PRP4_Hsap MAAAETQ-SLREQ-PEMEDA-NSEKSINEENGEVSEDQSQN--KHSRHKKKKHKHRSKHK
PRP4_Mmus MAATEPP-SLREQ-AEMDDADNSEKSVNEENGEVSEDQSQN--KHSRHKKKKHKHRSKHK
F22D6.5_Cele MEDNRV-EEDGEVKSDVG--TSSDEKASDSEVEKRQRTDSE--RSGKDKKKKHKKEKKHK
Prp4_Ddis MVIESEI-NDKKRG--LES--SSPTI-ND---PKKVKV----------------------
15575_Tthe MSDKQKKKEDGELSGEEDEYKSPKQKKSDKDDRKKSKRSSRSHSSRRTNDKISDSTKSNK
PRP4_Spur MSSNSAS-EEEN----VK--GGAPAS-----KEDSGKQRSH--SSSRHKKHKHKSKKSHH
CG7028_Dmel MADDKSY-DSS----------------------------NN--SETEERRAKHKKAKKHK
CC1G_04865_Ccin MADASPA-PVEEP--EEETA-PTPPQKSEEE-----------------------------
AqueK115_Aque ------------------------------------------------------------
AqueK116_Aque MDSCIFV-IMA------------------------------------ERKLSTG------
PRP4_e_Smoe MGRKRR-SEDCQIS----------------------------------------------
PRP4_d_Smoe MGRRKR-SENYQIR----------------------------------------------
PRP4_b_Smoe MARDGRV-DDAKDK------SRKRKSVEDEQP-----SSKR--REDDDGKRKHK----HR
PRP4_a_Smoe MARDGRV-DDAKDK------SRKRKSVEDEQP-----SSKR--REDDDGKRKHK----HR
PRP4_c_Smoe MFSETP-LT---------------------------------------------------
PRP4_Hsap KHKHSSEEDKDKKHKHKH------KHKKHKRK--EIIDASDKEGMSP-AKR---------
PRP4_Mmus KHKHSSEEDRDKKHKHKH------KHKKHKRK--EVIEASDKEGLSP-AKR---------
F22D6.5_Cele KDKKHK------------------KEKKHKRE--KEVEM-ENDG-PP-AKKRT-------
Prp4_Ddis ------------------------------------------------------------
15575_Tthe KDKDHK-DSSRRRSKSRSKDRKDQQKRKYSRS--RSRSY-PNDR-NG-TKQRH-------
PRP4_Spur KHKHHK-ENKDGHRRHKH------KHKKHKSK--KDEEP---PVATP-AADESESDIELE
CG7028_Dmel KHKKSST-GKTEKDRHVH------KKQKKAKKRPHRTSESTNESDAPENAKLKL-----S
CC1G_04865_Ccin ------------------------------------------------------------
AqueK115_Aque ------------------------------------------------------------
AqueK116_Aque -DVP-PV-LRTD------------------------------------------------
PRP4_e_Smoe ------------------------------------------------------------
PRP4_d_Smoe ------------------------------------------------------------
PRP4_b_Smoe K------------HKHRS------SHRKHSSK--EADL--DANV-VP-AAMA--------
PRP4_a_Smoe K------------HKHRS------SHRKHISK--EVDL--D--V-VP-AAMA--------
PRP4_c_Smoe ------------------------------------------------------------
PRP4_Hsap ------------------------------------------------------------
PRP4_Mmus ------------------------------------------------------------
F22D6.5_Cele ------------------------------------------------------------
Prp4_Ddis ------------------------------------------------------------
15575_Tthe ------------------------------------------------------------
PRP4_Spur DTIPLPKFEPKIPPP----------------------------PPPPNSRRESGRKE---
CG7028_Dmel Q-------------NCGLSSKFTEIMQKASRNGADFRVGKPLLPTDPSSLVEEITKTIQN
CC1G_04865_Ccin ------------------------------------------------------------
AqueK115_Aque ------------------------------------------------------------
AqueK116_Aque ------------------------------------------------------------
PRP4_e_Smoe ------------------------------------------------------------
PRP4_d_Smoe ------------------------------------------------------------
PRP4_b_Smoe ------------------------------------------------------------
PRP4_a_Smoe ------------------------------------------------------------
PRP4_c_Smoe ------------------------------------------------------------
PRP4_Hsap ---------------------------TKLDDLALLEDLEKQRALIKAELDNELMEGKVQ
PRP4_Mmus ---------------------------TKLDDLALLEDLEKQRALIKAELDNELMEGKVQ
F22D6.5_Cele ------------------------------------------------------------
Prp4_Ddis ------------------------------------------------------------
15575_Tthe ------------------------------------------------------------
PRP4_Spur --------------------------RGRGGD-DTLAALEKQKELLQAQLLATAED--EH
CG7028_Dmel KMLPVLEVASSSSESDVPADAASPIILSIIEDELNLEELMRQKALLQARLGAYMSDPE--
CC1G_04865_Ccin ----------------------------------ILAERRARRAAIKAKYEGSRSVVDTA
AqueK115_Aque ------------------------------------------------------------
AqueK116_Aque -------------------------------DQ---------------------------
PRP4_e_Smoe ------------------------------------------------------------
PRP4_d_Smoe ------------------------------------------------------------
PRP4_b_Smoe ------------------------------------------------------------
PRP4_a_Smoe ------------------------------------------------------------
PRP4_c_Smoe ------------------------------------------------------------
PRP4_Hsap SGMGLILQGYESGSEEEGEIHEKARNGNRSS------------------TRSSSTKGKLE
PRP4_Mmus SGMGLILQGYESGSEEEGEIHEKARNGNRSS------------------TRSSSTRGKLE
F22D6.5_Cele ----------------------------------------------------------LE
Prp4_Ddis -------ESPS-SGKEDGEVDEVTSSP---A------------------SRE--------
15575_Tthe ----------------------------------------------------------LD
PRP4_Spur SGMNLIAQGYQS-DEEEGEDDESALKQSLSKWI---------------------------
CG7028_Dmel -------------AEDKGDLLPHT----HSQQLVVHTKSVLKAVTSVPQPQPSKSAAPLA
CC1G_04865_Ccin --PGTPN------------------------------------------PAT--GSQALS
AqueK115_Aque ------------------------------------------------------------
AqueK116_Aque ------------------------------------------------------------
PRP4_e_Smoe ------------------------------------------------------------
PRP4_d_Smoe ------------------------------------------------------------
PRP4_b_Smoe ------------CEAEDGEILEPTEDG---------------------------------
PRP4_a_Smoe ------------CEAEDGEILEPTEDG---------------------------------
PRP4_c_Smoe ------------------------------------------------------------
PRP4_Hsap LV--DNKITTKKRSKSRSKERTRHRSDKKKSKGGIEIVKE-KTTRSKSKERK---KSKSP
PRP4_Mmus IT--DNKNSAKKRSKSRSKERTRHRSDKRKSKGAGEMLRE-KANRSKSKERR---KSKSP
F22D6.5_Cele EVD---------------------------------------------------------
Prp4_Ddis TSS--SKLMSPSKNQSSSSSRSYHDSNN------GYRRKDERYSSSRS-----------Y
15575_Tthe NLY---------------------------------------------------------
PRP4_Spur -R--PESSSSKPSSKSELKDSE--RSEKRKREREDETSQK-KQHRSKSPATE---RSSGS
CG7028_Dmel TA--TSKHANIKKST-------THNSNE-----SDVILLD--------------------
CC1G_04865_Ccin TISTTAPSASGTPSG-------VVNEAM-----SKVTLAG-D--------------PGTP
AqueK115_Aque ------------------------------------------------------------
AqueK116_Aque ------------------------------------------------------------
PRP4_e_Smoe ------------------------------------------------------------
PRP4_d_Smoe ------------------------------------------------------------
PRP4_b_Smoe -----------------------------------IVLKEE-GNGSSESEKD--------
PRP4_a_Smoe -----------------------------------IVLKEE-GNGSSESEKDVEQEIEAP
PRP4_c_Smoe ------------------------------------------------------------
PRP4_Hsap SK----------RSKSQ-DQARKSKSPTLRRRSQEKIGKARSPTD---------------
PRP4_Mmus SK----------RSKSQ-DQARKSKSPPLRRRSQEKVGKARSPAE---------------
F22D6.5_Cele ------------------------------------------------------------
Prp4_Ddis DR----------------------------------------------------------
15575_Tthe ------------------------------QRTQIKNGKCNQIYGSQKRNTKFSNDKFLF
PRP4_Spur SR----------V-DNG-------------------------------------------
CG7028_Dmel ------------------------------------------------------------
CC1G_04865_Ccin TV----------STPGPEFLQRGSASPPP-------------------------------
AqueK115_Aque ------------------------------------------------------------
AqueK116_Aque ------------------------------------------------------------
PRP4_e_Smoe ------------------------------------------------------------
PRP4_d_Smoe ------------------------------------------------------------
PRP4_b_Smoe ------------------------------------------------------------
PRP4_a_Smoe KSERGSPRRSRDGSPPRDNVDRKHSSPDRRH-----------------------------
PRP4_c_Smoe ------------------------------------------------------------
PRP4_Hsap ----------------------DKVKIEDKSKSKDRKKSPIINESR-SRDRGKKSRSPVD
PRP4_Mmus ----------------------EKMKSEEKGKIKDRKKSPIVNE-R-SRDRSKKSKSPVD
F22D6.5_Cele -------------------------TKKDESKKKEAKESSRNNEDEL--------RNP--
Prp4_Ddis -----------------------NYRDRDISRDGDRER----------------------
15575_Tthe SNSKNLSEAFYIDSYFYSLNSSKKDKDRDNAKEKDRKRSKSPTKDKDRKNDRKRSKSPRS
PRP4_Spur ----------------------------------DAKS---------SQSRTNRDSHIAS
CG7028_Dmel -----------------------------DSSGGQRTPSPTPEK-R-RRHASPLPAAP--
CC1G_04865_Ccin ----------------------------------------------------------TS
AqueK115_Aque ------------------------------------------------------------
AqueK116_Aque ------------------------------------------------------------
PRP4_e_Smoe ------------------------------------------------------------
PRP4_d_Smoe ------------------------------------------------------------
PRP4_b_Smoe ------------------------------------------------------------
PRP4_a_Smoe ------------------------------------------------------------
PRP4_c_Smoe ------------------------------------------------------------
PRP4_Hsap L-RGKS--KDRRSRSKERKSKRSETDKEKKPIKSPSKDASSGKENRSPSRRPGRSPKR-R
PRP4_Mmus L-RDKS--KDRRSRSKERKSKRSEIDKEKKPIKSPSKDASSGKENRSPSRRPGRSPKR-R
F22D6.5_Cele -----P--RRERSKSAE-------------------------------------------
Prp4_Ddis ------------DRDRERDRDR--------------------------------------
15575_Tthe SNNGKR--KSSRSKSPKRE------------------------------------DS---
PRP4_Spur D-RKHS--KDSDSRRDSRKSSPSATKSEQR----ESRDSREPRDSRKSSGRDGRASPK-R
CG7028_Dmel --RSRC-RRDRRSRDRDRS------------------------------------PPR-R
CC1G_04865_Ccin A-ADQN---FELAKDGEDDAKRGEIIA---------------------------------
AqueK115_Aque ------------------------------------------------------------
AqueK116_Aque ------------------------------------------------------------
PRP4_e_Smoe ------------------------------------------------------------
PRP4_d_Smoe ------------------------------------------------------------
PRP4_b_Smoe -------------------------------------------------------NARHH
PRP4_a_Smoe --RGSSVDRKRRSRSKESVR----------------------------------ENARHH
PRP4_c_Smoe ------------------------------------------------------------
PRP4_Hsap SLSPKPRDKSRRSRSPL-LND-RRSKQSKSPSRTLSPGRR-AKSRSLERKR---REPERR
PRP4_Mmus SLSPKLRDKSRRSRSPL-LND-RRSKQSKSPSRTLSPGRR-AKSRSLERKR---REPERR
F22D6.5_Cele ----------RRDRE---LRE-RRDA--ERRDRSLSKERR-LIQRKREDNR---RDPRAH
Prp4_Ddis ----------DRDRDRDRDRD-RDRERDRDRDR--------DRDRDRDRDRDRDRERERE
15575_Tthe ----------RRDKD---SKSGYRDN--EKKSN-YGSNRDRESRRSEENNT---RESKQL
PRP4_Spur ELK--SGEKSRRESSR----D-SKPIRSRSPKKERVFTEP-ARSRPSPPRR---SPPPRR
CG7028_Dmel RASDQQ--TQVR--------------------------PR-SRNRNMEDLR---QEINRD
CC1G_04865_Ccin -----------NAAEPA-GGD-QINAAD------YDP------SL----DR---REDERK
AqueK115_Aque ------------------------------------------------------------
AqueK116_Aque ------------------------------------------------------------
PRP4_e_Smoe ------------------------------------------------------------
PRP4_d_Smoe ------------------------------------------------------------
PRP4_b_Smoe SRVASPDRKRRRSKSRDR-GD-ERSR-----RHAYSPDRR-RRSRSREHDE---R-----
PRP4_a_Smoe SRVASPDRKRRRSRSRDR-GD-ERSR-----RHAYSPDRR-RRSRSREHDE---R-----
PRP4_c_Smoe ------------------------------------------------------------
PRP4_Hsap RLSSPRTRPRDDILSRRERSKDASPINRW-SPTRRRSRSP-IRRR---SRSPLRRSRSPR
PRP4_Mmus RLSSPRTRPRDDILGRCERSKDASPINRW-SPTRRRSRSP-IRRR---SRSPLRRSRSPR
F22D6.5_Cele EGN-----RRRDR-------------------------TPE------------RFRNNRD
Prp4_Ddis RD--------------RDR-----------NSQERGSRNS-HERDYRD------------
15575_Tthe TLE--EEEERNDR---YYNDFDDSDSDYYQRVNDRKY-KSSRRSK---S----RSKNRDR
PRP4_Spur PPSPPARR-PDQPLGRRGR-----------SPIERRGRSP-LERRIRSSRSPAVVDRFDR
CG7028_Dmel KQRERRDHS---------RDRDRRGLDRPPPPTDMR---P-GRAR---ERD-VRPSRMQR
CC1G_04865_Ccin RFG--------------------------------------------------------V
AqueK115_Aque ------------------------------------------------------------
AqueK116_Aque ------------------------------------------------------------
PRP4_e_Smoe ------------------------------------------------------------
PRP4_d_Smoe ------------------------------------------------------------
PRP4_b_Smoe -------------------------------------------------------EKYPR
PRP4_a_Smoe -------------------------------------------------------EKYPR
PRP4_c_Smoe ------------------------------------------------------------
PRP4_Hsap RRSRSPRRR---DRGRRSRS-RLRRRSR-SRGGRR------------------RRSRS--
PRP4_Mmus RRSRSPRRR---DRSRRSRS-RLRRRSR-SRGGHR------------------RRSRS--
F22D6.5_Cele RRDRDGRRE---DRHRRSPD-RRRDSDR-KREDGK------------------R------
Prp4_Ddis -------NR---DYSRDSRD-NMDSRDN-KNGSRQSINNNTLSYEKQADRKDEVRVKDNI
15575_Tthe KKSKSKGRK---DDKNKDKD-KERSKNS-GNGDNS------------------K------
PRP4_Spur RRGASPPRRFG-DM-SRNRRRWSRSPDRRGRRGRW------------------GRSRS--
CG7028_Dmel SHSRSKFES---DR-RR--E-RERQKDR-DRGGGR------------------VGARSGT
CC1G_04865_Ccin ------------DQ--------------AANGT---------------------------
AqueK115_Aque ------------------------------------------------------------
AqueK116_Aque ------------------------------------------------------------
PRP4_e_Smoe ------------------------------------------------------------
PRP4_d_Smoe ------------------------------------------------------------
PRP4_b_Smoe KRAESRDRHIKDDRGARDDE-RHYNRDR-SRQ-----------------------N----
PRP4_a_Smoe KRAESRDRHIKDDRGARDDE-RHYNRDR-NRR-----------------------DRE--
PRP4_c_Smoe ------------------------------------------------------------
PRP4_Hsap -KVKEDKFKGSLSEGM---KVE-QESSSDD---NLEDFDV-E--EEDEEALIEQRRIQRQ
PRP4_Mmus -KVKEDKFKGSLSEGM---KVE-QESSSDD---NLEDFDV-E--EEDEEALIEQRRIQRQ
F22D6.5_Cele ----------------------KDESKDVE---W--NLDS-D--SDDEQKKIEAARKRRI
Prp4_Ddis S-VNDDKT--NHGENLTNESI-TATSTNEP---TKPAVIIEEDEETKTKRILEENRLQRQ
15575_Tthe --SSKDKKE---EEA---KKAQQPETIDDD---EDLNMEI-E--DSD-----DERERKKQ
PRP4_Spur -KSPRDKFKGSLSEGL---SLK-QESSDDE----IPDVDLDE--EEDEEAVIERRRRERQ
CG7028_Dmel DNGDRDRYKGSLSEGQ--NKLD-KESSDEE---VNVNIDILE--EDDEERIIELRRKKRE
CC1G_04865_Ccin ----NHHVNGQSGSAI---DVD-MEDEDED---DEADEES-E--EEDLDD----------
AqueK115_Aque ------------------------------------------------------------
AqueK116_Aque ---------------------------------------LMS--EDEVKEIK--------
PRP4_e_Smoe ---------------------------------------VVEDEDAMVERVREESRKRRQ
PRP4_d_Smoe ---------------------------------------VEEDEDAMVERVREESRKRRQ
PRP4_b_Smoe --------------------------QDEYLERVAHQLA-EQ--EEDIEKVKEESRKRRQ
PRP4_a_Smoe -ELS-EKQETTQSETI---ERE-EENQDEYLERVAHQLA-EQ--EEDIEKVKEESRKRRQ
PRP4_c_Smoe ------------------------------------------------------------
PRP4_Hsap AIVQKYKYL---AEDSN-----M----SVP------SEPSS--------PQSSTRT--R-
PRP4_Mmus AIVQKYKYL---AEDSN-----I----SVP------SEPSS--------PQSSTRS--R-
F22D6.5_Cele QIIKKIEGH---TEENTP-RDSS----TPR------SDTIGDKKTDESEDSSS-------
Prp4_Ddis LIMEKYNKE---QPQPIT-SSLS----TTE------KEQSNTNTNSNSTPVATTTT--SI
15575_Tthe EFLNMIKVQGMQMQKQEA-SQTF----SKE------NNQNNQTQNKNDQDVVDDKL--K-
PRP4_Spur QLMQKYKVA---PAESAT-SSPA----QGP------SEPSST----PQSPQASEQGGST-
CG7028_Dmel ELLKKLGTG---QESPAP-HNSV----SYE------SRSTSQGSSQRERPLRTPSP--T-
CC1G_04865_Ccin ------------------------------------------------------------
AqueK115_Aque ------------------------------------------------------------
AqueK116_Aque ------------------------------------------------------------
PRP4_e_Smoe AILEKHALE---EGQIIE-QQSVSLGNPVP------HDTAK--------I----------
PRP4_d_Smoe AILEKHALE---EGQIVE-QESVSLGNPVP------HDTAK--------I----------
PRP4_b_Smoe AILEKHKMQ---QNSG-------------------------EGIIDPSTPLSLGKS--A-
PRP4_a_Smoe AILEKHKMQ---QSQPEEPAETM----KVSKPLTAAEPDSGEGIIDPSTPLSLGKS--A-
PRP4_c_Smoe ------------------------------------------------------------
PRP4_Hsap -S-PS-----PD----DILE----------------------------------------
PRP4_Mmus -S-PS-----PD----DILE----------------------------------------
F22D6.5_Cele ---DS-----ED----DE---DDRKLAEAKDLIKST-RFGSEQGSGASTPVSIQSDNDTP
Prp4_Ddis LA-KS-----PS----NLENQIEEEDESI-------------------------------
15575_Tthe -VKDS-----ENLENQNF---ADENSEEQ------L-F---------------DDTGLNP
PRP4_Spur -A-QSQDTDDED----DDEE-EEEEDEEE------DDSE--------------KSSSSDS
CG7028_Dmel -M-PC-----PN----PLIS----------------------------------------
CC1G_04865_Ccin ------------------------------------------------------------
AqueK115_Aque ------------------------------------------------------------
AqueK116_Aque ------------------------------------------------------------
PRP4_e_Smoe ------------------------------------------------------------
PRP4_d_Smoe ------------------------------------------------------------
PRP4_b_Smoe -L-PN-----G-----TILK----------------------------------------
PRP4_a_Smoe -L-PN-----G-----TILK----------------------------------------
PRP4_c_Smoe ------------------------------------------------------------
PRP4_Hsap -----RV-A-----------------------AD----V----K----EYERENVDTFE-
PRP4_Mmus -----RV-A-----------------------AD----V----K----EYERENVDTFE-
F22D6.5_Cele TDFFSGL-RDKMVHMKDADEHNVDEVLQ-----R----G--K-D----EEYREDWHTQLK
Prp4_Ddis ------I-I---EWRKDQNSENSSAFNDNNNDES----C--SSE----EDLKKRGKIKE-
15575_Tthe NDVLDDDDVNIANTINDDYKEEVDESHS-----LTHRHSIDK-AQLDHLKFLED----MR
PRP4_Spur DDDSSEV-ESKASSDDDDDDEEDDEGDA----AR----I----E----EEERLREEEEE-
CG7028_Dmel -----EI-P-----------------------K-----------------DREDMDNS--
CC1G_04865_Ccin -------------------------MFA----VA----L--G-G----DEEK--------
AqueK115_Aque ------------------------------------------------------------
AqueK116_Aque ------------------------------------------------------------
PRP4_e_Smoe ------------------------------------------------------------
PRP4_d_Smoe ------------------------------------------------------------
PRP4_b_Smoe -----RNA------------------------GG----L----G----EGSPPKVR----
PRP4_a_Smoe -----RNA------------------------GG----L----G----EGS---------
PRP4_c_Smoe ------------------------------------------------------------
PRP4_Hsap --------------ASVKAKH-----------------------------------NLMT
PRP4_Mmus --------------ASVKAKH-----------------------------------NLMT
F22D6.5_Cele E----------QEKREEEEKKKKLEAEAAA-------------EA---------------
Prp4_Ddis --------------EDIKAKDKPITTTTTTTT----------IN------------NVSI
15575_Tthe NQEIKGGIPDMPEQPILKQKRKSINSEKLEGKFSNNDQLDEENKL---------------
PRP4_Spur --------------AE-QEKRREMERKRLKEAFPQSDSEDEESAANSKKGEGSLDKNLSD
CG7028_Dmel ------------------------------------------------------------
CC1G_04865_Ccin --------------PK-KKKKKATGKKK--------------------------------
AqueK115_Aque ------------------------------------------------------------
AqueK116_Aque ------------------------------------------------------------
PRP4_e_Smoe ------------------------------------------------------------
PRP4_d_Smoe ------------------------------------------------------------
PRP4_b_Smoe ---------------------------------------------------ICLRKNLL-
PRP4_a_Smoe ------------------------------------------------------------
PRP4_c_Smoe ------------------------------------------------------------
PRP4_Hsap VEQN---NGSSQKKLLAPDMFTESDDMFA--AYFDSARLRAAGIG---KD-FKENPNLRD
PRP4_Mmus VEQN---NGSSQKKILAPDMFTESDDMFA--AYFDSARLRAAGIG---KD-FKENPNLRD
F22D6.5_Cele ----AK-KKKQEEDDTGFDMFADNEE---------LPQDSTTIDG---HS-GAVHDTLKD
Prp4_Ddis KLPPKPEPIKAKTSAPVFDMFSDSPSDETDESNRDLNETNGGGVMVDANIVVNPSINLSD
15575_Tthe ----HK-LDDQEDSEEETDMFGDDID---------KIINKS-NDG---KL-QIVK-GANA
PRP4_Spur IVKPKS-DKEQAMANNGLDMFSEVDM-FK-----MSP-STREGIG---QM-GPENPSLTD
CG7028_Dmel TSQK---TCSAKEKRNEWDMFADQDVDS----NFDSPN--TIVQN---KH-QHENPALTD
CC1G_04865_Ccin ---------------------------------------TKENAA---QT-LGAPNVIVD
AqueK115_Aque ------------------------------------------------------------
AqueK116_Aque ---T---GLSAMKTAVVLDIFSEEDITGKE-KSWLSPS--KALLA---DG-IGENDHLTD
PRP4_e_Smoe -ASN---SCDKSSSPPAQDMFSETPLAEIT-----NP----EASV---Q---GLRNDNPD
PRP4_d_Smoe -ASN---SCDKSSSPPAQDMFTETPLAEII-----NP----EASG---Q---GVRNDNPD
PRP4_b_Smoe I--SSS-LQSEKPADMFCDIFGESPA-----------EIRKAGTR---DTLAIDTSGLTD
PRP4_a_Smoe -----P-PKSEKPADMFCDIFGESPA-----------EIRKAGTR---DTLAIDTSGLTD
PRP4_c_Smoe ---------------------------EIT-----NP----EASV---Q---GLRNDNPD
PRP4_Hsap NWTDAEGYYRVNIGEVLDK-RYNVYGYTGQGVFSNVVRARDNA--------------RAN
PRP4_Mmus NWTDAEGYYRVNIGEVLDK-RYNVYGYTGQGVFSNVVRARDNA--------------RAN
F22D6.5_Cele NWDDVEGYYRVRIGELLDT-RYRVVGFTGAGVFGNVCRCNDQT--------------KG-
Prp4_Ddis NWDDADGYYKFRVGEIMD--KYQIFSPIGSGVFSTVVSAKETK---------------TN
15575_Tthe ECDDEQNYFKILIGEVLNG-KYRVIQKCGKGVFANVCKAEQLD--------------NG-
PRP4_Spur NWDDEEGYYRVRIGESLDK-RYAVYGYTGQGVFSNVVRARDTA--------------RGK
CG7028_Dmel NWDDAEGYYRVRIGEVLDN-RYLVNGYTGQGVFSNVVRGRDQA--------------RGQ
CC1G_04865_Ccin AAADPEGYYRVILGERIDNGRYQVFSSLGQGMFANVVRARVLKDENGKDLAVDGVAPESL
AqueK115_Aque ----------VRIGEQLDR-RYMVYGYTGQGVFSNVVRARDTS--------------RSS
AqueK116_Aque NWDDAEGYYRVRIGEQLDR-RYMVYGYTGHGVFSNVVRARDTS--------------RSS
PRP4_e_Smoe NWHDHEFYYKARIGETINS-KYQVKASIGSGMFSTVFLAKSLFP-------------ECE
PRP4_d_Smoe NWHDQEFYYKARVGETINS-KYQVKASIGSGMFSTVFLAKSLLP-------------ECQ
PRP4_b_Smoe NWDDADGYYTYRVGEVLDN-RYEIASSHGRGVFSTVVRARDTKAGR-----------GEP
PRP4_a_Smoe NWDDADGYYTYRVGEVLDN-RYEIASSHGRGVFSTVVRARDTKAGR-----------GEP
PRP4_c_Smoe NWHDHEFYYKARIGETINS-KYQVKASIGSGMFSTVFLAKTLLP-------------ECE
:** :: :* : * *:*..* .
PRP4_Hsap QEVAVKIIRNNELMQKTGLKELEFLKKLNDA--DPDDK-FHCLRLFRHFYHKQHLCLVFE
PRP4_Mmus QEVAVKIIRNNELMQKTGLKELEFLKKLNDA--DPDDK-FHCLRLFRHFYHKQHLCLVFE
F22D6.5_Cele NTVAVKIIRNNEVMYKTGLRELEVLRKLNEA--DKEDK-YHCLRLFRTFKHHNHLCLVFE
Prp4_Ddis EDVVIKIIRNRPSMHRSGLKEIEILQKISNTPTSSNQK-SHCIQMKDHFNYRNHLCIVFE
15575_Tthe KMVAIKILRSNEIMRDSGEREKEIIQKLNLN--DKNDR-KHIVRLKNVFEHQKHMCLVFE
PRP4_Spur LDVAIKIIRNNDLMQKTGMKELEYLKRLNDQ--DREDK-FHCVRLFRSFSYRQHLCLVFE
CG7028_Dmel ANVAIKIIRNNEIMHKTGLRELEILKKLNDA--DPEDR-FHCLRLYRHFFHKQHLCMVFE
CC1G_04865_Ccin REVAIKIIRSQESMYKAGLKEAQILQKLRAL--DPEDK-KHIVKLERTFEHRGHLCLVFE
AqueK115_Aque QEVAIKIIRNNEMMHKTGMAELEILKKLNAT--DPDDK-FHCIRLFSNFFHKNHLCLVFE
AqueK116_Aque QEVAIKIIRNNEMMHKTGMAELEILKKLNAT--DPDDK-FHCIRLFSNFFHKNHLCLVFE
PRP4_e_Smoe QEVAIKIPRKNDLMLRSAKSELQILKKVAEP--EATNKDNHCVKLLDSFVYREHLCLVME
PRP4_d_Smoe QEVAIKIPRKNDLMLRSAKSELQILKKVAEP--EATNKDNHCVKLLDSFVYREHLCLVME
PRP4_b_Smoe EEVAIKIIRSNETMFKAGQMELIILNKLAGA--DLENK-RHCVRLLSSFEYRNHLCLVFE
PRP4_a_Smoe EEVAIKIIRSNETMFKAGQMELIILNKLAGA--DLENK-RHCVRLLSSFEYRNHLCLVFE
PRP4_c_Smoe QEIAIKIPRKNDLMLRSA-------------------------------KYREHLCLVME
:.:** *.. * :. :: *:*:*:*
PRP4_Hsap PLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKT
PRP4_Mmus PLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKT
F22D6.5_Cele NLSMNLRELLKKYGQKDGLHLKAVRSYAQQLLLALRLLKKLEFVHADIKPDNILVNESKL
Prp4_Ddis PMSMSLHQLIKKYGKDIGLSLNAVRVYAKQLFLALKHIKNSKILHADIKPDNIVVNEAKN
15575_Tthe CFAMNLRDALKEYGKGKGFSLDVVRSYAYQIFVALTHLKKNNYIHADLKPDNLLISEDTK
PRP4_Spur PLSMNLREVLKRYGKDVGLHIKAVRSYTQQLFLALKLLKRCNILHADIKPDNILVNESKS
CG7028_Dmel PLAMNLREVLKKYGKNVGLHIKAVRSYTQQLFLALKLLKKTGILHADIKPDNILVNENNL
CC1G_04865_Ccin NLSMNLREVVKRFGKDVGLNIRAVRAYAHQLFLALSLLRKANIMHADIKPDNILVNEQKN
AqueK115_Aque SMSMNIREVLRKYGKNIGLHIKAVRSYSQQLLLALKLMKRCTILHADIKPDNILVNESKL
AqueK116_Aque SMSMNIREVLRKYGKNIGLHIKAVRSYSQQLLLALKLMKRCTILHADIKPDNILVNESKL
PRP4_e_Smoe SLDLNLRQITNKYGRNRGINLKTICVYAHQLMVALQHLAHCGILHCDIKPDNIMVTKSRR
PRP4_d_Smoe FLDLNLRQITNKYGRNRGINLKTICVYAHQLMVALQHLAHCGILHCDIKPDNIMVTKSRR
PRP4_b_Smoe SLHMNLREILKKFGRNIGISLAAVRSYARQLFTALKHLRNCGVLHCDIKPDNMLVNDSKN
PRP4_a_Smoe SLHMNLREILKKFGRNIGISLAAVRSYARQLFTALKHLRNCGVLHCDIKPDNMLVNDSKN
PRP4_c_Smoe SLDLNLRQITNKYGRNRGINLKTICVYAHQLMVALQHLAHCGIFHCDIKPDNIMVTKSRR
: :.::: ..:*: *: : .: *: *:: ** : . .*.*:****:::..
PRP4_Hsap ILKLCDFGSASHVADN---DITPYLVSRFYRAPEIIIGK-SYDYGIDMWSVGCTLYELYT
PRP4_Mmus ILKLCDFGSASHVADN---DITPYLVSRFYRAPEIIIGK-SYDYGIDMWSVGCTLYELYT
F22D6.5_Cele TLKLCDFGSAGRVNEQ---ELAPYLVSRFYRAPEIMLGV-RHDYAIDLWSVAVTLYEVYT
Prp4_Ddis TIKIVDFGSAGEIHES---EITPYLVSRFYRAPEIILGH-KYDYSIDVWSVGCCLAEFFT
15575_Tthe TLKMCDFGTALPIEEN---GIIKYLQSRFYRAPEVLIGY-PPYNQIDVWSVGVTLYEIYT
PRP4_Spur VLKLCDFGSASHVADN---DITPYLVSRFYRAPEIIIGM-NYDAAIDMWSTGCTIFELAA
CG7028_Dmel ILKLCDFGSASAISDN---EITPYLVSRFYRSPEIILGI-PYDYGIDTWSAGCTIYELYT
CC1G_04865_Ccin LIKLCDLGSASDASEN---EITPYLVSRFYRAPEIILGV-PYDPALDVWSIGCTLYELYT
AqueK115_Aque MLKLCDFGSASFIQDN---EITPYLVSRFYRAPE--------------------------
AqueK116_Aque MLKLCDFGSASFIQDN---EITPYLVSRFYRAPEIIIGC-KYDYGIDMWSVGATLYELYT
PRP4_e_Smoe SIKLCDFGVAMFARDQTPSAETPYLVSPSYRAPEIILGVAPYSHAIDMWSAGCCLYELYT
PRP4_d_Smoe SIKLCDFGVAMFARDQTPSAETPYLVSPSYRAPEIILGVAPYSHPIDMWSAGCCLYELYT
PRP4_b_Smoe LLKLCDFGSAMFAGEN---EITPYLVSRFYRAPEIILGL-PYDHALDMWSVGCCLYELYT
PRP4_a_Smoe LLKLCDFGSAMFAGEN---EITPYLVSRFYRAPEIILGL-PYDHALDMWSVGCCLYELYT
PRP4_c_Smoe SIKLCDFGVAMFARDQTPSAETPYLVSPSYRAPEIILGVAPYSHQIDMWSAGCCLYELYT
:*: *:* * :. ** * **:**
PRP4_Hsap GKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREK--
PRP4_Mmus GKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREK--
F22D6.5_Cele GKIMFPGRTNNHMLKLFTDVKGKYPNKLVRKSQFKDTHFDVNCNLLYQEVDKVTERNK--
Prp4_Ddis GKFLFPGKTNNDMIRLFMEYRGAFSKKMLKKSEFVSNHFNENLVFMKQEIDNIEKTVR--
15575_Tthe QKILFDGSTNNEMLKLIMDSRGKFNKKMLQNGKYVEEYFDQNYNFKYTYVDKQTNQKY--
PRP4_Spur GKIMFPGKTNNHMLKLFMDLKGKMPHKIIRKGILRDKHFDPNCNFKYVEVDKVTEREK--
CG7028_Dmel GKILFSGKSNNQMLKFFMDVKGKIPNRIIRKGQFREQHFDQSCNFLYHEIDKLTEREK--
CC1G_04865_Ccin GKILFPGRSNNQMLRLMMELKGRFNTKIIKKAKFGETYFDELGAFESVERDRLTGSDI--
AqueK115_Aque ------------------------------------------------------------
AqueK116_Aque GQILFPGKSNNEMLKLNMELKGKMSHKMVRKGMFRENHFDSSFNFLYHTVDKVTQKEK--
PRP4_e_Smoe GKFLFPVATNNGLLKQQMELKGAFPKAMLKKGAFTGMHFNENFEF--RQLDPVTKLET--
PRP4_d_Smoe GKFLFPVATNNGLLKQQMELKGAFPKAMLKKGAFTGMHFNENFEF--RQLDPVTKLET--
PRP4_b_Smoe GKVLFPGSTNNDMLRLHMELKGPFPKKMLRKAMFTAQHFDQDLNFHAIEEDPVTKKTI--
PRP4_a_Smoe GKVLFPGSTNNDMLRLHMELKGPFPKKMLRKAMFTAQHFDQDLNFHAIEEDPVTKKVQFC
PRP4_c_Smoe GKFLFPVATNNGLLKQQMELKGAFPKAMLKKGAFTGMHFNENFEF--RQLDPVTKLET--
PRP4_Hsap ----------------VTVMSTI-NPTKDLLADLIGCQ--RLPEDQRKKVHQLKDLLDQI
PRP4_Mmus ----------------VTVMSTI-NPTKDLLADLIGCQ--RLPEDQRKKVHQLKDLLDQI
F22D6.5_Cele ----------------ITVLANL-KPTRDLESELIAG--QRLSRDQMDQIQAFRTLLDGM
Prp4_Ddis ----------------KVPHDIT-KPTKDILQFLLPK-NVSIPDQDMKKLIQLKDLIEKC
15575_Tthe ----------------TTIITYGDIPKKDIYRLLQEN-KDGINLENQKKLSQFKDFLDKC
PRP4_Spur ----------------VTVMTVI-NPTKDLTTELLGYQ--RLPEDQQRKVLQLKDVLDRC
CG7028_Dmel ----------------IVVMPVV-KPSRSLQQELIADQ--NLPDDQHRKVTQLKDLLENM
CC1G_04865_Ccin ----------------TRKIHIQ-KPTRDLRARLMPSSSVKLNDEETKMLANFIDLLDKC
AqueK115_Aque ------------------------------------------------------------
AqueK116_Aque ----------------VVVMSSF-SPQRDLLADLVGSQ--SPSEAHLRKIHHFKDFLDKI
PRP4_e_Smoe ----------------LRSMASF-NVKTSCISDLTG--------EDGALMARFKNLLERM
PRP4_d_Smoe ----------------LRSMASF-NVKTSCISDLTG--------EDGALMARFKNLLERM
PRP4_b_Smoe ----------------NRMITNV-KP-KDI-STLISSS--GGSDEDAKNLLNFKLLLEKI
PRP4_a_Smoe IFPVYSFLHLLSFQTINRMITNV-KP-KDI-STLISSS--GGSDEDAKNLLNFKLLLEKI
PRP4_c_Smoe ----------------LRSMASF-NVKTSCLSDLTG--------EDGALMSRFKNLLERM
PRP4_Hsap LMLDPAKRISINQALQHAFIQE-------KI
PRP4_Mmus LMLDPAKRISINQALQHAFIQE-------KI
F22D6.5_Cele LILDPSKRTTCNEALKHPFFTI------PIK
Prp4_Ddis TILDPEKRITPFEALNHEFLK--------PF
15575_Tthe LQLDPKNRITPEEALEHPFLKLNTTNPTKPK
PRP4_Spur LMLDPSKRISINEVLRHSFIQE-------KI
CG7028_Dmel FALDPAKRISLNQALVHPFIQE-------KM
CC1G_04865_Ccin LMLDPARRITPREALSHPFIR---------G
AqueK115_Aque ------------------------------I
AqueK116_Aque FILDPTKRLSINQALQHPFIIE------KLD
PRP4_e_Smoe LTLDPSKRITPDEALKHPFLKS------VCK
PRP4_d_Smoe LTLDPSKRITPDEALKHPFLKS------VCK
PRP4_b_Smoe FILDPEKRLTVSQALNHPFIN---------K
PRP4_a_Smoe FILDPEKRLTVSQALNHPFIT---------K
PRP4_c_Smoe LTLDPSKRITPDEALKHPFLKS------VCK