Protein (view, download) , Domain (view, download)
8635_Tthe       MQGLAQTPFDLFEPQQRLFRLPQKKSGVLKQQIFKEFIEKAQIKIKILDEENDNEVLFYT
PLK4_Hsap       MAT---------------------------------------------------------
5034_Tthe       MFSQEE---------------------------AKEQ-----------------------
21183_Tthe      MIQQKK---------------------------DQKP-----------------------
SAK_Spur        M-----------------------------------------------------------
PLK4_Mmus       MAA---------------------------------------------------------
SAK_Dmel        MLSNR-------------------------------------------------------
zyg-1_Cele      MSGGK-------------------------------------------------------
AqueK201_Aque   ------------------------------------------------------------


8635_Tthe       PILFGYLSLIILKESSSTIILKHTLCYCNGKPYLIKDHQIRLLFTRCLNKINNIEKFSKY
PLK4_Hsap       ------------------------------------------------------------
5034_Tthe       ------------------------------------------------------------
21183_Tthe      ------------------------------------------------------------
SAK_Spur        ------------------------------------------------------------
PLK4_Mmus       ------------------------------------------------------------
SAK_Dmel        ------------------------------------------------------------
zyg-1_Cele      ------------------------------------------------------------
AqueK201_Aque   ------------------------------------------------------------


8635_Tthe       AMNPRNGEISLKDALFFEKETFQKFNESPLLAIKPMLELYNQQIHILKQYTKLILVVLEE
PLK4_Hsap       ------------------------------------------------------------
5034_Tthe       ------------------------------------------------------------
21183_Tthe      ------------------------------------------------------------
SAK_Spur        ------------------------------------------------------------
PLK4_Mmus       ------------------------------------------------------------
SAK_Dmel        ------------------------------------------------------------
zyg-1_Cele      ------------------------------------------------------------
AqueK201_Aque   ------------------------------------------------------------


8635_Tthe       LPQIFNQYSDISFLSLNQINLQLLKVKMWLIDPDTFEDQSEINEQIKRQSQIVQKKDDLK
PLK4_Hsap       ------------------------------------------------------------
5034_Tthe       --------------------------------------------NSDEQNQEINEQERNS
21183_Tthe      ----------------------------------------------KSSSQQVEE-EENH
SAK_Spur        ------------------------------------------------------------
PLK4_Mmus       ------------------------------------------------------------
SAK_Dmel        ------------------------------------------------------------
zyg-1_Cele      ------------------------------------------------------------
AqueK201_Aque   ------------------------------------------------------------


8635_Tthe       ILNEI-EIIGDIQNIEQINKGGFGSIQKGKLAKILKYPLYGHFSQTMSLITKLYIMWQIA
PLK4_Hsap       ---CIGEKIEDFKVGNLLGKGSFAGVYRAES-----------------------------
5034_Tthe       LFNSLSAQLSDYIISHPIGSGAGSLVVKVKS-----------------------------
21183_Tthe      LMNSISTSLHNFKITLTLGRGAGSCVFLIEE-----------------------------
SAK_Spur        -----EDRIENYQVLNLLGRGGFACVYRAKT-----------------------------
PLK4_Mmus       ---CIGERIEDFKVGNLLGKGSFAGVYRAES-----------------------------
SAK_Dmel        ---AFGETIEDYEVQHLLGKGGFATVYKARC-----------------------------
zyg-1_Cele      ----SGSRLSAYSHLKEIGKGGFGVVYAAQR-----------------------------
AqueK201_Aque   ----------DYEVLNRLGKGSFADVYRAKC-----------------------------
                                 :. *. . :   .

8635_Tthe       QGIQFLTSKNVAHLDLKPANIVISKGYLAKIIDFGEAYHPDVCNGKEFYNNQQRLIFKSY
PLK4_Hsap       ------------------------------------------------------------
5034_Tthe       ------------------------------------------------------------
21183_Tthe      ------------------------------------------------------------
SAK_Spur        ------------------------------------------------------------
PLK4_Mmus       ------------------------------------------------------------
SAK_Dmel        ------------------------------------------------------------
zyg-1_Cele      ------------------------------------------------------------
AqueK201_Aque   ------------------------------------------------------------


8635_Tthe       FLMKGNPNYKPGRTLPYTPYSNNNDRQASYKNLDIFSFGMVLSEIVFDTYPVDFKRGALH
PLK4_Hsap       ------------------------------------------------------------
5034_Tthe       ------------------------------------------------------------
21183_Tthe      ------------------------------------------------------------
SAK_Spur        ------------------------------------------------------------
PLK4_Mmus       ------------------------------------------------------------
SAK_Dmel        ------------------------------------------------------------
zyg-1_Cele      ------------------------------------------------------------
AqueK201_Aque   ------------------------------------------------------------


8635_Tthe       KLEEKFSRGDIRGRLVKNYQRHFGPKHIINLLHCLIFRCIDEKENRPTIDWIILISIYFK
PLK4_Hsap       ------------------------------------------------------------
5034_Tthe       ------------------------------------------------------------
21183_Tthe      ------------------------------------------------------------
SAK_Spur        ------------------------------------------------------------
PLK4_Mmus       ------------------------------------------------------------
SAK_Dmel        ------------------------------------------------------------
zyg-1_Cele      ------------------------------------------------------------
AqueK201_Aque   ------------------------------------------------------------


8635_Tthe       EVNKFYQQQICKHKKTFKATKRVLTKKESTEIYFERQIKQFLYPLMIYTQVSDELSFKDI
PLK4_Hsap       ------------------------------------------------------------
5034_Tthe       ------------------------------------------------------------
21183_Tthe      ------------------------------------------------------------
SAK_Spur        ------------------------------------------------------------
PLK4_Mmus       ------------------------------------------------------------
SAK_Dmel        ------------------------------------------------------------
zyg-1_Cele      ------------------------------------------------------------
AqueK201_Aque   ------------------------------------------------------------


8635_Tthe       EASLDYDIKGANGFVCKIEDFKSKECYNSNEAKKYYVYLLLTYTKQKAMKVVDKKRKDIQ
PLK4_Hsap       ----------------------------------------IHTGLEVAIKMIDKKAMYKA
5034_Tthe       ----------------------------------------IKTKKEYAIKVVDKQSQYYK
21183_Tthe      ----------------------------------------YKSG----------------
SAK_Spur        ----------------------------------------ISTGQEVAIKMIDKKLMQSS
PLK4_Mmus       ----------------------------------------IHTGLEVAIKMIDKKAMYKA
SAK_Dmel        ----------------------------------------LHTHQDVAIKMIDKKLIQGT
zyg-1_Cele      -----------------------------------------ENGEKVAIKRIDKKVP---
AqueK201_Aque   ----------------------------------------KRTKKEVAIKMIDKKLMVKK


8635_Tthe       NVMKRLDQEIKIQKELDH-PNIIKLFKHFEDDQNHYLIMELAQNGEIKDYLNI-------
PLK4_Hsap       GMVQRVQNEVKIHCQLKH-PSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNR------
5034_Tthe       SAYKRLKNEIEIHLDLKH-KNIVKMIKSFEDSENLYLVMEYCEGGDLFHYLKH-------
21183_Tthe      --------SLYLHSQLDH-PNIVKILKRFEDNEYVYMMLEYCPGGSLFDYIVYINFQLFE
SAK_Spur        GMATRVKNEVEIHCQLKH-PSILELYSYFEDNNYVYLVLELAQNGELLRYLKKK------
PLK4_Mmus       GMVQRVQNEVKIHCQLKH-PSVLELYNYFEDNNYVYLVLEMCHNGEMNRYLKNR------
SAK_Dmel        GLTNRVRQEVEIHSRLKH-PSVLQLYTFFQDANYVYLVLELAHNGELHRYMNHI------
zyg-1_Cele      --KNRVWTEIQTMKELKKSKYVVEFYEDFVEDGYTYIVMELCEGGSLQAYVREH------
AqueK201_Aque   GMTERVKNEVKIHSHLKH-PSILELYDFFEDSNYVYLILEFCQNGELNRYLKHR------
                        .:     *.:   ::::   * :    *:::* . .*.:  *:

8635_Tthe       NKP----------YQLACGIKYLHDKDIVHRDLKLNNVLLS-----NGKIKIADFGLATK
PLK4_Hsap       VKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLT----RNMNIKIADFGLATQ
5034_Tthe       HKKLSETEAKRITYKLAEGLKYLHDKSIIHRDLKLGNVLLS----SDHQVKICDFGLAVR
21183_Tthe      KTRLNEDEARDISYQIVQGLEYLHKNKIIHRDLKPGNILLT----GNNSVKICDFGLAVR
SAK_Spur        ARVFGEEEARQFLEEIVIGLLYLHSHGILHRDLTLANILLT----RDMHCKIADFGLAAQ
PLK4_Mmus       MKPFSEREARHFMHQIITGMLYLHSHGILHRDLTLSNILLT----RNMNIKIADFGLATQ
SAK_Dmel        ARPFTETEAASILKQVVAGLLYLHSHNIMHRDISLSNLLLS----REMHVKIADFGLATQ
zyg-1_Cele      G-ALDDATAVHVLRQLISAVSFMHRVNVIHRDLSAGNVFIKDSKKKKMTVKLGDFGLATT
AqueK201_Aque   QKSLSEDE-RIILNQVVKGLIYLHSFNIVHRDLSLSNILLT----SSMDIKIADFGLSVT
                              ::  .: ::*   ::***:.  *:::.     .   *: ****:.

8635_Tthe       VNDENPECNTMCGTANYLSP-----------------EILNSKGYGKKTDIWSFGCILYA
PLK4_Hsap       LKMPHEKHYTLCGTPNYISP-----------------EIATRSAHGLESDVWSLGCMFYT
5034_Tthe       LNGNEQEKNTICGTPNYISP-----------------EILNKQPYGMKIDCWSFGCILYA
21183_Tthe      VTNYESERDTFCGTPNYIAP-----------------E-----KYGIQSDCWSFGCILYT
SAK_Spur        LKLPEEQHYTMCGTPNYISP-----------------EIATRGPHGLQSDVWSLGCMLYT
PLK4_Mmus       LNMPHEKHYTLCGTPNYISP-----------------EIATRSAHGLESDIWSLGCMFYT
SAK_Dmel        LKRPDERHMTMCGTPNYISP-----------------EVVSRTSHGLPADVWSVGCMLYT
zyg-1_Cele      LGRG-ETTCTIVGTPGFIAP-----------------QVYDQ-EYTQSADVYSLGAVLYT
AqueK201_Aque   LDLPGDKHHTLCGTPNYIAPYVICCYEGCFLIFIFCREVAKREAHGLESDIWSLGCMVYT
                :        *: **..:::*                 :      :    * :*.*.:.*:

8635_Tthe       LCSGNLPFFSGNPSQTIQNIKEGK--WQLPQNISDNVKDLLSNTLNWDQNSRFSIEQVLS
PLK4_Hsap       LLIGRPPFDTDTVKNTLNKVVLAD--YEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLD
5034_Tthe       LIVGHPPFQGQDIVQTLKKVTSQEQFFELPNNISDNLKDLLVNIINWNQDSRFTIDQILM
21183_Tthe      IATGRPPFETVSIQQTLKMLQKKN-KVEYPSHLSKSLVDLIDHILDWNQDTRYNISQIKS
SAK_Spur        FLTGTPPFDTEAVKTTLNKVMLAE--YIIPTHISMEAKDLINKMLRKDPTERIGLSTVLD
PLK4_Mmus       LLIGRPPFDTDTVKNTLNKVVLAD--YEMPAFLSREAQDLIHQLLRRNPADRLSLSSVLD
SAK_Dmel        LLVGRPPFETDAVQSTLNKVVMSE--YIMPAHLSYEAQDLINKLLKKLPHERITLEAVLC
zyg-1_Cele      MLTARNPPPKGLP-P--------------TCGMSPNAARLVEQMMDTDAKKRIPLTQIVL
AqueK201_Aque   MLVGTPPFDTDDVQSTLDNVVNGD--FDIPQYITTNCTSLNL--HVYHPSKRLTLQQVLY
                :  .  *                      .  :: .   *           *  :  :

8635_Tthe       HKFYEKKHKQSIIIFN-----------------------------QGADAISNQ-----Q
PLK4_Hsap       HPFMSRNSSTKSKDLG-----------------------------TVEDSIDSG-----H
5034_Tthe       HPFYEEMRQKSVKQRQ-----------------------------EEEESLSFF-----N
21183_Tthe      HPFYNKSKQNTHENEY-----------------------------KLQNPMTFAPPQPFQ
SAK_Spur        HPFMDKTRFNGTKNRP-LS---------------------K---RPVESSLDSG-----L
PLK4_Mmus       HPFMSRNPSPKSKDVG-----------------------------TVEDSMDSG-----H
SAK_Dmel        HPFMLKCSNGGHSAPG--A---------------------L---NVFSQSMESG-----D
zyg-1_Cele      SEFMYENTNENAVIFS--------------------------------------------
AqueK201_Aque   HSFTKGVQQENVLQKRTLSLTTPVIATYRGDCQFHGSRVLKNIQLEAPASVDSG-----N
                  *

8635_Tthe       NKLSTP-------------NKVLL-------------DWTSP-RFNAPIHLQQKSQSSQK
PLK4_Hsap       A-----------------------TISTAIT-----------AS--SS------------
5034_Tthe       SIRSVKGEDQRINVHQNGVKKIDIKYQDNFFNQLEHKEGSMPKKSNSPTNIHERKNQMIY
21183_Tthe      MEQSV-------NQNNKNIQQGHTRQRSNFS-----------MD--SS------------
SAK_Spur        A-----------------------TMATISS-----------SH--TS------------
PLK4_Mmus       A-----------------------TLSTTIT-----------AS--SG------------
SAK_Dmel        S-----------------------GIITFAS-----------SD--SR------------
zyg-1_Cele      ------------------------------R-----------EH--SR------------
AqueK201_Aque   V-----------------------TLATNYS-----------GP--TS------------
                                                              :

8635_Tthe       KNKRISNLKNQKS----LTSMKLDLSDCNKENQPNLINSSNNKSNNTAIIEKQKSTKSNT
PLK4_Hsap       ------------------TSISG-------------------------------------
5034_Tthe       KNDQIAALKNNKIQNEDL-------------NIMS--NNLNQIQYKKQSQNN--LVKQND
21183_Tthe      --NNSKHFQQNKIMNDNL-------------YQINNINRSNQIQENNVLQNK--QTKENR
SAK_Spur        ------------------NRTSS-------------------------------------
PLK4_Mmus       ------------------TSLSG-------------------------------------
SAK_Dmel        ------------------NSQQI-------------------------------------
zyg-1_Cele      ------------------DG----------------------------------------
AqueK201_Aque   ------------------R-YST-------------------------------------


8635_Tthe       YKEQQ--NIQSNQQNSLGMSNIFLTTARSINLADNSIIMSTLQDNQLNNTNNK-KENTKP
PLK4_Hsap       ----------------------------------------------SLFDKRR-LLIGQP
5034_Tthe       KQILNQKEINFARKNS------------------PVDRFDVENQQNNMNKQKDDASHTVK
21183_Tthe      FQSKEQLLVNENKENI------------------HSNILNSINNQQKLFQQQQ-KLNPIP
SAK_Spur        --------------------------------------------------RSR-PMRALP
PLK4_Mmus       ----------------------------------------------SLLD-RR-LLVGQP
SAK_Dmel        ----------------------------------------------RSVENSG-PQQVL-
zyg-1_Cele      ------------------------------------------------------------
AqueK201_Aque   --------------------------------------------------RRG-------


8635_Tthe       TQKLQYYLQQNSNTSQQLKQSS--------------------------------------
PLK4_Hsap       LPNKMTVFPKNKSSTDFSSS-GDGNSFYTQWGN---------------------------
5034_Tthe       VKEIHSHNQQLNIRKQSPTNQILNYDK------DKIAIPERKSLTQQSQAINQNDVFKSP
21183_Tthe      LQKSYSYNQKNEQKQDQILHQTLAQGLKKEVSEQSIDNNRNKQIIQEIQNISQNSYY---
SAK_Spur        LSTLTPVISEGEGSRGQVKGHHHGDGIGSSWNQ---------------------------
PLK4_Mmus       LPNKITVFQKNKNSSDFS-S-GDGSNFCTQWGN---------------------------
SAK_Dmel        ------------------------------------------------------------
zyg-1_Cele      ------------------------------------------------------------
AqueK201_Aque   -PVKATFFPSS-------------------------------------------------


8635_Tthe       ------------------------------------------------------------
PLK4_Hsap       --------------------------QETSNSGRGRVIQDA-------------EERP--
5034_Tthe       KLTSNQQEIKQTFINNIEKIKSNQPPVPQNQQQQNNSAITT-------------YGGQ--
21183_Tthe      -----------------------NPQISQSNKQQQQQIDTI-------------QQKP--
SAK_Spur        --------------------YD-R--HPPSPPVRQRANHSAALQSRSEQAGETLESRPWF
PLK4_Mmus       --------------------PE----QEANSRGRGRVIEDA-------------EERP--
SAK_Dmel        --------------------------------------PQI-------------REEF--
zyg-1_Cele      ------------------------------------------------------------
AqueK201_Aque   --------------------------------G-SHLQEDQS------------RKAT--


8635_Tthe       -------------------------------------------ILNNQGQASGYNNSRNR
PLK4_Hsap       ---------HSRYLRRAYSSDRSGT-------------------SNSQSQAKTYTME---
5034_Tthe       ---------EKRGVKSIVY-NNSNNQNNINTNQNSNQYNIQNSITNNQINPTNNYKTVNS
21183_Tthe      ---------QSKTILNTFL-NKATKSNSLHQS--------------SSTTPSSNQQNINT
SAK_Spur        SGAALKQKASSSQDLRMTSSDRMQPH-----------------VSSHTSQTRDYNLT-AK
PLK4_Mmus       ---------HSRYLRRAHSSDRASP-------------------SN-QSRAKTYSVE---
SAK_Dmel        ---------KQVHHKLPY------------------------------------------
zyg-1_Cele      --------------RRQRSREPVRS-------------------SR-DDRSRDG------
AqueK201_Aque   ---------SGLHHRRAHSLE---------------------------------------


8635_Tthe       FDLSCNNVINQNKSQQSLLQYNGYKSQSVIPQQQQAFSQNSQQISNKNQPQQQNTKELT-
PLK4_Hsap       -----------------------RCHSAEML----------SVSKRSG-----GGENEER
5034_Tthe       SNINNNYYSNTSQSQQF---INGINHQHDIHSRTAANSNHDKYIKNTN-----NIRNNS-
21183_Tthe      NNFFQSQKSYKNPIVQI---LNGF------------------------------------
SAK_Spur        PSINDGSMKGFD-TKTR---GMYQSHEQDIHRSQGHVYHDDAQVKRSG-----SWKSQEF
PLK4_Mmus       -----------------------RCHSVEML----------SKPRRS-------------
SAK_Dmel        -------------------------------EQTG-LFGQA-------------------
zyg-1_Cele      ----------------R---ALIRSSSQPAH-----------------------------
AqueK201_Aque   ------------------------------------------------------------


8635_Tthe       --PKQFNPYL---SQN--------------------------------------------
PLK4_Hsap       YSPTDNNANIFNFFKEKT-SSSSGSFER---PDN----NQALSNHLCPGKT---PF---P
5034_Tthe       --PVNNNSYI---ERNQSPNTQNNHMSSSSVLNNGQQQSQHKNNSYSISQSKVIPL----
21183_Tthe      ----PNDSKI---QQNQAINHQKNK---------------------SLDISGIIP-----
SAK_Spur        ---LGQHGSV---LREKSRTETSGHYDR---VDD----AK--------------------
PLK4_Mmus       -------------------------------LDE----NQHSSNHHCLGKT---PF---P
SAK_Dmel        -------ST-------------------------------GLAE----------------
zyg-1_Cele      -----------------------------------------------SGRA---PLSNRP
AqueK201_Aque   ------------------------------------------------------------


8635_Tthe       -------SEKTQQDYSN--NAFKSYRSTSSLHQNISIANT-SQTYRNPLQESQINKNNQQ
PLK4_Hsap       FADPTPQTETVQQWFGN--LQINAHLRKTTEYDSISPNRD-FQGHPDLQKDTSKNAWTDT
5034_Tthe       -------PKKVQTSFLQNLNSLTDVDRFSPPHNNTNSTNTTTNNYVN-IQ-SEINNFPQP
21183_Tthe      ---------------------------------------------------------PQP
SAK_Spur        -------------------------HRLFSEADIDSDRR---QDLT-VRTDHAKDKCTDK
PLK4_Mmus       FADQTPQMEMVQQWFGN--LQMNAHLGETNEHHTVSPNRD-FQDYPDLQ-DTLRNAWTDT
SAK_Dmel        -----------PNWPGA--AKSS-------------------------------------
zyg-1_Cele      IHDRMPS-----------------------------------------------------
AqueK201_Aque   ------------------------------------------------------------


8635_Tthe       RQEAFDNTKQALHNVK-------K--PLQYFSQQQ----QTQKD--GDNQMFTQSQNN--
PLK4_Hsap       KVKKNSDASDNAHSVK-------QQNTMKYMTALH----SK--PEIIQQEC------VFG
5034_Tthe       QTVSHNRTKNQVSFEN-------K--PIQAQVQNQ----TTQKVMQSSDQGFYKKNNNPP
21183_Tthe      PR-PRDEQKNQLSFKTIDQENIQK--KQISIDQSNQNEFVTTPS--GNNKMFSQSSNN--
SAK_Spur        KQSAQSSVSDHP-SVH-------GMHAAVPSSASC-----G--GLSSKQDGALHKDSKAG
PLK4_Mmus       RASKNADTSANVHAVK-------QLSAMKYMSAHH----HK--PEVMPQE--------PG
SAK_Dmel        ---------------------------------------------------AFCME--AG
zyg-1_Cele      -------------------------------TSSR--------GFDSERGRERDRDSGRG
AqueK201_Aque   ------------------------------------------------------------


8635_Tthe       ----------NTNKQMKGDNTLNG------------------------NLKYSSL-STNS
PLK4_Hsap       SDPLSEQSKTRGMEPP-------W--------------------------------GYQN
5034_Tthe       QSVQTNLQRNQSPQLHVGNKNTSD------------------------NLNYYLTKKDHP
21183_Tthe      ----------MIFMKENNNSKIQN------------------------VKKKMSL-----
SAK_Spur        ERSSHRRSKSKSHDLD-------KGSEWTHRHTRKHEKREGGGGGGKGEG------GAGV
PLK4_Mmus       LHPHSEQSKNRSMEST-------L--------------------------------GYQK
SAK_Dmel        NVPNSKQASLK-------------------------------------------------
zyg-1_Cele      TVPPSREDRN--------------------------------------------------
AqueK201_Aque   ------------------------------------------------------------


8635_Tthe       QTLN--------------------------KNDESYIHNYHQ------------------
PLK4_Hsap       RTLRSITSPLVAHRLKPIRQKTKKAVVSILDSEEVCVELVKE-----YASQ----EYVKE
5034_Tthe       QCVE--------------------------DQADKYEEIIHQ-----RKNENKIINRENN
21183_Tthe      ------------------------------------------------------------
SAK_Spur        QSLAHLTPPLNATRLRPIRQRTRNAVVSIMLGGEVCLEFLKT-----KDGQ----DRVVE
PLK4_Mmus       PTLRSITSPLIAHRLKPIRQKTKKAVVSILDSEEVCVELLRE-----CASE----GYVKE
SAK_Dmel        -EDRISVPPLNTKRLLPTRYKTKNAIMSILRNGEVVLEFLKF---RPTYNE----DRIND
zyg-1_Cele      ---RSQLWPIRMDRLEGQRVCT--------AGGRYIVELDTRCRFEVAAQG----NFVKR
AqueK201_Aque   -----------------------------------------------------------D


8635_Tthe       -PRIRSQQSQQNVNLREK---S-PSCQF-IQKNQEISSQNNCDGIKDLQNINKI-----Q
PLK4_Hsap       VLQISSDGN--TITIYYP---N-GGRGF-PLADR-PPSPT--------------------
5034_Tthe       IKRISSEQNISRVSTEYK---N-GSNDF-NTQNK-LNNQYNNNKINIDYTSNQLM--NNN
21183_Tthe      -----------HFPTEQT---N-ISQDIISTNTT-CRNNITTTMTFPSPSSQQFLAQNNN
SAK_Spur        VLRISQDGM--QVTIYQP---N-GGKGF-PIMEH-PPSPP--------------------
PLK4_Mmus       VLQISSDGT--MITVYYP---N-DGRGF-PLADR-PPLPT--------------------
SAK_Dmel        ICRISDDGQ--RIIIYQP---D-PGRGL-PVREQ-PPDLQ--------------------
zyg-1_Cele      ILIVEVDEM--VQTVYVHRIPDRTVRGR-NGEEE-LITLT--------------------
AqueK201_Aque   VCRGNDEIM---------------------------------------------------


8635_Tthe       QNSQIKRNYSQQITPKEMQTNSNIQ---KLEYA----------------NRISQLCAKGD
PLK4_Hsap       ------------------------------------------------------------
5034_Tthe       QQYKINQEYNQNKLSNDFSSNNNKMNNNYVSNKINTEYNTNKMINHDNPNRMSNEINKSN
21183_Tthe      NQIIINQNIQRQKPSKSTHNN----DNNHTSFDIS-------------------------
SAK_Spur        ------------------------------------------------------------
PLK4_Mmus       ------------------------------------------------------------
SAK_Dmel        ------------------------------------------------------------
zyg-1_Cele      ------------------------------------------------------------
AqueK201_Aque   ------------------------------------------------------------


8635_Tthe       HNFLLEKKSSSNSNNNCQQ--------------NVQSSKNIRSLSNSQF-----------
PLK4_Hsap       ------------------------------------------------------------
5034_Tthe       VDHYSNKNNSDFNKINVDYNSNKINYDPNKANIDYSSNNKINIEFNSNNKINNGYVSNKV
21183_Tthe      ---YLKLDSSQMNSFSVER--------------DFQSTAQFSSKSNVIHTPTNVSISQKP
SAK_Spur        -----------------------------------------------------------Q
PLK4_Mmus       ------------------------------------------------------------
SAK_Dmel        -----------------------------------------------------------I
zyg-1_Cele      ------------------------------------------------------------
AqueK201_Aque   ------------------------------------------------------------


8635_Tthe       ----------------------------TINSNIKQ------------------------
PLK4_Hsap       -DNIS-RYSFDN-LPEK-------YWRKYQYASRF--VQLV-------------------
5034_Tthe       TSEVN-KYNYES-NHNKYGNEQNQYKIKYEFSSPK--MNTEQNTSRLNTDYKGTRLNTDF
21183_Tthe      PSNKN-SYTYRDINPPSFAPSQQPTSLMRAKGSSKEYIKTEPCDIDVNQTPRLECLETE-
SAK_Spur        DSGIT-KHSYHD-LPSK-------YWKKYQYASRF--IQLV-------------------
PLK4_Mmus       -DNIS-RYSFDN-LPEK-------YWRKYQYASRF--IQLV-------------------
SAK_Dmel        PSGDC-VYNYDN-LPSK-------HWKKYIYGARF--VGLV-------------------
zyg-1_Cele      -NNPFVYTSYSQ-MPKE-------VQNDYMRLQKM--VAVT-------------------
AqueK201_Aque   ------------------------------------------------------------


8635_Tthe       ------------------------------------------------------------
PLK4_Hsap       ---------------------------------RSKSPKITYFT----RYAKC-ILMENS
5034_Tthe       NNTRDNTECNTQRLNTEQNTARLTTEQYNPQRVISKNKAIMF----SMDNLQGKLNMENA
21183_Tthe      ------------------------------------------------------------
SAK_Spur        ---------------------------------RSKTPKVTLYT----PHAKC-MLMENG
PLK4_Mmus       ---------------------------------RSKTPKITYFT----RYAKC-ILMENS
SAK_Dmel        ---------------------------------KSKTPKVTYFS----TLGKC-QLMETM
zyg-1_Cele      --------------------------------ISGRVAKVTFRRPSQFPDAQA-QLMENG
AqueK201_Aque   ------------------------------------------------------------


8635_Tthe       -------------------KIQKDTSELS----------------IQVTDRQ--------
PLK4_Hsap       PGADFEVWFY------DGVKIHKTE-D-F----------------IQVIEKTG-------
5034_Tthe       NN---RISVEQNINGRFNNEIMKTNNENLILKNGNAQNILNTNAHPKIIDKKQKSEVPLI
21183_Tthe      ------------------------------------------------------------
SAK_Spur        PTADCEACFY------DGTKIHATS-V-E----------------LEVTESNG-------
PLK4_Mmus       PGADFEVWFY------DGAKIHKTE-N-L----------------IHIIEKTG-------
SAK_Dmel        --TDFEIRFY------SGAKLLKTPSE-G----------------LKVYDRNG-------
zyg-1_Cele      ---DLRIKLP------RSVIVRKMD-N-------------------------G-------
AqueK201_Aque   ------------------------------------------------------------


8635_Tthe       --------------ITFQGNEQNEKINFTK-----------------------SPTQIQT
PLK4_Hsap       -------------------------------------------------------KSYTL
5034_Tthe       SQIANQPMRSSQVQLTQQQQQQNIPITFLNEDRDLYKKQEKFDKVKHFKNQTSDNANYSL
21183_Tthe      ---------------------NNENT------------------------STAACSKYSM
SAK_Spur        -------------------------------------------------------QTCKL
PLK4_Mmus       -------------------------------------------------------ISYNL
SAK_Dmel        -------------------------------------------------------MLLSD
zyg-1_Cele      -------------------------------------------------------EIFNC
AqueK201_Aque   ------------------------------------------------------------


8635_Tthe       RNNSKSFSQSVNCAPIASSKERKVSFV-AQSA-DLQEQ----------------------
PLK4_Hsap       KSESEVNSLKEE---------IKMYMDHANEGHRICLALESIISEEERKTRSAPFFPIII
5034_Tthe       NNTNNINGSNEY---------NKEFFN-AQYQQQLQDQQEKMMNSKVNTYRNSQIFESQV
21183_Tthe      NTTNRSFNKGLN---------TSKSFS-SFIA-DQTNEIDKYSNNIQLNQQNSNIITSQI
SAK_Spur        PADQNNDQIPSH---------LKPIISSFYTWRQHCVDVESAIASLESRHGYGPFFPLIL
PLK4_Mmus       KNENEVTSLKEE---------VKVYMDHANEGHRICLSLESVISEEEKRSRGSSFFPIIV
SAK_Dmel        YSCSES----------------RSLIEHGNECFTHCVNISNALEVA--QTKDNSCFPVTI
zyg-1_Cele      ID--GIATQKQAV--------SGITLTKVNEVYKYLIRFEQCLNGM---DRGMVCFPIVF
AqueK201_Aque   -------------------------------------KLS-------------NCF----


8635_Tthe       ----I-QII---------------------------------------------------
PLK4_Hsap       GRKPG-STS---------------------------------------------------
5034_Tthe       GTQRV-QAV---------------------------------------------------
21183_Tthe      SPVKV-------------------------------------------------------
SAK_Spur        SRKPL-QESYQQGNKLPASTN-IRTSAVTSHTTPATTTTTSTTTVPPSTTPHPSGPTQAC
PLK4_Mmus       GRKPG-NTS---------------------------------------------------
SAK_Dmel        GRRPI-TDV---------------------------------------------------
zyg-1_Cele      SAGTNMVGS---------------------------------------------------
AqueK201_Aque   SGE--------QSVSFSLKDNDVPSSSVYSQRDPVTC-----------------------


8635_Tthe       ------QSKSTQQTG---------------------------------------------
PLK4_Hsap       ------SPKALSPPPS--------------------------------------------
5034_Tthe       ------KSKSRIQSGL--------------------------------------------
21183_Tthe      --------------GD--------------------------------------------
SAK_Spur        PQGSVTSPSVMAAPTASVCSFDGTICSVARSVQGKDRTRHRKIDKGGSSKEASKVTSQAS
PLK4_Mmus       ------SPKALSAPPV--------------------------------------------
SAK_Dmel        ------QPAQRL-DGL--------------------------------------------
zyg-1_Cele      ------SPSSLMPSGS--------------------------------------------
AqueK201_Aque   ------------------------------------------------------------


8635_Tthe       ------------------------------------------------------------
PLK4_Hsap       ------------------------------------------------------------
5034_Tthe       ------------------------------------------------------------
21183_Tthe      ------------------------------------------------------------
SAK_Spur        SHPEGKDGVLKSVFVPNIGWASQMSSGEVRVQYNDGSMILVHAATSTIKYMDSQGKGQRA
PLK4_Mmus       ------------------------------------------------------------
SAK_Dmel        ------------------------------------------------------------
zyg-1_Cele      ------------------------------------------------------------
AqueK201_Aque   ------------------------------------------------------------


8635_Tthe       ----------------------------------------------------------AV
PLK4_Hsap       ----------------------------------------VDS-NYPTRERASFNRMVMH
5034_Tthe       ----------------------------------------------------------KT
21183_Tthe      ----------------------------------------------------------DL
SAK_Spur        QWKKWIRWRQHCVDVESAIASLESRHGYGPFFPLILSRKPLQE-SYQQGNKVTASKNIRT
PLK4_Mmus       -----------------------------------------DP-SCCKGEQASASRLSVN
SAK_Dmel        ----------------------------------------RDTTNIAF------------
zyg-1_Cele      ----------------------------------------SQTSRF------PFSNLSNN
AqueK201_Aque   ------------------------------------------------------------


8635_Tthe       NFA-DSKTQYQSNDTNSSFPVSPLSTQGLKANK------------VNTKNGIIE-----I
PLK4_Hsap       SAA-SPTQAPI---------LNPSMV-----TNEG---------------------LGLT
5034_Tthe       DVS-DSETNSISNQNSTTNNLEYYE-----SPR------------INTLNLMLSPERRIP
21183_Tthe      DVS-----------------------------K------------IKTKNGYIE-----I
SAK_Spur        SAA-TSHTTPATTATS-TNTVPPSTT-----PHPGGPTQACPQGSVTSPS------VMAA
PLK4_Mmus       SAA-FPTQSPG---------LSPSTV-----TVEG---------------------LGHT
SAK_Dmel        -------STPKSNQGS----INFSLS-----TI--------------------------S
zyg-1_Cele      QPSLVPHSAPF---------LTKPT----------------------------------S
AqueK201_Aque   ------------------------------------------------------------


8635_Tthe       SEN------------------------NWLSIECQNGQL---------------------
PLK4_Hsap       TTA------------------------SGTDI------------SSN--------SLKDC
5034_Tthe       TTN------------------------NSTAVKN-NSQMKNLLSGNKDNSSCKNNSNNTS
21183_Tthe      TSD------------------------HSLLVESCNGRL---------------------
SAK_Spur        PTASVCSFDGTICSVARSVQGKDRTRHRKTDK------------GGSSKEACKVTSQASS
PLK4_Mmus       ATA------------------------TGTGV------------SS-------------S
SAK_Dmel        STR------------------------NTSDF------------GTN--------CSRSN
zyg-1_Cele      SQR------------------------AS---------------SAN--------V-QRR
AqueK201_Aque   --------------ISR-------------------------------------------


8635_Tthe       IFKISPNGEQV---------------------------------------------VCQT
PLK4_Hsap       ---LPKSA-Q-------------------------------------LLKSVFVKNVGWA
5034_Tthe       RKNTSKQNNNLKWNDRNNRRKRIHSSVNLKKHNDGDFSRWQRCHVDKVRRAFKQKTLQKN
21183_Tthe      LFKISKDGQKIQINKLIDKPMEKHYTLNN----LPAKYYALYGY---------AKQVINA
SAK_Spur        ---HPEGKDG-------------------------------------VLKSVFVPNIGWA
PLK4_Mmus       ---LPKSA-Q-------------------------------------LLKSVFVKNVGWA
SAK_Dmel        ---MLAAHQN------------------------------------IPIKRINVPEIGIA
zyg-1_Cele      ---VSTDEN--------------------------------------SSPSVAPSKYKIK
AqueK201_Aque   ------------------------------------------------------------


8635_Tthe       LKS-KTPLVKIQNEKGTFMLMSNQPKQNYEVSLSNGYKVSHVIGTDIMTVKDKQNKEFIV
PLK4_Hsap       TQL-TSGAVWVQFNDGSQLVVQAG-----------------------------VS--SIS
5034_Tthe       AQD-KSAKVKLENEDGQFYLYENK----FEGVFSNGFIVNYKLNSQNLEIQTNKYAPKIV
21183_Tthe      LKT-KKVISKLENKEGIFILLENN---CFEAQFKTGYKIYYKNKNASMKIKAPDNNIYEI
SAK_Spur        SQM-SSGEVRVQYNDGSMILVHAT-----------------------------TS--TIK
PLK4_Mmus       TQL-TSGAVWVQFNDGSQLVVQAG-----------------------------VS--SIS
SAK_Dmel        TEL-SHGVVQVQFYDGSVVSVIPS---------------------------MQGG--GIT
zyg-1_Cele      IDPTTQKVRSIQATDGRVLRCST----------------------------SKAD--QFI
AqueK201_Aque   ------------------------------------------------------------


8635_Tthe       YLSQQ--NL------NKSIPQEITLAVKVSLEQMSSCLQKQ-------------------
PLK4_Hsap       YTSPNG--QTTRYGENEKLPDYI---K-QKLQCLSSILLMF-------------------
5034_Tthe       F-DLQ--KD------LKHASKEMKTIVQ-KTQKIISII----------------------
21183_Tthe      --SLE--KN------SKDFPQEVKNITS-KSLKYYEYLLN--------------------
SAK_Spur        YMDSQG--KGQSYGRNAVLPSHI---R-EKLLHMPHIIQLF-------------------
PLK4_Mmus       YTSPDG--QTTRYGENEKLPEYI---K-QKLQCLSSILLMF-------------------
SAK_Dmel        YTQPNG--TSTHFGKGDDLPFPV---R-DRVGQIPNIQLKLKTAPLLGSGRKTDYNNAMT
zyg-1_Cele      FTDPAIRPDDQRFMRTDRVPDRA---S-EMLHTLCER-----------------------
AqueK201_Aque   ---------------NSSLDSSV---S-ERRTT---------------------------


8635_Tthe       ----NEQYLANFK
PLK4_Hsap       -----SNPTPNFH
5034_Tthe       --------TSMKS
21183_Tthe      -----QNKEFQNI
SAK_Spur        -----VN-QNKPT
PLK4_Mmus       -----SNPTPNFQ
SAK_Dmel        PKTTTPYYNRMLL
zyg-1_Cele      -------MRKLHQ
AqueK201_Aque   ---ANSTMVSKCI