Kinase Group RGC

Kinase Classification: RGC Group

RGCs are Receptor Guanylate Cyclases that have an unusual structure: they are single-pass transmembrane receptors that have an active guanylate cyclase domain and a catlytically inactive kinase domain on the intracellular side. The guanylate cyclase domain makes the second messenger cGMP, and the kinase domain may have a regulatory role and may bind ATP.

Evolution

RGCs are seen only in animals and choanoflagellates.

Families

No families have yet been defined within the RGC group, though several conserved classes are clear.