Kinase Family LISK
From WikiKinome
Kinase Classification: Group TKL: Family LISK
The LISK family consists of two main subfamilies:
LIMK
(LIM domain kinases)
TESK
(Testis Expressed Serine Kinases)
A separate subfamily, LISK-DD1 has been reported only from Dictyostelium, and some fungi
Evolution
LISK-DD1 is seen in Dictyostelium and at least one fungus, while the other two are animal-specific.
Functions
Both TESK and LIMK subfamilies phosphorylate cofilin and inhibit its actin-capping function.
