Kinase Subfamily Unc89
From WikiKinome
Kinase Classification: Group CAMK: Family MLCK: Subfamily Unc89
DRAFT!
The Unc89 subfamily is named after the C. elegans unc-89 kinase, and also includes Drosophila unc-89 and the vertebrate proteins obscurin (obscn) and Speg. They are generally extremely long proteins with arrays of immunoglobulin domains, twin kinase domains and at least one RhoGEF guanine nucleotide exchange factor domain.
From 2002 to 2010, Unc89 proteins were classified with the Trio subfamily as a distinct family. They have now been merged into the MLCK family, along with the classical MLCKs and Titin. Unc89 and Trio subfamilies share the presence of RhoGEF and PH domains, though their kinase domains are not particularly similar to each other.
