View source for Kinase Family PKN

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[[kinase classification|Kinase Classification]]: [[Kinase_Group_AGC|Group AGC]]: [[Kinase_Family_PKN|Family PKN]]


====Evolution====
PKN is found across metazoans, with 3 genes (PKN1, PKN2, PKN3) in mammals

====Domain Structure====
PKNs have an array of 3 HR1 domains in the N-terminus, followed by a C2 domain and a kinase domain, a similar organization to that of fungal PKCs, though without their C1 domains

====Functions====
PKN is activated by Rho GTPases though the HR1 domains (similar to fungal PKCs), and has a wide range of substrates and functions.

====References====
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