Difference between revisions of "E91"
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[[Kinase Glossary]]: [[E91]] | [[Kinase Glossary]]: [[E91]] | ||
| − | [[E91]] is a key conserved residue in [[ePK]] and most [[PKL]] kinases. It forms a salt bridge with [[K72]]. It is found in the C helix, though it is not part of a larger motif, making it difficult to detect in some remote kinases. The number 91 is based on the position of this residue in the first PKA kinase crystal <cite> | + | [[E91]] is a key conserved residue in [[ePK]] and most [[PKL]] kinases. It forms a salt bridge with [[K72]]. It is found in the C helix, though it is not part of a larger motif, making it difficult to detect in some remote kinases. The number 91 is based on the position of this residue in the first PKA kinase crystal <cite>taylor1993</cite>. It is a D in some PKL kinases. |
<biblio> | <biblio> | ||
| − | # | + | #taylor1993 pmid=15299527 |
</biblio> | </biblio> | ||
Latest revision as of 21:05, 13 May 2014
Kinase Glossary: E91
E91 is a key conserved residue in ePK and most PKL kinases. It forms a salt bridge with K72. It is found in the C helix, though it is not part of a larger motif, making it difficult to detect in some remote kinases. The number 91 is based on the position of this residue in the first PKA kinase crystal [1]. It is a D in some PKL kinases.
- Zheng J, Trafny EA, Knighton DR, Xuong NH, Taylor SS, Ten Eyck LF, and Sowadski JM. 2.2 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MnATP and a peptide inhibitor. Acta Crystallogr D Biol Crystallogr. 1993 May 1;49(Pt 3):362-5. DOI:10.1107/S0907444993000423 |
