Kinase Family Lmr

Kinase Classification: Group TK: Family Lmr

An unusual and poorly-studied family of receptor tyrosine kinases. Most Lmr kinases are anchored in the membrane but have little or no extracellular region. They have a juxtamembrane kinase domain and a long, poorly conserved, C-terminal tail (the symbol Lmr, coined at Sugen, refers to the long tails of Lemurs). Vertebrates have three Lmr kinases (LMTK1-3), with one Lmr in many metazoans, though the family has been lost from both insects and nematodes. Lmr1 is the best studied member, also known as AATYK (Apoptosis-associated tyrosine kinase).

References

1. Ahier A, Rondard P, Gouignard N, Khayath N, Huang S, Trolet J, Donoghue DJ, Gauthier M, Pin JP, and Dissous C. A new family of receptor tyrosine kinases with a venus flytrap binding domain in insects and other invertebrates activated by aminoacids. PLoS One. 2009 May 21;4(5):e5651. DOI:10.1371/journal.pone.0005651 |