Kinase Family PKC

Kinase Classification: Group AGC: Family PKC

The Protein Kinase C family are second messengers activated by calcium, lipids and DAG. Four major subfamilies are found throughout metazoa, with different accessory domains and cofactor requirements.

Subfamily PKCa

Classical PKCs, activated by Ca2+, DAG and lipids, represented in human by PKC alpha, beta and gamma forms

Subfamily PKCd

Novel PKCs that are Ca2+-independent, including human PKC delta and theta (PKCd, PKCt)

Subfamily PKCh

Another subfamily of novel PKCs, including human PKC epsilon (PKCe) and eta (PKCh)

Subfamily PKCi

These are the atypical PKCs activated by phosphatidyl serine, with human members iota and zeta (PKCi, PKCz).

Gerard 01:45, 12 April 2018 (UTC)