Difference between revisions of "Kinase Family RSKR"
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[[kinase classification|Kinase Classification]]: [[Kinase_Group_AGC|Group AGC]]: [[Kinase_Family_RSKR|Kinase Family RSKR]] | [[kinase classification|Kinase Classification]]: [[Kinase_Group_AGC|Group AGC]]: [[Kinase_Family_RSKR|Kinase Family RSKR]] | ||
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RSKR are '''RSK'''-'''R'''elated kinases, first named in the human <cite>Manning1</cite> and Drosophila<cite>Manning2</cite> kinome papers. The family is closely related to RSK and RSKL families, and is found only in bilateral animals. All have a central kinase domain with weakly conserved flanking regions. The human RSKR, SgK494 is uncharacterized, and the Drosophila homolog Pk17E has only been characterized as part of large-scale screens, making this one of the more mysterious of kinase families. | RSKR are '''RSK'''-'''R'''elated kinases, first named in the human <cite>Manning1</cite> and Drosophila<cite>Manning2</cite> kinome papers. The family is closely related to RSK and RSKL families, and is found only in bilateral animals. All have a central kinase domain with weakly conserved flanking regions. The human RSKR, SgK494 is uncharacterized, and the Drosophila homolog Pk17E has only been characterized as part of large-scale screens, making this one of the more mysterious of kinase families. | ||
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#Manning1 pmid=12471243 | #Manning1 pmid=12471243 | ||
#Manning2 pmid=12368087 | #Manning2 pmid=12368087 | ||
</biblio> | </biblio> | ||
Latest revision as of 04:41, 5 May 2014
Kinase Classification: Group AGC: Kinase Family RSKR
RSKR are RSK-Related kinases, first named in the human [1] and Drosophila[2] kinome papers. The family is closely related to RSK and RSKL families, and is found only in bilateral animals. All have a central kinase domain with weakly conserved flanking regions. The human RSKR, SgK494 is uncharacterized, and the Drosophila homolog Pk17E has only been characterized as part of large-scale screens, making this one of the more mysterious of kinase families.
References
- Manning G, Whyte DB, Martinez R, Hunter T, and Sudarsanam S. The protein kinase complement of the human genome. Science. 2002 Dec 6;298(5600):1912-34. DOI:10.1126/science.1075762 |
- Manning G, Plowman GD, Hunter T, and Sudarsanam S. Evolution of protein kinase signaling from yeast to man. Trends Biochem Sci. 2002 Oct;27(10):514-20. DOI:10.1016/s0968-0004(02)02179-5 |
