Kinase Family Wee

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Kinase Classification: Group Other: Family WEE

Wee kinase was discovered in S. pombe (1). For a perspective on its discovery see (2). There are two WEE family kinases in the Schizosaccharomyces, wee1 and mik1 (3), both of which inhibit entry into mitosis by phosphorylating Cdc2 on Tyr15. Wee1 inhibits entry into mitosis based on cell-size, while Mik1 inhibits entry into mitosis based on replicative stress (4). Budding yeast appears to have lost the mik1 ortholog (JMG, 3/8/11).

The Wee family has the following subfamilies:

Subfamily WEE1

Subfamily Myt1



1: Nurse P, Thuriaux P. Regulatory genes controlling mitosis in the fission yeast Schizosaccharomyces pombe. Genetics. 1980 Nov;96(3):627-37. PubMed PMID: 7262540; PubMed Central PMCID: PMC1214365.

2: Nurse P. Wee beasties. Nature. 2004 Dec 2;432(7017):557. PubMed PMID: 15577889. (MUST READ!)

3: Lundgren K, Walworth N, Booher R, Dembski M, Kirschner M, Beach D. mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2. Cell. 1991 Mar 22;64(6):1111-22. PubMed PMID: 1706223.

4: Rhind N, Russell P. Roles of the mitotic inhibitors Wee1 and Mik1 in the G(2) DNA damage and replication checkpoints. Mol Cell Biol. 2001 Mar;21(5):1499-508. PubMed PMID: 11238887; PubMed Central PMCID: PMC86696.