View source for Kinase Subfamily DAPK

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[[kinase classification|Kinase Classification]]: [[Kinase_Group_CAMK|Group CAMK]]: [[Kinase_Family_DAPK|Family DAPK]]: [[Kinase_Subfamily_DAPK|Subfamily DAPK]]

 

====Evolution====
DAPK kinases are found in animals, including sponges, but lost from a number of lineages, including Drosophila and other dipterans, Trichoplax, and Nematostella. C. elegans has a single DRAK, K11C12.4/dapk-1, while mammals have three, DAPK1-3.


====Domain Structure====
DAPK kinases have an N-terminal kinase domain and a variable C terminal extension. The ancestral state, found in human DAPK1 and nematode K12C11.4 has ankyrin repeat region followed by ROC and COR domains and a death domain. Vertebrate DAPK2 and DAPK3 lack these additional domains. Several invertebrates, including all beetles and Aplysia appear to have lost just the kinase domain. A splice isoform of human DAPK1 lacks the kinase domain <cite>Lin</cite> and causes degradation of the full-length form, and C. elegans may also have splice isoforms (isoforms c, d) that lack the kinase domain.

====Functions====


====References====
<biblio>
#Lin pmid=19267229
</biblio>