Kinase Group RGC

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Kinase Classification: RGC Group

RGCs are Receptor Guanylate Cyclases that have an unusual structure: they are single-pass transmembrane receptors that have an active guanylate cyclase domain and a catlytically inactive kinase domain on the intracellular side. The guanylate cyclase domain makes the second messenger cGMP, and the kinase domain may have a regulatory role and may bind ATP.

Evolution

RGCs are seen in animals and choanoflagellates.

Families

No families have yet been defined within the RGC group, though several conserved classes are clear.

Kinase Domain Function

The kinase domains of animal RGCs lack the catalytic HRD motif and are classified as pseudokinases. However, some are known to bind ATP [1] and this is thought to cause conformational change and to regulate the activity of the guanylate cyclase domain [2].

References

  1. Jaleel M, Saha S, Shenoy AR, and Visweswariah SS. The kinase homology domain of receptor guanylyl cyclase C: ATP binding and identification of an adenine nucleotide sensitive site. Biochemistry. 2006 Feb 14;45(6):1888-98. DOI:10.1021/bi052089x | PubMed ID:16460035 | HubMed [Jaleel]
  2. Duda T, Yadav P, and Sharma RK. Allosteric modification, the primary ATP activation mechanism of atrial natriuretic factor receptor guanylate cyclase. Biochemistry. 2011 Feb 22;50(7):1213-25. DOI:10.1021/bi1018978 | PubMed ID:21222471 | HubMed [Duda]
All Medline abstracts: PubMed | HubMed