PKL
From WikiKinome
Kinase Glossary: PKL
PKL stands for Protein Kinase-Like. It refers to the protein structure fold shared by most protein kinases. These also share a similar catalytic mechanism. A variety of PKL classes have been found in prokaryotes and eukaryotes [1], and their structural and sequence relationships explored [2]. All catalytically active PKLs act as kinases, though not all are protein kinases. For instance, PI3Ks phosphorylate phosphoinositides, and CAKs phosphorylate various small molecules. ePKs are a major class of protein-specific kinases within PKL and account for the majority of human kinases.
See also: Protein Kinase Evolution
References
- Kannan N, Taylor SS, Zhai Y, Venter JC, and Manning G. Structural and functional diversity of the microbial kinome. PLoS Biol. 2007 Mar;5(3):e17. DOI:10.1371/journal.pbio.0050017 |
- Scheeff ED and Bourne PE. Structural evolution of the protein kinase-like superfamily. PLoS Comput Biol. 2005 Oct;1(5):e49. DOI:10.1371/journal.pcbi.0010049 |
