NIK_Hsap         MAVMEMACPGA-------------------PGS----AVGQQKELPKAK-----------
NIK_Mmus         MAVMEVACPGT-------------------PGS----AVGQQKELAKAK-----------
COT_Mmus         MEYMSTGSDEKEE--IDLLIK---------------------------------------
COT_Hsap         MEYMSTGSDNKEE--IDLLIK---------------------------------------
DDB0229972_Ddis  MEQEDQQYEEDS----SQFNK-----NNYVPDD-----NSGEKEQPATT-----------
DDB0229973_Ddis  MELSEPKQRFESL--LSLFEDVA---NKRYSGDFSVKKNINAPQVPPRSYSLFNVTGGNV
DDB0230010_Ddis  MKSFLNKNKNSKK--IIILDD---------------------------------------
IfkA_Ddis        MANSNNNNNSNNNNNNSTFGY-SNSECSGSSGN----LLMT--LDPDNN-----------
CC1G_01579_Ccin  MTHLDPPITSS-------------------TRS----A----------------------
AqueK223_Aque    MIPVLRV-----------------------TGM----ADQQQQQQPGGG-----------
STE-Un_a_Smoe    MDGTGSRNSGN------------------------------RSKLGVES-----------
STE-Un_b_Smoe    MVEPWLAFSAG-------------------GSD----AIPGLSEGIIFP-----------
                 *

NIK_Hsap         --------------------------------------------------------EKTP
NIK_Mmus         --------------------------------------------------------EKTQ
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  --------------------------------------------------------TEIT
DDB0229973_Ddis  SSYNNQQQQQNNNNNNNNNNNNNNNNNNNNNNNNNNSGEISSNNSTPSILFSPTPTSTAP
DDB0230010_Ddis  ------------------------------------------------------------
IfkA_Ddis        ---QSQL-------------------------------------------------EEIE
CC1G_01579_Ccin  --------------------------------------------------------QI--
AqueK223_Aque    --------------------------------------------------------GRPS
STE-Un_a_Smoe    --------------------------------------------------------RRCK
STE-Un_b_Smoe    --------------------------------------------------------EREE


NIK_Hsap         PLGKKQ-------------------------------SSVYK------------------
NIK_Mmus         SLGKKQ-------------------------------SCIFK------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  T-TTTT------------------------------------------------------
DDB0229973_Ddis  P-APPQPTTPPNTGFHNRPLSININQQPIGGVNNNNNNNNKDS----------PSN-KPL
DDB0230010_Ddis  ------------------------------------------------------------
IfkA_Ddis        C-L----------------------------------KSIYRD----------EFE-ELP
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    S-TKRV-------------------------------DSQQQL----------QRQ-DSG
STE-Un_a_Smoe    T---------------------------------------------------LGS-----
STE-Un_b_Smoe    SA--LQ-------------------------------ACLFRNKSRIREFFSEARVSKEP


NIK_Hsap         ------------------------------------LE--AVE-----KSPVFCGKW-EI
NIK_Mmus         ------------------------------------LE--AVE-----KSPVFCGKW-EI
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  RLSGSPPTASINGNQIEQLQRELRNEKEAHQQTKYLLN--SF-ADENKKLSNDCQLW-RA
DDB0230010_Ddis  --------------------NDFSKYQQRY-----DLQNQNI---EIVSSPLQNIRS-QQ
IfkA_Ddis        -------------------------------------------------TEAVCRRF-KI
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    FLSGA-------------------------------------------PTPVTPSRP-EM
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    VLV---------------------------RVLVGSKE--GIEKWLKVSGPASCCLWVEI


NIK_Hsap         -----------------------------------------LND-VITKGTA--------
NIK_Mmus         -----------------------------------------LND-VITKGTA--------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  ----------------------------------------KYFK-LLTKNTK-LKVIFDH
DDB0230010_Ddis  -----------------------------------------INDGVQMSGSIQSDLSSSD
IfkA_Ddis        TLIPHPTNQYQNFCAVRLYVKYSPNYPVSLPTIELEKVRGLSDD-LIGELSF--------
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    -----------------------------------------NAN-QPQQGGG--------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    -----------------------------------------SDD-RLTRGIV--------


NIK_Hsap         ----KEGSE---------------------------------------------AGPAAI
NIK_Mmus         ----KDGSE---------------------------------------------GGPPAI
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  -----------------------------------------------------------T
DDB0229973_Ddis  FQSIMNESD---------------------------------------------SVPGEG
DDB0230010_Ddis  NFTSSGGFG---------------------------------------------GG----
IfkA_Ddis        ----LLSQK---------------------------------------------MAPGEI
CC1G_01579_Ccin  -------------------------------------------------------NPPPL
AqueK223_Aque    ----QSGGH---------------------------------------------LVPRDS
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    ----PSSGEEFFTSQVKLAYRFRAVTASYLTILAGTFVVLSAYRKSRFELRENGGGTEAH


NIK_Hsap         SII------------------------------AQAECENSQEFS---------------
NIK_Mmus         SII------------------------------AQAECENSQEFS---------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  SLV------------------------------HSTSYNSSSSSSSGGGGNI--------
DDB0230010_Ddis  ------------------------------------------------------------
IfkA_Ddis        IIF------------------------------E--LCQAVQEFLL-----L--------
CC1G_01579_Ccin  AI-------------------------------------QTTEWS---------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    SLFVKWLLIMPATAFHQLLCMVEPGGALAEFQIVLRQLVDSTNFAD-----VGFRHLDFS


NIK_Hsap         ------------------------------------------------------------
NIK_Mmus         ------------------------------------------------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  ---------TPRKLS---------------------------------------------
DDB0230010_Ddis  ------------------------------------------------------------
IfkA_Ddis        ---------YNKETVSLHEEMIKRLNTNINRVNSSDDINNNNNNNNDDDDDNDDYDDSDD
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    CWLAHFPFVLTFEGVDLL-VMTRDLRWTIMRFDCSEGKLKI-------------------


NIK_Hsap         ----------------------------------------PTFSERIF-IAGSKQYSQS-
NIK_Mmus         ----------------------------------------PTFSERIF-IAGSQQYSQS-
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  ----------------------LAG---------------------------GGKFDDAP
DDB0230010_Ddis  --------------------------GNSSSNTSNRNS--DNSTQRPLMVDIGLEYKYR-
IfkA_Ddis        ENSDSDYDDYDDSDDENSDDEFYSD---------------------------DEDYNT--
CC1G_01579_Ccin  ----------------------------------------DDRFEEVE-IIASRNRR---
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    ------------------------GKGRFSADTSRESLGVSFYSEKAF-QVHEWELWDS-


NIK_Hsap         ---------ESLDQ--------------IPNNVAH-------------------ATEGKM
NIK_Mmus         ---------ESLDQ--------------IPNNVAH-------------------ATEGKM
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ----------TPTA--------------IDNNDSD-------------------LTEDVI
DDB0229973_Ddis  QSA------SALLK--------------IHHQRNQ-------------------STGSAF
DDB0230010_Ddis  ---------LALEQNPNDFKALVKWGSLIYKNIKN-------------------QMGGKH
IfkA_Ddis        -RHQMGDIGSSVNK--------------IINSIDHTISHGGGVGVGIGSGNGLFSKSSSS
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ----------SLPP--------------IPERSSP-------------------AGHQEM
STE-Un_a_Smoe    ---------------------------AIPEEMVL-------------------LDSGNY
STE-Un_b_Smoe    ---------VSMEQDARRIG---TLGAIVFNNFYV-------------------EKEGFV


NIK_Hsap         ARVCW-KGKR--------------------------------------------------
NIK_Mmus         ARVCR-RGKR--------------------------------------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  NAVSKYKD----------------------------------------------------
DDB0229973_Ddis  SNTIY-NG----------------------------------------------------
DDB0230010_Ddis  VDVCL-M----------------------DWNE--------------------ELIPIP-
IfkA_Ddis        --SS-PMI-PYNFSFDSLNGFDPDIIFE---------------DSFQTPLKGSSSIDFEE
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ASIL-EKV----------------------------------------------------
STE-Un_a_Smoe    RTVDK-RG----------------------------------------------------
STE-Un_b_Smoe    GGVAV-RGFL------------DCL--VNSWKEAGHKVKFIFFISGMTL-----------


NIK_Hsap         ------------------------------------------------------------
NIK_Mmus         ------------------------------------------------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  ------------------------------------------------------------
DDB0230010_Ddis  ---------------------QNNNNHHNHNHHNNHTSGNFTG-----------------
IfkA_Ddis        MNNLTNSNNSNSTATTTTTTTTNNNNNNNTNNNNNNNSNNNNNNNNNNNNTNNNTNNNNN
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    ------------FECKSSG-----------------------------------------


NIK_Hsap         ------------------------------------------------------------
NIK_Mmus         ------------------------------------------------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  --------------------G---------------------------------------
DDB0229973_Ddis  --------------------E---------------------------------------
DDB0230010_Ddis  ---------------------NINSNTTLSNSFFETLNSFNLREPLFDVCGKYQSSLQLS
IfkA_Ddis        NNNNNNNNNNNNNNNNNNNNNNSNNNNN--------------------------------
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    --------------------K---------------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    ------------------------------------------------------------


NIK_Hsap         ------------------------------------------------------------
NIK_Mmus         ------------------------------------------------------------
COT_Mmus         --------------HLNVSEVIDIMENLYASEEPGVY-----------------------
COT_Hsap         --------------HLNVSDVIDIMENLYASEEPAVY-----------------------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  ------------------------------------------------------------
DDB0230010_Ddis  GGSNLLNIPFSTLLNYNLNEQLNILVNNLNNSSPSSSSSSIKTKNTTSTTTTTTTTKNL-
IfkA_Ddis        -----------------------------------------------------ISNNKIN
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    ------------------------------------------------------------


NIK_Hsap         --------------------------------------------------RSKARKK---
NIK_Mmus         --------------------------------------------------HGKARKK---
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  -------------------------------------------------TSSKSVKK---
DDB0229973_Ddis  -------------------------------------------------EKTRDTIS---
DDB0230010_Ddis  -----------------------------------------------------NDIS---
IfkA_Ddis        KINNNNNNKELIDNNNNNKDKENDLINDTIPKIKWKKGSCIERKSNYSVYRGVDEDTDRK
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    -------------------------------------------------ERIQEEDD---
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    -------------------------------------------------MFPSARL----


NIK_Hsap         ----------------------------------------------RKKKSSKSL-----
NIK_Mmus         ----------------------------------------------RRKKRSKSL-----
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ----------------------------------------------TRRKFAMNI-----
DDB0229973_Ddis  ----------------------------------------------Y----NERP-----
DDB0230010_Ddis  ----------------------------------------------NNIN-NSRV-----
IfkA_Ddis        LICKIVNLNIDDRSSSSLTSLSNSNNNNSNNNNNNNNNNNNNNNNNNNNNNNNNL-----
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    -----------------------------------------------------EE-----
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    -----------------------------------------------SKEEQSALSKLQV


NIK_Hsap         ------AHAGVAL-----------------------------------------------
NIK_Mmus         ------AQAGVAL-----------------------------------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ------ATDEVFN-----------------------------------------------
DDB0229973_Ddis  ------KRQTVGS-----------------------------------------------
DDB0230010_Ddis  -------LRSVSL-----------------------------------------------
IfkA_Ddis        ------SIDVVEL-----------------------------------------------
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------EPTSIRP-----------------------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    SSIKERRQGLAALVEFLLGGMHENGAENVIGQSVRGIVPSARDTAINWNTFHETGSDGVY


NIK_Hsap         -----------------------------------------------------AKPLP--
NIK_Mmus         -----------------------------------------------------AKPLP--
COT_Mmus         ---------------------------------------------------------EPS
COT_Hsap         ---------------------------------------------------------EPS
DDB0229972_Ddis  -----------------------------------------------------LPPME--
DDB0229973_Ddis  -----------------------------------------------------STFFP--
DDB0230010_Ddis  -----------------------------------------------------PPAPP--
IfkA_Ddis        -----------------------------------------------------KKRLI--
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    -----------------------------------------------------SRPTT--
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    ASSKCCGSFSVQNNGWLRLLEWLDRRFLERLLEEALLVVDSGGRGASKVVEAFLKVIE--


NIK_Hsap         -----------------------R------------------------------------
NIK_Mmus         -----------------------R------------------------------------
COT_Mmus         LMTMYPDSNQNEERSESLLRSGQE------------------------------------
COT_Hsap         LMTMCQDSNQNDERSKSLLLSGQE------------------------------------
DDB0229972_Ddis  -----------------------Q------------------------------------
DDB0229973_Ddis  -----------------------P------------------------------------
DDB0230010_Ddis  -----------------------P------------------------------------
IfkA_Ddis        -----------------------E------------------------------------
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    -----------------------L------------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    -----------------------VIPGEASSSIGAFLLTHLEDAVSSILDSVCRHSSAGK


NIK_Hsap         TPEQESCTIPVQEDESPL--GAPYVR----------------------------------
NIK_Mmus         TPEQESCTIPVQEDESPL--GNLYAR----------------------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  QQQQQHLQPPLSPNSASN--TNFGA-----------------------------------
DDB0229973_Ddis  PPSRATSTSSIQVNSDPQEIEQLTEEQYLEMLEKRRQVSLQILQTEKEYAF---------
DDB0230010_Ddis  PPTED--------PNSPW--SDPILW----------------------------------
IfkA_Ddis        KV---KMIQKEIESMKYL--GNPYI-------------------------IKYLGTNFQE
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    SP---HAPPPKEEKNTPL--TPGTV-----------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    NSDQEMFSIHVEGKEGQD--SSREVE----NLEKMVH-----------------------


NIK_Hsap         ------------------------------------------------------------
NIK_Mmus         ------------------------------------------------------------
COT_Mmus         ---------------------------------------------------VPW------
COT_Hsap         ---------------------------------------------------VPW------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  ------------------------------------------------------------
DDB0230010_Ddis  ------------------------------------------------------------
IfkA_Ddis        GQNTLYIFQEYNSTLTLQQKILSNGIGFEESQVKKFTYQLLLGLLYLHSQHIPHRDFKSH
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    ------------------------------------------------------------


NIK_Hsap         ------------------------------------------------------------
NIK_Mmus         ------------------------------------------------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  -------------------------YL---------------------------------
DDB0230010_Ddis  ------------------------------------------------------------
IfkA_Ddis        NIFFNQST----------SKMLLSNYG---------------------------------
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    -------------------------------------------------SANELGESTDL
STE-Un_b_Smoe    -------LSNMLSAIVHGSSIAAAVFADLIAGTAVDAVIDLIQVYYFEGSRGEVSPCGDL


NIK_Hsap         ------------------------------------------------------------
NIK_Mmus         ------------------------------------------------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  ------------------------------------------------------------
DDB0230010_Ddis  ------------------------------------------------------------
IfkA_Ddis        ------------------------------------------------------------
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    PL--------------------------------------------QSKQLTV----TEK
STE-Un_b_Smoe    PGEVLEQDRVMHSYPVVGAAPDASDEDHSATVAFCPFSSSGINAILQGQQVATFKSSCQS


NIK_Hsap         -------------------NTPQF--------------------------TKP-------
NIK_Mmus         -------------------NVSQF--------------------------TKP-------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ------------------AAT---------------------------------------
DDB0229973_Ddis  -----------------NIIVEEF--------------------------LQP-------
DDB0230010_Ddis  ------------------------------------------------------------
IfkA_Ddis        -----------------GRNIKIFDHFEKLNSLKNLNSWISSTNNSINNINNINNNNNNN
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    --------------------LRQY------------------------------------
STE-Un_a_Smoe    AGTHAGST---HKRLGH-CPVEGN--------------------------PKP-------
STE-Un_b_Smoe    SGFAKVLLKLVLKRVGAVSTVKGF--------------------------PLP-------


NIK_Hsap         -------------------------LKE--------------------------------
NIK_Mmus         -------------------------LGG--------------------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  -------------------------LKNESNLSNNPFISKAQVKQLFGDTEVILGSSKLL
DDB0230010_Ddis  ------------------------------------------------------------
IfkA_Ddis        NNNINTTTTQNQINNEIDRREDIINLG---------------------------------
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    -------------------------SKR--------------------------------
STE-Un_b_Smoe    -------------------------NGG--------------------------------


NIK_Hsap         ---------------PGLGQLCF--------------------KQLGE------------
NIK_Mmus         ---------------PGLGHLCF--------------------KKQDE------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  AEDLENVLLDGTSNPIGLGD-CF--------------------LKICDYFK--LYASYVK
DDB0230010_Ddis  ---------------MKWGD-CL--------------------FLLCTYLELPMYRATCE
IfkA_Ddis        --------------IVVLEM-LCGSDLANNQTVLIYLAQLNLLNN---------------
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    ---------------RKAA-----------------------------------------
STE-Un_b_Smoe    ---------------RSGGKKTS--------------------LKASR------------


NIK_Hsap         ------------------------------------------GLRPALPRSELHKLI---
NIK_Mmus         ------------------------------------------GLRPVLPRPELHKLI---
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  --------------------------------------------------------F---
DDB0229973_Ddis  NYYTSISVLNKLKEESHKFQAFIQ----EKEQILLDSNFTDLGALLVLPVSRIGQYT---
DDB0230010_Ddis  KYFKCIQILFKQQEKQHQQQQQQQQNQQDKEKFE--------------------------
IfkA_Ddis        ---------------------------------------QQQNQNFIQPPPLQYQLQ---
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    ------------------------------------------AFRLMLPRGGTKEVSSNS


NIK_Hsap         ------------------------------------------------------------
NIK_Mmus         ------------------------------------------------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  ------------------------------------------------------------
DDB0230010_Ddis  ------------------------------------------------------------
IfkA_Ddis        ------------------------------------------------------------
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    ----------------------------------EKFSEVSYKYSKDSFCGF--------
STE-Un_b_Smoe    TKASAVICHLLSAAAVMLTNRSSSLAQTRRKLVQEFKGP-RKLLLISSFVEELVRTVCDG


NIK_Hsap         SPLQC-------------------------------------------------------
NIK_Mmus         SPLQC-------------------------------------------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  SPTSI-------------------------------------------------------
DDB0229973_Ddis  SMINY-------------------------------------------------------
DDB0230010_Ddis  ------------------------KQNNYNIKLLAIVLRKWGITLSRYSRRM--------
IfkA_Ddis        QQYDL-------------------------------------------------------
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    SPEKAHEHIFQIIHVLDESDEHKSQGSRYPVLMLSEIQSRIKATLSDHKARVMENDGKQT


NIK_Hsap         ------------------------------------------------------------
NIK_Mmus         ------------------------------------------------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  ------------------------------------------------------------
DDB0230010_Ddis  ------------------------------------------------------------
IfkA_Ddis        ------------------------------------------------------------
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    EQMVSLWEVWVALGSLLQVLSSFACKWPEEGGALLVFQRCGAEVGAVLHLLSSSEGPASW


NIK_Hsap         ------------------------------------------------------------
NIK_Mmus         ------------------------------------------------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  ------------------------------------------------------------
DDB0230010_Ddis  ------------------------------------------------------------
IfkA_Ddis        ------------------------------------------------------------
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    GGGELLVMQNILRLFAICMQNSHCRQRELDNLLWNTLIDKNWEFIRRYSQWVVVDACHDC


NIK_Hsap         -----LN-----------------HVWKLH------------------------------
NIK_Mmus         -----LN-----------------HVWKLH------------------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  -----LS-----------------KNNKI-------------------------------
DDB0229973_Ddis  -----LF-----------------SLTPQSHPDY-EPFKKAVIKMKSTVDYVKEKIRDND
DDB0230010_Ddis  ------KSQFLMSEWTSDENIQVEELWKVL------------------------------
IfkA_Ddis        -----IK-----------------EIEQKTHPSSPISNNAKDFLSLCFTINGNGSTNDSL
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    -----------------------------NENPGHLPNHLKEYIE-----------KRAD
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    TWDLLEE-----------------SLWSVW------------------------------


NIK_Hsap         -----------HPQDGGPLPLPTH----------------------PFPYSRLPH-----
NIK_Mmus         -----------HPQATGPRPHPTH----------------------PFPYSGMPH-----
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  SQNKVRIIQNQM----------TG----------------------KFENLNLPH-----
DDB0230010_Ddis  -----------HSQSIQSLLISNK----------------------ISP-SLVTQ-----
IfkA_Ddis        EAGILLKHP-FLASNSNSTPPPSNFLNFTNNIKFLDQRSAATQALLSSPHSLIPQPIQTL
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    A--IVQEVVPETPTSVQALPRPTH----------------------DVPRAELPH-----
STE-Un_a_Smoe    ------------------DDHLVD----------------------GFYDAGRDH-----
STE-Un_b_Smoe    -----------EPLEFRDLSDPTG----------------------DLFSSWLPR-----


NIK_Hsap         ------------------------------------------------------P-----
NIK_Mmus         ------------------------------------------------------P-----
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  ------------------------------------------------------RRYVRE
DDB0230010_Ddis  ------------------------------------------------------------
IfkA_Ddis        IKSQTPNNNNDNNNLASSNELLSSSNGSNIDLRSTNSSIVSNPLATSSSLDNITP-----
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------------------------------------------------------P-----
STE-Un_a_Smoe    ------------------------------------------------------P-----
STE-Un_b_Smoe    ------------------------------------------------------W-----


NIK_Hsap         -----------------------------FPFHPLQPWKPHPLE----------------
NIK_Mmus         -----------------------------FPFYPLEPWKPYMLD----------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  GMLTESGKGSNSNQYYCFLFNDIFVLSTPI--------KKSNQF----------------
DDB0230010_Ddis  -------------------------------YHLATAYHRHAITLNQFGCQSKEEIYGLI
IfkA_Ddis        -----------------------------PPSRPISP-KPSPLN----------------
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    -----------------------------TPPIVHQT-S---------------------
STE-Un_a_Smoe    -------------------------------FLPLEALENEQ-F----------------
STE-Un_b_Smoe    -----------------------------LPSMQCEEIPVINLV----------------


NIK_Hsap         -----------------SF---------------LGKLACVDS-----------------
NIK_Mmus         -----------------SA--------------VLDKLAGVSG-----------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  -----------------SF---------------KKKISLSEA-----------------
DDB0230010_Ddis  TNSCKIYYETLLESLSDTF---------------LQQLQLQQQ-----------------
IfkA_Ddis        -----------------KR---------------NQKLQTSQQ-----------------
CC1G_01579_Ccin  --------------------------VEK-------------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    -----------------SFNRREVILVDRTKDEDLDAMASSAKQ----------------
STE-Un_b_Smoe    -----------------SFLRLTIGLIQRKADREKNLLLPGKTRILLEFLMNPVTGLLMK


NIK_Hsap         ---------QK-----PLPD-PHLSKLACVDS----------------------------
NIK_Mmus         ---------QR-----PLPGPPHLSQLAHGDS----------------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  ---------EVTMISDPEDRPIFQISIQNIDS----------------------------
DDB0230010_Ddis  ---------QQ-----P-------------------------------------------
IfkA_Ddis        ---------KP-----PL-SPPQTPLKQIPQS----------------------------
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    ----------L-----LVSLGPGGATFEHGSSDLYNVAMLALFVSDCLGGSDKTLNVKIM
STE-Un_b_Smoe    LLKGDGFSKKK-----MIPQ------------KDYEAAFFHLKHVREDLRNLIPF--CT-


NIK_Hsap         ---------PKPLPGPHLEPSCLSRGAHEKFSVEEYLVHALQGSVSSGQ-----------
NIK_Mmus         ---------QKPLPGPHLESSCPSRGALEKVPVEEYLVHALQGSVSSGQ-----------
COT_Mmus         -----------------------------------------LSSVRYGT-----------
COT_Hsap         -----------------------------------------LSSVRYGT-----------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  ---------QQDN-SP--------------------------------------------
DDB0230010_Ddis  ----------------------------------------WHDIEYYNNNEIFNDQFKSK
IfkA_Ddis        ---------PQSPPQQ--------------------------------------------
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    RRTALGSTSSMPFVCSCCATG---------------------------------------
STE-Un_b_Smoe    QRQGISGRVPHPVPASPQESTNRQQRG-----TERFGGNAVEGGQVSGP-----------


NIK_Hsap         ---------------------------AH---SLTSLAKTWAA---------------RG
NIK_Mmus         ---------------------------AH---SLASLAKTWSS---------------GS
COT_Mmus         ---------------------------VE---DLLAFANHVSN---------------MT
COT_Hsap         ---------------------------VE---DLLAFANHISN---------------TA
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  ------------------------------------------------------------
DDB0230010_Ddis  SLENWGRALDVQLSTKLNDEEETIEKEEE---DLNSVDEYLTT---------------FS
IfkA_Ddis        ------------------------------------------------------------
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    ---------------------------ASVSYNLSYLAATNLEIASLQLLASIFGLSFHG


NIK_Hsap         SR-----SREPSPKTEDNEGV---------------------------------------
NIK_Mmus         AK-----LQRLGPETEDNEGV---------------------------------------
COT_Mmus         KH-----FY---GRRPQECGI---------------------------------------
COT_Hsap         KH-----FY---GQRPQESGI---------------------------------------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  ------------------------------------------------------------
DDB0230010_Ddis  K--------S--------------------------------------------------
IfkA_Ddis        ------------------------------------------------------------
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    QRHRTTLSQSLLGRTAARNPFLGKAYAYPFLDFHFLRLIHLYYVNLLQGRKLKLAEPTLE


NIK_Hsap         ------------------------------------------------------------
NIK_Mmus         ------------------------------------------------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  ------------------------------------------------------------
DDB0230010_Ddis  ------------------------------------------------------------
IfkA_Ddis        ------------------------------------------------------------
CC1G_01579_Ccin  -----------------------VRDK--ETG----------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    -----------PSDSGASFSG--ALPSMRTLSDEAIRHVK--------------------
STE-Un_b_Smoe    KVSENSCTLAWCSDNEAPCSEAEVRDE--QLSLECAVHVQVLLALAQNQSDDVTLRFKQL


NIK_Hsap         ------------------------------------------------------------
NIK_Mmus         ------------------------------------------------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  ------------------------------------------------------------
DDB0230010_Ddis  ------------------------------------------------------------
IfkA_Ddis        ------------------------------------------------------------
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    --------------------LKRNSNV---------------------------------
STE-Un_b_Smoe    RVMDFLVHQIALEYEASQVATPRDVVRINKALASQLRSSASSFRTKNVGDPSARTSETSH


NIK_Hsap         ------------------------------------------------------------
NIK_Mmus         ------------------------------------------------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  ------------------------------------------------------------
DDB0230010_Ddis  ------------------VLKGV----TPSLEGVVSLCLNSKQALQYKA-----------
IfkA_Ddis        ------------------------------------------------------------
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    -------------VPLGSLPYGVCRHRAILMKVCSKHCV------LY-------------
STE-Un_b_Smoe    PSMESSVSSDVTTPSVAGLKKGLCLL-SPELEGSNKSCL------VHKKLEKSLSKDMPK


NIK_Hsap         ------------------------------------------------------------
NIK_Mmus         ------------------------------------------------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  ------------------------------------------------------------
DDB0230010_Ddis  INSVSVLCRSSEIVKSPIYNELMDQMTKVESFVSKRDDAESLLSQQKTLKSMPPKLQAYV
IfkA_Ddis        ------------------------------------------------------------
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    LELGFLSARTLSAVQSSSCESY--------------------------LLSRPFT-----


NIK_Hsap         ------------------------------------------------------------
NIK_Mmus         ------------------------------------------------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  ------------------------------------------------------------
DDB0230010_Ddis  RMSGLGEEEIMRNFEIAWNSIYFLTKDTIPNQPIPPNYYRSNKKNKLK------------
IfkA_Ddis        ------------------------------------------------------------
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    -----GRHEFL----QKWQEVM------KPAVPMHPVHEQASEKVAFPVTVDENNLAEDI


NIK_Hsap         ------------------------------------------------------------
NIK_Mmus         ------------------------------------------------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  ------NMLSLNGIQNAINNMTNNDSKS------------------K-NNNNNNSNGNN-
DDB0230010_Ddis  --------------QRQLNDSNNQDEKEEPEEIKPPLLPSIHRTNQLNNNNNNNNNINNN
IfkA_Ddis        ------N-----------------------------------------------------
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    EGDFAPEKVVYTGKFFDLNEEVERELAE------------------E--DGQDRPNSDN-


NIK_Hsap         ------------------------------------------------------------
NIK_Mmus         ------------------------------------------------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  --NNNNINSNSNSNNNS---------------------------------VIDIKSSGVL
DDB0230010_Ddis  NINNNNINNNKNGNSGGETPSPSSSFVITPFTSNSQSKFNTQRQFLSNSTLFNLSSSGIF
IfkA_Ddis        ------------------------------------------------------------
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    --DSSDSESLTHS---------------------------------------EDDSIGSL


NIK_Hsap         ------------------------------------------------------------
NIK_Mmus         ------------------------------------------------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  INNGGGS---GFISNNNGITNVNSNNNNNNNINSNNNINGNNNNGNNSVNYSNGEDNN--
DDB0230010_Ddis  TNNN---------NNNNGGSTITT-----------------TTTNNISPT----------
IfkA_Ddis        --------------FNTPPTTTT-------------------------------------
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    ANEGGKASFRPFIPKLNLPRSARKGDQENSAEEAKPEIQ-VSKPGNKSPGVSLAGDGQTS


NIK_Hsap         ------------------------------------------------------------
NIK_Mmus         ------------------------------------------------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ----------------------------------------------------I-------
DDB0229973_Ddis  -DRECFTF-------------------------IADSNRDREDWIQAIH-ANIISSK---
DDB0230010_Ddis  ---------------------------------------KTNGWTLTLP-SKAP-TRRAT
IfkA_Ddis        ------------------------------------TTTTPTATPTTPTMTPL-------
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    -------------------------------------------------QDIV-------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    GGSCKLTTPYEMERSQRRLYRNSSLHLFLLELYI---------------TLML-------


NIK_Hsap         ------------------------------------------------------------
NIK_Mmus         ------------------------------------------------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ----------TSQ-----------------------------------------------
DDB0229973_Ddis  ----------KRNE----------------------------------------------
DDB0230010_Ddis  VSLININDLINQQ--------QQNQINSVSTLSQNNIILNNNNNLDNKPISKYIPN----
IfkA_Ddis        ----------TPIQ-------KQ-------------------------------------
CC1G_01579_Ccin  -----------------------------AIVVRKSLSYEP-------------------
AqueK223_Aque    ----------YPIN-------EK---------------YL--------------------
STE-Un_a_Smoe    ----------SRLV-------LQYLCDRSSPVIPCELVRGY---------LDYMPHAWNV
STE-Un_b_Smoe    ----------TPQGTLDQRYSDRFQTEKQKLNAPFFLFYRI-------------------


NIK_Hsap         -----------LLTEKLKPVDYE-YREEV-------------------------------
NIK_Mmus         -----------LLTEKLKPVDYE-YREEV-------------------------------
COT_Mmus         -----------LLNMVISPQNGR-YQIDS-------------------------------
COT_Hsap         -----------LLNMVITPQNGR-YQIDS-------------------------------
DDB0229972_Ddis  -------------------QTSSTSISPL-------------------------------
DDB0229973_Ddis  ---------------TRKPEDIE-KG-GI-------------------------------
DDB0230010_Ddis  ----------SIIRTTVNPPLLS-RCDE--------------------------------
IfkA_Ddis        -----------------QQIDYDMFRYHS-------------------------------
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ---------------HLGP-DGNYYEIRD-------------------------------
STE-Un_a_Smoe    VLVCRGGVNVRMLVDACRPLDIR-LESDPEYFCRFVSRFSIFVLFKQSFYFLSRYI-PTR
STE-Un_b_Smoe    -----------------------------------------------LFYLLAVLLWKTV


NIK_Hsap         --H-----WA-------------------------------------------THQLRLG
NIK_Mmus         --H-----WM-------------------------------------------THQPRVG
COT_Mmus         --DVLLVPWKLTY--------------------------------------RNIGSGFVP
COT_Hsap         --DVLLIPWKLTY--------------------------------------RNIGSDFIP
DDB0229972_Ddis  --K-----PSP----------------------------------------LSFSSGILP
DDB0229973_Ddis  --D-----FSVS---------------------------------------DIKLCEQIG
DDB0230010_Ddis  ------------TI-FSSGTPL----------------------------PLFRDKIKLG
IfkA_Ddis        --R-----YRT----------------------------------------DFEEIEMIG
CC1G_01579_Ccin  -----------------------------------------------------------G
AqueK223_Aque    ----------Y----------------------------------------DRVDNEILG
STE-Un_a_Smoe    RIH-----VQPRVVELGSGTFL----------------------------PLFYE--EIG
STE-Un_b_Smoe    QLD-----LHPDLNHVANSYLLPCLTERMKAFHHSAFRILRLSWRGLFNSSLYRNRIRIA


NIK_Hsap         R-----------GSFG-EVHRMEDKQ-TGFQC-AVKK--VRLE-------------VF--
NIK_Mmus         R-----------GSFG-EVHRMKDKQ-TGFQC-AVKK--VRLE-------------VF--
COT_Mmus         R-----------GAFG-KVYLAQDMK-TKKRM-ACKL--IPID-------------QF--
COT_Hsap         R-----------GAFG-KVYLAQDIK-TKKRM-ACKL--IPVD-------------QF--
DDB0229972_Ddis  PSSRIYESPPTLGKYD-KVILVILSQ-QYLQN-QVNI--FPIKLIDRERINLIH-QNI--
DDB0229973_Ddis  S-----------GGSGCTVHRCT--V-DGFTC-AVKV--LKLK--NTS---PFLVEQF--
DDB0230010_Ddis  T-----------GAFG-NVFYAIRKS-DSSPV-AIKV--LMER--T-------KKDSP--
IfkA_Ddis        K-----------GGFG-VVVKSRNKL-DCRYY-AIKK--IKTK--GYTDSNQEPLTNK--
CC1G_01579_Ccin  N-----------AASGP---------------------------------------GD--
AqueK223_Aque    E-----------GGFG-TVYACSDRY-YQTMF-AIKC--NKHN--SEE-----KVRNM--
STE-Un_a_Smoe    F-----------GASGAEVRKCSIRQLDS----AVVK--ESSD-------------GG--
STE-Un_b_Smoe    H-----------GAFAQ-IYK-ATVNEEDGPRLVVLKTVELPK-------------GPYE
                             .

NIK_Hsap         ------RAEELMAC-AG-LT-SPRIVPLYGAVR---------------------------
NIK_Mmus         ------RVEELVAC-AG-LS-SPRIVPLYGAVR---------------------------
COT_Mmus         ------KPSDVEIQ-AC-FR-HENIAELYGAVL---------------------------
COT_Hsap         ------KPSDVEIQ-AC-FR-HENIAELYGAVL---------------------------
DDB0229972_Ddis  ------LSNEFQLL-KSL-K-HSGIVNYIGMI----------------------------
DDB0229973_Ddis  -------ISEITIM-VK-LS-HQNIAKYLGHR----------------------------
DDB0230010_Ddis  ------IIPELYIH-SA-CN-HSNIVTYIESYL---------------------------
IfkA_Ddis        ------LLREVTTL-SRL-H-HQFVVRYYQAWIEKSCDSFQSLEEGNEDLSGDLETDASE
CC1G_01579_Ccin  ------VIDELKRFT-H-LR-HTNIIIIHGWYLSR-------------------------
AqueK223_Aque    ------NL-ECRVL-DHIGH-HTHITQLFGAMIDKNVSA---------------------
STE-Un_a_Smoe    ------WLSELRIHCSI-GE-HPNVVAFYGHQLSFESAAS--NG----------------
STE-Un_b_Smoe    PCKFFDVYSEVQILE-K-FLGEPKISQLLDYGLES-------------------------
                          :              :

NIK_Hsap         ------------------------------------------------------------
NIK_Mmus         ------------------------------------------------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  ------------------------------------------------------------
DDB0230010_Ddis  ------------------------------------------------------------
IfkA_Ddis        DWFMQSSINSRSIISRDSYSGLSTSNSNVGGVNNTAGGGDSVSNANSNKSMIVGNSNKKL
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    ------------------------------------------------------------


NIK_Hsap         ------------------------------------------------------------
NIK_Mmus         ------------------------------------------------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  ------------------------------------------------------------
DDB0230010_Ddis  ------------------------------------------------------------
IfkA_Ddis        TLSSSNTSSSSSLLSNNKSKILNTSKSTSTNTSTSTSTSNTNKNKKISKKKKSKLSPLMK
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    ------------------------------------------------------------


NIK_Hsap         ------------------------------------------------------------
NIK_Mmus         ------------------------------------------------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  ------------------------------------------------------------
DDB0230010_Ddis  ------------------------------------------------------------
IfkA_Ddis        PKNKKNKNNGESEQSSSDSENGENGMKSRIIENASDSYSDDDNNNNNNNDNNNNYHSDNE
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    ------------------------------------------------------------


NIK_Hsap         ------------------------------------------------------------
NIK_Mmus         ------------------------------------------------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  ------------------------------------------------------------
DDB0230010_Ddis  ------------------------------------------------------------
IfkA_Ddis        SDSFSGSISMSDGNGSGYEATDDEDIINNSGSFDENENDDDDEEDDDDEYDEEDDDYETF
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    ------------------------------------------------------------


NIK_Hsap         --------------------------EGPWVNIFMELLEGGSLGQLV------KE-----
NIK_Mmus         --------------------------EGPWVNIFMELLEGGSLGQLI------KQ-----
COT_Mmus         --------------------------WGDTVHLFMEAGEGGSVLEKL------ES-----
COT_Hsap         --------------------------WGETVHLFMEAGEGGSVLEKL------ES-----
DDB0229972_Ddis  -------------------------NDNTGFGIVQEFYENGSLSDIY------N------
DDB0229973_Ddis  -------------------------LSGNQLWLFMEFYPHS-LKDVI------TK-----
DDB0230010_Ddis  --------------------------CKGHVWIILEYCDGGTVRDLL------QATCTPG
IfkA_Ddis        DFQDKSRVVSNNSKLSTSSSRKKPPKETHTLYIQMEYCSKKTLKTLI------D------
CC1G_01579_Ccin  ---------------------------WGLPRVLMEYCEGGSLESIN------ERI----
AqueK223_Aque    -----------------------CVYEGQKFKMLMELATNGSLDELL------FDPDT--
STE-Un_a_Smoe    ------------------AN---KKLDAPQLVIFMEYVKGGSLDNVI------TRF----
STE-Un_b_Smoe    ----------------------------ETFVLVLKHYKCSLRAWRLNQGGLHSHK----
                                                 :  :

NIK_Hsap         ----QG--CLPEDRALYYLGQALEGLEYLHSRR--ILHGDVKADNVLLSSDGS-------
NIK_Mmus         ----MG--CLPEDRALYYLGQALEGLEYLHTRR--ILHGDVKADNVLLSSDGS-------
COT_Mmus         ----CG--PMREFEIIWVTKHILKGLDFLHSKK--VIHHDIKPSNIVFMST---------
COT_Hsap         ----CG--PMREFEIIWVTKHVLKGLDFLHSKK--VIHHDIKPSNIVFMST---------
DDB0229972_Ddis  ---RSG--AFQESLVAKYTLQILEALGYIHSQG--IVHRNLKSNNVLLAKGG--------
DDB0229973_Ddis  ---RTS--PFPATEVIWMALEIAKGLEFLHTQKNPIIHRDLKPGNIMCSLDDKG------
DDB0230010_Ddis  NPNNLQ--LFEETLIAYIITELLEGLVYLRSKG--IIHRDLKSRNILLTRKG--------
IfkA_Ddis        ---NVG--GIAEEEAFRLLRQIVEGLNHIHSQQ--IIHRDLKPANIFIDNEQ--------
CC1G_01579_Ccin  --IEKNVT-VEERIAGQVAEGILQGLSYLFSQD--LIHNSLEPANILFSKGGL-------
AqueK223_Aque    --NEPS--GLPFNQSLFYLQQILYAVHFLHQRA--ILHLDLKCANVLLFNEGR-------
STE-Un_a_Smoe    --SKDGCLYTPPRLAINIAESVAQGLVWLHSRG--IIHRDIKSSNILVDLDSPD------
STE-Un_b_Smoe    --SGKSFV-DRLPLYLEVYAAVLDAVKVLEAHN--VVHYDLKCDNVLLEPVDSVISEEEF
                                         .:  :  :   ::* .::  *:.

NIK_Hsap         -----------------HAALCDFGHAV-CLQPDGLGKSLL-------------------
NIK_Mmus         -----------------RAALCDFGHAL-CLQPDGLGKSLL-------------------
COT_Mmus         -----------------KAVLVDFGLSV-KMTEDV-------------------------
COT_Hsap         -----------------KAVLVDFGLSV-QMTEDV-------------------------
DDB0229972_Ddis  -----------------KVKISDFAIGI-RSSAI--------------------------
DDB0229973_Ddis  --------------RVCSIRVCDFDTSK-ELGN---------------------------
DDB0230010_Ddis  -----------------KVKIADFGLAT-TCSL---------------------------
IfkA_Ddis        -----------------NVKIGDFGLAT-SGAPVSKSDDLNSSTSNTANNINLSSSTNST
CC1G_01579_Ccin  ------------------VKLSGHPWAE-IVHQGA-------------------------
AqueK223_Aque    -----------------TVKLTDFGSAV-RLDESG-------------------------
STE-Un_a_Smoe    --------------NRPVVKICDFDSAV-PVGSSSIHTCYL-------------------
STE-Un_b_Smoe    WDPTWPPSEENSHPLPFRVCLADFGQSKASVFQGG-------------------------
                                     : ..  .

NIK_Hsap         ---------------TGDYIPGTETHMAPEVVLGRS-----------CDAKVDVWSSCCM
NIK_Mmus         ---------------TGDYIPGTETHMAPEVVMGKP-----------CDAKVDIWSSCCM
COT_Mmus         --------------YLPKDLRGTEIYMSPEVILCR-----------GHSTKADIYSLGAT
COT_Hsap         --------------YFPKDLRGTEIYMSPEVILCR-----------GHSTKADIYSLGAT
DDB0229972_Ddis  ------------EPSIRFSLNGYPFWTSPEVLSM-----K------PFNHKVDSWSIGCL
DDB0229973_Ddis  ------------GVTLKTC-IGTPCYMAAEVLNVADGGNS------GYSLKADIWSFAML
DDB0230010_Ddis  ------------GRGRTR-MCGTMGRIAPEVIRRE-----------PYDTQSDIYSLGCL
IfkA_Ddis        AQQTPMWDLNDENLSMTGGV-GTPFYCCPEILEKN---TK------HYGTKVDMYSLGII
CC1G_01579_Ccin  ------------------HTSRRLYYMSPEQIQGLAT-S---------RGPSDIWSAGVV
AqueK223_Aque    ------------GCHIQSNKGLTPYFSAPEAIRC-----E------YVSFSADIWSVLCC
STE-Un_a_Smoe    ---------AHHGLPLTDVCVGTPRWIAPEVLGAMYT-RQ------QYGLEADMWSFGCF
STE-Un_b_Smoe    -------------ECTV-RNRGTEYVKSPEMLKLLRT-GGDASLDTCVGKAVDVWGLGCL
                                            ..* :                    * :.

NIK_Hsap         MLHMLNGCHPWTQ-----FFR-G--PLCLKI----------------AS-EPPPVREI--
NIK_Mmus         MLHMLNGCHPWTQ-----YFR-G--PLCLKI----------------AS-EPPPIREI--
COT_Mmus         LIHMQTGTPPWVK-----RYPRSAYPSYLYII---------------HK-QAPPLEDI--
COT_Hsap         LIHMQTGTPPWVK-----RYPRSAYPSYLYII---------------HK-QAPPLEDI--
DDB0229972_Ddis  IMELIVGHPPFSH-----LGPM---EALIEII---------------NP-STTILP----
DDB0229973_Ddis  CFEIISLLPPYHQ-----FQ--HLQ-SIEMII---------------NG-TCPPLPT---
DDB0230010_Ddis  IIEMAEGTVPYGK-----DS--SLKALFYTAI---------------HQ-YKLPNPK---
IfkA_Ddis        FFEMCFQFQT--------QMERSNILRDLRDN---------------L-KFPPGFE----
CC1G_01579_Ccin  LLEFVQKEFPWGS-----DL--SPVEIMMNIV---------------HG-EPPTLADK--
AqueK223_Aque    LVEMITGHLPWCY-----NGLRDPHNIIMLAG---------------HYCDAEPLKYF--
STE-Un_a_Smoe    ISELLTLNVPYAG-----IGDNEIHNHIKVSVVVTILSSPSHALVGQAG-ERPSLTWKLD
STE-Un_b_Smoe    LYELLAAEYLLYDEDWMRFFIRVTTNSEELIT---------------NE-KAEK------
                   .:

NIK_Hsap         -------PP---SCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNRALQQVGGLKSPWRGE
NIK_Mmus         -------PP---SCAPLTAQAIQEGLRKEPVHRASAMELRRKVGKALQEVGGLKSPWKGE
COT_Mmus         -------AG---DCSPGMRELIEAALERNPNHRPKAADLLKHEAL-------------NP
COT_Hsap         -------AD---DCSPGMRELIEASLERNPNHRPRAADLLKHEAL-------------NP
DDB0229972_Ddis  NCLDE--N-EQSLFSLELNQFLELCFKKEPSDRASVHDLLRHPWL-------------SM
DDB0229973_Ddis  ----D--L-IQPKLLQPLIELLVTCIDLNPNHRPNASQLVQKLT----------------
DDB0230010_Ddis  ------------KYTKEFVDFLYLCLNPDPFKRPTPEMLLHHTFL-------------SG
IfkA_Ddis        ------------STKPDQTQIIRSLLSRDPTQRPSTKQLLESGLL-------------PS
CC1G_01579_Ccin  -------TTDDAVWSNDLKDFLKQMLVNAPSGRKTAMELLEHSWI---------------
AqueK223_Aque    RCLVP--E-GIETEDPRILELFEKVFKRNPKDRPTALKLLEHELI-------------KD
STE-Un_a_Smoe    EIVLEPAVGGDKDCLDALIRLYESCTELDPGKRPTAQEALSSLQ----------------
STE-Un_b_Smoe    -------VG----NFGPVVEFIRFVLVRDPCRRPTLDEVMIHLRQLQ-------------
                                              *  *

NIK_Hsap         YKEPRHPPPN-QANYH--------------------------------------------
NIK_Mmus         YKEPRPPPQD-QATCH--------------------------------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  FNDSSSSSSSSSSQAHPTVQSNNLNGNVNSRTHGEFYSLDFLSQFEQNEKEISKILSSGD
DDB0229973_Ddis  ------------------------------------------------------------
DDB0230010_Ddis  ------------------------------------------------------------
IfkA_Ddis        KMEDDILKEAIKTIAN--------------------------------------------
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    AHEYEKEFD---------------------------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    ------------------------------------------------------------


NIK_Hsap         ------------------------------------------------------------
NIK_Mmus         ------------------------------------------------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  QLDSTSNQIDLKKFQFKHYNKKQQQQYNYNYNNYNNNNNNNNNTNDNDNECGEQTEEINL
DDB0229973_Ddis  ------------------------------------------------------------
DDB0230010_Ddis  ------------------------------------------------------------
IfkA_Ddis        -----------------------------------------------------P------
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    -----------------------------------------------------QYEDIDG
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    ------------------------------------------------------------


NIK_Hsap         QTLHAQPR-------------------------------ELSPRAP-GPRPAEE------
NIK_Mmus         QTLPTPPR-------------------------------ENPPAKA--------------
COT_Mmus         ------PR-------------------------------EDQPRCQ-SLDSAL-------
COT_Hsap         ------PR-------------------------------EDQPRCQ-SLDSAL-------
DDB0229972_Ddis  SSL-SKDEQIERLKAIIDQNETMANNLKYTMQEVLQEQTKYYEICE-SMKSKTLEI----
DDB0229973_Ddis  ------------------------------------------------------------
DDB0230010_Ddis  ------AD-------------------------------RG--------KSILLGRFKNQ
IfkA_Ddis        --------------------------------------------T-ISLFSYLMEKLF-C
CC1G_01579_Ccin  ----KSVI-------------------------------AQ-------------------
AqueK223_Aque    EVL-APPE-------------------------------AATPTSNDKVESNASGGSK-K
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    ESL-GRPK-------------------------------TK-------------------


NIK_Hsap         -TTGRAPK--------------------------------------LQPPLPPEPPEPNK
NIK_Mmus         -NTDGAPE--------------------------------------PQPPLPPEPPEPSK
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  ------------------------------------------------------------
DDB0230010_Ddis  D-----------------------------------------------------------
IfkA_Ddis        LSNDEHIMSRYLYTSNPSLTPMHLICREKTFSRLEKIFLNHGSIRIDTPTLFPKNPTNST
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    SSRASV--------------------------DSG--------------MDTERSSSNSS
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    ------------------------------------------------------------


NIK_Hsap         SP-PLTLS--KEESGMWEPLPLS-------------------------------------
NIK_Mmus         AP-ALNLS--KEESGTWEPLPLS-------------------------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ------LN--QNKTGARISAHSNSLL----------------------------------
DDB0229973_Ddis  --------KM--------------------------------------------------
DDB0230010_Ddis  ------------------------------------------------------------
IfkA_Ddis        HPGAANVAKFLDESGTVVYLPYDLTIPWARHVVIHNIQQAKRYTFSKVYRRSQPGFSPKE
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    SPGSA--TEL--------------------------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    ------------------------------------------------------------


NIK_Hsap         ------------------------------------------------------------
NIK_Mmus         ------------------------------------------------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  ------------------------------------------------------------
DDB0230010_Ddis  ------------------------------------------------------------
IfkA_Ddis        LYECDFDIIGPSKSRHISDAETLRIIIEIMEEFKDELFGNNSGSNSGSGSGGSINYKIRI
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    ------------------------------------------------------------


NIK_Hsap         ------------------------------------------------------------
NIK_Mmus         ------------------------------------------------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  ------------------------------------------------------------
DDB0230010_Ddis  ------------------------------------------------------------
IfkA_Ddis        NHYGLLDSILSECGVEKRFFTVVYQTVAQLHWRLNWAQVAQSLKEHGLSASIVSNISTYF
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    ------------------------------------------------------------


NIK_Hsap         ------------------------------------------------------------
NIK_Mmus         ------------------------------------------------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  ------------------------------------------------------------
DDB0230010_Ddis  ------------------------------------------------------------
IfkA_Ddis        RQRGELAQCVTQLESLLANHKEATTGISDLKILVRNLQMINIIPRFLLDLSLIHNHQYYE
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    ------------------------------------------------------------


NIK_Hsap         ---------------------------------SLEP-----------------------
NIK_Mmus         ---------------------------------SLDP-----------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  ------------------------------------------------------------
DDB0230010_Ddis  ------------------------------------------------------------
IfkA_Ddis        GLVFQAYIERPTLSNPSRTEIIMSGGRYDKLIKSLHPNPSLSNNIVSGVGVTLACEKIVN
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    ------------------------------------------------------------


NIK_Hsap         --------------------------APARNPSSPERKATVPEQELQQLEIELFL-----
NIK_Mmus         --------------------------ATAKGPSFPDRRATLPELELQQLEIELFL-----
COT_Mmus         ----------------------------------FERKRLLSRKELQLPE---NI-----
COT_Hsap         ----------------------------------LERKRLLSRKELELPE---NI-----
DDB0229972_Ddis  -------------------------KRTNQMANDLGRKYEILQSNIKRLEDYLITKDDCA
DDB0229973_Ddis  ------------------------------------------------------------
DDB0230010_Ddis  ------------------------------------------------------------
IfkA_Ddis        SVLNYRQHLLNNCFNTTYTRRNKDPPNSNNNPNNNNLNNNVSIFTKFQSHIEVFV-----
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    ------------------------------------------------------------


NIK_Hsap         --------------NSLSQPF---------------------------------------
NIK_Mmus         --------------NSLSQPF---------------------------------------
COT_Mmus         --------------ADSSCTG---------------------------------------
COT_Hsap         --------------ADSSCTG---------------------------------------
DDB0229972_Ddis  KKLANVVYRNKISFDSLLNPTLAANLLYQIGSKTWKKGQEKRAFATLKDNFLFFFKNEKS
DDB0229973_Ddis  ------------------------------------------------------------
DDB0230010_Ddis  ------------------------------------------------------------
IfkA_Ddis        --------------CSL-------------------------------------------
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    ------------------------------------------------------------


NIK_Hsap         ------SLEEQEQILSCLSIDSLS----LSDDSE----------KNP-------------
NIK_Mmus         ------SLEEQEQILSCLSIDSLS----LSDDSE----------KNP-------------
COT_Mmus         ------STEESEV-----------------------------------------------
COT_Hsap         ------STEESEM-----------------------------------------------
DDB0229972_Ddis  SYPIDVIYLNDKRNISITSI---QDSKKKAYIICIGTTIHDQNNLDPSNNNESVNLSTSP
DDB0229973_Ddis  ------------------------------------------------------------
DDB0230010_Ddis  ------------------------------------------------------------
IfkA_Ddis        ------------------------------------------------------------
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    ------------------------------------------------------------


NIK_Hsap         ------------------------------------------------------------
NIK_Mmus         ------------------------------------------------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  GSLVNSNSNPSISNSLNNNNNNNNNNNNNNNGNPNVIITTNNNCNSNSNGNNIATPPISI
DDB0229973_Ddis  ------------------------------------------------------------
DDB0230010_Ddis  ------------------------------------------------------------
IfkA_Ddis        ------------------------------------------------------------
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    ------------------------------------------------------------


NIK_Hsap         -----------------------------------------SKASQSSRDT---------
NIK_Mmus         -----------------------------------------SKASQSSRDT---------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  PNGKEVKEGKEIKEIKEPKEKDKDKEKDKDKEKDKDKEKDKDKEKEKDKDKENNNNNNSN
DDB0229973_Ddis  ------------------------------------------------------------
DDB0230010_Ddis  -----------------------------------------------TR-----------
IfkA_Ddis        ------------------------------------------------------------
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    ------------------------------------------------------------


NIK_Hsap         ------------------------------------------------------------
NIK_Mmus         ------------------------------------------------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  NNNNNGNNYNSSETIWCLLAFDNSKNMENWYGVLDSVVPWYDKRAYEISKPMLPIENKKH
DDB0229973_Ddis  ------------------------------------------------------------
DDB0230010_Ddis  ------------------------------------------------------------
IfkA_Ddis        -----------------GSSLLGEKLQVASQLWSAGIKADYSQTDYYSSEDIYSNCRENG
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ------------------------------------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    ------------------------------------------------------------


NIK_Hsap         ------------------------------------------------------------
NIK_Mmus         ------------------------------------------------------------
COT_Mmus         -----LRRQRSLYI----------------------------------------------
COT_Hsap         -----LKRQRSLYI----------------------------------------------
DDB0229972_Ddis  QKQKSLDSTNKQSPGS--------------------------------------------
DDB0229973_Ddis  ------------------------------------------------------------
DDB0230010_Ddis  ------------------------------------------------------------
IfkA_Ddis        IPWVVILREKAFQIGKLKVKQIETRQERTVARKDLVDFFLKSRKHNVDSKNIIQNTSSSD
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    -----IDSKASFSIGTLPVP----------------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    ------------------------------------------------------------


NIK_Hsap         ------------------------------------------------------------
NIK_Mmus         ------------------------------------------------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ------------------------------------------------------------
DDB0229973_Ddis  ------------------------------------------------------------
DDB0230010_Ddis  ------------------------------------------------------------
IfkA_Ddis        LSNLIGGINNSGSGGSGGSGGGSSMSSGGGGGGNSNIGGSDHHHHGHHSNQSTSSSGNSN
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ----GG------------------------------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    ------------------------------------------------------------


NIK_Hsap         -----------------------LSSGVHSWSSQAEARSSS----------------WNM
NIK_Mmus         -----------------------LSSGVHSWNSQAEARTCS----------------CST
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  ---------------------LGGAGGDVS----------WKKESGGIKFQGVVGVRLDD
DDB0229973_Ddis  ------------------------------------------------------------
DDB0230010_Ddis  ------------------------------------------------------------
IfkA_Ddis        NSNTQQTSPIQHHVHFSNTKSIIGSSGIISNATFSGGSSSS-----------------SN
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    ----------------------------------------------------------AS
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    ------------------------------------------------------------


NIK_Hsap         VLARGRPTDTPS---YFNGV----------------------------------------
NIK_Mmus         ALARGRPTDIPS---YFNGV----------------------------------------
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  LMTRESPTAELP---YFLSKMLKFLEKNVDEEGILRLSGSSTEILEMKQQLQRGESIDYT
DDB0229973_Ddis  ------------------------------------------------------------
DDB0230010_Ddis  ------------------------------------------------------------
IfkA_Ddis        IIHFDEPTDSFSTQIVYQGVE-EI------------------------------------
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    DC-PPPPHPP--------------------------------------------------
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    ------------------------------------------------------------


NIK_Hsap         ---------------KVQIQSLNGEHLHIR------------------------------
NIK_Mmus         ---------------KVQIQSLNGEHLHIR------------------------------
COT_Mmus         --D---------------------------------------------------------
COT_Hsap         --D---------------------------------------------------------
DDB0229972_Ddis  YKDPHAVTGLLKLFLRELPESILPEHLRIQSTEILSNGRFGEKEKIKEI-QTLLSNLSRP
DDB0229973_Ddis  ------------------------------------------------------------
DDB0230010_Ddis  ------------------------------------------------------------
IfkA_Ddis        -----------------------------------------KKSKIETLVQTSLSKL---
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    -------------------------------------------------SSSSIG-----
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    ------------------------------------------------------------


NIK_Hsap         -------------------EFHRVKVGDIATGISS--QIPAAAFSLVTKDGQPVRYDMEV
NIK_Mmus         -------------------EFHRVKVGDIATGISS--QIPATAFSLVTKDGQPVCYDMEV
COT_Mmus         ------------------------------------------------------------
COT_Hsap         ------------------------------------------------------------
DDB0229972_Ddis  HYNVLKHMLFFAKLVVDRSEYNKMVIANVTTCFSPTLRIPPGLFNFLIN-----TY----
DDB0229973_Ddis  ------------------------------------------------------------
DDB0230010_Ddis  -------------------------------------------------------K----
IfkA_Ddis        -----------------------------FRGFI--QSKSSTIRVIVTDLAYSVIRDLQI
CC1G_01579_Ccin  ------------------------------------------------------------
AqueK223_Aque    --------------------------------------------------------GLTS
STE-Un_a_Smoe    ------------------------------------------------------------
STE-Un_b_Smoe    -----------------------------------------------------------A


NIK_Hsap         PDSGIDLQCTLAP-----------------DGSFAWSWRV------------KHGQLENR
NIK_Mmus         PDSGIDLQCTLAP-----------------DGSFAWTWRV------------KHGQLENR
COT_Mmus         ------------------------------LGALAGYFNI-----------VRGPPTLEY
COT_Hsap         ------------------------------LGALAGYFNL-----------VRGPPTLEY
DDB0229972_Ddis  --------------------------------------DL------------SFPKFNLS
DDB0229973_Ddis  ----------------------------------------------------LKNTGMMT
DDB0230010_Ddis  ---------------------------------------------------NLLLDNFVA
IfkA_Ddis        SESHDNI--------SKFQRVSKEKLLQ-LKNQ-IFKWKVYPFIVIHSIKDDKSVIFNSV
CC1G_01579_Ccin  ------------------------------ENE-MEAWLA------------RLWDWPQA
AqueK223_Aque    SSAPP----------NFNG----------------GCWED-----------DIEKDGPNN
STE-Un_a_Smoe    ---------------------------------------------------------KLV
STE-Un_b_Smoe    PDTDISMSCVVDAARDKPAESLEPESPKVAKKS-LVSWLC--------------CGCWNR


NIK_Hsap         P
NIK_Mmus         P
COT_Mmus         G
COT_Hsap         G
DDB0229972_Ddis  V
DDB0229973_Ddis  E
DDB0230010_Ddis  F
IfkA_Ddis        V
CC1G_01579_Ccin  S
AqueK223_Aque    S
STE-Un_a_Smoe    E
STE-Un_b_Smoe    P