8635_Tthe MQGLAQTPFDLFEPQQRLFRLPQKKSGVLKQQIFKEFIEKAQIKIKILDEENDNEVLFYT
PLK4_Hsap MAT---------------------------------------------------------
5034_Tthe MFSQEE---------------------------AKEQ-----------------------
21183_Tthe MIQQKK---------------------------DQKP-----------------------
SAK_Spur M-----------------------------------------------------------
PLK4_Mmus MAA---------------------------------------------------------
SAK_Dmel MLSNR-------------------------------------------------------
zyg-1_Cele MSGGK-------------------------------------------------------
AqueK201_Aque ------------------------------------------------------------
8635_Tthe PILFGYLSLIILKESSSTIILKHTLCYCNGKPYLIKDHQIRLLFTRCLNKINNIEKFSKY
PLK4_Hsap ------------------------------------------------------------
5034_Tthe ------------------------------------------------------------
21183_Tthe ------------------------------------------------------------
SAK_Spur ------------------------------------------------------------
PLK4_Mmus ------------------------------------------------------------
SAK_Dmel ------------------------------------------------------------
zyg-1_Cele ------------------------------------------------------------
AqueK201_Aque ------------------------------------------------------------
8635_Tthe AMNPRNGEISLKDALFFEKETFQKFNESPLLAIKPMLELYNQQIHILKQYTKLILVVLEE
PLK4_Hsap ------------------------------------------------------------
5034_Tthe ------------------------------------------------------------
21183_Tthe ------------------------------------------------------------
SAK_Spur ------------------------------------------------------------
PLK4_Mmus ------------------------------------------------------------
SAK_Dmel ------------------------------------------------------------
zyg-1_Cele ------------------------------------------------------------
AqueK201_Aque ------------------------------------------------------------
8635_Tthe LPQIFNQYSDISFLSLNQINLQLLKVKMWLIDPDTFEDQSEINEQIKRQSQIVQKKDDLK
PLK4_Hsap ------------------------------------------------------------
5034_Tthe --------------------------------------------NSDEQNQEINEQERNS
21183_Tthe ----------------------------------------------KSSSQQVEE-EENH
SAK_Spur ------------------------------------------------------------
PLK4_Mmus ------------------------------------------------------------
SAK_Dmel ------------------------------------------------------------
zyg-1_Cele ------------------------------------------------------------
AqueK201_Aque ------------------------------------------------------------
8635_Tthe ILNEI-EIIGDIQNIEQINKGGFGSIQKGKLAKILKYPLYGHFSQTMSLITKLYIMWQIA
PLK4_Hsap ---CIGEKIEDFKVGNLLGKGSFAGVYRAES-----------------------------
5034_Tthe LFNSLSAQLSDYIISHPIGSGAGSLVVKVKS-----------------------------
21183_Tthe LMNSISTSLHNFKITLTLGRGAGSCVFLIEE-----------------------------
SAK_Spur -----EDRIENYQVLNLLGRGGFACVYRAKT-----------------------------
PLK4_Mmus ---CIGERIEDFKVGNLLGKGSFAGVYRAES-----------------------------
SAK_Dmel ---AFGETIEDYEVQHLLGKGGFATVYKARC-----------------------------
zyg-1_Cele ----SGSRLSAYSHLKEIGKGGFGVVYAAQR-----------------------------
AqueK201_Aque ----------DYEVLNRLGKGSFADVYRAKC-----------------------------
:. *. . : .
8635_Tthe QGIQFLTSKNVAHLDLKPANIVISKGYLAKIIDFGEAYHPDVCNGKEFYNNQQRLIFKSY
PLK4_Hsap ------------------------------------------------------------
5034_Tthe ------------------------------------------------------------
21183_Tthe ------------------------------------------------------------
SAK_Spur ------------------------------------------------------------
PLK4_Mmus ------------------------------------------------------------
SAK_Dmel ------------------------------------------------------------
zyg-1_Cele ------------------------------------------------------------
AqueK201_Aque ------------------------------------------------------------
8635_Tthe FLMKGNPNYKPGRTLPYTPYSNNNDRQASYKNLDIFSFGMVLSEIVFDTYPVDFKRGALH
PLK4_Hsap ------------------------------------------------------------
5034_Tthe ------------------------------------------------------------
21183_Tthe ------------------------------------------------------------
SAK_Spur ------------------------------------------------------------
PLK4_Mmus ------------------------------------------------------------
SAK_Dmel ------------------------------------------------------------
zyg-1_Cele ------------------------------------------------------------
AqueK201_Aque ------------------------------------------------------------
8635_Tthe KLEEKFSRGDIRGRLVKNYQRHFGPKHIINLLHCLIFRCIDEKENRPTIDWIILISIYFK
PLK4_Hsap ------------------------------------------------------------
5034_Tthe ------------------------------------------------------------
21183_Tthe ------------------------------------------------------------
SAK_Spur ------------------------------------------------------------
PLK4_Mmus ------------------------------------------------------------
SAK_Dmel ------------------------------------------------------------
zyg-1_Cele ------------------------------------------------------------
AqueK201_Aque ------------------------------------------------------------
8635_Tthe EVNKFYQQQICKHKKTFKATKRVLTKKESTEIYFERQIKQFLYPLMIYTQVSDELSFKDI
PLK4_Hsap ------------------------------------------------------------
5034_Tthe ------------------------------------------------------------
21183_Tthe ------------------------------------------------------------
SAK_Spur ------------------------------------------------------------
PLK4_Mmus ------------------------------------------------------------
SAK_Dmel ------------------------------------------------------------
zyg-1_Cele ------------------------------------------------------------
AqueK201_Aque ------------------------------------------------------------
8635_Tthe EASLDYDIKGANGFVCKIEDFKSKECYNSNEAKKYYVYLLLTYTKQKAMKVVDKKRKDIQ
PLK4_Hsap ----------------------------------------IHTGLEVAIKMIDKKAMYKA
5034_Tthe ----------------------------------------IKTKKEYAIKVVDKQSQYYK
21183_Tthe ----------------------------------------YKSG----------------
SAK_Spur ----------------------------------------ISTGQEVAIKMIDKKLMQSS
PLK4_Mmus ----------------------------------------IHTGLEVAIKMIDKKAMYKA
SAK_Dmel ----------------------------------------LHTHQDVAIKMIDKKLIQGT
zyg-1_Cele -----------------------------------------ENGEKVAIKRIDKKVP---
AqueK201_Aque ----------------------------------------KRTKKEVAIKMIDKKLMVKK
8635_Tthe NVMKRLDQEIKIQKELDH-PNIIKLFKHFEDDQNHYLIMELAQNGEIKDYLNI-------
PLK4_Hsap GMVQRVQNEVKIHCQLKH-PSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNR------
5034_Tthe SAYKRLKNEIEIHLDLKH-KNIVKMIKSFEDSENLYLVMEYCEGGDLFHYLKH-------
21183_Tthe --------SLYLHSQLDH-PNIVKILKRFEDNEYVYMMLEYCPGGSLFDYIVYINFQLFE
SAK_Spur GMATRVKNEVEIHCQLKH-PSILELYSYFEDNNYVYLVLELAQNGELLRYLKKK------
PLK4_Mmus GMVQRVQNEVKIHCQLKH-PSVLELYNYFEDNNYVYLVLEMCHNGEMNRYLKNR------
SAK_Dmel GLTNRVRQEVEIHSRLKH-PSVLQLYTFFQDANYVYLVLELAHNGELHRYMNHI------
zyg-1_Cele --KNRVWTEIQTMKELKKSKYVVEFYEDFVEDGYTYIVMELCEGGSLQAYVREH------
AqueK201_Aque GMTERVKNEVKIHSHLKH-PSILELYDFFEDSNYVYLILEFCQNGELNRYLKHR------
.: *.: :::: * : *:::* . .*.: *:
8635_Tthe NKP----------YQLACGIKYLHDKDIVHRDLKLNNVLLS-----NGKIKIADFGLATK
PLK4_Hsap VKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLT----RNMNIKIADFGLATQ
5034_Tthe HKKLSETEAKRITYKLAEGLKYLHDKSIIHRDLKLGNVLLS----SDHQVKICDFGLAVR
21183_Tthe KTRLNEDEARDISYQIVQGLEYLHKNKIIHRDLKPGNILLT----GNNSVKICDFGLAVR
SAK_Spur ARVFGEEEARQFLEEIVIGLLYLHSHGILHRDLTLANILLT----RDMHCKIADFGLAAQ
PLK4_Mmus MKPFSEREARHFMHQIITGMLYLHSHGILHRDLTLSNILLT----RNMNIKIADFGLATQ
SAK_Dmel ARPFTETEAASILKQVVAGLLYLHSHNIMHRDISLSNLLLS----REMHVKIADFGLATQ
zyg-1_Cele G-ALDDATAVHVLRQLISAVSFMHRVNVIHRDLSAGNVFIKDSKKKKMTVKLGDFGLATT
AqueK201_Aque QKSLSEDE-RIILNQVVKGLIYLHSFNIVHRDLSLSNILLT----SSMDIKIADFGLSVT
:: .: ::* ::***:. *:::. . *: ****:.
8635_Tthe VNDENPECNTMCGTANYLSP-----------------EILNSKGYGKKTDIWSFGCILYA
PLK4_Hsap LKMPHEKHYTLCGTPNYISP-----------------EIATRSAHGLESDVWSLGCMFYT
5034_Tthe LNGNEQEKNTICGTPNYISP-----------------EILNKQPYGMKIDCWSFGCILYA
21183_Tthe VTNYESERDTFCGTPNYIAP-----------------E-----KYGIQSDCWSFGCILYT
SAK_Spur LKLPEEQHYTMCGTPNYISP-----------------EIATRGPHGLQSDVWSLGCMLYT
PLK4_Mmus LNMPHEKHYTLCGTPNYISP-----------------EIATRSAHGLESDIWSLGCMFYT
SAK_Dmel LKRPDERHMTMCGTPNYISP-----------------EVVSRTSHGLPADVWSVGCMLYT
zyg-1_Cele LGRG-ETTCTIVGTPGFIAP-----------------QVYDQ-EYTQSADVYSLGAVLYT
AqueK201_Aque LDLPGDKHHTLCGTPNYIAPYVICCYEGCFLIFIFCREVAKREAHGLESDIWSLGCMVYT
: *: **..:::* : : * :*.*.:.*:
8635_Tthe LCSGNLPFFSGNPSQTIQNIKEGK--WQLPQNISDNVKDLLSNTLNWDQNSRFSIEQVLS
PLK4_Hsap LLIGRPPFDTDTVKNTLNKVVLAD--YEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLD
5034_Tthe LIVGHPPFQGQDIVQTLKKVTSQEQFFELPNNISDNLKDLLVNIINWNQDSRFTIDQILM
21183_Tthe IATGRPPFETVSIQQTLKMLQKKN-KVEYPSHLSKSLVDLIDHILDWNQDTRYNISQIKS
SAK_Spur FLTGTPPFDTEAVKTTLNKVMLAE--YIIPTHISMEAKDLINKMLRKDPTERIGLSTVLD
PLK4_Mmus LLIGRPPFDTDTVKNTLNKVVLAD--YEMPAFLSREAQDLIHQLLRRNPADRLSLSSVLD
SAK_Dmel LLVGRPPFETDAVQSTLNKVVMSE--YIMPAHLSYEAQDLINKLLKKLPHERITLEAVLC
zyg-1_Cele MLTARNPPPKGLP-P--------------TCGMSPNAARLVEQMMDTDAKKRIPLTQIVL
AqueK201_Aque MLVGTPPFDTDDVQSTLDNVVNGD--FDIPQYITTNCTSLNL--HVYHPSKRLTLQQVLY
: . * . :: . * * : :
8635_Tthe HKFYEKKHKQSIIIFN-----------------------------QGADAISNQ-----Q
PLK4_Hsap HPFMSRNSSTKSKDLG-----------------------------TVEDSIDSG-----H
5034_Tthe HPFYEEMRQKSVKQRQ-----------------------------EEEESLSFF-----N
21183_Tthe HPFYNKSKQNTHENEY-----------------------------KLQNPMTFAPPQPFQ
SAK_Spur HPFMDKTRFNGTKNRP-LS---------------------K---RPVESSLDSG-----L
PLK4_Mmus HPFMSRNPSPKSKDVG-----------------------------TVEDSMDSG-----H
SAK_Dmel HPFMLKCSNGGHSAPG--A---------------------L---NVFSQSMESG-----D
zyg-1_Cele SEFMYENTNENAVIFS--------------------------------------------
AqueK201_Aque HSFTKGVQQENVLQKRTLSLTTPVIATYRGDCQFHGSRVLKNIQLEAPASVDSG-----N
*
8635_Tthe NKLSTP-------------NKVLL-------------DWTSP-RFNAPIHLQQKSQSSQK
PLK4_Hsap A-----------------------TISTAIT-----------AS--SS------------
5034_Tthe SIRSVKGEDQRINVHQNGVKKIDIKYQDNFFNQLEHKEGSMPKKSNSPTNIHERKNQMIY
21183_Tthe MEQSV-------NQNNKNIQQGHTRQRSNFS-----------MD--SS------------
SAK_Spur A-----------------------TMATISS-----------SH--TS------------
PLK4_Mmus A-----------------------TLSTTIT-----------AS--SG------------
SAK_Dmel S-----------------------GIITFAS-----------SD--SR------------
zyg-1_Cele ------------------------------R-----------EH--SR------------
AqueK201_Aque V-----------------------TLATNYS-----------GP--TS------------
:
8635_Tthe KNKRISNLKNQKS----LTSMKLDLSDCNKENQPNLINSSNNKSNNTAIIEKQKSTKSNT
PLK4_Hsap ------------------TSISG-------------------------------------
5034_Tthe KNDQIAALKNNKIQNEDL-------------NIMS--NNLNQIQYKKQSQNN--LVKQND
21183_Tthe --NNSKHFQQNKIMNDNL-------------YQINNINRSNQIQENNVLQNK--QTKENR
SAK_Spur ------------------NRTSS-------------------------------------
PLK4_Mmus ------------------TSLSG-------------------------------------
SAK_Dmel ------------------NSQQI-------------------------------------
zyg-1_Cele ------------------DG----------------------------------------
AqueK201_Aque ------------------R-YST-------------------------------------
8635_Tthe YKEQQ--NIQSNQQNSLGMSNIFLTTARSINLADNSIIMSTLQDNQLNNTNNK-KENTKP
PLK4_Hsap ----------------------------------------------SLFDKRR-LLIGQP
5034_Tthe KQILNQKEINFARKNS------------------PVDRFDVENQQNNMNKQKDDASHTVK
21183_Tthe FQSKEQLLVNENKENI------------------HSNILNSINNQQKLFQQQQ-KLNPIP
SAK_Spur --------------------------------------------------RSR-PMRALP
PLK4_Mmus ----------------------------------------------SLLD-RR-LLVGQP
SAK_Dmel ----------------------------------------------RSVENSG-PQQVL-
zyg-1_Cele ------------------------------------------------------------
AqueK201_Aque --------------------------------------------------RRG-------
8635_Tthe TQKLQYYLQQNSNTSQQLKQSS--------------------------------------
PLK4_Hsap LPNKMTVFPKNKSSTDFSSS-GDGNSFYTQWGN---------------------------
5034_Tthe VKEIHSHNQQLNIRKQSPTNQILNYDK------DKIAIPERKSLTQQSQAINQNDVFKSP
21183_Tthe LQKSYSYNQKNEQKQDQILHQTLAQGLKKEVSEQSIDNNRNKQIIQEIQNISQNSYY---
SAK_Spur LSTLTPVISEGEGSRGQVKGHHHGDGIGSSWNQ---------------------------
PLK4_Mmus LPNKITVFQKNKNSSDFS-S-GDGSNFCTQWGN---------------------------
SAK_Dmel ------------------------------------------------------------
zyg-1_Cele ------------------------------------------------------------
AqueK201_Aque -PVKATFFPSS-------------------------------------------------
8635_Tthe ------------------------------------------------------------
PLK4_Hsap --------------------------QETSNSGRGRVIQDA-------------EERP--
5034_Tthe KLTSNQQEIKQTFINNIEKIKSNQPPVPQNQQQQNNSAITT-------------YGGQ--
21183_Tthe -----------------------NPQISQSNKQQQQQIDTI-------------QQKP--
SAK_Spur --------------------YD-R--HPPSPPVRQRANHSAALQSRSEQAGETLESRPWF
PLK4_Mmus --------------------PE----QEANSRGRGRVIEDA-------------EERP--
SAK_Dmel --------------------------------------PQI-------------REEF--
zyg-1_Cele ------------------------------------------------------------
AqueK201_Aque --------------------------------G-SHLQEDQS------------RKAT--
8635_Tthe -------------------------------------------ILNNQGQASGYNNSRNR
PLK4_Hsap ---------HSRYLRRAYSSDRSGT-------------------SNSQSQAKTYTME---
5034_Tthe ---------EKRGVKSIVY-NNSNNQNNINTNQNSNQYNIQNSITNNQINPTNNYKTVNS
21183_Tthe ---------QSKTILNTFL-NKATKSNSLHQS--------------SSTTPSSNQQNINT
SAK_Spur SGAALKQKASSSQDLRMTSSDRMQPH-----------------VSSHTSQTRDYNLT-AK
PLK4_Mmus ---------HSRYLRRAHSSDRASP-------------------SN-QSRAKTYSVE---
SAK_Dmel ---------KQVHHKLPY------------------------------------------
zyg-1_Cele --------------RRQRSREPVRS-------------------SR-DDRSRDG------
AqueK201_Aque ---------SGLHHRRAHSLE---------------------------------------
8635_Tthe FDLSCNNVINQNKSQQSLLQYNGYKSQSVIPQQQQAFSQNSQQISNKNQPQQQNTKELT-
PLK4_Hsap -----------------------RCHSAEML----------SVSKRSG-----GGENEER
5034_Tthe SNINNNYYSNTSQSQQF---INGINHQHDIHSRTAANSNHDKYIKNTN-----NIRNNS-
21183_Tthe NNFFQSQKSYKNPIVQI---LNGF------------------------------------
SAK_Spur PSINDGSMKGFD-TKTR---GMYQSHEQDIHRSQGHVYHDDAQVKRSG-----SWKSQEF
PLK4_Mmus -----------------------RCHSVEML----------SKPRRS-------------
SAK_Dmel -------------------------------EQTG-LFGQA-------------------
zyg-1_Cele ----------------R---ALIRSSSQPAH-----------------------------
AqueK201_Aque ------------------------------------------------------------
8635_Tthe --PKQFNPYL---SQN--------------------------------------------
PLK4_Hsap YSPTDNNANIFNFFKEKT-SSSSGSFER---PDN----NQALSNHLCPGKT---PF---P
5034_Tthe --PVNNNSYI---ERNQSPNTQNNHMSSSSVLNNGQQQSQHKNNSYSISQSKVIPL----
21183_Tthe ----PNDSKI---QQNQAINHQKNK---------------------SLDISGIIP-----
SAK_Spur ---LGQHGSV---LREKSRTETSGHYDR---VDD----AK--------------------
PLK4_Mmus -------------------------------LDE----NQHSSNHHCLGKT---PF---P
SAK_Dmel -------ST-------------------------------GLAE----------------
zyg-1_Cele -----------------------------------------------SGRA---PLSNRP
AqueK201_Aque ------------------------------------------------------------
8635_Tthe -------SEKTQQDYSN--NAFKSYRSTSSLHQNISIANT-SQTYRNPLQESQINKNNQQ
PLK4_Hsap FADPTPQTETVQQWFGN--LQINAHLRKTTEYDSISPNRD-FQGHPDLQKDTSKNAWTDT
5034_Tthe -------PKKVQTSFLQNLNSLTDVDRFSPPHNNTNSTNTTTNNYVN-IQ-SEINNFPQP
21183_Tthe ---------------------------------------------------------PQP
SAK_Spur -------------------------HRLFSEADIDSDRR---QDLT-VRTDHAKDKCTDK
PLK4_Mmus FADQTPQMEMVQQWFGN--LQMNAHLGETNEHHTVSPNRD-FQDYPDLQ-DTLRNAWTDT
SAK_Dmel -----------PNWPGA--AKSS-------------------------------------
zyg-1_Cele IHDRMPS-----------------------------------------------------
AqueK201_Aque ------------------------------------------------------------
8635_Tthe RQEAFDNTKQALHNVK-------K--PLQYFSQQQ----QTQKD--GDNQMFTQSQNN--
PLK4_Hsap KVKKNSDASDNAHSVK-------QQNTMKYMTALH----SK--PEIIQQEC------VFG
5034_Tthe QTVSHNRTKNQVSFEN-------K--PIQAQVQNQ----TTQKVMQSSDQGFYKKNNNPP
21183_Tthe PR-PRDEQKNQLSFKTIDQENIQK--KQISIDQSNQNEFVTTPS--GNNKMFSQSSNN--
SAK_Spur KQSAQSSVSDHP-SVH-------GMHAAVPSSASC-----G--GLSSKQDGALHKDSKAG
PLK4_Mmus RASKNADTSANVHAVK-------QLSAMKYMSAHH----HK--PEVMPQE--------PG
SAK_Dmel ---------------------------------------------------AFCME--AG
zyg-1_Cele -------------------------------TSSR--------GFDSERGRERDRDSGRG
AqueK201_Aque ------------------------------------------------------------
8635_Tthe ----------NTNKQMKGDNTLNG------------------------NLKYSSL-STNS
PLK4_Hsap SDPLSEQSKTRGMEPP-------W--------------------------------GYQN
5034_Tthe QSVQTNLQRNQSPQLHVGNKNTSD------------------------NLNYYLTKKDHP
21183_Tthe ----------MIFMKENNNSKIQN------------------------VKKKMSL-----
SAK_Spur ERSSHRRSKSKSHDLD-------KGSEWTHRHTRKHEKREGGGGGGKGEG------GAGV
PLK4_Mmus LHPHSEQSKNRSMEST-------L--------------------------------GYQK
SAK_Dmel NVPNSKQASLK-------------------------------------------------
zyg-1_Cele TVPPSREDRN--------------------------------------------------
AqueK201_Aque ------------------------------------------------------------
8635_Tthe QTLN--------------------------KNDESYIHNYHQ------------------
PLK4_Hsap RTLRSITSPLVAHRLKPIRQKTKKAVVSILDSEEVCVELVKE-----YASQ----EYVKE
5034_Tthe QCVE--------------------------DQADKYEEIIHQ-----RKNENKIINRENN
21183_Tthe ------------------------------------------------------------
SAK_Spur QSLAHLTPPLNATRLRPIRQRTRNAVVSIMLGGEVCLEFLKT-----KDGQ----DRVVE
PLK4_Mmus PTLRSITSPLIAHRLKPIRQKTKKAVVSILDSEEVCVELLRE-----CASE----GYVKE
SAK_Dmel -EDRISVPPLNTKRLLPTRYKTKNAIMSILRNGEVVLEFLKF---RPTYNE----DRIND
zyg-1_Cele ---RSQLWPIRMDRLEGQRVCT--------AGGRYIVELDTRCRFEVAAQG----NFVKR
AqueK201_Aque -----------------------------------------------------------D
8635_Tthe -PRIRSQQSQQNVNLREK---S-PSCQF-IQKNQEISSQNNCDGIKDLQNINKI-----Q
PLK4_Hsap VLQISSDGN--TITIYYP---N-GGRGF-PLADR-PPSPT--------------------
5034_Tthe IKRISSEQNISRVSTEYK---N-GSNDF-NTQNK-LNNQYNNNKINIDYTSNQLM--NNN
21183_Tthe -----------HFPTEQT---N-ISQDIISTNTT-CRNNITTTMTFPSPSSQQFLAQNNN
SAK_Spur VLRISQDGM--QVTIYQP---N-GGKGF-PIMEH-PPSPP--------------------
PLK4_Mmus VLQISSDGT--MITVYYP---N-DGRGF-PLADR-PPLPT--------------------
SAK_Dmel ICRISDDGQ--RIIIYQP---D-PGRGL-PVREQ-PPDLQ--------------------
zyg-1_Cele ILIVEVDEM--VQTVYVHRIPDRTVRGR-NGEEE-LITLT--------------------
AqueK201_Aque VCRGNDEIM---------------------------------------------------
8635_Tthe QNSQIKRNYSQQITPKEMQTNSNIQ---KLEYA----------------NRISQLCAKGD
PLK4_Hsap ------------------------------------------------------------
5034_Tthe QQYKINQEYNQNKLSNDFSSNNNKMNNNYVSNKINTEYNTNKMINHDNPNRMSNEINKSN
21183_Tthe NQIIINQNIQRQKPSKSTHNN----DNNHTSFDIS-------------------------
SAK_Spur ------------------------------------------------------------
PLK4_Mmus ------------------------------------------------------------
SAK_Dmel ------------------------------------------------------------
zyg-1_Cele ------------------------------------------------------------
AqueK201_Aque ------------------------------------------------------------
8635_Tthe HNFLLEKKSSSNSNNNCQQ--------------NVQSSKNIRSLSNSQF-----------
PLK4_Hsap ------------------------------------------------------------
5034_Tthe VDHYSNKNNSDFNKINVDYNSNKINYDPNKANIDYSSNNKINIEFNSNNKINNGYVSNKV
21183_Tthe ---YLKLDSSQMNSFSVER--------------DFQSTAQFSSKSNVIHTPTNVSISQKP
SAK_Spur -----------------------------------------------------------Q
PLK4_Mmus ------------------------------------------------------------
SAK_Dmel -----------------------------------------------------------I
zyg-1_Cele ------------------------------------------------------------
AqueK201_Aque ------------------------------------------------------------
8635_Tthe ----------------------------TINSNIKQ------------------------
PLK4_Hsap -DNIS-RYSFDN-LPEK-------YWRKYQYASRF--VQLV-------------------
5034_Tthe TSEVN-KYNYES-NHNKYGNEQNQYKIKYEFSSPK--MNTEQNTSRLNTDYKGTRLNTDF
21183_Tthe PSNKN-SYTYRDINPPSFAPSQQPTSLMRAKGSSKEYIKTEPCDIDVNQTPRLECLETE-
SAK_Spur DSGIT-KHSYHD-LPSK-------YWKKYQYASRF--IQLV-------------------
PLK4_Mmus -DNIS-RYSFDN-LPEK-------YWRKYQYASRF--IQLV-------------------
SAK_Dmel PSGDC-VYNYDN-LPSK-------HWKKYIYGARF--VGLV-------------------
zyg-1_Cele -NNPFVYTSYSQ-MPKE-------VQNDYMRLQKM--VAVT-------------------
AqueK201_Aque ------------------------------------------------------------
8635_Tthe ------------------------------------------------------------
PLK4_Hsap ---------------------------------RSKSPKITYFT----RYAKC-ILMENS
5034_Tthe NNTRDNTECNTQRLNTEQNTARLTTEQYNPQRVISKNKAIMF----SMDNLQGKLNMENA
21183_Tthe ------------------------------------------------------------
SAK_Spur ---------------------------------RSKTPKVTLYT----PHAKC-MLMENG
PLK4_Mmus ---------------------------------RSKTPKITYFT----RYAKC-ILMENS
SAK_Dmel ---------------------------------KSKTPKVTYFS----TLGKC-QLMETM
zyg-1_Cele --------------------------------ISGRVAKVTFRRPSQFPDAQA-QLMENG
AqueK201_Aque ------------------------------------------------------------
8635_Tthe -------------------KIQKDTSELS----------------IQVTDRQ--------
PLK4_Hsap PGADFEVWFY------DGVKIHKTE-D-F----------------IQVIEKTG-------
5034_Tthe NN---RISVEQNINGRFNNEIMKTNNENLILKNGNAQNILNTNAHPKIIDKKQKSEVPLI
21183_Tthe ------------------------------------------------------------
SAK_Spur PTADCEACFY------DGTKIHATS-V-E----------------LEVTESNG-------
PLK4_Mmus PGADFEVWFY------DGAKIHKTE-N-L----------------IHIIEKTG-------
SAK_Dmel --TDFEIRFY------SGAKLLKTPSE-G----------------LKVYDRNG-------
zyg-1_Cele ---DLRIKLP------RSVIVRKMD-N-------------------------G-------
AqueK201_Aque ------------------------------------------------------------
8635_Tthe --------------ITFQGNEQNEKINFTK-----------------------SPTQIQT
PLK4_Hsap -------------------------------------------------------KSYTL
5034_Tthe SQIANQPMRSSQVQLTQQQQQQNIPITFLNEDRDLYKKQEKFDKVKHFKNQTSDNANYSL
21183_Tthe ---------------------NNENT------------------------STAACSKYSM
SAK_Spur -------------------------------------------------------QTCKL
PLK4_Mmus -------------------------------------------------------ISYNL
SAK_Dmel -------------------------------------------------------MLLSD
zyg-1_Cele -------------------------------------------------------EIFNC
AqueK201_Aque ------------------------------------------------------------
8635_Tthe RNNSKSFSQSVNCAPIASSKERKVSFV-AQSA-DLQEQ----------------------
PLK4_Hsap KSESEVNSLKEE---------IKMYMDHANEGHRICLALESIISEEERKTRSAPFFPIII
5034_Tthe NNTNNINGSNEY---------NKEFFN-AQYQQQLQDQQEKMMNSKVNTYRNSQIFESQV
21183_Tthe NTTNRSFNKGLN---------TSKSFS-SFIA-DQTNEIDKYSNNIQLNQQNSNIITSQI
SAK_Spur PADQNNDQIPSH---------LKPIISSFYTWRQHCVDVESAIASLESRHGYGPFFPLIL
PLK4_Mmus KNENEVTSLKEE---------VKVYMDHANEGHRICLSLESVISEEEKRSRGSSFFPIIV
SAK_Dmel YSCSES----------------RSLIEHGNECFTHCVNISNALEVA--QTKDNSCFPVTI
zyg-1_Cele ID--GIATQKQAV--------SGITLTKVNEVYKYLIRFEQCLNGM---DRGMVCFPIVF
AqueK201_Aque -------------------------------------KLS-------------NCF----
8635_Tthe ----I-QII---------------------------------------------------
PLK4_Hsap GRKPG-STS---------------------------------------------------
5034_Tthe GTQRV-QAV---------------------------------------------------
21183_Tthe SPVKV-------------------------------------------------------
SAK_Spur SRKPL-QESYQQGNKLPASTN-IRTSAVTSHTTPATTTTTSTTTVPPSTTPHPSGPTQAC
PLK4_Mmus GRKPG-NTS---------------------------------------------------
SAK_Dmel GRRPI-TDV---------------------------------------------------
zyg-1_Cele SAGTNMVGS---------------------------------------------------
AqueK201_Aque SGE--------QSVSFSLKDNDVPSSSVYSQRDPVTC-----------------------
8635_Tthe ------QSKSTQQTG---------------------------------------------
PLK4_Hsap ------SPKALSPPPS--------------------------------------------
5034_Tthe ------KSKSRIQSGL--------------------------------------------
21183_Tthe --------------GD--------------------------------------------
SAK_Spur PQGSVTSPSVMAAPTASVCSFDGTICSVARSVQGKDRTRHRKIDKGGSSKEASKVTSQAS
PLK4_Mmus ------SPKALSAPPV--------------------------------------------
SAK_Dmel ------QPAQRL-DGL--------------------------------------------
zyg-1_Cele ------SPSSLMPSGS--------------------------------------------
AqueK201_Aque ------------------------------------------------------------
8635_Tthe ------------------------------------------------------------
PLK4_Hsap ------------------------------------------------------------
5034_Tthe ------------------------------------------------------------
21183_Tthe ------------------------------------------------------------
SAK_Spur SHPEGKDGVLKSVFVPNIGWASQMSSGEVRVQYNDGSMILVHAATSTIKYMDSQGKGQRA
PLK4_Mmus ------------------------------------------------------------
SAK_Dmel ------------------------------------------------------------
zyg-1_Cele ------------------------------------------------------------
AqueK201_Aque ------------------------------------------------------------
8635_Tthe ----------------------------------------------------------AV
PLK4_Hsap ----------------------------------------VDS-NYPTRERASFNRMVMH
5034_Tthe ----------------------------------------------------------KT
21183_Tthe ----------------------------------------------------------DL
SAK_Spur QWKKWIRWRQHCVDVESAIASLESRHGYGPFFPLILSRKPLQE-SYQQGNKVTASKNIRT
PLK4_Mmus -----------------------------------------DP-SCCKGEQASASRLSVN
SAK_Dmel ----------------------------------------RDTTNIAF------------
zyg-1_Cele ----------------------------------------SQTSRF------PFSNLSNN
AqueK201_Aque ------------------------------------------------------------
8635_Tthe NFA-DSKTQYQSNDTNSSFPVSPLSTQGLKANK------------VNTKNGIIE-----I
PLK4_Hsap SAA-SPTQAPI---------LNPSMV-----TNEG---------------------LGLT
5034_Tthe DVS-DSETNSISNQNSTTNNLEYYE-----SPR------------INTLNLMLSPERRIP
21183_Tthe DVS-----------------------------K------------IKTKNGYIE-----I
SAK_Spur SAA-TSHTTPATTATS-TNTVPPSTT-----PHPGGPTQACPQGSVTSPS------VMAA
PLK4_Mmus SAA-FPTQSPG---------LSPSTV-----TVEG---------------------LGHT
SAK_Dmel -------STPKSNQGS----INFSLS-----TI--------------------------S
zyg-1_Cele QPSLVPHSAPF---------LTKPT----------------------------------S
AqueK201_Aque ------------------------------------------------------------
8635_Tthe SEN------------------------NWLSIECQNGQL---------------------
PLK4_Hsap TTA------------------------SGTDI------------SSN--------SLKDC
5034_Tthe TTN------------------------NSTAVKN-NSQMKNLLSGNKDNSSCKNNSNNTS
21183_Tthe TSD------------------------HSLLVESCNGRL---------------------
SAK_Spur PTASVCSFDGTICSVARSVQGKDRTRHRKTDK------------GGSSKEACKVTSQASS
PLK4_Mmus ATA------------------------TGTGV------------SS-------------S
SAK_Dmel STR------------------------NTSDF------------GTN--------CSRSN
zyg-1_Cele SQR------------------------AS---------------SAN--------V-QRR
AqueK201_Aque --------------ISR-------------------------------------------
8635_Tthe IFKISPNGEQV---------------------------------------------VCQT
PLK4_Hsap ---LPKSA-Q-------------------------------------LLKSVFVKNVGWA
5034_Tthe RKNTSKQNNNLKWNDRNNRRKRIHSSVNLKKHNDGDFSRWQRCHVDKVRRAFKQKTLQKN
21183_Tthe LFKISKDGQKIQINKLIDKPMEKHYTLNN----LPAKYYALYGY---------AKQVINA
SAK_Spur ---HPEGKDG-------------------------------------VLKSVFVPNIGWA
PLK4_Mmus ---LPKSA-Q-------------------------------------LLKSVFVKNVGWA
SAK_Dmel ---MLAAHQN------------------------------------IPIKRINVPEIGIA
zyg-1_Cele ---VSTDEN--------------------------------------SSPSVAPSKYKIK
AqueK201_Aque ------------------------------------------------------------
8635_Tthe LKS-KTPLVKIQNEKGTFMLMSNQPKQNYEVSLSNGYKVSHVIGTDIMTVKDKQNKEFIV
PLK4_Hsap TQL-TSGAVWVQFNDGSQLVVQAG-----------------------------VS--SIS
5034_Tthe AQD-KSAKVKLENEDGQFYLYENK----FEGVFSNGFIVNYKLNSQNLEIQTNKYAPKIV
21183_Tthe LKT-KKVISKLENKEGIFILLENN---CFEAQFKTGYKIYYKNKNASMKIKAPDNNIYEI
SAK_Spur SQM-SSGEVRVQYNDGSMILVHAT-----------------------------TS--TIK
PLK4_Mmus TQL-TSGAVWVQFNDGSQLVVQAG-----------------------------VS--SIS
SAK_Dmel TEL-SHGVVQVQFYDGSVVSVIPS---------------------------MQGG--GIT
zyg-1_Cele IDPTTQKVRSIQATDGRVLRCST----------------------------SKAD--QFI
AqueK201_Aque ------------------------------------------------------------
8635_Tthe YLSQQ--NL------NKSIPQEITLAVKVSLEQMSSCLQKQ-------------------
PLK4_Hsap YTSPNG--QTTRYGENEKLPDYI---K-QKLQCLSSILLMF-------------------
5034_Tthe F-DLQ--KD------LKHASKEMKTIVQ-KTQKIISII----------------------
21183_Tthe --SLE--KN------SKDFPQEVKNITS-KSLKYYEYLLN--------------------
SAK_Spur YMDSQG--KGQSYGRNAVLPSHI---R-EKLLHMPHIIQLF-------------------
PLK4_Mmus YTSPDG--QTTRYGENEKLPEYI---K-QKLQCLSSILLMF-------------------
SAK_Dmel YTQPNG--TSTHFGKGDDLPFPV---R-DRVGQIPNIQLKLKTAPLLGSGRKTDYNNAMT
zyg-1_Cele FTDPAIRPDDQRFMRTDRVPDRA---S-EMLHTLCER-----------------------
AqueK201_Aque ---------------NSSLDSSV---S-ERRTT---------------------------
8635_Tthe ----NEQYLANFK
PLK4_Hsap -----SNPTPNFH
5034_Tthe --------TSMKS
21183_Tthe -----QNKEFQNI
SAK_Spur -----VN-QNKPT
PLK4_Mmus -----SNPTPNFQ
SAK_Dmel PKTTTPYYNRMLL
zyg-1_Cele -------MRKLHQ
AqueK201_Aque ---ANSTMVSKCI