Difference between revisions of "Kinase Family MAPK"
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====[[Kinase_Subfamily_ERK1|Subfamily ERK1]]==== | ====[[Kinase_Subfamily_ERK1|Subfamily ERK1]]==== | ||
| − | The major | + | The major MAPK subfamily that transduces cell growth signals. |
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====[[Kinase_Subfamily_ERK3|Subfamily ERK3]]==== | ====[[Kinase_Subfamily_ERK3|Subfamily ERK3]]==== | ||
Poorly studied animal-specific family downstream of PAK kinases and possibly involved in cell cycle | Poorly studied animal-specific family downstream of PAK kinases and possibly involved in cell cycle | ||
Revision as of 21:56, 29 August 2023
Kinase Classification: Group CMGC: Family MAPK
The MAPKs (Mitogen Activated Protein Kinase) are the final kinases of the MAPK cascade, which relay signals from the cell surface for growth, stress and other responses. The best-known MAPKs include Erk, which relays growth signals from the ras/raf pathway and receptor kinases, and the JNK and p38 subfamilies, which relay various stress signals.
Most MAPKs have a specific TxY motif in their activation loop, in which both the T and Y are phosphorylated by MEK (MAP2K) kinases in order to activate them. Erk3 (~SeG) and nmo (TxE) are variants that lack the Y.
The MAPK family has the following subfamilies:
Subfamily ERK1
The major MAPK subfamily that transduces cell growth signals. .
Subfamily ERK3
Poorly studied animal-specific family downstream of PAK kinases and possibly involved in cell cycle
Subfamily ERK5
The MEKK2-MEK5-ERK5 pathway is found in holozoa and transduces mechanical stress and other signals
Subfamily JNK
JNK and p38 are the major stress-activated MAPK pathways.
Subfamily p38
JNK and p38 are the major stress-activated MAPK pathways.
