Difference between revisions of "Kinase Family Lmr"
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| − | [[kinase classification|Kinase Classification]]: [[Kinase_Group_TK|Group TK]]: [[ | + | [[kinase classification|Kinase Classification]]: [[Kinase_Group_TK|Group TK]]: [[Kinase_Family_Lmr|Family Lmr]] |
An unusual and poorly-studied family of receptor tyrosine kinases. Most Lmr kinases are anchored in the membrane but have little or no extracellular region. They have a juxtamembrane kinase domain and a long, poorly conserved, C-terminal tail (the symbol Lmr, coined at [http://en.wikipedia.org/wiki/SUGEN Sugen], refers to the long tails of Lemurs). Vertebrates have three Lmr kinases (LMTK1-3), with one Lmr in many metazoans, though the family has been lost from both insects and nematodes. Lmr1 is the best studied member, also known as AATYK (Apoptosis-associated tyrosine kinase). | An unusual and poorly-studied family of receptor tyrosine kinases. Most Lmr kinases are anchored in the membrane but have little or no extracellular region. They have a juxtamembrane kinase domain and a long, poorly conserved, C-terminal tail (the symbol Lmr, coined at [http://en.wikipedia.org/wiki/SUGEN Sugen], refers to the long tails of Lemurs). Vertebrates have three Lmr kinases (LMTK1-3), with one Lmr in many metazoans, though the family has been lost from both insects and nematodes. Lmr1 is the best studied member, also known as AATYK (Apoptosis-associated tyrosine kinase). | ||
Latest revision as of 05:59, 9 February 2022
Kinase Classification: Group TK: Family Lmr
An unusual and poorly-studied family of receptor tyrosine kinases. Most Lmr kinases are anchored in the membrane but have little or no extracellular region. They have a juxtamembrane kinase domain and a long, poorly conserved, C-terminal tail (the symbol Lmr, coined at Sugen, refers to the long tails of Lemurs). Vertebrates have three Lmr kinases (LMTK1-3), with one Lmr in many metazoans, though the family has been lost from both insects and nematodes. Lmr1 is the best studied member, also known as AATYK (Apoptosis-associated tyrosine kinase).
Evolution
Domain Structure
Functions
References
- Ahier A, Rondard P, Gouignard N, Khayath N, Huang S, Trolet J, Donoghue DJ, Gauthier M, Pin JP, and Dissous C. A new family of receptor tyrosine kinases with a venus flytrap binding domain in insects and other invertebrates activated by aminoacids. PLoS One. 2009 May 21;4(5):e5651. DOI:10.1371/journal.pone.0005651 |
