Kinase Family STE7

Kinase Classification: Group STE: Family STE7

STE7 (MAPKK, MAP2K, MEK) kinases are part of the MAPK signaling cascades: they are activated by STE11 (MAP3K, MAPKKK) and phosphorylate MAPK kinases. They are typically dual-specificity kinases, and phosphorylate a conserved TxY motif on MAPK.

The STE7 family has the following subfamilies:

Evolution

STE11 kinases are found in almost all eukaryotes, with Plasmodium being a notable exception.