Difference between revisions of "Kinase Family STE7"
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STE7 (MAPKK, MAP2K, MEK) kinases are part of the MAPK signaling cascades: they are activated by [[Kinase_Family_STE11|STE11]] (MAP3K, MAPKKK) and phosphorylate [[Kinase_Family_MAPK|MAPK]] kinases. They are typically dual-specificity kinases, and phosphorylate a conserved TxY motif on MAPK. | STE7 (MAPKK, MAP2K, MEK) kinases are part of the MAPK signaling cascades: they are activated by [[Kinase_Family_STE11|STE11]] (MAP3K, MAPKKK) and phosphorylate [[Kinase_Family_MAPK|MAPK]] kinases. They are typically dual-specificity kinases, and phosphorylate a conserved TxY motif on MAPK. | ||
| − | + | The STE7 family has the following subfamilies: | |
| − | + | ||
| − | [[ | + | ====[[Kinase_Subfamily_MEK1|MEK1]]==== |
| − | [[ | + | ====[[Kinase_Subfamily_MEK3|MEK3]]==== |
| − | [[ | + | ====[[Kinase_Subfamily_MEK4|MEK4]]==== |
| − | [[Kinase_Subfamily_MEK7|MEK7]] | + | ====[[Kinase_Subfamily_MEK5|MEK5]]==== |
| + | |||
| + | ====[[Kinase_Subfamily_MEK7|MEK7]]==== | ||
====Evolution==== | ====Evolution==== | ||
STE11 kinases are found in almost all eukaryotes, with Plasmodium being a notable exception. | STE11 kinases are found in almost all eukaryotes, with Plasmodium being a notable exception. | ||
Latest revision as of 08:01, 16 January 2022
Kinase Classification: Group STE: Family STE7
STE7 (MAPKK, MAP2K, MEK) kinases are part of the MAPK signaling cascades: they are activated by STE11 (MAP3K, MAPKKK) and phosphorylate MAPK kinases. They are typically dual-specificity kinases, and phosphorylate a conserved TxY motif on MAPK.
The STE7 family has the following subfamilies:
MEK1
MEK3
MEK4
MEK5
MEK7
Evolution
STE11 kinases are found in almost all eukaryotes, with Plasmodium being a notable exception.
