PRP4_Hsap_PRP4 ------------------------------------------------------------
HIPK4_Hsap_HIPK ------------------------------------------------------------
HIPK3_Hsap_HIPK ------------------------------------------------------------
HIPK2_Hsap_HIPK ------------------------------------------------------------
HIPK1_Hsap_HIPK ------------------------------------------------------------
smi35A_Dmel_DYRK2 ------------------------------------------------------------
mnb_Dmel_DYRK1 ------------------------------------------------------------
Dyrk3_Dmel_DYRK2 ------------------------------------------------------------
CG17090_Dmel_HIPK ------------------------------------------------------------
PRP4_Mmus_PRP4 ------------------------------------------------------------
HIPK4_Mmus_HIPK ------------------------------------------------------------
HIPK3_Mmus_HIPK ------------------------------------------------------------
HIPK2_Mmus_HIPK ------------------------------------------------------------
HIPK1_Mmus_HIPK ------------------------------------------------------------
DYRK4_Mmus_DYRK2 ------------------------------------------------------------
DYRK3_Mmus_DYRK2 ------------------------------------------------------------
DYRK2_Mmus_DYRK2 ------------------------------------------------------------
DYRK1B_Mmus_DYRK1 ------------------------------------------------------------
DYRK1A_Mmus_DYRK1 ------------------------------------------------------------
mbk-2_Cele_DYRK2 ------------------------------------------------------------
mbk-1_Cele_DYRK1 ------------------------------------------------------------
hpk-1_Cele_HIPK ------------------------------------------------------------
F22D6.5_Cele_PRP4 ------------------------------------------------------------
C36B7.2_Cele_DYRK2 ------------------------------------------------------------
C36B7.1_Cele_DYRK2 ------------------------------------------------------------
DYRK4_Hsap_DYRK2 ------------------------------------------------------------
DYRK3_Hsap_DYRK2 ------------------------------------------------------------
DYRK2_Hsap_DYRK2 ------------------------------------------------------------
DYRK1B_Hsap_DYRK1 ------------------------------------------------------------
DYRK1A_Hsap_DYRK1 ------------------------------------------------------------
YAK1_Scer_YAK ------------------------------------------------------------
Dyrk1_Ddis_DYRK1 ------------------------------------------------------------
Dyrk2_Ddis_DYRK2 ------------------------------------------------------------
Prp4_Ddis_PRP4 ------------------------------------------------------------
YakA_Ddis_YAK ------------------------------------------------------------
22349_Tthe_YAK ------------------------------------------------------------
10580_Tthe_DyrkP ------------------------------------------------------------
22423_Tthe_DyrkP ------------------------------------------------------------
5306_Tthe_DYRK2 ------------------------------------------------------------
5356_Tthe_DYRK2 ------------------------------------------------------------
5655_Tthe_DYRK2 ------------------------------------------------------------
15575_Tthe_PRP4 KQ----------------------------------------------------------
DYRK1_Spur_DYRK1 ------------------------------------------------------------
DYRK2_Spur_DYRK2 ------------------------------------------------------------
DYRK4_Spur_DYRK2 ------------------------------------------------------------
HIPKa_Spur_HIPK ------------------------------------------------------------
HIPKb_Spur_HIPK ------------------------------------------------------------
PRP4_Spur_PRP4 KHKHKSKKSHHKHKHHKENKDGHRRHKHKHKKHKSKKDEEPPVATPAADESESDIELEDT
CG7028_Dmel_PRP4 ------------------------------------------------------------
CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------
CC1G_04865_Ccin_PRP4 ------------------------------------------------------------
CC1G_14245_Ccin_YAK ------------------------------------------------------------
AqueK110_Aque_DYRK1 ------------------------------------------------------------
AqueK111_Aque_DYRK1 ------------------------------------------------------------
AqueK112_Aque_DYRK2 ------------------------------------------------------------
AqueK113_Aque_DYRK2 ------------------------------------------------------------
AqueK114_Aque_HIPK ------------------------------------------------------------
AqueK115_Aque_PRP4 ------------------------------------------------------------
AqueK116_Aque_PRP4 ------------------------------------------------------------
DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------
DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------
DYRKP-2_Smoe_DYRKP ------------------------------------------------------------
DYRKP-1_Smoe_DYRKP ------------------------------------------------------------
PRP4_e_Smoe_PRP4 ------------------------------------------------------------
PRP4_d_Smoe_PRP4 ------------------------------------------------------------
PRP4_b_Smoe_PRP4 ------------------------------------------------------------
PRP4_a_Smoe_PRP4 ------------------------------------------------------------
PRP4_c_Smoe_PRP4 ------------------------------------------------------------
YAK_b_Smoe_YAK ------------------------------------------------------------
YAK_a_Smoe_YAK ------------------------------------------------------------
YAK_d_Smoe_YAK ------------------------------------------------------------
GK031_Glam_DYRK1 ------------------------------------------------------------
GK034_Glam_DYRK2 ------------------------------------------------------------
GK033_Glam_DYRK2 ------------------------------------------------------------
GK032_Glam_DYRK2 ------------------------------------------------------------
PRP4_Hsap_PRP4 ------------------------------------------------------------
HIPK4_Hsap_HIPK ------------------------------------------------------------
HIPK3_Hsap_HIPK ------------------------------------------------------------
HIPK2_Hsap_HIPK ------------------------------------------------------------
HIPK1_Hsap_HIPK ------------------------------------------------------------
smi35A_Dmel_DYRK2 ------------------------------------------------------------
mnb_Dmel_DYRK1 ------------------------------------------------------------
Dyrk3_Dmel_DYRK2 ------------------------------------------------------------
CG17090_Dmel_HIPK ------------------------------------------------------------
PRP4_Mmus_PRP4 ------------------------------------------------------------
HIPK4_Mmus_HIPK ------------------------------------------------------------
HIPK3_Mmus_HIPK ------------------------------------------------------------
HIPK2_Mmus_HIPK ------------------------------------------------------------
HIPK1_Mmus_HIPK ------------------------------------------------------------
DYRK4_Mmus_DYRK2 ------------------------------------------------------------
DYRK3_Mmus_DYRK2 ------------------------------------------------------------
DYRK2_Mmus_DYRK2 ------------------------------------------------------------
DYRK1B_Mmus_DYRK1 ------------------------------------------------------------
DYRK1A_Mmus_DYRK1 ------------------------------------------------------------
mbk-2_Cele_DYRK2 ------------------------------------------------------------
mbk-1_Cele_DYRK1 ------------------------------------------------------------
hpk-1_Cele_HIPK ------------------------------------------------------------
F22D6.5_Cele_PRP4 ------------------------------------------------------------
C36B7.2_Cele_DYRK2 ------------------------------------------------------------
C36B7.1_Cele_DYRK2 ------------------------------------------------------------
DYRK4_Hsap_DYRK2 ------------------------------------------------------------
DYRK3_Hsap_DYRK2 ------------------------------------------------------------
DYRK2_Hsap_DYRK2 ------------------------------------------------------------
DYRK1B_Hsap_DYRK1 ------------------------------------------------------------
DYRK1A_Hsap_DYRK1 ------------------------------------------------------------
YAK1_Scer_YAK ------------------------------------------------------------
Dyrk1_Ddis_DYRK1 ------------------------------------------------------------
Dyrk2_Ddis_DYRK2 ------------------------------------------------------------
Prp4_Ddis_PRP4 ------------------------------------------------------------
YakA_Ddis_YAK ------------------------------------------------------------
22349_Tthe_YAK ------------------------------------------------------------
10580_Tthe_DyrkP ------------------------------------------------------------
22423_Tthe_DyrkP ------------------------------------------------------------
5306_Tthe_DYRK2 ------------------------------------------------------------
5356_Tthe_DYRK2 ------------------------------------------------------------
5655_Tthe_DYRK2 ------------------------------------------------------------
15575_Tthe_PRP4 ------------------------------------------------------------
DYRK1_Spur_DYRK1 ------------------------------------------------------------
DYRK2_Spur_DYRK2 ------------------------------------------------------------
DYRK4_Spur_DYRK2 ------------------------------------------------------------
HIPKa_Spur_HIPK ------------------------------------------------------------
HIPKb_Spur_HIPK ------------------------------------------------------------
PRP4_Spur_PRP4 IPLPKFEPKIPPPPPPPNSRRESGRKERGRGGDDTLAALEKQKELLQAQLLATAEDEHSG
CG7028_Dmel_PRP4 ------------------------------------------------------------
CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------
CC1G_04865_Ccin_PRP4 ------------------------------------------------------------
CC1G_14245_Ccin_YAK ------------------------------------------------------------
AqueK110_Aque_DYRK1 ------------------------------------------------------------
AqueK111_Aque_DYRK1 ------------------------------------------------------------
AqueK112_Aque_DYRK2 ------------------------------------------------------------
AqueK113_Aque_DYRK2 ------------------------------------------------------------
AqueK114_Aque_HIPK ------------------------------------------------------------
AqueK115_Aque_PRP4 ------------------------------------------------------------
AqueK116_Aque_PRP4 ------------------------------------------------------------
DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------
DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------
DYRKP-2_Smoe_DYRKP ------------------------------------------------------------
DYRKP-1_Smoe_DYRKP ------------------------------------------------------------
PRP4_e_Smoe_PRP4 ------------------------------------------------------------
PRP4_d_Smoe_PRP4 ------------------------------------------------------------
PRP4_b_Smoe_PRP4 ------------------------------------------------------------
PRP4_a_Smoe_PRP4 ------------------------------------------------------------
PRP4_c_Smoe_PRP4 ------------------------------------------------------------
YAK_b_Smoe_YAK ------------------------------------------------------------
YAK_a_Smoe_YAK ------------------------------------------------------------
YAK_d_Smoe_YAK ------------------------------------------------------------
GK031_Glam_DYRK1 ------------------------------------------------------------
GK034_Glam_DYRK2 ------------------------------------------------------------
GK033_Glam_DYRK2 ------------------------------------------------------------
GK032_Glam_DYRK2 ------------------------------------------------------------
PRP4_Hsap_PRP4 ------------------------------------------------------------
HIPK4_Hsap_HIPK ------------------------------------------------------------
HIPK3_Hsap_HIPK ------------------------------------------------------------
HIPK2_Hsap_HIPK ------------------------------------------------------------
HIPK1_Hsap_HIPK ------------------------------------------------------------
smi35A_Dmel_DYRK2 ------------------------------------------------------------
mnb_Dmel_DYRK1 ------------------------------------------------------------
Dyrk3_Dmel_DYRK2 ------------------------------------------------------------
CG17090_Dmel_HIPK ------------------------------------------------------------
PRP4_Mmus_PRP4 ------------------------------------------------------------
HIPK4_Mmus_HIPK ------------------------------------------------------------
HIPK3_Mmus_HIPK ------------------------------------------------------------
HIPK2_Mmus_HIPK ------------------------------------------------------------
HIPK1_Mmus_HIPK ------------------------------------------------------------
DYRK4_Mmus_DYRK2 ------------------------------------------------------------
DYRK3_Mmus_DYRK2 ------------------------------------------------------------
DYRK2_Mmus_DYRK2 ------------------------------------------------------------
DYRK1B_Mmus_DYRK1 ------------------------------------------------------------
DYRK1A_Mmus_DYRK1 ------------------------------------------------------------
mbk-2_Cele_DYRK2 ------------------------------------------------------------
mbk-1_Cele_DYRK1 ------------------------------------------------------------
hpk-1_Cele_HIPK ------------------------------------------------------------
F22D6.5_Cele_PRP4 ------------------------------------------------------------
C36B7.2_Cele_DYRK2 ------------------------------------------------------------
C36B7.1_Cele_DYRK2 ------------------------------------------------------------
DYRK4_Hsap_DYRK2 ------------------------------------------------------------
DYRK3_Hsap_DYRK2 ------------------------------------------------------------
DYRK2_Hsap_DYRK2 ------------------------------------------------------------
DYRK1B_Hsap_DYRK1 ------------------------------------------------------------
DYRK1A_Hsap_DYRK1 ------------------------------------------------------------
YAK1_Scer_YAK ------------------------------------------------------------
Dyrk1_Ddis_DYRK1 ------------------------------------------------------------
Dyrk2_Ddis_DYRK2 ------------------------------------------------------------
Prp4_Ddis_PRP4 ------------------------------------------------------------
YakA_Ddis_YAK ------------------------------------------------------------
22349_Tthe_YAK ------------------------------------------------------------
10580_Tthe_DyrkP ------------------------------------------------------------
22423_Tthe_DyrkP ------------------------------------------------------------
5306_Tthe_DYRK2 ------------------------------------------------------------
5356_Tthe_DYRK2 ------------------------------------------------------------
5655_Tthe_DYRK2 ------------------------------------------------------------
15575_Tthe_PRP4 ------------------------------------------------------------
DYRK1_Spur_DYRK1 ------------------------------------------------------------
DYRK2_Spur_DYRK2 ------------------------------------------------------------
DYRK4_Spur_DYRK2 ------------------------------------------------------------
HIPKa_Spur_HIPK ------------------------------------------------------------
HIPKb_Spur_HIPK ------------------------------------------------------------
PRP4_Spur_PRP4 MNLIAQGYQSDEEEGEDDESALKQSLSKWIRPESSSSKPSSKSELKDSERSEKRKRERED
CG7028_Dmel_PRP4 ------------------------------------------------------------
CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------
CC1G_04865_Ccin_PRP4 ------------------------------------------------------------
CC1G_14245_Ccin_YAK ------------------------------------------------------------
AqueK110_Aque_DYRK1 ------------------------------------------------------------
AqueK111_Aque_DYRK1 ------------------------------------------------------------
AqueK112_Aque_DYRK2 ------------------------------------------------------------
AqueK113_Aque_DYRK2 ------------------------------------------------------------
AqueK114_Aque_HIPK ------------------------------------------------------------
AqueK115_Aque_PRP4 ------------------------------------------------------------
AqueK116_Aque_PRP4 ------------------------------------------------------------
DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------
DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------
DYRKP-2_Smoe_DYRKP ------------------------------------------------------------
DYRKP-1_Smoe_DYRKP ------------------------------------------------------------
PRP4_e_Smoe_PRP4 ------------------------------------------------------------
PRP4_d_Smoe_PRP4 ------------------------------------------------------------
PRP4_b_Smoe_PRP4 ------------------------------------------------------------
PRP4_a_Smoe_PRP4 ------------------------------------------------------------
PRP4_c_Smoe_PRP4 ------------------------------------------------------------
YAK_b_Smoe_YAK ------------------------------------------------------------
YAK_a_Smoe_YAK ------------------------------------------------------------
YAK_d_Smoe_YAK ------------------------------------------------------------
GK031_Glam_DYRK1 ------------------------------------------------------------
GK034_Glam_DYRK2 ------------------------------------------------------------
GK033_Glam_DYRK2 ------------------------------------------------------------
GK032_Glam_DYRK2 ------------------------------------------------------------
PRP4_Hsap_PRP4 ------------------------------------------------------------
HIPK4_Hsap_HIPK ------------------------------------------------------------
HIPK3_Hsap_HIPK ------------------------------------------------------------
HIPK2_Hsap_HIPK ------------------------------------------------------------
HIPK1_Hsap_HIPK ------------------------------------------------------------
smi35A_Dmel_DYRK2 ------------------------------------------------------------
mnb_Dmel_DYRK1 ------------------------------------------------------------
Dyrk3_Dmel_DYRK2 ------------------------------------------------------------
CG17090_Dmel_HIPK ------------------------------------------------------------
PRP4_Mmus_PRP4 ------------------------------------------------------------
HIPK4_Mmus_HIPK ------------------------------------------------------------
HIPK3_Mmus_HIPK ------------------------------------------------------------
HIPK2_Mmus_HIPK ------------------------------------------------------------
HIPK1_Mmus_HIPK ------------------------------------------------------------
DYRK4_Mmus_DYRK2 ------------------------------------------------------------
DYRK3_Mmus_DYRK2 ------------------------------------------------------------
DYRK2_Mmus_DYRK2 ------------------------------------------------------------
DYRK1B_Mmus_DYRK1 ------------------------------------------------------------
DYRK1A_Mmus_DYRK1 ------------------------------------------------------------
mbk-2_Cele_DYRK2 ------------------------------------------------------------
mbk-1_Cele_DYRK1 ------------------------------------------------------------
hpk-1_Cele_HIPK ------------------------------------------------------------
F22D6.5_Cele_PRP4 ------------------------------------------------------------
C36B7.2_Cele_DYRK2 ------------------------------------------------------------
C36B7.1_Cele_DYRK2 ------------------------------------------------------------
DYRK4_Hsap_DYRK2 ------------------------------------------------------------
DYRK3_Hsap_DYRK2 ------------------------------------------------------------
DYRK2_Hsap_DYRK2 ------------------------------------------------------------
DYRK1B_Hsap_DYRK1 ------------------------------------------------------------
DYRK1A_Hsap_DYRK1 ------------------------------------------------------------
YAK1_Scer_YAK ------------------------------------------------------------
Dyrk1_Ddis_DYRK1 ------------------------------------------------------------
Dyrk2_Ddis_DYRK2 ------------------------------------------------------------
Prp4_Ddis_PRP4 ------------------------------------------------------------
YakA_Ddis_YAK ------------------------------------------------------------
22349_Tthe_YAK ------------------------------------------------------------
10580_Tthe_DyrkP ------------------------------------------------------------
22423_Tthe_DyrkP ------------------------------------------------------------
5306_Tthe_DYRK2 ------------------------------------------------------------
5356_Tthe_DYRK2 ------------------------------------------------------------
5655_Tthe_DYRK2 ------------------------------------------------------------
15575_Tthe_PRP4 ------------------------------------------------------------
DYRK1_Spur_DYRK1 ------------------------------------------------------------
DYRK2_Spur_DYRK2 ------------------------------------------------------------
DYRK4_Spur_DYRK2 ------------------------------------------------------------
HIPKa_Spur_HIPK ------------------------------------------------------------
HIPKb_Spur_HIPK ------------------------------------------------------------
PRP4_Spur_PRP4 ETSQKKQHRSKSPATERSSGSSRVDNGDAKSSQSRTNRDSHIASDRKHSKDSDSRRDSRK
CG7028_Dmel_PRP4 ------------------------------------------------------------
CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------
CC1G_04865_Ccin_PRP4 ------------------------------------------------------------
CC1G_14245_Ccin_YAK ------------------------------------------------------------
AqueK110_Aque_DYRK1 ------------------------------------------------------------
AqueK111_Aque_DYRK1 ------------------------------------------------------------
AqueK112_Aque_DYRK2 ------------------------------------------------------------
AqueK113_Aque_DYRK2 ------------------------------------------------------------
AqueK114_Aque_HIPK ------------------------------------------------------------
AqueK115_Aque_PRP4 ------------------------------------------------------------
AqueK116_Aque_PRP4 ------------------------------------------------------------
DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------
DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------
DYRKP-2_Smoe_DYRKP ------------------------------------------------------------
DYRKP-1_Smoe_DYRKP ------------------------------------------------------------
PRP4_e_Smoe_PRP4 ------------------------------------------------------------
PRP4_d_Smoe_PRP4 ------------------------------------------------------------
PRP4_b_Smoe_PRP4 ------------------------------------------------------------
PRP4_a_Smoe_PRP4 ------------------------------------------------------------
PRP4_c_Smoe_PRP4 ------------------------------------------------------------
YAK_b_Smoe_YAK ------------------------------------------------------------
YAK_a_Smoe_YAK ------------------------------------------------------------
YAK_d_Smoe_YAK ------------------------------------------------------------
GK031_Glam_DYRK1 ------------------------------------------------------------
GK034_Glam_DYRK2 ------------------------------------------------------------
GK033_Glam_DYRK2 ------------------------------------------------------------
GK032_Glam_DYRK2 ------------------------------------------------------------
PRP4_Hsap_PRP4 ------------------------------------------------------------
HIPK4_Hsap_HIPK ------------------------------------------------------------
HIPK3_Hsap_HIPK ------------------------------------------------------------
HIPK2_Hsap_HIPK ------------------------------------------------------------
HIPK1_Hsap_HIPK ------------------------------------------------------------
smi35A_Dmel_DYRK2 ------------------------------------------------------------
mnb_Dmel_DYRK1 ------------------------------------------------------------
Dyrk3_Dmel_DYRK2 ------------------------------------------------------------
CG17090_Dmel_HIPK ------------------------------------------------------------
PRP4_Mmus_PRP4 ------------------------------------------------------------
HIPK4_Mmus_HIPK ------------------------------------------------------------
HIPK3_Mmus_HIPK ------------------------------------------------------------
HIPK2_Mmus_HIPK ------------------------------------------------------------
HIPK1_Mmus_HIPK ------------------------------------------------------------
DYRK4_Mmus_DYRK2 ------------------------------------------------------------
DYRK3_Mmus_DYRK2 ------------------------------------------------------------
DYRK2_Mmus_DYRK2 ------------------------------------------------------------
DYRK1B_Mmus_DYRK1 ------------------------------------------------------------
DYRK1A_Mmus_DYRK1 ------------------------------------------------------------
mbk-2_Cele_DYRK2 ------------------------------------------------------------
mbk-1_Cele_DYRK1 ------------------------------------------------------------
hpk-1_Cele_HIPK ------------------------------------------------------------
F22D6.5_Cele_PRP4 ------------------------------------------------------------
C36B7.2_Cele_DYRK2 ------------------------------------------------------------
C36B7.1_Cele_DYRK2 ------------------------------------------------------------
DYRK4_Hsap_DYRK2 ------------------------------------------------------------
DYRK3_Hsap_DYRK2 ------------------------------------------------------------
DYRK2_Hsap_DYRK2 ------------------------------------------------------------
DYRK1B_Hsap_DYRK1 ------------------------------------------------------------
DYRK1A_Hsap_DYRK1 ------------------------------------------------------------
YAK1_Scer_YAK ------------------------------------------------------------
Dyrk1_Ddis_DYRK1 ------------------------------------------------------------
Dyrk2_Ddis_DYRK2 ------------------------------------------------------------
Prp4_Ddis_PRP4 ------------------------------------------------------------
YakA_Ddis_YAK ------------------------------------------------------------
22349_Tthe_YAK ------------------------------------------------------------
10580_Tthe_DyrkP ------------------------------------------------------------
22423_Tthe_DyrkP ------------------------------------------------------------
5306_Tthe_DYRK2 ------------------------------------------------------------
5356_Tthe_DYRK2 ------------------------------------------------------------
5655_Tthe_DYRK2 ------------------------------------------------------------
15575_Tthe_PRP4 ------------------------------------------------------------
DYRK1_Spur_DYRK1 ------------------------------------------------------------
DYRK2_Spur_DYRK2 ------------------------------------------------------------
DYRK4_Spur_DYRK2 ------------------------------------------------------------
HIPKa_Spur_HIPK ------------------------------------------------------------
HIPKb_Spur_HIPK ------------------------------------------------------------
PRP4_Spur_PRP4 SSPSATKSEQRESRDSREPRDSRKSSGRDGRASPKRELKSGEKSRRESSRDSKPIRSRSP
CG7028_Dmel_PRP4 ------------------------------------------------------------
CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------
CC1G_04865_Ccin_PRP4 ------------------------------------------------------------
CC1G_14245_Ccin_YAK ------------------------------------------------------------
AqueK110_Aque_DYRK1 ------------------------------------------------------------
AqueK111_Aque_DYRK1 ------------------------------------------------------------
AqueK112_Aque_DYRK2 ------------------------------------------------------------
AqueK113_Aque_DYRK2 ------------------------------------------------------------
AqueK114_Aque_HIPK ------------------------------------------------------------
AqueK115_Aque_PRP4 ------------------------------------------------------------
AqueK116_Aque_PRP4 ------------------------------------------------------------
DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------
DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------
DYRKP-2_Smoe_DYRKP ------------------------------------------------------------
DYRKP-1_Smoe_DYRKP ------------------------------------------------------------
PRP4_e_Smoe_PRP4 ------------------------------------------------------------
PRP4_d_Smoe_PRP4 ------------------------------------------------------------
PRP4_b_Smoe_PRP4 ------------------------------------------------------------
PRP4_a_Smoe_PRP4 -----------------------------GRVDDAKDKSRKRKSVEDEQPSSKRREDDDG
PRP4_c_Smoe_PRP4 ------------------------------------------------------------
YAK_b_Smoe_YAK ------------------------------------------------------------
YAK_a_Smoe_YAK ------------------------------------------------------------
YAK_d_Smoe_YAK ------------------------------------------------------------
GK031_Glam_DYRK1 ------------------------------------------------------------
GK034_Glam_DYRK2 ------------------------------------------------------------
GK033_Glam_DYRK2 ------------------------------------------------------------
GK032_Glam_DYRK2 ------------------------------------------------------------
PRP4_Hsap_PRP4 ------------------------------------------------------------
HIPK4_Hsap_HIPK ------------------------------------------------------------
HIPK3_Hsap_HIPK ------------------------------------------------------------
HIPK2_Hsap_HIPK ------------------------------------------------------------
HIPK1_Hsap_HIPK ------------------------------------------------------------
smi35A_Dmel_DYRK2 ------------------------------------------------------------
mnb_Dmel_DYRK1 ------------------------------------------------------------
Dyrk3_Dmel_DYRK2 ------------------------------------------------------------
CG17090_Dmel_HIPK ------------------------------------------------------------
PRP4_Mmus_PRP4 ------------------------------------------------------------
HIPK4_Mmus_HIPK ------------------------------------------------------------
HIPK3_Mmus_HIPK ------------------------------------------------------------
HIPK2_Mmus_HIPK ------------------------------------------------------------
HIPK1_Mmus_HIPK ------------------------------------------------------------
DYRK4_Mmus_DYRK2 ------------------------------------------------------------
DYRK3_Mmus_DYRK2 ------------------------------------------------------------
DYRK2_Mmus_DYRK2 ------------------------------------------------------------
DYRK1B_Mmus_DYRK1 ------------------------------------------------------------
DYRK1A_Mmus_DYRK1 ------------------------------------------------------------
mbk-2_Cele_DYRK2 ------------------------------------------------------------
mbk-1_Cele_DYRK1 ------------------------------------------------------------
hpk-1_Cele_HIPK ------------------------------------------------------------
F22D6.5_Cele_PRP4 ------------------------------------------------------------
C36B7.2_Cele_DYRK2 ------------------------------------------------------------
C36B7.1_Cele_DYRK2 ------------------------------------------------------------
DYRK4_Hsap_DYRK2 ------------------------------------------------------------
DYRK3_Hsap_DYRK2 ------------------------------------------------------------
DYRK2_Hsap_DYRK2 ------------------------------------------------------------
DYRK1B_Hsap_DYRK1 ------------------------------------------------------------
DYRK1A_Hsap_DYRK1 ------------------------------------------------------------
YAK1_Scer_YAK ------------------------------------------------------------
Dyrk1_Ddis_DYRK1 ------------------------------------------------------------
Dyrk2_Ddis_DYRK2 ------------------------------------------------------------
Prp4_Ddis_PRP4 ------------------------------------------------------------
YakA_Ddis_YAK ------------------------------------------------------------
22349_Tthe_YAK ------------------------------------------------------------
10580_Tthe_DyrkP ------------------------------------------------------------
22423_Tthe_DyrkP ------------------------------------------------------------
5306_Tthe_DYRK2 ------------------------------------------------------------
5356_Tthe_DYRK2 ------------------------------------------------------------
5655_Tthe_DYRK2 ------------------------------------------------------------
15575_Tthe_PRP4 ------------------------------------------------------------
DYRK1_Spur_DYRK1 ------------------------------------------------------------
DYRK2_Spur_DYRK2 ------------------------------------------------------------
DYRK4_Spur_DYRK2 ------------------------------------------------------------
HIPKa_Spur_HIPK ------------------------------------------------------------
HIPKb_Spur_HIPK ------------------------------------------------------------
PRP4_Spur_PRP4 KKERVFTEPARSRPSPPRRSPPPRRPPSPPARRPDQPLGRRGRSPIERRGRSPLERRIRS
CG7028_Dmel_PRP4 ------------------------------------------------------------
CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------
CC1G_04865_Ccin_PRP4 ------------------------------------------------------------
CC1G_14245_Ccin_YAK ------------------------------------------------------------
AqueK110_Aque_DYRK1 ------------------------------------------------------------
AqueK111_Aque_DYRK1 ------------------------------------------------------------
AqueK112_Aque_DYRK2 ------------------------------------------------------------
AqueK113_Aque_DYRK2 ------------------------------------------------------------
AqueK114_Aque_HIPK ------------------------------------------------------------
AqueK115_Aque_PRP4 ------------------------------------------------------------
AqueK116_Aque_PRP4 ------------------------------------------------------------
DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------
DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------
DYRKP-2_Smoe_DYRKP ------------------------------------------------------------
DYRKP-1_Smoe_DYRKP ------------------------------------------------------------
PRP4_e_Smoe_PRP4 ------------------------------------------------------------
PRP4_d_Smoe_PRP4 ------------------------------------------------------------
PRP4_b_Smoe_PRP4 ------------------------------------------------------------
PRP4_a_Smoe_PRP4 KRKHKHRKHKHRSSHRKHISKEVDLDVVPAAMACEAEDGEILEPTEDGIVLKEEGNGSSE
PRP4_c_Smoe_PRP4 ------------------------------------------------------------
YAK_b_Smoe_YAK ------------------------------------------------------------
YAK_a_Smoe_YAK ------------------------------------------------------------
YAK_d_Smoe_YAK ------------------------------------------------------------
GK031_Glam_DYRK1 ------------------------------------------------------------
GK034_Glam_DYRK2 ------------------------------------------------------------
GK033_Glam_DYRK2 ------------------------------------------------------------
GK032_Glam_DYRK2 ------------------------------------------------------------
PRP4_Hsap_PRP4 ------------------------------------------------------------
HIPK4_Hsap_HIPK ------------------------------------------------------------
HIPK3_Hsap_HIPK ------------------------------------------------------------
HIPK2_Hsap_HIPK ------------------------------------------------------------
HIPK1_Hsap_HIPK ------------------------------------------------------------
smi35A_Dmel_DYRK2 ------------------------------------------------------------
mnb_Dmel_DYRK1 ------------------------------------------------------------
Dyrk3_Dmel_DYRK2 ------------------------------------------------------------
CG17090_Dmel_HIPK ------------------------------------------------------------
PRP4_Mmus_PRP4 ------------------------------------------------------------
HIPK4_Mmus_HIPK ------------------------------------------------------------
HIPK3_Mmus_HIPK ------------------------------------------------------------
HIPK2_Mmus_HIPK ------------------------------------------------------------
HIPK1_Mmus_HIPK ------------------------------------------------------------
DYRK4_Mmus_DYRK2 ------------------------------------------------------------
DYRK3_Mmus_DYRK2 ------------------------------------------------------------
DYRK2_Mmus_DYRK2 ------------------------------------------------------------
DYRK1B_Mmus_DYRK1 ------------------------------------------------------------
DYRK1A_Mmus_DYRK1 ------------------------------------------------------------
mbk-2_Cele_DYRK2 ------------------------------------------------------------
mbk-1_Cele_DYRK1 ------------------------------------------------------------
hpk-1_Cele_HIPK ------------------------------------------------------------
F22D6.5_Cele_PRP4 ------------------------------------------------------------
C36B7.2_Cele_DYRK2 ------------------------------------------------------------
C36B7.1_Cele_DYRK2 ------------------------------------------------------------
DYRK4_Hsap_DYRK2 ------------------------------------------------------------
DYRK3_Hsap_DYRK2 ------------------------------------------------------------
DYRK2_Hsap_DYRK2 ------------------------------------------------------------
DYRK1B_Hsap_DYRK1 ------------------------------------------------------------
DYRK1A_Hsap_DYRK1 ------------------------------------------------------------
YAK1_Scer_YAK ------------------------------------------------------------
Dyrk1_Ddis_DYRK1 ------------------------------------------------------------
Dyrk2_Ddis_DYRK2 ------------------------------------------------------------
Prp4_Ddis_PRP4 ------------------------------------------------------------
YakA_Ddis_YAK ------------------------------------------------------------
22349_Tthe_YAK ------------------------------------------------------------
10580_Tthe_DyrkP ------------------------------------------------------------
22423_Tthe_DyrkP ------------------------------------------------------------
5306_Tthe_DYRK2 ------------------------------------------------------------
5356_Tthe_DYRK2 ------------------------------------------------------------
5655_Tthe_DYRK2 ------------------------------------------------------------
15575_Tthe_PRP4 ------------------------------------------------------------
DYRK1_Spur_DYRK1 ------------------------------------------------------------
DYRK2_Spur_DYRK2 ------------------------------------------------------------
DYRK4_Spur_DYRK2 ------------------------------------------------------------
HIPKa_Spur_HIPK ------------------------------------------------------------
HIPKb_Spur_HIPK ------------------------------------------------------------
PRP4_Spur_PRP4 SRSPAVVDRFDRRRGASPPRRFGDMSRNRRRWSRSPDRRGRRGRWGRSRSKSPRDKFKGS
CG7028_Dmel_PRP4 ------------------------------------------------------------
CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------
CC1G_04865_Ccin_PRP4 ------------------------------------------------------------
CC1G_14245_Ccin_YAK ------------------------------------------------------------
AqueK110_Aque_DYRK1 ------------------------------------------------------------
AqueK111_Aque_DYRK1 ------------------------------------------------------------
AqueK112_Aque_DYRK2 ------------------------------------------------------------
AqueK113_Aque_DYRK2 ------------------------------------------------------------
AqueK114_Aque_HIPK ------------------------------------------------------------
AqueK115_Aque_PRP4 ------------------------------------------------------------
AqueK116_Aque_PRP4 ------------------------------------------------------------
DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------
DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------
DYRKP-2_Smoe_DYRKP ------------------------------------------------------------
DYRKP-1_Smoe_DYRKP ------------------------------------------------------------
PRP4_e_Smoe_PRP4 ------------------------------------------------------------
PRP4_d_Smoe_PRP4 ------------------------------------------------------------
PRP4_b_Smoe_PRP4 ------------------------------------------------------------
PRP4_a_Smoe_PRP4 SEKDVEQEIEAPKSERGSPRRSRDGSPPRDNVDRKHSSPDRRHRGSSVDRKRRSRSKESV
PRP4_c_Smoe_PRP4 ------------------------------------------------------------
YAK_b_Smoe_YAK ------------------------------------------------------------
YAK_a_Smoe_YAK ------------------------------------------------------------
YAK_d_Smoe_YAK ------------------------------------------------------------
GK031_Glam_DYRK1 ------------------------------------------------------------
GK034_Glam_DYRK2 ------------------------------------------------------------
GK033_Glam_DYRK2 ------------------------------------------------------------
GK032_Glam_DYRK2 ------------------------------------------------------------
PRP4_Hsap_PRP4 ------------------------------------------------------------
HIPK4_Hsap_HIPK ------------------------------------------------------------
HIPK3_Hsap_HIPK ------------------------------------------------------------
HIPK2_Hsap_HIPK ------------------------------------------------------------
HIPK1_Hsap_HIPK ------------------------------------------------------------
smi35A_Dmel_DYRK2 ------------------------------------------------------------
mnb_Dmel_DYRK1 ------------------------------------------------------------
Dyrk3_Dmel_DYRK2 ------------------------------------------------------------
CG17090_Dmel_HIPK ------------------------------------------------------------
PRP4_Mmus_PRP4 ------------------------------------------------------------
HIPK4_Mmus_HIPK ------------------------------------------------------------
HIPK3_Mmus_HIPK ------------------------------------------------------------
HIPK2_Mmus_HIPK ------------------------------------------------------------
HIPK1_Mmus_HIPK ------------------------------------------------------------
DYRK4_Mmus_DYRK2 ------------------------------------------------------------
DYRK3_Mmus_DYRK2 ------------------------------------------------------------
DYRK2_Mmus_DYRK2 ------------------------------------------------------------
DYRK1B_Mmus_DYRK1 ------------------------------------------------------------
DYRK1A_Mmus_DYRK1 ------------------------------------------------------------
mbk-2_Cele_DYRK2 ------------------------------------------------------------
mbk-1_Cele_DYRK1 ------------------------------------------------------------
hpk-1_Cele_HIPK ------------------------------------------------------------
F22D6.5_Cele_PRP4 ------------------------------------------------------------
C36B7.2_Cele_DYRK2 ------------------------------------------------------------
C36B7.1_Cele_DYRK2 ------------------------------------------------------------
DYRK4_Hsap_DYRK2 ------------------------------------------------------------
DYRK3_Hsap_DYRK2 ------------------------------------------------------------
DYRK2_Hsap_DYRK2 ------------------------------------------------------------
DYRK1B_Hsap_DYRK1 ------------------------------------------------------------
DYRK1A_Hsap_DYRK1 ------------------------------------------------------------
YAK1_Scer_YAK ------------------------------------------------------------
Dyrk1_Ddis_DYRK1 ------------------------------------------------------------
Dyrk2_Ddis_DYRK2 ------------------------------------------------------------
Prp4_Ddis_PRP4 ------------------------------------------------------------
YakA_Ddis_YAK ------------------------------------------------------------
22349_Tthe_YAK ------------------------------------------------------------
10580_Tthe_DyrkP ------------------------------------------------------------
22423_Tthe_DyrkP ------------------------------------------------------------
5306_Tthe_DYRK2 ------------------------------------------------------------
5356_Tthe_DYRK2 ------------------------------------------------------------
5655_Tthe_DYRK2 ------------------------------------------------------------
15575_Tthe_PRP4 ------------------------------------------------------------
DYRK1_Spur_DYRK1 ------------------------------------------------------------
DYRK2_Spur_DYRK2 ------------------------------------------------------------
DYRK4_Spur_DYRK2 ------------------------------------------------------------
HIPKa_Spur_HIPK ------------------------------------------------------------
HIPKb_Spur_HIPK ------------------------------------------------------------
PRP4_Spur_PRP4 LSEGLSLKQESSDDEIPDVDLDEEEDEEAVIERRRRERQQLMQKYKVAPAESATSSPAQG
CG7028_Dmel_PRP4 ------------------------------------------------------------
CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------
CC1G_04865_Ccin_PRP4 ------------------------------------------------------------
CC1G_14245_Ccin_YAK ------------------------------------------------------------
AqueK110_Aque_DYRK1 ------------------------------------------------------------
AqueK111_Aque_DYRK1 ------------------------------------------------------------
AqueK112_Aque_DYRK2 ------------------------------------------------------------
AqueK113_Aque_DYRK2 ------------------------------------------------------------
AqueK114_Aque_HIPK ------------------------------------------------------------
AqueK115_Aque_PRP4 ------------------------------------------------------------
AqueK116_Aque_PRP4 ------------------------------------------------------------
DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------
DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------
DYRKP-2_Smoe_DYRKP ------------------------------------------------------------
DYRKP-1_Smoe_DYRKP ------------------------------------------------------------
PRP4_e_Smoe_PRP4 ------------------------------------------------------------
PRP4_d_Smoe_PRP4 ------------------------------------------------------------
PRP4_b_Smoe_PRP4 ------------------------------------------------------------
PRP4_a_Smoe_PRP4 RENARHHSRVASPDRKRRRSRSRDRGDERSRRHAYSPDRRRRSRSREHDEREKYPRKRAE
PRP4_c_Smoe_PRP4 ------------------------------------------------------------
YAK_b_Smoe_YAK ------------------------------------------------------------
YAK_a_Smoe_YAK ------------------------------------------------------------
YAK_d_Smoe_YAK ------------------------------------------------------------
GK031_Glam_DYRK1 ------------------------------------------------------------
GK034_Glam_DYRK2 ------------------------------------------------------------
GK033_Glam_DYRK2 ------------------------------------------------------------
GK032_Glam_DYRK2 ------------------------------------------------------------
PRP4_Hsap_PRP4 ------------------------------------------------------------
HIPK4_Hsap_HIPK ------------------------------------------------------------
HIPK3_Hsap_HIPK ------------------------------------------------------------
HIPK2_Hsap_HIPK ------------------------------------------------------------
HIPK1_Hsap_HIPK ------------------------------------------------------------
smi35A_Dmel_DYRK2 ------------------------------------------------------------
mnb_Dmel_DYRK1 ------------------------------------------------------------
Dyrk3_Dmel_DYRK2 ------------------------------------------------------------
CG17090_Dmel_HIPK ------------------------------------------------------------
PRP4_Mmus_PRP4 ------------------------------------------------------------
HIPK4_Mmus_HIPK ------------------------------------------------------------
HIPK3_Mmus_HIPK ------------------------------------------------------------
HIPK2_Mmus_HIPK ------------------------------------------------------------
HIPK1_Mmus_HIPK ------------------------------------------------------------
DYRK4_Mmus_DYRK2 ------------------------------------------------------------
DYRK3_Mmus_DYRK2 ------------------------------------------------------------
DYRK2_Mmus_DYRK2 ------------------------------------------------------------
DYRK1B_Mmus_DYRK1 ------------------------------------------------------------
DYRK1A_Mmus_DYRK1 ------------------------------------------------------------
mbk-2_Cele_DYRK2 ------------------------------------------------------------
mbk-1_Cele_DYRK1 ------------------------------------------------------------
hpk-1_Cele_HIPK ------------------------------------------------------------
F22D6.5_Cele_PRP4 ------------------------------------------------------------
C36B7.2_Cele_DYRK2 ------------------------------------------------------------
C36B7.1_Cele_DYRK2 ------------------------------------------------------------
DYRK4_Hsap_DYRK2 ------------------------------------------------------------
DYRK3_Hsap_DYRK2 ------------------------------------------------------------
DYRK2_Hsap_DYRK2 ------------------------------------------------------------
DYRK1B_Hsap_DYRK1 ------------------------------------------------------------
DYRK1A_Hsap_DYRK1 ------------------------------------------------------------
YAK1_Scer_YAK ------------------------------------------------------------
Dyrk1_Ddis_DYRK1 ------------------------------------------------------------
Dyrk2_Ddis_DYRK2 ------------------------------------------------------------
Prp4_Ddis_PRP4 ------------------------------------------------------------
YakA_Ddis_YAK ------------------------------------------------------------
22349_Tthe_YAK ------------------------------------------------------------
10580_Tthe_DyrkP ------------------------------------------------------------
22423_Tthe_DyrkP ------------------------------------------------------------
5306_Tthe_DYRK2 ------------------------------------------------------------
5356_Tthe_DYRK2 ------------------------------------------------------------
5655_Tthe_DYRK2 ------------------------------------------------------------
15575_Tthe_PRP4 ------------------------------------------------------------
DYRK1_Spur_DYRK1 ------------------------------------------------------------
DYRK2_Spur_DYRK2 ------------------------------------------------------------
DYRK4_Spur_DYRK2 ------------------------------------------------------------
HIPKa_Spur_HIPK ------------------------------------------------------------
HIPKb_Spur_HIPK ------------------------------------------------------------
PRP4_Spur_PRP4 PSEPSSTPQSPQASEQGGSTAQSQDTDDEDDDEEEEEEDEEEDDSEKSSSSDSDDDSSEV
CG7028_Dmel_PRP4 ------------------------------------------------------------
CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------
CC1G_04865_Ccin_PRP4 ------------------------------------------------------------
CC1G_14245_Ccin_YAK ------------------------------------------------------------
AqueK110_Aque_DYRK1 ------------------------------------------------------------
AqueK111_Aque_DYRK1 ------------------------------------------------------------
AqueK112_Aque_DYRK2 ------------------------------------------------------------
AqueK113_Aque_DYRK2 ------------------------------------------------------------
AqueK114_Aque_HIPK ------------------------------------------------------------
AqueK115_Aque_PRP4 ------------------------------------------------------------
AqueK116_Aque_PRP4 ------------------------------------------------------------
DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------
DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------
DYRKP-2_Smoe_DYRKP ------------------------------------------------------------
DYRKP-1_Smoe_DYRKP ------------------------------------------------------------
PRP4_e_Smoe_PRP4 ------------------------------------------------------------
PRP4_d_Smoe_PRP4 ------------------------------------------------------------
PRP4_b_Smoe_PRP4 ------------------------------------------------------------
PRP4_a_Smoe_PRP4 SRDRHIKDDRGARDDERHYNRDRNRRDREELSEKQETTQSETIEREEENQDEYLERVAHQ
PRP4_c_Smoe_PRP4 ------------------------------------------------------------
YAK_b_Smoe_YAK ------------------------------------------------------------
YAK_a_Smoe_YAK ------------------------------------------------------------
YAK_d_Smoe_YAK ------------------------------------------------------------
GK031_Glam_DYRK1 ------------------------------------------------------------
GK034_Glam_DYRK2 ------------------------------------------------------------
GK033_Glam_DYRK2 ------------------------------------------------------------
GK032_Glam_DYRK2 ------------------------------------------------------------
PRP4_Hsap_PRP4 ------------------------------------------------------------
HIPK4_Hsap_HIPK ------------------------------------------------------------
HIPK3_Hsap_HIPK ------------------------------------------------------------
HIPK2_Hsap_HIPK ------------------------------------------------------------
HIPK1_Hsap_HIPK ------------------------------------------------------------
smi35A_Dmel_DYRK2 ------------------------------------------------------------
mnb_Dmel_DYRK1 ------------------------------------------------------------
Dyrk3_Dmel_DYRK2 ------------------------------------------------------------
CG17090_Dmel_HIPK ------------------------------------------------------------
PRP4_Mmus_PRP4 ------------------------------------------------------------
HIPK4_Mmus_HIPK ------------------------------------------------------------
HIPK3_Mmus_HIPK ------------------------------------------------------------
HIPK2_Mmus_HIPK ------------------------------------------------------------
HIPK1_Mmus_HIPK ------------------------------------------------------------
DYRK4_Mmus_DYRK2 ------------------------------------------------------------
DYRK3_Mmus_DYRK2 ------------------------------------------------------------
DYRK2_Mmus_DYRK2 ------------------------------------------------------------
DYRK1B_Mmus_DYRK1 ------------------------------------------------------------
DYRK1A_Mmus_DYRK1 ------------------------------------------------------------
mbk-2_Cele_DYRK2 ------------------------------------------------------------
mbk-1_Cele_DYRK1 ------------------------------------------------------------
hpk-1_Cele_HIPK ------------------------------------------------------------
F22D6.5_Cele_PRP4 ------------------------------------------------------------
C36B7.2_Cele_DYRK2 ------------------------------------------------------------
C36B7.1_Cele_DYRK2 ------------------------------------------------------------
DYRK4_Hsap_DYRK2 ------------------------------------------------------------
DYRK3_Hsap_DYRK2 ------------------------------------------------------------
DYRK2_Hsap_DYRK2 ------------------------------------------------------------
DYRK1B_Hsap_DYRK1 ------------------------------------------------------------
DYRK1A_Hsap_DYRK1 ------------------------------------------------------------
YAK1_Scer_YAK ------------------------------------------------------------
Dyrk1_Ddis_DYRK1 ------------------------------------------------------------
Dyrk2_Ddis_DYRK2 ------------------------------------------------------------
Prp4_Ddis_PRP4 ------------------------------------------------------------
YakA_Ddis_YAK ------------------------------------------------------------
22349_Tthe_YAK ------------------------------------------------------------
10580_Tthe_DyrkP ------------------------------------------------------------
22423_Tthe_DyrkP ------------------------------------------------------------
5306_Tthe_DYRK2 ------------------------------------------------------------
5356_Tthe_DYRK2 ------------------------------------------------------------
5655_Tthe_DYRK2 ------------------------------------------------------------
15575_Tthe_PRP4 ------------------------------------------------------------
DYRK1_Spur_DYRK1 ------------------------------------------------------------
DYRK2_Spur_DYRK2 ------------------------------------------------------------
DYRK4_Spur_DYRK2 ------------------------------------------------------------
HIPKa_Spur_HIPK ------------------------------------------------------------
HIPKb_Spur_HIPK ------------------------------------------------------------
PRP4_Spur_PRP4 ESKASSDDDDDDEEDDEGDAARIEEEERLREEEEEAEQEKRREMERKRLKEAFPQSDSED
CG7028_Dmel_PRP4 ------------------------------------------------------------
CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------
CC1G_04865_Ccin_PRP4 ------------------------------------------------------------
CC1G_14245_Ccin_YAK ------------------------------------------------------------
AqueK110_Aque_DYRK1 ------------------------------------------------------------
AqueK111_Aque_DYRK1 ------------------------------------------------------------
AqueK112_Aque_DYRK2 ------------------------------------------------------------
AqueK113_Aque_DYRK2 ------------------------------------------------------------
AqueK114_Aque_HIPK ------------------------------------------------------------
AqueK115_Aque_PRP4 ------------------------------------------------------------
AqueK116_Aque_PRP4 ------------------------------------------------------------
DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------
DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------
DYRKP-2_Smoe_DYRKP ------------------------------------------------------------
DYRKP-1_Smoe_DYRKP ------------------------------------------------------------
PRP4_e_Smoe_PRP4 ------------------------------------------------------------
PRP4_d_Smoe_PRP4 ------------------------------------------------------------
PRP4_b_Smoe_PRP4 ------------------------------------------------------------
PRP4_a_Smoe_PRP4 LAEQEEDIEKVKEESRKRRQAILEKHKMQQSQPEEPAETMKVSKPLTAAEPDSGEGIIDP
PRP4_c_Smoe_PRP4 ------------------------------------------------------------
YAK_b_Smoe_YAK ------------------------------------------------------------
YAK_a_Smoe_YAK ------------------------------------------------------------
YAK_d_Smoe_YAK ------------------------------------------------------------
GK031_Glam_DYRK1 ------------------------------------------------------------
GK034_Glam_DYRK2 ------------------------------------------------------------
GK033_Glam_DYRK2 ------------------------------------------------------------
GK032_Glam_DYRK2 ------------------------------------------------------------
PRP4_Hsap_PRP4 ------------------------------------------------------------
HIPK4_Hsap_HIPK ------------------------------------------------------------
HIPK3_Hsap_HIPK ------------------------------------------------------------
HIPK2_Hsap_HIPK ------------------------------------------------------------
HIPK1_Hsap_HIPK ------------------------------------------------------------
smi35A_Dmel_DYRK2 ------------------------------------------------------------
mnb_Dmel_DYRK1 ------------------------------------------------------------
Dyrk3_Dmel_DYRK2 ------------------------------------------------------------
CG17090_Dmel_HIPK ------------------------------------------------------------
PRP4_Mmus_PRP4 ------------------------------------------------------------
HIPK4_Mmus_HIPK ------------------------------------------------------------
HIPK3_Mmus_HIPK ------------------------------------------------------------
HIPK2_Mmus_HIPK ------------------------------------------------------------
HIPK1_Mmus_HIPK ------------------------------------------------------------
DYRK4_Mmus_DYRK2 ------------------------------------------------------------
DYRK3_Mmus_DYRK2 ------------------------------------------------------------
DYRK2_Mmus_DYRK2 ------------------------------------------------------------
DYRK1B_Mmus_DYRK1 ------------------------------------------------------------
DYRK1A_Mmus_DYRK1 ------------------------------------------------------------
mbk-2_Cele_DYRK2 ------------------------------------------------------------
mbk-1_Cele_DYRK1 ------------------------------------------------------------
hpk-1_Cele_HIPK ------------------------------------------------------------
F22D6.5_Cele_PRP4 ------------------------------------------------------------
C36B7.2_Cele_DYRK2 ------------------------------------------------------------
C36B7.1_Cele_DYRK2 ------------------------------------------------------------
DYRK4_Hsap_DYRK2 ------------------------------------------------------------
DYRK3_Hsap_DYRK2 ------------------------------------------------------------
DYRK2_Hsap_DYRK2 ------------------------------------------------------------
DYRK1B_Hsap_DYRK1 ------------------------------------------------------------
DYRK1A_Hsap_DYRK1 ------------------------------------------------------------
YAK1_Scer_YAK ------------------------------------------------------------
Dyrk1_Ddis_DYRK1 ------------------------------------------------------------
Dyrk2_Ddis_DYRK2 ------------------------------------------------------------
Prp4_Ddis_PRP4 ------------------------------------------------------------
YakA_Ddis_YAK ------------------------------------------------------------
22349_Tthe_YAK ------------------------------------------------------------
10580_Tthe_DyrkP ------------------------------------------------------------
22423_Tthe_DyrkP ------------------------------------------------------------
5306_Tthe_DYRK2 ------------------------------------------------------------
5356_Tthe_DYRK2 ------------------------------------------------------------
5655_Tthe_DYRK2 ------------------------------------------------------------
15575_Tthe_PRP4 ------------------------------------------------------------
DYRK1_Spur_DYRK1 ------------------------------------------------------------
DYRK2_Spur_DYRK2 ------------------------------------------------------------
DYRK4_Spur_DYRK2 ------------------------------------------------------------
HIPKa_Spur_HIPK ------------------------------------------------------------
HIPKb_Spur_HIPK ------------------------------------------------------------
PRP4_Spur_PRP4 EESAANSKKGEGSLDKNLSDIVKPKSDKEQAMANNGLDMFSEVDMFKMSPSTREGIGQMG
CG7028_Dmel_PRP4 ------------------------------------------------------------
CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------
CC1G_04865_Ccin_PRP4 ------------------------------------------------------------
CC1G_14245_Ccin_YAK ------------------------------------------------------------
AqueK110_Aque_DYRK1 ------------------------------------------------------------
AqueK111_Aque_DYRK1 ------------------------------------------------------------
AqueK112_Aque_DYRK2 ------------------------------------------------------------
AqueK113_Aque_DYRK2 ------------------------------------------------------------
AqueK114_Aque_HIPK ------------------------------------------------------------
AqueK115_Aque_PRP4 ------------------------------------------------------------
AqueK116_Aque_PRP4 ------------------------------------------------------------
DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------
DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------
DYRKP-2_Smoe_DYRKP ------------------------------------------------------------
DYRKP-1_Smoe_DYRKP ------------------------------------------------------------
PRP4_e_Smoe_PRP4 ------------------------------------------------------------
PRP4_d_Smoe_PRP4 ------------------------------------------------------------
PRP4_b_Smoe_PRP4 ------------------------------------------------------------
PRP4_a_Smoe_PRP4 STPLSLGKSALPNGTILKRNAGGLGEGSPPKSEKPADMFCDIFGESPAEIRKAGTRDTLA
PRP4_c_Smoe_PRP4 ------------------------------------------------------------
YAK_b_Smoe_YAK ------------------------------------------------------------
YAK_a_Smoe_YAK ------------------------------------------------------------
YAK_d_Smoe_YAK ------------------------------------------------------------
GK031_Glam_DYRK1 ------------------------------------------------------------
GK034_Glam_DYRK2 ------------------------------------------------------------
GK033_Glam_DYRK2 ------------------------------------------------------------
GK032_Glam_DYRK2 ------------------------------------------------------------
PRP4_Hsap_PRP4 ------------------------------------------------------------
HIPK4_Hsap_HIPK ------------------------------------------------------------
HIPK3_Hsap_HIPK ------------------------------------------------------------
HIPK2_Hsap_HIPK ------------------------------------------------------------
HIPK1_Hsap_HIPK ------------------------------------------------------------
smi35A_Dmel_DYRK2 ------------------------------------------------------------
mnb_Dmel_DYRK1 ------------------------------------------------------------
Dyrk3_Dmel_DYRK2 ------------------------------------------------------------
CG17090_Dmel_HIPK ------------------------------------------------------------
PRP4_Mmus_PRP4 ------------------------------------------------------------
HIPK4_Mmus_HIPK ------------------------------------------------------------
HIPK3_Mmus_HIPK ------------------------------------------------------------
HIPK2_Mmus_HIPK ------------------------------------------------------------
HIPK1_Mmus_HIPK ------------------------------------------------------------
DYRK4_Mmus_DYRK2 ------------------------------------------------------------
DYRK3_Mmus_DYRK2 ------------------------------------------------------------
DYRK2_Mmus_DYRK2 ------------------------------------------------------------
DYRK1B_Mmus_DYRK1 ------------------------------------------------------------
DYRK1A_Mmus_DYRK1 ------------------------------------------------------------
mbk-2_Cele_DYRK2 ------------------------------------------------------------
mbk-1_Cele_DYRK1 ------------------------------------------------------------
hpk-1_Cele_HIPK ------------------------------------------------------------
F22D6.5_Cele_PRP4 ------------------------------------------------------------
C36B7.2_Cele_DYRK2 ------------------------------------------------------------
C36B7.1_Cele_DYRK2 ------------------------------------------------------------
DYRK4_Hsap_DYRK2 ------------------------------------------------------------
DYRK3_Hsap_DYRK2 ------------------------------------------------------------
DYRK2_Hsap_DYRK2 ------------------------------------------------------------
DYRK1B_Hsap_DYRK1 ------------------------------------------------------------
DYRK1A_Hsap_DYRK1 ------------------------------------------------------------
YAK1_Scer_YAK ------------------------------------------------------------
Dyrk1_Ddis_DYRK1 ------------------------------------------------------------
Dyrk2_Ddis_DYRK2 ------------------------------------------------------------
Prp4_Ddis_PRP4 ------------------------------------------------------------
YakA_Ddis_YAK ------------------------------------------------------------
22349_Tthe_YAK ------------------------------------------------------------
10580_Tthe_DyrkP ------------------------------------------------------------
22423_Tthe_DyrkP ------------------------------------------------------------
5306_Tthe_DYRK2 ------------------------------------------------------------
5356_Tthe_DYRK2 ------------------------------------------------------------
5655_Tthe_DYRK2 ------------------------------------------------------------
15575_Tthe_PRP4 --------------------KKKEDGELSGEEDEYKSPKQKKSDKDDRKKSKRSSRSHSS
DYRK1_Spur_DYRK1 ------------------------------------------------------------
DYRK2_Spur_DYRK2 ------------------------------------------------------------
DYRK4_Spur_DYRK2 ------------------------------------------------------------
HIPKa_Spur_HIPK ------------------------------------------------------------
HIPKb_Spur_HIPK ------------------------------------------------------------
PRP4_Spur_PRP4 PENPSLTDNWDDEEGYYRVRI---------------------------------------
CG7028_Dmel_PRP4 ------------------------------------------------------------
CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------
CC1G_04865_Ccin_PRP4 ------------------------------------------------------------
CC1G_14245_Ccin_YAK ------------------------------------------------------------
AqueK110_Aque_DYRK1 ------------------------------------------------------------
AqueK111_Aque_DYRK1 ------------------------------------------------------------
AqueK112_Aque_DYRK2 ------------------------------------------------------------
AqueK113_Aque_DYRK2 ------------------------------------------------------------
AqueK114_Aque_HIPK ------------------------------------------------------------
AqueK115_Aque_PRP4 ------------------------------------------------------------
AqueK116_Aque_PRP4 ------------------------------------------------------------
DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------
DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------
DYRKP-2_Smoe_DYRKP ------------------------------------------------------------
DYRKP-1_Smoe_DYRKP ------VHPLDELGFSQGRKSSQTHNDQKHKGAARHKSMEARSERSGPESTDEPQVSNIR
PRP4_e_Smoe_PRP4 ------------------------------------------------------------
PRP4_d_Smoe_PRP4 ------------------------------------------------------------
PRP4_b_Smoe_PRP4 ------------------------------------------------------------
PRP4_a_Smoe_PRP4 IDTSGLTDNWDDADGYYTYRV---------------------------------------
PRP4_c_Smoe_PRP4 ------------------------------------------------------------
YAK_b_Smoe_YAK ------------------------------------------------------------
YAK_a_Smoe_YAK ------------------------------------------------------------
YAK_d_Smoe_YAK ------------------------------------------------------------
GK031_Glam_DYRK1 ------------------------------------------------------------
GK034_Glam_DYRK2 ------------------------------------------------------------
GK033_Glam_DYRK2 ------------------------------------------------------------
GK032_Glam_DYRK2 ------------------------------------------------------------
PRP4_Hsap_PRP4 ------------------------------------------------------------
HIPK4_Hsap_HIPK ------------------------------------------------------------
HIPK3_Hsap_HIPK ------------------------------------------------------------
HIPK2_Hsap_HIPK ------------------------------------------------------------
HIPK1_Hsap_HIPK ------------------------------------------------------------
smi35A_Dmel_DYRK2 ------------------------------------------------------------
mnb_Dmel_DYRK1 ------------------------------------------------------------
Dyrk3_Dmel_DYRK2 ------------------------------------------------------------
CG17090_Dmel_HIPK ------------------------------------------------------------
PRP4_Mmus_PRP4 ------------------------------------------------------------
HIPK4_Mmus_HIPK ------------------------------------------------------------
HIPK3_Mmus_HIPK ------------------------------------------------------------
HIPK2_Mmus_HIPK ------------------------------------------------------------
HIPK1_Mmus_HIPK ------------------------------------------------------------
DYRK4_Mmus_DYRK2 ------------------------------------------------------------
DYRK3_Mmus_DYRK2 ------------------------------------------------------------
DYRK2_Mmus_DYRK2 ------------------------------------------------------------
DYRK1B_Mmus_DYRK1 ------------------------------------------------------------
DYRK1A_Mmus_DYRK1 ------------------------------------------------------------
mbk-2_Cele_DYRK2 ------------------------------------------------------------
mbk-1_Cele_DYRK1 ------------------------------------------------------------
hpk-1_Cele_HIPK ------------------------------------------------------------
F22D6.5_Cele_PRP4 ------------------------------------------------------------
C36B7.2_Cele_DYRK2 ------------------------------------------------------------
C36B7.1_Cele_DYRK2 ------------------------------------------------------------
DYRK4_Hsap_DYRK2 ------------------------------------------------------------
DYRK3_Hsap_DYRK2 ------------------------------------------------------------
DYRK2_Hsap_DYRK2 ------------------------------------------------------------
DYRK1B_Hsap_DYRK1 ------------------------------------------------------------
DYRK1A_Hsap_DYRK1 ------------------------------------------------------------
YAK1_Scer_YAK ------------------------------------------------------------
Dyrk1_Ddis_DYRK1 ------------------------------------------------------------
Dyrk2_Ddis_DYRK2 ------------------------------------------------------------
Prp4_Ddis_PRP4 ------------------------------------------------------------
YakA_Ddis_YAK ------------------------------------------------------------
22349_Tthe_YAK ------------------------------------------------------------
10580_Tthe_DyrkP ------------------------------------------------------------
22423_Tthe_DyrkP ------------------------------------------------------------
5306_Tthe_DYRK2 ------------------------------------------------------------
5356_Tthe_DYRK2 ------------------------------------------------------------
5655_Tthe_DYRK2 ------------------------------------------------------------
15575_Tthe_PRP4 RRTNDKISDSTKSNKKDKDHKDSSRRRSKSRSKDRKDQQKRKYSRSRSRSYPNDRNGTKQ
DYRK1_Spur_DYRK1 ------------------------------------------------------------
DYRK2_Spur_DYRK2 ------------------------------------------------------------
DYRK4_Spur_DYRK2 ------------------------------------------------------------
HIPKa_Spur_HIPK ------------------------------------------------------------
HIPKb_Spur_HIPK ------------------------------------------------------------
PRP4_Spur_PRP4 ------------------------------------------------------------
CG7028_Dmel_PRP4 ------------------------------------------------------------
CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------
CC1G_04865_Ccin_PRP4 ------------------------------------------------------------
CC1G_14245_Ccin_YAK ------------------------------------------------------------
AqueK110_Aque_DYRK1 ------------------------------------------------------------
AqueK111_Aque_DYRK1 ------------------------------------------------------------
AqueK112_Aque_DYRK2 ------------------------------------------------------------
AqueK113_Aque_DYRK2 ------------------------------------------------------------
AqueK114_Aque_HIPK ------------------------------------------------------------
AqueK115_Aque_PRP4 ------------------------------------------------------------
AqueK116_Aque_PRP4 ------------------------------------------------------------
DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------
DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------
DYRKP-2_Smoe_DYRKP ------------------------------------------------------------
DYRKP-1_Smoe_DYRKP STRKEAAEDGKPEESCLASRPTSSANSSNQKGGQDKARGSGDGSERSSGFPRLPPVRLKS
PRP4_e_Smoe_PRP4 ------------------------------------------------------------
PRP4_d_Smoe_PRP4 ------------------------------------------------------------
PRP4_b_Smoe_PRP4 ------------------------------------------------------------
PRP4_a_Smoe_PRP4 ------------------------------------------------------------
PRP4_c_Smoe_PRP4 ------------------------------------------------------------
YAK_b_Smoe_YAK ------------------------------------------------------------
YAK_a_Smoe_YAK ------------------------------------------------------------
YAK_d_Smoe_YAK ------------------------------------------------------------
GK031_Glam_DYRK1 ------------------------------------------------------------
GK034_Glam_DYRK2 ------------------------------------------------------------
GK033_Glam_DYRK2 ------------------------------------------------------------
GK032_Glam_DYRK2 ------------------------------------------------------------
PRP4_Hsap_PRP4 ------------------------------------------------------------
HIPK4_Hsap_HIPK ------------------------------------------------------------
HIPK3_Hsap_HIPK ------------------------------------------------------------
HIPK2_Hsap_HIPK ------------------------------------------------------------
HIPK1_Hsap_HIPK ------------------------------------------------------------
smi35A_Dmel_DYRK2 ------------------------------------------------------------
mnb_Dmel_DYRK1 ------------------------------------------------------------
Dyrk3_Dmel_DYRK2 ------------------------------------------------------------
CG17090_Dmel_HIPK ------------------------------------------------------------
PRP4_Mmus_PRP4 ------------------------------------------------------------
HIPK4_Mmus_HIPK ------------------------------------------------------------
HIPK3_Mmus_HIPK ------------------------------------------------------------
HIPK2_Mmus_HIPK ------------------------------------------------------------
HIPK1_Mmus_HIPK ------------------------------------------------------------
DYRK4_Mmus_DYRK2 ------------------------------------------------------------
DYRK3_Mmus_DYRK2 ------------------------------------------------------------
DYRK2_Mmus_DYRK2 ------------------------------------------------------------
DYRK1B_Mmus_DYRK1 ------------------------------------------------------------
DYRK1A_Mmus_DYRK1 ------------------------------------------------------------
mbk-2_Cele_DYRK2 ------------------------------------------------------------
mbk-1_Cele_DYRK1 ------------------------------------------------------------
hpk-1_Cele_HIPK ------------------------------------------------------------
F22D6.5_Cele_PRP4 ------------------------------------------------------------
C36B7.2_Cele_DYRK2 ------------------------------------------------------------
C36B7.1_Cele_DYRK2 ------------------------------------------------------------
DYRK4_Hsap_DYRK2 ------------------------------------------------------------
DYRK3_Hsap_DYRK2 ------------------------------------------------------------
DYRK2_Hsap_DYRK2 ------------------------------------------------------------
DYRK1B_Hsap_DYRK1 ------------------------------------------------------------
DYRK1A_Hsap_DYRK1 ------------------------------------------------------------
YAK1_Scer_YAK ------------------------------------------------------------
Dyrk1_Ddis_DYRK1 ------------------------------------------------------------
Dyrk2_Ddis_DYRK2 ------------------------------------------------------------
Prp4_Ddis_PRP4 ------------------------------------------------------------
YakA_Ddis_YAK ------------------------------------------------------------
22349_Tthe_YAK ------------------------------------------------------------
10580_Tthe_DyrkP ------------------------------------------------------------
22423_Tthe_DyrkP ------------------------------------------------------------
5306_Tthe_DYRK2 ------------------------------------------------------------
5356_Tthe_DYRK2 ------------------------------------------------------------
5655_Tthe_DYRK2 ------------------------------------------------------------
15575_Tthe_PRP4 RHLDNLYQRTQIKNGKCNQIYGSQKRNTKFSNDKFLFSNSKNLSEAFYIDSYFYSLNSSK
DYRK1_Spur_DYRK1 ------------------------------------------------------------
DYRK2_Spur_DYRK2 ------------------------------------------------------------
DYRK4_Spur_DYRK2 ------------------------------------------------------------
HIPKa_Spur_HIPK ------------------------------------------------------------
HIPKb_Spur_HIPK ------------------------------------------------------------
PRP4_Spur_PRP4 ------------------------------------------------------------
CG7028_Dmel_PRP4 ------------------------------------------------------------
CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------
CC1G_04865_Ccin_PRP4 ------------------------------------------------------------
CC1G_14245_Ccin_YAK ------------------------------------------------------------
AqueK110_Aque_DYRK1 ------------------------------------------------------------
AqueK111_Aque_DYRK1 ------------------------------------------------------------
AqueK112_Aque_DYRK2 ------------------------------------------------------------
AqueK113_Aque_DYRK2 ------------------------------------------------------------
AqueK114_Aque_HIPK ------------------------------------------------------------
AqueK115_Aque_PRP4 ------------------------------------------------------------
AqueK116_Aque_PRP4 ------------------------------------------------------------
DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------
DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------
DYRKP-2_Smoe_DYRKP ------------------------------------------------------------
DYRKP-1_Smoe_DYRKP VEKIPDEWVAHCRVGSDADVEMDPLDASSFALGSFLDVPVGQDILSSGTKRCAAINRPSV
PRP4_e_Smoe_PRP4 ------------------------------------------------------------
PRP4_d_Smoe_PRP4 ------------------------------------------------------------
PRP4_b_Smoe_PRP4 ------------------------------------------------------------
PRP4_a_Smoe_PRP4 ------------------------------------------------------------
PRP4_c_Smoe_PRP4 ------------------------------------------------------------
YAK_b_Smoe_YAK ------------------------------------------------------------
YAK_a_Smoe_YAK ------------------------------------------------------------
YAK_d_Smoe_YAK ------------------------------------------------------------
GK031_Glam_DYRK1 ------------------------------------------------------------
GK034_Glam_DYRK2 ------------------------------------------------------------
GK033_Glam_DYRK2 ------------------------------------------------------------
GK032_Glam_DYRK2 ------------------------------------------------------------
PRP4_Hsap_PRP4 ------------------------------------------------------------
HIPK4_Hsap_HIPK ------------------------------------------------------------
HIPK3_Hsap_HIPK ------------------------------------------------------------
HIPK2_Hsap_HIPK ------------------------------------------------------------
HIPK1_Hsap_HIPK ------------------------------------------------------------
smi35A_Dmel_DYRK2 ------------------------------------------------------------
mnb_Dmel_DYRK1 ------------------------------------------------------------
Dyrk3_Dmel_DYRK2 ------------------------------------------------------------
CG17090_Dmel_HIPK ------------------------------------------------------------
PRP4_Mmus_PRP4 ------------------------------------------------------------
HIPK4_Mmus_HIPK ------------------------------------------------------------
HIPK3_Mmus_HIPK ------------------------------------------------------------
HIPK2_Mmus_HIPK ------------------------------------------------------------
HIPK1_Mmus_HIPK ------------------------------------------------------------
DYRK4_Mmus_DYRK2 ------------------------------------------------------------
DYRK3_Mmus_DYRK2 ------------------------------------------------------------
DYRK2_Mmus_DYRK2 ------------------------------------------------------------
DYRK1B_Mmus_DYRK1 ------------------------------------------------------------
DYRK1A_Mmus_DYRK1 ------------------------------------------------------------
mbk-2_Cele_DYRK2 ------------------------------------------------------------
mbk-1_Cele_DYRK1 ------------------------------------------------------------
hpk-1_Cele_HIPK ------------------------------------------------------------
F22D6.5_Cele_PRP4 ------------------------------------------------------------
C36B7.2_Cele_DYRK2 ------------------------------------------------------------
C36B7.1_Cele_DYRK2 ------------------------------------------------------------
DYRK4_Hsap_DYRK2 ------------------------------------------------------------
DYRK3_Hsap_DYRK2 ------------------------------------------------------------
DYRK2_Hsap_DYRK2 ------------------------------------------------------------
DYRK1B_Hsap_DYRK1 ------------------------------------------------------------
DYRK1A_Hsap_DYRK1 ------------------------------------------------------------
YAK1_Scer_YAK ------------------------------------------------------------
Dyrk1_Ddis_DYRK1 ------------------------------------------------------------
Dyrk2_Ddis_DYRK2 ------------------------------------------------------------
Prp4_Ddis_PRP4 ------------------------------------------------------------
YakA_Ddis_YAK ------------------------------------------------------------
22349_Tthe_YAK ------------------------------------------------------------
10580_Tthe_DyrkP ------------------------------------------------------------
22423_Tthe_DyrkP ------------------------------------------------------------
5306_Tthe_DYRK2 ------------------------------------------------------------
5356_Tthe_DYRK2 ------------------------------------------------------------
5655_Tthe_DYRK2 ------------------------------------------------------------
15575_Tthe_PRP4 KDKDRDNAKEKDRKRSKSPTKDKDRKNDRKRSKSPRSSNNGKRKSSRSKSPKREDSRRDK
DYRK1_Spur_DYRK1 ------------------------------------------------------------
DYRK2_Spur_DYRK2 ------------------------------------------------------------
DYRK4_Spur_DYRK2 ------------------------------------------------------------
HIPKa_Spur_HIPK ------------------------------------------------------------
HIPKb_Spur_HIPK ------------------------------------------------------------
PRP4_Spur_PRP4 ------------------------------------------------------------
CG7028_Dmel_PRP4 ------------------------------------------------------------
CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------
CC1G_04865_Ccin_PRP4 ------------------------------------------------------------
CC1G_14245_Ccin_YAK ------------------------------------------------------------
AqueK110_Aque_DYRK1 ------------------------------------------------------------
AqueK111_Aque_DYRK1 ------------------------------------------------------------
AqueK112_Aque_DYRK2 ------------------------------------------------------------
AqueK113_Aque_DYRK2 ------------------------------------------------------------
AqueK114_Aque_HIPK ------------------------------------------------------------
AqueK115_Aque_PRP4 ------------------------------------------------------------
AqueK116_Aque_PRP4 ------------------------------------------------------------
DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------
DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------
DYRKP-2_Smoe_DYRKP ------------------------------------------------------------
DYRKP-1_Smoe_DYRKP SHGIVEDPSASFANAGDGSAAEYPDEYWDSDAYEDDDDPGYTRRPIDDEKEFLASEINYP
PRP4_e_Smoe_PRP4 ------------------------------------------------------------
PRP4_d_Smoe_PRP4 ------------------------------------------------------------
PRP4_b_Smoe_PRP4 ------------------------------------------------------------
PRP4_a_Smoe_PRP4 ------------------------------------------------------------
PRP4_c_Smoe_PRP4 ------------------------------------------------------------
YAK_b_Smoe_YAK ------------------------------------------------------------
YAK_a_Smoe_YAK ------------------------------------------------------------
YAK_d_Smoe_YAK ------------------------------------------------------------
GK031_Glam_DYRK1 ------------------------------------------------------------
GK034_Glam_DYRK2 ------------------------------------------------------------
GK033_Glam_DYRK2 ------------------------------------------------------------
GK032_Glam_DYRK2 ------------------------------------------------------------
PRP4_Hsap_PRP4 ------------------------------------------------------------
HIPK4_Hsap_HIPK ------------------------------------------------------------
HIPK3_Hsap_HIPK ------------------------------------------------------------
HIPK2_Hsap_HIPK ------------------------------------------------------------
HIPK1_Hsap_HIPK ------------------------------------------------------------
smi35A_Dmel_DYRK2 ------------------------------------------------------------
mnb_Dmel_DYRK1 ------------------------------------------------------------
Dyrk3_Dmel_DYRK2 ------------------------------------------------------------
CG17090_Dmel_HIPK ------------------------------------------------------------
PRP4_Mmus_PRP4 ------------------------------------------------------------
HIPK4_Mmus_HIPK ------------------------------------------------------------
HIPK3_Mmus_HIPK ------------------------------------------------------------
HIPK2_Mmus_HIPK ------------------------------------------------------------
HIPK1_Mmus_HIPK ------------------------------------------------------------
DYRK4_Mmus_DYRK2 ------------------------------------------------------------
DYRK3_Mmus_DYRK2 ------------------------------------------------------------
DYRK2_Mmus_DYRK2 ------------------------------------------------------------
DYRK1B_Mmus_DYRK1 ------------------------------------------------------------
DYRK1A_Mmus_DYRK1 ------------------------------------------------------------
mbk-2_Cele_DYRK2 ------------------------------------------------------------
mbk-1_Cele_DYRK1 ------------------------------------------------------------
hpk-1_Cele_HIPK ------------------------------------------------------------
F22D6.5_Cele_PRP4 ------------------------------------------------------------
C36B7.2_Cele_DYRK2 ------------------------------------------------------------
C36B7.1_Cele_DYRK2 ------------------------------------------------------------
DYRK4_Hsap_DYRK2 ------------------------------------------------------------
DYRK3_Hsap_DYRK2 ------------------------------------------------------------
DYRK2_Hsap_DYRK2 ------------------------------------------------------------
DYRK1B_Hsap_DYRK1 ------------------------------------------------------------
DYRK1A_Hsap_DYRK1 ------------------------------------------------------------
YAK1_Scer_YAK ------------------------------------------------------------
Dyrk1_Ddis_DYRK1 ------------------------------------------------------------
Dyrk2_Ddis_DYRK2 ------------------------------------------------------------
Prp4_Ddis_PRP4 ------------------------------------------------------------
YakA_Ddis_YAK ------------------------------------------------------------
22349_Tthe_YAK ------------------------------------------------------------
10580_Tthe_DyrkP ------------------------------------------------------------
22423_Tthe_DyrkP ------------------------------------------------------------
5306_Tthe_DYRK2 ------------------------------------------------------------
5356_Tthe_DYRK2 ------------------------------------------------------------
5655_Tthe_DYRK2 ------------------------------------------------------------
15575_Tthe_PRP4 DSKSGYRDNEKKSNYGSNRDRESRRSEENNTRESKQLTLEEEEERNDRYYNDFDDSDSDY
DYRK1_Spur_DYRK1 ------------------------------------------------------------
DYRK2_Spur_DYRK2 ------------------------------------------------------------
DYRK4_Spur_DYRK2 ------------------------------------------------------------
HIPKa_Spur_HIPK ------------------------------------------------------------
HIPKb_Spur_HIPK ------------------------------------------------------------
PRP4_Spur_PRP4 ------------------------------------------------------------
CG7028_Dmel_PRP4 ------------------------------------------------------------
CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------
CC1G_04865_Ccin_PRP4 ------------------------------------------------------------
CC1G_14245_Ccin_YAK ------------------------------------------------------------
AqueK110_Aque_DYRK1 ------------------------------------------------------------
AqueK111_Aque_DYRK1 ------------------------------------------------------------
AqueK112_Aque_DYRK2 ------------------------------------------------------------
AqueK113_Aque_DYRK2 ------------------------------------------------------------
AqueK114_Aque_HIPK ------------------------------------------------------------
AqueK115_Aque_PRP4 ------------------------------------------------------------
AqueK116_Aque_PRP4 ------------------------------------------------------------
DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------
DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------
DYRKP-2_Smoe_DYRKP ------------------------------------------------------------
DYRKP-1_Smoe_DYRKP SEEERARIEHNPAQQGTTYGKYDDDDRSYVESYFSGEEYYRGRDARDNNGDADVDALCGA
PRP4_e_Smoe_PRP4 ------------------------------------------------------------
PRP4_d_Smoe_PRP4 ------------------------------------------------------------
PRP4_b_Smoe_PRP4 ------------------------------------------------------------
PRP4_a_Smoe_PRP4 ------------------------------------------------------------
PRP4_c_Smoe_PRP4 ------------------------------------------------------------
YAK_b_Smoe_YAK ------------------------------------------------------------
YAK_a_Smoe_YAK ------------------------------------------------------------
YAK_d_Smoe_YAK ------------------------------------------------------------
GK031_Glam_DYRK1 ------------------------------------------------------------
GK034_Glam_DYRK2 ------------------------------------------------------------
GK033_Glam_DYRK2 ------------------------------------------------------------
GK032_Glam_DYRK2 ------------------------------------------------------------
PRP4_Hsap_PRP4 ------------------------------------------------------------
HIPK4_Hsap_HIPK ------------------------------------------------------------
HIPK3_Hsap_HIPK ------------------------------------------------------------
HIPK2_Hsap_HIPK ------------------------------------------------------------
HIPK1_Hsap_HIPK ------------------------------------------------------------
smi35A_Dmel_DYRK2 ------------------------------------------------------------
mnb_Dmel_DYRK1 ------------------------------------------------------------
Dyrk3_Dmel_DYRK2 ------------------------------------------------------------
CG17090_Dmel_HIPK ------------------------------------------------------------
PRP4_Mmus_PRP4 ------------------------------------------------------------
HIPK4_Mmus_HIPK ------------------------------------------------------------
HIPK3_Mmus_HIPK ------------------------------------------------------------
HIPK2_Mmus_HIPK ------------------------------------------------------------
HIPK1_Mmus_HIPK ------------------------------------------------------------
DYRK4_Mmus_DYRK2 ------------------------------------------------------------
DYRK3_Mmus_DYRK2 ------------------------------------------------------------
DYRK2_Mmus_DYRK2 ------------------------------------------------------------
DYRK1B_Mmus_DYRK1 ------------------------------------------------------------
DYRK1A_Mmus_DYRK1 ------------------------------------------------------------
mbk-2_Cele_DYRK2 ------------------------------------------------------------
mbk-1_Cele_DYRK1 ------------------------------------------------------------
hpk-1_Cele_HIPK ------------------------------------------------------------
F22D6.5_Cele_PRP4 ------------------------------------------------------------
C36B7.2_Cele_DYRK2 ------------------------------------------------------------
C36B7.1_Cele_DYRK2 ------------------------------------------------------------
DYRK4_Hsap_DYRK2 ------------------------------------------------------------
DYRK3_Hsap_DYRK2 ------------------------------------------------------------
DYRK2_Hsap_DYRK2 ------------------------------------------------------------
DYRK1B_Hsap_DYRK1 ------------------------------------------------------------
DYRK1A_Hsap_DYRK1 ------------------------------------------------------------
YAK1_Scer_YAK ------------------------------------------------------------
Dyrk1_Ddis_DYRK1 ------------------------------------------------------------
Dyrk2_Ddis_DYRK2 ------------------------------------------------------------
Prp4_Ddis_PRP4 ------------------------------------------------------------
YakA_Ddis_YAK ------------------------------------------------------------
22349_Tthe_YAK ------------------------------------------------------------
10580_Tthe_DyrkP ------------------------------------------------------------
22423_Tthe_DyrkP ------------------------------------------------------------
5306_Tthe_DYRK2 ------------------------------------------------------------
5356_Tthe_DYRK2 ------------------------------------------------------------
5655_Tthe_DYRK2 ------------------------------------------------------------
15575_Tthe_PRP4 YQRVNDRKYKSSRRSKSRSKNRDRKKSKSKGRKDDKNKDKDKERSKNSGNGDNSKSSKDK
DYRK1_Spur_DYRK1 ------------------------------------------------------------
DYRK2_Spur_DYRK2 ------------------------------------------------------------
DYRK4_Spur_DYRK2 ------------------------------------------------------------
HIPKa_Spur_HIPK ------------------------------------------------------------
HIPKb_Spur_HIPK ------------------------------------------------------------
PRP4_Spur_PRP4 ------------------------------------------------------------
CG7028_Dmel_PRP4 ------------------------------------------------------------
CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------
CC1G_04865_Ccin_PRP4 ------------------------------------------------------------
CC1G_14245_Ccin_YAK ------------------------------------------------------------
AqueK110_Aque_DYRK1 ------------------------------------------------------------
AqueK111_Aque_DYRK1 ------------------------------------------------------------
AqueK112_Aque_DYRK2 ------------------------------------------------------------
AqueK113_Aque_DYRK2 ------------------------------------------------------------
AqueK114_Aque_HIPK ------------------------------------------------------------
AqueK115_Aque_PRP4 ------------------------------------------------------------
AqueK116_Aque_PRP4 ------------------------------------------------------------
DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------
DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------
DYRKP-2_Smoe_DYRKP ------------------------------------------------------------
DYRKP-1_Smoe_DYRKP ADELSFRPHANDYDGQLLDSEELKQIRSEPAWQGFVVQGNAIRKDQAATTANDQDDFSRE
PRP4_e_Smoe_PRP4 ------------------------------------------------------------
PRP4_d_Smoe_PRP4 ------------------------------------------------------------
PRP4_b_Smoe_PRP4 ------------------------------------------------------------
PRP4_a_Smoe_PRP4 ------------------------------------------------------------
PRP4_c_Smoe_PRP4 ------------------------------------------------------------
YAK_b_Smoe_YAK ------------------------------------------------------------
YAK_a_Smoe_YAK ------------------------------------------------------------
YAK_d_Smoe_YAK ------------------------------------------------------------
GK031_Glam_DYRK1 ------------------------------------------------------------
GK034_Glam_DYRK2 ------------------------------------------------------------
GK033_Glam_DYRK2 ------------------------------------------------------------
GK032_Glam_DYRK2 ------------------------------------------------------------
PRP4_Hsap_PRP4 ------------------------------------------------------------
HIPK4_Hsap_HIPK ------------------------------------------------------------
HIPK3_Hsap_HIPK ------------------------------------------------------------
HIPK2_Hsap_HIPK ------------------------------------------------------------
HIPK1_Hsap_HIPK ------------------------------------------------------------
smi35A_Dmel_DYRK2 ------------------------------------------------------------
mnb_Dmel_DYRK1 ------------------------------------------------------------
Dyrk3_Dmel_DYRK2 ------------------------------------------------------------
CG17090_Dmel_HIPK ------------------------------------------------------------
PRP4_Mmus_PRP4 ------------------------------------------------------------
HIPK4_Mmus_HIPK ------------------------------------------------------------
HIPK3_Mmus_HIPK ------------------------------------------------------------
HIPK2_Mmus_HIPK ------------------------------------------------------------
HIPK1_Mmus_HIPK ------------------------------------------------------------
DYRK4_Mmus_DYRK2 ------------------------------------------------------------
DYRK3_Mmus_DYRK2 ------------------------------------------------------------
DYRK2_Mmus_DYRK2 ------------------------------------------------------------
DYRK1B_Mmus_DYRK1 ------------------------------------------------------------
DYRK1A_Mmus_DYRK1 ------------------------------------------------------------
mbk-2_Cele_DYRK2 ------------------------------------------------------------
mbk-1_Cele_DYRK1 ------------------------------------------------------------
hpk-1_Cele_HIPK ------------------------------------------------------------
F22D6.5_Cele_PRP4 ------------------------------------------------------------
C36B7.2_Cele_DYRK2 ------------------------------------------------------------
C36B7.1_Cele_DYRK2 ------------------------------------------------------------
DYRK4_Hsap_DYRK2 ------------------------------------------------------------
DYRK3_Hsap_DYRK2 ------------------------------------------------------------
DYRK2_Hsap_DYRK2 ------------------------------------------------------------
DYRK1B_Hsap_DYRK1 ------------------------------------------------------------
DYRK1A_Hsap_DYRK1 ------------------------------------------------------------
YAK1_Scer_YAK ------------------------------------------------------------
Dyrk1_Ddis_DYRK1 ------------------------------------------------------------
Dyrk2_Ddis_DYRK2 ------------------------------------------------------------
Prp4_Ddis_PRP4 ------------------------------------------------------------
YakA_Ddis_YAK ------------------------------------------------------------
22349_Tthe_YAK ------------------------------------------------------------
10580_Tthe_DyrkP ------------------------------------------------------------
22423_Tthe_DyrkP ------------------------------------------------------------
5306_Tthe_DYRK2 ------------------------------------------------------------
5356_Tthe_DYRK2 ------------------------------------------------------------
5655_Tthe_DYRK2 ------------------------------------------------------------
15575_Tthe_PRP4 KEEEAKKAQQPETIDDDEDLNMEIEDSDDERERKKQEFLNMIKVQGMQMQKQEASQTFSK
DYRK1_Spur_DYRK1 ------------------------------------------------------------
DYRK2_Spur_DYRK2 ------------------------------------------------------------
DYRK4_Spur_DYRK2 ------------------------------------------------------------
HIPKa_Spur_HIPK ------------------------------------------------------------
HIPKb_Spur_HIPK ------------------------------------------------------------
PRP4_Spur_PRP4 ------------------------------------------------------------
CG7028_Dmel_PRP4 ------------------------------------------------------------
CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------
CC1G_04865_Ccin_PRP4 ------------------------------------------------------------
CC1G_14245_Ccin_YAK ------------------------------------------------------------
AqueK110_Aque_DYRK1 ------------------------------------------------------------
AqueK111_Aque_DYRK1 ------------------------------------------------------------
AqueK112_Aque_DYRK2 ------------------------------------------------------------
AqueK113_Aque_DYRK2 ------------------------------------------------------------
AqueK114_Aque_HIPK ------------------------------------------------------------
AqueK115_Aque_PRP4 ------------------------------------------------------------
AqueK116_Aque_PRP4 ------------------------------------------------------------
DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------
DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------
DYRKP-2_Smoe_DYRKP ------------------------------------------------------------
DYRKP-1_Smoe_DYRKP IRETYLAESSDGEVGSLQDCDFQGRNGFLDVEKRRQQCFKQGGPSSAEEEHDIVLQYYNR
PRP4_e_Smoe_PRP4 ------------------------------------------------------------
PRP4_d_Smoe_PRP4 ------------------------------------------------------------
PRP4_b_Smoe_PRP4 ------------------------------------------------------------
PRP4_a_Smoe_PRP4 ------------------------------------------------------------
PRP4_c_Smoe_PRP4 ------------------------------------------------------------
YAK_b_Smoe_YAK ------------------------------------------------------------
YAK_a_Smoe_YAK ------------------------------------------------------------
YAK_d_Smoe_YAK ------------------------------------------------------------
GK031_Glam_DYRK1 ------------------------------------------------------------
GK034_Glam_DYRK2 ------------------------------------------------------------
GK033_Glam_DYRK2 ------------------------------------------------------------
GK032_Glam_DYRK2 ------------------------------------------------------------
PRP4_Hsap_PRP4 ------------------------------------------------------------
HIPK4_Hsap_HIPK ------------------------------------------------------------
HIPK3_Hsap_HIPK ------------------------------------------------------------
HIPK2_Hsap_HIPK ------------------------------------------------------------
HIPK1_Hsap_HIPK ------------------------------------------------------------
smi35A_Dmel_DYRK2 ------------------------------------------------------------
mnb_Dmel_DYRK1 ------------------------------------------------------------
Dyrk3_Dmel_DYRK2 ------------------------------------------------------------
CG17090_Dmel_HIPK ------------------------------------------------------------
PRP4_Mmus_PRP4 ------------------------------------------------------------
HIPK4_Mmus_HIPK ------------------------------------------------------------
HIPK3_Mmus_HIPK ------------------------------------------------------------
HIPK2_Mmus_HIPK ------------------------------------------------------------
HIPK1_Mmus_HIPK ------------------------------------------------------------
DYRK4_Mmus_DYRK2 ------------------------------------------------------------
DYRK3_Mmus_DYRK2 ------------------------------------------------------------
DYRK2_Mmus_DYRK2 ------------------------------------------------------------
DYRK1B_Mmus_DYRK1 ------------------------------------------------------------
DYRK1A_Mmus_DYRK1 ------------------------------------------------------------
mbk-2_Cele_DYRK2 ------------------------------------------------------------
mbk-1_Cele_DYRK1 ------------------------------------------------------------
hpk-1_Cele_HIPK ------------------------------------------------------------
F22D6.5_Cele_PRP4 ------------------------------------------------------------
C36B7.2_Cele_DYRK2 ------------------------------------------------------------
C36B7.1_Cele_DYRK2 ------------------------------------------------------------
DYRK4_Hsap_DYRK2 ------------------------------------------------------------
DYRK3_Hsap_DYRK2 ------------------------------------------------------------
DYRK2_Hsap_DYRK2 ------------------------------------------------------------
DYRK1B_Hsap_DYRK1 ------------------------------------------------------------
DYRK1A_Hsap_DYRK1 ------------------------------------------------------------
YAK1_Scer_YAK ------------------------------------------------------------
Dyrk1_Ddis_DYRK1 ------------------------------------------------------------
Dyrk2_Ddis_DYRK2 ------------------------------------------------------------
Prp4_Ddis_PRP4 ------------------------------------------------------------
YakA_Ddis_YAK ------------------------------------------------------------
22349_Tthe_YAK ------------------------------------------------------------
10580_Tthe_DyrkP ------------------------------------------------------------
22423_Tthe_DyrkP ------------------------------------------------------------
5306_Tthe_DYRK2 ------------------------------------------------------------
5356_Tthe_DYRK2 ------------------------------------------------------------
5655_Tthe_DYRK2 ------------------------------------------------------------
15575_Tthe_PRP4 ENNQNNQTQNKNDQDVVDDKLKVKDSENLENQNFADENSEEQLFDDTGLNPNDVLDDDDV
DYRK1_Spur_DYRK1 ------------------------------------------------------------
DYRK2_Spur_DYRK2 ------------------------------------------------------------
DYRK4_Spur_DYRK2 ------------------------------------------------------------
HIPKa_Spur_HIPK ------------------------------------------------------------
HIPKb_Spur_HIPK ------------------------------------------------------------
PRP4_Spur_PRP4 ------------------------------------------------------------
CG7028_Dmel_PRP4 ------------------------------------------------------------
CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------
CC1G_04865_Ccin_PRP4 ------------------------------------------------------------
CC1G_14245_Ccin_YAK ------------------------------------------------------------
AqueK110_Aque_DYRK1 ------------------------------------------------------------
AqueK111_Aque_DYRK1 ------------------------------------------------------------
AqueK112_Aque_DYRK2 ------------------------------------------------------------
AqueK113_Aque_DYRK2 ------------------------------------------------------------
AqueK114_Aque_HIPK ------------------------------------------------------------
AqueK115_Aque_PRP4 ------------------------------------------------------------
AqueK116_Aque_PRP4 ------------------------------------------------------------
DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------
DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------
DYRKP-2_Smoe_DYRKP ------------------------------------------------------------
DYRKP-1_Smoe_DYRKP PWGHKAQANGCEEVDRNGSVETQLAEEQLGAFQFGGFSFPSPSSAGDVDGSRAESGRSLW
PRP4_e_Smoe_PRP4 ------------------------------------------------------------
PRP4_d_Smoe_PRP4 ------------------------------------------------------------
PRP4_b_Smoe_PRP4 ------------------------------------------------------------
PRP4_a_Smoe_PRP4 ------------------------------------------------------------
PRP4_c_Smoe_PRP4 ------------------------------------------------------------
YAK_b_Smoe_YAK ------------------------------------------------------------
YAK_a_Smoe_YAK ------------------------------------------------------------
YAK_d_Smoe_YAK ------------------------------------------------------------
GK031_Glam_DYRK1 ------------------------------------------------------------
GK034_Glam_DYRK2 ------------------------------------------------------------
GK033_Glam_DYRK2 ------------------------------------------------------------
GK032_Glam_DYRK2 ------------------------------------------------------------
PRP4_Hsap_PRP4 ------------------------------------------------------------
HIPK4_Hsap_HIPK ------------------------------------------------------------
HIPK3_Hsap_HIPK ------------------------------------------------------------
HIPK2_Hsap_HIPK ------------------------------------------------------------
HIPK1_Hsap_HIPK ------------------------------------------------------------
smi35A_Dmel_DYRK2 ------------------------------------------------------------
mnb_Dmel_DYRK1 ------------------------------------------------------------
Dyrk3_Dmel_DYRK2 ------------------------------------------------------------
CG17090_Dmel_HIPK ------------------------------------------------------------
PRP4_Mmus_PRP4 ------------------------------------------------------------
HIPK4_Mmus_HIPK ------------------------------------------------------------
HIPK3_Mmus_HIPK ------------------------------------------------------------
HIPK2_Mmus_HIPK ------------------------------------------------------------
HIPK1_Mmus_HIPK ------------------------------------------------------------
DYRK4_Mmus_DYRK2 ------------------------------------------------------------
DYRK3_Mmus_DYRK2 ------------------------------------------------------------
DYRK2_Mmus_DYRK2 ------------------------------------------------------------
DYRK1B_Mmus_DYRK1 ------------------------------------------------------------
DYRK1A_Mmus_DYRK1 ------------------------------------------------------------
mbk-2_Cele_DYRK2 ------------------------------------------------------------
mbk-1_Cele_DYRK1 ------------------------------------------------------------
hpk-1_Cele_HIPK ------------------------------------------------------------
F22D6.5_Cele_PRP4 ------------------------------------------------------------
C36B7.2_Cele_DYRK2 ------------------------------------------------------------
C36B7.1_Cele_DYRK2 ------------------------------------------------------------
DYRK4_Hsap_DYRK2 ------------------------------------------------------------
DYRK3_Hsap_DYRK2 ------------------------------------------------------------
DYRK2_Hsap_DYRK2 ------------------------------------------------------------
DYRK1B_Hsap_DYRK1 ------------------------------------------------------------
DYRK1A_Hsap_DYRK1 ------------------------------------------------------------
YAK1_Scer_YAK ------------------------------------------------------------
Dyrk1_Ddis_DYRK1 ------------------------------------------------------------
Dyrk2_Ddis_DYRK2 ------------------------------------------------------------
Prp4_Ddis_PRP4 ------------------------------------------------------------
YakA_Ddis_YAK ------------------------------------------------------------
22349_Tthe_YAK ------------------------------------------------------------
10580_Tthe_DyrkP ------------------------------------------------------------
22423_Tthe_DyrkP ------------------------------------------------------------
5306_Tthe_DYRK2 ------------------------------------------------------------
5356_Tthe_DYRK2 ------------------------------------------------------------
5655_Tthe_DYRK2 ------------------------------------------------------------
15575_Tthe_PRP4 NIANTINDDYKEEVDESHSLTHRHSIDKAQLDHLKFLEDMRNQEIKGGIPDMPEQPILKQ
DYRK1_Spur_DYRK1 ------------------------------------------------------------
DYRK2_Spur_DYRK2 ------------------------------------------------------------
DYRK4_Spur_DYRK2 ------------------------------------------------------------
HIPKa_Spur_HIPK ------------------------------------------------------------
HIPKb_Spur_HIPK ------------------------------------------------------------
PRP4_Spur_PRP4 ------------------------------------------------------------
CG7028_Dmel_PRP4 ------------------------------------------------------------
CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------
CC1G_04865_Ccin_PRP4 ------------------------------------------------------------
CC1G_14245_Ccin_YAK ------------------------------------------------------------
AqueK110_Aque_DYRK1 ------------------------------------------------------------
AqueK111_Aque_DYRK1 ------------------------------------------------------------
AqueK112_Aque_DYRK2 ------------------------------------------------------------
AqueK113_Aque_DYRK2 ------------------------------------------------------------
AqueK114_Aque_HIPK ------------------------------------------------------------
AqueK115_Aque_PRP4 ------------------------------------------------------------
AqueK116_Aque_PRP4 ------------------------------------------------------------
DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------
DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------
DYRKP-2_Smoe_DYRKP ------------------------------------------------------------
DYRKP-1_Smoe_DYRKP STREISSRGEEVDQFANGFVGPDDTLASWKRKSNESSPIISGGEDHELRLALSTHSTVSP
PRP4_e_Smoe_PRP4 ------------------------------------------------------------
PRP4_d_Smoe_PRP4 ------------------------------------------------------------
PRP4_b_Smoe_PRP4 ------------------------------------------------------------
PRP4_a_Smoe_PRP4 ------------------------------------------------------------
PRP4_c_Smoe_PRP4 ------------------------------------------------------------
YAK_b_Smoe_YAK ------------------------------------------------------------
YAK_a_Smoe_YAK ------------------------------------------------------------
YAK_d_Smoe_YAK ------------------------------------------------------------
GK031_Glam_DYRK1 ------------------------------------------------------------
GK034_Glam_DYRK2 ------------------------------------------------------------
GK033_Glam_DYRK2 ------------------------------------------------------------
GK032_Glam_DYRK2 ------------------------------------------------------------
PRP4_Hsap_PRP4 ------------------------------------------------------------
HIPK4_Hsap_HIPK ------------------------------------------------------------
HIPK3_Hsap_HIPK ------------------------------------------------------------
HIPK2_Hsap_HIPK ------------------------------------------------------------
HIPK1_Hsap_HIPK ------------------------------------------------------------
smi35A_Dmel_DYRK2 ------------------------------------------------------------
mnb_Dmel_DYRK1 ------------------------------------------------------------
Dyrk3_Dmel_DYRK2 ------------------------------------------------------------
CG17090_Dmel_HIPK ------------------------------------------------------------
PRP4_Mmus_PRP4 ------------------------------------------------------------
HIPK4_Mmus_HIPK ------------------------------------------------------------
HIPK3_Mmus_HIPK ------------------------------------------------------------
HIPK2_Mmus_HIPK ------------------------------------------------------------
HIPK1_Mmus_HIPK ------------------------------------------------------------
DYRK4_Mmus_DYRK2 ------------------------------------------------------------
DYRK3_Mmus_DYRK2 ------------------------------------------------------------
DYRK2_Mmus_DYRK2 ------------------------------------------------------------
DYRK1B_Mmus_DYRK1 ------------------------------------------------------------
DYRK1A_Mmus_DYRK1 ------------------------------------------------------------
mbk-2_Cele_DYRK2 ------------------------------------------------------------
mbk-1_Cele_DYRK1 ------------------------------------------------------------
hpk-1_Cele_HIPK ------------------------------------------------------------
F22D6.5_Cele_PRP4 ------------------------------------------------------------
C36B7.2_Cele_DYRK2 ------------------------------------------------------------
C36B7.1_Cele_DYRK2 ------------------------------------------------------------
DYRK4_Hsap_DYRK2 ------------------------------------------------------------
DYRK3_Hsap_DYRK2 ------------------------------------------------------------
DYRK2_Hsap_DYRK2 ------------------------------------------------------------
DYRK1B_Hsap_DYRK1 ------------------------------------------------------------
DYRK1A_Hsap_DYRK1 ------------------------------------------------------------
YAK1_Scer_YAK ------------------------------------------------------------
Dyrk1_Ddis_DYRK1 ------------------------------------------------------------
Dyrk2_Ddis_DYRK2 ------------------------------------------------------------
Prp4_Ddis_PRP4 ------------------------------------------------------------
YakA_Ddis_YAK ------------------------------------------------------------
22349_Tthe_YAK ------------------------------------------------------------
10580_Tthe_DyrkP ------------------------------------------------------------
22423_Tthe_DyrkP ------------------------------------------------------------
5306_Tthe_DYRK2 ------------------------------------------------------------
5356_Tthe_DYRK2 ------------------------------------------------------------
5655_Tthe_DYRK2 ------------------------------------------------------------
15575_Tthe_PRP4 KRKSINSEKLEGKFSNNDQLDEENKLHKLDDQEDSEEETDMFGDDIDKIINKSNDGKLQI
DYRK1_Spur_DYRK1 ------------------------------------------------------------
DYRK2_Spur_DYRK2 ------------------------------------------------------------
DYRK4_Spur_DYRK2 ------------------------------------------------------------
HIPKa_Spur_HIPK ------------------------------------------------------------
HIPKb_Spur_HIPK ------------------------------------------------------------
PRP4_Spur_PRP4 ------------------------------------------------------------
CG7028_Dmel_PRP4 ------------------------------------------------------------
CC1G_13957_Ccin_DYRK2 ------------------------------------------------------------
CC1G_04865_Ccin_PRP4 ------------------------------------------------------------
CC1G_14245_Ccin_YAK ------------------------------------------------------------
AqueK110_Aque_DYRK1 ------------------------------------------------------------
AqueK111_Aque_DYRK1 ------------------------------------------------------------
AqueK112_Aque_DYRK2 ------------------------------------------------------------
AqueK113_Aque_DYRK2 ------------------------------------------------------------
AqueK114_Aque_HIPK ------------------------------------------------------------
AqueK115_Aque_PRP4 ------------------------------------------------------------
AqueK116_Aque_PRP4 ------------------------------------------------------------
DYRK2_b_Smoe_DYRK2 ------------------------------------------------------------
DYRK2_a_Smoe_DYRK2 ------------------------------------------------------------
DYRKP-2_Smoe_DYRKP ------------------------------------------------------------
DYRKP-1_Smoe_DYRKP GSTEDSLSVEEERVDDEDVDAQRDETEAAAAYDEEAIAVHEHFHRLQAEEEEFETFDLKI
PRP4_e_Smoe_PRP4 ------------------------------------------------------------
PRP4_d_Smoe_PRP4 ------------------------------------------------------------
PRP4_b_Smoe_PRP4 ------------------------------------------------------------
PRP4_a_Smoe_PRP4 ------------------------------------------------------------
PRP4_c_Smoe_PRP4 ------------------------------------------------------------
YAK_b_Smoe_YAK ------------------------------------------------------------
YAK_a_Smoe_YAK ------------------------------------------------------------
YAK_d_Smoe_YAK ------------------------------------------------------------
GK031_Glam_DYRK1 ------------------------------------------------------------
GK034_Glam_DYRK2 ------------------------------------------------------------
GK033_Glam_DYRK2 ------------------------------------------------------------
GK032_Glam_DYRK2 ------------------------------------------------------------
PRP4_Hsap_PRP4 --------------------------YNVYGYTG-QGVFSNVVRARDNAR----------
HIPK4_Hsap_HIPK --------------------------YDIIEVLG-KGTFGEVAKGWRRS-----------
HIPK3_Hsap_HIPK --------------------------YEVLDFLG-RGTFGQVVKCWKRG-----------
HIPK2_Hsap_HIPK --------------------------YEVLEFLG-RGTFGQVVKCWKRG-----------
HIPK1_Hsap_HIPK --------------------------YEVLEFLG-RGTFGQVAKCWKRS-----------
smi35A_Dmel_DYRK2 --------------------------YEILEVIG-KGSFGQVIRALDHK-----------
mnb_Dmel_DYRK1 --------------------------YEIDSLIG-KGSFGQVVKAYDHE-----------
Dyrk3_Dmel_DYRK2 --------------------------YEMLKIIG-KGSFGQVIKAYDHK-----------
CG17090_Dmel_HIPK --------------------------YEVLEFLG-RGTFGQVVKCWKRG-----------
PRP4_Mmus_PRP4 --------------------------YNVYGYTG-QGVFSNVVRARDNAR----------
HIPK4_Mmus_HIPK --------------------------YDIIEVLG-KGTFGEVAKGWRRS-----------
HIPK3_Mmus_HIPK --------------------------YEVLDFLG-RGTFGQVVKCWKRG-----------
HIPK2_Mmus_HIPK --------------------------YEVLEFLG-RGTFGQVVKCWKRG-----------
HIPK1_Mmus_HIPK --------------------------YEVLEFLG-RGTFGQVAKCWKRS-----------
DYRK4_Mmus_DYRK2 --------------------------YEVLEMIG-KGSFGQVAKCLDHK-----------
DYRK3_Mmus_DYRK2 --------------------------YEVLKIIG-KGSFGQVARVYDHK-----------
DYRK2_Mmus_DYRK2 --------------------------YEVLKVIG-KGSFGQVVKAYDHK-----------
DYRK1B_Mmus_DYRK1 --------------------------YEIDSLIG-KGSFGQVVKAYDHQ-----------
DYRK1A_Mmus_DYRK1 --------------------------YEIDSLIG-KGSFGQVVKAYDRV-----------
mbk-2_Cele_DYRK2 --------------------------YEVLKVIG-KGSFGQVIKAFDHK-----------
mbk-1_Cele_DYRK1 --------------------------ILSDTPVG-KGSFGQVTKAYDTL-----------
hpk-1_Cele_HIPK --------------------------YEVLEFLG-KGTFGQVVKAWKKG-----------
F22D6.5_Cele_PRP4 --------------------------YRVVGFTG-AGVFGNVCRCNDQT-----------
C36B7.2_Cele_DYRK2 --------------------------YTIDKVIG-QGCYGVVGEATDGK-----------
C36B7.1_Cele_DYRK2 --------------------------YSIDEVLS-SGYYAQVFRCTDKK-----------
DYRK4_Hsap_DYRK2 --------------------------YEVLETIG-KGSFGQVAKCLDHK-----------
DYRK3_Hsap_DYRK2 --------------------------YEVLKIIG-KGSFGQVARVYDHK-----------
DYRK2_Hsap_DYRK2 --------------------------YEVLKVIG-KGSFGQVVKAYDHK-----------
DYRK1B_Hsap_DYRK1 --------------------------YEIDSLIG-KGSFGQVVKAYDHQ-----------
DYRK1A_Hsap_DYRK1 --------------------------YEIDSLIG-KGSFGQVVKAYDRV-----------
YAK1_Scer_YAK --------------------------YLVLDILG-QGTFGQVVKCQNLL-----------
Dyrk1_Ddis_DYRK1 --------------------------FEIISSLG-KGSFGQVVKAFDSV-----------
Dyrk2_Ddis_DYRK2 --------------------------FEIVSILG-QGSFCQVVKGYDYK-----------
Prp4_Ddis_PRP4 --------------------------YQIFSPIG-SGVFSTVVSAKETKT----------
YakA_Ddis_YAK --------------------------YKVLDSLG-QGTFGQVVKCKNCD-----------
22349_Tthe_YAK --------------------------YIIEDMLG-KGTFGQVAKCSKNG-----------
10580_Tthe_DyrkP --------------------------YQIMEYLG-SAAFSKAIQCQDKQ-----------
22423_Tthe_DyrkP --------------------------YQVMEYLG-SAAFSKAIQCLDLV-----------
5306_Tthe_DYRK2 --------------------------YEIKEFLG-KGSFGQVLKVFDHK-----------
5356_Tthe_DYRK2 --------------------------YELIEALG-KGSFGQVIKVFDHK-----------
5655_Tthe_DYRK2 --------------------------YELLECLG-KGSFGSVVKVFDHK-----------
15575_Tthe_PRP4 VKGANAECDDEQNYFKILIGEVLNGKYRVIQKCG-KGVFANVCKAEQLD-----------
DYRK1_Spur_DYRK1 --------------------------YEIDSLIG-KGSFGQVAKAYDHQ-----------
DYRK2_Spur_DYRK2 --------------------------YEVLKILG-KGSFGQVVKVYDHK-----------
DYRK4_Spur_DYRK2 --------------------------YEILEVIG-KGSFGQVVKAFDHK-----------
HIPKa_Spur_HIPK --------------------------YEVLEFLG-RGTFGQVVKCWKRG-----------
HIPKb_Spur_HIPK ------------------------------------------------------------
PRP4_Spur_PRP4 -------------------GESLDKRYAVYGYTG-QGVFSNVVRARDTAR----------
CG7028_Dmel_PRP4 --------------------------YLVNGYTG-QGVFSNVVRGRDQAR----------
CC1G_13957_Ccin_DYRK2 --------------------------YEVVDTLG-KGSFGQVLNCRDHC-----------
CC1G_04865_Ccin_PRP4 --------------------------YQVFSSLG-QGMFANVVRARVLKDENGKDLAVDG
CC1G_14245_Ccin_YAK --------------------------YLILDILG-QGTFGQVVKCQNMK-----------
AqueK110_Aque_DYRK1 --------------------------R---------------------------------
AqueK111_Aque_DYRK1 --------------------------YEIDSLIG-KGSFGQVVKAFDLE-----------
AqueK112_Aque_DYRK2 --------------------------YEIREIIG-KGSFGQVVKVFDHK-----------
AqueK113_Aque_DYRK2 --------------------------YEVLKVLG-KGSFGQVLKAYDHK-----------
AqueK114_Aque_HIPK --------------------------YDVLDRLG-RGTFGQVVRAWKKN-----------
AqueK115_Aque_PRP4 --------------------------YMVYGYTG-QGVFSNVVRARDTSR----------
AqueK116_Aque_PRP4 --------------------------YMVYGYTG-HGVFSNVVRARDTSR----------
DYRK2_b_Smoe_DYRK2 --------------------------YEILGKLG-RGSFGQVLKCTDHK-----------
DYRK2_a_Smoe_DYRK2 --------------------------YEILGKLG-RGSFGQVLKCTDHK-----------
DYRKP-2_Smoe_DYRKP ------------------------------------------------------------
DYRKP-1_Smoe_DYRKP IHRKNRTGFEEDKDFQVLINSVIAGRYHVTEFLG-AAAFSKAIQAHDLF-----------
PRP4_e_Smoe_PRP4 --------------------------YQVKASIG-SGMFSTVFLAKSLFP----------
PRP4_d_Smoe_PRP4 --------------------------YQVKASIG-SGMFSTVFLAKSLLP----------
PRP4_b_Smoe_PRP4 --------------------------YEIASSHG-RGVFSTVVRARDTKAGR--------
PRP4_a_Smoe_PRP4 -------------------GEVLDNRYEIASSHG-RGVFSTVVRARDTKAGR--------
PRP4_c_Smoe_PRP4 ------------------------------------------------------------
YAK_b_Smoe_YAK --------------------------YVVKEMLG-QGTFGQVVKCWSDR-----------
YAK_a_Smoe_YAK --------------------------YVVKEMLG-QGTFGQVVKCWSDR-----------
YAK_d_Smoe_YAK ------------------------------------------------------------
GK031_Glam_DYRK1 --------------------------YCAERPLG-QGSFGRVVLAKDTV-----------
GK034_Glam_DYRK2 --------------------------YELVSKLG-SGSFGKVYKALDHK-----------
GK033_Glam_DYRK2 --------------------------YKLLKMVG-SATFSNVFSCLDLK-----------
GK032_Glam_DYRK2 --------------------------YEIYKTIFEDSAFSVTLKARDLK-----------
PRP4_Hsap_PRP4 ----ANQEVAVKIIRNNELMQKTGLKELEFLKKLND-AD---P-DDKFHCLRLFRHFYHK
HIPK4_Hsap_HIPK ----TGEMVAIKILKNDAYRNRIIKNELKLLHCMRG-LDPE-----EAHVIRFLEFFHDA
HIPK3_Hsap_HIPK ----TNEIVAIKILKNHPSYARQGQIEVSILARLST-ENAD-----EYNFVRAYECFQHR
HIPK2_Hsap_HIPK ----TNEIVAIKILKNHPSYARQGQIEVSILARLST-ESAD-----DYNFVRAYECFQHK
HIPK1_Hsap_HIPK ----TKEIVAIKILKNHPSYARQGQIEVSILSRLSS-ENAD-----EYNFVRSYECFQHK
smi35A_Dmel_DYRK2 ----TNTHVAIKIIRNKKRFLNQAVVELNILDELRE-KDAD----GSHNVIHMLDYTYFR
mnb_Dmel_DYRK1 ----EQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNR-ADAE----NKYYIVKLKRHFMWR
Dyrk3_Dmel_DYRK2 ----THEHVALKIVRNEKRFHRQAQEEIRILHHLRR-HDKY----NTMNIIHMFDYFTFR
CG17090_Dmel_HIPK ----TSEIVAIKILKNHPSYARQGQIEVSILSRLSQ-ENAD-----EFNFVRAFECFQHK
PRP4_Mmus_PRP4 ----ANQEVAVKIIRNNELMQKTGLKELEFLKKLND-AD---P-DDKFHCLRLFRHFYHK
HIPK4_Mmus_HIPK ----TGEMVAIKILKNDAYRSRIIKNELKLLRCVRG-LDPD-----EAHVIRFLEFFHDA
HIPK3_Mmus_HIPK ----TNEIVAIKILKNHPSYARQGQIEVSILARLST-ENAD-----EYNFVRAYECFQHR
HIPK2_Mmus_HIPK ----TNEIVAIKILKNHPSYARQGQIEVSILARLST-ESAD-----DYNFVRAYECFQHK
HIPK1_Mmus_HIPK ----TKEIVAIKILKNHPSYARQGQIEVSILSRLSS-ENAD-----EYNFVRSYECFQHK
DYRK4_Mmus_DYRK2 ----NNELVALKIIRNKKRFHHQALVELKILEALRR-KDKD----NNHNVVHMKDFFYFR
DYRK3_Mmus_DYRK2 ----LRQYVALKMVRNEKRFHRQAAEEIRILEHLKK-QDKT----GSMNVIHMLESFTFR
DYRK2_Mmus_DYRK2 ----VHQHVALKMVRNEKRFHRQAAEEIRILEHLRK-QDKD----NTMNVIHMLENFTFR
DYRK1B_Mmus_DYRK1 ----TQELVAIKIIKNKKAFLNQAQIELRLLELMNQ-HDTE----MKYYIVHLKRHFMFR
DYRK1A_Mmus_DYRK1 ----EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNK-HDTE----MKYYIVHLKRHFMFR
mbk-2_Cele_DYRK2 ----YQQYVALKLVRNEKRFHRQADEEIRILDHLRR-QDSD----GTHNIIHMLDYFNFR
mbk-1_Cele_DYRK1 ----NKEEVAIKIIKNKKTFFDQAQIEIHLLELTNA-HDKD----NKYNIVTLKGHFVHR
hpk-1_Cele_HIPK ----TSEIVAIKILKKHPSYARQGQIEVSILSRLSN-ENSE-----EFNFVRAFECFNHK
F22D6.5_Cele_PRP4 ----KGNTVAVKIIRNNEVMYKTGLRELEVLRKLNE-AD---K-EDKYHCLRLFRTFKHH
C36B7.2_Cele_DYRK2 ----TKQKVAIRMVSKL---APRIYRETEMIMYISS-ID---P-DHTFDCVRMLDYNVFR
C36B7.1_Cele_DYRK2 ----TDKKVCIKLKNRN---LSTTYEETIILLRIHQ-LN---R-QNNSNCVRMLDYDHFR
DYRK4_Hsap_DYRK2 ----NNELVALKIIRNKKRFHQQALMELKILEALRK-KDKD----NTYNVVHMKDFFYFR
DYRK3_Hsap_DYRK2 ----LRQYVALKMVRNEKRFHRQAAEEIRILEHLKK-QDKT----GSMNVIHMLESFTFR
DYRK2_Hsap_DYRK2 ----VHQHVALKMVRNEKRFHRQAAEEIRILEHLRK-QDKD----NTMNVIHMLENFTFR
DYRK1B_Hsap_DYRK1 ----TQELVAIKIIKNKKAFLNQAQIELRLLELMNQ-HDTE----MKYYIVHLKRHFMFR
DYRK1A_Hsap_DYRK1 ----EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNK-HDTE----MKYYIVHLKRHFMFR
YAK1_Scer_YAK ----TKEILAVKVVKSRTEYLTQSITEAKILELLNQKID---P-TNKHHFLRMYDSFVHK
Dyrk1_Ddis_DYRK1 ----LKEYVAIKIIKNKVPFYNQALIEIRLLELMNN-KDPE----DQYKIIKLKHHFKFR
Dyrk2_Ddis_DYRK2 ----TGEMVALKILRNQKRFHNQALTEIKILEYLKT-NDPN----STASIVHLNNYFYFR
Prp4_Ddis_PRP4 -----NEDVVIKIIRNRPSMHRSGLKEIEILQKISN-TPTS-S-NQKSHCIQMKDHFNYR
YakA_Ddis_YAK ----TDELVAIKILKNKQAYFQQGRLEIQTLKSLNDQHD---P-EDKNHILRLLDSFIHK
22349_Tthe_YAK ----TNDLFAVKVIKNRPAYFQQAKNEILLLRVLNK-QEEQNGENYQKRIVNLVDFFVFR
10580_Tthe_DyrkP ----TGQMLCMKIIENNKDYFDQSIDEIKLLKYINY-NG---D-VDEKNVLKVYDYFYHK
22423_Tthe_DyrkP ----TNRVMCMKIIENNKDYFDQSIDEIKLLRYINY-NG---D-VDEKNVLRYFDYFYHK
5306_Tthe_DYRK2 ----RKEYAALKVIRNKQKFHEQALIELNILHYIKE-KDYD----NQTNIVKIRDFVIFR
5356_Tthe_DYRK2 ----RKEYSALKIIRNKKNFYNQAIVELNILKYIKD-NDPQ----NQTNIVKIKDFVIFR
5655_Tthe_DYRK2 ----RKEFLALKVIRNKKKFHNQALIELNILSYIKE-QDKD----EATNIVRIKDFVIFR
15575_Tthe_PRP4 ----NGKMVAIKILRSNEIMRDSGEREKEIIQKLNL-ND---K-NDRKHIVRLKNVFEHQ
DYRK1_Spur_DYRK1 ----EQEYVAIKIIKNKKPFLNQAQIEVRLLELMNK-HDAD----SKYYIVKLKRHFMFR
DYRK2_Spur_DYRK2 ----TNQHIAVKMVRNEKRFHRQAQEEIRILEHLRK-QDKD----NNMNLIHMFESFSFR
DYRK4_Spur_DYRK2 ----LGEMIAIKIIRNKKRFHHQALIEVKILDALRR-KDRD----NSHNVVHMREYFYYR
HIPKa_Spur_HIPK ----TNEIVAIKILKNHPSYARQGQIEVSILARLSA-ENAD-----DFNLVRAYEYFQHK
HIPKb_Spur_HIPK ------------------------------------------------------------
PRP4_Spur_PRP4 ----GKLDVAIKIIRNNDLMQKTGMKELEYLKRLND-QD---R-EDKFHCVRLFRSFSYR
CG7028_Dmel_PRP4 ----GQANVAIKIIRNNEIMHKTGLRELEILKKLND-AD---P-EDRFHCLRLYRHFFHK
CC1G_13957_Ccin_DYRK2 ----TGESVAVKIIRNKKRFHHQALVEIKILDNLRK-WDAD----EKHHVLKMTEHFYFR
CC1G_04865_Ccin_PRP4 VAPESLREVAIKIIRSQESMYKAGLKEAQILQKLRA-LD---P-EDKKHIVKLERTFEHR
CC1G_14245_Ccin_YAK ----THEIVAVKVIKNKPAYFNQSMMEVTILEMLNKTCD---P-NDEHHLLRLRDSFIHR
AqueK110_Aque_DYRK1 ------------------------------------------------------------
AqueK111_Aque_DYRK1 ----EREWVAIKVIKNKRAFYQQALIEKRLLELLNS-RDPE----GKYYIVSLKRSFTFR
AqueK112_Aque_DYRK2 ----TNQHIALKIIRNKKRFHHQALVEVKILDSLRK-RDRD----NQYNIIHMFDYFYFR
AqueK113_Aque_DYRK2 ----MQTHIALKVVRNEKRFHRQAQEEVKILEHLRR-QDKD----NAHNIIHMIDHFTFR
AqueK114_Aque_HIPK ----TSEIVAIKILKSTPSYAKQGQMEVDVLSKLSR-LSPD-----EGSFVKAYESFQHH
AqueK115_Aque_PRP4 ----SSQEVAIKIIRNNEMMHKTGMAELEILKKLNA-TD---P-DDKFHCIRLFSNFFHK
AqueK116_Aque_PRP4 ----SSQEVAIKIIRNNEMMHKTGMAELEILKKLNA-TD---P-DDKFHCIRLFSNFFHK
DYRK2_b_Smoe_DYRK2 ----YKVPRAIKIIRNKKQFTQQAFIEINLLEFLRN-KAAE-E-GVDYNIVTIYESFEFR
DYRK2_a_Smoe_DYRK2 ----YKVPRAIKIIRNKKQFTQQAFIEINLLEFLRN-KAAE-E-GVDYNIVTIYESFEFR
DYRKP-2_Smoe_DYRKP ----------MKIIKNNKDFFDQSLDEIKLLKYINK-HD---P-ADKYHILRLYDYFYHR
DYRKP-1_Smoe_DYRKP ----TGMDVCMKIIKNNKDFFDQSLDEIKLLKYINK-HD---P-ADKYHILRLYDYFYHR
PRP4_e_Smoe_PRP4 ---ECEQEVAIKIPRKNDLMLRSAKSELQILKKVAE-PEAT---NKDNHCVKLLDSFVYR
PRP4_d_Smoe_PRP4 ---ECQQEVAIKIPRKNDLMLRSAKSELQILKKVAE-PEAT---NKDNHCVKLLDSFVYR
PRP4_b_Smoe_PRP4 ---GEPEEVAIKIIRSNETMFKAGQMELIILNKLAG-AD---L-ENKRHCVRLLSSFEYR
PRP4_a_Smoe_PRP4 ---GEPEEVAIKIIRSNETMFKAGQMELIILNKLAG-AD---L-ENKRHCVRLLSSFEYR
PRP4_c_Smoe_PRP4 ------------------------------------------------------------
YAK_b_Smoe_YAK ----ENGYVAVKVIKNQPAYYQQALVEIEILKMLNRDFD---P-DNQHHIVRILDWFLFE
YAK_a_Smoe_YAK ----ENGYVAVKVIKNQPAYYQQALVEIEILKMLNRDFD---P-DNQHHIVRILDWFLFE
YAK_d_Smoe_YAK -------IVTRKTVDDK-------------------------------------------
GK031_Glam_DYRK1 ----NNAYVAIKIMKAGKLFTHKGREEAEIMSLLSD-ED---P-PIS---CKFIESFMQG
GK034_Glam_DYRK2 ----EQQFVALKIIKNRKRFQRQGLVEVKILELLRD-NDPN----GDQCCVKVLSSFYFR
GK033_Glam_DYRK2 ----DNVTYCLKIIKQEKEFFDQAIDEVHLLELLKD-ID---P-NNNINIIKIHDYFYFR
GK032_Glam_DYRK2 ----EGKDVCLKVVNNEKDTLDQCLNEIRLLTYINK-HD---P-TGK-HFVRMTDYFYYG
PRP4_Hsap_PRP4 QHLCLVFEPLSMNLREVLKKYGKD-------VG----LHIKAVRSYSQQLFLALKLLKR-
HIPK4_Hsap_HIPK LKFYLVFELLEQNLFEFQKE-NNF-------AP----LPARHIRTVTLQVLTALARLK--
HIPK3_Hsap_HIPK NHTCLVFEMLEQNLYDFLKQ-NKF-------SP----LPLKVIRPILQQVATALKKLK--
HIPK2_Hsap_HIPK NHTCLVFEMLEQNLYDFLKQ-NKF-------SP----LPLKYIRPVLQQVATALMKLK--
HIPK1_Hsap_HIPK NHTCLVFEMLEQNLYDFLKQ-NKF-------SP----LPLKYIRPILQQVATALMKLK--
smi35A_Dmel_DYRK2 KHLCITFELMSLNLYELIKK-NNY-------NG----FSMSLIRRFCNSIVKCLRLLY--
mnb_Dmel_DYRK1 NHLCLVFELLSYNLYDLLRN-TNF-------RG----VSLNLTRKFAQQLCTALLFLSTP
Dyrk3_Dmel_DYRK2 NHTCITFELLSINLYELIKK-NGF-------KG----FSLQLVRKFAHSLLQCLDALY--
CG17090_Dmel_HIPK NHTCLVFEMLEQNLYDFLKQ-NKF-------SP----LPLKYIRPILEQVLTALLKLK--
PRP4_Mmus_PRP4 QHLCLVFEPLSMNLREVLKKYGKD-------VG----LHIKAVRSYSQQLFLALKLLKR-
HIPK4_Mmus_HIPK LKFYLVFELLEQNLFEFQKE-NNF-------AP----LPARHIRTVTLQVLRALARLK--
HIPK3_Mmus_HIPK NHTCLVFEMLEQNLYDFLKQ-NKF-------SP----LPLKVIRPVLQQVATALKKLK--
HIPK2_Mmus_HIPK NHTCLVFEMLEQNLYDFLKQ-NKF-------SP----LPLKYIRPVLQQVATALMKLK--
HIPK1_Mmus_HIPK NHTCLVFEMLEQNLYDFLKQ-NKF-------SP----LPLKYIRPILQQVATALMKLK--
DYRK4_Mmus_DYRK2 NHLCITFELLGINLYELMKN-NSF-------HG----FNLSIVRRFTFSILKCLHMLY--
DYRK3_Mmus_DYRK2 NHVCMAFELLSIDLYELIKK-NKF-------QG----FSVQLVRKFAQSILQSLDALH--
DYRK2_Mmus_DYRK2 NHICMTFELLSMNLYELIKK-NKF-------QG----FSLPLVRKFAHSILQCLDALH--
DYRK1B_Mmus_DYRK1 NHLCLVFELLSYNLYDLLRN-THF-------RG----VSLNLTRKLAQQLCTALLFLATP
DYRK1A_Mmus_DYRK1 NHLCLVFEMLSYNLYDLLRN-TNF-------RG----VSLNLTRKFAQQMCTALLFLATP
mbk-2_Cele_DYRK2 NHKCITFELLSINLYELIKR-NKF-------QG----FSLMLVRKFAYSMLLCLDLLQ--
mbk-1_Cele_DYRK1 AHLCLVFELLSYNLYDLLKN-TSF-------RG----VSLNLARKFAQQLGKTLLFLSSP
hpk-1_Cele_HIPK SHTCLVFEMLEQNLYDFLKQ-NKF-------MP----LPLNAIRPILFQVLTALLKLK--
F22D6.5_Cele_PRP4 NHLCLVFENLSMNLRELLKKYGQK-------DG----LHLKAVRSYAQQLLLALRLLKK-
C36B7.2_Cele_DYRK2 GFHYVVTDLFDTSVKKYIKE-HHP-------NG----IALENVAAMGRKILKGLVFLHE-
C36B7.1_Cele_DYRK2 GHHFIVLENYQTDLASYLCGRSKL-------T-------PREYIPMIKSIVHGLKFLHQ-
DYRK4_Hsap_DYRK2 NHFCITFELLGINLYELMKN-NNF-------QG----FSLSIVRRFTLSVLKCLQMLS--
DYRK3_Hsap_DYRK2 NHVCMAFELLSIDLYELIKK-NKF-------QG----FSVQLVRKFAQSILQSLDALH--
DYRK2_Hsap_DYRK2 NHICMTFELLSMNLYELIKK-NKF-------QG----FSLPLVRKFAHSILQCLDALH--
DYRK1B_Hsap_DYRK1 NHLCLVFELLSYNLYDLLRN-THF-------RG----VSLNLTRKLAQQLCTALLFLATP
DYRK1A_Hsap_DYRK1 NHLCLVFEMLSYNLYDLLRN-TNF-------RG----VSLNLTRKFAQQMCTALLFLATP
YAK1_Scer_YAK NHLCLVFELLSNNLYELLKQ-NKF-------HG----LSIQLIRTFTTQILDSLCVLK--
Dyrk1_Ddis_DYRK1 NHLCIVTELLSYNLYDLLRN-THF-------HG----VSLNLIKKFAHQILTALFFMSTP
Dyrk2_Ddis_DYRK2 NHLILTFELLSMNLYDFLKV-NHF-------QG----YNLNLVRRFGAQILTSLRFLS--
Prp4_Ddis_PRP4 NHLCIVFEPMSMSLHQLIKKYGKD-------IG----LSLNAVRVYAKQLFLALKHIKN-
YakA_Ddis_YAK MHLCIVFELLSVNLFELIKQ-NNF-------RG----LSTNLIKVFLIQILDALIVLA--
22349_Tthe_YAK NHFCLVFEMLELSLYDYLKN-TKF-------CG----FSFSVIAQWTKSILEGMVIAE--
10580_Tthe_DyrkP EHLFIVTELLKDNLYEFYKF-NRE-------NETQPYFTLGRLQKITQQILIGLDYIHS-
22423_Tthe_DyrkP EHLFIITELLEENLYEFYKF-NRE-------NEQQRYFTVGRLQKITQQILVALDFIHS-
5306_Tthe_DYRK2 NHVCLVFELLSINLYDLLRN-NKF-------QG----LSLELIRRFAIQLLNAISFLK--
5356_Tthe_DYRK2 SHVGLL-------------------------------------------------FLT--
5655_Tthe_DYRK2 KHVI----------------------------------------------LNSINFLR--
15575_Tthe_PRP4 KHMCLVFECFAMNLRDALKEYGKG-------KG----FSLDVVRSYAYQIFVALTHLKK-
DYRK1_Spur_DYRK1 NHLCLVFELLSYNLYDLLRN-TNF-------RG----VSLNLTRKFAQQMCTALLFLATP
DYRK2_Spur_DYRK2 NHICITFELLSMNLYELIKK-NKF-------QG----FSLQLVRKFAHSLLQCLEGLH--
DYRK4_Spur_DYRK2 NHLCITFELLGMNLYELIKK-NNF-------QG----FSVALIRRFAFSLLQCLRMLH--
HIPKa_Spur_HIPK NHTCLVFELLEKNLYDFLKQ-SKF-------RP----LPLKHIRPTLQQVLVALLKLK--
HIPKb_Spur_HIPK ------------------------------------------------------------
PRP4_Spur_PRP4 QHLCLVFEPLSMNLREVLKRYGKD-------VG----LHIKAVRSYTQQLFLALKLLKR-
CG7028_Dmel_PRP4 QHLCMVFEPLAMNLREVLKKYGKN-------VG----LHIKAVRSYTQQLFLALKLLKK-
CC1G_13957_Ccin_DYRK2 NHLCIATELLSINLYELIKA-NGF-------VG----FTTALIRRFTTQMLMSLSLMR--
CC1G_04865_Ccin_PRP4 GHLCLVFENLSMNLREVVKRFGKD-------VG----LNIRAVRAYAHQLFLALSLLRK-
CC1G_14245_Ccin_YAK SHLCLVFELLSSNLYELIKQ-NQF-------QG----LSTQLVKVFMAQLLDALTVLK--
AqueK110_Aque_DYRK1 ------------------------------------------------------------
AqueK111_Aque_DYRK1 GHLCFVFELLSYNLYELLRN-TNF-------RG----VSLNLTRKFAQQLCTALLFLSTH
AqueK112_Aque_DYRK2 NHLCITFELMGMNLYELIKK-NNF-------QG----FSISLIRRFAYSMLQCLKILY--
AqueK113_Aque_DYRK2 NHVCITFELLSMNLYELIKK-NKF-------QG----FSLALVRKFAHSILQCLDSLY--
AqueK114_Aque_HIPK GHICIVFELLHINLYDYLKQ-SRF-------DP----LPLKYIRPIAQQVLCCLEKLA--
AqueK115_Aque_PRP4 NHLCLVFESMSMNIREVLRKYGKN-------IG----LHIKAVRSYSQQLLLALKLMKR-
AqueK116_Aque_PRP4 NHLCLVFESMSMNIREVLRKYGKN-------IG----LHIKAVRSYSQQLLLALKLMKR-
DYRK2_b_Smoe_DYRK2 GHLCLSFAVHDISLFDMLKK-NHF-------EG----FNLSLVKCFARQVLVSLQFLH--
DYRK2_a_Smoe_DYRK2 GHLCLSFAVHDISLFDMLKK-NHF-------EG----FNLSLVKCFARQVLVSLQFLH--
DYRKP-2_Smoe_DYRKP EHLFIVCELLRANLYEFHKY-NRD-------SGGEVYFTMPRLQSITRQCLEALEFLHG-
DYRKP-1_Smoe_DYRKP EHLFIVCELLRANLYEFHKY-NRD-------SGGEVYFTMPRLQSITRQCLEALEFLHG-
PRP4_e_Smoe_PRP4 EHLCLVMESLDLNLRQITNKYGRN-------RG----INLKTICVYAHQLMVALQHLAH-
PRP4_d_Smoe_PRP4 EHLCLVMEFLDLNLRQITNKYGRN-------RG----INLKTICVYAHQLMVALQHLAH-
PRP4_b_Smoe_PRP4 NHLCLVFESLHMNLREILKKFGRN-------IG----ISLAAVRSYARQLFTALKHLRN-
PRP4_a_Smoe_PRP4 NHLCLVFESLHMNLREILKKFGRN-------IG----ISLAAVRSYARQLFTALKHLRN-
PRP4_c_Smoe_PRP4 EHLCLVMESLDLNLRQITNKYGRN-------RG----INLKTICVYAHQLMVALQHLAH-
YAK_b_Smoe_YAK QHLCIAFELLSHNLYELIKV-NRH-------RG----ISLHLLRIFTKQILDSLGVLR--
YAK_a_Smoe_YAK QHLCIAFELLSHNLYELIKV-NRH-------RG----ISLHLLRIFTKQILDSLGVLR--
YAK_d_Smoe_YAK -------------------------------------------MSIMTQLLEALQVLE--
GK031_Glam_DYRK1 NHYCIVMEALGSNLYHLLKS-TKM-------QG----FPLQTIRVWARKYLTSFKKLQHE
GK034_Glam_DYRK2 SHLCIAFELLSINLYELLTK-KDL-------KG----LSLSLVRKFSLQLLIAFAYAR--
GK033_Glam_DYRK2 EHLLLKFTLLGEDLYTHFNR-REK-------KGQPNDYTIPVIRDMARQVLKALDYIHR-
GK032_Glam_DYRK2 HRLIIIFELLTSNLFSYYSA-REAALPRTLLNPLATIFTMPRLQHIARQILESLDFLHR-
PRP4_Hsap_PRP4 -CNILHADIKPDNILVNE-S------KTILKLCDFGSASHVADN---DITPYLVSRFYRA
HIPK4_Hsap_HIPK ELAIIHADLKPENIMLVDQT----RCPFRVKVIDFGSASIFSEVRYV-KEPYIQSRFYRA
HIPK3_Hsap_HIPK SLGLIHADLKPENIMLVDPV----RQPYRVKVIDFGSASHVSKTVC---STYLQSRYYRA
HIPK2_Hsap_HIPK SLGLIHADLKPENIMLVDPS----RQPYRVKVIDFGSASHVSKAVC---STYLQSRYYRA
HIPK1_Hsap_HIPK SLGLIHADLKPENIMLVDPV----RQPYRVKVIDFGSASHVSKAVC---STYLQSRYYRA
smi35A_Dmel_DYRK2 KENIIHCDLKPENILLKQRG----SS--SIKVIDFGSSCYVDRK-I---YTYIQSRFYRS
mnb_Dmel_DYRK1 ELNIIHCDLKPENILLCNPK----RS--AIKIVDFGSSCQLGQR-I---YHYIQSRFYRS
Dyrk3_Dmel_DYRK2 KNDIIHCDMKPENVLLKQQG----RS--GIKVIDFGSSCFENQR-I---YTYIQSRFYRA
CG17090_Dmel_HIPK QLGLIHADLKPENIMLVDPV----RQPYRVKVIDFGSASHVSKTVC---NTYLQSRYYRA
PRP4_Mmus_PRP4 -CNILHADIKPDNILVNE-S------KTILKLCDFGSASHVADN---DITPYLVSRFYRA
HIPK4_Mmus_HIPK ELAIIHADLKPENIMLVDQT----RCPFRVKVIDFGSASIFSEVRYV-KEPYIQSRFYRA
HIPK3_Mmus_HIPK SLGLIHADLKPENIMLVDPV----RQPYRVKVIDFGSASHVSKTVC---STYLQSRYYRA
HIPK2_Mmus_HIPK SLGLIHADLKPENIMLVDPS----RQPYRVKVIDFGSASHVSKAVC---STYLQSRYYRA
HIPK1_Mmus_HIPK SLGLIHADLKPENIMLVDPV----RQPYRVKVIDFGSASHVSKAVC---STYLQSRYYRA
DYRK4_Mmus_DYRK2 VEKIIHCDLKPENIVLYQRG----QV--TVKVIDFGSSCYEHQK-V---YTYIQSRFYRS
DYRK3_Mmus_DYRK2 KNKIIHCDLKPENILLKHHG----RS--ATKVIDFGSSCFEYQK-L---YTYIQSRFYRA
DYRK2_Mmus_DYRK2 KNRIIHCDLKPENILLKQQG----RS--SIKVIDFGSSCYEHQR-V---YTYIQSRFYRA
DYRK1B_Mmus_DYRK1 ELSIIHCDLKPENILLCNPK----RS--AIKIVDFGSSCQLGQR-I---YQYIQSRFYRS
DYRK1A_Mmus_DYRK1 ELSIIHCDLKPENILLCNPK----RS--AIKIVDFGSSCQLGQR-I---YQYIQSRFYRS
mbk-2_Cele_DYRK2 KNRLIHCDLKPENVLLKQQG----RS--GIKVIDFGSSCFDDQR-I---YTYIQSRFYRA
mbk-1_Cele_DYRK1 ELSIIHCDLKPENVLLVNAK----RS--QIRVIDFGSSCQTGHR-I---YQYIQSRFYRS
hpk-1_Cele_HIPK SLGLIHADLKPENIMLVDPQ----QQPYRVKVIDFGSASHRSKAVT---NTYLQSRYYRA
F22D6.5_Cele_PRP4 -LEFVHADIKPDNILVNE-S------KLTLKLCDFGSAGRVNEQ---ELAPYLVSRFYRA
C36B7.2_Cele_DYRK2 -HNIVHGDLKPENIMLNLAN------PNDVKLGDFGLSRFAKPY---HDHVQCQSMFYRA
C36B7.1_Cele_DYRK2 -NKIIHGDLKPANVLLNEWN------RNNLKLTDFGLSTFVNQG---PFFRDYQTLYYKA
DYRK4_Hsap_DYRK2 VEKIIHCDLKPENIVLYQKG----QA--SVKVIDFGSSCYEHQK-V---YTYIQSRFYRS
DYRK3_Hsap_DYRK2 KNKIIHCDLKPENILLKHHG----RS--STKVIDFGSSCFEYQK-L---YTYIQSRFYRA
DYRK2_Hsap_DYRK2 KNRIIHCDLKPENILLKQQG----RS--GIKVIDFGSSCYEHQR-V---YTYIQSRFYRA
DYRK1B_Hsap_DYRK1 ELSIIHCDLKPENILLCNPK----RS--AIKIVDFGSSCQLGQR-I---YQYIQSRFYRS
DYRK1A_Hsap_DYRK1 ELSIIHCDLKPENILLCNPK----RS--AIKIVDFGSSCQLGQR-I---YQYIQSRFYRS
YAK1_Scer_YAK ESKLIHCDLKPENILLCAPD----K--PELKIIDFGSSCEEART-V---YTYIQSRFYRA
Dyrk1_Ddis_DYRK1 EVDVIHCDLKPENILLRNPK----RS--AIKIIDFGSSCHSNER-M---YKYIQSRFYRS
Dyrk2_Ddis_DYRK2 KRNIIHADLKPENILLKSPT----KS--GIKLIDFGSSCFENEQ-I---FTYIQSRFYRS
Prp4_Ddis_PRP4 -SKILHADIKPDNIVVNE-A------KNTIKIVDFGSAGEIHES---EITPYLVSRFYRA
YakA_Ddis_YAK NANIIHCDLKPENILLQNVN----S--PAIKIIDFGSACYEKST-L---YTYIQSRHYRS
22349_Tthe_YAK SKQIIHCDLKPENIMLKKQL----ILNQTLKM---AT-KFSQQ-K---------------
10580_Tthe_DyrkP -LRLIHCDLKPENILMKSYS------KCQVKIIDFGSSCFIHD----HLSSYVQSRSYRA
22423_Tthe_DyrkP -LRLIHCDLKPENILMKSKP------KGEVKVIDFGSSCFIHD----HLSSYVQSRSYRA
5306_Tthe_DYRK2 ENRIIHCDLKPENVLLKQPN----KS--GIKIADFGSSCFDDQV-M---YTYIQSRYYRS
5356_Tthe_DYRK2 KANIIHCDLKPENILLKQEN----KS--GIKIVDFGSSCFENQR-V---YTYIQSRFYRA
5655_Tthe_DYRK2 KNRIIHCDLKPENILLKQAN----KS--GVKLIDFGSSCFENER-L---YTYIQSRYYRA
15575_Tthe_PRP4 -NNYIHADLKPDNLLISE-D------TKTLKMCDFGTALPIEEN---GIIKYLQSRFYRA
DYRK1_Spur_DYRK1 ELNIIHCDLKPENILLCNPK----RS--AIKIIDFGSSCQLGQR-I---YQYIQSRFYRS
DYRK2_Spur_DYRK2 RNKIIHCDLKPENILLKQQG----RS--GIKVIDFGSSCYEHQR-I---YTYIQSRFYRA
DYRK4_Spur_DYRK2 KERIIHCDLKPENILLRQKG----QS--TIKVIDFGSSCYEHQR-V---YTYIQSRFYRS
HIPKa_Spur_HIPK TLGLIHADLKPENIMLVDPV----RQPYRVKVIDFGSASHVSKAVC---STYLQSRYYR-
HIPKb_Spur_HIPK ----------------------------------------------------------RA
PRP4_Spur_PRP4 -CNILHADIKPDNILVNE-S------KSVLKLCDFGSASHVADN---DITPYLVSRFYRA
CG7028_Dmel_PRP4 -TGILHADIKPDNILVNE-N------NLILKLCDFGSASAISDN---EITPYLVSRFYRS
CC1G_13957_Ccin_DYRK2 HHRIVHCDLKPENVLLRHPA----KS--AIKVIDFGSSCLEHEK----------------
CC1G_04865_Ccin_PRP4 -ANIMHADIKPDNILVNE-Q------KNLIKLCDLGSASDASEN---EITPYLVSRFYRA
CC1G_14245_Ccin_YAK EARLIHCDLKPENILLKSLQ----S--PQIKVIDFGSACHERQT-V---YTYIQSRFYRS
AqueK110_Aque_DYRK1 ------------------------------------------------------------
AqueK111_Aque_DYRK1 DINVIHCDLKPENILLCNPK----RS--AIRIVDFGSSCQVGSR-M---FQYIQSRFYRS
AqueK112_Aque_DYRK2 RERIIHCDLKPENILLRLRG----QS--SIKVIDFGSSCYEHQR-V---YTYIQSRFYRS
AqueK113_Aque_DYRK2 RNRIIHCDLKPENILLKQPG----RS--GIKVIDFGSSCYEYQR-V---YTYIQSRFYRA
AqueK114_Aque_HIPK SLGLVHADLKPENIMLVDPQ----RYPFKVKVIDFGSAMSRDKTSP---SCYLQSRYYRA
AqueK115_Aque_PRP4 -CTILHADIKPDNILVNE-S------KLMLKLCDFGSASFIQDN---EITPYLVSRFYRA
AqueK116_Aque_PRP4 -CTILHADIKPDNILVNE-S------KLMLKLCDFGSASFIQDN---EITPYLVSRFYRA
DYRK2_b_Smoe_DYRK2 RARIIHGDLKPENILLQQPA----SP--KIKLIDFGSSCFEHER-I---YTYIQSRFYRA
DYRK2_a_Smoe_DYRK2 RARIIHGDLKPENILLQQPA----SP--KIKLIDFGSSCFEHER-I---YTYIQSRFYRA
DYRKP-2_Smoe_DYRKP -LGLIHCDLKPENILVKSYS------RCEVKVIDLGSSCFQSD----HLCSYVQSRSYRA
DYRKP-1_Smoe_DYRKP -LGLIHCDLKPENILVKSYS------RCEVKVIDLGSSCFQSD----HLCSYVQSRSYRA
PRP4_e_Smoe_PRP4 -CGILHCDIKPDNIMVTK-S------RRSIKLCDFGVAMFARDQTPSAETPYLVSPSYRA
PRP4_d_Smoe_PRP4 -CGILHCDIKPDNIMVTK-S------RRSIKLCDFGVAMFARDQTPSAETPYLVSPSYRA
PRP4_b_Smoe_PRP4 -CGVLHCDIKPDNMLVND-S------KNLLKLCDFGSAMFAGEN---EITPYLVSRFYRA
PRP4_a_Smoe_PRP4 -CGVLHCDIKPDNMLVND-S------KNLLKLCDFGSAMFAGEN---EITPYLVSRFYRA
PRP4_c_Smoe_PRP4 -CGIFHCDIKPDNIMVTK-S------RRSIKLCDFGVAMFARDQTPSAETPYLVSPSYRA
YAK_b_Smoe_YAK NAGVIHCDLKPENILLSTSL----KS-GEIKLIDFGSACLEHRT-V---YKYIQF-----
YAK_a_Smoe_YAK NAGVIHCDLKPENILLSTSL----KS-GEIKLIDFGSACLEHRT-V---YKYIQSRYYRS
YAK_d_Smoe_YAK RHGVVHRDLKPENIVLSS------QG--ELRLIDFGS-----------------------
GK031_Glam_DYRK1 SIRIIHTDCKPENTLIPFNN----TCVEDIRIVDFGSAVRYPEG---QMFLYIQSRYYRA
GK034_Glam_DYRK2 KLRIIHADVKPENILLREPD----KS--SIKVIDWGSGAMVSET-I---YSYIQSRFYRA
GK033_Glam_DYRK2 -LGITHLDLKPENLLHGDKNFIGGVNEPSVTLVDFGSSSFIFD----KMHSYIQSRSYRA
GK032_Glam_DYRK2 -LNILHLDLKHENLLLVNED----DDSFDIRLVDIGSSAFLYD----ECSTYVQSRSYRC
PRP4_Hsap_PRP4 PEIIIGK-SYDYGIDMWSVGCTLYELYTGKILFPGKTNNH--------MLKLAMDLKGK-
HIPK4_Hsap_HIPK PEILLGL-PFCEKVDVWSLGCVMAELHLGWPLYPGNNEYD--------QVRYICETQGL-
HIPK3_Hsap_HIPK PEIILGL-PFCEAIDMWSLGCVIAELFLGWPLYPGALEYD--------QIRYISQTQGL-
HIPK2_Hsap_HIPK PEIILGL-PFCEAIDMWSLGCVIAELFLGWPLYPGASEYD--------QIRYISQTQGL-
HIPK1_Hsap_HIPK PEIILGL-PFCEAIDMWSLGCVIAELFLGWPLYPGASEYD--------QIRYISQTQGL-
smi35A_Dmel_DYRK2 PEVILGL-QYGTAIDMWSLGCILAELYTGFPLFPGENEVE--------QLACIMEVLGL-
mnb_Dmel_DYRK1 PEVLLGI-QYDLAIDMWSLGCILVEMHTGEPLFSGCNEVD--------QMNKIVEVLGM-
Dyrk3_Dmel_DYRK2 PEVILGG-KYGRAIDMWSLGCILAELLSGHALFPGENESD--------QLACIIEVLGM-
CG17090_Dmel_HIPK PEIILGL-PFCEAIDMWSLGCVVAELFLGWPLYPGSSEFD--------QIRYISQTQGL-
PRP4_Mmus_PRP4 PEIIIGK-SYDYGIDMWSVGCTLYELYTGKILFPGKTNNH--------MLKLAMDLKGK-
HIPK4_Mmus_HIPK PEILLGL-PFCEKVDVWSLGCVMAELHLGWPLYPGNNEYD--------QVRYICETQGL-
HIPK3_Mmus_HIPK PEIILGL-PFCEAIDMWSLGCVIAELFLGWPLYPGALEYD--------QIRYISQTQGL-
HIPK2_Mmus_HIPK PEIILGL-PFCEAIDMWSLGCVIAELFLGWPLYPGASEYD--------QIRYISQTQGL-
HIPK1_Mmus_HIPK PEIILGL-PFCEAIDMWSLGCVIAELFLGWPLYPGASEYD--------QIRYISQTQGL-
DYRK4_Mmus_DYRK2 PEVILGH-PYNMAIDMWSLGCIMAELYTGYPLFPGENEVE--------QLACIMEVLGL-
DYRK3_Mmus_DYRK2 PEIILGC-RYSTPIDIWSFGCILAELLTGQPLFPGEDEGD--------QLACMIELLGM-
DYRK2_Mmus_DYRK2 PEVILGA-RYGMPIDMWSLGCILAELLTGYPLLPGEDEGD--------QLACMIELLGM-
DYRK1B_Mmus_DYRK1 PEVLLGT-PYDLAIDMWSLGCILVEMHTGEPLFSGSNEVD--------QMSRIVEVLGI-
DYRK1A_Mmus_DYRK1 PEVLLGM-PYDLAIDMWSLGCILVEMHTGEPLFSGANEVD--------QMNKIVEVLGI-
mbk-2_Cele_DYRK2 PEVILGT-KYGMPIDMWSLGCILAELLTGYPLLPGEDEND--------QLALIIELLGM-
mbk-1_Cele_DYRK1 PEVLLGI-AYDTKIDMWSLGCILVEMHTGEPLFAGSSEVD--------QMMKIVEVLGM-
hpk-1_Cele_HIPK PEIILGL-PFNESIDMWSLGCVIAELFLGWPLYPGSSEYD--------QIRFIIQTQGL-
F22D6.5_Cele_PRP4 PEIMLGV-RHDYAIDLWSVAVTLYEVYTGKIMFPGRTNNH--------MLKLFTDVKGK-
C36B7.2_Cele_DYRK2 PEAFVRG-RYNGATDMWSFGCTVAEMVSGKIFLAGDNCDD--------QFYLMQEVINI-
C36B7.1_Cele_DYRK2 PEVFCQG-KVSVEIDIWSLGCVAAEIVRGTPLFVGDNYFD--------QFALIQEFFGK-
DYRK4_Hsap_DYRK2 PEVILGH-PYDVAIDMWSLGCITAELYTGYPLFPGENEVE--------QLACIMEVLGL-
DYRK3_Hsap_DYRK2 PEIILGS-RYSTPIDIWSFGCILAELLTGQPLFPGEDEGD--------QLACMMELLGM-
DYRK2_Hsap_DYRK2 PEVILGA-RYGMPIDMWSLGCILAELLTGYPLLPGEDEGD--------QLACMIELLGM-
DYRK1B_Hsap_DYRK1 PEVLLGT-PYDLAIDMWSLGCILVEMHTGEPLFSGSNEVD--------QMNRIVEVLGI-
DYRK1A_Hsap_DYRK1 PEVLLGM-PYDLAIDMWSLGCILVEMHTGEPLFSGANEVD--------QMNKIVEVLGI-
YAK1_Scer_YAK PEIILGI-PYSTSIDMWSLGCIVAELFLGIPIFPGASEYN--------QLTRIIDTLGY-
Dyrk1_Ddis_DYRK1 PEILLEL-EYSFSIDMWSLGCILVEMHVGEPLFSGQNEQD--------QLTKIIEVLDL-
Dyrk2_Ddis_DYRK2 PEVILGT-KYDKSIDIWSLGCILVEIFTGVPLFPGSDEPE--------QLACIMEVLGA-
Prp4_Ddis_PRP4 PEIILGH-KYDYSIDVWSVGCCLAEFFTGKFLFPGKTNND--------MIRLFMEYRGA-
YakA_Ddis_YAK PEVLVGT-VYCASIDMWSLGCISAELFLGLPLFPGNSEYN--------QISRIVEMRGI-
22349_Tthe_YAK -----WM-IYTTAIDMWSLGCILVELFLGLPIFPGNSEYD--------QIKRIIDILGK-
10580_Tthe_DyrkP PEVILGC-KYDYKIDMWSLGCILAELWTGNVLFQNDTVQG--------LLARVIGIIGP-
22423_Tthe_DyrkP PEVIIGC-KYDYRIDIWSLGCILAELWTGNVLFQNDNIQG--------LLARVIGIIGP-
5306_Tthe_DYRK2 PEVILGI-PYGTEIDMWSFGCIIAELFLGYPIFPGEDENE--------QMGYIMELLGA-
5356_Tthe_DYRK2 PEIILGL-PYGKAIDMWSFGCIMAELYIGYPLFPGENEAE--------QFQMFMEILGI-
5655_Tthe_DYRK2 PEVILGL-PYDTSIDMWSFGCIMAELFIGYPIFPGEDEQE--------QIGYIWEIIGA-
15575_Tthe_PRP4 PEVLIGY-PPYNQIDVWSVGVTLYEIYTQKILFDGSTNNE--------MLKLIMDSRGK-
DYRK1_Spur_DYRK1 PEVLLGI-SYDMAIDMWSLGCILVEMHTGEPLFSGSNELD--------QMNKIIEVLGM-
DYRK2_Spur_DYRK2 PEVILGG-KYGMPIDMWSLGCILAELLTGYPLLPGEDEGD--------QLACMIEVMGM-
DYRK4_Spur_DYRK2 PEVILGL-PYGLPIDMWSFGCILAELYTGYPLFPGENEVE--------QLACIMEIFGL-
HIPKa_Spur_HIPK ------------------------------------------------------------
HIPKb_Spur_HIPK PEIILGL-PFCEAIDMWSLGCVVAELFLGWPLYPGASEYD--------QIRYISQTQGL-
PRP4_Spur_PRP4 PEIIIGM-NYDAAIDMWSTGCTIFELAAGKIMFPGKTNNH--------MLKLFMDLKGK-
CG7028_Dmel_PRP4 PEIILGI-PYDYGIDTWSAGCTIYELYTGKILFSGKSNNQ--------MLKFFMDVKGK-
CC1G_13957_Ccin_DYRK2 -----------------------TELYTGFPIFPGENEQE--------QLSCIMEVLGV-
CC1G_04865_Ccin_PRP4 PEIILGV-PYDPALDVWSIGCTLYELYTGKILFPGRSNNQ--------MLRLMMELKGR-
CC1G_14245_Ccin_YAK PEVLLGM-PYTAAIDMWSLGCIAVELFLGLPLFPGTSEYN--------QLTRIIEMLGM-
AqueK110_Aque_DYRK1 ------------------------------------------------------------
AqueK111_Aque_DYRK1 PEVLLGI-PYDLAIDMWSLGCILVEMHTGEPLFSGKDEID--------QMSKIVEVLGI-
AqueK112_Aque_DYRK2 PEVILGL-PYSMAIDMWSLGCILAELYTGYPLFPGENEVE--------QLACIIEIFGL-
AqueK113_Aque_DYRK2 PEVILGG-KYGMSIDMWSFGCILAELLTGYPLFPGEDEGD--------QLACMMEVLGL-
AqueK114_Aque_HIPK PEVILGV-NFNEGIDMWSLGCVLAELYLGWPLFPGASEFD--------QITYICQTLGP-
AqueK115_Aque_PRP4 PE----------------------------------------------------------
AqueK116_Aque_PRP4 PEIIIGC-KYDYGIDMWSVGATLYELYTGQILFPGKSNNE--------MLKLNMELKGK-
DYRK2_b_Smoe_DYRK2 PEVILGL-PYDMMIDVWSFACILAELFTGYPLFPGEDEVE--------QLAYMMEVLGT-
DYRK2_a_Smoe_DYRK2 PEVILGL-PYDMMIDVWSFACILAELFTGYPLFPGEDEVE--------QLAYMMEVLGT-
DYRKP-2_Smoe_DYRKP PEVILGL-PYDQKIDIWSLGCILAELCSGNVLFQNDSLAT--------LLARVVGIIGP-
DYRKP-1_Smoe_DYRKP PEVILGL-PYDQKIDIWSLGCILAELCSGNVLFQNDSLAT--------LLARVVGIIGP-
PRP4_e_Smoe_PRP4 PEIILGVAPYSHAIDMWSAGCCLYELYTGKFLFPVATNNG--------LLKQQMELKGA-
PRP4_d_Smoe_PRP4 PEIILGVAPYSHPIDMWSAGCCLYELYTGKFLFPVATNNG--------LLKQQMELKGA-
PRP4_b_Smoe_PRP4 PEIILGL-PYDHALDMWSVGCCLYELYTGKVLFPGSTNND--------MLRLHMELKGP-
PRP4_a_Smoe_PRP4 PEIILGL-PYDHALDMWSVGCCLYELYTGKVLFPGSTNND--------MLRLHMELKGP-
PRP4_c_Smoe_PRP4 PEIILGVAPYSHQIDMWSAGCCLYELYTGKFLFPVATNNG--------LLKQQMELKGA-
YAK_b_Smoe_YAK ------------------------------------------------------------
YAK_a_Smoe_YAK PEVVLGH-PYTTAIDMWSLGCVAAELFLGLPLFSGESEYD--------LLRRMIDTLGCQ
YAK_d_Smoe_YAK ------------------------------------------------------------
GK031_Glam_DYRK1 PEVLLLQ-PYDYQIDIWSIAAILFEMHTGKVLFPAKSSEI--------LCYMMVDILGY-
GK034_Glam_DYRK2 PEVILGL-PYGQEIDIWSIGCVLCELYTGLPIFPGDDERD--------QLGKICELLGM-
GK033_Glam_DYRK2 PEVILAT-PYDSRADIWSFGCVVCELLTGRVLFPNYSVAT--------ILSRICSLIGP-
GK032_Glam_DYRK2 PEVILGL-PYDGRADVWSLGPILTELITGKVMFPIPQKADEDHKPYASMLAKLIGIIGP-
PRP4_Hsap_PRP4 MPNKMIRKGVFKDQ------HFDQN-------------LNFM--------Y---------
HIPK4_Hsap_HIPK PKPHLLHAACKAHH------FFKRN-------------PHPDA-------A---------
HIPK3_Hsap_HIPK PGEQLLNVGTKSTR------FFCKE-------------TDMSH-------S---------
HIPK2_Hsap_HIPK PAEYLLSAGTKTTR------FFNRD-------------TDSPY-------P---------
HIPK1_Hsap_HIPK PAEYLLSAGTKTTR------FFNRD-------------PNLGY-------P---------
smi35A_Dmel_DYRK2 PPKVLISVARRRRL------FFDSR-------------DAPR--------C---------
mnb_Dmel_DYRK1 PPKYLY------------------------------------------------------
Dyrk3_Dmel_DYRK2 PNKNILAS----------------------------------------------------
CG17090_Dmel_HIPK PTEHMLNS----------------------------------------------------
PRP4_Mmus_PRP4 MPNKMIRKGVFKDQ------HFDQN-------------LNFM--------Y---------
HIPK4_Mmus_HIPK PKPHLLHAARKAHH------FFKRN-------------PHPDA-------T---------
HIPK3_Mmus_HIPK PGEQLLNVGTKSTR------FFCRE-------------TDMSH-------S---------
HIPK2_Mmus_HIPK PAEYLLSAGTKTTR------FFNRD-------------TDSPY-------P---------
HIPK1_Mmus_HIPK PAEYLLSAGTKTTR------FFNRD-------------PNLGY-------P---------
DYRK4_Mmus_DYRK2 PPAHFTQTASRRQV------FFDSK-------------GLPK--------N---------
DYRK3_Mmus_DYRK2 PPQKLLEQSKRAKY------FINSK-------------GLPR--------Y---------
DYRK2_Mmus_DYRK2 PSQKLLDASKRAKN------FVSSK-------------GYPR--------Y---------
DYRK1B_Mmus_DYRK1 PPAPMLEQAPKARK------YFERL-------------PGG-GW------T---------
DYRK1A_Mmus_DYRK1 PPAHILDQAPKARK------FFEKL-------------PDG-TW------S---------
mbk-2_Cele_DYRK2 PPPKSLETAKRART------FITSK-------------GYPR--------Y---------
mbk-1_Cele_DYRK1 PPKEMLDIGPKTHK------YFDKT-------------EDG-IY------Y---------
hpk-1_Cele_HIPK PPTSMLESASKLHR------FFKEV-------------KSESPNHTNVGGS---------
F22D6.5_Cele_PRP4 YPNKLVRKSQFKDT------HFDVN-------------CNLL--------Y---------
C36B7.2_Cele_DYRK2 PPPVFFDTFYTNYY------FFSTLK------------EAPK--------H---------
C36B7.1_Cele_DYRK2 PSRKLFNTWGGIHQ------FYTEY-------------FFPR--------H---------
DYRK4_Hsap_DYRK2 PPAGFIQTASRRQT------FFDSK-------------GFPK--------N---------
DYRK3_Hsap_DYRK2 PPPKLLEQSKRAKY------FINSK-------------GIPR--------Y---------
DYRK2_Hsap_DYRK2 PSQKLLDASKRAKN------FVSSK-------------GYPR--------Y---------
DYRK1B_Hsap_DYRK1 PPAAMLDQAPKARK------YFERL-------------PGG-GW------T---------
DYRK1A_Hsap_DYRK1 PPAHILDQAPKARK------FFEKL-------------PDG-TW------N---------
YAK1_Scer_YAK PPSWMIRE----------------------------------------------------
Dyrk1_Ddis_DYRK1 PPSHMIDSSPKAKK------FFTKD-------------PINSTY------Q---------
Dyrk2_Ddis_DYRK2 PPKSVIDNSTRKDI------FFEDD-------------GTPK--------P---------
Prp4_Ddis_PRP4 FSKKMLKKSEFVSN------HFNEN-------------LVFM--------K---------
YakA_Ddis_YAK FPSDLLDKGKSSTR------YFHRH-------------LGSNSD------DNNNNNNNNN
22349_Tthe_YAK PTNEVIEQGRFKNK------FFKCL-------------DGE--Y------I---------
10580_Tthe_DyrkP IPEWMFQEGRLVNN------FFTNK-------------RLLY--------Q---------
22423_Tthe_DyrkP FPEWMMKEGRLVQN------FFTRE-------------KLLY--------M---------
5306_Tthe_DYRK2 PDSEFLKKCSRKKY------FFDQN-------------DQPL--------Q---------
5356_Tthe_DYRK2 PEEEFVENCPRRNV------FFENN-------------KTPK--------V---------
5655_Tthe_DYRK2 PSKDFLQNCTRRKY------FFNED-------------YTPK--------L---------
15575_Tthe_PRP4 FNKKMLQNGKYVEE------YFDQN-------------YNFK--------Y---------
DYRK1_Spur_DYRK1 PPNHIIEQAPKAHK------YFIKT-------------EK--TW------V---------
DYRK2_Spur_DYRK2 PSQNLIDTSKRSKN------FINSK-------------GQPR--------Y---------
DYRK4_Spur_DYRK2 PPP---------------------------------------------------------
HIPKa_Spur_HIPK ------------------------------------------------------------
HIPKb_Spur_HIPK PAEHLLSAATKTTR------FFKRD-------------IESNF-------P---------
PRP4_Spur_PRP4 MPHKIIRKGILRDK------HFDPN-------------CNFK--------Y---------
CG7028_Dmel_PRP4 IPNRIIVT----------------------------------------------------
CC1G_13957_Ccin_DYRK2 PDKEYINRSSRKKL------FFDTN-------------GAPR--------P---------
CC1G_04865_Ccin_PRP4 FNTKIIKKAKFGET------YFDEL-------------GAFE--------S---------
CC1G_14245_Ccin_YAK PPLSMLNSGKQTK-----------------------------------------------
AqueK110_Aque_DYRK1 -----------RDR------FFERE-------------SGG-TW------V---------
AqueK111_Aque_DYRK1 PPPHVLERSARRDR------FFERE-------------SGG-TW------V---------
AqueK112_Aque_DYRK2 PDPALLAEAQRKKL------FFDSR-------------GNPR--------C---------
AqueK113_Aque_DYRK2 PSQKMIESTKRGRT------FFSSK-------------GHPR--------Y---------
AqueK114_Aque_HIPK LPHHLMRNITKATR------FFNCD-------------PVTS------------------
AqueK115_Aque_PRP4 ------------------------------------------------------------
AqueK116_Aque_PRP4 MSHKMVRKGMFREN------HFDSS-------------FNFL--------Y---------
DYRK2_b_Smoe_DYRK2 PPLSLISQAKRKKM------FFDSD-------------NKPR--------I---------
DYRK2_a_Smoe_DYRK2 PPLSLISQAKRKKM------FFDSD-------------NKPR--------I---------
DYRKP-2_Smoe_DYRKP LDPEMVARGRESYK------FLTKN-------------SKLY--------E---------
DYRKP-1_Smoe_DYRKP LDPEMVARGRESYK------FLTKN-------------GKLY--------E---------
PRP4_e_Smoe_PRP4 FPKAMLKKGAFTGM------HFNEN-------------FEFR--------Q---------
PRP4_d_Smoe_PRP4 FPKAMLKKGAFTGM------HFNEN-------------FEFR--------Q---------
PRP4_b_Smoe_PRP4 FPKKMLRKAMFTAQ------HFDQD-------------LNFH--------A---------
PRP4_a_Smoe_PRP4 FPKKMLRKAMFTAQ------HFDQD-------------LNFH--------A---------
PRP4_c_Smoe_PRP4 FPKAMLKKGAFTGM------HFNEN-------------FEFR--------Q---------
YAK_b_Smoe_YAK ------------------------------------------------------------
YAK_a_Smoe_YAK PPDQLLRDSANTSK------YFKTV-------------SAAPPS------S--------G
YAK_d_Smoe_YAK ------------------------------------------------------------
GK031_Glam_DYRK1 PPKEMIMDEEQKQISNSLKRYFKMRKQEDAELFHLNENAFPH--------Q---------
GK034_Glam_DYRK2 PPNDMIFKSPRKND------FFVNI-------------GTGM--------G---------
GK033_Glam_DYRK2 IPRDMIMSGRMGQR------VLTFG-------------LVPY--------E---------
GK032_Glam_DYRK2 IPRDMILAGRESHK------LFTKD-------------LFLF--------E---------
PRP4_Hsap_PRP4 ----I-EVD---KV----------------TE---RE-K-----------------V---
HIPK4_Hsap_HIPK ---NPWQLK---SS----------------ADY---L-----------------------
HIPK3_Hsap_HIPK ----GWRLK---TL----------------EEH---E-----------------------
HIPK2_Hsap_HIPK ----LWRLK---TP----------------DDH---E-----------------------
HIPK1_Hsap_HIPK ----LWRLK---TP----------------EEH---E-----------------------
smi35A_Dmel_DYRK2 ----I-TNT---------------------------------------------------
mnb_Dmel_DYRK1 ------------------------------------------------------------
Dyrk3_Dmel_DYRK2 ------------------------------------------------------------
CG17090_Dmel_HIPK ------------------------------------------------------------
PRP4_Mmus_PRP4 ----I-EVD---KV----------------TE---RE-K-----------------V---
HIPK4_Mmus_HIPK ---NPWQLK---SS----------------ADY---L-----------------------
HIPK3_Mmus_HIPK ----GWRLK---TL----------------EEH---E-----------------------
HIPK2_Mmus_HIPK ----LWRLK---TP----------------DDH---E-----------------------
HIPK1_Mmus_HIPK ----LWRLK---TP----------------EEH---E-----------------------
DYRK4_Mmus_DYRK2 ----I-NNN---------------------------------------------------
DYRK3_Mmus_DYRK2 ----C-SVS---TQ----------------TDG---R-----------------------
DYRK2_Mmus_DYRK2 ----C-TVT---TL----------------SDG---S-----------------------
DYRK1B_Mmus_DYRK1 ----L-RRT---K------------------EL---R-----------------------
DYRK1A_Mmus_DYRK1 ----L-KKT---K------------------DG---K-----------------------
mbk-2_Cele_DYRK2 ----C-TAT---SM----------------PDG---S-----------------------
mbk-1_Cele_DYRK1 ----C-KKT---R------------------DG---Y-----------------------
hpk-1_Cele_HIPK ----YYRLK---TV----------------EEY---E-----------------------
F22D6.5_Cele_PRP4 ----Q-EVD---KV----------------TE---RN-K-----------------I---
C36B7.2_Cele_DYRK2 ----I--V---ITD----------------HG-P----------------------IV-S
C36B7.1_Cele_DYRK2 ----C--FEWLNPF----------------NG-D-R--T-----------------MEIE
DYRK4_Hsap_DYRK2 ----I-TNN---------------------------------------------------
DYRK3_Hsap_DYRK2 ----C-SVT---TQ----------------ADG---R-----------------------
DYRK2_Hsap_DYRK2 ----C-TVT---TL----------------SDG---S-----------------------
DYRK1B_Hsap_DYRK1 ----L-RRT---K------------------EL---R-----------------------
DYRK1A_Hsap_DYRK1 ----L-KKT---K------------------DG---K-----------------------
YAK1_Scer_YAK ------------------------------------------------------------
Dyrk1_Ddis_DYRK1 ----L-KKN---E------------------KL---K-----------------------
Dyrk2_Ddis_DYRK2 ----V-KNS---TT----------------------------------------------
Prp4_Ddis_PRP4 ----Q-EID---NI----------------EK---TV-R----------------KV--P
YakA_Ddis_YAK GKPYYYTLK---SE----------------EDY---Q-----------------------
22349_Tthe_YAK ----F-KTK---------------------QEF---E-----------------------
10580_Tthe_DyrkP ----D-VFEEGEPS----------------QN-I-ND-T-----------------SDMP
22423_Tthe_DyrkP ----E-VFEEADQS----------------QA-I-GD-Q-----------------QDGQ
5306_Tthe_DYRK2 ----I-PNS---------------------------------------------------
5356_Tthe_DYRK2 ----V-KNS---------------------------------------------------
5655_Tthe_DYRK2 ----I-PNS---------------------------------------------------
15575_Tthe_PRP4 ----T-YVD---KQ----------------TN---QK-Y-----------------T---
DYRK1_Spur_DYRK1 ----L-KRS---R------------------DG---K-----------------------
DYRK2_Spur_DYRK2 ----C-TVT---TL----------------PDG---T-----------------------
DYRK4_Spur_DYRK2 ------------------------------------------------------------
HIPKa_Spur_HIPK ------------------------------------------------------------
HIPKb_Spur_HIPK ----LWRLK---NP----------------EEH---E-----------------------
PRP4_Spur_PRP4 ----V-EVD---KV----------------TE---RE-K-----------------V---
CG7028_Dmel_PRP4 ------------------------------------------------------------
CC1G_13957_Ccin_DYRK2 ----V-VNS---------------------------------------------------
CC1G_04865_Ccin_PRP4 ----V-ERD---RL----------------TG---SD-I-----------------T---
CC1G_14245_Ccin_YAK ------------------------------------------------------------
AqueK110_Aque_DYRK1 ----L-KRQ---R------------------DG---R-----------------------
AqueK111_Aque_DYRK1 ----L-KRQ---R------------------DG---R-----------------------
AqueK112_Aque_DYRK2 ----V-TNS---------------------------------------------------
AqueK113_Aque_DYRK2 ----T-TVN---IN----------------PDG---T-----------------------
AqueK114_Aque_HIPK ----TWSLK---SI----------------SQY---T-----------------------
AqueK115_Aque_PRP4 ------------------------------------------------------------
AqueK116_Aque_PRP4 ----H-TVD---KV----------------TQ---KE-K-----------------V---
DYRK2_b_Smoe_DYRK2 ----V-PNS---------------------------------------------------
DYRK2_a_Smoe_DYRK2 ----V-PNS---------------------------------------------------
DYRKP-2_Smoe_DYRKP ----R-N-Q---------------------------------------------------
DYRKP-1_Smoe_DYRKP ----R-N-Q---------------------------------------------------
PRP4_e_Smoe_PRP4 -------LD---PV----------------TK---LE-T-----------------L---
PRP4_d_Smoe_PRP4 -------LD---PV----------------TK---LE-T-----------------L---
PRP4_b_Smoe_PRP4 ----I-EED---PV----------------TK---K-------------------TI--N
PRP4_a_Smoe_PRP4 ----I-EED---PV----------------TK---KV-QFCIFPVYSFLHLLSFQTI--N
PRP4_c_Smoe_PRP4 -------LD---PV----------------TK---LE-T-----------------L---
YAK_b_Smoe_YAK ------------------------------------------------------------
YAK_a_Smoe_YAK GMAV-YQFL---TV----------------SEV---K-A---------------------
YAK_d_Smoe_YAK ------------------------------------------------------------
GK031_Glam_DYRK1 ----V-VPDSYLLN----------------KS-V-IE-M-----------------AEAQ
GK034_Glam_DYRK2 ----V-AGV---SEGGNPIFSGNLQQLSSVNEYLQATGR-----------------GAGG
GK033_Glam_DYRK2 ----H-D-E--------------------------KN-----------------------
GK032_Glam_DYRK2 ----T-R-E---AI----------------LG-N-RD-K-----------------AEGL
PRP4_Hsap_PRP4 ----------TVMSTI-NPTKDLLADLI---G------C--Q--RLPEDQRKKVHQLKDL
HIPK4_Hsap_HIPK AET-KVRP--LERRKYMLK---SLDQIETVN-GGSVASRLTFPDREALAEHADLKSMVEL
HIPK3_Hsap_HIPK AET-GMKS--KEARKYIFN---SLDDVAHVN-T---VMD--LEGSDLLAEKADRREFVSL
HIPK2_Hsap_HIPK AET-GIKS--KEARKYIFN---CLDDMAQVN-M---TTD--LEGSDMLVEKADRREFIDL
HIPK1_Hsap_HIPK LET-GIKS--KEARKYIFN---CLDDMAQVN-M---STD--LEGTDMLAEKADRREYIDL
smi35A_Dmel_DYRK2 -----------KGRKR-SPGSKSLAHIL----------------------HCQDRYFIDF
mnb_Dmel_DYRK1 ------------------------------------------------------LKFKDL
Dyrk3_Dmel_DYRK2 -----------------------------------------------------DPLFLNF
CG17090_Dmel_HIPK ------------------------------------------------------REFIDL
PRP4_Mmus_PRP4 ----------TVMSTI-NPTKDLLADLI---G------C--Q--RLPEDQRKKVHQLKDL
HIPK4_Mmus_HIPK AET-KVRP--LERRKYMLK---SLDQIETVN-GGGAVSRLSFPDREALAEHADLKSMVEL
HIPK3_Mmus_HIPK AET-GMKS--KEARKYIFN---SLDDIVHVN-T---VMD--LEGGDLLAEKADRREFVNL
HIPK2_Mmus_HIPK AET-GIKS--KEARKYIFN---CLDDMAQVN-M---TTD--LEGSDMLVEKADRREFIDL
HIPK1_Mmus_HIPK LET-GIKS--KEARKYIFN---CLDDMAQVN-M---STD--LEGTDMLAEKADRREYIDL
DYRK4_Mmus_DYRK2 -----------RGGKR-YPDSKDLTMVV----------------------KTYDSSFLDF
DYRK3_Mmus_DYRK2 VVLLGGRS--RRGKKRGPPGSKDWATAL---------------------KGCGDYLFIEF
DYRK2_Mmus_DYRK2 VVLNGGRS--RRGKLRGPPESREWGNAL---------------------KGCDDPLFLDF
DYRK1B_Mmus_DYRK1 -----------K-DYQ-GPGTRRLQEVLGVQ-TGGP-GG--RRAGEPGHSPADYLRFQDL
DYRK1A_Mmus_DYRK1 -----------R-EYK-PPGTRKLHNILGVE-TGGP-GG--RRAGESGHTVADYLKFKDL
mbk-2_Cele_DYRK2 VVLAGARS--KRGKMRGPPASRSWSTAL---------------------KNMGDELFVDF
mbk-1_Cele_DYRK1 -----------RHTYK-APGARKLHEILGVT-SGGP-GG--RRLGEPGHSVEDYSKFKDL
hpk-1_Cele_HIPK ASSSTAKS--KETRKYIFN---VIDDISRVC-Y---GFE--SDPVEHLCDRIDRQEFVDV
F22D6.5_Cele_PRP4 ----------TVLANL-KPTRDLESELI---A------G--Q--RLSRDQMDQIQAFRTL
C36B7.2_Cele_DYRK2 FI--YTKA--AD-HRK-IPGATPIG---------------------SFFTKTEQKPFNNF
C36B7.1_Cele_DYRK2 PH--YKLA--HP-SRK-PPLTSSLV---------------------SKLPGGNQKFLARF
DYRK4_Hsap_DYRK2 -----------RGKKR-YPDSKDLTMVL----------------------KTYDTSFLDF
DYRK3_Hsap_DYRK2 VVLVGGRS--RRGKKRGPPGSKDWGTAL---------------------KGCDDYLFIEF
DYRK2_Hsap_DYRK2 VVLNGGRS--RRGKLRGPPESREWGNAL---------------------KGCDDPLFLDF
DYRK1B_Hsap_DYRK1 -----------K-DYQ-GPGTRRLQEVLGVQ-TGGP-GG--RRAGEPGHSPADYLRFQDL
DYRK1A_Hsap_DYRK1 -----------R-EYK-PPGTRKLHNILGVE-TGGP-GG--RRAGESGHTVADYLKFKDL
YAK1_Scer_YAK -------------------------------------------------------CLIHF
Dyrk1_Ddis_DYRK1 -----------T-NVE--FCKKKLSEIIGVE-TGGP-QS--RRKNEPGHALVDYLKFLDL
Dyrk2_Ddis_DYRK2 ------------GELY-TIGTKSFKDSI----------------------RSGDEDFDNF
Prp4_Ddis_PRP4 ----------HDITK---PTKDILQFLL---P------K---NVSIPDQDMKKLIQLKDL
YakA_Ddis_YAK RDS-KTTL--LPSKKYFN--YKTLPEIIQNYGF---KKS--MSPQDIEKEKQHRIVFTDF
22349_Tthe_YAK ISE-GIQL--KESKTYFQV--ACLNDLKNYM-YN--SQF--RRNEDDTKNNRQFDLFLDL
10580_Tthe_DyrkP GR--RQKS--GKIQIL-VPKKSNLR---------------------ARL-KTDDLMFLDF
22423_Tthe_DyrkP RQ--KIKT--GKIQIL-VPKHSNLK---------------------ARL-RTEDHLFIDF
5306_Tthe_DYRK2 -----------RGKIR-MPNSKNWKSVI----------------------GCTDDNFIDF
5356_Tthe_DYRK2 -----------RGKIR-TPATKHINYYL----------------------RCPDENFIDF
5655_Tthe_DYRK2 -----------KGKIR-VPNSKILKAVL----------------------QTESEDFTDF
15575_Tthe_PRP4 ----------TIITYGDIPKKDIYRLLQ---E------N---KDGINLENQKKLSQFKDF
DYRK1_Spur_DYRK1 -------------KYK-SPRTRKLQDILGVE-LGGP-GG--RRAGEPGHTVSDPHKFKDP
DYRK2_Spur_DYRK2 TVLNGGRS--RRGKVRGPPGSKDLVKAL---------------------KGCDDPLFLDF
DYRK4_Spur_DYRK2 ------------------------------------------------------------
HIPKa_Spur_HIPK ------------------------------------------------------------
HIPKb_Spur_HIPK TET-SVKS--KEARKYIFN---CLDDIAGVN-L---PTD--LEGSDYLAEKADRREFVEL
PRP4_Spur_PRP4 ----------TVMTVI-NPTKDLTTELL---G------Y--Q--RLPEDQQRKVLQLKDV
CG7028_Dmel_PRP4 -------------------------------------------------------QLKDL
CC1G_13957_Ccin_DYRK2 -----------KGRRR-RPGSKTLAQVL----------------------RCNDEEFIDF
CC1G_04865_Ccin_PRP4 ----------RKIHIQ-KPTRDLRARLM---P------S--SSVKLNDEETKMLANFIDL
CC1G_14245_Ccin_YAK --------------------------------------------------LNNRAAFIDF
AqueK110_Aque_DYRK1 -----------KDHHR-RPGSRSLYEVLGGD-KGGP-GG--LRKGDSGHTPNDYYKFRDL
AqueK111_Aque_DYRK1 -----------KDHHR-RPGSRSLYEILGGD-KGGP-GG--LRKGDSGHTPNDYYKFRDL
AqueK112_Aque_DYRK2 -----------KGKKR-RPGSKDLSSAI----------------------KTSDLLFLDF
AqueK113_Aque_DYRK2 ASYTGGRS--RRGKFRGPPGTKDMSRAL---------------------KGCDDPQFLDF
AqueK114_Aque_HIPK QET-GIQS--KESRKYIFR---SLLDMNHLPPL---AAG--IDNREAILTSVDRMEFISL
AqueK115_Aque_PRP4 ------------------------------------------------------------
AqueK116_Aque_PRP4 ----------VVMSSF-SPQRDLLADLV---G------S--Q--SPSEAHLRKIHHFKDF
DYRK2_b_Smoe_DYRK2 -----------SGTRH-FPSTKDLRMVV----------------------GCSDKSFVNF
DYRK2_a_Smoe_DYRK2 -----------SGTRH-FPSTKDLRMVV----------------------GCSDKSFVNF
DYRKP-2_Smoe_DYRKP ------ET--SRMEYL-IPKKTTLA---------------------HRL-PMGDQGFLEF
DYRKP-1_Smoe_DYRKP ------ET--SRMEYL-IPKKTTLA---------------------HRL-PMGDQGFLEF
PRP4_e_Smoe_PRP4 ----------RSMASF-NVKTSCISDLT-------------------GEDGALMARFKNL
PRP4_d_Smoe_PRP4 ----------RSMASF-NVKTSCISDLT-------------------GEDGALMARFKNL
PRP4_b_Smoe_PRP4 ----------RMITNV--KPKDI-STLI---S------S----SGGSDEDAKNLLNFKLL
PRP4_a_Smoe_PRP4 ----------RMITNV--KPKDI-STLI---S------S----SGGSDEDAKNLLNFKLL
PRP4_c_Smoe_PRP4 ----------RSMASF-NVKTSCLSDLT-------------------GEDGALMSRFKNL
YAK_b_Smoe_YAK ------------------------------------------------------------
YAK_a_Smoe_YAK RES-KEP---LVGKSYFR--HTKLEDIISKYPY---KSS--LSAEEQEAERQRRLSFLDF
YAK_d_Smoe_YAK ------------------------------------------------------------
GK031_Glam_DYRK1 KE--RIFGRPLRELIR-NPVMTQYE---------------------GH-TSADYEEFEEF
GK034_Glam_DYRK2 SEVPGIRL----RTTH-KVNSKTLSGVL----------------------NA-PDDFISF
GK033_Glam_DYRK2 ----------RQHFYF-TPQQGLLEYWL---F------G---ERC-ANL-TDEEVLFSDF
GK032_Glam_DYRK2 RHA-EIKG--EDYVYV-LPKKTTIKAML----------G---WDS--HP-EYCDDLFLDF
PRP4_Hsap_PRP4 LDQILMLDPAKRISINQAL----Q
HIPK4_Hsap_HIPK IKRMLTWESHERISPSAALRHPFV
HIPK3_Hsap_HIPK LKKMLLIDADLRITPAETLNHPFV
HIPK2_Hsap_HIPK LKKMLTIDADKRITPIETLNHPFV
HIPK1_Hsap_HIPK LKKMLTIDADKRITPLKTLNHQFV
smi35A_Dmel_DYRK2 LQRCLEWDPAERMTPDEAAHHEFL
mnb_Dmel_DYRK1 ILRMLDFDPKTRVTPYYALQHNFF
Dyrk3_Dmel_DYRK2 IRGCLEWDADKRLTPSEALKHPWL
CG17090_Dmel_HIPK LKRMLTIDQERRLTPAEALNHSFT
PRP4_Mmus_PRP4 LDQILMLDPAKRISINQAL----Q
HIPK4_Mmus_HIPK IKRMLTWESHERISPSAALRHPFV
HIPK3_Mmus_HIPK LKKMLLIDADLRITPIETLNHPFV
HIPK2_Mmus_HIPK LKKMLTIDADKRVTPIETLNHPFV
HIPK1_Mmus_HIPK LKKMLTIDADKRITPLKTLNHQFV
DYRK4_Mmus_DYRK2 LRRCLVWEPSLRMTPEQALKHAWI
DYRK3_Mmus_DYRK2 LKRCLQWDPSARLTPAQALRHPWI
DYRK2_Mmus_DYRK2 LKQCLEWDPAVRMTPGQALRHPWL
DYRK1B_Mmus_DYRK1 VLRMLEYEPAARISPLGALQHGFF
DYRK1A_Mmus_DYRK1 ILRMLDYDPKTRIQPYYALQHSFF
mbk-2_Cele_DYRK2 LKRCLDWDPETRMTPAQALKHKWL
mbk-1_Cele_DYRK1 IKRMLQFDPKQRISPYYVVRHPFL
hpk-1_Cele_HIPK LKKMLVLNPDFRITPAEGLESKFV
F22D6.5_Cele_PRP4 LDGMLILDPSKRTTCNEALKHPFF
C36B7.2_Cele_DYRK2 ILKVFKWMPASRITAKQALDHPFF
C36B7.1_Cele_DYRK2 LMRCFEWDPTERIKSSFILNHPFF
DYRK4_Hsap_DYRK2 LRRCLVWEPSLRMTPDQALKHAWI
DYRK3_Hsap_DYRK2 LKRCLHWDPSARLTPAQALRHPWI
DYRK2_Hsap_DYRK2 LKQCLEWDPAVRMTPGQALRHPWL
DYRK1B_Hsap_DYRK1 VLRMLEYEPAARISPLGALQHGFF
DYRK1A_Hsap_DYRK1 ILRMLDYDPKTRIQPYYALQHSFF
YAK1_Scer_YAK LGGVLNLNPLERWTPQQAMLHPFI
Dyrk1_Ddis_DYRK1 IEKMLIYDPQKRITPLEALQHSFF
Dyrk2_Ddis_DYRK2 ILDCLKWEPSQRITAEQGLKHDWI
Prp4_Ddis_PRP4 IEKCTILDPEKRITPFEA-----L
YakA_Ddis_YAK INGLLQLDPNERWSPMQAKEHPFI
22349_Tthe_YAK ATQLLELNPRKRVKASIAMQHPFL
10580_Tthe_DyrkP VKSLLQIDRTRRPSAKEALQHPWL
22423_Tthe_DyrkP VRQCLQIDFTRRPTAKEALSHPWF
5306_Tthe_DYRK2 IKKCLVWEPSQRLTPRDALLHPWI
5356_Tthe_DYRK2 VSKCFTWKNHERMSPAEALVHDWI
5655_Tthe_DYRK2 LTKCFVWEPQKRLKPSDALMHPWI
15575_Tthe_PRP4 LDKCLQLDPKNRITPEEALEHPFL
DYRK1_Spur_DYRK1 ILRMLEYDPASRIKPYYALQHSFF
DYRK2_Spur_DYRK2 LKRCLEWDPSSRMTPSQALRHSWL
DYRK4_Spur_DYRK2 -----------------------H
HIPKa_Spur_HIPK -----------------------C
HIPKb_Spur_HIPK LKKMLTIDPDKRITPLEALNHPFV
PRP4_Spur_PRP4 LDRCLMLDPSKRISINEVLRHSFI
CG7028_Dmel_PRP4 LENMFALDPAKRISLNQALVHPFI
CC1G_13957_Ccin_DYRK2 IAKCLVWDPERRMKPQAAMRHPFV
CC1G_04865_Ccin_PRP4 LDKCLMLDPARRITPREALSHPFI
CC1G_14245_Ccin_YAK CKGLLDLNPVTRWTPQQARLHPFI
AqueK110_Aque_DYRK1 VLQMLDYDPETRIKPLAALKHPFF
AqueK111_Aque_DYRK1 VLQMLDYDPETRIKPLAALKHPFF
AqueK112_Aque_DYRK2 IRRCLVWSASERMKPEEALQHAWI
AqueK113_Aque_DYRK2 LRHCLEWDPAIRMTPPQALRHPWL
AqueK114_Aque_HIPK LSRMLSLDPTQRIRPLSALQSPFI
AqueK115_Aque_PRP4 -----------------------I
AqueK116_Aque_PRP4 LDKIFILDPTKRLSINQALQHPFI
DYRK2_b_Smoe_DYRK2 LSCCLKWDKEQRMTPQQLLKHEWI
DYRK2_a_Smoe_DYRK2 LSCCLKWDKEQRMTPQQLLKHEWI
DYRKP-2_Smoe_DYRKP VAFLLQINPKNRPSAAEALKHPWL
DYRKP-1_Smoe_DYRKP VAFLLQINPKNRPSAAEALKHPWL
PRP4_e_Smoe_PRP4 LERMLTLDPSKRITPDEALKHPFL
PRP4_d_Smoe_PRP4 LERMLTLDPSKRITPDEALKHPFL
PRP4_b_Smoe_PRP4 LEKIFILDPEKRLTVSQALNHPFI
PRP4_a_Smoe_PRP4 LEKIFILDPEKRLTVSQALNHPFI
PRP4_c_Smoe_PRP4 LERMLTLDPSKRITPDEALKHPFL
YAK_b_Smoe_YAK ------------------CNPSCY
YAK_a_Smoe_YAK LRGLVRFDPKSRWTPHQAAQHPFV
YAK_d_Smoe_YAK -----------------------A
GK031_Glam_DYRK1 LSKILVYDPKRRWTIDEALNSRFL
GK034_Glam_DYRK2 ISLFLQWDPQRRCTPEVAMSHPWI
GK033_Glam_DYRK2 CRQALIVDPIKRPTAAMLLEHPFI
GK032_Glam_DYRK2 IETIMRIDPRKRPTAAEALEHPWL