1_Cele ------------------------------------------------------------
STE20_Scer ------------------------------------------------------------
SKM1_Scer ------------------------------------------------------------
CLA4_Scer ------------------------------------------------------------
Pak3_Dmel ------------------------------------------------------------
Pak_Dmel ------------------------------------------------------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis ------------------------------------------------------------
PakB_Ddis ------------------------------------------------------------
PakC_Ddis ------------------------------------------------------------
PakD_Ddis ------------------------------------------------------------
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur ------------------------------------------------------------
CC1G_15304_Ccin SAPASAATQGPSSFTVSNRPTHTSHSRSLGGESSKARPEPLSELEEPIDNDAQYANLSPP
CC1G_00840_Ccin ------------------------------------------------------------
CC1G_02087_Ccin ------------------------------------------------------------
AqueK235_Aque ------------------------------------------------------------
GK081_Glam ------------------------------------------------------------
PAK3_Hsap ------------------------------------------------------------
PAK2_Hsap ------------------------------------------------------------
PAK1_Hsap ------------------------------------------------------------
PAK3_Mmus ------------------------------------------------------------
PAK2_Mmus ------------------------------------------------------------
PAK1_Mmus ------------------------------------------------------------
pak-1_Cele ------------------------------------------------------------
STE20_Scer ------------------------------------------------------------
SKM1_Scer ------------------------------------------------------------
CLA4_Scer ------------------------------------------------------------
Pak3_Dmel ------------------------------------------------------------
Pak_Dmel ------------------------------------------------------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis ------------------------------------------------------------
PakB_Ddis ------------------------------------------------------------
PakC_Ddis ------------------------------------------------------------
PakD_Ddis ------------------------------------------------------------
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur ------------------------------------------------------------
CC1G_15304_Ccin WTGDAGSSSPLWSEIEGILSQGRSPTASEDRHEPGPYSAALAETFSPTLPFSPEEDRMAQ
CC1G_00840_Ccin ------------------------------------------------------------
CC1G_02087_Ccin ------------------------------------------------------------
AqueK235_Aque ------------------------------------------------------------
GK081_Glam ------------------------------------------------------------
PAK3_Hsap ----------------------------------SVVE----------------------
PAK2_Hsap ----------------------------------SVID----------------------
PAK1_Hsap ----------------------------------SVIE----------------------
PAK3_Mmus ----------------------------------SVVE----------------------
PAK2_Mmus ----------------------------------SVID----------------------
PAK1_Mmus ----------------------------------SVIE----------------------
pak-1_Cele ----------------------------------PKEE----------------------
STE20_Scer ----------------------------------QQVA----------------------
SKM1_Scer ----------------------------------------------ESTADSQTKQLGKK
CLA4_Scer ----------------------------------QPQSP-------LSSQSTQNQAIPRY
Pak3_Dmel ----------------------------------SDIR----------------------
Pak_Dmel ----------------------------------PIED----------------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis ------------------------------------------------------------
PakB_Ddis ------------------------------------------------------------
PakC_Ddis ------------------------------------------------------------
PakD_Ddis ---------------------------------N--------------------------
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur ----------------------------------RIEQ----------------------
CC1G_15304_Ccin ERRLRNEASRERLEREEDLNRLSVNTARPNRDSSRSIP----------------------
CC1G_00840_Ccin ----------------------------------KQSA----------------------
CC1G_02087_Ccin -------------------------------------APGIHQSASQRSQQEQRERQQQQ
AqueK235_Aque -------------------------------------D----------------------
GK081_Glam ----------------------------------NIFI----------------------
PAK3_Hsap -------------------------------------S---------------IA-----
PAK2_Hsap -------------------------------------P---------------VP-----
PAK1_Hsap -------------------------------------P---------------LP-----
PAK3_Mmus -------------------------------------S---------------IA-----
PAK2_Mmus -------------------------------------P---------------IP-----
PAK1_Mmus -------------------------------------P---------------LP-----
pak-1_Cele -------------------------------------E---------------EK-----
STE20_Scer -------------------------------------Q----------------------
SKM1_Scer EQK----------------------VIQSHLRRHDNNS---------------TF--RPH
CLA4_Scer AQN----------------------SSPTAAHFQPQRT---------------AP--KPP
Pak3_Dmel -------------------------------------RDEDSDNQHKINTDTIII-----
Pak_Dmel -------------------------------------L---------------QP-----
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis ------------------------------------------------------------
PakB_Ddis ------------------------------------------------------------
PakC_Ddis ------------------------------------------------------------
PakD_Ddis ---------------------------------------------NTIININ---IT---
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur -------------------------------------T---------------PP-----
CC1G_15304_Ccin -------------------------------------P---------------TPIVPPP
CC1G_00840_Ccin -------------------------------------P---------------G------
CC1G_02087_Ccin EQRRLEQREREREQREREREREREREEREAYRAQQERP---------------PL--APS
AqueK235_Aque -------------------------------------L---------------PP-----
GK081_Glam -------------------------------------S---------------RP-----
PAK3_Hsap ---------------------------S-----------PAVPNKE--------------
PAK2_Hsap ---------------------------A-----------PV-------------------
PAK1_Hsap ----------------------------------------VTPTRDVA------------
PAK3_Mmus ---------------------------S-----------PAAPNKE--------------
PAK2_Mmus ---------------------------A-----------PV-------------------
PAK1_Mmus ----------------------------------------VTPTRDVA------------
pak-1_Cele ---------------------------I-----------P--------------------
STE20_Scer ---------------------------S-----------PKAPAQET-------------
SKM1_Scer RLAPS------------------------------------A------------------
CLA4_Scer ISAPRAPYPSNQNATSN----THV---Q-----------PVAPKNDQ-------------
Pak3_Dmel ---------------------------K-----------PAVGAQD--------------
Pak_Dmel -----------------------AIIPM-----------PVAP----A------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis ------------------------------------------------------------
PakB_Ddis ---------------------------P-----------PQQHHHQ--------------
PakC_Ddis ------------------------------------------------------------
PakD_Ddis ---------------------------S-----------PSISVNNN-------------
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur ---------------------------E-----------PSPPSPA--------------
CC1G_15304_Ccin RQLPN----------------------R-----------PA-PIDA-G------------
CC1G_00840_Ccin ---------------------------P-----------PAHPPRDR-------------
CC1G_02087_Ccin KSAPGTAQPATQPATGPAGALEGPPPVL-----------PLQPKKVQ-------------
AqueK235_Aque ---------------------------T-----------PP-PKSA--------------
GK081_Glam ---------------------------TGFTHKNHVTVDPTNATRY-IGLPKEWEAKLEA
PAK3_Hsap ----------------------------VT-------P--------PSA-----------
PAK2_Hsap ------------------------------------------------G-----------
PAK1_Hsap ----------------------------TS-------PI------SPTE-----------
PAK3_Mmus ----------------------------DI-------P--------PSA-----------
PAK2_Mmus ------------------------------------------------G-----------
PAK1_Mmus ----------------------------TS-------PI------SPTE-----------
pak-1_Cele -----------------------------------------------DL-----------
STE20_Scer -------------------------------------------VTTPTS-----------
SKM1_Scer ----------------------------------------------PAT-----------
CLA4_Scer ----------------------------STPQTMRQAPK------RPDA-----------
Pak3_Dmel ----------------------------------------------AGA-----------
Pak_Dmel ----------------------------TT-------PA------TPLQNHRTPGGISAP
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis ------------------------------------------------------------
PakB_Ddis ----------------------------QQ-------QQ------QHNN-----------
PakC_Ddis ------------------------------------------------------------
PakD_Ddis ----------------------------TYNNNNNN---NNNNEINPS------------
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur ----------------------------PA-------PA------HPSN-----------
CC1G_15304_Ccin ----------------------------HS-------PS------PPNS-----------
CC1G_00840_Ccin ----------------------------AD-------PRAQNHAPSPAA-----------
CC1G_02087_Ccin ----------------------------I--Q-AADKPA------KPAG-----------
AqueK235_Aque ----------------------------LK-------P--------PAH-----------
GK081_Glam VGLDIQKIGQNKDDLDALCAIMDNFYDDKI-------PI------KPDD-----------
PAK3_Hsap ------EN---------------------------------------------A--NSST
PAK2_Hsap -------D---------------------------------------------S--HVDG
PAK1_Hsap ------NN--T------------------------------------------T--PPDA
PAK3_Mmus ------EN---------------------------------------------A--NSTT
PAK2_Mmus -------D---------------------------------------------S--NVDS
PAK1_Mmus ------NN--T------------------------------------------T--PPDA
pak-1_Cele --------------------------------------------------------SKGQ
STE20_Scer ------K---P------------------------------------------A--QARS
SKM1_Scer ------KN---------------------------------------------H--DSKT
CLA4_Scer ------DV---------------------------------------------A--QPGG
Pak3_Dmel -------D---------------------------------------------D--NPDE
Pak_Dmel AASPMMHNNATTTLDKNKNNANLYTPEPTVAQVSAGGPSSQVAGNQIAVPQAAV--APAA
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis ------------------------------------------------------------
PakB_Ddis ------NN--N------------------------------------------N--NNNN
PakC_Ddis ------------------------------------------------------------
PakD_Ddis ------------------------------------------------------------
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur -------A---------------------------------------------T--NATT
CC1G_15304_Ccin ------SF---------------------------------------------D--SEES
CC1G_00840_Ccin ------SN--L------------------------------------------A--KVAG
CC1G_02087_Ccin ------GV---------------------------------------------A---AAA
AqueK235_Aque ---------------------------------------------------------AGA
GK081_Glam ------QD--F------------------------------------------MIQAFDG
PAK3_Hsap -----------------L-YRN--------------------------------------
PAK2_Hsap -----------------A-AKS--------------------------------------
PAK1_Hsap -----------------L-TRN--------------------------------------
PAK3_Mmus -----------------L-YRN--------------------------------------
PAK2_Mmus -----------------G-AKS--------------------------------------
PAK1_Mmus -----------------L-TRN--------------------------------------
pak-1_Cele -----------------F-GVQ--------------------------------------
STE20_Scer -----------------L-SKE--------------------------------------
SKM1_Scer -----------------K-WHK--------------------------------------
CLA4_Scer --------------------VA--------------------------------------
Pak3_Dmel -------------------TIL--------------------------------------
Pak_Dmel -----------------T-PNT--------------------------------------
Y38F1A.10_Cele ---------------------V--------------------------------------
PakA_Ddis ------------------------------------------------------------
PakB_Ddis NNNNNNQQSAQQQSAGIL-SQQ--------------------------------------
PakC_Ddis ------------------------------------------------------------
PakD_Ddis -------------------SPN--------------------------------------
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur -----------------Q-AQQ--------------------------------------
CC1G_15304_Ccin -----------------S-ASSSQSQDRYPTPTTANSTSSPLRYYLEPSPSPSQASFSPV
CC1G_00840_Ccin -----------------V-ATP--------------------------------------
CC1G_02087_Ccin -----------------A-ALE--------------------------------------
AqueK235_Aque -----------------Q-QGG--------------------------------------
GK081_Glam -----------------TDKYA--------------------------------------
PAK3_Hsap ------------------------------------------------------------
PAK2_Hsap ------------------------------------------------------------
PAK1_Hsap ------------------------------------------------------------
PAK3_Mmus ------------------------------------------------------------
PAK2_Mmus ------------------------------------------------------------
PAK1_Mmus ------------------------------------------------------------
pak-1_Cele ------------------------------------------------------------
STE20_Scer ------------------------------------------------------------
SKM1_Scer ------------------------------------------------------------
CLA4_Scer ------------------------------------------------------------
Pak3_Dmel ------------------------------------------------------------
Pak_Dmel ------------------------------------------------------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis ------------------------------------------------------------
PakB_Ddis ------------------------------------------------------------
PakC_Ddis ------------------------------------------------------------
PakD_Ddis ------------------------------------------------------------
19075_Tthe ------------------------------------------------------------
25909_Tthe ------------------------------------------------------------
PAK1_Spur ------------------------------------------------------------
CC1G_15304_Ccin VARHKEYPNVPPAYDIDEDLDEDDEEGTNLIIPHQIITAPSPQANRPTIVIENVSPGGAL
CC1G_00840_Ccin ------------------------------------------------------------
CC1G_02087_Ccin ------------------------------------------------------------
AqueK235_Aque ------------------------------------------------------------
GK081_Glam ------------------------------------------------------------
PAK3_Hsap -------T---------------DRQ-RKKSKMTDEEILEKLR--------SIVSV-GDP
PAK2_Hsap -------L---------------DKQ-KKKTKMTDEEIMEKLR--------TIVSI-GDP
PAK1_Hsap -------T---------------EKQ-KKKPKMSDEEILEKLR--------SIVSV-GDP
PAK3_Mmus -------T---------------DRQ-RKKSKMTDEEILEKLR--------SIVSV-GDP
PAK2_Mmus -------S---------------DKQ-KKKAKMTDEEIMEKLR--------TIVSI-GDP
PAK1_Mmus -------T---------------EKQ-KKKPKMSDEEILEKLR--------SIVSV-GDP
pak-1_Cele -------A---------------RGQ-KAKKKMTDAEVLTKLR--------TIVSI-GNP
STE20_Scer -------L--------------NEKK-REERERRKKQLYAKLN--------EICSD-GDP
SKM1_Scer ----------------------EDLL-ELKNNDDSNEIIMKMK--------TVAID-VNP
CLA4_Scer ----------------------KPKK-PARPTMSTAEIMSKLK--------KVTVN-ADP
Pak3_Dmel ----------------------RRSK-EKRAQKTDAEIYVELR--------AICNS-DDP
Pak_Dmel -------R---------------AAN-AKKKKMSDEEILEKLR--------TIVSV-GDP
Y38F1A.10_Cele ----------------------RVRA-SHREKLSDSEVLNQLR--------EIVNP-SNP
PakA_Ddis --------------------------HAPSIPLT-DEPPVTLN--------DLISL-DDP
PakB_Ddis -------QEQQLEEMMCGGAYDDEQYDLNNQPLP-DETNVSLY--------DLVSQ-EDP
PakC_Ddis -----------------------------LSALP-DESNLTLS--------DLVTK-EDP
PakD_Ddis ----------------------NNNN-YYDSLLEIEEPSFTLK--------DLVSL-ENP
19075_Tthe -------------------------P-N-KERLSEYEFNKRAENI-------QIEE-NDP
25909_Tthe -------------------------P-KKIILPTNDEFLKIVENI-------GLQE-DDP
PAK1_Spur -------E--------------RREK-MKKKKMSDDEILEKLSKxMTLNGGSIVSV-GDP
CC1G_15304_Ccin STALPTGT--------------PASP-FQRYRGWLSEVVQPLE--------EYIDEGVDP
CC1G_00840_Ccin ----------------------RRRE-KKVDKAKDEDIIKRLQ--------QICTD-ADP
CC1G_02087_Ccin ----------------------KPKE-KRISTMTEVQIMEKLR--------QVVSD-EDP
AqueK235_Aque -------A---------------QKR-DKKPKMSDAEVLAHLR--------QIVSI-GDP
GK081_Glam -------V--------------PKFH-SLPTADTYNDILEKLH--------DNFTEVNTI
:
PAK3_Hsap KKKYTR-FEKIGQGASGTVYTALDIA---------------------T-GQ--EVAIKQM
PAK2_Hsap KKKYTR-YEKIGQGASGTVFTATDVA---------------------L-GQ--EVAIKQI
PAK1_Hsap KKKYTR-FEKIGQGASGTVYTAMDVA---------------------T-GQ--EVAIKQM
PAK3_Mmus KKKYTR-FEKIGQGASGTVYTALDIA---------------------T-GQ--EVAIKQM
PAK2_Mmus KKKYTR-YEKIGQGASGTVFTATDVA---------------------L-GQ--EVAIKQI
PAK1_Mmus KKKYTR-FEKIGQGASGTVYTAMDVA---------------------T-GQ--EVAIKQM
pak-1_Cele DRKYRK-VDKIGSGASGSVYTAIEIS---------------------T-EA--EVAIKQM
STE20_Scer STKYAN-LVKIGQGASGGVYTAYEIG---------------------T-NV--SVAIKQM
SKM1_Scer RPYFQL-VEKAGQGASGAVYLSKRIKLPQENDP--RFLK--SHCHRVV-GE--RVAIKQI
CLA4_Scer SQCFKV-IEKAGQGASGSVYLAERTHIPTESNM--IELINNDIDEPHV-GD--KVAIKQM
Pak3_Dmel RERYKT-TQEVGKGASGIVFIAADLQ---------------------N-ES--QVAVKTI
Pak_Dmel NRKYTK-MEKIGQGASGTVYTAIESS---------------------T-GM--EVAIKQM
Y38F1A.10_Cele LGKYEM-KKQIGVGASGTVFVANVAG---------------------S-TD--VVAVKRM
PakA_Ddis KKIYYN-INKIGEGGAGEVFEAINSR---------------------T-NQ--TIAIKKM
PakB_Ddis TKLFGEGSTKIGEGAAGEVFVVTQLK---------------------T-NN--KVAIKKM
PakC_Ddis TKIYKN-MTKIGEGAAGEVFVATSSK---------------------N-NK--RVAIKKI
PakD_Ddis IDLYKV-REVVGGGSTGKVYVGENSI---------------------T-GE--KVAIKKM
19075_Tthe SNHYDF-LSQIGKGATCKVYRCKNKQ---------------------T-GQ--ECAMRVI
25909_Tthe SKFYNF-GDKLGKGAMCQVFKATKRK---------------------TKNE--EFAVRVM
PAK1_Spur KRKYSK-FEKIGQGASGVVYTAIEVA---------------------T-GQ--EVAIKQM
CC1G_15304_Ccin RDHYLD-LKEIAEGESGSVFSARLIQKDADKLRLPAHVKAQDADDFAN-NREVLVAIKSV
CC1G_00840_Ccin TKLYRN-LVKIGQGASGGVYTAYQVG---------------------T-NM--SVAIKQM
CC1G_02087_Ccin KLIYSK-IKKVGQGASGHVYVAKELA---------------------T-GK--KVAIKEM
AqueK235_Aque TKRYTK-MEKIGQGASGVVYTASEIA---------------------T-GN--EVAIKQM
GK081_Glam ADVYSN-PQEVGHGSSGHVYRATEIK---------------------T-GN--VVAIKSI
: . * *: *:: :
PAK3_Hsap NLQ----------------QQPKKELIINEILVMRENKN-PNIVNYLDSYLVG--DELWV
PAK2_Hsap NLQ----------------KQPKKELIINEILVMKELKN-PNIVNFLDSYLVG--DELFV
PAK1_Hsap NLQ----------------QQPKKELIINEILVMRENKN-PNIVNYLDSYLVG--DELWV
PAK3_Mmus NLQ----------------QQPKKELIINEILVMRENKN-PNIVNYLDSYLVG--DELWV
PAK2_Mmus NLQ----------------KQPKKELIINEILVMKELKN-PNIVNFLDSYLVG--DELFV
PAK1_Mmus NLQ----------------QQPKKELIINEILVMRENKN-PNIVNYLDSYLVG--DELWV
pak-1_Cele NLK----------------DQPKKELIINEILVMRENKH-ANIVNYLDSYLVC--DELWV
STE20_Scer NLE----------------KQPKKELIINEILVMKGSKH-PNIVNFIDSYVLK--GDLWV
SKM1_Scer RLS----------------EQPKKQLIMNELLVMNDSRQ-ENIVNFLEAYIID-DEELWV
CLA4_Scer VLS----------------KQPRKELIVNEILVMKDSRH-KNIVNFLEAYLRT-DDDLWV
Pak3_Dmel DMK----------------NQSSKDLILTEIRVLKDFNH-KNLVNFLDAYLLEPEDQLWV
Pak_Dmel NLS----------------QQPKKELIINEILVMRENKH-PNVVNYLDSYLVS--EELWV
Y38F1A.10_Cele AFK----------------TQPKKEMLLTEIKVMKQYRH-PNLVNYIESYLVD-ADDLWV
PakA_Ddis KLK----------------AQNL-KTVINEIGMMKNSNH-ENIVQYIDSYIVA-D-ELWV
PakB_Ddis PLN----------------QQNM-KLIVTEIGIMKSCRH-QNIIDYIDSYLVG-D-SLWV
PakC_Ddis EIN----------------NDNA-KLLVTEIAIMKTSHH-DNIVNYIDSYIVN-DRELWV
PakD_Ddis KVD----------------NNNIK-NIINEISTMKNSKH-KNVIKYVSSHLVI--NHIWL
19075_Tthe RML----------------NPDQIEKTKMEILLMNESKN-NNIVQYYKSYIYM--DVIFM
25909_Tthe KLG----------------DEGSMNKIKIEMAIMKICQH-KNIVRYYETFKFM--SCLFM
PAK1_Spur NLQ----------------QQPKKELIINEILVMRENKH-QNIVNYLDSYLVS--DELWV
CC1G_15304_Ccin AIV--------------PSGSPKLKDLQHELGLMKGLHH-ENVIGLDSLYVDFLEDTLWI
CC1G_00840_Ccin DLD----------------KQPKKDLIINEILVMRSSRH-PNIVNYIDSFLYK--NDLWV
CC1G_02087_Ccin DLS----------------HQPRKELIVNEILVMKESQH-PNIVNFLNSYLVK-NNELWV
AqueK235_Aque NLQ----------------QQPKKELIINEIIVMKEIKQ-PNIVNFLDSYLVG-ESELWV
GK081_Glam SAINFLTDDGKKVRDIKSAEAATLMALKNEVALMYLSKECEYIVKLHKVYFSKAAKEFYM
*: : .. :: . . :::
PAK3_Hsap VMEYLAGGSLTDVVTE---------------------TCMDEGQIAAVCRECLQALDFLH
PAK2_Hsap VMEYLAGGSLTDVVTE---------------------TCMDEAQIAAVCRECLQALEFLH
PAK1_Hsap VMEYLAGGSLTDVVTE---------------------TCMDEGQIAAVCRECLQALEFLH
PAK3_Mmus VMEYLAGGSLTDVVTE---------------------TCMDEGQIAAVCRECLQALDFLH
PAK2_Mmus VMEYLAGGSLTDVVTE---------------------TCMDEAQIAAVCRECLQALEFLH
PAK1_Mmus VMEYLAGGSLTDVVTE---------------------TCMDEGQIAAVCRECLQALEFLH
pak-1_Cele VMEYLAGGSLTDVVTE---------------------CQMEDGIIAAVCREVLQALEFLH
STE20_Scer IMEYMEGGSLTDVVTH---------------------CILTEGQIGAVCRETLSGLEFLH
SKM1_Scer IMEYMEGGCLTDILDAVARSNT-----------GEHSSPLNENQMAYIVKETCQGLKFLH
CLA4_Scer VMEFMEGGSLTDIIENSPTND-------------NSHSPLTEPQIAYIVRETCQGLKFLH
Pak3_Dmel VMEYMDGGPLTDVVTE---------------------TVMKERQIACVCRETLYAISFLH
Pak_Dmel VMEYLPGGSLTDVVTE---------------------TCMDEGQIAAVCREVLQALEFLH
Y38F1A.10_Cele VMDYLEGGNLTDVVVK---------------------TELDEGQIAAVLQECLKALHFLH
PakA_Ddis AMEFMSGGCLTEVLDQY------------------RDIQLNESQIAFVCQEVLRGLEYIH
PakB_Ddis AMEFMGGGCLTEILEQF------------------NSVKLVEAQIAYVCAETLKGLAYIH
PakC_Ddis AMEFMGGGCLTDILEAF------------------DNIKMSEIQIAYVVKETLKALQYIH
PakD_Ddis IMEYMSYGSLTDLISNCINIQCNGNNQQQQQQQQQQQTYFIESHIAYICQQVLQGMDYIH
19075_Tthe AIEYMNAGSLTELIYGN-------------------FSFLSEQMASYICEQILFGLFFIH
25909_Tthe VIEYMNGGSLTEIIYQN-------------------FKTIPEDIIAYILREIIQGLNFIH
PAK1_Spur VMEFLAGGSLTDVVTE---------------------TCMDEGQIASVCRECLQALQFLH
CC1G_15304_Ccin RMELME-RSLADIIGLVD-----------------AGLMLPDRMMARFASDILSGLDYLQ
CC1G_00840_Ccin VMEYMEGGSLTDVVTA---------------------NLMTEGQIAAVSRETCQGLEHLH
CC1G_02087_Ccin VMEYMEGGALTDVIEN---------------------NTLEEDQISSICLETCKGLQHLH
AqueK235_Aque VMEYLAGGSLTDVVTE---------------------TCMNEGQIAAVCRECLQALKFLH
GK081_Glam IMDYCNANCLTNILSRH-------------------GYIKNERVSCMIIRDILKALNHLH
:: *:::: : . : .: .::
PAK3_Hsap SNQVIHRDIKSDNILLGMD----------------GSVKLTDFGFCAQITPEQSKRSTMV
PAK2_Hsap ANQVIHRDIKSDNVLLGME----------------GSVKLTDFGFCAQITPEQSKRSTMV
PAK1_Hsap SNQVIHRDIKSDNILLGMD----------------GSVKLTDFGFCAQITPEQSKRSTMV
PAK3_Mmus SNQVIHRDIKSDNILLGMD----------------GSVKLTDFGFCAQITPEQSKRSTMV
PAK2_Mmus ANQVIHRDIKSDNVLLGME----------------GSVKLTDFGFCAQITPEQSKRSTMV
PAK1_Mmus SNQVIHRDIKSDNILLGMD----------------GSVKLTDFGFCAQITPEQSKRSTMV
pak-1_Cele SRHVIHRDIKSDNILLGMD----------------GSVKLTDFGFCAQLSPEQRKRTTMV
STE20_Scer SKGVLHRDIKSDNILLSME----------------GDIKLTDFGFCAQINELNLKRTTMV
SKM1_Scer NKKIIHRDIKSDNILLNSQ----------------GLVKITDFGFCVELTEKRSKRATMV
CLA4_Scer DKHIIHRDIKSDNVLLDTR----------------ARVKITDFGFCARLTDKRSKRATMV
Pak3_Dmel AKGIIHRDIKSDNVLLGMD----------------GSVKVTDFGFCANIEG-DEKRQTMV
Pak_Dmel ANQVIHRDIKSDNILLGLD----------------GSVKLTDFGFCAQISPEQSKRTTMV
Y38F1A.10_Cele RHSIVHRDIKSDNVLLGMN----------------GEVKLTDMGFCAQIQP-GSKRDTVV
PakA_Ddis KFNRIHRDIKSDNILIGAN----------------GEIKLADFGYAAQLTQIRQERNSVV
PakB_Ddis SQHRIHRDIKSDNILLGSD----------------GSVKLADFGYAAQLTKSKQKRVTIV
PakC_Ddis SLHRIHRDIKSDNILLGSE----------------GSVKIADFGYAAQLTQKQQKRNTVV
PakD_Ddis KGHRTHRDIKSDNILLGKD----------------GSVKIADFGFVANLTRKKLQRNSVV
19075_Tthe RTNQIHRDLKSDNILLNQN----------------GDVKIADFGFATQLTREHFSKKSQV
25909_Tthe LQNQAHRDLKSDNILVNKN----------------GEVKVADFGFATQLTQEKQRRKSVV
PAK1_Spur QRHVIHRDIKSDNILLGMD----------------GNVKLTDFGFCAQITPEQSKRTTMV
CC1G_15304_Ccin RHHIAHRDVRSDNLLINKH----------------GVLKLTDFANAVQVSAQNPMRTEPA
CC1G_00840_Ccin RHGVIHRDIKSDNVLLSMV----------------GDIKLTDFGFCAQISEGHAKRTTMV
CC1G_02087_Ccin SQSIIHRDIKSDNVLLDAQ----------------GRVKITDFGFCAKLTDQKSKRATMV
AqueK235_Aque DNHVIHRDIKSDNILLGMD----------------GQVKLTDFGFCAQITPEQSKRSTMV
GK081_Glam ENHRIYRDLKSDNVLLNAELINSLAQDGAITKKKKFSLKLSDFGFAVQLNTKQPTRKSVV
:**::***:*:. :*::*:. ..: : .
PAK3_Hsap GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQ
PAK2_Hsap GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQ
PAK1_Hsap GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQ
PAK3_Mmus GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQ
PAK2_Mmus GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQ
PAK1_Mmus GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQ
pak-1_Cele GTPYWMAPEVVTRKQYGPKVDVWSLGIMAIEMVEGEPPYLNENPLRAIYLIATNGKPDFP
STE20_Scer GTPYWMAPEVVSRKEYGPKVDIWSLGIMIIEMIEGEPPYLNETPLRALYLIATNGTPKLK
SKM1_Scer GTPYWMAPEIVNQKGYDEKVDVWSLGIMLIEMIEGEPPYLNEDPLKALYLIANNGSPKLR
CLA4_Scer GTPYWMAPEVVKQREYDEKIDVWSLGIMTIEMLEGEPPYLNEDPLKALYLIATNGTPKLK
Pak3_Dmel GTPYWMAPEVVTRKKYGKKVDIWSIGIMAIEMIEGQPPYLYETPLRALYLIAANGRPDIK
Pak_Dmel GTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIK
Y38F1A.10_Cele GTPYWMSPEILNKKQYNYKVDIWSLGIMALEMIDGEPPYLRETPLKAIYLIAQNGKPEIK
PakA_Ddis GTPYWMAPELIRGNNYDFKVDVWSLGIMTREMAEGEPPYLEFPPLRALFLLTTQGLPPIR
PakB_Ddis GTPYWMAPELIRGQNYDRKVDIWSLGIMAMEMAESEPPYMSFPPLRALFLITTKGIPDLK
PakC_Ddis GTPYWMAPELIRGHDYGVKVDIWSLGIMMMEMAEGEPPYMDFPPLRALFLITTKGIPPLK
PakD_Ddis GTPYFMAPELIRGNQYNHKVDIWSLGILARELSEGEPPYAKYPPVRALFLLTLEGVPDFK
19075_Tthe GTPAWMAPELILRKDYSQKVDIWSLGVICIEILEGEPPYIRDKPAKAMYYITKK-KPHKL
25909_Tthe GTPAWMAPELILKKEYNEKVDVWSTGIIAIELAMGEPPHLRMPPLKAMYTISSKAPPRL-
PAK1_Spur GTPYWMAPEVVTRKQYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPDIH
CC1G_15304_Ccin GVLYWQAPEVRSPPYNAMKVDVWSLGATVWEMAETQPPFADTNEFG-------DRWPPLS
CC1G_00840_Ccin GTPYWMAPEVVTRKEYGPKVDIWSLGIMAIEMIEGEPPYLNQNPLKALYLIATNGTPTIA
CC1G_02087_Ccin GTPYWMAPEVVKQKEYGAKVDIWSLGIMAIEMIENEPPYLDEEPLKALYLIATNGTPTLK
AqueK235_Aque GTPYWMAPEVVTRKQYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQ
GK081_Glam GTPFWMAPELIRGTEYNTKVDCWSLGIVVLELCESLPPHMEMQPLKAVFKIVTSPAPSFK
*. : :**: *:* ** * *: **. . *
PAK3_Hsap NPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKL-AKPL--SSLTPLIIAA----K
PAK2_Hsap NPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFLKL-AKPL--SSLTPLIMAA----K
PAK1_Hsap NPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQVRKLRF-QV-F--SNFSMIAASI----P
PAK3_Mmus NPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKL-AKPL--SSLTPLIIAA----K
PAK2_Mmus NPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFLKL-AKPL--SSLTPLILAA----K
PAK1_Mmus NPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKI-AKPL--SSLTPLIAAA----K
pak-1_Cele GRDSMTLLFKDFVDSALEVQVENRWSASQLLTHPFLRC-AKPL--ASLYYLIVAA----K
STE20_Scer EPENLSSSLKKFLDWCLCVEPEDRASATELLHDEYITEIAEAN--SSLAPLVKLA----R
SKM1_Scer HPESVSKQTKQFLDACLQVNVESRASVRKLLTFEFLSM-ACSP--EQLKVSL--------
CLA4_Scer HPESLSLEIKRFLSVCLCVDVRYRASTEELLHHGFFNM-ACDP--KDLTSLLE-------
Pak3_Dmel SWDKLSPNLQDFLDRCLQVEVDRRATADELLSHPFLND-CSEV--KALVPNIKAA----K
Pak_Dmel EKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFLKL-ARPL--ASLTPLIMAA----K
Y38F1A.10_Cele QRDRLSSEFNNFLDKCLVVDPDQRADTTELLAHPFLKK-AKPL--SSLIPYIRAV----R
PakA_Ddis DAHKWSKEFNDFLALCLEKDTEKRASSSSLLHHPFLKR-ACSG--PEFYKAVDAA----R
PakB_Ddis DQNKWSDDFKDFVKKCLDKDVENRPEAKVLLNHPFLKT-ACNS--NGLVPAIMEA----K
PakC_Ddis ETTKWSKTFQDFFSKCLDINVANRPDATDLLKHPFMDL-ACDS--SEFKPLIQAA----R
PakD_Ddis EPNKWSSDFIEFVNLCLNLDDKRRPDAHYLLRHPFLKK-ACSS--REFADKVEEI----Y
19075_Tthe DATKFSQEACDFVSTCLNIDPQERPTAQQLISHPFIQK-HCKS--RDQSKILLADLLLQK
25909_Tthe DPANFTQNFCNFVEQCLQKNPDERASFQTLLEHPFLKN-VPADAASKFASMVQN-----K
PAK1_Spur NPDRLSPVFRNFLAKCLETDVDKRADGEMLLKHPFLST-AKPL--NSLKPLIAAA----R
CC1G_15304_Ccin RPQLVSPAFHEFLRLCSEP-AASRPTAGELLKTPFVKN-ACGR--AVIVQLLSQC----I
CC1G_00840_Ccin NPENLSPVFTDYLAKTLEVDAEKRPSATELLQHPFFKL-SEPL--RTLAPLIKAA----R
CC1G_02087_Ccin KPEALSKELKSFLAVCLCVDVASRATAIELLDHEFLKK-ACQL--SGLAPLLRFK----T
AqueK235_Aque NPENLSRVFRDFLDRCLEMEVDKRGSASELLTHVFLKK-AAPL--SSLTPLIIAA----K
GK081_Glam KPSQWTPELNDFLARCLDKDPDSRWSCAQLLEHPWIKS-VDNA--P----L---------
: :. * *: .
PAK3_Hsap E--------------------------------------------AIK-----------N
PAK2_Hsap E--------------------------------------------AMK------------
PAK1_Hsap EDCQAP-----------------------------------LQPHSTD------------
PAK3_Mmus E--------------------------------------------AIK-----------N
PAK2_Mmus E--------------------------------------------AMK------------
PAK1_Mmus E--------------------------------------------ATK------------
pak-1_Cele K--------------------------------------------SIA----------EA
STE20_Scer LK-KVAENMDADEDNDDDNDNEHINKTNNCDDNNDSKETVNLDVTE------------DD
SKM1_Scer ------------------------------------------------------------
CLA4_Scer ------------------------------------------------------------
Pak3_Dmel K--------------------------------------------VLR------------
Pak_Dmel E--------------------------------------------AT-------------
Y38F1A.10_Cele ------------------------------------------------------------
PakA_Ddis I--------------------------------------------EKEN--QLQNF-ANL
PakB_Ddis K--------------------------------------------AKEA--H-----SKF
PakC_Ddis ------------------------------------------------------------
PakD_Ddis N--------------------------------------------TRKN--QFS---DIN
19075_Tthe K--N-----------------------------------------IKQSLIDFDQEANPI
25909_Tthe K--N-----------------------------------------IPLN--QL--FNIPK
PAK1_Spur E--------------------------------------------A--------------
CC1G_15304_Ccin A--------------------------------------------IE------------S
CC1G_00840_Ccin E---------------------------------------------------------IA
CC1G_02087_Ccin -----------------------------------------------K------------
AqueK235_Aque E--------------------------------------------M-A------------
GK081_Glam ---------------------------------------------D------------LS
PAK3_Hsap SSR
PAK2_Hsap SNR
PAK1_Hsap CCS
PAK3_Mmus SSR
PAK2_Mmus SNR
PAK1_Mmus NNH
pak-1_Cele SNS
STE20_Scer KQK
SKM1_Scer KWH
CLA4_Scer WKE
Pak3_Dmel RNV
Pak_Dmel KGN
Y38F1A.10_Cele -EK
PakA_Ddis TAI
PakB_Ddis SIH
PakC_Ddis -NV
PakD_Ddis FNF
19075_Tthe DSN
25909_Tthe DKQ
PAK1_Spur PKH
CC1G_15304_Ccin AFE
CC1G_00840_Ccin KNK
CC1G_02087_Ccin QAS
AqueK235_Aque GKR
GK081_Glam DYF