Kinase Family NEK
From WikiKinome
Kinase Classification: Group Other: Family NEK
Nek is a large family of kinases with multiple conserved subfamilies. Neks are widespread throughout eukaryotes, with several subfamilies emerging in fungi or metazoa.
Subfamilies
NEK1
Includes Human NEK1, NEK3, and NEK5. Found in most eukaryotes, but lost in fungi, Drosophila and C. elegans.
NEK2
Found in fungi, animals and Dictyostelium. All have an N-terminal kinase domain and C-terminal extension. Includes the Aspergillus nimA after which the family is named.
NEK4
NEK6
Animal-specific NEK with roles in mitosis, cytokines and endocytosis. Regulated by NEK9.
NEK8
NEK9
NEK10
Animal specific NEK with roles in DNA damage response and cilium biology.
