Protein (view, download) , Domain (view, download)
Bub1_Dmel        MDF-------------------DNA--------KENIQPLASGRN-----VS-LLQAS-L
CG14030_Dmel     MAMHS---------------YM--------------RQGSGSGGG-----AG-AVAAG--
BUBR1_Mmus       MAEASE-------AMCLEGAEWELS--------KENIQPLRHGRV-----MS-TLQGA-L
BUB1_Mmus        MDN-------------------L-------------------------------------
R06C7.8_Cele     MSHIRVAF--------------------------A---PLDTNPS-----TC-GLETF-A
BUB1_Scer        MNL-------------------DLGSTVRGYESDKDTFPQSKG----------------V
BUB1_Hsap        MDT-------------------P-------------------------------------
BUBR1_Hsap       MAAVKKEGGALSEAMSLEGDEWELS--------KENVQPLRQGRI-----MS-TLQGA-L
Bub1_Ddis        MSSLS---------------DWENT--------KENIVPLKTGRD-----PT-KLALF--
BUB1_Spur        MERDQDMKS---------IDEWELS--------KENVLPLKQGRK-----MT-NLTAA-L
CC1G_03571_Ccin  MISADDVFQ-ESEPVVVDCDLLEAA--------KENVQPLATGRR-----VT-ALSTV-L
CC1G_07078_Ccin  MSSSTLS-----------------------------------------------------
AqueK151_Aque    MHQYTLTH--------------------------THTHTLILYTITMYLSLS-LLSHSCN
BUB_a-2_Smoe     ------------------------------------------------------------
BUB_b-2_Smoe     MEW-------------------ELS--------KENVQPLRKGRK-----NVDLLNQG-L
BUB_b-1_Smoe     MEW-------------------ELS--------KENVQPLRKGRK-----NVDLLNQG-L
BUB_a-1_Smoe     ------------------------------------------------------------


Bub1_Dmel        -S-QDSTH--GQELLAQRKQM----EEEV--RTYKGADPL--------------------
CG14030_Dmel     -APPLASPDEMHGFLNDKQAW----EHAI--SLYQGPDPL--------------------
BUBR1_Mmus       -AKQESAG--HTALQQQKRAF----ESEI--RFYSGDDPL--------------------
BUB1_Mmus        --------------ENVFRMF----EAHM--QSYTGNDPL--------------------
R06C7.8_Cele     --TQIETL--SQM--------------------------------------M--------
BUB1_Scer        SSSQKE-Q--HSQLNQTKIAY----EQRLLNDLEDMDDPL--------------------
BUB1_Hsap        --------------ENVLQML----EAHM--QSYKGNDPL--------------------
BUBR1_Hsap       -A-QESAC--NNTLQQQKRAF----EYEI--RFYTGNDPL--------------------
Bub1_Ddis        -AKQTNQS--DEELEKEKQKF----EIII--NEYQGEDPI--------------------
BUB1_Spur        -QPQNFDR--QQQLILQRQGF----ETEL--RTYTGDDPL--------------------
CC1G_03571_Ccin  -ATPAAQR--DAKLSATRNRLRINVELAL--E-DEDGDPL--------------------
CC1G_07078_Ccin  ------AA--DRERYRE--KYRKKL----AKALTEDDDPL--------------------
AqueK151_Aque    --TNFEFL--EKI-------YTSKL--ND--QDYFYQVPSKQLIMYPKHLVYPDGVDAKR
BUB_a-2_Smoe     ------------------------------------------------------------
BUB_b-2_Smoe     KAKHKSPA--RSVLIEQRRIL----LEKI--DDYVGDDPL--------------------
BUB_b-1_Smoe     KAKHESPA--RSVLIEQRRIL----LEKI--DDYVGDDPL--------------------
BUB_a-1_Smoe     ------------------------------------------------------------


Bub1_Dmel        ------------------------GAWYTFICWIEQSYPAGGS-GS---GLQ---TVLHQ
CG14030_Dmel     ------------------------DHWYNYICWYEN-HAQSDP-EL---KYR---ETLER
BUBR1_Mmus       ------------------------DVWDRYINWTEQNYPQGGK-ES---NMS---ALVER
BUB1_Mmus        ------------------------GEWESFIKWVEENFPDN---KE---YLM---TLLEH
R06C7.8_Cele     ------------------------------------------TAE----EMK---AELYD
BUB1_Scer        ------------------------DLFLDYMIWISTSYIEVDS-ESGQEVLR---STMER
BUB1_Hsap        ------------------------GEWERYIQWVEENFPEN---KE---YLI---TLLEH
BUBR1_Hsap       ------------------------DVWDRYISWTEQNYPQGGK-ES---NMS---TLLER
Bub1_Ddis        ------------------------DNWLKYIKWVQQSYPGGNM-KE---QLI---VLLER
BUB1_Spur        ------------------------DSWIRYIQWTEQNFPQGGK-DS---HLG---VLMQK
CC1G_03571_Ccin  ------------------------EAYCRLVYWTMENYPQGHSAES---GLL---ELLEE
CC1G_07078_Ccin  ------------------------ATYNQFVQWTVKHYGEKDR-SS---GLL---ELLKD
AqueK151_Aque    DVCLEELRASRTRYCPSPSPDCDMDMTEAYCGNITVNVPVVASME----KGREVLHLMEH
BUB_a-2_Smoe     -------------------------------------------------ELC---PLLEF
BUB_b-2_Smoe     ------------------------EPWIRCIEWTKEAFPSGGS-QS---GIL---PMLEL
BUB_b-1_Smoe     ------------------------EPWIRCIEWTKEAFPSGGS-QS---GIL---PMLEL
BUB_a-1_Smoe     -------------------------------------------------ELC---PLLEF
                                                                          :

Bub1_Dmel        CLTKFEDD------ERYRQDKR-LIKLFIKFMEK---------------------QKDKI
CG14030_Dmel     CLTVYEHN------DYYRQDVR-LVRLWLKYIAM---------------------QTDPL
BUBR1_Mmus       AIEALQGE------TRYYNDPR-FLSLWIKLGHL---------------------CNEPL
BUB1_Mmus        LMKEFLHK------KNYHNDSR-FINYCLKFAEY---------------------NSDRH
R06C7.8_Cele     CVRRILREQKF---DQIRENEA-MLRLYKVMGRS-------------------STNLKGR
BUB1_Scer        CLIYIQDM------ETYRNDPR-FLKIWIWYINLFL----------------SNNFHESE
BUB1_Hsap        LMKEFLDK------KKYHNDPR-FISYCLKFAEY---------------------NSDLH
BUBR1_Hsap       AVEALQGE------KRYYSDPR-FLNLWLKLGRL---------------------CNEPL
Bub1_Ddis        CTRLFLST------EKYKNDPR-YLRIWITYADM---------------------CRDPI
BUB1_Spur        CLIQFKND------DLYKQDIR-YVSIWLKMAQY---------------------DSESL
CC1G_03571_Ccin  ATRVLKDHNG----GVYRGDMK-YLKLWLIYASY---------------------VERPT
CC1G_07078_Ccin  ATNQFKDD------PMYKNDLR-YLKMWALYARQL-------------------ERSQAA
AqueK151_Aque    KPEKLLVLSKEEPGGNMTRELQEKENLPVSLNQF-------------------DFTPSAS
BUB_a-2_Smoe     CTKAFLDD------PRYREDLR-YLRIWLRYVSLLLCLVLLYSYFPSLQPLQADCCADPL
BUB_b-2_Smoe     CLRTFCDD------SKYKSDLR-YLKLWLDYADR---------------------CTHPR
BUB_b-1_Smoe     CLRTFCDD------SKYKSDLR-YLKLWLDYADR---------------------CTHPR
BUB_a-1_Smoe     CTKAFLDD------PRYREDLR-YLRIWLRYVSLLLCLVLLYSYFPSLQPLQADCCADPL
                                    :

Bub1_Dmel        EFYQQ--MYNNG-IGTMLADFYIAWAYS----YDLSGNMRKADEIFRLGLECRAEPLEDL
CG14030_Dmel     HFYQV--LFQRG-TGRQVAAFYIGWAAY----YESREEYKDAEAVFNLAFQEKAQSTSEL
BUBR1_Mmus       DMYSY--LQSQG-IGVSLAQFYISWAEE----YEARENFKKADIIFQEGIERKAEPLDRL
BUB1_Mmus        QFFEF--LYNQG-IGTKSSYIYMSWAGH----LEAQGELQHASAIFQTGIHNEAEPKELL
R06C7.8_Cele     GIYEQ--LFKKD-HFTGSLKFYLQWAEE----CGKDQMLEEFKDVLKLARDRLSERIEMT
BUB1_Scer        NTFKY--MFNKG-IGTKLSLFYEEFSKL----LENAQFFLEAKVLLELGAENNCRPYNRL
BUB1_Hsap        QFFEF--LYNHG-IGTLSSPLYIAWAGH----LEAQGELQHASAVLQRGIQNQAEPREFL
BUBR1_Hsap       DMYSY--LHNQG-IGVSLAQFYISWAEE----YEARENFRKADAIFQEGIQQKAEPLERL
Bub1_Ddis        EVFSF--LEVQR-IGFYLSLLYEARAIV----YENKGNYEQADKSFKQGIERKAQPIERL
BUB1_Spur        EIFKF--MQANQ-TGTKLTLFYEAWAWE----LEQVGNTKRADAIYKEGLANNAQPRERL
CC1G_03571_Ccin  IIYRF--LLAND-IGIGFALLYEEHAAV----LERDGRKQEADEIYALGIARKAEPLDHL
CC1G_07078_Ccin  KIYAF--LVEKE-IGTTYSALYEDYANL----LEREGRRSEAEKIYLQGIEKQVRPLERL
AqueK151_Aque    ESYSHQYSYNGASFSMKGALSFSESDSLVSSACQSEEEAKMFKEKTVLKQERHSDQVH--
BUB_a-2_Smoe     HIFEL--LEAKR-IGQTHSLFYEAYAMI----LELRGDITKANQIYELGISRHAQPVEQL
BUB_b-2_Smoe     DIYVF--LEVND-IGQTYAQFYEAYASY----LERCKNLSKANEVFQIGIARAAEPVEEL
BUB_b-1_Smoe     DIYVF--LEVND-IGQTYAQFYEAYASY----LERCKNLSKANEVFQIGIAREAEPVEEL
BUB_a-1_Smoe     HIFEL--LEAKR-IGQTHSLFYEAYAMI----LELRGDITKANQIYELGISRHAQPVEQL
                   :                  :                    .

Bub1_Dmel        KEAHHHFGYTVGQRMLYSTGE----EANAVN---------Q-ELNERRLALQ-SLHGRRQ
CG14030_Dmel     QHAHTKFAYARSLFYQRQQQQ---QQQ-QQ----------QHQQHPPQDALQ-QLTNYAQ
BUBR1_Mmus       QSQHRQFQSRVSRQAFLALGN---EE-EEA----------LEPSEPQRSSLA-ELKSRGK
BUB1_Mmus        QQQYRLFQARLTGIHLPAQAT----TSEPLH---------SAQILN--------------
R06C7.8_Cele     -AIESGFRDLVD---EYFNGESGDMFTRPDETM-DLFRFNAGSKKKRRSSVC-FLQHN--
BUB1_Scer        LRSLSNYEDRLREMNIVENQN-----SVPDS---------RERLKG-----------RLI
BUB1_Hsap        QQQYRLFQTRLTETHLPAQAR----TSEPLH---------NVQVLN--------------
BUBR1_Hsap       QSQHRQFQARVSRQTLLALEK---EEEEEV----------FESSVPQRSTLA-ELKSKGK
Bub1_Ddis        QQKHLDFERRLIARLKHQQQH---QQL-QQ----------QQQQQNDQLEQQ-QLDENGN
BUB1_Spur        ERALIEFQSRVGRATVQQMQE---GTMNPTS---------TASAEDQRATLG-DLRARG-
CC1G_03571_Ccin  ESRYQDFQKRMISTFTAPAPE----PARTTQ-----------AAQPKRQALA-TTSKIPT
CC1G_07078_Ccin  KTRYKEFQARASQAAAQSN-R-----SIPSG--------------SRSASLA-SIASAPS
AqueK151_Aque    ----QSLQYTHSSESLYANNKLPCPKTKPVSQLSRTLETDIGTSSVPISSIAVSQEGRLD
BUB_a-2_Smoe     EKMHASFLKRKFKTSRPSE-----------------------------------------
BUB_b-2_Smoe     KIKYKSFLERTLRKPKPDA------EEDT-------------------------------
BUB_b-1_Smoe     KIKYKSFLERTLRKPKPDA------EEDT-------------------------------
BUB_a-1_Smoe     EKMHASFLKRKFKTSRPSE-----------------------------------------


Bub1_Dmel        -QISNSITVGSIRTGAAVK-------SGLPGVVQVEP----------STTTSRRNVGRNV
CG14030_Dmel     QQMPQ---SYN-----------------Q-----HRP----------QPYQQN-------
BUBR1_Mmus       -KMAR---APISRVGGALK--APGQ--S-RGFLNAVP----------QPVHGN----RRI
BUB1_Mmus        -----------------------------------------------QVMMTNSSPEKNS
R06C7.8_Cele     --------VPINNSGKAAF--GPKT--K-TDLRQ--------------------------
BUB1_Scer        -YRTAPFFI-----------------------RKFLT----------SSLM--TDDKENR
BUB1_Hsap        -----------------------------------------------QMITSKSNPGNNM
BUBR1_Hsap       -KTAR---APIIRVGGALK--APSQ--N-RGLQNPFP----------QQMQNN----SRI
Bub1_Ddis        TKLTR---SALGTISSSSV--HSERKSQQTKGLPLGNSTIDKKRKVGNDQKNN----LGF
BUB1_Spur        -KHQK---VGTNRTGAAMR--S-----S-RGGLPTAP----------APLQQRS---NQI
CC1G_03571_Ccin  -STSR---TGGTRIASSSR--N-----T-TVAAPTNM----------PPPSNRG----GF
CC1G_07078_Ccin  -TTSA-NLVSFNST-AA----------S-RYALMLAP----------TPP----------
AqueK151_Aque    -SF-----SVYNDSQVSINQPAAGQS-T-RPPLQVLP----------QE-KS-L---TSF
BUB_a-2_Smoe     ------------------------------------------------------------
BUB_b-2_Smoe     ------------------------------------------------------------
BUB_b-1_Smoe     ------------------------------------------------------------
BUB_a-1_Smoe     ------------------------------------------------------------


Bub1_Dmel        EVFNDENS-EGNIP----------------------ISNSE-TEV-KSSLRSIID-S--A
CG14030_Dmel     -VYQQYHP-QAQ-A-------------------HQAPQPHQP-----------A-----P
BUBR1_Mmus       TVFDENAD-TAS-R----------------------TELSK-PVAQ-PWMAPPV-----P
BUB1_Mmus        ACVPRS------QG----------------------SECS-----------GVAS-S--T
R06C7.8_Cele     -----ACI-DRP-NY---------------------------------------------
BUB1_Scer        ANLNSN------VG----------------------VGKSA-P--------NVYQDSIVV
BUB1_Hsap        ACISKN------QG----------------------SELS-----------GVIS-S--A
BUBR1_Hsap       TVFDENAD-EAS-T----------------------AELSK-PTVQ-PWIAPPM-----P
Bub1_Ddis        QIFDDEKG-GST-TNEVLTDSKFFGSSRKAAALMAAGQTQQTSQMKWDELEPEL-----N
BUB1_Spur        SIFCDDGA-QG-------------------------AAAAQ-PSGQWQHLPSRS-----E
CC1G_03571_Ccin  QIFVDPSGQNG-------------------------EAREG-GENGWHDLGTRK-----T
CC1G_07078_Ccin  ------------------------------------------------------------
AqueK151_Aque    SVYEEASI-NQP-SF----------------------KQSV-PSAR-P----P-------
BUB_a-2_Smoe     ------------------------------------------------------------
BUB_b-2_Smoe     ------------------------------------------------------------
BUB_b-1_Smoe     ------------------------------------------------------------
BUB_a-1_Smoe     ------------------------------------------------------------


Bub1_Dmel        CSQEN-IKEPVAWNKANAKRHK--HGKIFGSNASP--DLGFDIHVDEQ------------
CG14030_Dmel     QQQLP-PEQQVPYQTHY--QER-PRYEPH----------P--------------------
BUBR1_Mmus       RAKEN-ELQPGPWSTDRPAGRR-PHDNPASVTSIPSVLPSFTPYVEES------------
BUB1_Mmus        CDEKSNIREQRVIMIS--------------------------------------------
R06C7.8_Cele     ------------------------------------------------------------
BUB1_Scer        ADFKSET-ERLNLNSS--KQPS--NQRLKNGNKK------TSIYADQK------------
BUB1_Hsap        CDKESNM-ERRVITIS--------------------------------------------
BUBR1_Hsap       RAKEN-ELQAGPWNTGRSLEHR-PRGNTASLIAVPAVLPSFTPYVEET------------
Bub1_Ddis        KHKEN-TQLSQKWSDVKLLQKK-QKITTA----------GFQIYCDQDSLSNNNNGSNNN
BUB1_Spur        SQKEN-TSSAGQWAGQRLPQRNMPRMTFQEVSSY--SRPDFAVHVDEN------------
CC1G_03571_Ccin  RVKEN-VPETKKLVGTTIKQAGKTR-----------------------------------
CC1G_07078_Ccin  ------------------------------------------------------------
AqueK151_Aque    ------------------------------------------------------------
BUB_a-2_Smoe     ------------------------------------------------------------
BUB_b-2_Smoe     ------------------------------------------------------------
BUB_b-1_Smoe     ------------------------------------------------------------
BUB_a-1_Smoe     ------------------------------------------------------------


Bub1_Dmel        ----------------------------------AMPPITNYE-----------------
CG14030_Dmel     -----ATQSPTAIPPSQVQQQSHYAPVAESHYAPAQQSQLPPQQTTVPQLHAQQPQQQQN
BUBR1_Mmus       ----------------------------------AQQTVMTPC-----------------
BUB1_Mmus        ------------------------------------------------------------
R06C7.8_Cele     ------------------------------------------------------------
BUB1_Scer        ------------------------------------------------------------
BUB1_Hsap        ------------------------------------------------------------
BUBR1_Hsap       ----------------------------------ARQPVMTPC-----------------
Bub1_Ddis        NNNNNNENIPL-SPDK---------LRV---HSSKQQSKLEQI-----------------
BUB1_Spur        ----------------------------------ADQ-ITTPR-----------------
CC1G_03571_Ccin  ------------------------------------------------------------
CC1G_07078_Ccin  ------------------------------------------------------------
AqueK151_Aque    ------------------------------------------------------------
BUB_a-2_Smoe     ------------------------------------------------------------
BUB_b-2_Smoe     ------------------------------------------------------------
BUB_b-1_Smoe     ------------------------------------------------------------
BUB_a-1_Smoe     ------------------------------------------------------------


Bub1_Dmel        --------RRLEQP------FRFPTNFVAKNRPQE-PWVTPVTI-EDEPNASGLPCYNKC
CG14030_Dmel     GNGNPPPQQSPPVTNE-VAGLRLPRNFHAYGRNNHETWKPALTLEEPDDP-SRVCHYAKQ
BUBR1_Mmus       --------KIEPSINH-VLSTRKP-----GREEGDPLQRVQSHQQGCEEK-KEKMMYCKE
BUB1_Mmus        -------------------------------KSEC---SVSSS-VAPKPE-AQQVMYCKE
R06C7.8_Cele     ------------------------------------------------------------
BUB1_Scer        -------------------------------QSNN---PVYKLINTPGRK-PERIVFNFN
BUB1_Hsap        -------------------------------KSEY---SVHSS-LASKVDVEQVVMYCKE
BUBR1_Hsap       --------KIEPSINH-ILSTRKP-----GKEEGDPLQRVQSHQQASEEK-KEKMMYCKE
Bub1_Ddis        --------QNNPLANFPKVSTSNS-----SSSSSSSTNKSTSTTTVTTTK-NERVGYNKP
BUB1_Spur        --------KPLEMGFQ-VLSEKKH-----CK----PTNALHHITKDNVKD-NTRVMYCKH
CC1G_03571_Ccin  ------------------------------------------------------------
CC1G_07078_Ccin  -----------------------------------------------GKR-PEKLKFNMG
AqueK151_Aque    ------------------------------------------------------------
BUB_a-2_Smoe     ------------------------------------------------------------
BUB_b-2_Smoe     ------------------------------------------------------------
BUB_b-1_Smoe     ------------------------------------------------------------
BUB_a-1_Smoe     ------------------------------------------------------------


Bub1_Dmel        LLYPRP-NIEFSPEEYRAYSF------------LKHRNPQHPFIHRNDDWWGTGRVIR-G
CG14030_Dmel     LVYPPGAGVEYSPEEILARKF------------KQLMDQKAKP-S-------EPPEQEQ-
BUBR1_Mmus       KIYA-G-VGEFSFEEIRAEVF------------RKKLKERREA-E-------LLTSAK-K
BUB1_Mmus        KLIR-G-DSEFSFEELRAQKY------------NQRKKHEQWV-S-------EDRNYM-K
R06C7.8_Cele     --------HGISIEEFRFAKW------------KDTFGEDV------------DDDY---
BUB1_Scer        LIYPEN-DEEFNTEEILAMIKGLY---------KVQRRGKKHT-E-------DYTSDK-N
BUB1_Hsap        KLIR-G-ESEFSFEELRAQKY------------NQRRKHEQWV-N-------EDRHYM-K
BUBR1_Hsap       KIYA-G-VGEFSFEEIRAEVF------------RKKLKEQREA-E-------LLTSAE-K
Bub1_Ddis        LFTKENEKHEISFEEYRASLF------------KKKLIEKQEQ-Q-------N-------
BUB1_Spur        LIYG-G-AREMSFEELRGVKD------------RTKRKERDIQ-A-------KMEEAERL
CC1G_03571_Ccin  ------------------------------------------------------------
CC1G_07078_Ccin  LLWTD-DGVEYSIQEARARSMGL------------LG-----------------------
AqueK151_Aque    --------LQVLPQDKSLTSF--SVYEEASINQP---SFNV------------YEEA---
BUB_a-2_Smoe     ------------------------------------------------------------
BUB_b-2_Smoe     ------------VDEGLARSF------------GSLVLPQ--------------------
BUB_b-1_Smoe     ------------VDEGLARSF------------GSLVVPQ--------------------
BUB_a-1_Smoe     ------------------------------------------------------------


Bub1_Dmel        I---------------------------------------RCYPNFARYSKP---QDLDE
CG14030_Dmel     QTLYDSYETEKSYYMTAVDGALYGQNTSSGQENTGEEDEDND--------AE---EGEEE
BUBR1_Mmus       R---------------------------------------EE--------MQ---KQIEE
BUB1_Mmus        R---------------------------------------KEANAFEEQLLK---QKMDE
R06C7.8_Cele     ----------------------------------------------------RKRKDSGV
BUB1_Scer        R---------------------------------------K----------K---RKLDV
BUB1_Hsap        R---------------------------------------KEANAFEEQLLK---QKMDE
BUBR1_Hsap       R---------------------------------------AE--------MQ---KQIEE
Bub1_Ddis        ----------------------------------------KK--------IE---KEKEE
BUB1_Spur        R---------------------------------------VD--------MVRKHKEHDE
CC1G_03571_Ccin  ------------------------------------------------------------
CC1G_07078_Ccin  ------------------------------------------------------------
AqueK151_Aque    ----------------------------------------------------SINQPSFK
BUB_a-2_Smoe     ------------------------------------------------------------
BUB_b-2_Smoe     ------------------------------------------------------------
BUB_b-1_Smoe     ------------------------------------------------------------
BUB_a-1_Smoe     ------------------------------------------------------------


Bub1_Dmel        LDKFWKPPLVPGLQVVFDKIYNE-------V--EQKEYQPE-----------------EL
CG14030_Dmel     EDG---------------GEENEEDDSDEEEEDDEEEEEHSGPYTNGVQFSAQTTFEQEN
BUBR1_Mmus       MER---------------RLKA--------------------------------------
BUB1_Mmus        LHK---------------KLHQV-------V--ELS---HK-----------------DL
R06C7.8_Cele     VFV---------------K-HQV-------I--DTD---RQ-----------------AR
BUB1_Scer        L-----------------------------V--ER----RQ-----------------DL
BUB1_Hsap        LHK---------------KLHQV-------V--ETS---HE-----------------DL
BUBR1_Hsap       MEK---------------KLKE--------------------------------------
Bub1_Ddis        LDI---------------KLKQE-QKEQKEK--EQKEKEQK-----------------EK
BUB1_Spur        MFA---------------KMQEK-------L--EQQRIQQ-----------------EQY
CC1G_03571_Ccin  ------------------------------------------------------------
CC1G_07078_Ccin  ------------------------------------------------------------
AqueK151_Aque    QSA---------------P-SAR-------P--PLQ---VL-----------------PQ
BUB_a-2_Smoe     ------------------------------------------------------------
BUB_b-2_Smoe     ------------------------------------------------------------
BUB_b-1_Smoe     ------------------------------------------------------------
BUB_a-1_Smoe     ------------------------------------------------------------


Bub1_Dmel        LA--AKWMEK--------RNVTVHGDFD---MEETVCLPGNKMPRRK-SFFPSSFRKSIM
CG14030_Dmel     RSIKIKFRKE--------PSSTYSAYTIENVYQQQ-------------------------
BUBR1_Mmus       -------MQA--------VQQEGAGGQ------------------QE-EKM---------
BUB1_Mmus        PA--------------------------------------------------SENRPDVS
R06C7.8_Cele     EEVENRFNAN--LN----PRRRHLSP-----VSEKTVDDEEEK-RSRI------------
BUB1_Scer        PS--------------------------------------------------SQ------
BUB1_Hsap        PA--------------------------------------------------SQERSEVN
BUBR1_Hsap       -------IQT--------TQQERTGDQ------------------QE-ETM---------
Bub1_Ddis        EELEIKLKQE--------QQEKELQYQQ---HQQK-------------------------
BUB1_Spur        IEL----LVK--------QKVEAMASQQ---IQPPVVQPTPVVPQQP-AQMA--------
CC1G_03571_Ccin  ------------------------------------------------------------
CC1G_07078_Ccin  ------------------------------------------------------KKWGPP
AqueK151_Aque    -DKSLTSFSVYEEASINQPSFKQSAP-----SARPP---LQVLPQD-KSLTS--------
BUB_a-2_Smoe     ------------------------------------------------------------
BUB_b-2_Smoe     ----------------------------------------------------SGQRTGSM
BUB_b-1_Smoe     ----------------------------------------------------SGKRTGSM
BUB_a-1_Smoe     ------------------------------------------------------------


Bub1_Dmel        PRRVSSVQEEDEKKEDE--ATL--I--VK----DI--PSQVAPK--IP-ESP--------
CG14030_Dmel     ------------------------------------------------------------
BUBR1_Mmus       P-----------------------------------------------------------
BUB1_Mmus        LVC-------------------------------------VGQ-----------------
R06C7.8_Cele     ----------------Y--SPL--VATKDAHRPALRSKIENPPA------TVTLSS-DTK
BUB1_Scer        ------------------------------------------------------------
BUB1_Hsap        PAR-------------------------------------MGP-----------------
BUBR1_Hsap       P-----------------------------------------------------------
Bub1_Ddis        ------------------------------------------------------------
BUB1_Spur        PAH-------------P--APV--VP-------QQPA-------QVAPPQAAQGVPFAQY
CC1G_03571_Ccin  ------------------------------------------------------------
CC1G_07078_Ccin  ------------------------------------------------------------
AqueK151_Aque    FSV-------------YEEASINQPSFKQ----SA--PSARPPLQVLP-QDKSLTSFSVY
BUB_a-2_Smoe     ------------------------------------------------------------
BUB_b-2_Smoe     PS----------------------------------------------------------
BUB_b-1_Smoe     PS----------------------------------------------------------
BUB_a-1_Smoe     ------------------------------------------------------------


Bub1_Dmel        ----CDQIDE------------PKIKIFEDSGSPRDNF----------------------
CG14030_Dmel     --------------QQQQ------------------------------------------
BUBR1_Mmus       ------------------------------------------------------------
BUB1_Mmus        ------------------------------NTCSQQEL----------------------
R06C7.8_Cele     SASEKDVSDS------------DDADDDERLKIMTAGRKD--------------------
BUB1_Scer        ------------------------------------------------------------
BUB1_Hsap        ------------------------------SVGSQQEL----------------------
BUBR1_Hsap       ------------------------------------------------------------
Bub1_Ddis        --------------QYQQ--------------------------KQQQQ-----------
BUB1_Spur        A--SAQQGFQTQGSSSQATTRSH--------TSPLDSIADCTDVTKQRHRSNSGGDSTMT
CC1G_03571_Ccin  ------------------------------------------------------------
CC1G_07078_Ccin  ------------------------------------------------------------
AqueK151_Aque    EEASINQPSFKQS-APSARPPLQ--------VLPQDKSLT--------------------
BUB_a-2_Smoe     ------------------------------------------------------------
BUB_b-2_Smoe     ------------------------------------------------------------
BUB_b-1_Smoe     ------------------------------------------------------------
BUB_a-1_Smoe     ------------------------------------------------------------


Bub1_Dmel        --------------------------------AVPAVPVPKIEIY-EDSEEPQPTPKTRP
CG14030_Dmel     ------------------------------------------------------------
BUBR1_Mmus       -----------------------------------TEDPARLQIASGPQEM-----SGVP
BUB1_Mmus        --------------------------------RGPSLSSISHQTSESSGEKPQE-EPSVP
R06C7.8_Cele     -------------------------------GNPPDRST---------------------
BUB1_Scer        -------------------------------------------------------PPVVP
BUB1_Hsap        --------------------------------RAPCLPVTYQQTPVNMEKNPREAPPVVP
BUBR1_Hsap       -----------------------------------TKETTKLQIASESQKI-----PGMT
Bub1_Ddis        ------------------------------------------------------------
BUB1_Spur        CTKQLMFDDLTGAAGNFNIFCDP-------SQGPPAKPAPRYPTVAAAAKP-----PIAP
CC1G_03571_Ccin  ------------------------------------------------------------
CC1G_07078_Ccin  ------------------------------------------------------------
AqueK151_Aque    ---------------SFSVYEETSINQPSFKQSAPARPP---------------------
BUB_a-2_Smoe     ------------------------------------------------------------
BUB_b-2_Smoe     ------------------------------------------------------RPPQKP
BUB_b-1_Smoe     ------------------------------------------------------RPPQKP
BUB_a-1_Smoe     ------------------------------------------------------------


Bub1_Dmel        FYDGD---------------ETCSTQ-MFNM----------FIKSQAVSTPKGTQ-----
CG14030_Dmel     ------------------------------------------------------------
BUBR1_Mmus       L--------------SCSIC----------------------------------------
BUB1_Mmus        LMVNAVNSTLLFPAA-NLPALPVP-V-SGQS----------LTDS----------RCVNQ
R06C7.8_Cele     ------------------------------------------------------------
BUB1_Scer        KS-----------------------T-RIEV----------FKDD----------DNPSQ
BUB1_Hsap        PLANAISAALVSPATSQSIAPPVP-L-KAQT----------VTDSMFAVASK-DAGCVNK
BUBR1_Hsap       L--------------SSSVC----------------------------------------
Bub1_Ddis        ------------------------------------------------------------
BUB1_Spur        L--------------SQSMA----------------------------------------
CC1G_03571_Ccin  ------------------------------------------------------------
CC1G_07078_Ccin  --------------------PP-SELPYYASLAASSSSTTPV------------------
AqueK151_Aque    ------------------------------------------------------------
BUB_a-2_Smoe     ------------------------------------------------------------
BUB_b-2_Smoe     SKGNA---------------PPLSKQ-TFSV----------FVDSELNPASK-VP-----
BUB_b-1_Smoe     SKGNA---------------PPLSNQ-TFSV----------FVDSELNPASK-VP-----
BUB_a-1_Smoe     ------------------------------------------------------------


Bub1_Dmel        ---KQAPSRQFGTVLKELPLPEEAAHSVESPVETRSPTLRKQLSTILETSEHGTQSLATS
CG14030_Dmel     ------------------------------------------------------------
BUBR1_Mmus       ----------------------------PLSSN---------------------------
BUB1_Mmus        SVHEFMPQCGPETK-EVCETNK---------------------------VASIND-----
R06C7.8_Cele     ------------------------------------------------------------
BUB1_Scer        STHHKNTQVQVQTTTSILPLKP---------------------------VVDGNL-----
BUB1_Hsap        STHEFKPQSGAEIK-EGCETHK---------------------------VANTSS-----
BUBR1_Hsap       ----------------------------QVNCC---------------------------
Bub1_Ddis        ------------------------------------------------------------
BUB1_Spur        ---------------------------APTPCNPSSTSAFSVHSVGAPPSKSSQQAEQD-
CC1G_03571_Ccin  ------------------------------------------------------------
CC1G_07078_Ccin  ---------------------------------------------------DFND-----
AqueK151_Aque    ------------------------------------------------------------
BUB_a-2_Smoe     ------------------------------------------------------------
BUB_b-2_Smoe     ------------------GL-----------------------------HENGAQ-----
BUB_b-1_Smoe     ------------------GL-----------------------------HENGAQ-----
BUB_a-1_Smoe     ------------------------------------------------------------


Bub1_Dmel        GTTTKSTITSTSS--PGSNAVSKLGSK-----------IEENTPGQMRLQRVISAGVS--
CG14030_Dmel     ------------------------------------------------------------
BUBR1_Mmus       ------------------------------------------------------------
BUB1_Mmus        ------------------------------------------------------------
R06C7.8_Cele     ------SISSNYS--TASARTSKSGAG---------------------------------
BUB1_Scer        ------------------------------------------------------------
BUB1_Hsap        ------------------------------------------------------------
BUBR1_Hsap       ------------------------------------------------------------
Bub1_Ddis        ------------------------------------------------------------
BUB1_Spur        ------TITPNQSFATNTSSTIPHGAGLNDDKTPQSSMMSEKTPSSA------SFASLSR
CC1G_03571_Ccin  --------------------------------------------RVV------SASAASG
CC1G_07078_Ccin  ------------------------------------------------------------
AqueK151_Aque    ------------------------------------------------------------
BUB_a-2_Smoe     ------------------------------------------------------------
BUB_b-2_Smoe     ------------------------------------------------------------
BUB_b-1_Smoe     ------------------------------------------------------------
BUB_a-1_Smoe     ------------------------------------------------------------


Bub1_Dmel        ---AVLSEPEKPGGDNFLRRELWEPNAPSVPMLKSL-----RFQEDKT-ETIPRPLACFQ
CG14030_Dmel     -----------------------------------------------Q------------
BUBR1_Mmus       ------------------------------------------------------------
BUB1_Mmus        --------------------------FHTTPNT-SLGMVQ-GTPCKVQ------------
R06C7.8_Cele     ------------------------------------------------------------
BUB1_Scer        --------------------------AHETPVKPSL-----TSNASRS------------
BUB1_Hsap        --------------------------FHTTPNT-SLGMVQ-ATPSKVQ------------
BUBR1_Hsap       ------------------------------------------------------------
Bub1_Ddis        -----------------------------------------QSYNPPS------------
BUB1_Spur        SRNGRL------------------------------SNIR-TPKGLTA------------
CC1G_03571_Ccin  SGS---------------------------------------------------------
CC1G_07078_Ccin  --------------------------DNMKST-RTMGMRRRSMLGGAE------------
AqueK151_Aque    ------------------------------------------------------------
BUB_a-2_Smoe     ------------------------------------------------------------
BUB_b-2_Smoe     --------------------------GHALPVWTNL-----GSQAERTKENVQQPTR-WN
BUB_b-1_Smoe     --------------------------GHALPVWTNL-----GSQAERTKENVQQPTR-WN
BUB_a-1_Smoe     ------------------------------------------------------------


Bub1_Dmel        EDKTETLPQ---MPIALPENSMDHGSLG-AENCFSAP-QLPTLEDESDLC----------
CG14030_Dmel     -------E---------------------QHQIIHQPPQ---------------------
BUBR1_Mmus       ------------------------------------------------------------
BUB1_Mmus        -------PSPTVH---------TKEALGFIMDMFQAPT-LPDISDDKDEWPSLDQNEDAF
R06C7.8_Cele     ---------LDLM---------AENKCLE-------------------------------
BUB1_Scer        -------PTVTAF---------SKDAINEVFSMFNQHYSTPGALLDGDD-----------
BUB1_Hsap        -------PSPTVH---------TKEALGFIMNMFQAPT-LPDISDDKDEWQSLDQNEDAF
BUBR1_Hsap       ------------------------------------------------------------
Bub1_Ddis        -------PTMTIH---------TKQAFHDVMAMFSEPLE---------------------
BUB1_Spur        -------PSPTIN---------TKEALGVINAMLNCSLKSNQFDLDGDFQNQVTHQEKDF
CC1G_03571_Ccin  ------------------------------------------------------------
CC1G_07078_Ccin  -------PTVTIN---------TKEALADVFGMYNSPE----------------------
AqueK151_Aque    ---------LQVL---------PQDKSMG-------------------------------
BUB_a-2_Smoe     ------------------------------------------------------------
BUB_b-2_Smoe     EAKIPQRPS---RPVSV-------------------------------------------
BUB_b-1_Smoe     EAKIPQRPS---RPASV-------------------------------------------
BUB_a-1_Smoe     ------------------------------------------------------------


Bub1_Dmel        --GLFGKTPPKT--------------------NIFGSPKRNFDPTSQLFKSTQGDRRSFA
CG14030_Dmel     ------------------------------------------------------------
BUBR1_Mmus       ------------------------------------------------------------
BUB1_Mmus        EAQ-FQKNAVSS--------------------GDWGVKKI--------------------
R06C7.8_Cele     ------------------AHAMFSDTV---------------------------------
BUB1_Scer        ------------------------------------------------------------
BUB1_Hsap        EAQ-FQKNVRSS--------------------GAWGVNKII-------------------
BUBR1_Hsap       ------------------------------------------------------------
Bub1_Ddis        ------------------------------------------------------------
BUB1_Spur        EMD-FA-NAESNDVKPVSKGAVFEDSSAFKRVGGFGSQGI--------------------
CC1G_03571_Ccin  ------------------------------------------------------------
CC1G_07078_Ccin  ------------------------------------------------------------
AqueK151_Aque    ------------------SFSVYEE-----------------------------------
BUB_a-2_Smoe     ------------------------------------------------------------
BUB_b-2_Smoe     ------------------------------------------------------------
BUB_b-1_Smoe     ------------------------------------------------------------
BUB_a-1_Smoe     ------------------------------------------------------------


Bub1_Dmel        VTGNKLEAAPSISNLQDSFMCDLSFVPETQP-------------EA--------------
CG14030_Dmel     ---------------------------------------------AVHHPSP--------
BUBR1_Mmus       ---------------------------------PREISPAENILQE--------------
BUB1_Mmus        ------------------------------------------------------------
R06C7.8_Cele     -------------------------HL-------------ASEKTM-VLGDDSVFVPERS
BUB1_Scer        ------------------------------------------------------------
BUB1_Hsap        ------------------------------------------------------------
BUBR1_Hsap       ---------------------------------ARETSLAENIWQE--------------
Bub1_Ddis        ---------------------------------------------F-EKNNKST-SSSSS
BUB1_Spur        -------------------------IPRRQPLTQRTDQPTEPPRQG--------------
CC1G_03571_Ccin  ------------------------------------------------------------
CC1G_07078_Ccin  ---------------------------KTHKFTPGSKHAPLKKIEPATPMVIPKPTFSNE
AqueK151_Aque    -------------------------ASINQPSFKQSAPPAKPPLQV-L------------
BUB_a-2_Smoe     ------------------------------------------------------------
BUB_b-2_Smoe     ------------------------------------------------------------
BUB_b-1_Smoe     ------------------------------------------------------------
BUB_a-1_Smoe     ------------------------------------------------------------


Bub1_Dmel        VAK------------------------------------S------------------GA
CG14030_Dmel     ---D-----------------------------------P------------------AP
BUBR1_Mmus       QPDS-----------------------------------K------------------GS
BUB1_Mmus        ---------------------------------------M------------------TL
R06C7.8_Cele     LATT-----------------------------------Q-------------------I
BUB1_Scer        ----------------------------------------------------------TT
BUB1_Hsap        ---------------------------------------S------------------SL
BUBR1_Hsap       QPHS-----------------------------------K------------------GP
Bub1_Ddis        LQLN-----------------------------------N------------------VP
BUB1_Spur        VPPS-----------------------------------SAFSSIPIYQDDMKPEIKEAG
CC1G_03571_Ccin  --GS-----------------------------------SG-----------------SS
CC1G_07078_Ccin  NENAKTPSLSFRPFVDENAKTPSLSFRPFVDENAQSKMTT------------------PA
AqueK151_Aque    -PQD-----------------------------------K-------------------S
BUB_a-2_Smoe     ------------------------------------------------------------
BUB_b-2_Smoe     -----------------------------------------------------------S
BUB_b-1_Smoe     -----------------------------------------------------------S
BUB_a-1_Smoe     ------------------------------------------------------------


Bub1_Dmel        IQKFDIFL-------------------------------------DDT------------
CG14030_Dmel     ASPIPIQRQ---------------------------------------------------
BUBR1_Mmus       SMPFSIFD-------------------------------------ESL------------
BUB1_Mmus        SSAFPIFE-------------------------------------DGN------------
R06C7.8_Cele     VTDFSVLC-------------------------------------DPD------------
BUB1_Scer        TSKFNVFE-------------------------------------NFT------------
BUB1_Hsap        SSAFHVFE-------------------------------------DGN------------
BUBR1_Hsap       SVPFSIFD-------------------------------------EFL------------
Bub1_Ddis        SSPNPFTESTLMKSTIDNNKNDNNNNNNNNNNNNNNKNTDVSFDEKSI------------
BUB1_Spur        ATKITIFE-------------------------------------DEP------------
CC1G_03571_Ccin  GSKFAIFR-------------------------------------DPV------------
CC1G_07078_Ccin  PSKLNVFV-------------------------------------DEQNKTPFITPRSAF
AqueK151_Aque    LTSFSVYE-------------------------------------EAS------------
BUB_a-2_Smoe     -MDFNIFV-------------------------------------DDA------------
BUB_b-2_Smoe     TEALDVYV-------------------------------------DE-------------
BUB_b-1_Smoe     TEALDVYV-------------------------------------DE-------------
BUB_a-1_Smoe     -MDFNIFV-------------------------------------DDA------------
                      .

Bub1_Dmel        -----------------------------------------------------------Q
CG14030_Dmel     ------------------------------------------------------------
BUBR1_Mmus       -----------------------------------------------------------S
BUB1_Mmus        -----------------------------------------------------------K
R06C7.8_Cele     -----------------------------------------------------------P
BUB1_Scer        -----------------------------------------------------------Q
BUB1_Hsap        -----------------------------------------------------------K
BUBR1_Hsap       -----------------------------------------------------------L
Bub1_Ddis        ------------------------------------------------------------
BUB1_Spur        -----------------------------------------------------------V
CC1G_03571_Ccin  -----------------------------------------------------------D
CC1G_07078_Ccin  GLKDTTTPSLTQPRNENAPRSAFKPLSTLSEESADKPVFSKVFNPPQTDVPLAPLRDVFT
AqueK151_Aque    -----------------------------------------------------------I
BUB_a-2_Smoe     ----------------------------------------------------------FC
BUB_b-2_Smoe     ------------------------------------------------------------
BUB_b-1_Smoe     ------------------------------------------------------------
BUB_a-1_Smoe     ----------------------------------------------------------FC


Bub1_Dmel        PK--LTK-------------------SK--------------------------------
CG14030_Dmel     -----RNGSHHH------------------------------------------------
BUBR1_Mmus       -DK--KDKSPAT---G----------------------GPQV------------------
BUB1_Mmus        EN--YGL--------------------------------P--------------------
R06C7.8_Cele     ---------TMTITQERPKKVSNGLNVVYDEAAEPEESQ-KV------------------
BUB1_Scer        EF--TAK-------------------NIEDLTEV-----K--------------------
BUB1_Hsap        EN--YGL--------------------------------P--------------------
BUBR1_Hsap       SEK--KNKSPPA---D----------------------PPRV------------------
Bub1_Ddis        EDQ--ENIDPNQ---G----------------------GGGG------------------
BUB1_Spur        DNT--KENSPPS---D----------------------YRQV------------------
CC1G_03571_Ccin  --A--PTPTPPA--------------------------PAAA------------------
CC1G_07078_Ccin  DDH--GKPVPKP---K----------------------AMHTHERAKSHDIGADSKSPAF
AqueK151_Aque    NQPSFKQSAPPA---RPPLQVLPQDKSVYDEASISHPSQPQT------------------
BUB_a-2_Smoe     DDR---------------------------------------------------------
BUB_b-2_Smoe     ------------------------------------------------------------
BUB_b-1_Smoe     ------------------------------------------------------------
BUB_a-1_Smoe     DDR---------------------------------------------------------


Bub1_Dmel        ------PVALMVSSFDLDCTLPETQQVAIKEPGTQQENIGHSHMIASFMKDCTEIGSCPS
CG14030_Dmel     ------------------------------------------------------------
BUBR1_Mmus       ----LNA----------------------------------------------------Q
BUB1_Mmus        -----QP----------------------------------------------------K
R06C7.8_Cele     ----EES----------------------------------------------------E
BUB1_Scer        -----DP----------------------------------------------------K
BUB1_Hsap        -----QP----------------------------------------------------K
BUBR1_Hsap       ----L-A----------------------------------------------------Q
Bub1_Ddis        -----NN----------------------------------------------------D
BUB1_Spur        -----KE----------------------------------------------------K
CC1G_03571_Ccin  -----SS----------------------------------------------------S
CC1G_07078_Ccin  TPFVDEN----------------------------------------------------A
AqueK151_Aque    ----ASS----------------------------------------------------N
BUB_a-2_Smoe     ------------------------------------------------------------
BUB_b-2_Smoe     ------------------------------------------------------------
BUB_b-1_Smoe     ------------------------------------------------------------
BUB_a-1_Smoe     ------------------------------------------------------------


Bub1_Dmel        QMPASVVKT-------------------NIS-------ST--------------------
CG14030_Dmel     FHPYM-----------LGQTSTPKSEANGYRR-AR--TKV--------------------
BUBR1_Mmus       RRPLSVLKT------------------------TE--VGT--------------------
BUB1_Mmus        NKPLGARTF-------------------GERS-------L--------------------
R06C7.8_Cele     VQPEIVLVS------------------------P--------------------------
BUB1_Scer        QETVSQQTT-------------------STNETNDRYERL--------------------
BUB1_Hsap        NKPTGARTF-------------------GERS-------V--------------------
BUBR1_Hsap       RRPLAVLKT------------------------SE--SIT--------------------
Bub1_Ddis        GNPLLSSKITNRDVLMKQLFSKDEDEGNQFDQ----------------------------
BUB1_Spur        REMAGVLQS------------------------SK--SVPF-------------------
CC1G_03571_Ccin  RKPSSSGKA------------------------TK--A----------------------
CC1G_07078_Ccin  KTPFKVFSL------------------------P--------------------------
AqueK151_Aque    TMPMKVLNC------------------------AP--SLSSVPLTTSDASSHCLASIEKL
BUB_a-2_Smoe     ------------------------------------------------------------
BUB_b-2_Smoe     ------------------------------------------------------------
BUB_b-1_Smoe     ------------------------------------------------------------
BUB_a-1_Smoe     ------------------------------------------------------------


Bub1_Dmel        -----SN---------------------KIKFSN--DSMSES------------------
CG14030_Dmel     -----KR---------------------S-KFQP--DLCSNS------------------
BUBR1_Mmus       -----TN---------------------E-DVSP--DICDEL------------------
BUB1_Mmus        -----SK---------------------Y-SSR-----SNEM------------------
R06C7.8_Cele     -VTQTSP---------------------A-TMFN--DIY---------------------
BUB1_Scer        -----SN---------------------S-STRP--EKADYM------------------
BUB1_Hsap        -----SR---------------------L-PSKP----KEEV------------------
BUBR1_Hsap       -----SN---------------------E-DVSP--DVCDEF------------------
Bub1_Ddis        ------------------------------------------------------------
BUB1_Spur        ----MSL---------------------E-DQEQEDAIGMDA------------------
CC1G_03571_Ccin  ------------------------------------------------------------
CC1G_07078_Ccin  -------GTNDENALGRAN-----------------------------------------
AqueK151_Aque    SLSQKAPVTISTSLHSHNFPVPSSITNQE-QPLP--NITNPVSSTHSLPVPFSINNPLPP
BUB_a-2_Smoe     ------------------------------------------------------------
BUB_b-2_Smoe     ------------------------------------------------------------
BUB_b-1_Smoe     ------------------------------------------------------------
BUB_a-1_Smoe     ------------------------------------------------------------


Bub1_Dmel        -----------------------------SRKAPVNE-----------N--VGISKQPD-
CG14030_Dmel     -----------------------------N------SA---SSVADVASS-SVLAGAPG-
BUBR1_Mmus       -----------------------------TELEPLSED---AIITGFR-N-VTLCPNPE-
BUB1_Mmus        -----------------------------PHTDEFMDD---STVCGIRCN-KTLAPSPK-
R06C7.8_Cele     ------------------------------------DD---EIEFGFFK--------P--
BUB1_Scer        -----------------------------TPIKETTET---DVVPIIQTPKEQIRTEDK-
BUB1_Hsap        -----------------------------PHAEEFLDD---STVWGIRCN-KTLAPSPK-
BUBR1_Hsap       -----------------------------TGIEPLSED---AIITGFR-N-VTICPNPE-
Bub1_Ddis        ------------------------------------ER---DMVKTIE-R-IDLLVKGK-
BUB1_Spur        -----------------------------MEVQPSTDPSQHRDLSHTM-N-VTLPRTGAS
CC1G_03571_Ccin  -------------------------------FVPFVDE---ADVK---------KPSPIP
CC1G_07078_Ccin  ---------------------------------PFTPK---TPTPAVFT--PFVDPKPEP
AqueK151_Aque    PLDALPVPQSVTTPPTNEQEAESISPESGTHSHPLVNE---TIDPSFFIP-GYLSDDPT-
BUB_a-2_Smoe     ------------------------------------------------------------
BUB_b-2_Smoe     ------------------------------------------------------------
BUB_b-1_Smoe     ------------------------------------------------------------
BUB_a-1_Smoe     ------------------------------------------------------------


Bub1_Dmel        EFFELN--AATEMFATNISMIK--N-----------------------------------
CG14030_Dmel     TFNDNA--NFSFSSATALDNSN--S-----------------------------------
BUBR1_Mmus       DTCDFA--RAARLASTPFHEIL--S-----------------------------------
BUB1_Mmus        SIGDFT--SAAQLSSTPFHKFP--A-----------------------------------
R06C7.8_Cele     -------SRGNFVTSTPAQ--GVH---------------LVN------------------
BUB1_Scer        KSGDNT-ETQTQLTSTTIQSSP--F-----------------------------------
BUB1_Hsap        SPGDFT--SAAQLASTPFHKLP--V-----------------------------------
BUBR1_Hsap       DTCDFA--RAARFVSTPFHEIM--S-----------------------------------
Bub1_Ddis        DTPKFEIFEDSTLASSQLHSKS-VSLADKVASK------NKQLNPLEQSQNPLKKSILGS
BUB1_Spur        SNYSFE--VAARMASTPFNDAS--S-----------------------------------
CC1G_03571_Ccin  -P-ETP--RAATPKFTPFRDEG--D-----------------------------------
CC1G_07078_Ccin  AFTPFG--SSTNRAFTPFADKT--P-----------------------------------
AqueK151_Aque    STPCG--GRR--VGLAPFDVTAIQS-------YSPQSSNTKPLPPPPP------------
BUB_a-2_Smoe     ------------------------------------------------------------
BUB_b-2_Smoe     ------------------------------------------------------------
BUB_b-1_Smoe     ------------------------------------------------------------
BUB_a-1_Smoe     ------------------------------------------------------------


Bub1_Dmel        -----------STLLIPNAK-----------VAEASEL----------------------
CG14030_Dmel     -----------S-LALAVD--------------RL-------NFRD--T-----------
BUBR1_Mmus       -----------S-KGIAADPEGL------LQEEDLDGKAAEA--------H---------
BUB1_Mmus        -----------DLVQIPEDKENV------VATQYTHMA-------------L---D----
R06C7.8_Cele     ------------------------------IDEYFGNKEEES--------T---HE----
BUB1_Scer        -----------LT-QPEPQAEKL------LQTAEHSEK----------------------
BUB1_Hsap        -----------ESVHILEDKENV------VAKQCTQAT-------------L---D----
BUBR1_Hsap       -----------L-KDLPSDPERL------LPEEDLDVKTSED--------QQ---T----
Bub1_Ddis        SGINGINGNNGG-FTIFQD--------------QP-------NQEKKQP-----------
BUB1_Spur        -----------L-KLSFIPPMST------IKPREVEQDKEEEMVMPMQQGTVAADV----
CC1G_03571_Ccin  ------------------------------------------------------------
CC1G_07078_Ccin  -----------A-QSTAFKPEPEPEPEHEAYEEEHQQAYEEEEVYA-QEEEYSYDEEHIE
AqueK151_Aque    -----------L-PVPSLPPPPP-----PPPPSQPLP-QTDP--------A---------
BUB_a-2_Smoe     ------------------------------------------------------------
BUB_b-2_Smoe     ------------------------------------------------------------
BUB_b-1_Smoe     ------------------------------------------------------------
BUB_a-1_Smoe     ------------------------------------------------------------


Bub1_Dmel        -----------------------S------------------------------------
CG14030_Dmel     ------------------------------------------------------------
BUBR1_Mmus       -----------------------------------------------HTVHH--------
BUB1_Mmus        ----------------------SC-----------------------KENIV--------
R06C7.8_Cele     ----------------------QEAP---------------------VFVAPTSSTFSKL
BUB1_Scer        -----------------------S-----------------------KE-----------
BUB1_Hsap        ----------------------SC-----------------------EENMV--------
BUBR1_Hsap       ----------------------AC-----------------------GTIYS--------
Bub1_Ddis        ------------------------------------------------------------
BUB1_Spur        ----------------------ACSKSEVVGASASRVIQASVNESFEKTEFA--------
CC1G_03571_Ccin  ------------------------------------------------------------
CC1G_07078_Ccin  QYQAPLAPEHIQEGYDEGSSYHHEAP----------------------------------
AqueK151_Aque    -------------------------P---------------------PIMQP--------
BUB_a-2_Smoe     ------------------------------------------------------------
BUB_b-2_Smoe     ------------------------------------------------------------
BUB_b-1_Smoe     ------------------------------------------------------------
BUB_a-1_Smoe     ------------------------------------------------------------


Bub1_Dmel        ------I-YY---K-TTPL-TPKQ---------S-H-RSWS-------------QSDLET
CG14030_Dmel     -----SQ-QQ---I-LHPV-NKTLQIHNNNNNTS-NNNN----------------GTSTM
BUBR1_Mmus       ---QALI-IK---K-LSPI-IEESREA---THSS-GFSRSS----------------SSA
BUB1_Mmus        ---DLSK-GR---K-LGPI-QEKISA--------------S-------------LPCPSQ
R06C7.8_Cele     TRRKSLAANQ---A-VQPS-VTESSKP---ERSDPKDSSID----------------CLT
BUB1_Scer        ------------------------------------------------------------
BUB1_Hsap        ---VPSR-DG---K-FSPI-QEKSPKQ---ALSS-HMYSAS-------------LLRLSQ
BUBR1_Hsap       ---QTLS-IK---K-LSPI-IEDSREA---THSS-GFSGSS----------------ASV
Bub1_Ddis        -----LQ-QS---QLQNPLKNSILGISDANGNGG-GGGS----------------G-SGS
BUB1_Spur        ---VDHS-AG---H-LSPI-METSAEN---ARSS-ASSSAS--------------TTNSH
CC1G_03571_Ccin  ------------------------------------------------------------
CC1G_07078_Ccin  ---LGGR-FGQFSV-MTPI-AERTCEF---TTST-RGGTTPSDRYGRPQDGEGSPKSKHA
AqueK151_Aque    ---YSFR-GQ---H-LDPI-QEESRSY---CSSS-SGSTTT----------------CSS
BUB_a-2_Smoe     ------------------------------------------------------------
BUB_b-2_Smoe     ------------------------------------------------------------
BUB_b-1_Smoe     ------------------------------------------------------------
BUB_a-1_Smoe     ------------------------------------------------------------


Bub1_Dmel        P-------PR------E-----NFVH--------------------------PTSN----
CG14030_Dmel     A-------DFSTF-----------Q-ENS-----YFAT-----QH-DT----EAQERRLS
BUBR1_Mmus       P-------STSSI-----------K-GFQ-------------------------------
BUB1_Mmus        P-------ATGGLFTQEAVFGLEAFKCTG----IDHAT----VED-LS----DANA----
R06C7.8_Cele     A-------NLGRR--------LSI-GADE----IPNLT-----EN-NE----SEIT----
BUB1_Scer        --------------------------------------------H-YP----TIIP----
BUB1_Hsap        P-------AAGGVLTCEAELGVEACRLTD----TDAAI----AED-PP----DAIA----
BUBR1_Hsap       A-------STSSI-----------K-CLQ-------------------------------
Bub1_Ddis        G-------GFTIF-----------Q-DQAAEEKKPFNE-----KE-QQQQEEKEKENKIE
BUB1_Spur        A-------SASSL-----------E-CHQ-------PS-----YH-NQ----EDREKDIA
CC1G_03571_Ccin  ------------------------------------------------------------
CC1G_07078_Ccin  PFLRDELVAARDARRLEAELQ--DDTSEE----LMQGRDEGEDEEAYG----EDQG----
AqueK151_Aque    K-------NLSTH--------SNASRSAN----ISQQS-----QH-NE----DEEP----
BUB_a-2_Smoe     ------------------------------------------------------------
BUB_b-2_Smoe     ------------------------------------------------------------
BUB_b-1_Smoe     ------------------------------------------------------------
BUB_a-1_Smoe     ------------------------------------------------------------


Bub1_Dmel        ----G-------------------------------------------------------
CG14030_Dmel     KAVET-------------------------------------------------------
BUBR1_Mmus       ------------------------------------------------------------
BUB1_Mmus        ----G-------------------------------------------------------
R06C7.8_Cele     ------------------------------------------------------------
BUB1_Scer        ----P-------------------------------------------------------
BUB1_Hsap        ----G-------------------------------------------------------
BUBR1_Hsap       ------------------------------------------------------------
Bub1_Ddis        EEEEEE--EKDKEKEINYQNITGN-----------ITS----------------------
BUB1_Spur        PSSQGFTIHMDEEPHAQYQPKTGSAASGFHIHVDNNESSAAAPEVPTSFRAKDNSCLHKD
CC1G_03571_Ccin  ------------------------------------------------------------
CC1G_07078_Ccin  ----G-------------------------------------------------------
AqueK151_Aque    ------------------------------------------P-----------------
BUB_a-2_Smoe     ------------------------------------------------------------
BUB_b-2_Smoe     ------------------------------------------------------------
BUB_b-1_Smoe     ------------------------------------------------------------
BUB_a-1_Smoe     ------------------------------------------------------------


Bub1_Dmel        ------------------D-------------QT---VLNETL-ADANKNPFNVELISSL
CG14030_Dmel     --------------------------------------IARHM-DKEAIDPFNSELCRAF
BUBR1_Mmus       --------------------LLE--------KLE---LTNDGA-EDAIQSPWCSQYRLQL
BUB1_Mmus        ------------------LQVEC---------VQT--LGNVNAPSFTVENPWDDELILKL
R06C7.8_Cele     -------------------GC-K---------IRR---RSEII-KQGDINPWDETLRKKL
BUB1_Scer        ----------------------------------F--TKIKNQPPVIIENPLSNNLRAKF
BUB1_Hsap        ------------------LQAEW-------MQMSS--LGTVDAPNFIVGNPWDDKLIFKL
BUBR1_Hsap       --------------------IPE--------KLE---LTNETS-ENPTQSPWCSQYRRQL
Bub1_Ddis        --------------------TI---------DPTTVIICSLTP-DDGIVNPYLIDHQYLL
BUB1_Spur        DLPDLEMSFIPDRTIQDAEQVEQ--------DITT--FGMGEE-PLDYSDPFNAGLQNLL
CC1G_03571_Ccin  ------------------------------------------------------------
CC1G_07078_Ccin  ------------------LQLEERTGALSLVDTLT--LNSKF-RPPNPCNPFDPPIMSTL
AqueK151_Aque    -------------------EV-Q--------DLRS---LGVMN-LKRQVNPFTPETIQFM
BUB_a-2_Smoe     ----------------------------------------RD-RKIEFVDPWDETLVADL
BUB_b-2_Smoe     ------------------------------------------------------------
BUB_b-1_Smoe     ------------------------------------------------------------
BUB_a-1_Smoe     ----------------------------------------RD-RKSEFVDPWDETLVADL


Bub1_Dmel        LESIDFS----MYIE-------KLPHCQLVGHV--------KRLHPNTHLEV-H--NEKF
CG14030_Dmel     LAKLDFPGNHDAHASYKIVQ-TPLPK-----------------ISNTRTLNVLEGV--TF
BUBR1_Mmus       LKSLLE-LS--AFAEFSVED-RPMPV-----------------LEIGKEIEL-GPE--DY
BUB1_Mmus        LSGLSKPVT--SYSNTFEWQ-SKLPA-----------------IKTKTEYQL-G--SLLV
R06C7.8_Cele     MCLVRPP-Q--NM---HEFQ-ERAPK-----------------IQALRDCEV-S--GEKL
BUB1_Scer        LSEISPPLF--QYNTFYNYN-QELKMSSLLKKIHRVSR--NENKNPIVDFKK-T--GDLY
BUB1_Hsap        LSGLSKPVS--SYPNTFEWQ-CKLPA-----------------IKPKTEFQL-G--SKLV
BUBR1_Hsap       LKSLPE-LS--ASAELCIED-RPMPK-----------------LEIEKEIEL-GNE--DY
Bub1_Ddis        EQHVSATVQSI-QSFFNVGD-DLAPL-----------------PEQLD-QCEP-NQ--LF
BUB1_Spur        LAGLSKPLS--MYKGIYQHD-HMMPA-----------------IKTDLAVSF-GDEIHVY
CC1G_03571_Ccin  ------------------------------------------------------------
CC1G_07078_Ccin  LSRVQTDSH--FYD-LREYSSQKLDQ--LQKFFKKGGRKNSTTVTDLFPLTL-E--NNRF
AqueK151_Aque    LQSLPITVT--PV---HRLP-KSSPS-----------------MTTGHTVTL-AD-GSSC
BUB_a-2_Smoe     LKKLAPP-----------------------------------------------------
BUB_b-2_Smoe     ------------------------------------------------------------
BUB_b-1_Smoe     ------------------------------------------------------------
BUB_a-1_Smoe     LKKLAPP-----------------------------------------------------


Bub1_Dmel        EVSKM--------------------IGKGAYG-SVY----VGKH----------------
CG14030_Dmel     SIDKE--------------------VGRGSYG-SVY----KATD----------------
BUBR1_Mmus       VIKQE-------------------HLTCDDYR-LFW----VAPR----------------
BUB1_Mmus        YVNHL--------------------LGEGAFA-QVF----EAIHGDV-------------
R06C7.8_Cele     HIQTL--------------------IGQGGYA-KVY----RAVT----------------
BUB1_Scer        CIRGE--------------------LGEGGYA-TVY----LAES----------------
BUB1_Hsap        YVHHL--------------------LGEGAFA-QVY----EATQGDL-------------
BUBR1_Hsap       CIKRE-------------------YLICEDYK-LFW----VAPR----------------
Bub1_Ddis        EDNSIIVQWPFSDITVNFTKCVCKSTMDGSMTFKVERIDDLAMT----------------
BUB1_Spur        SVMEK--------------------VGEGAFA-TIY----LAACLDAL------------
CC1G_03571_Ccin  ------------------------------------------------------------
CC1G_07078_Ccin  MLSEK--------------------LGEGGFG-SVY----KARDLGMRTGDDDDDDDDDD
AqueK151_Aque    SVIGK--------------------LAKGGFA-SVY----NVKM----------------
BUB_a-2_Smoe     ------------------------------------------------------------
BUB_b-2_Smoe     ------------------------------------------------------------
BUB_b-1_Smoe     ------------------------------------------------------------
BUB_a-1_Smoe     ------------------------------------------------------------


Bub1_Dmel        -------LKSGKKVALKQERPTNYWEFYICLEIHSRLTSEQM----IPSYAHIDYALVGN
CG14030_Dmel     -------SRTGNVVALKYQKPPNTWEIYICDQVLKRIKEPEV----LPGVMDISTAIIAP
BUBR1_Mmus       --------SSAELTMIKASSQPIPWDFYINLKLKERLNEDY---------DQLCSCCQYQ
BUB1_Mmus        ----R-NAKSEQKCILKVQRPANSWEFYIGMQLMERLKPE-V----HHMFIKFYSAHLFK
R06C7.8_Cele     --------DDQRTVAVKYEVPSCSWEVYICDQMRNRLKDRGLELMAKCCIMEVMDAYVYS
BUB1_Scer        --------SQGHLRALKVEKPASVWEYYIMSQVEFRLRKSTI----LKSIINASALHLFL
BUB1_Hsap        ----N-DAKNKQKFVLKVQKPANPWEFYIGTQLMERLKPS-M----QHMFMKFYSAHLFQ
BUBR1_Hsap       --------NSAELTVIKVSSQPVPWDFYINLKLKERLNEDF---------DHFCSCYQYQ
Bub1_Ddis        -------TSEDSWLSCKVQDPPSIWEFYIGNQIHQRLQERSLTI-SNSKFPTIHSLYYYT
BUB1_Spur        --DMTDLDRDFRRVALKVQHPPCPWEMYVIKELHARLSRLPSQIDVRPSIMTAECAHIYQ
CC1G_03571_Ccin  ------------------------------------------------------------
CC1G_07078_Ccin  FDDFDDDEENASMVAIKVVKPRNLWEYHALRRLHSALPANL-----RRSLVLPHGLYAYG
AqueK151_Aque    --------MNGSTKALKIQNPPCLWEVAIIEELHKRLKANDLLK-FSQCFMSVDAVHLYT
BUB_a-2_Smoe     ------------LQTCKIQKPPCPWEFYIYYQLDKRIPVEE-----RDSFGSARKMYVFS
BUB_b-2_Smoe     ------------------------------------------------------------
BUB_b-1_Smoe     ------------------------------------------------------------
BUB_a-1_Smoe     ------------LQTYKIQKPPCPWEFYIYYQLDKRIPVEE-----RDSFGSARKMYVFS


Bub1_Dmel        NSSVYISEF-SDYGSLIGVCNKVKSVT----NRNMDEYVVMHLSCQMLDIVDHLHAMGII
CG14030_Dmel     NASLIATEF-SPFGSLLDINNKIRQAT----TKVMHESLVMHFSAQICNIVDHLHRQHII
BUBR1_Mmus       DGHVVWYQY-INCSTLQNLLQHSE---------FVTHEIIVLIIYNLLTIVEKLHRAEIV
BUB1_Mmus        NGSILVGEL-YSYGTLLNVINLYKNTS----EKVMPQALVLTFAIRMLYMVEQVHSCEII
R06C7.8_Cele     TASLLVNQY-HEYGTLLEYANNMKDPN---------WHITCFLITQMARVVKEVHASKII
BUB1_Scer        DESYLVLNY-ASQGTVLDLINLQREKAID-GNGIMDEYLCMFITVELMKVLEKIHEVGII
BUB1_Hsap        NGSVLVGEL-YSYGTLLNAINLYKNTP----EKVMPQGLVISFAMRMLYMIEQVHDCEII
BUBR1_Hsap       DGCIVWHQY-INCFTLQDLLQHSE---------YITHEITVLIIYNLLTIVEMLHKAEIV
Bub1_Ddis        DKSIMLMDHTIDQGTLDDVVSST---N----GVPMEEPLAMFHCIELLKMIEDLHLVGII
BUB1_Spur        DKSCMVTEY-KSKGTLLDLINKVKAVN----KKDLSEDWVLFFAIEILQTVEYMHRCKII
CC1G_03571_Ccin  ------------------------------------------------------------
CC1G_07078_Ccin  DESFLILDL-CTQGMLLDIVNNAASAGISQAGACLDELLVIFFTIELLRLVEGMHSAGFI
AqueK151_Aque    NSSIIAYNY-YPHGTLLDLVNTCRTTS-----KKLTEAVLLYYTTEICQLVEALHCCGII
BUB_a-2_Smoe     DCSILVAGY-GQHGTLQDVVNAYLAH-----SLKMDELLCMYYTIEMLRMLEVLHGVGII
BUB_b-2_Smoe     --EFT-------------------------------------------------------
BUB_b-1_Smoe     --EFS-------------------------------------------------------
BUB_a-1_Smoe     DCSILVAGY-GQHGTLQDVVNAYLAH-----SLKMDELLCMYYTIEMLRMLEVLHGVGII


Bub1_Dmel        HADIKPDNFLLMKPIC-----------------ADPNEVSLQLIDFGVSIDMKLFPDN--
CG14030_Dmel     HADIKPDNFLLMRVPNVD-----------------SPLPSLRLIDFGCAIDMTLFPDGEK
BUBR1_Mmus       HGDLSPRSLILRNRIH-DPYDY-----------VNKDDHAVRIMDFSYSVDLRVQLDA--
BUB1_Mmus        HGDIKPDNFILGHRFLE-------------QADE-DLATGLALIDLGQSIDMKLFPKG--
R06C7.8_Cele     HGDIKPDNFMITRKID-DKWGKD----A---L-MSNDSFVIKIIDWGRAIDMMPL-KN--
BUB1_Scer        HGDLKPDNCMIRLEKPGEPLGAH----YMRNGEDGWENKGIYLIDFGRSFDMTLLPPG--
BUB1_Hsap        HGDIKPDNFILGNGFLE-------------QDDEDDLSAGLALIDLGQSIDMKLFPKG--
BUBR1_Hsap       HGDLSPRCLILRNRIH-DPYD------------CNKNNQALKIVDFSYSVDLRVQLDV--
Bub1_Ddis        HGNICANNLHFLFGQTSDWPDWT----AGE-CKGAWKSKGFTLTDFSRSIDTTIYSQD--
BUB1_Spur        HGDIKPDNFLINTDND-ENFTC-----------SQEPSSLVKLIDFGRSIDMTLFPEG--
CC1G_03571_Ccin  ------------------------------------------------------------
CC1G_07078_Ccin  HGDLKIDNCLLRLEDVP-GGAAAWSSLYQPSGEGGWQYKGLKVIDFGRTIDTRLFPAD--
AqueK151_Aque    HADIKPDNIMLRDIR--PITDY-----------TSIRGRGVCLLDFGRAIDAQSFPRG--
BUB_a-2_Smoe     HADFKPDNLLIRNES---------------R-GLCLALQGLCLIDWGRSIDMRLFPEG--
BUB_b-2_Smoe     ------------------------------------------------------------
BUB_b-1_Smoe     ------------------------------------------------------------
BUB_a-1_Smoe     HADFKPDNLLIRNDRYL-LVS-------VPR-GLCLALQGLCLIDWGRSIDMRLFPEG--


Bub1_Dmel        QTFNYVHHDDL-------FK-CIEMRTGRPWTYQLDLYGLVSVMHVLL-FGRY-MEVVQR
CG14030_Dmel     TKFRKVVQTDG-------FT-CIEMQEGRSWSYETDLFCIAATVHVML-FGDY-MQPQKK
BUBR1_Mmus       FAYSGFRTAQI-------LE-GQKILANCSSPYHVDLLGIADLAHLLL-FKEH-LHVFWD
BUB1_Mmus        TVFTGKCETSG-------FQ-CPEMLSNKPWNYQIDYFGVAATIYCML-FGSY-MKVK-N
R06C7.8_Cele     QRFKGRAGTEA-------FD-CPEMVDGRSWTYQADYFGFAATMAVVV-AGKY-AQLTGA
BUB1_Scer        TKFKSNWKADQ-------QD-CWEMRAGKPWSYEADYYGLAGVIHSML-FGKF-IETIQL
BUB1_Hsap        TIFTAKCETSG-------FQ-CVEMLSNKPWNYQIDYFGVAATVYCML-FGTY-MKVK-N
BUBR1_Hsap       FTLSGFRTVQI-------LE-GQKILANCSSPYQVDLFGIADLAHLLL-FKEH-LQVFWD
Bub1_Ddis        ARYQSPIELLPIGTPLEWLKINQSSTTNVGWSYNLDYLGICKVMFHILTCGKEELKLSLS
BUB1_Spur        TVFTAKCKTSG-------FN-CTEMQSDQPWTYQVDYYGIAGTVHCLM-FGKY-MKVFRE
CC1G_03571_Ccin  ------------------------------------------------------------
CC1G_07078_Ccin  QQFIAEWPTDE-------RD-CFEIREGRPWTYQTDYFGLAGIIYCML-FGKY-ITSSAV
AqueK151_Aque    TQFVGSCGTDS-------FQ-CIQMLNNEPWSWHTDLHCIAGTVHVLL-HLDY-MEVIKN
BUB_a-2_Smoe     TEFLADSKTSA-------FR-CIEMMEERPWTYQVDGYGLCCIVHCML-HGSY-MELEEE
BUB_b-2_Smoe     ------------------------SVASRSWNR---------------------------
BUB_b-1_Smoe     ------------------------SVASRSWNR---------------------------
BUB_a-1_Smoe     TEFFADSKTSA-------FR-CIEMVEERPWTYQVDGYGLCCIVHCML-HGSY-MELEEE


Bub1_Dmel        ------SPSTIWM---PKTNVPR-Y----FQRTMWENIFRTLLNIRDCRT---MP----N
CG14030_Dmel     --------GSSWE---IRQKLPR-Y----LKKHVWTKFFGDLLNMQADKL----P----A
BUBR1_Mmus       --------GLLWK---LSQSTSE-L----KDSELWNKFFVRILNASDKS---TVS----V
BUB1_Mmus        ------E-GGVWK---PEGLFRR-L----PHLDMWEEFFHIMLNIPDCHN---LP----S
R06C7.8_Cele     ------S-VGDYS---LNVDIKRRN----ILRDACYDVINRFLNIPSCD---SLP----D
BUB1_Scer        ------Q-NGRCK---LKNPFKR-Y----WKKEIWGVIFDLLLNSGQASN-QALP----M
BUB1_Hsap        ------E-GGECK---PEGLFRR-L----PHLDMWNEFFHVMLNIPDCHH---LP----S
BUBR1_Hsap       --------GSFWK---LSQNISE-L----KDGELWNKFFVRILNANDEA---TVS----V
Bub1_Ddis        --------QQTGKLEIINQSIIQ-KDSFSELDTLWLPFLTTLLNHNGENGNQQTTTTTYI
BUB1_Spur        --------GGIWK---MTSKVPR-C----AKV-DWKGFFHTLLNVPSCDP-SDLP----H
CC1G_03571_Ccin  ------------------AESSR-AT---AVP-VGDAVIKVKKT--G-PK-APVP----T
CC1G_07078_Ccin  VQVQGQHGETRYK---IGTPLKR-Y----WQADLWNRLFDILLNPTLIRPGGELP----L
AqueK151_Aque    ------AMTGEYV---PSKSLPR-N----YDRVLWMKFFTDLLNWSGE----GQP----D
BUB_a-2_Smoe     ---RSPDGGRVHK---PKASLKR-Y----WNTNVWDKFFKTLLNASPPL-----P-----
BUB_b-2_Smoe     --------------------------------RISTAALKVRLSRGQDIK---ID-----
BUB_b-1_Smoe     --------------------------------RISTAALKVRLSRGQDIK---ID-----
BUB_a-1_Smoe     ---RSPDGGRVHK---PKASLKR-Y----WNTNVWDKFFKTLLNASPPL-----P-----
                                                       :    .

Bub1_Dmel        --L---QQLRTQLKCALAEK---E-K-YVAE-------AI-----------SKFNTILQK
CG14030_Dmel     --L---HEMRLIFEEEAYRM--D--S-EL----QKQ-------------IRTLSNILHRR
BUBR1_Mmus       --L---GELAAEMGGAFDAT--FH-S-HLNRALWKLGKTISPEALLTQQDKQPGGSQSPA
BUB1_Mmus        --L---DFLRQNMKKLLEQQ--YS-N-KIKTLRNRLIVML-----------S-EYKRSRK
R06C7.8_Cele     --W---NILIKSFSEIWNEK--FE-ASGWRQAVSKFN-------------EACDLAANQK
BUB1_Scer        --TEKIVEIRNLIESHLEQH--AE-N-HLRNVILSIEEEL----SHFQ---YKGKPSRRF
BUB1_Hsap        --L---DLLRQKLKKVFQQH--YT-N-KIRALRNRLIVLL-----------L-ECKRSRK
BUBR1_Hsap       --L---GELAAEMNGVFDTT--FQ-S-HLNKALWKVGKLTS------------PGALLFQ
Bub1_Ddis        --L---KQQRNLFENYLQSNP-VK-S-KIKSLLRIQN------------IKLFESMKSKQ
BUB1_Spur        --L---GDLRRQLEKHVNPS--KK-A-DIH---------FH------------MDVLLSD
CC1G_03571_Ccin  SEA---EALRKDP--------------------------LK------------NYSTNDT
CC1G_07078_Ccin  --PKELAGVRVDMEAWLQANCNRTSN-TLKGLLKK------------------VEMSCYR
AqueK151_Aque    --M---KALTQPLSRKLSLN---V-S-HLKLNLNYMWT------------QMERQRGFPK
BUB_a-2_Smoe     -----LSSLREMLEQTIVSNAAHP-R-RLKELLIKQT----------------VMMYPRR
BUB_b-2_Smoe     ---------TEMLK---------------QA-------PL-----------RN-FSRELR
BUB_b-1_Smoe     ---------TEMLK---------------QA-------PL-----------RN-FSRELR
BUB_a-1_Smoe     -----LSSLREMLEQTIVSNAAHP-R-RLKELLIKQT----------------VMMYPRR