NIK_Hsap ATHQ--LRLGRGSFGE-VHRMEDKQTG-FQ-----CAVKKVRLE----------------
NIK_Mmus T-HQ--PRVGRGSFGE-VHRMKDKQTG-FQ-----CAVKKVRLE----------------
COT_Mmus YRNIGSGFVPRGAFGK-VYLAQDMKTK-KR-----MACKLIPID----------------
COT_Hsap YRNIGSDFIPRGAFGK-VYLAQDIKTK-KR-----MACKLIPVD----------------
DDB0229972_Ddis ----------LGKYDK-VILVILSQQY-LQNQVNIFPIKLIDRERINL------------
DDB0229973_Ddis IKLC--EQIGSGGSGCTVHRCT--VDG-FT-----CAVKVLKLKNTSP------------
DDB0230010_Ddis FRDK--IKLGTGAFGN-VFYAIRKSDS-SP-----VAIKVLME-RTKK------------
IfkA_Ddis WKKG--SCIERKSNYS-VYRGVDEDTD-RK-----LICKIVNLNIDDRSSSSLTSLSNSN
IfkA~b_Ddis FEEI--EMIGKGGFGV-VVKSRNKLDC-RY-----YAIKKIKTKGYTDSNQ---------
CC1G_01579_Ccin ------------------------------------------------------------
AqueK223_Aque ------EILGEGGFGT-VYACSDRYYQ-TM-----FAIKCNKHNSE--EK----------
STE-Un_a_Smoe PLFY--EEIGFGASGAEVRKCS--IRQ-LD-----SAV--VKESSD--------------
STE-Un_b_Smoe YRNR--IRIAHGAFAQ-IYKATVNEEDGPR----LVVLKTVELPKGPYEP----------
NIK_Hsap ---------------------------------------------VFRAEELMACAG-LT
NIK_Mmus ---------------------------------------------VFRVEELVACAG-LS
COT_Mmus ---------------------------------------------QFKPSDVEIQAC-FR
COT_Hsap ---------------------------------------------QFKPSDVEIQAC-FR
DDB0229972_Ddis ------------------------------------------IHQNILSNEFQLLKS-LK
DDB0229973_Ddis ------------------------------------------FLVEQFISEITIMVK-LS
DDB0230010_Ddis --------------------------------------------DSPIIPELYIHSA-CN
IfkA_Ddis NNNSNNNNNNNNNNNNNNNNNNNNNNNNNLSIDVVELKKRLIEKVKMIQKEIESMKY-LG
IfkA~b_Ddis -----------------------------------------EPLTNKLLREVTTLSR-LH
CC1G_01579_Ccin ------------------------------------------------------------
AqueK223_Aque --------------------------------------------VRNMNLECRVLDHIGH
STE-Un_a_Smoe ---------------------------------------------GGWLSELRIHCSIGE
STE-Un_b_Smoe ------------------------------------------CKFFDVYSEVQILEKFLG
NIK_Hsap SPRIVPLYGAVR------------------------------------------------
NIK_Mmus SPRIVPLYGAVR------------------------------------------------
COT_Mmus HENIAELYGAVL------------------------------------------------
COT_Hsap HENIAELYGAVL------------------------------------------------
DDB0229972_Ddis HSGIVNYIGMIN------------------------------------------------
DDB0229973_Ddis HQNIAKYLGHRL------------------------------------------------
DDB0230010_Ddis HSNIVTYIESYL------------------------------------------------
IfkA_Ddis NPYIIKYLGTNFQ-----------------------------------------------
IfkA~b_Ddis HQFVVRYYQAWIEKS-CDSFQSLEEGNEDLSGDLETDASEDWFMQSSINSRSIISRDSYS
CC1G_01579_Ccin ------------------------------------------------------------
AqueK223_Aque HTHITQLFGAMIDKNVSA------------------------------------------
STE-Un_a_Smoe HPNVVAFYGHQLSFESAA---S--------------------------------N-----
STE-Un_b_Smoe EPKISQLLDYGL------------------------------------------------
NIK_Hsap ------------------------------------------------------------
NIK_Mmus ------------------------------------------------------------
COT_Mmus ------------------------------------------------------------
COT_Hsap ------------------------------------------------------------
DDB0229972_Ddis ------------------------------------------------------------
DDB0229973_Ddis ------------------------------------------------------------
DDB0230010_Ddis ------------------------------------------------------------
IfkA_Ddis ------------------------------------------------------------
IfkA~b_Ddis GLSTSNSNVGGVNNTAGGGDSVSNANSNKSMIVGNSNKKLTLSSSNTSSSSSLLSNNKSK
CC1G_01579_Ccin ------------------------------------------------------------
AqueK223_Aque ------------------------------------------------------------
STE-Un_a_Smoe ------------------------------------------------------------
STE-Un_b_Smoe ------------------------------------------------------------
NIK_Hsap ------------------------------------------------------------
NIK_Mmus ------------------------------------------------------------
COT_Mmus ------------------------------------------------------------
COT_Hsap ------------------------------------------------------------
DDB0229972_Ddis ------------------------------------------------------------
DDB0229973_Ddis ------------------------------------------------------------
DDB0230010_Ddis ------------------------------------------------------------
IfkA_Ddis ------------------------------------------------------------
IfkA~b_Ddis ILNTSKSTSTNTSTSTSTSNTNKNKKISKKKKSKLSPLMKPKNKKNKNNGESEQSSSDSE
CC1G_01579_Ccin ------------------------------------------------------------
AqueK223_Aque ------------------------------------------------------------
STE-Un_a_Smoe ------------------------------------------------------------
STE-Un_b_Smoe ------------------------------------------------------------
NIK_Hsap ------------------------------------------------------------
NIK_Mmus ------------------------------------------------------------
COT_Mmus ------------------------------------------------------------
COT_Hsap ------------------------------------------------------------
DDB0229972_Ddis ------------------------------------------------------------
DDB0229973_Ddis ------------------------------------------------------------
DDB0230010_Ddis ------------------------------------------------------------
IfkA_Ddis ------------------------------------------------------------
IfkA~b_Ddis NGENGMKSRIIENASDSYSDDDNNNNNNNDNNNNYHSDNESDSFSGSISMSDGNGSGYEA
CC1G_01579_Ccin ------------------------------------------------------------
AqueK223_Aque ------------------------------------------------------------
STE-Un_a_Smoe ------------------------------------------------------------
STE-Un_b_Smoe ------------------------------------------------------------
NIK_Hsap ------------------------------------------------------------
NIK_Mmus ------------------------------------------------------------
COT_Mmus ------------------------------------------------------------
COT_Hsap ------------------------------------------------------------
DDB0229972_Ddis ------------------------------------------------------------
DDB0229973_Ddis ------------------------------------------------------------
DDB0230010_Ddis ------------------------------------------------------------
IfkA_Ddis ------------------------------------------------------------
IfkA~b_Ddis TDDEDIINNSGSFDENENDDDDEEDDDDEYDEEDDDYETFDFQDKSRVVSNNSKLSTSSS
CC1G_01579_Ccin ------------------------------------------------------------
AqueK223_Aque ------------------------------------------------------------
STE-Un_a_Smoe ----------GA------------------------------------------------
STE-Un_b_Smoe ------------------------------------------------------------
NIK_Hsap ------EGPWVNIFMELLEGGSLGQL---VKEQ---------GC--LPEDR--ALYYLGQ
NIK_Mmus ------EGPWVNIFMELLEGGSLGQL---IKQM---------GC--LPEDR--ALYYLGQ
COT_Mmus ------WGDTVHLFMEAGEGGSVLEK---LESC---------GP--MREFE--IIWVTKH
COT_Hsap ------WGETVHLFMEAGEGGSVLEK---LESC---------GP--MREFE--IIWVTKH
DDB0229972_Ddis ------DNTGFGIVQEFYENGSLSDI---YNRS---------GA--FQESL--VAKYTLQ
DDB0229973_Ddis ------SGNQLWLFMEFYPH-SLKDV---ITK--------RTSP--FPATE--VIWMALE
DDB0230010_Ddis ------CKGHVWIILEYCDGGTVRDL---LQATCTPGNPNNLQL--FEETL--IAYIITE
IfkA_Ddis -----EGQNTLYIFQEYNSTLTLQQK---ILSN---------GIG-FEESQ--VKKFTYQ
IfkA~b_Ddis RKKPPKETHTLYIQMEYCSKKTLKTL---IDNV---------G-G-IAEEE--AFRLLRQ
CC1G_01579_Ccin ------------VLMEYCEGGSLESINERIIEK---------NVT-VEERI--AGQVAEG
AqueK223_Aque ---CVYEGQKFKMLMELATNGSLDEL---LFDPDT----NEPSG--LPFNQ--SLFYLQQ
STE-Un_a_Smoe --NKKLDAPQLVIFMEYVKGGSLDNV---ITRFS------KDGCLYTPPRL--AINIAES
STE-Un_b_Smoe ------ESETFVLVLKHYKC-SLRAW---RLNQGGLHSHKSGKS--FVDRLPLYLEVYAA
: : ::
NIK_Hsap ALEGLEYLHSRR--ILHGDVKADNVLLSSDGS------------------------HAAL
NIK_Mmus ALEGLEYLHTRR--ILHGDVKADNVLLSSDGS------------------------RAAL
COT_Mmus ILKGLDFLHSKK--VIHHDIKPSNIVFMST--------------------------KAVL
COT_Hsap VLKGLDFLHSKK--VIHHDIKPSNIVFMST--------------------------KAVL
DDB0229972_Ddis ILEALGYIHSQG--IVHRNLKSNNVLLAKGGK-------------------------VKI
DDB0229973_Ddis IAKGLEFLHTQKNPIIHRDLKPGNIMCSLDDKGR--------------------VCSIRV
DDB0230010_Ddis LLEGLVYLRSKG--IIHRDLKSRNILLTRKGK-------------------------VKI
IfkA_Ddis LLLGLLYLHSQH--IPHRDFKSHNIFFNQSTS------------------------KMLL
IfkA~b_Ddis IVEGLNHIHSQQ--IIHRDLKPANIFIDNEQ-------------------------NVKI
CC1G_01579_Ccin ILQGLSYLFSQD--LIHNSLEPANILFSKGG-------------------------LVKL
AqueK223_Aque ILYAVHFLHQRA--ILHLDLKCANVLLFNEGR------------------------TVKL
STE-Un_a_Smoe VAQGLVWLHSRG--IIHRDIKSSNILVDLDSPDN--------------------RPVVKI
STE-Un_b_Smoe VLDAVKVLEAHN--VVHYDLKCDNVLLEPVDSVISEEEFWDPTWPPSEENSHPLPFRVCL
.: : : : * ..: *:. :
NIK_Hsap CDFGHAVCLQPDGLGKS-----------------------------------LLTGDYIP
NIK_Mmus CDFGHALCLQPDGLGKS-----------------------------------LLTGDYIP
COT_Mmus VDFGLSVKMTEDV----------------------------------------YLPKDLR
COT_Hsap VDFGLSVQMTEDV----------------------------------------YFPKDLR
DDB0229972_Ddis SDFAIGIRSSAIE---------------------------------------PSIRFSLN
DDB0229973_Ddis CDFDTSKELGNG----------------------------------------VTLK-TCI
DDB0230010_Ddis ADFGLATTCS-LG---------------------------------------RG-RTRMC
IfkA_Ddis SNYGGRNIKIFDHFE-------------------------------------K-L-NSLK
IfkA~b_Ddis GDFGLATSGAPVSKSDD-LNSSTSNTANNINLSSSTNSTAQQTPMWDLNDENLSM-TGGV
CC1G_01579_Ccin SGHPWAEIV-HQGA---------------------------------------H----TS
AqueK223_Aque TDFGSAVRLDESGG--------------------------------------CHIQ-SNK
STE-Un_a_Smoe CDFDSAVPVGSSSIHTCYL-----------------------------AHHGLPLTDVCV
STE-Un_b_Smoe ADFGQSKASVFQGG--------------------------------------ECTV-RNR
..
NIK_Hsap -GTETHMA---------------------------PEVVLG----------RSCDAKVDV
NIK_Mmus -GTETHMA---------------------------PEVVMG----------KPCDAKVDI
COT_Mmus -GTEIYMS---------------------------PEVILC----------RGHSTKADI
COT_Hsap -GTEIYMS---------------------------PEVILC----------RGHSTKADI
DDB0229972_Ddis -GYPFWTS---------------------------PEVLSM----------KPFNHKVDS
DDB0229973_Ddis -GTPCYMA---------------------------AEVLNVADGG-----NSGYSLKADI
DDB0230010_Ddis -GTMGRIA---------------------------PEVIRR----------EPYDTQSDI
IfkA_Ddis -NLNSWISSTNNSINNINNINNNNNNNNNNINTTTTQNQ--I--------NNEIDRREDI
IfkA~b_Ddis -GTPFYCC---------------------------PEILEKN--------TKHYGTKVDM
CC1G_01579_Ccin -RRLYYMS---------------------------PEQIQGL---------ATSRGPSDI
AqueK223_Aque GLTPYFSA---------------------------PEAIRCE----------YVSFSADI
STE-Un_a_Smoe -GTPRWIA---------------------------PEVLGAMY-T-----RQQYGLEADM
STE-Un_b_Smoe -GTEYVKS---------------------------PEMLKLLRTGGDASLDTCVGKAVDV
. .: *
NIK_Hsap WSSCCMMLHMLNGCHPWTQFF-RG--PLC-----LKI---------A----------S-E
NIK_Mmus WSSCCMMLHMLNGCHPWTQYF-RG--PLC-----LKI---------A----------S-E
COT_Mmus YSLGATLIHMQTGTPPWVKRYPRSAYPSY-----LYI--------IH----------K-Q
COT_Hsap YSLGATLIHMQTGTPPWVKRYPRSAYPSY-----LYI--------IH----------K-Q
DDB0229972_Ddis WSIGCLIMELIVGHPPFSHLGPMEAL--I-----E-I--------IN----------P-S
DDB0229973_Ddis WSFAMLCFEIISLLPPYHQFQHLQSI--------EMI--------IN----------G-T
DDB0230010_Ddis YSLGCLIIEMAEGTVPYGKDSSLKAL--F-----YTA--------IH----------Q-Y
IfkA_Ddis INLGIVVLEMLCGSDLA-NN--QTVLIYL---AQLNLLNNQQQNQNF----------I-Q
IfkA~b_Ddis YSLGIIFFEMCFQFQTQ-ME--RSNILRD-----LRD--------NL----------K-F
CC1G_01579_Ccin WSAGVVLLEFVQKEFPWGSD--LSPVEIM-----MNI--------VH----------G-E
AqueK223_Aque WSVLCCLVEMITGHLPWCYNGLRDPHNII-----MLA--------GH----------YCD
STE-Un_a_Smoe WSFGCFISELLTLNVPYAGIGDNEIHNHIKVSVVVTI--------LSSPSHALVGQAG-E
STE-Un_b_Smoe WGLGCLLYELLAAEYLLYDED--WMRFFI-----RVT--------TN----------SE-
. .:
NIK_Hsap PPPV---------------REIPPS---CAPLTAQAIQEGLRKEPIHRVSAAELGGKVNR
NIK_Mmus PPPI---------------REIPPS---CAPLTAQAIQEGLRKEPVHRASAMELRRKVGK
COT_Mmus APPL---------------EDIAGD---CSPGMRELIEAALERNPNHRPKAADL------
COT_Hsap APPL---------------EDIADD---CSPGMRELIEASLERNPNHRPRAADL------
DDB0229972_Ddis TTILP--------N--CL-DENEQS--LFSLELNQFLELCFKKEPSDRASVHDL------
DDB0229973_Ddis CPPL------------PT-DLIQPK---LLQPLIELLVTCIDLNPNHRPNASQL------
DDB0230010_Ddis --KLP--------N--PK-K--------YTKEFVDFLYLCLNPDPFKRPTPEML------
IfkA_Ddis PPPL---------------QYQLQQQ---YDLIKEIEQKTHPSSPISN-NAKDFL-----
IfkA~b_Ddis PPGF---------------ESTKPD-------QTQIIRSLLSRDPTQRPSTKQL------
CC1G_01579_Ccin PPTL---------------ADKTTDDAVWSNDLKDFLKQMLVNAPSGRKTAMEL------
AqueK223_Aque AEPLK--------YFRCLVPEGIET---EDPRILELFEKVFKRNPKDRPTALKL------
STE-Un_a_Smoe RPSLTWKLDEIVLE--PA-VGGDKD---CLDALIRLYESCTELDPGKRPTAQEA------
STE-Un_b_Smoe -ELIT----------NEK-AEKVGN---F-GPVVEFIRFVLVRDPCRRPTLDEV------
. * .
NIK_Hsap ALQQVGGLKSPWR
NIK_Mmus ALQEVGGLKSPWK
COT_Mmus -------LKHEAL
COT_Hsap -------LKHEAL
DDB0229972_Ddis -------LRHPWL
DDB0229973_Ddis -------VQKLTK
DDB0230010_Ddis -------LHHTFL
IfkA_Ddis ------SLCFTIN
IfkA~b_Ddis -------LESGLL
CC1G_01579_Ccin -------LEHSWI
AqueK223_Aque -------LEHELI
STE-Un_a_Smoe -------LS--SL
STE-Un_b_Smoe -------MIH--L
: