Bub1_Dmel FEVSKMIGKGAYGSVYVGKH---------------------------LKSGKKVALKQER
CG14030_Dmel FSIDKEVGRGSYGSVYKATD---------------------------SRTGNVVALKYQK
BUBR1_Mmus LEIGKEIELGPEDYVIKQEHLTCDD--------------YRLFWVAPRSSAELTMIKASS
BUB1_Mmus VYVNHLLGEGAFAQVFEAIHGDV-----------------R-----NAKSEQKCILKVQR
R06C7.8_Cele LHIQTLIGQGGYAKVYRAVT----------------------------DDQRTVAVKYEV
BUB1_Scer YCIRGELGEGGYATVYLAE----------------------------SSQGHLRALKVEK
BUB1_Hsap VYVHHLLGEGAFAQVYEATQGDL-----------------N-----DAKNKQKFVLKVQK
BUBR1_Hsap LEIEKEIELGNEDYCIKREYLICED--------------YKLFWVAPRNSAELTVIKVSS
Bub1_Ddis -----------------------------------------------TSEDSWLSCKVQD
BUB1_Spur YSVMEKVGEGAFATIYLAACLDALD--------------MT----DLDRDFRRVALKVQH
CC1G_07078_Ccin FMLSEKLGEGGFGSVYKARDLGMRTGDDDDDDDDDDFDDFD----DDEENASMVAIKVVK
AqueK151_Aque CSVIGKLAKGGFASVYNVK----------------------------MMNGSTKALKIQN
BUB_a-2_Smoe ------------------------------------------------------------
BUB_a-1_Smoe ------------------------------------------------------------
Bub1_Dmel PTNYWEFYICLEIHSRLTSE----QMIPSYAHIDYALVGNNSSVYISE-FSDYGSLIGVC
CG14030_Dmel PPNTWEIYICDQVLKRIKEP----EVLPGVMDISTAIIAPNASLIATE-FSPFGSLLDIN
BUBR1_Mmus QPIPWDFYINLKLKERLNEDYDQ---------LCSCCQYQDGHVVWYQ-YINCSTLQNLL
BUB1_Mmus PANSWEFYIGMQLMERLKPE-----VHHMFIKFYSAHLFKNGSILVGE-LYSYGTLLNVI
R06C7.8_Cele PSCSWEVYICDQMRNRLKDRGLELMAKCCIMEVMDAYVYSTASLLVNQ-YHEYGTLLEYA
BUB1_Scer PASVWEYYIMSQVEFRLRKS----TILKSIINASALHLFLDESYLVLN-YASQGTVLDLI
BUB1_Hsap PANPWEFYIGTQLMERLKPS-----MQHMFMKFYSAHLFQNGSVLVGE-LYSYGTLLNAI
BUBR1_Hsap QPVPWDFYINLKLKERLNEDFDH---------FCSCYQYQDGCIVWHQ-YINCFTLQDLL
Bub1_Ddis PPSIWEFYIGNQIHQRLQERSLTI-SNSKFPTIHSLYYYTDKSIMLMDHTIDQGTLDDVV
BUB1_Spur PPCPWEMYVIKELHARLSRLPSQIDVRPSIMTAECAHIYQDKSCMVTE-YKSKGTLLDLI
CC1G_07078_Ccin PRNLWEYHALRRLHSALPAN-----LRRSLVLPHGLYAYGDESFLILD-LCTQGMLLDIV
AqueK151_Aque PPCLWEVAIIEELHKRLKANDLLK-FSQCFMSVDAVHLYTNSSIIAYN-YYPHGTLLDLV
BUB_a-2_Smoe -------------------------------------------------YGQHGTLQDVV
BUB_a-1_Smoe -------------------------------------------------YGQHGTLQDVV
:
Bub1_Dmel NKVKSVT----NRNMDEYVVMHLSCQMLDIVDHLHAMGIIHADIKPDNFLLMKPIC----
CG14030_Dmel NKIRQAT----TKVMHESLVMHFSAQICNIVDHLHRQHIIHADIKPDNFLLMRVPN----
BUBR1_Mmus QHS---------EFVTHEIIVLIIYNLLTIVEKLHRAEIVHGDLSPRSLILRNRIHDPYD
BUB1_Mmus NLYKNTS----EKVMPQALVLTFAIRMLYMVEQVHSCEIIHGDIKPDNFILGHRFLEQAD
R06C7.8_Cele NNMKDPN---------WHITCFLITQMARVVKEVHASKIIHGDIKPDNFMITRKIDDKWG
BUB1_Scer NLQREKAID-GNGIMDEYLCMFITVELMKVLEKIHEVGIIHGDLKPDNCMIRLEKPG-EP
BUB1_Hsap NLYKNTP----EKVMPQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDD
BUBR1_Hsap QHS---------EYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYD
Bub1_Ddis SST--NG-----VPMEEPLAMFHCIELLKMIEDLHLVGIIHGNICANNLHFLFGQT-S-D
BUB1_Spur NKVKAVN----KKDLSEDWVLFFAIEILQTVEYMHRCKIIHGDIKPDNFLINTDNDENFT
CC1G_07078_Ccin NNAASAGISQAGACLDELLVIFFTIELLRLVEGMHSAGFIHGDLKIDNCLLRLEDVPGGA
AqueK151_Aque NTCRTTS-----KKLTEAVLLYYTTEICQLVEALHCCGIIHADIKPDNIMLRDIRP-I--
BUB_a-2_Smoe NAYLAHS-----LKMDELLCMYYTIEMLRMLEVLHGVGIIHADFKPDNLLIRNES-----
BUB_a-1_Smoe NAYLAHS-----LKMDELLCMYYTIEMLRMLEVLHGVGIIHADFKPDNLLIRNDRYLLVS
. .: :. :* ::*.:: :
Bub1_Dmel ------------ADPNEVSLQLIDFGVSIDMKLFPDN--QTFNYVHHDDLF----K----
CG14030_Dmel ------------VDSPLPSLRLIDFGCAIDMTLFPDGEKTKFRKVVQTDGF----T----
BUBR1_Mmus -----------YVNKDDHAVRIMDFSYSVDLRVQLDA--FAYSGFRTAQIL----E----
BUB1_Mmus ------------E-DLATGLALIDLGQSIDMKLFPKG--TVFTGKCETSGF----Q----
R06C7.8_Cele KD--------ALMSNDSFVIKIIDWGRAIDMMPL-KN--QRFKGRAGTEAF----D----
BUB1_Scer --LGAHYMRNGEDGWENKGIYLIDFGRSFDMTLLPPG--TKFKSNWKADQQ----D----
BUB1_Hsap ------------EDDLSAGLALIDLGQSIDMKLFPKG--TIFTAKCETSGF----Q----
BUBR1_Hsap ------------CNKNNQALKIVDFSYSVDLRVQLDV--FTLSGFRTVQIL----E----
Bub1_Ddis WPDW--TAGECKGAWKSKGFTLTDFSRSIDTTIYSQD--ARYQSPIELLPIGTPLEWLKI
BUB1_Spur -----------CSQEPSSLVKLIDFGRSIDMTLFPEG--TVFTAKCKTSGF----N----
CC1G_07078_Ccin AAWSSLYQPSGEGGWQYKGLKVIDFGRTIDTRLFPAD--QQFIAEWPTDER----D----
AqueK151_Aque -TDY--------TSIRGRGVCLLDFGRAIDAQSFPRG--TQFVGSCGTDSF----Q----
BUB_a-2_Smoe --RG--------LCLALQGLCLIDWGRSIDMRLFPEG--TEFLADSKTSAF----R----
BUB_a-1_Smoe VPRG--------LCLALQGLCLIDWGRSIDMRLFPEG--TEFFADSKTSAF----R----
. : * . :.*
Bub1_Dmel CIEMRTGRPWTYQLDLYGLVSVMH-VLLFGRY-MEV------VQRSPSTIWMP-KTNVP-
CG14030_Dmel CIEMQEGRSWSYETDLFCIAATVH-VMLFGDY-MQP------QKK--GSSWEI-RQKLP-
BUBR1_Mmus GQKILANCSSPYHVDLLGIADLAH-LLLFKEH-LHV------FWD--GLLWKL-SQSTS-
BUB1_Mmus CPEMLSNKPWNYQIDYFGVAATIY-CMLFGSY-MKV------KNE--GGVWKP-EGLFR-
R06C7.8_Cele CPEMVDGRSWTYQADYFGFAATMA-VVVAGKY-AQL------TGASV-GDYSL-NVDIKR
BUB1_Scer CWEMRAGKPWSYEADYYGLAGVIH-SMLFGKF-IET-----IQLQNG--RCKL-KNPFK-
BUB1_Hsap CVEMLSNKPWNYQIDYFGVAATVY-CMLFGTY-MKV------KNE--GGECKP-EGLFR-
BUBR1_Hsap GQKILANCSSPYQVDLFGIADLAH-LLLFKEH-LQV------FWD--GSFWKL-SQNIS-
Bub1_Ddis NQSSTTNVGWSYNLDYLGICKVMFHILTCGKEELKL------SLSQQTGKLEIINQSII-
BUB1_Spur CTEMQSDQPWTYQVDYYGIAGTVH-CLMFGKY-MKV------FRE--GGIWKM-TSKVP-
CC1G_07078_Ccin CFEIREGRPWTYQTDYFGLAGIIY-CMLFGKY-ITSSAVVQVQGQHGETRYKI-GTPLK-
AqueK151_Aque CIQMLNNEPWSWHTDLHCIAGTVH-VLLHLDY-MEV------IKNAMTGEYVP-SKSLP-
BUB_a-2_Smoe CIEMMEERPWTYQVDGYGLCCIVH-CMLH-------------------------------
BUB_a-1_Smoe CIEMVEERPWTYQVDGYGLCCIVH-CMLH-------------------------------
. :. * . :
Bub1_Dmel R---YFQ-RTMWENIFRTLLNIRDCR--TMPNLQQL------------------------
CG14030_Dmel R---YLK-KHVWTKFFGDLLNMQA-D--KLPALHEMRLIF---E----------------
BUBR1_Mmus E---LKD-SELWNKFFVRILNASDKS--TVSVLGEL------------------------
BUB1_Mmus R---LPH-LDMWEEFFHIMLNIPDCH--NLPSLDFL------------------------
R06C7.8_Cele R---NIL-RDACYDVINRFLNIPSCD--SLPDWNILIKSF--------------------
BUB1_Scer R---YWK-KEIWGVIFDLLLNSGQASNQALPMTEKIVEIRNLIESHLEQHAENHLRNVIL
BUB1_Hsap R---LPH-LDMWNEFFHVMLNIPDCH--HLPSLDLL------------------------
BUBR1_Hsap E---LKD-GELWNKFFVRILNANDEA--TVSVLGEL------------------------
Bub1_Ddis QKDSFSELDTLWLPFLTTLLNHNGENGN--QQTTTTTYIL---K----------------
BUB1_Spur R---CAK-V-DWKGFFHTLLNVPSCDPSDLPHLGDL------------------------
CC1G_07078_Ccin R---YWQ-ADLWNRLFDILL----------------------------------------
AqueK151_Aque R---NYD-RVLWMKFFTDLLNWSGEGQ---PDMKALTQPL---S----------------
BUB_a-2_Smoe ------------------------------------------------------------
BUB_a-1_Smoe ------------------------------------------------------------
Bub1_Dmel ---------------RTQL
CG14030_Dmel ----E-EAYRMDSELQKQI
BUBR1_Mmus -----------------AA
BUB1_Mmus ---------------RQNM
R06C7.8_Cele -------S-EI--WNEKFE
BUB1_Scer SIEEELSHFQYKGKPSRRF
BUB1_Hsap ---------------RQKL
BUBR1_Hsap -----------------AA
Bub1_Ddis ----Q-QR-NLFENYLQSN
BUB1_Spur ---------------RRQL
CC1G_07078_Ccin ------------------N
AqueK151_Aque ----R-KL-SL--NVSHLK
BUB_a-2_Smoe ------------------G
BUB_a-1_Smoe ------------------G