Kinase Family PRR1

Kinase Classification: Group CAMK: Family PRR1

PRR1 (SGD) is a yeast kinase that inhibits pheromone signaling, downstream of the MAPK kinases [1]. Up until 2011, it was classified as CAMK-Unique, but then was placed in its own family, due to the presence of orthologs in other fungi including basidiomycetes such as Coprinopsis cinerea. The protein has multiple inserts within the kinase domain, of varying length in different orthologs, making blast-based homology comparisons difficult. It may be a member of the CAMKL family, but this needs more investigation. No clear homologs are found outside of fungi, but this has not been examined in depth.

References

1. Burchett SA, Scott A, Errede B, and Dohlman HG. Identification of novel pheromone-response regulators through systematic overexpression of 120 protein kinases in yeast. J Biol Chem. 2001 Jul 13;276(28):26472-8. DOI:10.1074/jbc.M103436200 |