E91

Kinase Glossary: E91

E91 is a key conserved residue in ePK and most PKL kinases. It forms a salt bridge with K72. It is found in the C helix, though it is not part of a larger motif, making it difficult to detect in some remote kinases. The number 91 is based on the position of this residue in the first PKA kinase crystal. It is a D in some PKL kinases.