Kinase Family RSKR

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Kinase Classification: Group AGC: Kinase Family RSKR

RSKR are RSK-Related kinases, first named in the human [1] and Drosophila[2] kinome papers. The family is closely related to RSK and RSKL families, and is found only in bilateral animals. All have a central kinase domain with weakly conserved flanking regions. The human RSKR, SgK494 is uncharacterized, and the Drosophila homolog Pk17E has only been characterized as part of large-scale screens, making this one of the more mysterious of kinase families.


References

  1. Manning G, Whyte DB, Martinez R, Hunter T, and Sudarsanam S. The protein kinase complement of the human genome. Science. 2002 Dec 6;298(5600):1912-34. DOI:10.1126/science.1075762 | PubMed ID:12471243 | HubMed [Manning1]
  2. Manning G, Plowman GD, Hunter T, and Sudarsanam S. Evolution of protein kinase signaling from yeast to man. Trends Biochem Sci. 2002 Oct;27(10):514-20. DOI:10.1016/s0968-0004(02)02179-5 | PubMed ID:12368087 | HubMed [Manning2]
All Medline abstracts: PubMed | HubMed