Difference between revisions of "EPK"
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Revision as of 15:48, 21 August 2011
Kinase Glossary: ePK
ePK stands for eukaryotic Protein Kinase. Most eukaryotic protein kinases belong to this superfamily. ePKs themselves are part of the PKL or Protein Kinase-Like fold, and share a common protein fold and catalytic mechanism. ePKs have a number of specific characteristics, including more elaborate regulatory mechanisms [1], and are exclusively protein kinases, while other PKLs also phosphorylate various small molecules.
Human kinases have been classified into typical ePKs and Atypical kinases [2] that include both other PKLs and other kinase types. More recently [1], several typical kinases have been split off into other PKL classes, such as Bub, Haspin, and Bud32.
See also: Protein Kinase Evolution