E91

Kinase Glossary: E91

E91 is a key conserved residue in ePK and most PKL kinases. It forms a salt bridge with K72. It is found in the C helix, though it is not part of a larger motif, making it difficult to detect in some remote kinases. The number 91 is based on the position of this residue in the first PKA kinase crystal [1]. It is a D in some PKL kinases.

1. Knighton DR, Zheng JH, Ten Eyck LF, Ashford VA, Xuong NH, Taylor SS, and Sowadski JM. Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Science. 1991 Jul 26;253(5018):407-14. DOI:10.1126/science.1862342 |