User:Roland Dunbrack

Professor, Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia PA

I have a research group in computational structural biology, focusing on structural bioinformatics and methods for protein structure prediction. We are particularly interested in modeling of oligomeric complexes. Our ProtCID website (http://dunbrack2.fccc.edu/protcid) has information on homo- and heterodimeric interactions of proteins observed in multiple crystal forms. The page on kinases (browse the Pfam families for (Pkinase) and (Pkinase_Tyr) have several commonly observed dimer interactions. For instance, the asymmetric EGFR dimer is observed in several EGFR crystals and also Erbb2 and Erbb4.