Kinase Subfamily DAPK

Kinase Classification: Group CAMK: Family DAPK: Subfamily DAPK

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Domain Structure

DAPK kinases have an N-terminal kinase domain and a variable C terminal extension. The ancestral state, found in human DAPK1 and nematode K12C11.4 has ankyrin repeat region followed by ROC and COR domain and a death domain. Vertebrate DAPK2 and DAPK3, and the sole Drosophila homolog, CD1760, lack these additional domains.