RHOK_Hsap MD-FGSLETVVANSAFIAARGSFDGSSSQPSRDKKYLAKLKLPPLSKCESLRDSLSLEFE
GPRK7_Hsap MVDMGALDNLIANTAYLQARKPSDCDS---KELQRRRRSLALPGLQGCAELRQKLSLNFH
GPRK6_Hsap M----ELENIVANTVLLKAREGGGG--NRKGKSKKWRQMLQFPHISQCEELRLSLERDYH
GPRK5_Hsap M----ELENIVANTVLLKAREGGGG--KRKGKSKKWKEILKFPHISQCEDLRRTIDRDYC
GPRK4_Hsap M----ELENIVANSLLLKARQGGYG--KKSGRSKKWKEILTLPPVSQCSELRHSIEKDYS
Gprk2_Dmel M----ELENIVANTVYLKAREGGSD--SNKGKSKKWRKILQFPHISQCINLKDKLDISYG
GPRK6_Mmus M----ELENIVANTVLLKAREGGGG--NRKGKSKKWRQMLQFPHISQCEELRLSLERDYH
GPRK5_Mmus M----ELENIVANTVLLKAREGGGG--KRKGKSKKWKEILKFPHISQCEDLRRTIDRDYY
GPRK4_Mmus M----ELENFVANNLLLKARLGF-N--KQTGRSKKWRELLKFPPVSMCTELRWSIEKDFS
F19C6.1_Cele M----EIENIVANTVYIKARESG-G--QKKGKSKKWKNYLQFPHYTECLPLKTEIEVTYA
RHOK_Mmus MD-FGSLETVVANSAFIAARGSFDGSSTPSSRDKKYLAKLRLPPLSKCEGLRDNLSLEFE
GPRK_Spur ------------------------------------------------------------
AqueK008_Aque --------------------------------------MLKLPPVGTCLPLRDKIDHTFE
RHOK_Hsap SVCLEQPIGKKLFQQFLQS-AEKHLPALELWKDIEDYDTADNDLQPQK--AQ-TILAQYL
GPRK7_Hsap SLCEQQPIGRRLFRDFLAT-VPTFRKAATFLEDVQNWELAEEGPTKDS--ALQGLVATCA
GPRK6_Hsap SLCERQPIGRLLFREFCAT-RPELSRCVAFLDGVAEYEVTPDDKRKAC--GR-QLTQNFL
GPRK5_Hsap SLCDKQPIGRLLFRQFCET-RPGLECYIQFLDSVAEYEVTPDEKLGEK--GK-EIMTKYL
GPRK4_Hsap SLCDKQPIGRRLFRQFCDT-KPTLKRHIEFLDAVAEYEVADDEDRSDC--GL-SILDRFF
Gprk2_Dmel YVIDQQPIGRELFRLFCENKRPVYFRYITFLDEVVKYEIEYISNRIFI--GH-DIGRRFL
GPRK6_Mmus SLCERQPIGRLLFREFCAT-RPELTRCTAFLDGVSEYEVTPDEKRKAC--GR-RLMQNFL
GPRK5_Mmus SLCDKQPIGRLLFRQFCET-RPGLECYIQFLDLVAEYEITPDENLGAK--GK-EIMTKYL
GPRK4_Mmus SLCDKQPIGRLLFRQFCDT-KPDLKRCIEFLDAVAEYEVTIEEEQREF--GL-AIFSRFF
F19C6.1_Cele FVVEKQPIGKLLFHEFCQATNSQYHQCCQFLTKVEEYETSDDDGQSRRDLAS-SIVSLL-
RHOK_Mmus SLCSEQPIGKRLFQQFLKT-DERHVPALELWKDIEDYDTADDDLRPQK--AQ-AILAEYL
GPRK_Spur ------------------------------------------------------------
AqueK008_Aque FIVEQQPIGHKLFLLFCEK-DLKLSRCMQFLHAVDELKIVVEGKRLAH--AQ-TVFDDFL
RHOK_Hsap DPQ-AK------------------------------------------------------
GPRK7_Hsap SAPAPG------------------------------------------------------
GPRK6_Hsap SHT-GP------------------------------------------------------
GPRK5_Hsap TPK-SP------------------------------------------------------
GPRK4_Hsap NDK-LA------------------------------------------------------
Gprk2_Dmel DVE-AQLELRNGSGGDALDAETQEELLLNSSNANPTETAETEHCNNTTANNCNNINNSNN
GPRK6_Mmus SHT-GP------------------------------------------------------
GPRK5_Mmus TPK-SP------------------------------------------------------
GPRK4_Mmus KEK-SE------------------------------------------------------
F19C6.1_Cele -HS-KPED-------------------------NPSGSQ---------------------
RHOK_Mmus DPQ-GT------------------------------------------------------
GPRK_Spur ------------------------------------------------------------
AqueK008_Aque SLD-SPQD-------------------------QASKF----------------------
RHOK_Hsap ------------------------------------------------------------
GPRK7_Hsap ------------------------------------------------------------
GPRK6_Hsap ------------------------------------------------------------
GPRK5_Hsap ------------------------------------------------------------
GPRK4_Hsap ------------------------------------------------------------
Gprk2_Dmel SQHSSDINHKKLDTRNHNGDDATGNGSSHQDDGDESVKCQEGHDDAEKGGGGEGGGGGKC
GPRK6_Mmus ------------------------------------------------------------
GPRK5_Mmus ------------------------------------------------------------
GPRK4_Mmus ------------------------------------------------------------
F19C6.1_Cele ------------------------------------------------------------
RHOK_Mmus ------------------------------------------------------------
GPRK_Spur ------------------------------------------------------------
AqueK008_Aque ------------------------------------------------------------
RHOK_Hsap ---------LFCSFLDEGIVAKFK----E-GPVE--IQDGLFQPLLQATLAHLGQAPFQE
GPRK7_Hsap ---------NPQPFLSQAVATKCQ----A-ATTEE-ERVAAVTLAKAEAMAFLQEQPFKD
GPRK6_Hsap ---------DLIPEVPRQLVTNCT----Q-RLEQ-GPCKDLFQELTRLTHEYLSVAPFAD
GPRK5_Hsap ---------VFIAQVGQDLVSQTE----E-KLLQ-KPCKELFSACAQSVHEYLRGEPFHE
GPRK4_Hsap ---------APLPEIPPDVVTECR----L-GLKEENPSKKAFEECTRVAHNYLRGEPFEE
Gprk2_Dmel VPVGGYPDELVLDVLNDDLIAQVR----N-KLN--SGGKDIFAQCVNAVKAFLAGEPFRE
GPRK6_Mmus ---------DLIPEVPRQLVSNCA----Q-RLEQ-GPCKDLFQELTRLTHEYLSTAPFAD
GPRK5_Mmus ---------VFIAQVGQDLVSQTE----K-KLLQ-SPCKELFSACAQSVHDYLKGDPFHE
GPRK4_Mmus ---------VPLPEIPPDIVKECK----W-NLKQNSPSQNVFEECAGIVCKYLSETPFEE
F19C6.1_Cele -----DEQEFWCSFLSDEVISTCITTADSATHD-DEPRSDIFTEPYRLTCQYLTDAPFKE
RHOK_Mmus ---------LFCNFLDQGMVTRVK----E-GPTG--SQDGLFQPLLQATMEHLSQAPFQE
GPRK_Spur ------------------------------------------------------------
AqueK008_Aque ------LGAGKLECVSDELATKTQ----E-KLKG-IVPVDVFEECRQAVRDFLSGQPLID
RHOK_Hsap YLGSLYFLRFLQWKWLEAQPMGEDWFLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKK
GPRK7_Hsap FVTSAFYDKFLQWKLFEMQPVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKK
GPRK6_Hsap YLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKK
GPRK5_Hsap YLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKK
GPRK4_Hsap YQESSYFSQFLQWKWLERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKK
Gprk2_Dmel FESSMYFHRYLQWKWLEAQPITYKTFRMYRVLGKGGFGEVCACQVRATGKMYACKKLEKK
GPRK6_Mmus YLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKK
GPRK5_Mmus YLDSMYFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKK
GPRK4_Mmus YQESTYFNRFLQWKWLERRPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKK
F19C6.1_Cele FAESMYFHRFLQWKWLEKRPVDKHTFRLYRVLGKGGFGEVCACQVRASGKMYALKKLEKK
RHOK_Mmus YLESLYFLRFLQWKWLEAQPIGEDWFLDFRVLGKGGFGEVSACQMKATGKMYACKKLNKK
GPRK_Spur ------------------------------------------------------------
AqueK008_Aque FVESPFYWRFLQWKTLERMIITKDHFRQYRVLGKGGFGLVFACQSKFTGKMYALKKLEKK
RHOK_Hsap RLKKRKGYQGAMVEKKILMKVHSRFIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNE
GPRK7_Hsap RLKKKGGEKMALLEKEILEKVSSPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVG-
GPRK6_Hsap RIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMG-
GPRK5_Hsap RIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMG-
GPRK4_Hsap RIKKRKGEAMALNEKRILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLG-
Gprk2_Dmel RIKKRKGESMVLIEKQILQKINSPFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMG-
GPRK6_Mmus RIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMG-
GPRK5_Mmus RIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMG-
GPRK4_Mmus RIKKRKGEAMALNEKRILEKLHSRFVVSLAYTYETKDALCLVLTIMNGGDLKYHIYNLG-
F19C6.1_Cele RVKKRHAETLSLNEKQILQRINSPFVVSLAYAYETKDALCLVLTLMNGGDLKFHLYNLM-
RHOK_Mmus RLKKRKGYQGAIVEKRILTKVHSRFIVSLAYAFETKTDLCLVMTIMNGGDVRYHIYNVDE
GPRK_Spur --------------------------VSLAYAFEMKEALCLVLTIMNGGDLKFHIHNMG-
AqueK008_Aque RVKKRKGEKLALNEKEVLEKVDSRFVVTLAYAYQSKDSLCMVLTLMNGGDLRFHIYSIG-
*.***::: * **:*:::*****:::*:: :
RHOK_Hsap ENPGFPEPRALFYTAQIICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLD
GPRK7_Hsap -TRGLDMSRVIFYSAQIACGMLHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKG
GPRK6_Hsap -QAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPE
GPRK5_Hsap -NPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPE
GPRK4_Hsap -NPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPE
Gprk2_Dmel GEPGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVRISDLGLAVEIPE
GPRK6_Mmus -QAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPE
GPRK5_Mmus -NPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPE
GPRK4_Mmus -DPGFEEPRAVFYAAELCCGLEDLQRKRIVYRDLKPENILLDDHGHIRISDLGLAMEVPE
F19C6.1_Cele -PGGFDEKRVQFYAAEITLGLQHLHSERILYRDLKPENILLDDFGHVRISDLGLAVEIKD
RHOK_Mmus DNPGFSEPRAIYYTAQIISGLEHLHQRRIVYRDLKPENVLLDNDGNIRISDLGLAVELKE
GPRK_Spur -SPGFEEERARFYAAEILCGLEDLHRLRIVYRDMKPENILLDDHGHVRISDLGLAVEIPE
AqueK008_Aque -SPGLEPERVVFYAAEIACGLHHLHTARIAYRDMKPDNILLDDAGHIRISDLGLAVHIPE
*: *. :*:*:: *: .*: *** **:*:***: *: *:****** .:
RHOK_Hsap GQSKTKGYAGTPGFMAPELLQ-GEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKE
GPRK7_Hsap GKP-ITQRAGTNGYMAPEILMEKVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKED
GPRK6_Hsap GQT-IKGRVGTVGYMAPEVVK-NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREE
GPRK5_Hsap GDL-IRGRVGTVGYMAPEVLN-NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREE
GPRK4_Hsap GQR-VRGRVGTVGYMAPEVVN-NEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEE
Gprk2_Dmel GEM-VRGRVGTVGYMAPEVID-NEKYAFSPDWFSFGCLLYEMIEGQAPFRMRKEKVKREE
GPRK6_Mmus GQT-IKGRVGTVGYMAPEVVR-NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREE
GPRK5_Mmus GDL-IRGRVGTVGYMAPEVLN-NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREE
GPRK4_Mmus GEM-VRGRVGTVGYMAPEIIN-HEKYTFSPDWWGLGCLIYEMIAGHSPFRKYKEKVNREE
F19C6.1_Cele NEP-IKGRVGTVGYMAPEIVK-NERYSYGVDWWGVGCLIYEMIEGKAPFRQRKEKVKREE
RHOK_Mmus GQNKTKGYAGTPGFMAPELLR-GEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKE
GPRK_Spur NDT-IRGRVGTVGYMAPEVVK-NERYTFSPDYWGLGCLIYEMIEGRAPFRARKEKVKREE
AqueK008_Aque GQS-VRGRVGTPGYMAPEVID-GHRYTFAPDWWGMGCLIYEMICGRTPFRKHKERVSRED
.. .** *:****:: * *::..* :***: .: **: :::. ::
RHOK_Hsap LKHRIISEPVKY-PDKFSQASKDFCEALLEKDPEKRLGFRD-----ETCDKLRAHPLFKD
GPRK7_Hsap LKQRTLQDEVKFQHDNFTEEAKDICRLFLAKKPEQRLGSRE-----K-SDDPRKHHFFKT
GPRK6_Hsap VERLVKEVPEEY-SERFSPQARSLCSQLLCKDPAERLGCRG-----GSAREVKEHPLFKK
GPRK5_Hsap VDRRVLETEEVY-SHKFSEEAKSICKMLLTKDAKQRLGCQE-----EGAAEVKRHPFFRN
GPRK4_Hsap VDQRIKNDTEEY-SEKFSEDAKSICRMLLTKNPSKRLGCRG-----EGAAGVKQHPVFKD
Gprk2_Dmel VDRRVKEDPEKY-SSKFNDEAKSMCQQLLAKSIKQRLGCRNG---RMGGQDVMAHPFFHS
GPRK6_Mmus VERLVKEVAEEY-TDRFSSQARSLCSQLLSKDPAERLGCRG-----GGAREVKEHPLFKK
GPRK5_Mmus VDRRVLETEEVY-SSKFSEEAKSICNMLLTKDSKQRLGCQE-----EGAAEVKRHPFFRN
GPRK4_Mmus LERRVKNETEEY-SERFSEDAKSICSMLLIKDPSKRLGCQR-----DGVSAVKQHPIFKD
F19C6.1_Cele VERRVREDQEKY-SEKFSEAARTLCRGLLHKEPGFRLGCRRVGRPEDGAEEIRAHPFFNT
RHOK_Mmus LKQRIISEPVKY-PEKFSQASKDFCEQLLEKDPEKRLGFRD-----GTCDALRANVLFKD
GPRK_Spur VDRRVKEDDEKY-SQKFSTEAQDICKKLLQKDPALRMGFEN-----GTAQTVKDHSFFNS
AqueK008_Aque IERRIKDDRVCLDNSAFTEDSRSICDQFLDKVHATRLGCCG-----EMFEDVKAHPFFQT
:.: . *. :: :* :* * *:* : .*.
RHOK_Hsap ---------LNWRQLEAGMLMPPFIPDSKTVYAKDIQDVGAFSTVKGVAFDKTDTEFFQE
GPRK7_Hsap ---------INFPRLEAGLIEPPFVPDPSVVYAKDIAEIDDFSEVRGVEFDDKDKQFFKN
GPRK6_Hsap ---------LNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGVELEPTDQDFYQK
GPRK5_Hsap ---------MNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSK
GPRK4_Hsap ---------INFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSVVKGIYLDTADEDFYAR
Gprk2_Dmel T-------QLNWRRLEAGMLEPPFVPDPHAVYAKDVLDIEQFSTVKGVNIDESDTNFYTK
GPRK6_Mmus ---------LNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGVDLEPTDQDFYQK
GPRK5_Mmus ---------MNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSK
GPRK4_Mmus ---------INFSRLEANMLDPPFIPDPQAIYCRNILDIGQFSVVKGVNLDTNDEIFYAE
F19C6.1_Cele ADTVTGREPVPWKKMEAGKVTPPFCPDPRAVYAKDVLDIEQFSTVKGVRLDATDTQFYGK
RHOK_Mmus ---------ISWRQLEAGMLIPPFIPDSRTVYAKNIQDVGAFSTVKGVVFDKADTEFFQE
GPRK_Spur ---------ISFSRLEAGKLDPPFEPDKRAVYAKDVLDIEQFSTVKGVNLDQNDDRFYTK
AqueK008_Aque ---------IDFAHLEAGLIPPPFIPNSRAVYAKDVLDIDQFSSVRGVEIEKADEDFADK
: : :: *. : *** *: .:*.::: :: ** *:*: :: * * .
RHOK_Hsap FATGNCPIPWQEEMIETGIFGELNVWRS-DGQMPDDMKG-----ISG-------------
GPRK7_Hsap FATGAVPIAWQEEIIETGLFEELNDPNR----------P-----TGC-------------
GPRK6_Hsap FATGSVPIPWQNEMVETECFQELNVFGL-DGSVPPDLDW----KG-QPPAPPKKGLLQRL
GPRK5_Hsap FSTGSVSIPWQNEMIETECFKELNVFGP-NGTLPPDLNR-----N-HPPEPPKKGLLQRL
GPRK4_Hsap FATGCVSIPWQNEMIESGCFKDINKSES-EEALPLDLDK----NIHTPVSRPNRGFFYRL
Gprk2_Dmel FNTGSVSISWQNEMMETECFRELNVFGP-EECPTPDLQI------NAAPEPDKAGCFP--
GPRK6_Mmus FATGSVSIPWQNEMVETECFQELNVFGL-DGSVPPDLDW----KG-QPTAPPKKGLLQRL
GPRK5_Mmus FSTGSVPIPWQNEMIETECFKELNVFGP-NGTLSPDLNR-----S-QPPEPPKKGLFHRL
GPRK4_Mmus FATGSVTIPWQNEMIESGCFKDLNENED-DLSSLEKYK-----MC-SSILRPKRNFFRRL
F19C6.1_Cele FNTGCVSIPWQSEMIETECFAELNTFHDEDGNVMWNLRPDGINMDERRNGTSKPGFFSRL
RHOK_Mmus FASGNCSIPWQEEMIETGLFGDLNVWRA-DGQMPDDMKG-----ITT-------------
GPRK_Spur FNSGSVAIPWQMEMIETQVFLELNVFGP-NGTLTADLMP------DLPPPPPKQGFFRRI
AqueK008_Aque FATGIVPKPWQEEVSS--------------------------------------------
* :* . .** *: .
RHOK_Hsap --------G-----------------------------SSSSSKSGMCLVS
GPRK7_Hsap --------E-----------------------------EGNSSKSGVCLLL
GPRK6_Hsap FSRQRIAVETA------------ATARKSS--PP---ASSPQPEAPTSSWR
GPRK5_Hsap FKRQHQNNSKS------------SPSSKTS--FN-HHINSNHVSSNSTGSS
GPRK4_Hsap FRRGGCLTM--------------VPSE----------------KEVEPKQC
Gprk2_Dmel FRRKKKQPART------------QPI----PIPE-HLLTTSHSVSSTTVES
GPRK6_Mmus FSRQRIAVGTA------------ATVRKSS--PP---ASSPQAEAPTGGWR
GPRK5_Mmus FRRQHQSNSKS------------SPTPKTS--CN-HRINSNHINSNSTGSS
GPRK4_Mmus FRRTGCLNI--------------AL-S----------------EEREPTEH
F19C6.1_Cele FRKKNIEVTKSLHDLSHLGVEQQQPPKTSTQTPA-VRSSRAASASGRTLVI
RHOK_Mmus --------EE----------------------------AAPTAKSGMCLIS
GPRK_Spur FRIKDIKEKDG-----------KNKSTKGLQSEKIFEYRKSKEIYGVHNTP
AqueK008_Aque --------------------------------------------------T