Kinase Subfamily DAPK

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Kinase Classification: Group CAMK: Family DAPK: Subfamily DAPK


Evolution

DAPK kinases are found in animals, including sponges, but lost from a number of lineages, including Drosophila and other dipterans, Trichoplax, and Nematostella. C. elegans has a single DRAK, K11C12.4/dapk-1, while mammals have three, DAPK1-3.


Domain Structure

DAPK kinases have an N-terminal kinase domain and a variable C terminal extension. The ancestral state, found in human DAPK1 and nematode K12C11.4 has ankyrin repeat region followed by ROC and COR domains and a death domain. Vertebrate DAPK2 and DAPK3 lack these additional domains. Several invertebrates, including all beetles and Aplysia appear to have lost just the kinase domain. A splice isoform of human DAPK1 lacks the kinase domain [1] and causes degradation of the full-length form, and C. elegans may also have splice isoforms (isoforms c, d) that lack the kinase domain.

Functions

References

  1. Lin Y, Stevens C, Harrison B, Pathuri S, Amin E, and Hupp TR. The alternative splice variant of DAPK-1, s-DAPK-1, induces proteasome-independent DAPK-1 destabilization. Mol Cell Biochem. 2009 Aug;328(1-2):101-7. DOI:10.1007/s11010-009-0079-4 | PubMed ID:19267229 | HubMed [Lin]