Kinase Family PKC

Kinase Classification: Group AGC: Family PKC

The Protein Kinase C family are second messengers activated by calcium, lipids and DAG. Four major subfamilies are found throughout metazoa, with different accessory domains and cofactor requirements.

Subfamily PKCa

Classical PKCs, activated by Ca2+, DAG and lipids, represented in human by PKC alpha, beta and gamma (PKCα, PKCβ, PKCγ) forms. PKCa members have twin DAG-binding C1 domains, followed by a C2 Ca/phospholipid-binding domain and a Kinase domain.

Subfamily PKCd

Novel PKCs that are Ca2+-independent, including human PKC delta and theta (PKCd/δ, PKCt/θ) Have a specialized C2 domain first, followed by twin C1 domains and then the Kinase domain

Subfamily PKCh

Another subfamily of novel PKCs, including human PKC epsilon (PKCe/ε) and eta (PKCh/η) Like PKCd, PKCh have a specialized C2 domain first, followed by twin C1 domains and then the Kinase domain

Subfamily PKCi

These are the atypical PKCs activated by phosphatidyl serine, with human members iota and zeta (PKCi/ι, PKCz/ζ).

Subfamily PKC-PKC-fun

Fungi typically have a single PKC homolog, with distinct functions and domain structure: triple HR1 domains followed by C2, then kinase domains. The HR1 domains bind the small GTPase Rho, downstream of cell wall stress receptors, and cause activation of a divergent MAPK cascade.

Gerard 01:45, 12 April 2018 (UTC)